SUBSTITUTED BICYCLIC HETEROARYL COMPOUND AS USP1 INHIBITOR

Title:

SUBSTITUTED BICYCLIC HETEROARYL COMPOUND AS USP1 INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2023/216910

Kind Code:

A1

Abstract:

Provided in the present invention is a new substituted bicyclic heteroaryl compound as represented by formula (A), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof as a USP1 inhibitor. Further provided in the present invention are a method for preparing the compound, a pharmaceutical composition comprising the compound, and the use of the compound in the prevention and treatment of related cancers.

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Inventors:

LIU BIN (CN)
GAO FENG (CN)
GUO YONGQI (CN)
JING LIANDONG (CN)
WU YONGYONG (CN)
WANG JING (CN)
ZHANG PENGZHI (CN)
LI ZHIZHONG (CN)
GAO YU (CN)
WU ZHUO (CN)

Application Number:

PCT/CN2023/091338

Publication Date:

November 16, 2023

Filing Date:

April 27, 2023

Export Citation:

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Assignee:

SUZHOU PUHE BIOPHARMA CO LTD (CN)

International Classes:

C07D487/04; A61K31/519; A61P35/00; C07D273/00; C07D291/08; C07D417/14

Domestic Patent References:

WO2022214053A1	2022-10-13
WO2022216820A1	2022-10-13

Foreign References:

CN102762565A	2012-10-31
CN102762568A	2012-10-31
CN106132965A	2016-11-16
CN1503797A	2004-06-09
US20090099171A1	2009-04-16

Attorney, Agent or Firm:

LIU , SHEN & ASSOCIATES (CN)

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