Title:
STRESS BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2017/170572
Kind Code:
A1
Abstract:
The principal purpose of the present invention is to provide a novel stress biomarker which makes it possible to conveniently and accurately assess a state of stress. In addition, the present invention provides a diagnosis kit containing a reagent capable of detecting said biomarker, and a diagnosis method that uses said biomarker. It is possible to use mitochondrial DNA included in a biological fluid as the stress biomarker.
Inventors:
NISHIDA KOHJI (JP)
KUMANOGOH ATSUSHI (JP)
HASHIDA NORIYASU (JP)
KUMANOGOH ATSUSHI (JP)
HASHIDA NORIYASU (JP)
Application Number:
PCT/JP2017/012690
Publication Date:
October 05, 2017
Filing Date:
March 28, 2017
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
| WO2014038622A1 | 2014-03-13 |
Other References:
CAI N. ET AL.: "Molecular Signatures of Major Depression", CURRENT BIOLOGY, vol. 25, 2015, pages 1146 - 1156, XP029219682
CHAN S. W. ET AL.: "Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress", BIOMED RESEARCH INTERNATIONA L, vol. 2013, 2013, XP055427906
LINDQVIST D. ET AL.: "Increased plasma levels of circulating cell -free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity", TRANSL PSYCHIATRY, vol. 6, no. 12, 6 December 2016 (2016-12-06), pages 971, XP055550440
See also references of EP 3438281A4
CHAN S. W. ET AL.: "Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress", BIOMED RESEARCH INTERNATIONA L, vol. 2013, 2013, XP055427906
LINDQVIST D. ET AL.: "Increased plasma levels of circulating cell -free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity", TRANSL PSYCHIATRY, vol. 6, no. 12, 6 December 2016 (2016-12-06), pages 971, XP055550440
See also references of EP 3438281A4
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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