Title:
SUBSTITUTED AROMATIC FUSED RING DERIVATIVE AND COMPOSITION COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057877
Kind Code:
A1
Abstract:
Provided in the present invention are a substituted aromatic fused ring derivative, a composition comprising the compound, and the use thereof. The substituted aromatic fused ring derivative is a compound as shown as formula (I) or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound and the composition of the present invention can be used to treat various protein tyrosine kinase-mediated diseases or conditions.
Inventors:
WANG YIHAN (CN)
XING QINGFENG (CN)
AI YIXIN (CN)
LI HUANYIN (CN)
XING QINGFENG (CN)
AI YIXIN (CN)
LI HUANYIN (CN)
Application Number:
PCT/CN2020/117586
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
A61K31/41; C07D487/04; A61K31/519; A61K31/5377; A61P35/00; A61P35/02
Foreign References:
| CN111646995A | 2020-09-11 | |||
| CN1993361A | 2007-07-04 | |||
| CN107176951A | 2017-09-19 | |||
| US5376645A | 1994-12-27 |
Other References:
YUAN, XUE ET AL.: "Identification of Pyrrolo[2, 3-d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3(FLT3) Inhibitors for Treating Acute Myelogenous Leukemia", J. MED. CHEM., vol. 62, no. 8, 2 April 2019 (2019-04-02), XP055742629, ISSN: 1520-4804, DOI: 20201109094940X
BERGE ET AL.: "pharmaceutically acceptable salts", J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
T. HIGUCHIV. STELLA: "Prodrugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987
D. FLEISHERS. RAMONH. BARBRA: "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADVANCED DRUG DELIVERY REVIEWS, vol. 19, no. 2, 1996, pages 115 - 130
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
See also references of EP 4043465A4
BERGE ET AL.: "pharmaceutically acceptable salts", J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
T. HIGUCHIV. STELLA: "Prodrugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987
D. FLEISHERS. RAMONH. BARBRA: "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADVANCED DRUG DELIVERY REVIEWS, vol. 19, no. 2, 1996, pages 115 - 130
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
See also references of EP 4043465A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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