SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

WIPO Patent Application WO/2002/046146

A1

Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor a (PPARa) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preventing effect, an anti-obesity effect, a hypoglycemic effect, etc.; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1) and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R?1¿, R?3¿ and R?5¿ represent each hydrogen or lower alkyl; R?2¿ represents hydrogen or lower alkoxy; R?4¿ represents hydrogen, trifluoromethyl, lower alkoxy, halogeno, optionally substituted phenoxy or benzyloxy; n is an integer of from 0 to 3; and the carboxylate substituent is located at the p-position concerning R?2¿ or at the p-position concerning (CH¿2?)¿n?.

MIYACHI HIROYUKI (JP)
TAKAHASHI YUKIE (JP)
MURAKAMI KOUJI (JP)

PCT/JP2001/010563

June 13, 2002

December 04, 2001

Click for automatic bibliography generation  

KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
TAKAHASHI YUKIE (JP)
MURAKAMI KOUJI (JP)

A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C275/30; C07C275/42; (IPC1-7): C07C275/28; A61K31/195; A61K31/216; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07C275/30; C07C275/34; C07C275/42

WO2000075103A1	2000-12-14
WO1999054321A1	1999-10-28

JP2000256194A

2000-09-19

Minoura, Kiyoshi (2-2 Kudankita 3-chome Chiyoda-ku, Tokyo, JP)

View/Download PDF      PDF Help

Previous Patent: TETRALONE DERIVATIVES AS ANTITUMOR AGENTS

Next Patent: PERTURBED MEMBRANE-BINDING COMPOUNDS