Title:
SUBLINGUAL TABLET AND APPLICATION THEREOF IN DESENSITIZATION THERAPY DRUG
Document Type and Number:
WIPO Patent Application WO/2024/027519
Kind Code:
A1
Abstract:
The present invention relates to a sublingual tablet and an application thereof in a desensitization therapy drug. The sublingual tablet of the present invention is a low-dose allergen sublingual tablet. The sublingual tablet comprises allergen protein freeze-dried powder, the rest being lactose, mannitol, low-substituted hydroxypropyl cellulose, low-moisture microcrystalline cellulose, and magnesium stearate. According to the allergen protein sublingual tablet of the present invention, the allergen protein freeze-dried powder is obtained by using a freeze-drying process, and the tablet is obtained by using a powder direct tabletting process. The low-dose sublingual tablet of the present invention has excellent parameters, comprising characters, hardness, tablet weight variation, disintegration time limit, taste, and uniformity of content, in particular has outstanding advantages in terms of disintegration time limit, uniformity of content, stability, and preparation process, and has an industrial application prospect.
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Inventors:
MA YONG (CN)
WANG RONG (CN)
WANG JUN (CN)
XU YONG (CN)
WANG HE (CN)
WANG RONG (CN)
WANG JUN (CN)
XU YONG (CN)
WANG HE (CN)
Application Number:
PCT/CN2023/108667
Publication Date:
February 08, 2024
Filing Date:
July 21, 2023
Export Citation:
Assignee:
ZONHONBIOPHARMA INST INC (CN)
International Classes:
A61K9/20; A61P37/00; A61P37/08
Domestic Patent References:
| WO2021127722A1 | 2021-07-01 |
Foreign References:
| IN6103CHN2014A | ||||
| JP2020164517A | 2020-10-08 | |||
| CN114053402A | 2022-02-18 | |||
| CN108607096A | 2018-10-02 |
Other References:
WEN-JUAN YANG, DONG YANG-YANG; PAN MEI-LING; WANG LAN; GONG PIN: "Study on formulations screening of vitamin C orally disintegrating tablets", JOURNAL OF SHAANXI UNIVERSITY OF SCIENCE & TECHNOLOGY, vol. 35, no. 5, 25 October 2017 (2017-10-25), pages 151 - 155, XP093136265, DOI: 10.19481/j.cnki.issn2096-398x.2017.05.027
MACLEAN NATALIE; WALSH ERIN; SOUNDARANATHAN MITHUSHAN; KHADRA IBRAHIM; MANN JAMES; WILLIAMS HELEN; MARKL DANIEL: "Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 599, 2 February 2021 (2021-02-02), NL , XP086531634, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.120221
MACLEAN NATALIE; WALSH ERIN; SOUNDARANATHAN MITHUSHAN; KHADRA IBRAHIM; MANN JAMES; WILLIAMS HELEN; MARKL DANIEL: "Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 599, 2 February 2021 (2021-02-02), NL , XP086531634, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.120221
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