Title:
SUBSTITUTED AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/037192
Kind Code:
A1
Abstract:
Disclosed is a substituted amide represented by formula (I), which is useful as an active ingredient of a pharmaceutical composition, especially as an active ingredient of a pharmaceutical composition for the treatment of diseases that are induced by lysophosphatidic acid (LPA). (In the formula, A represents an optionally substituted aryl group or the like; B represents an optionally substituted aromatic five-membered heterocyclic group; X represents a single bond or a -(CRX1RX2)n- group; n represents 1, 2, 3 or 4; RX1 and RX2 each represents a hydrogen atom or the like; Y1-Y5 each represents a CRY group or N; RY represents a hydrogen atom or the like; R1 and R2 each represents a hydrogen atom or the like; m represents 1, 2 or 3; R3 represents a hydrogen atom or the like; and R4 represents an optionally substituted lower alkyl group or the like.)
Inventors:
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
FUKUDA YUTA (JP)
KAIZAWA HIROYUKI (JP)
KONDOH YUTAKA (JP)
SEO RYUSHI (JP)
KURAMOTO KAZUYUKI (JP)
TAKE KAZUHIKO (JP)
SAKAMOTO KAZUYUKI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
FUKUDA YUTA (JP)
KAIZAWA HIROYUKI (JP)
KONDOH YUTAKA (JP)
SEO RYUSHI (JP)
KURAMOTO KAZUYUKI (JP)
TAKE KAZUHIKO (JP)
SAKAMOTO KAZUYUKI (JP)
Application Number:
PCT/JP2010/066572
Publication Date:
March 31, 2011
Filing Date:
September 24, 2010
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
FUKUDA YUTA (JP)
KAIZAWA HIROYUKI (JP)
KONDOH YUTAKA (JP)
SEO RYUSHI (JP)
KURAMOTO KAZUYUKI (JP)
TAKE KAZUHIKO (JP)
SAKAMOTO KAZUYUKI (JP)
KAWAMINAMI EIJI (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
FUKUDA YUTA (JP)
KAIZAWA HIROYUKI (JP)
KONDOH YUTAKA (JP)
SEO RYUSHI (JP)
KURAMOTO KAZUYUKI (JP)
TAKE KAZUHIKO (JP)
SAKAMOTO KAZUYUKI (JP)
International Classes:
A61K31/341; C07D207/34; A61K31/381; A61K31/401; A61K31/415; A61K31/42; A61K31/426; A61K31/427; A61K31/433; A61K31/44; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/4965; A61K31/505; A61K31/506; A61K31/5377; A61K31/538; A61K31/541; A61P9/00; A61P13/00; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D213/81; C07D231/12; C07D239/28; C07D241/24; C07D261/18; C07D263/32; C07D263/34; C07D277/20; C07D277/30; C07D277/56; C07D307/68; C07D333/24; C07D333/28; C07D333/38; C07D417/12
Domestic Patent References:
| WO2005058790A1 | 2005-06-30 | |||
| WO2006001463A1 | 2006-01-05 | |||
| WO2002062389A1 | 2002-08-15 | |||
| WO2004031118A1 | 2004-04-15 | |||
| WO2005058790A1 | 2005-06-30 | |||
| WO1999019513A2 | 1999-04-22 |
Foreign References:
| JP2009523774A | 2009-06-25 |
Other References:
PROC NATL ACAD SCI U. S. A., vol. 103, 2006, pages 9643
BIOCHIM BIOPHYS ACTA, vol. 1801, 2010, pages 1205
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"The Chemical Society of Japan", vol. 16, 2005, MARUZEN, article "Courses in Experimental Chemistry"
"The Chemical Society of Japan", vol. 14, 2005, MARUZEN, article "Courses in Experimental Chemistry"
SYNTHESIS, vol. 4, 2006, pages 629 - 632
FALCK ET AL., TETRAHEDRON LETT., vol. 35, 1994, pages 5997
LIU ET AL., SYNTHESIS, vol. 14, 2001, pages 2078 - 2080
PLOUVIER ET AL., HETEROCYCLES, vol. 32, 1991, pages 693
JOHNSON ET AL., TETRAHEDRON LETT., vol. 45, 2004, pages 8483 - 8487
LESAC ET AL., TETRAHEDRON ASYMMETRY, vol. 14, 2003, pages 2731 - 2737
See also references of EP 2481725A4
BIOCHIM BIOPHYS ACTA, vol. 1801, 2010, pages 1205
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"The Chemical Society of Japan", vol. 16, 2005, MARUZEN, article "Courses in Experimental Chemistry"
"The Chemical Society of Japan", vol. 14, 2005, MARUZEN, article "Courses in Experimental Chemistry"
SYNTHESIS, vol. 4, 2006, pages 629 - 632
FALCK ET AL., TETRAHEDRON LETT., vol. 35, 1994, pages 5997
LIU ET AL., SYNTHESIS, vol. 14, 2001, pages 2078 - 2080
PLOUVIER ET AL., HETEROCYCLES, vol. 32, 1991, pages 693
JOHNSON ET AL., TETRAHEDRON LETT., vol. 45, 2004, pages 8483 - 8487
LESAC ET AL., TETRAHEDRON ASYMMETRY, vol. 14, 2003, pages 2731 - 2737
See also references of EP 2481725A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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