SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS

Title:

SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2003027094

Kind Code:

A3

Abstract:

The invention provides novel substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof. The invention also provides methods of use of substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17 alpha -hydroxylase-C17,20-lyase enzyme. The invention further provides methods for the treatment of cancer in a subject, comprising administering a substituted 3-pyridyl indoles and indazoles or a pharmaceutical composition comprising a substituted 3-pyridyl indoles and indazoles to a subject. The cancer can be, e.g., prostate cancer or breast cancer.

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Inventors:

LADOUCEUR GAETAN H (US)
BURKE MICHAEL J (US)
WONG WAI C (US)
BIERER DONALD (US)

Application Number:

PCT/US2002/030482

Publication Date:

October 23, 2003

Filing Date:

September 26, 2002

Export Citation:

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Assignee:

BAYER PHARMACEUTICALS CORP (US)
LADOUCEUR GAETAN H (US)
BURKE MICHAEL J (US)
WONG WAI C (US)
BIERER DONALD (US)

International Classes:

C07D401/04; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/506; A61K31/519; A61K31/5377; A61P5/38; A61P9/12; A61P13/08; A61P15/00; A61P31/10; A61P35/00; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D413/04; C07D413/14; C07D417/04; C07D417/06; C07D417/14; C07D513/04; (IPC1-7): C07D401/04; A61K31/404; A61K31/416; A61K31/422; A61P35/00; C07D401/14

Domestic Patent References:

WO1993015049A1	1993-08-05
WO1993018008A1	1993-09-16

Foreign References:

US5928998A	1999-07-27
EP0126401A1	1984-11-28
US5395817A	1995-03-07
EP0544218A1	1993-06-02
US6046136A	2000-04-04

Other References:

DN GRIGORYEV, BJ LONG, IP NANE,VCO NJAR, Y LIU AND AMH BRODIE: "Effects of new 17alpha-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo", BRITISH JOURNAL OF CANCER, vol. 81, no. 4, 1999, pages 622 - 630, XP009001303
YAN ZHUANG AND ROLF W. HARTMANN: "Synthesis and Evaluation of Azole-substituted 2-Aryl-6-methoxy-3,4-dihydronaphthalenes and -naphthalenes as Inhibitors of 17 alpha-Hydroxylase-C17,20-Lyase (P450 17)", ARCH. PHARM. PHARM. MED. CHEM., vol. 332, 1999, pages 25 - 30, XP002222972

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