Title:
STEROID COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/131310
Kind Code:
A1
Abstract:
Disclosed in the present invention are a steroid compound, and a preparation method therefor and the use thereof. The structure of the steroid compound is as shown in formula I, and the definition of each substituent in the formula are as described in the description and claims. The steroid compound of the present invention is a steroid compound having the dual functions of excellent AR antagonistic activity and AR degradative activity, has the characteristics of good druggability and safety, and can be used for treating diseases related to an AR signaling pathway.
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Inventors:
YANG YUSHE (CN)
WANG AO (CN)
LUO XIANGGANG (CN)
WANG YAWAN (CN)
WANG AO (CN)
LUO XIANGGANG (CN)
WANG YAWAN (CN)
Application Number:
PCT/CN2023/071074
Publication Date:
July 13, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/56; C07J43/00; A61P5/26
Domestic Patent References:
| WO2012083112A2 | 2012-06-21 | |||
| WO2014153215A1 | 2014-09-25 | |||
| WO2010091299A2 | 2010-08-12 | |||
| WO2013096907A1 | 2013-06-27 | |||
| WO2019160889A1 | 2019-08-22 |
Foreign References:
| CN107365343A | 2017-11-21 | |||
| CN108707177A | 2018-10-26 |
Other References:
VINCENT C. O. NJAR, ANGELA M. H. BRODIE: "Discovery and Development of Galeterone (TOK-001 or VN/124-1) for the Treatment of All Stages of Prostate Cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 5, 12 March 2015 (2015-03-12), US , pages 2077 - 2087, XP055346419, ISSN: 0022-2623, DOI: 10.1021/jm501239f
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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