Title:
SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2016/134668
Kind Code:
A1
Abstract:
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.
Inventors:
XI NING (US)
Application Number:
PCT/CN2016/074666
Publication Date:
September 01, 2016
Filing Date:
February 26, 2016
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
CALITOR SCIENCES LLC (US)
CALITOR SCIENCES LLC (US)
International Classes:
C07D413/14; A61K31/506; A61K31/517; A61P9/00; A61P11/00; A61P29/00; A61P31/12; A61P35/02; A61P37/00; A61P37/08; C07D401/14; C07D403/14
Domestic Patent References:
| WO2013116562A1 | 2013-08-08 | |||
| WO2013032591A1 | 2013-03-07 | |||
| WO2005095382A1 | 2005-10-13 | |||
| WO2015042077A1 | 2015-03-26 | |||
| WO2015042078A2 | 2015-03-26 |
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (Trade Building Zhaolanyuan, Tsinghua University, Qinghuayuan,Haidian District, Beijing 4, CN)
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