Title:
STEMNESS-SUPPRESSING COMPOSITION COMPRISING OCT4 FUNCTION-INHIBITING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2019/190066
Kind Code:
A1
Abstract:
The present invention relates to a stemness-supressing composition comprising an OCT4 function-inhibiting peptide and, more particularly, to a composition comprising a peptide as an effective ingredient for suppressing the stemness of various stem cells such as general stem cells, cancer stem cells, and the like, wherein the peptide inhibits the function of OCT4 by inducing the phosphorylation of OCT4. OCT4 function-inhibiting peptides of the present invention are expected to find applications in various fields through the suppressive activity thereof against stemness of stem cells.
Inventors:
JANG HYONCHOL (KR)
LEE BYUNG IL (KR)
YOUN HONG-DUK (KR)
SONG BOMIN (KR)
LEE BYUNG IL (KR)
YOUN HONG-DUK (KR)
SONG BOMIN (KR)
Application Number:
PCT/KR2019/002527
Publication Date:
October 03, 2019
Filing Date:
March 05, 2019
Export Citation:
Assignee:
NAT CANCER CT (KR)
International Classes:
A61K38/16; A61K38/08; A61K38/10; A61P35/00; G01N33/50; G01N33/574
Domestic Patent References:
| WO2009061837A1 | 2009-05-14 |
Other References:
SHIN, JIHOON ET AL.: "Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells", ELIFE, vol. 5, 2016, pages 1 - 21, XP055548776
LIN, YUANJI ET AL.: "Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells", MOLECULAR CELL, vol. 48, no. 4, 2012, pages 627 - 640, XP055638843
SHIN, JIHOON ET AL.: "Oct4 resetting by Aurkb-PP1 cell cycle axis determines the identity of mouse embryonic stem cells", BMB REPORTS, vol. 49, no. 10, 2016, pages 527 - 528, XP055638844
MALAK, PETER N ET AL.: "Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4", CELL CYCLE, vol. 14, no. 23, 2015, pages 3748 - 3754, XP055638845
LIN, YUANJI ET AL.: "Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells", MOLECULAR CELL, vol. 48, no. 4, 2012, pages 627 - 640, XP055638843
SHIN, JIHOON ET AL.: "Oct4 resetting by Aurkb-PP1 cell cycle axis determines the identity of mouse embryonic stem cells", BMB REPORTS, vol. 49, no. 10, 2016, pages 527 - 528, XP055638844
MALAK, PETER N ET AL.: "Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4", CELL CYCLE, vol. 14, no. 23, 2015, pages 3748 - 3754, XP055638845
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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