Title:
SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS
Document Type and Number:
WIPO Patent Application WO2003063781
Kind Code:
A3
Abstract:
Compounds of the present invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as, the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver. Particular novel compounds of structural formula (I) are also claimed.
Inventors:
HAGMANN WILLIAM K (US)
QI HONGBO (US)
SHAH SHRENIK K (US)
QI HONGBO (US)
SHAH SHRENIK K (US)
Application Number:
PCT/US2003/002351
Publication Date:
December 11, 2003
Filing Date:
January 24, 2003
Export Citation:
Assignee:
MERCK & CO INC (US)
HAGMANN WILLIAM K (US)
QI HONGBO (US)
SHAH SHRENIK K (US)
HAGMANN WILLIAM K (US)
QI HONGBO (US)
SHAH SHRENIK K (US)
International Classes:
A61K31/4164; A61K31/4178; A61K31/454; A61K31/496; A61K31/5377; A61K31/55; C07D233/90; (IPC1-7): A61K31/445; C07D401/12; C07D231/04
Domestic Patent References:
| WO1998031227A1 | 1998-07-23 |
Foreign References:
| US5624941A | 1997-04-29 | |||
| US6028084A | 2000-02-22 |
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