Title:
SUBSTITUTED CARBOXYLIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/046161
Kind Code:
A1
Abstract:
Novel substituted carboxylic acid derivatives which bind as ligand to human peroxisome proliferator activated receptor (PPAR) to activate the receptor and thereby exhibit potent effects of decreasing neutral fat, cholesterol, and blood sugar; and a process for preparing the derivatives. Specifically, substituted carboxylic acid derivatives represented by the general formula (1), and pharmaceutically acceptable salts and hydrates of the derivatives, and a process for preparing the derivatives, the salts, or the hydrates. (1)
Inventors:
MIYACHI HIROYUKI (JP)
MURAKAMI KOUJI (JP)
MURAKAMI KOUJI (JP)
Application Number:
PCT/JP2001/010564
Publication Date:
June 13, 2002
Filing Date:
December 04, 2001
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
MURAKAMI KOUJI (JP)
MIYACHI HIROYUKI (JP)
MURAKAMI KOUJI (JP)
International Classes:
A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/50; A61P3/04; A61P3/06; A61P3/10; A61P9/10; C07D213/40; C07D213/64; C07D213/73; C07D237/14; C07D401/12; (IPC1-7): C07D213/40; C07D213/56; C07D213/643; C07D213/75; C07D237/14; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/44; A61K31/50; A61P3/04; A61P3/06; A61P3/10; A61P9/10
Domestic Patent References:
| WO1997032863A1 | 1997-09-12 | |||
| WO1997025042A1 | 1997-07-17 | |||
| WO1997036579A1 | 1997-10-09 | |||
| WO2001025181A1 | 2001-04-12 | |||
| WO2001014349A1 | 2001-03-01 | |||
| WO2001014350A1 | 2001-03-01 | |||
| WO2000075103A1 | 2000-12-14 | |||
| WO2001021578A1 | 2001-03-29 |
Foreign References:
| EP0881219A1 | 1998-12-02 | |||
| JPS51136646A | 1976-11-26 |
Other References:
See also references of EP 1348698A4
Attorney, Agent or Firm:
Minoura, Kiyoshi (2-2 Kudankita 3-chome Chiyoda-ku, Tokyo, JP)
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