Title:
STROMAL CELL LAYER AROUND INTESTINAL ORGANOID FOR ENHANCING ENGRAFTMENT AND REGENERATION EFFICACY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/063531
Kind Code:
A1
Abstract:
The present invention relates to mature intestinal organoid-derived mesenchymal stromal cells, and a use thereof. The mature intestinal organoid-derived mesenchymal stromal cells according to the present invention can act directly on a lesion site to significantly enhance regeneration and engraftment efficacy, and thus can significantly enhance the efficiency of transplantation. Further, the mature intestinal organoid-derived mesenchymal stromal cells according to the present invention have excellent efficacy due to being capable of regenerating damaged regions immediately and directly, unlike conventional mesenchymal stem cell therapeutic agents, allow for the application of a simplified subculture method, can maintain the characteristics thereof even when frozen and thawed, and can be utilized in allogeneic transplantation, thus having the advantage of a high likelihood of universal applicability.
Inventors:
SON MI-YOUNG (KR)
LEE HANA (KR)
HAN TAE-SU (KR)
LEE HANA (KR)
HAN TAE-SU (KR)
Application Number:
PCT/KR2023/014264
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N5/077; A61K35/28; A61K35/38; A61K47/34; A61K47/42; A61P1/04; C12N5/071
Foreign References:
| EP3909594A1 | 2021-11-17 | |||
| KR20210070349A | 2021-06-14 | |||
| US20120276067A1 | 2012-11-01 | |||
| CN112823012A | 2021-05-18 |
Other References:
SUN HONGXIANG, TAN JIANMEI, CHEN HONGQIAN, WU NINGBO, SU BING: "Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 13, 3 November 2022 (2022-11-03), Lausanne, CH , pages 1057932, XP093149643, ISSN: 1664-3224, DOI: 10.3389/fimmu.2022.1057932
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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