Title:
STEM CELL-DERIVED MATURE CARDIOMYOCYTES AND CARDIOVASCULAR DISEASE MODEL USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/071011
Kind Code:
A1
Abstract:
The present invention relates to stem cell-derived mature cardiomyocytes and a cardiovascular disease model using same and, more specifically, to differentiation into mature ventricular cardiomyocytes by culturing stem cells in a medium containing FGF4 and ascorbic acid, and use of the differentiated mature ventricular cardiomyocytes as a cardiovascular disease cell model. The mature ventricular cardiomyocytes, obtained by culturing stem cells in a medium containing FGF4 and ascorbic acid and inducing the differentiation thereof, and cardiovascular disease cell model using same according to the present invention are very useful for screening for cardiovascular disease therapeutic agents and evaluation of the toxicity of new drugs.
Inventors:
LIM DO-SUN (KR)
CHOI SEUNG CHEOL (KR)
JOO HYUNG JOON (KR)
KIM JONG-HO (KR)
PARK CHI-YEON (KR)
PARK YONGDOO (KR)
CHOI SEUNG CHEOL (KR)
JOO HYUNG JOON (KR)
KIM JONG-HO (KR)
PARK CHI-YEON (KR)
PARK YONGDOO (KR)
Application Number:
PCT/KR2019/015386
Publication Date:
April 15, 2021
Filing Date:
November 13, 2019
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12N5/077; G01N33/50
Domestic Patent References:
| WO2005042703A2 | 2005-05-12 | |||
| WO2012012803A2 | 2012-01-26 |
Foreign References:
| KR20170020273A | 2017-02-22 | |||
| KR101771474B1 | 2017-08-25 | |||
| US20090028830A1 | 2009-01-29 |
Attorney, Agent or Firm:
CHANG, Je Hwan et al. (KR)
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