Title:
SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS
Document Type and Number:
WIPO Patent Application WO2006076575
Kind Code:
B1
Abstract:
The present invention provides compounds of Formula: (I); or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Inventors:
CORTE JAMES R (US)
QUAN MIMI L (US)
SMALLHEER JOANNE M (US)
PINTO DONALD J (US)
QUAN MIMI L (US)
SMALLHEER JOANNE M (US)
PINTO DONALD J (US)
Application Number:
PCT/US2006/001224
Publication Date:
November 30, 2006
Filing Date:
January 12, 2006
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
CORTE JAMES R (US)
QUAN MIMI L (US)
SMALLHEER JOANNE M (US)
PINTO DONALD J (US)
CORTE JAMES R (US)
QUAN MIMI L (US)
SMALLHEER JOANNE M (US)
PINTO DONALD J (US)
International Classes:
A61P7/02; C07C237/24; C07D261/20
Download PDF:
Previous Patent: ENHANCED EFFICACY ANTIPERSPIRANT ACTIVE
Next Patent: ENVIRONMENTALLY RESILIENT CORRUGATED BUILDING PRODUCTS AND METHODS OF MANUFACTURE
Next Patent: ENVIRONMENTALLY RESILIENT CORRUGATED BUILDING PRODUCTS AND METHODS OF MANUFACTURE