STRUCTURED ANTISENSE NUCLEIC ACID MOLECULES

Title:

STRUCTURED ANTISENSE NUCLEIC ACID MOLECULES

Document Type and Number:

WIPO Patent Application WO1999067379

Kind Code:

A3

Abstract:

The present invention relates to an antisense nucleic acid molecule comprising a first region and a second region, both of which are complementary to a target nucleic acid molecule, and wherein the first region is available for hybridisation and the second region is temporarily masked. The antisense molecules of the invention display increased specificity and stability of binding.

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Inventors:

STOCKS MARTIN (GB)
RABBITTS TERENCE (GB)

Application Number:

PCT/GB1999/001956

Publication Date:

August 24, 2000

Filing Date:

June 23, 1999

Export Citation:

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Assignee:

MEDICAL RES COUNCIL (GB)
STOCKS MARTIN (GB)
RABBITTS TERENCE (GB)

International Classes:

A61K31/7088; C12N15/09; A61K48/00; A61P35/00; C12N15/113; A61K38/00; (IPC1-7): C12N15/11; A61K31/70

Domestic Patent References:

WO1994001550A1	1994-01-20
WO1995029241A2	1995-11-02

Other References:

TANG J Y ET AL: "SELF-STABILIZED ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES: PROPERTIES AND ANTI-HIV ACTIVITY", NUCLEIC ACIDS RESEARCH, vol. 21, no. 11, 1993, pages 2729-2735, XP002030620, ISSN: 0305-1048
KRONENWETT R ET AL: "KINETIC SELECTIVITY OF COMPLEMENTARY NUCLEIC ACIDS: BCR-ABL-DIRECTED ANTISENSE RNA AND RIBOZYMES", JOURNAL OF MOLECULAR BIOLOGY, vol. 259, no. 4, pages 632-644, XP002051230, ISSN: 0022-2836

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