Title:
SUBSTITUTED CARBINOL COMPOUND HAVING CYCLIC LINKER
Document Type and Number:
WIPO Patent Application WO/2009/144961
Kind Code:
A1
Abstract:
Disclosed is a novel LXRβ agonist which is useful as a prophylactic and/or therapeutic agent for arteriosclerosis such as atherosclerosis and arteriosclerosis associated with diabetes, dyslipidemia, hypercholesterolemia, lipid-related diseases, inflammatory diseases induced by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer’s disease. The LXRβ agonist is a carbinol compound represented by general formula (I), a salt of the carbinol compound, or a solvate of the carbinol compound or the salt.
Inventors:
YAMAGUCHI YUKI (JP)
KOURA MINORU (JP)
KUROBUCHI SAYAKA (JP)
MATSUDA TAKAYUKI (JP)
OKUDA AYUMU (JP)
SUMIDA HISASHI (JP)
WATANABE YUUICHIROU (JP)
ENOMOTO TAKASHI (JP)
SHIBUYA KIMIYUKI (JP)
KOURA MINORU (JP)
KUROBUCHI SAYAKA (JP)
MATSUDA TAKAYUKI (JP)
OKUDA AYUMU (JP)
SUMIDA HISASHI (JP)
WATANABE YUUICHIROU (JP)
ENOMOTO TAKASHI (JP)
SHIBUYA KIMIYUKI (JP)
Application Number:
PCT/JP2009/002406
Publication Date:
December 03, 2009
Filing Date:
May 29, 2009
Export Citation:
Assignee:
KOWA CO (JP)
YAMAGUCHI YUKI (JP)
KOURA MINORU (JP)
KUROBUCHI SAYAKA (JP)
MATSUDA TAKAYUKI (JP)
OKUDA AYUMU (JP)
SUMIDA HISASHI (JP)
WATANABE YUUICHIROU (JP)
ENOMOTO TAKASHI (JP)
SHIBUYA KIMIYUKI (JP)
YAMAGUCHI YUKI (JP)
KOURA MINORU (JP)
KUROBUCHI SAYAKA (JP)
MATSUDA TAKAYUKI (JP)
OKUDA AYUMU (JP)
SUMIDA HISASHI (JP)
WATANABE YUUICHIROU (JP)
ENOMOTO TAKASHI (JP)
SHIBUYA KIMIYUKI (JP)
International Classes:
C07D233/72; A61K31/4166; A61K31/4178; A61K31/4355; A61K31/4439; A61K31/444; A61K31/506; A61P3/06; A61P3/10; A61P9/10; A61P17/00; A61P25/28; A61P29/00; A61P43/00; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D405/04; C07D405/14; C07D491/048
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| WO2000054759A2 | 2000-09-21 | |||
| WO2005023782A1 | 2005-03-17 | |||
| WO2008065754A1 | 2008-06-05 | |||
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| WO2004072046A2 | 2004-08-26 | |||
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| JP2007284367A | 2007-11-01 | |||
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| JP2004509161A | 2004-03-25 | |||
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"Protective Groups in Organic Synthesis", JOHN WILEY & SONS. INC.
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
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"Comprehensive Organic Transformations", JOHN WILEY & SONS, INC.
TETRAHEDRON, vol. 21, 2005, pages 1813 - 1819
See also references of EP 2281817A4
LEHMANN ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 3137 - 3140
FU ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 38378 - 38387
AUBOEUF ET AL., DIABETES, vol. 46, 1997, pages 1319 - 1327
LU ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 37735 - 37738
ZELCER ET AL., J. CLIN. INVEST., vol. 116, 2006, pages 607 - 614
MANGELSDORF ET AL., NAT. MED., vol. 9, 2003, pages 213 - 219
GEYEREGGER ET AL., CELL. MOL. LIFE SCI., vol. 63, 2006, pages 524 - 539
PEET ET AL., CELL, vol. 93, 1998, pages 693 - 704
ALBERTI ET AL., J. CLIN. INVEST., vol. 107, 2001, pages 565 - 573
TANGIRALA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 11896 - 11901
TERASAKA ET AL., FEBS LETT., vol. 536, 2003, pages 6 - 11
CAO ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 1131 - 1136
LAFFITTE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 100, 2003, pages 5419 - 5424
LALA ET AL., CURR. OPIN. INVESTIG. DRUGS, vol. 6, 2005, pages 934 - 943
PIETER ET AL., J.LIPID RES., vol. 46, 2005, pages 2182 - 2191
SCHULTZ ET AL., GENES DEV., vol. 14, 2000, pages 2831 - 2838
LUND ET AL., ARTERIOSCLER.THROMB.VASC.BIOL., vol. 23, 2003, pages 1169 - 1177
BRADLEY ET AL., DRUG DISCOV. TODAY THER. STRATEG., vol. 2, 2005, pages 97 - 103
HU ET AL., J. MED. CHEM., vol. 49, 2006, pages 6151 - 6154
HU ET AL., BIOORG. MED. CHERN., vol. 15, 2007, pages 3321 - 3333
HU ET AL., BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 54 - 59
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS. INC.
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
TETRAHEDRON, vol. 56, 2000, pages 5045 - 5065
"Comprehensive Organic Transformations", JOHN WILEY & SONS, INC.
TETRAHEDRON, vol. 21, 2005, pages 1813 - 1819
See also references of EP 2281817A4
Attorney, Agent or Firm:
HIROTA, Masanori et al. (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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