Title:
SUBSTITUTED 4-PHENYL-PIPERIDIN-AMIDES AS TACHYKININ ANTAGONISTS AND SEROTONIN REPTAKE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004005256
Kind Code:
A3
Abstract:
The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy;R2 represents hydrogen or C1-4 alkyl;R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl;R5 represents trifluoromethyl, S(O)t C 1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano;R6 represents hydrogen or (CH2)rR7;R7 represents hydrogen, C3-7 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2 , OC(O)NR9R8 , NR8C(O)R9 or C(O)NR9R8;R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4;n represents 1 or 2;p is zero or an integer from 1 to 3;q is an integer from 1 to 3;r is an integer from 1 to 4;t is 0 , 1 or 2 ;provided that when m is 0, p is 2, q , r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein .
Inventors:
ALVARO GIUSEPPE (IT)
CARDULLO FRANCESCA (IT)
DI FABIO ROMANO (IT)
GIOVANNINI RICCARDO (IT)
PIGA ELISABETTA (IT)
TRANQUILLINI MARIA ELVIRA (IT)
CARDULLO FRANCESCA (IT)
DI FABIO ROMANO (IT)
GIOVANNINI RICCARDO (IT)
PIGA ELISABETTA (IT)
TRANQUILLINI MARIA ELVIRA (IT)
Application Number:
PCT/EP2003/007127
Publication Date:
October 14, 2004
Filing Date:
July 02, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
ALVARO GIUSEPPE (IT)
CARDULLO FRANCESCA (IT)
DI FABIO ROMANO (IT)
GIOVANNINI RICCARDO (IT)
PIGA ELISABETTA (IT)
TRANQUILLINI MARIA ELVIRA (IT)
ALVARO GIUSEPPE (IT)
CARDULLO FRANCESCA (IT)
DI FABIO ROMANO (IT)
GIOVANNINI RICCARDO (IT)
PIGA ELISABETTA (IT)
TRANQUILLINI MARIA ELVIRA (IT)
International Classes:
A61K31/451; A61K31/55; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07D211/34; C07D211/64; C07D223/04; C07D223/06; (IPC1-7): C07D211/34; C07D211/64; C07D223/04; C07D223/06
Domestic Patent References:
| WO1994013639A1 | 1994-06-23 | |||
| WO1999059972A1 | 1999-11-25 | |||
| WO2000021931A1 | 2000-04-20 | |||
| WO2002083134A1 | 2002-10-24 | |||
| WO2003033486A1 | 2003-04-24 |
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