Title:
STEROID SULFAMATES, METHOD FOR THE PRODUCTION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO1998042729
Kind Code:
A3
Abstract:
Gonadal and D-homo gonadal steroid derivatives of formula (I) and their salts are new. A double bond may be present between atoms 9 and 11, 8 and 9, 8 and 14, 14 and 15, 6 and 7 or 7 and 8; between atoms 8 and 9 and 14 and 15 or between 8 and 9 and 7 and 6, two double bonds may be present; or a cyclopropane or epoxide group with alpha or beta orientation may be present between atoms 14 and 15; atoms 2, 3, 4, 6, 7, 11, 12, 15, 16 and/or 17 are optionally substituted by 1-6C alkoxy, (1-4C alkoxy)(1-4C alkoxy), hydroxy(1-4C alkoxy), 1-6C alkanoyloxy or tris(1-4C alkyl)silyloxy or OH and in the case of the presence of a second OH group, a group such as ketal, thioketal, cyanohydrin, cyanosilylether or geminal hydroxyethynyl group may be present as a protecting group; n = 1 or 2; R1 = H, alpha - or beta -Me or beta -Et; R3 = H, halo (e.g. Cl, Br, I, At, F, 18F, and preferably additional residues R4 and/or R5 are present on atoms 1, 2, 3, 4, 6, 7, 11, 15, 16 and/or 17; R4 = aryl or 1-12C alkyl; R2 = H, 1-5C alkyl, 1-3C alkyl with an annelatted saturated ring, or aryl(1-3C alkyl); R6 = halo (e.g. Cl, Br, 76Br, F, 18F or At); and m = 1-5 (preferably 1-3); with the proviso that R3 is not H when m = 1 and the sulphamoyloxy group is attached to the aromatic A-ring.
More Like This:
Inventors:
KASCH HELMUT (DE)
SCHUMANN WINFRIED (DE)
ROEMER JOHANNES (DE)
STEINBACH JOERG (DE)
SCHUMANN WINFRIED (DE)
ROEMER JOHANNES (DE)
STEINBACH JOERG (DE)
Application Number:
PCT/DE1998/000813
Publication Date:
January 14, 1999
Filing Date:
March 18, 1998
Export Citation:
Assignee:
KNOELL HANS FORSCHUNG EV (DE)
ROSSENDORF FORSCHZENT (DE)
KASCH HELMUT (DE)
SCHUMANN WINFRIED (DE)
ROEMER JOHANNES (DE)
STEINBACH JOERG (DE)
ROSSENDORF FORSCHZENT (DE)
KASCH HELMUT (DE)
SCHUMANN WINFRIED (DE)
ROEMER JOHANNES (DE)
STEINBACH JOERG (DE)
International Classes:
A61K31/565; A61K51/00; A61P5/30; A61P15/12; A61P35/00; A61P43/00; C07J41/00; C07J53/00; C07J63/00; C07J71/00; (IPC1-7): C07J/
Domestic Patent References:
WO1996005216A1 | 1996-02-22 |
Foreign References:
US3951958A | 1976-04-20 | |||
US3951959A | 1976-04-20 | |||
DE2426777A1 | 1975-12-18 |
Other References:
See also references of EP 0970104A2
Download PDF: