SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS

Title:

SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS

Document Type and Number:

WIPO Patent Application WO2006039356

Kind Code:

A8

Abstract:

The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R₁-R₈, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Inventors:

KEMNITZER WILLIAM E (US)
CAI SUI XIONG (US)
DREWE JOHN A (US)
SIRISOMA NILANTHA SUDATH (US)

Application Number:

PCT/US2005/034890

Publication Date:

April 26, 2007

Filing Date:

September 29, 2005

Export Citation:

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Assignee:

CYTOVIA INC (US)
KEMNITZER WILLIAM E (US)
CAI SUI XIONG (US)
DREWE JOHN A (US)
SIRISOMA NILANTHA SUDATH (US)

International Classes:

A61K31/34; A61K31/165; A61K31/38; A61K31/40

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