Title:
SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-a] PYRIMIDINE AND IMIDAZO [1, 2-b] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2019/174598
Kind Code:
A1
Abstract:
Provided are certain TRK inhibitors, pharmaceutical compositions thereof, and methods of use thereof.
Inventors:
LIU HONGBIN (CN)
TAN HAOHAN (CN)
HE CHENGXI (CN)
WANG XIANLONG (CN)
LIU QIHONG (CN)
LI ZHIFU (CN)
ZHOU ZUWEN (CN)
GAO YUWEI (CN)
JIANG LIHUA (CN)
LINGHU LI (CN)
LIN SHU (US)
ZHAO XINGDONG (CN)
WANG WEIBO (US)
TAN HAOHAN (CN)
HE CHENGXI (CN)
WANG XIANLONG (CN)
LIU QIHONG (CN)
LI ZHIFU (CN)
ZHOU ZUWEN (CN)
GAO YUWEI (CN)
JIANG LIHUA (CN)
LINGHU LI (CN)
LIN SHU (US)
ZHAO XINGDONG (CN)
WANG WEIBO (US)
Application Number:
PCT/CN2019/077976
Publication Date:
September 19, 2019
Filing Date:
March 13, 2019
Export Citation:
Assignee:
FOCHON PHARMACEUTICALS LTD (CN)
SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN)
SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00; C07D471/04; C07D519/00
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BRICKNER, S J ET AL., J MED CHEM, vol. 39, no. 3, 1996, pages 673
MALLESHAM, B ET AL., ORG LETT, vol. 5, no. 7, pages 963
BLAKE ET AL., J. PHARM. SCI., vol. 64, no. 3, 1975, pages 367 - 391
FOSTER ET AL.: "Advances in Drug Research", vol. 14, 1985, ACADEMIC PRESS, pages: 2 - 36
KATO ET AL., J. LABELLED COMP. RADIOPHARMACEUT., vol. 36, no. 10, 1995, pages 927 - 932
KUSHNER ET AL., CAN. J. PHYSIOL. PHARMACOL, vol. 77, 1999, pages 79 - 88
CZAJKA D MFINKEL A J, ANN. N.Y. ACAD. SCI., vol. 84, 1960, pages 770
THOMSON J F, ANN. NEW YORK ACAD. SCI, vol. 84, 1960, pages 736
CZAKJA D M ET AL., AM. J. PHYSIOL., vol. 201, 1961, pages 357
BLAGOJEVIC N ET AL.: "Dosimetry & Treatment Planning for Neutron Capture Therapy", 1994, ADVANCED MEDICAL PUBLISHING, pages: 125 - 134
DIABETES METAB, vol. 23, 1997, pages 251
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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