Title:
STILBENE COMPOUND AND APPLICATION THEREOF IN PREVENTION AND/OR TREATMENT FOR CENTRAL NERVOUS SYSTEM-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/109859
Kind Code:
A1
Abstract:
Provided are a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof. The compound can efficiently penetrate a blood-brain barrier, inhibit an inflammatory response of the central nervous system, can be used for preventing and/or treating central nervous system-related diseases or conditions, inhibit secretion of cytokines, inhibit activation of glial cells, and inhibit glutamic acid concentration in vivo. Provided is a potential drug for preventing and/or treating central nervous system-related diseases.
More Like This:
Inventors:
CHEN MING (CN)
MA ZHILONG (CN)
JIA JIANMIN (CN)
MA ZHILONG (CN)
JIA JIANMIN (CN)
Application Number:
PCT/CN2022/138972
Publication Date:
June 22, 2023
Filing Date:
December 14, 2022
Export Citation:
Assignee:
THEDERMA SHANGHAI CO LTD (CN)
International Classes:
A61K31/05; C07C39/21; A61K31/517; A61K31/58; A61P25/28; C07C37/055
Domestic Patent References:
| WO2016092493A1 | 2016-06-16 |
Foreign References:
| CN108066279A | 2018-05-25 | |||
| CN113473969A | 2021-10-01 | |||
| CN112250546A | 2021-01-22 | |||
| US20210346279A1 | 2021-11-11 |
Other References:
HU, YUQING ET AL.: "Effects of Benvimod on the proliferation of HaCaT cells, the secretion of inflammatory factors and the production of skin barrier factors", CHINESE JOURNAL OF DERMATOLOGY, vol. 53, no. 12, 31 December 2020 (2020-12-31), XP009547222
SUSAN H. SMITH, JAYAWICKREME CHANNA, RICKARD DAVID J., NICODEME EDWIGE, BUI THI, SIMMONS CATHY, COQUERY CHRISTINE M., NEIL JESSICA: "Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 137, no. 10, 31 October 2017 (2017-10-31), NL , pages 2110 - 2119, XP055727670, ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.05.004
SUSAN H. SMITH, JAYAWICKREME CHANNA, RICKARD DAVID J., NICODEME EDWIGE, BUI THI, SIMMONS CATHY, COQUERY CHRISTINE M., NEIL JESSICA: "Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 137, no. 10, 31 October 2017 (2017-10-31), NL , pages 2110 - 2119, XP055727670, ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.05.004
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
Download PDF: