Title:
STRUCTURE FOR COMPOUND SCAVENGING
Document Type and Number:
WIPO Patent Application WO/2023/127849
Kind Code:
A1
Abstract:
The present invention provides a structure for scavenging a compound, the structure including at least one gene from a gene group involved in the intracellular/extracellular transport of the compound, a product of the gene, or a combination of the gene and product.
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Inventors:
MATSUMOTO TAKASHI (JP)
SATO TAKASHI (JP)
SATO TAKASHI (JP)
Application Number:
PCT/JP2022/048101
Publication Date:
July 06, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
RIGAKU DENKI CO LTD (JP)
International Classes:
C12N15/31; C07K14/195; C07K14/37; C07K14/415; C07K14/435; C12N15/12; C12N15/29; C12P21/02
Other References:
MATSUMOTO TAKASHI; NAKASHIMA RYOSUKE; YAMANO AKIHITO; NISHINO KUNIHIKO: "Development of a structure determination method using a multidrug-resistance regulator protein as a framework", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 518, no. 2, 17 August 2019 (2019-08-17), Amsterdam NL , pages 402 - 408, XP085787408, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.08.070
YAMASAKI SUGURU, NIKAIDO EIJI, NAKASHIMA RYOSUKE, SAKURAI KEISUKE, FUJIWARA DAISUKE, FUJII IKUO, NISHINO KUNIHIKO: "The crystal structure of multidrug-resistance regulator RamR with multiple drugs", NATURE COMMUNICATIONS, vol. 4, no. 1, 26 June 2013 (2013-06-26), pages 3078, XP093074566, DOI: 10.1038/ncomms3078
NISHINO KUNIHIKO: "Physiological Role of Bacterial Multidrug EŒux Pumps", YAKUGAKU ZASSHI, THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 132, no. 1, 1 January 2012 (2012-01-01), pages 45 - 50, XP093074569
NISHINO KUNIHIKO, AKIHITO YAMAGUCHI: "Physiological functions of drug efflux systems in Gram-negative bacteria: Their roles in bacterial drug resistance and virulence", vol. 56, no. 4, 1 July 2008 (2008-07-01), pages 443 - 452, XP093075003
YOSHIDA HIROAKI: "Mechanisms of bacterial resistance to quinolones", JAPANESE JOURNAL OF BACTERIOLOGY., vol. 51, no. 4, 1 January 1996 (1996-01-01), pages 973 - 992, XP093075004
YAMASAKI SUGURU, NIKAIDO EIJI, NAKASHIMA RYOSUKE, SAKURAI KEISUKE, FUJIWARA DAISUKE, FUJII IKUO, NISHINO KUNIHIKO: "The crystal structure of multidrug-resistance regulator RamR with multiple drugs", NATURE COMMUNICATIONS, vol. 4, no. 1, 26 June 2013 (2013-06-26), pages 3078, XP093074566, DOI: 10.1038/ncomms3078
NISHINO KUNIHIKO: "Physiological Role of Bacterial Multidrug EŒux Pumps", YAKUGAKU ZASSHI, THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 132, no. 1, 1 January 2012 (2012-01-01), pages 45 - 50, XP093074569
NISHINO KUNIHIKO, AKIHITO YAMAGUCHI: "Physiological functions of drug efflux systems in Gram-negative bacteria: Their roles in bacterial drug resistance and virulence", vol. 56, no. 4, 1 July 2008 (2008-07-01), pages 443 - 452, XP093075003
YOSHIDA HIROAKI: "Mechanisms of bacterial resistance to quinolones", JAPANESE JOURNAL OF BACTERIOLOGY., vol. 51, no. 4, 1 January 1996 (1996-01-01), pages 973 - 992, XP093075004
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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