Title:
STEROID SYNTHETASE INHIBITORS AND THERAPEUTIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/057142
Kind Code:
A1
Abstract:
Steroid synthetase inhibitors and the therapeutic use thereof, which belong to the field of medicines. The compounds for use as drugs have the effect of inhibiting steroid synthetases with a high inhibition rate, and can be used as drugs for treating steroid related diseases.
Inventors:
HU QINGZHONG (CN)
YIN LINA (CN)
LI HAIYAN (CN)
GUAN TING (CN)
ZHU HAICHAO (CN)
YIN LINA (CN)
LI HAIYAN (CN)
GUAN TING (CN)
ZHU HAICHAO (CN)
Application Number:
PCT/CN2020/140117
Publication Date:
March 24, 2022
Filing Date:
December 28, 2020
Export Citation:
Assignee:
GUANGZHOU UNIV OF CHINESE MEDICINE GUANGZHOU ACAD OF CHINESE MEDICINE (CN)
International Classes:
A61K31/553; C07D413/04; A61K45/06; A61P3/10; A61P9/00; A61P13/12
Foreign References:
| CN112079826A | 2020-12-15 | |||
| CN109476663A | 2019-03-15 | |||
| CN103958478A | 2014-07-30 | |||
| CN1585752A | 2005-02-23 |
Other References:
ZHU HAICHAO; LIU MEIHUA; LI HAIYAN; GUAN TING; ZHANG QI; CHEN YANG; LIU YINGXIANG; HARTMANN ROLF R.; YIN LINA; HU QINGZHONG: "Design, synthesis and biological evaluation of pyridyl substituted benzoxazepinones as potent and selective inhibitors of aldosterone synthase", CHINESE CHEMICAL LETTERS, vol. 32, no. 7, 10 November 2020 (2020-11-10), AMSTERDAM, NL , pages 2327 - 2332, XP086663229, ISSN: 1001-8417, DOI: 10.1016/j.cclet.2020.11.021
SUDHIR K SINGH , ALEXANDER L RUCHELMAN , TSAI-KUN LI , ANGELA LIU , LEROY F LIU , EDMOND J LAVOIE: "Nitro and amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 11, 1 January 2003 (2003-01-01), US , pages 2254 - 2257, XP002264963, ISSN: 0022-2623, DOI: 10.1021/jm020498a
KARL-HEINZ WUNSCH , ANNEROSE EHLERS: "Benzokondensierte 7-Ring-Heterocyclen, II. 5-Substituierte 2.3-Dihydro-1.4-benzothiazepine", CHEMISCHE BERICHTE, vol. 102, no. 6, 1 June 1969 (1969-06-01), pages 1869 - 1875, XP055911688, DOI: 10.1002/cber.19691020612
DATABASE Registry 14 December 2017 (2017-12-14), ANONYMOUS: "1H-2-Benzazepin-1-one, 6-bromo-2,3,4,5-tetrahydro-2-(1-methyl-1H-pyrazol-4- yl)- (CA INDEX NAME)", XP055911716, retrieved from STN Database accession no. 2158268-67-6
SUDHIR K SINGH , ALEXANDER L RUCHELMAN , TSAI-KUN LI , ANGELA LIU , LEROY F LIU , EDMOND J LAVOIE: "Nitro and amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 11, 1 January 2003 (2003-01-01), US , pages 2254 - 2257, XP002264963, ISSN: 0022-2623, DOI: 10.1021/jm020498a
KARL-HEINZ WUNSCH , ANNEROSE EHLERS: "Benzokondensierte 7-Ring-Heterocyclen, II. 5-Substituierte 2.3-Dihydro-1.4-benzothiazepine", CHEMISCHE BERICHTE, vol. 102, no. 6, 1 June 1969 (1969-06-01), pages 1869 - 1875, XP055911688, DOI: 10.1002/cber.19691020612
DATABASE Registry 14 December 2017 (2017-12-14), ANONYMOUS: "1H-2-Benzazepin-1-one, 6-bromo-2,3,4,5-tetrahydro-2-(1-methyl-1H-pyrazol-4- yl)- (CA INDEX NAME)", XP055911716, retrieved from STN Database accession no. 2158268-67-6
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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