Title:
SUBSTANCE FOR PROMOTING REGENERATION AND REPAIR OF ORGANS OF MAMMALS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241717
Kind Code:
A1
Abstract:
Provided is use of a substance capable of up-regulating ISG gene expression in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The substance for up-regulating ISG gene expression is selected from one or two or more of an MAPK inhibitor, a retinoic acid receptor-related orphan receptor inhibitor, a protein synthesis inhibitor, and an interferon (IFNγ, β, λ) or alarmin (S100A8/A9) protein. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.
Inventors:
LI WEI (CN)
ZHOU QI (CN)
HE ZHENG-QUAN (CN)
LU ZONGBAO (CN)
WANG SHUAI (CN)
WANG XIN (CN)
YUAN XUEWEI (CN)
WANG LIU (CN)
ZHOU QI (CN)
HE ZHENG-QUAN (CN)
LU ZONGBAO (CN)
WANG SHUAI (CN)
WANG XIN (CN)
YUAN XUEWEI (CN)
WANG LIU (CN)
Application Number:
PCT/CN2023/100868
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
INST ZOOLOGY CAS (CN)
BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE (CN)
BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE (CN)
International Classes:
A61K31/381; A61P17/02; A61P17/14; A61P21/00; A61P25/00; C07D211/88
Domestic Patent References:
| WO2000026188A1 | 2000-05-11 | |||
| WO2016084790A1 | 2016-06-02 | |||
| WO2019108072A1 | 2019-06-06 |
Foreign References:
| RU2527701C1 | 2014-09-10 | |||
| US20150203475A1 | 2015-07-23 |
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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