Title:
STORAGE LIQUID FOR MAMMALIAN CELLS
Document Type and Number:
WIPO Patent Application WO/2020/189538
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel storage liquid for storing mammalian cells over a long period of time in a non-frozen state. Ascorbic acid and/or niacin are added to an isotonic liquid to give a storage liquid. Then the storage liquid is mixed with platelets and stored under shaking. Thus, deterioration in the functions of the platelets and a decrease in the survival rate thereof can be prevented for at least 10 days. When the aforesaid storage liquid is mixed with mesenchymal stem cells, megakaryocytes or T cells and stored in a non-frozen state, deterioration in the functions of these cells and a decrease in the survival rate thereof can be prevented for at least from several days to several ten days.
Inventors:
TOMIZUKA JUNKO (JP)
SHIGEMORI TOMOHIRO (JP)
WATANABE NATSUKI (JP)
TAKENAWA TAICHI (JP)
SHIRAKAWA CHIKAGE (JP)
NISHIMURA MASUHIRO (JP)
FUJITA YASUTAKA (JP)
SAWAMOTO OSAMU (JP)
SHIGEMORI TOMOHIRO (JP)
WATANABE NATSUKI (JP)
TAKENAWA TAICHI (JP)
SHIRAKAWA CHIKAGE (JP)
NISHIMURA MASUHIRO (JP)
FUJITA YASUTAKA (JP)
SAWAMOTO OSAMU (JP)
Application Number:
PCT/JP2020/011002
Publication Date:
September 24, 2020
Filing Date:
March 13, 2020
Export Citation:
Assignee:
MEGAKARYON CORP (JP)
OTSUKA PHARMA FACTORY INC (JP)
OTSUKA PHARMA FACTORY INC (JP)
International Classes:
C12N5/0775; C12N1/04; C12N5/078; C12N5/0783
Domestic Patent References:
| WO2018097226A1 | 2018-05-31 | |||
| WO2017065280A1 | 2017-04-20 | |||
| WO2014208053A1 | 2014-12-31 | |||
| WO2017077964A1 | 2017-05-11 | |||
| WO2017073656A1 | 2017-05-04 | |||
| WO2014208053A1 | 2014-12-31 |
Foreign References:
| JP2016538859A | 2016-12-15 | |||
| JP2018516955A | 2018-06-28 | |||
| US20160205923A1 | 2016-07-21 | |||
| JP2018515099A | 2018-06-14 | |||
| JP2018034667W | 2018-09-19 | |||
| JP2018153196A | 2018-10-04 | |||
| JP2012115253A | 2012-06-21 |
Other References:
HIGA, YUKIE : "No. 16 Effect of preserved PC on platelet function by addition of water-soluble vitamins, About the effect of vitamin C", JOURNAL OF THE JAPAN SOCIETY OF BLOOD TRANSFUSION, vol. 48, no. 1, 2002, pages 48, XP009530637, ISSN: 0546-1448
GIAMMONA, L. M. ET AL.: "Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes", BRITISH JOURNAL OF HAEMATOLOGY, vol. 135, 2006, pages 554 - 566, XP055135582, DOI: 10.1111/j.1365-2141.2006.06341.x
XU, Y. ET AL.: "Tannic acid attenuated irradiation-induced apoptosis in megakaryocytes", EXPERIMENTAL CELL RESEARCH, vol. 370, 2018, pages 409 - 416, XP085447194, DOI: 10.1016/j.yexcr.2018.07.003
TAKAYAMA, BLOOD, vol. 111, 2008, pages 5298 - 5306
TYLER, BLOOD, vol. 121, 2013, pages 308 - 317
CAMPBELL, CLIN VACCINE IMMUNOL, vol. 16, 2009, pages 1648 - 53
TAKAYAMA ET AL., J. EXP. MED., vol. 13, 2010, pages 2817 - 2830
KOBAYASHI ET AL., CELL, vol. 142, no. 5, 2010, pages 787 - 799
"Japanese Red Cross Society, the package insert of Irradiated Washed Platelets-LR ''NISSEKI", JAPANESE JOURNAL OF TRANSFUSION AND CELL THERAPY, vol. 59, no. 3, 2013, pages 492 - 498
NISHIMURA, XENOTRANSPLANTATION, vol. 26, no. 3, May 2019 (2019-05-01), pages e12501
See also references of EP 3940061A4
GIAMMONA, L. M. ET AL.: "Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes", BRITISH JOURNAL OF HAEMATOLOGY, vol. 135, 2006, pages 554 - 566, XP055135582, DOI: 10.1111/j.1365-2141.2006.06341.x
XU, Y. ET AL.: "Tannic acid attenuated irradiation-induced apoptosis in megakaryocytes", EXPERIMENTAL CELL RESEARCH, vol. 370, 2018, pages 409 - 416, XP085447194, DOI: 10.1016/j.yexcr.2018.07.003
TAKAYAMA, BLOOD, vol. 111, 2008, pages 5298 - 5306
TYLER, BLOOD, vol. 121, 2013, pages 308 - 317
CAMPBELL, CLIN VACCINE IMMUNOL, vol. 16, 2009, pages 1648 - 53
TAKAYAMA ET AL., J. EXP. MED., vol. 13, 2010, pages 2817 - 2830
KOBAYASHI ET AL., CELL, vol. 142, no. 5, 2010, pages 787 - 799
"Japanese Red Cross Society, the package insert of Irradiated Washed Platelets-LR ''NISSEKI", JAPANESE JOURNAL OF TRANSFUSION AND CELL THERAPY, vol. 59, no. 3, 2013, pages 492 - 498
NISHIMURA, XENOTRANSPLANTATION, vol. 26, no. 3, May 2019 (2019-05-01), pages e12501
See also references of EP 3940061A4
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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