Title:
STRAIN HAVING IMPROVED AMINO ACID PRODUCTION CAPABILITIES DUE TO GLSB GENE INACTIVATION, AND PRODUCTION METHOD FOR SAME.
Document Type and Number:
WIPO Patent Application WO/2021/085796
Kind Code:
A1
Abstract:
Provided is a mutant strain having improved aromatic amino acid production capabilities as a result of the inactivation or weakening of the activity of glutaminase which is expressed by glutaminase B (glsB) gene.
Inventors:
SHIN WON JOO (KR)
JO YOUNG IL (KR)
LEE SUN HEE (KR)
KIM HYUN YOUNG (KR)
KIM YONG SOO (KR)
YANG CHEOL MIN (KR)
JO YOUNG IL (KR)
LEE SUN HEE (KR)
KIM HYUN YOUNG (KR)
KIM YONG SOO (KR)
YANG CHEOL MIN (KR)
Application Number:
PCT/KR2020/008407
Publication Date:
May 06, 2021
Filing Date:
June 26, 2020
Export Citation:
Assignee:
DAESANG CORP (KR)
International Classes:
C12N15/70; C12N9/80; C12P13/22
Domestic Patent References:
| WO2017151707A1 | 2017-09-08 |
Foreign References:
| KR101830002B1 | 2018-02-19 | |||
| KR101830002B1 | 2018-02-19 |
Other References:
GREG BROWN, ALEX SINGER, MICHAEL PROUDFOOT, TATIANA SKARINA, YOUNGCHANG KIM, CHANGSOO CHANG, IRINA DEMENTIEVA, EKATERINA KUZNETSOV: "Functional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 47, no. 21, 1 May 2008 (2008-05-01), pages 5724 - 5735, XP055044780, ISSN: 00062960, DOI: 10.1021/bi800097h
DATABASE Nucleotide 11 October 2018 (2018-10-11), ANONYMOUS: "Escherichia coli str. K-12 substr. MG1655, complete genome", XP055786868, retrieved from NCBI Database accession no. NC_000913
PEILONG LU, DAN MA, YULING CHEN, YINGYING GUO, GUO-QIANG CHEN, HAITENG DENG, YIGONG SHI: "L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 23, no. 5, 1 May 2013 (2013-05-01), Singapore, pages 635 - 644, XP055520152, ISSN: 1001-0602, DOI: 10.1038/cr.2013.13
DATSENKO KAWANNER BL., PROC NATL ACAD SCI USA., vol. 97, no. 12, 6 June 2000 (2000-06-06), pages 6640 - 5
"Genbank", Database accession no. AY048744
"GenBank", Database accession no. AY048746
See also references of EP 4053281A4
DATABASE Nucleotide 11 October 2018 (2018-10-11), ANONYMOUS: "Escherichia coli str. K-12 substr. MG1655, complete genome", XP055786868, retrieved from NCBI Database accession no. NC_000913
PEILONG LU, DAN MA, YULING CHEN, YINGYING GUO, GUO-QIANG CHEN, HAITENG DENG, YIGONG SHI: "L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 23, no. 5, 1 May 2013 (2013-05-01), Singapore, pages 635 - 644, XP055520152, ISSN: 1001-0602, DOI: 10.1038/cr.2013.13
DATSENKO KAWANNER BL., PROC NATL ACAD SCI USA., vol. 97, no. 12, 6 June 2000 (2000-06-06), pages 6640 - 5
"Genbank", Database accession no. AY048744
"GenBank", Database accession no. AY048746
See also references of EP 4053281A4
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
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