Title:
STILBENE DERIVATIVE AS AHR AGONIST AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217049
Kind Code:
A1
Abstract:
The present invention relates to a stilbene derivative as an AhR activator and use thereof. The compound of the present invention, or a pharmaceutically acceptable salt, a tautomer or a stereoisomer thereof has an excellent AhR activation effect, and can be safely used for treating a disease or a related symptom mediated by activity abnormality of AhR and related pathway targets.
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Inventors:
CHEN LEI (CN)
TIAN CHAO (CN)
ZHANG JILEI (CN)
TAO RUI (CN)
HE HONGYAN (CN)
ZHU LIJUN (CN)
LU YINGYAN (CN)
ZHOU JING (CN)
WU XIAOTAO (CN)
LI ZHAN (CN)
TIAN CHAO (CN)
ZHANG JILEI (CN)
TAO RUI (CN)
HE HONGYAN (CN)
ZHU LIJUN (CN)
LU YINGYAN (CN)
ZHOU JING (CN)
WU XIAOTAO (CN)
LI ZHAN (CN)
Application Number:
PCT/CN2023/092595
Publication Date:
November 16, 2023
Filing Date:
May 06, 2023
Export Citation:
Assignee:
NANJING GRITPHARMACO LTD (CN)
International Classes:
C07C39/23; A61K31/05; A61P17/00; A61P29/00; A61P35/00
Domestic Patent References:
| WO2017218967A2 | 2017-12-21 |
Foreign References:
| US20050059733A1 | 2005-03-17 | |||
| CN1407978A | 2003-04-02 | |||
| CN106588581A | 2017-04-26 |
Other References:
LI, LONG ET AL.: "Discovering New DNA Gyrase Inhibitors Using Machine Learning Approaches", RSC ADVANCES, vol. 5, no. 128, 7 December 2015 (2015-12-07), XP093107152, ISSN: 2046-2069
RAYNE SIERRA, GOSS CHARLES D., FOREST KAYA, FRIESEN KEN J.: "Quantitative structure–activity relationships for estimating the aryl hydrocarbon receptor binding affinities of resveratrol derivatives and the antioxidant activities of hydroxystilbenes", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 19, no. 8, 1 November 2010 (2010-11-01), US , pages 864 - 901, XP093107153, ISSN: 1054-2523, DOI: 10.1007/s00044-009-9236-2
RAYNE SIERRA, GOSS CHARLES D., FOREST KAYA, FRIESEN KEN J.: "Quantitative structure–activity relationships for estimating the aryl hydrocarbon receptor binding affinities of resveratrol derivatives and the antioxidant activities of hydroxystilbenes", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 19, no. 8, 1 November 2010 (2010-11-01), US , pages 864 - 901, XP093107153, ISSN: 1054-2523, DOI: 10.1007/s00044-009-9236-2
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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