STEM CELL PRIMING COMPOSITION AND PRIMED STEM CELL

Title:

STEM CELL PRIMING COMPOSITION AND PRIMED STEM CELL

Document Type and Number:

WIPO Patent Application WO/2022/139399

Kind Code:

A1

Abstract:

The present invention relates to a composition, comprising: TNF-α, IFN-γ, and IFN-α; or TNF-α, IFN-γ, IFN-α, and a vitamin, for promoting immunomodulatory activity and inflammation-modulating ability of stem cells, and a method for preparing stem cells having improved immunomodulatory activity and inflammation-modulating ability by using same. Treatment of stem cells with: TNF-α, IFN-γ, and IFN-α; or TNF-α, IFN-γ, IFN-α, and a vitamin according to the present invention leads to upregulation of the expression of factors associated with the immunoregulatory activity and anti-inflammatory effects of stem cells and thus enables the preparation of functionally reinforced stem cells. The functionally reinforced stem cells thus prepared can find a wide spectrum of applications in various immune, inflammatory disease therapy fields.

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Inventors:

SONG SUN UK (KR)
KIM SI NA (KR)

Application Number:

PCT/KR2021/019485

Publication Date:

June 30, 2022

Filing Date:

December 21, 2021

Export Citation:

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Assignee:

SCM LIFESCIENCE CO LTD (KR)

International Classes:

C12N5/0775; A61K35/28

Foreign References:

KR101865040B1	2018-06-11
KR20190128315A	2019-11-18
KR20110095550A	2011-08-25

Other References:

SALEIRO DIANA, RADECKI SARA G., PLATANIAS LEONIDAS C.: "Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy", TRANSLATIONAL CANCER RESEARCH, vol. 5, no. S6, 1 November 2016 (2016-11-01), pages S1039 - S1043, XP055827696, ISSN: 2218-676X, DOI: 10.21037/tcr.2016.11.12
DE WITTE SAMANTHA F. H., MERINO ANA M., FRANQUESA MARCELLA, STRINI TANJA, VAN ZOGGEL JOHANNA A. A., KOREVAAR SANDER S., LUK FRANKA: "Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease", STEM CELL RESEARCH & THERAPY, vol. 8, no. 1, 1 December 2017 (2017-12-01), XP055827694, DOI: 10.1186/s13287-017-0590-6

Attorney, Agent or Firm:

KIM, Soon Woong (KR)

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