Title:
STRUCTURES OF PROTEASOME INHIBITORS AND METHODS FOR SYNTHESIZING AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/008204
Kind Code:
A3
Abstract:
Disclosed herein are novel structures of proteasome inhibitors and methods for synthesizing and use thereof, including novel structures of proteasome inhibitors, such as syrbactins and its analogs, and methods for synthesizing them and using them for effective proteasome inhibition.
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Inventors:
ENGELKING JARRED ROY (US)
TAFT KARL MILTON (US)
TAFT KARL MILTON (US)
Application Number:
PCT/US2013/048966
Publication Date:
February 27, 2014
Filing Date:
July 01, 2013
Export Citation:
Assignee:
PONO CORP (US)
International Classes:
C07D225/02; A61K31/33; A61P35/00; C07C49/307; C07D245/02; C07D285/00
Domestic Patent References:
| WO2010081731A2 | 2010-07-22 | |||
| WO2011069045A2 | 2011-06-09 | |||
| WO2009065090A2 | 2009-05-22 |
Foreign References:
| US20100022767A1 | 2010-01-28 | |||
| EP0437244A1 | 1991-07-17 | |||
| US4742047A | 1988-05-03 | |||
| US4393245A | 1983-07-12 | |||
| US3754036A | 1973-08-21 |
Other References:
JUN FU ET AL.: "Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.", NATURE BIOTECHNOLOGY, vol. 30, no. 5, 2012, pages 440 - 446
MASAHISA OKA ET AL.: "Chemical Modification of the Antitumor Antibiotic Glidobactin.", THE JOURNAL OF ANTIBIOTICS, vol. 41, no. 12, 1988, pages 1812 - 1822
NICOLAOU K. C. ET AL.: "A New Method for the One-Step Synthesis of alpha,beta- Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 31, 2000, pages 7596 - 7597
CLERC, JEROME ET AL.: "Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors.", EUR. J. ORG. CHEM., 2010, pages 3991 - 4003
PIRRUNG, MICHAEL C. ET AL.: "Total Synthesis of Syringolin A.", ORGANIC LETTERS, vol. 12, no. 10, 2010, pages 2402 - 2405
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 30293-82-4, "DB CAS, alanine tret-butyl ester (CAS 21691-50-9), methyl-(2S)-2- isocyanatopropanoate"
MASAHISA OKA ET AL.: "Chemical Modification of the Antitumor Antibiotic Glidobactin.", THE JOURNAL OF ANTIBIOTICS, vol. 41, no. 12, 1988, pages 1812 - 1822
NICOLAOU K. C. ET AL.: "A New Method for the One-Step Synthesis of alpha,beta- Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 31, 2000, pages 7596 - 7597
CLERC, JEROME ET AL.: "Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors.", EUR. J. ORG. CHEM., 2010, pages 3991 - 4003
PIRRUNG, MICHAEL C. ET AL.: "Total Synthesis of Syringolin A.", ORGANIC LETTERS, vol. 12, no. 10, 2010, pages 2402 - 2405
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 30293-82-4, "DB CAS, alanine tret-butyl ester (CAS 21691-50-9), methyl-(2S)-2- isocyanatopropanoate"
Attorney, Agent or Firm:
CHRISTENSEN, Michael, R. (LLP2040 Main Street, 14th Floo, Irvine CA, US)
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