SUBSTITUTED AMIDE DERIVATIVE - BANYU PHARMA CO LTD

Title:

SUBSTITUTED AMIDE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1996/005168

Kind Code:

A1

Abstract:

A compound represented by general formula (I), a medicinally acceptable salt or ester thereof, and an antineoplastic containing the same as the active ingredient, wherein Ar1, Ar2 and Ar3 represent each aryl or heteroaryl; A represents an optionally substituted hydrocarbon group; Q represents -(CH2)m- (m being an integer of 1 to 6) or -(CH2)n-W-(CH2)p- (W being oxygen, sulfur, vinylene or ethynylene; and n and p being each an integer of 0 to 3); R1 represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkoxy, or optionally substituted aryl or heteroaryl; R2, R7 and R8 represent each hydrogen, halogeno, hydroxy, lower alkyl or lower alkoxy; R3 and R4 represent each hydrogen, halogeno, hydroxy, amino, nitro cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl or lower alkoxy; R5 represents lower alkyl; and R6 represents hydrogen or lower alkyl.

Inventors:

IWASAWA YOSHIKAZU (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)

Application Number:

PCT/JP1995/001588

Publication Date:

February 22, 1996

Filing Date:

August 10, 1995

Export Citation:

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Assignee:

BANYU PHARMA CO LTD (JP)
IWASAWA YOSHIKAZU (JP)
AOYAMA TETSUYA (JP)
KAWAKAMI KUMIKO (JP)
ARAI SACHIE (JP)
SATOH TOSHIHIKO (JP)
MONDEN YOSHIAKI (JP)

International Classes:

C07C233/05; C07C233/13; C07C233/18; C07C233/25; C07C233/36; C07D213/40; C07D215/12; C07D235/14; C07D263/56; C07D277/64; C07D307/81; C07D317/58; C07D333/58; C07D413/06; C07D413/12; C07D413/14; (IPC1-7): C07C233/13; C07C233/25; C07D213/40; C07D261/08; C07D307/68; C07D405/12; A61K31/19; A61K31/34; A61K31/42

Foreign References:

JPH05213992A	1993-08-24
JPH05279290A	1993-10-26

Other References: