SUBSTITUTED PYRAZINE-2-CARBOX AMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

TECHNICAL FIELD

The technical field relates to certain substituted pyrazine 2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds of Formula (I) are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or amelioration of abnormal cell proliferative disorders such as cancer.

BACKGROUND

In recent years, discovery of immunological check points and their inhibition has unveiled a new avenue for targeting cancer by harnessing the body’s own immune system to fight tumours. While check point therapy has shown great promise in several tumour types, only a fraction of cancer patients respond, novel therapies are needed to reach a broader range of patients.

T cells are critical in the cancer immunity cycle (Nature, 541 (2017), 321-330; Nature Reviews Immunology, 20, (2020), 651-668); they are the effector cells which recognize and kill tumour cells. In cancer patients, T cells are driven to exhaustion in the tumour microenvironment by chronic exposure to antigen and become non -functional. Additionally, suppressive signals in the tumour such as PGE2, TGFβ, adenosine, etc. hamper the function of these cells. Therapies that enhance T cell function and rescue the function of exhausted T cells therefore result in improved tumour control.

HPKl (hematopoietic progenitor kinase 1), also known as mitogen activated protein kinase 1 MAP4K1, a Ste20-related serine/threonine kinase that is expressed only in hematopoietic cells acts as a negative regulator of T cell signalling and tumouricidal cytokine production. Following TCR ligation, HPKl phosphorylates its target SLP76 at Ser376 causing SLP76 to associate with 14-3-3 which results in disassociation of the LAT signalosome (J. Cell Biol., 195 (2011), 839-853; Nat. Immunol., 8 (2007), 84-91) and thus restricts T cell activation (J. Exp. Med., 204 (2007), 681-91). Loss of HPKl or inactive kinase (kinase dead) causes enhanced activation of T cells resulting in increased cytokine secretion and proliferation (Nat Immunol., 8. (2007), 84-91; Cell Reports, 25 (2018), 80-94). HPKl can also inhibit T cell signalling in response to immunosuppressive prostaglandin E2 (PGE2) through protein kinase A (PKA) (Blood, 101 (2003), 3687-89; J. Biol. Chem., 282 (2007), 34693-99; Cancer Immunol. Immunother., 59 (2010), 419-29). Recent literature has described the essential function of the kinase domain of HPK1 in driving tumour surveillance, inactivation of the kinase domain of HPK1 prevents tumour progression in murine tumour models. Importantly, studies comparing wildtype and kinase dead mice show that loss of kinase function of HPK1 can rescue T cells from exhaustion in chronic viral infection and PGE2 high tumour models (Nat Immunol., 8. (2007), 84-91; Cell Reports, 25 (2018), 80-94). Apart from its function in T cells, HPK1 is also reported to act as a negative regulator in other immune cells such as B cells, dendritic cells and NK cells which would also contribute to tumour immunity (Elife, 2020, 9). The kinase activity of HPK1 has been implicated as essential for the regulation of T cell function (Cell Reports, 25 (2018), 80-94), supporting the development of small molecule inhibitors of HPK1 for use in cancer immunotherapy to boost T cell function as well as other immune cell types. HPK1 protein contains an N-terminal kinase domain, which is the regulatory domain containing the ATP binding site amino acids 23-46 (EMBO J., 15, 1996, 7013-25). The intermediate domain has proline-rich motifs with binding sites for SH3- containing proteins such as Crkl, Grb2 and HIP-55 which suggests a scaffolding function. The Citron homology domain is at the C-terminal which may act as a regulatory domain in molecular interactions including T cell adhesion. LCK and ZAP70 induce HPK1 Tyr-379 phosphorylation and kinase activation (Oncogene, 20 (2001), 1703-14; Immunity, 12 (2000), 399-408; J. Biol. Chem., 276 (2001), 45207-16. Essential adapters for T cell (SLP76) and B cell (BLNK) signalling have been reported to bind to activated HPK1 aiding in blockade of downstream signalling in both T and B cells (J. Biol. Chem., 276 (2001), 18908-14). Collectively there is strong rationale for targeting HPK1 with small molecule kinase inhibitors for cancer immunotherapy.

An HPK1 inhibitor can be used alone or in combination with other therapeutic agents for the treatment of cancer. An HPK1 inhibitor could be used in combination with check point blockade PD-(L)1 axis or with CTLA4 in efforts to expand response rates to check point blockade. Primary or secondary resistance to check point blockade may be potential indications for an HPK1 inhibitor. Additional combinations may include radiation, chemotherapy, surgery, tumour targeted agents or other immune targeted agents.

An HPK1 inhibitor could be used as a therapeutic in multiple cancer indications. A number of small molecule inhibitors of HPK1 have been disclosed in patent applications, for example as summarized in Expert Opinion on Therapeutic Patents, DOI: 10.1080/13543776.2021.1924671.

WO2016/205942 HPK1 inhibitors and methods of using same WO2018/167147 Azaindoles as inhibitors of HPK1 W02020/061377 Spirocyclic 2,3-dihydro-7-azaindoles and uses there of WO2018/183964 Isoquinolines as inhibitors of HPK1 W02020/023551 Naphthyridine compounds and uses thereof W02020/023560 Isoquinoline compounds and uses thereof

W02020/069402 Cinnoline compounds and for the treatment of HPK1 -dependent disorders such as cancer

W02020/072627 Isoquinoline compounds for the treatment of cancer W02020/072695 8-Aminoisoquinoline compounds and uses thereof W02018/081531 Methods for Human T-cell activation

WO2018/102366 Anilinopyrimidines as Haematopoietic progenitor kinase 1 (HPK1) inhibitors

WO2018/228923 Substituted pyrrolopyridine-derivatives as MAP4K1 modulators for the treatment of cancer diseases

WO20 18/228920 Preparation of substituted pyrrol opyri dine derivatives as anticancer agents WO20 18/228925 Preparation of substituted pyrrol opyri dine derivatives as anticancer agents WO20 19/016071 Substituted pyrrol opyridine derivatives W02020/120257 Substituted pyrrolopyridine derivatives

W02020/092528 Substituted 6-azabenzimidazole compounds having HPKl inhibitory activity

W02020/092621 Substituted 6-azabenzimidazole compounds as HPKl inhibitors W02020/237025 Substituted exo-methylene-oxindoles which are HPK1/MAP4K1 inhibitors W02020/193511 HPKl inhibitors WO2020/193512 Bicyclic HPKl inhibitors

W02020/1000272,3-Dihydro-lH-pyrrolo[3,4-C]pyridine-l-one derivatives as HPKl inhibitors for the treatment of cancer W02020/070331 Indoline compounds for use as MAP4K1 inhibitors W02020/070332 Oxindole compounds for use as MAP4K1 inhibitors WO2019/238067 Pyrrolo[2,3-b]pyridines or pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof

W02020/103896 Pyrrolo[2,3-b]pyridines as HPK1 inhibitor and uses thereof W02021/000925 Pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof W02021013083 Tricyclic compounds as HPK1 inhibitor and use thereof WO2021032148 Aminopyrazine compounds as HPK1 inhibitor and the use thereof WO202 1/000935 HPK1 inhibitors and uses thereof

W02019/206049 HPK1 inhibitors, preparation method and application thereof WO2020/227325 Heterobifunctional Compounds as Degraders of HPK1 WO 2019/090198 Isofuranone compounds useful as HPK1 inhibitors in the treatment of cancer and viral infections and their preparation

WO 2018/049152 Preparation of pyrazolopyrimidine derivatives as HPK1 modulators and their use for the treatment of cancer

WO 2018/049191 Pyrazolopyridone derivatives as HPK1 modulator and uses thereof for the treatment of cancer

WO 2018/049200 Pyrazolopyridine derivatives as HPK1 modulator and uses thereof for the treatment of cancer

WO 2018/049214 Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer

WO 2018/152220 Pyrazolopyridine compounds and uses thereof

WO 2019/051199 6-Cyano-indazole compounds as Hematopoietic Progenitor Kinase 1

(HPKl) Modulators

US 2019/0256500 Preparation of indazolyl pyrimidines compounds and uses thereof.

US 2019/0256520 Indazole compounds and uses thereof

US 201900315717 Preparation of benzimidazole and indole compounds for inhibiting HPKl activity

WO 2019/164846 N-(Phenyl)-2-(phenyl) pyrimidine-4-carboxamide derivatives and related compounds as HPKl inhibitors for treating cancer

US 20200048141 Preparation of benzothi azole as HPKl inhibitors for the treatment and prevention of cancer W02021/026180 Solid Forms of an HPK1 inhibitor

W02020100027 2,3-Dihydro-lH-pyrrolo[3,4-C]pyridine-l-one derivatives as HPK1 inhibitors for the treatment of cancer

WO 2021050964 HPK1 antagonists and uses thereof

SUMMARY

There is provided compounds that are inhibitors of hematopoietic progenitor kinase 1 (HPK1), their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.

In one embodiment, there is provided a compound of Formula (I). wherein

X ¹ , X ² and X ³ are independently selected from CR ⁵ or N, with the provisos that when X ¹ is N, X ³ is CR ⁵ and when X ³ is N, X ¹ is CR ⁵ ;

R ¹ is cyclopropyl or C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F;

R ² is H, NH ₂ or C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F;

R ³ is selected from H, R ⁶ , OR ⁶ , NHR ⁶ , Cl, CN, CCH, NH2, SCH3, cyclopropyl, cyclobutyl,

NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH( C _1-2 alkyl)N(CH ₃ ) ₂ , oxetan-3-yl,

NH-cyclopropyl and O-cyclopropyl;

R ⁴ is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH3) ₂ R8 CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ;

R ⁵ is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _{1 - 2} alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl;

R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0( C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ )2 and (4- to 5-membered)heterocycloalkyl containing one O; R ⁷ is selected from NH-cyclopropyl, [di methyl (oxo)-λ ⁶ -sulfanylidene]ami no, (C _{1 -}

₄ alkyl)sulfonimidoyl, SO ₂ CH ₃ , OSO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ , cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH, and imidazolyl, wherein said imidazolyl is substituted by 0 or 1 R ¹¹ ;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ;

R ¹⁰ is independently selected from H and C _1-2 alkyl , wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R ¹¹ is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

The compounds of Formula (I) are inhibitors of HPK1. Thus, the compounds of Formula (I) can be used as a medicament, in particular for disorders, disease or conditions responsive to inhibition of HPK1, and more specifically cancer.

In another embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), wherein the stereochemistry is undefined, e.g. a racemate or a mixture of diastereomers.

In another embodiment there is provided a pharmaceutical formulation comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), and a pharmaceutically acceptable diluent, excipient and/or inert carrier.

In a further embodiment there is provided a pharmaceutical formulation comprising a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for use in the treatment of a condition where inhibition of HPK1 would be beneficial.

In a further embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for use in therapy, especially in the treatment of cancer in a mammal, particularly a human.

In a further embodiment there is provided the use of a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for the manufacture of a medicament for the treatment of cancer.

In still a further embodiment, administration of a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I) results in a reduction in levels of activity of HPK1 in a mammal, particularly a human.

According to another aspect there is provided a process for the preparation of compounds of Formula (I), or pharmaceutically acceptable salts of compounds of Formula (I), and the intermediates used in the preparation thereof. The compounds of Formula (I) herein exemplified have an IC50 of less than 100 nmol/L for

HPK1 in enzymatic activity assays. The compounds of Formula (I) also display promising pharmacological profiles by separating desired and undesired effects in vivo.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 shows the X-ray powder diffraction pattern for Example 8, form A: 5-

(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4 -morpholinoanilino)pyrazine-2- carboxamide.

Figure 2 shows a DSC/TGA thermogram of Example 8, form A: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide.

Figure 3 shows the X-ray powder diffraction pattern for Example 8, form F: 5-

(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4 -morpholinoanilino)pyrazine-2- carboxamide.

Figure 4 shows a DSC/TGA thermogram of Example 8, form F: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide.

Figure 5 shows the molecular structure of Example 8, form F: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide.

Figure 6 shows the X-ray powder diffraction pattern for Example 8, form G: 5-

(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4 -morpholinoanilino)pyrazine-2- carboxamide.

Figure 7 shows a DSC/TGA thermogram of Example 8, form G: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide.

Figure 8 shows the X-ray powder diffraction pattern for Example 8, form I: 5-

(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4 -morpholinoanilino)pyrazine-2- carboxamide.

Figure 9 shows a DSC/TGA thermogram of Example 8, form I: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide.

Figure 10 shows the molecular structure of Example 8, form I: 5-(Methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide. Figure 11 shows the X-ray powder diffraction pattern for Example 213, form A: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 12 shows a DSC/TGA thermogram of Example 213, form A: 5-Cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxamide.

Figure 13 shows the X-ray powder diffraction pattern for Example 213, form B: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 14 shows a DSC/TGA thermogram of Example 213, form B: 5-Cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxamide.

Figure 15 shows the X-ray powder diffraction pattern for Example 213, form C: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 16 shows a DSC/TGA thermogram of Example 213, form C: 5-Cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxamide.

Figure 17 shows the X-ray powder diffraction pattern for Example 213, form D: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 18 shows the X-ray powder diffraction pattern for Example 213, form A, HC1 salt: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 19 shows a DSC/TGA thermogram of Example 213, form A, HC1 salt: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 20 shows the X-ray powder diffraction pattern for Example 213, form B, HC1 salt: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide. Figure 21 shows a DSC/TGA thermogram of Example 213, form B, HC1 salt: 5-

Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3- methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 22 shows the X-ray powder diffraction pattern for Example 213, form A, methane sulfonic acid salt: 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxam ide.

Figure 23 shows a DSC/TGA thermogram of Example 213, form A, methane sulfonic acid salt: 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 24 shows the X-ray powder diffraction pattern for Example 213, form B, methane sulfonic acid salt: 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxam ide.

Figure 25 shows a DSC/TGA thermogram of Example 213, form B, methane sulfonic acid salt: 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

Figure 26 shows a DSC/TGA thermogram of Example 213, form C, methane sulfonic acid salt: 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide.

DETAILED DESCRIPTION

This detailed description and its specific examples, while indicating embodiments, are intended for purposes of illustration only. Therefore, there is no limitation to the illustrative embodiments described in this specification. In addition, it is to be appreciated that various features that are, for clarity reasons, described in the context of separate embodiments, also may be combined to form a single embodiment. Conversely, various features that are, for brevity reasons, described in the context of a single embodiment, also may be combined to form sub-combinations thereof.

Listed below are definitions of various terms used in the specification and claims.

It is to be understood that where in this specification a group is qualified by “defined above” the said group encompasses the first occurring and broadest definition as well as each and all of the other definitions for that group. It is to be understood that in this specification “C _1-4 ” means a carbon group having 1, 2, 3 or 4 carbon atoms.

It is to be understood that in this specification “C _1-3 ” means a carbon group having 1, 2 or 3 carbon atoms.

It is to be understood that in this specification “C _1-2 ” means a carbon group having 1 or 2 carbon atoms.

In this specification, unless stated otherwise, the term “alkyl” includes both straight and branched chain alkyl groups and may be, but is not limited to, methyl, ethyl, n- propyl, /-propyl, //-butyl, sec-butyl, /so-butyl or tert- butyl.

It is to be understood that in this specification “aryl” means an aromatic or partially aromatic group having 6 to 10 carbon atoms such as for example phenyl or naphtyl.

It is to be understood that in this specification “heteroaryl” means a mono- or bicyclic aromatic or partially aromatic ring with 5 to 10 atoms and containing one or more heteroatoms independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(5- to 6- membered)heteroaryl” means an aromatic ring with 5 to 6 atoms and containing one or more heteroatoms independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(6-membered)heteroaryl” means an aromatic ring with 6 atoms and containing one or more heteroatoms independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(6-membered)heteroaryl” means for example 2-pyridone.

It is to be understood that in this specification “(5-membered)heteroaryl” means an aromatic ring with 5 atoms and containing one or more heteroatoms independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “heterocycloalkyl” means a partially or completely saturated monocyclic, bicyclic or bridged hydrocarbon ring system with 4 to 10 atoms and wherein at least one of the ring carbon atoms is replaced with a heteroatom independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(5- to 8- membered)heterocycloalkyl” means a partially or completely saturated monocyclic, bicyclic or bridged hydrocarbon ring system containing a total of 5 or 6 ring atoms, wherein at least one of the ring carbon atoms is replaced with a heteroatom independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(5- to 6- membered)heterocycloalkyl” means a partially or completely saturated monocyclic, bicyclic or bridged hydrocarbon ring system containing a total of 5 or 6 ring atoms, wherein at least one of the ring carbon atoms is replaced with a heteroatom independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(7- membered)heterocycloalkyl” means a partially or completely saturated monocyclic, bicyclic or bridged hydrocarbon ring system containing a total of 7 ring atoms, wherein at least one of the ring carbon atoms is replaced with a heteroatom independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification “(6- membered)heterocycloalkyl” means a partially or completely saturated monocyclic, bicyclic or bridged hydrocarbon ring system containing a total of 6 ring atoms, wherein at least one of the ring carbon atoms is replaced with a heteroatom independently selected from nitrogen, oxygen or sulphur.

It is to be understood that in this specification a “heterocycloalkyl” substituent may be attached via a nitrogen atom having the appropriate valences, or via any ring carbon atom.

In this specification, unless stated otherwise, the term “pharmaceutically acceptable” is used to characterize a moiety (e.g. a salt, dosage form, or excipient) as being appropriate for use in accordance with sound medical judgment. In general, a pharmaceutically acceptable moiety has one or more benefits that outweigh any deleterious effect that the moiety may have. Deleterious effects may include, for example, excessive toxicity, irritation, allergic response, and other problems and complications.

There is provided compounds of Formula (I) wherein x1, X2, x3 and R ¹ -R ¹¹ are as defined in Formula (I). In one embodiment X1, and X3 are independently selected from CR5 or N, with the provisos that when X1 is N, X3 is CR5 and when X3 is N, X1 is CR5.

In a further embodiment X1, X2 and X3 are CR ⁵

In still a further embodiment X2 is N, X1 and X3 are CR ⁵

In still a further embodiment X1 and X2 are N, X2 is CR5.

In still a further embodiment X2 and X3 are N, X1 is CR ⁵ R ⁵ is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _{1 -}

₂ alkyl, wherein said O C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl.

In one embodiment R1 is cyclopropyl or C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by

0, l, 2 or 3 F.

In a further embodiment R1 is cyclopropyl or C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R1 is cyclopropyl or CH ₃ .

In still a further embodiment R1 is cyclopropyl.

In still a further embodiment R1 is CH ₃ .

In still a further embodiment R1 is CH ₂ F.

In still a further embodiment R1 is CHF ₂ .

In still a further embodiment R1 is CF ₃ .

In one embodiment R2 is H, NH ₂ or C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1,

2 or 3 F.

In a further embodiment R2 is NH ₂ .

In still a further embodiment R2 is C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R2 is CH ₃ .

In still a further embodiment R2 is CH ₂ F. In still a further embodiment is CHF2.

In still a further embodiment is CF3.

In still a further embodiment R2 is H.

In one embodiment R3 is selected from H, R6, OR6, NHR6, Cl, CN, CCH, NH2, SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH(C ₁ - 2alkyl)N(CH3)2, oxetan-3-yl, NH-cyclopropyl and O-cyclopropyl.

In a further embodiment R3 is selected from R6, OR6, NHR6 and cyclopropyl.

In still a further embodiment R3 is selected from R6, NHR6 and cyclopropyl. R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O.

In still a further embodiment R3 is selected from C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R3 is selected from C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R3 is CH3.

In still a further embodiment R3 is CH2F.

In still a further embodiment R3 is CHF2.

In still a further embodiment R3 is CF3.

In still a further embodiment R3 is cyclopropyl.

In still a further embodiment R3 is NHC _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R3 is NHC _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R3 is NHCH3.

In still a further embodiment R3 is HCH2F.

In still a further embodiment R3 is HCHF2. In still a further embodiment is NHCF3.

In one embodiment is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6·, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6·, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and

CH ₂ R ⁸ . R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O. R7 is selected from NH-cyclopropyl, [di methyl (oxo)-λ ⁶ -sulfanylidene]ami no, (C _{1 -}

₄ alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ , cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH, and imidazolyl, wherein said imidazolyl is substituted by 0 or 1 R ¹¹ .

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) _2. R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ;

R10 is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl. In still a further embodiment R4 is selected from aryl, wherein said aryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH2, CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH2, CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH2, CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH2, CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R8 and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ . In still a further embodiment is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from NH ₂ , CN,

OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by a substituent selected from NH ₂ , CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , OR ⁸ , OCH ₂ R ⁸ and CH ₂ R ⁸

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH ₃ and C(O)N(CH ₃ ) _2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0,

1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH ₃ and C(O)N(CH ₃ ) _2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0,

1 or 2 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH ₃ and C(O)N(CH ₃ ) _2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from

F, Cl, R ⁶ and OR ⁶ , and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH ₃ ) _2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from

F, Cl, R ⁶ and OR ⁶ .

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from CH2heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2 _·

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from CH2(5- to 8- membered)heterocycloalkyl, wherein said (5- to 8-membered)heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2 _·

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from CH ₂ (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2 _·

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ , and a substituent selected from CH ₂ (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, and OR6.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from CH ₂ (6- membered)heterocycloalkyl, wherein said (6-membered)heterocycloalkyl is substituted by 0,

1 or 2 substituents independently selected from F, Cl, R6 and OR6.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from CH ₂ (7- membered)heterocycloalkyl, wherein said (7-membered)heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH3 and C(O)N(CH3) _2.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from CH ₂ (7- membered)heterocycloalkyl, wherein said (7-membered)heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6.

In still a further embodiment R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from CH ₂ (7- membered)heterocycloalkyl, wherein said (7-membered)heterocycloalkyl is substituted by 0,

1 or 2 substituents independently selected from F, Cl, R6 and OR6. In still a further embodiment R4 is selected from heteroaryl, wherein said heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ In still a further embodiment R^ is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from

F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR ⁶ ·, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸

In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ and

CH ₂ R ⁸ .

In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R ⁸ and CH ₂ R ⁸ . In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from (5- to 8-membered)heterocycloalkyl and CH ₂ (5- to 8-membered)heterocycloalkyl.

In still a further embodiment R4 is selected from (6-membered)heteroaryl, wherein said (6- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from (6-membered)heterocycloalkyl and CH ₂ (6- membered)heterocycloalkyl . In still a further embodiment is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R , and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ ,

OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸

In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ and CH ₂ R ⁸ In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R ⁸ and CH ₂ R ⁸ .

In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from (5- to 8-membered)heterocycloalkyl and CH ₂ (5- to 8-membered)heterocycloalkyl.

In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from (6-membered)heterocycloalkyl and CH ₂ (6- membered)heterocycloalkyl.

In still a further embodiment R4 is selected from (5-membered)heteroaryl, wherein said (5- membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R7. In still a further embodiment is pyrazolyl, wherein said pyrazolyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from

R ⁷

In still a further embodiment R4 is 1H-pyrazol-4-yl, wherein said 1H-pyrazol-4-yl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R ⁷ .

In still a further embodiment R4 is 1H-pyrazol-4-yl, wherein said 1H-pyrazol-4-yl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6.

In still a further embodiment R4 is 1H-pyrazol-4-yl, wherein said 1H-pyrazol-4-yl is substituted by 0, 1 or 2 substituents independently selected from R6

In one embodiment R ⁵ is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1-2 alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl. In a further embodiment R ⁵ is H.

In still a further embodiment R ⁵ is C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and O C _1-2 alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl.

In still a further embodiment R ⁵ is C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F.

In still a further embodiment R ⁵ is CH3.

In still a further embodiment R ⁵ is CH2F.

In still a further embodiment R ⁵ is CHF2.

In still a further embodiment R ⁵ is CF3.

In one embodiment R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O( C _1-2 alkyl ) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O. In a further embodiment is C _1-4 alkyl , wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3

F and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O.

In still a further embodiment is C _1-4 alkyl , wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 substituents selected from OH, CN and N(CH3)2-

In still a further embodiment R6 is C _1-4 alkyl , wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F.

In still a further embodiment R6 is C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 F. In one embodiment R7 is selected from NH-cyclopropyl, [dim ethyl (oxo)-λ ⁶ - sulfanylidene)amino, ( C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2NHCH3, S02N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3, cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH, and imidazolyl, wherein said imidazolyl is substituted by 0 or 1 R ¹¹

In a further embodiment R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH. In still a further embodiment R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3.

In still a further embodiment R7 is selected from cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH.

In one embodiment R ⁸ is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F,

Cl, R ⁶ · and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4-methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2- In a further embodiment R ⁸ is selected from (5- to 8-membered)heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R and OR ⁶ ·, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH2OH, 4-methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2 _· In still a further embodiment R ⁸ is selected from (5- to 6-membered)heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR ⁶ ·, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4-methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2-

In still a further embodiment R ⁸ is selected from (6-membered)heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F,

Cl, R6 and OR ⁶ ·, and 0, 1 or 2 substituents independently selected from c cyclopropyl, OH, C(O)CH20H, 4-methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2 _·

In still a further embodiment R ⁸ is selected from (5-membered)heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR ⁶ ·, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH2OH, 4-methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2-

In one embodiment R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ )2, NR11(CH2)2N(CH3)2, -(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH3.

In a further embodiment R ⁹ is selected from -(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ .

In still a further embodiment R ⁹ is selected from -O(CH2)2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH3.

In one embodiment R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1- 2alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl.

In a further embodiment R ¹⁰ is H.

In still a further embodiment R ¹⁰ is independently selected from C _j. 2 alkyl, wherein said C ₁ - 2alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, H2 and OC _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl.

In still a further embodiment R ¹⁰ is independently selected from C _j. 2 alkyl, wherein said C ₁ - 2alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, and NH2. In still a further embodiment R ¹⁰ is independently selected from C _j. 2 alkyl, wherein said C ₁ - 2alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F.

In one embodiment, there is provided a compound of Formula (IA), x1, and X3 are independently selected from CR ⁵ ; R is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1- 2alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; R3 is selected from H, R6, OR6, NHR6, Cl, CN, CCH, H2, SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH( C _1-2 alkyl)N(CH3)2, oxetan-3-yl, NH-cyclopropyl and O-cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O;

R4 is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH2, CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from NH-cyclopropyl, [di methyl (oxo)-λ ⁶ -sulfanylidene]ami no, (C _{1 - 4} alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3, cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH, and imidazolyl, wherein said imidazolyl is substituted by 0 or 1 R ¹¹ ;

R ⁸ is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ )2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, H ₂ and OC _{1 - 2} alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from H, R6, OR ⁶ ·, NHR ⁶ , Cl, CN, CCH, NH ₂ , SCH ₃ , cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH( C _1-2 alkyl)N(CH ₃ )2, oxetan-3-yl,

NH-cyclopropyl and O-cyclopropyl; R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O;

R4 is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH2, CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ )2 and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ )2SO ₂ CH ₃ , S02NHCH ₃ , S02N(CH ₃ )2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ )2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ )2N(CH ₃ ) ₂ , -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ )2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ; R is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ )2 and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2 HCH3, SO2N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH; R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ )2N(CH ₃ ) ₂ , -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA),

wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H; R ³ is selected from R ⁶ ·, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from aryl, wherein said aryl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , OSO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ )2N(CH ₃ ) ₂ , -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC ₁ - 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH2, CN, OR6,

R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O;

R ⁷ is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ;

R10 is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and O C _{1- 2} alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R ⁶ ·, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl, R6 and OR6, and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2; and R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA),

wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H; R ³ is selected from R ⁶ ·, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ ·, and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl, R6 and OR6, and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2; and R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R ¹¹ is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R ⁶ , NHR ⁶ and cyclopropyl;

R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ , and 0 or 1 substituent selected from NH ₂ , CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ;

R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ )2 and (4- to 5- membered)heterocycloalkyl containing one O; R is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2NHCH3, S02N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , N R ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, H2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R ¹¹ is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA),

wherein

X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H; R ³ is selected from R ⁶ ·, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from OR ⁶ ·, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R8, C(O)R ⁸ and CH2R8; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2NHCH3, S02N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH; R ⁸ is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ )2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _{1- 2} alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein

X ¹ , X ² and X ³ are CR ⁵ ; R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R ⁸ and CH2R ⁸ ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O( C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; and R ⁸ is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from (5- to 8-membered)heterocycloalkyl and CH2(5- to 8- membered)heterocycloalkyl; and

R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IA), wherein X ¹ , X ² and X ³ are CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from R7; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; and R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3; or a pharmaceutically acceptable salt thereof.

In one embodiment, there is provided a compound of Formula (IB),

wherein

X1 and are independently selected from CR ⁵ ; is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1- 2alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl;

R ³ is selected from H, R6, OR6, NHR6, Cl, CN, CCH, H2, SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH(C _1-2 alkyl)N(CH3)2, oxetan-3-yl, NH-cyclopropyl and O-cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O;

R ⁴ is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH2, CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; R is selected from NH-cyclopropyl, [dim ethyl (oxo)-λ6-sulfanylidene]ami no, (C _{1- 4} alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ , cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH, and imidazolyl, wherein said imidazolyl is substituted by 0 or 1 R ¹¹ ;

R is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _{1- 2} alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In a further embodiment, there is provided a compound of Formula (IB),

wherein

X1 and are independently selected from CR ⁵ ;

R ⁵ is H; R3 is selected from H, R6, OR ⁶ ·, NHR ⁶ \ Cl, CN, CCH, NH2, SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH(C _1-2 alkyl)N(CH3)2, oxetan-3-yl, NH-cyclopropyl and O-cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; R4 is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from H2, CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2 HCH3, SO2 N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH; R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof. In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H;

R3 is selected from R6, NHR6 and cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from aryl or heteroaryl, wherein said aryl or heteroaryl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH2, CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R8 and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R ¹¹ is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H;

R3 is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from aryl, wherein said aryl is substituted by 0 or 1 substituent selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH ₂ CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ )2 and (4- to 5- membered)heterocycloalkyl containing one O; R is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2S02CH3, SO2NHCH3, S02N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, H2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R ¹¹ is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB),

wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H; R3 is selected from R6, NHR6 and cyclopropyl; R ⁶ · is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ ·, and 0, 1 or 2 substituents independently selected from NH2, CN, OR ⁶ ·, R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O;

R ⁷ is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ )2N(CH ₃ ) ₂ , -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ; R ⁵ is H;

R3 is selected from R6, NHR6 and cyclopropyl; R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R ⁶ ·, and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl, R6 and OR6, and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, O(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H; R3 is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from phenyl, wherein said phenyl is substituted by 0 or 1 substituent selected from F, Cl and R6, and a substituent selected from morpholinyl, wherein said morpholinyl is substituted by 0, 1 or 2 substituents independently selected from F, Cl, R6 and OR6, and 0 or 1 substituent selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0, 1 or 2 substituents independently selected from NH ₂ , CN, OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O; R7 is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH; R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ )2N(CH ₃ ) ₂ , -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R11 and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-4 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein

X * and are independently selected from CR ⁵ ; R ⁵ is H;

R3 is selected from R ⁶ , NHR ⁶ and cyclopropyl;

R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ , and 0 or 1 substituent selected from NH ₂ , CN, OR ⁶ , R ⁷ , R ⁸ , R ⁹ , OR ⁸ , OCH ₂ R ⁸ , C(O)R ⁸ , C(O)CH ₃ , C(O)NHCH ₃ , CH ₂ C(O)NHCH ₃ , C(CH ₃ ) ₂ R ⁸ , CH(CH ₃ )R ⁸ and CH ₂ R ⁸ ;

R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH ₃ ) ₂ and (4- to 5- membered)heterocycloalkyl containing one O;

R ⁷ is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO ₂ CH ₃ , NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO ₂ CH ₃ , 0SO ₂ CH ₃ , C(CH ₃ ) ₂ SO ₂ CH ₃ , SO ₂ NHCH ₃ , SO ₂ N(CH ₃ ) ₂ , morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH ₃ and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH;

R ⁸ is selected from SO ₂ CH ₃ or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R ⁶ and OR ⁶ , and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH ₂ OH, 4- methylpiperazinyl, C(O)CH ₃ and C(O)N(CH ₃ ) ₂ ; R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH ₂ ) ₂ N(CH ₃ ) ₂ , -(CH ₂ ) ₂ (5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH ₂ ) ₂ (5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH ₃ ) ₂ and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1- 2alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ; R ⁵ is H;

R3 is selected from R6, NHR6 and cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from OR6, R7, R ⁸ , R ⁹ , OR ⁸ , OCH2R , C(O)R ⁸ and CH2R ; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O;

R^ is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3, NH-cyclopropyl, [dimethyl(oxo)-λ ⁶ - sulfanylidene)amino, (C _1-4 alkyl)sulfonimidoyl, SO2CH3, OSO2CH3, C(CH3)2SO2CH3, SO2 HCH3, SO2N(CH3)2, morpholine-4-sulfonyl, 4-methylpiperazine-sulfonyl, morpholinyl, CCCH3 and cyclobutyl, wherein said cyclobutyl is substituted by 0 or 1 OH; R is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, OH, C(O)CH20H, 4- methylpiperazinyl, C(O)CH3 and C(O)N(CH3)2;

R ⁹ is selected from OR ¹⁰ , N(R ¹⁰ ) ₂ , NR ¹¹ (CH2)2N(CH ₃ )2, -(CH ₂ )2(5- to 6- membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ , -O(CH2)2(5- to 6-membered)heterocycloalkyl, wherein said (5- to 6-membered)heterocycloalkyl is substituted by 0 or 1 substituents selected from R ¹¹ and azetinyl substituted by 0 or 1 substituents selected from N(CH3)2 and C(O)CH ₃ ; R ¹⁰ is independently selected from H and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH2 and OC _1- 2alkyl wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl; and

R11 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F and 0 or 1 cyclopropyl; or a pharmaceutically acceptable salt thereof. In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ; R ⁵ is H;

R3 is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from R ⁸ and CH2R ⁸ ; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; and R ⁸ is selected from SO2CH3 or heterocycloalkyl, wherein said heterocycloalkyl is substituted by 0, 1, 2, 3 or 4 substituents independently selected from F, Cl, R6 and OR6, and 0, 1 or 2 substituents independently selected from cyclopropyl, C(O)CH3 and C(O)N(CH3)2; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and X3 are independently selected from CR ⁵ ;

R ⁵ is H;

R ³ is selected from R6, NHR6 and cyclopropyl; R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F;

R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R ⁶ ·, and 0 or 1 substituent selected from (5- to 8-membered)heterocycloalkyl and CH2(5- to 8- membered)heterocycloalkyl; and R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof In still a further embodiment, there is provided a compound of Formula (IB), wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H; R3 is selected from R6, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; R4 is selected from (5-membered)heteroaryl, wherein said (5-membered)heteroaryl is substituted by 0, 1 or 2 substituents independently selected from F, Cl and R6, and 0 or 1 substituent selected from R7; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; and R is selected from cyclopropyl, wherein said cyclopropyl is substituted by 0 or 1 substituents selected from F, CN, OH or SO2CH3; or a pharmaceutically acceptable salt thereof. In one embodiment, there is provided a compound of Formula (IC), wherein x1 and are independently selected from CR ⁵ ; R ⁵ is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, H2 and OC _1- 2alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl;

R1 is cyclopropyl or C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F;

R3 is selected from H, R6, OR6, MIR ⁶ ·, Cl, CN, CCH, NH2, SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH(C _1-2 alkyl)N(CH3)2, oxetan-3-yl,

NH-cyclopropyl and O-cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof.

In a further embodiment, there is provided a compound of Formula (IC), wherein x1 and are independently selected from CR ⁵ ;

R is independently selected from H, F, Cl and C _1-2 alkyl, wherein said C _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F, CN, NH ₂ and OC _1- 2alkyl, wherein said OC _1-2 alkyl is substituted by 0, 1, 2 or 3 substituents independently selected from F and Cl;

R1 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F;

R ³ is selected from H, R6, OR6, NHR6, Cl, CN, CCH, NH ₂ , SCH3, cyclopropyl, cyclobutyl, NH((5- to 6-membered)heteroaryl containing 1 or 2 N), NH(C _1-2 alkyl)N(CH3)2, oxetan-3-yl,

NH-cyclopropyl and O-cyclopropyl; R6 is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F, 0(C _1-2 alkyl) and 0 or 1 substituents selected from OH, CN, N(CH3)2 and (4- to 5- membered)heterocycloalkyl containing one O; or a pharmaceutically acceptable salt thereof.

In a further embodiment, there is provided a compound of Formula (IC),

wherein x1 and are independently selected from CR ⁵ ;

R ⁵ is H; R1 is C _1-3 alkyl, wherein said C _1-3 alkyl is substituted by 0, 1, 2 or 3 F;

R ³ is selected from R ⁶ ·, NHR6 and cyclopropyl; R ⁶ is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; or a pharmaceutically acceptable salt thereof.

In still a further embodiment, there is provided a compound of Formula (IC), wherein x1 and X3 are independently selected from CR ⁵ ; R ⁵ is H;

R ¹ is CH ₃ ;

R ³ is cyclopropyl; R is C _1-4 alkyl, wherein said C _1-4 alkyl is substituted by 0, 1, 2 or 3 F; or a pharmaceutically acceptable salt thereof.

One or more above embodiments may be combined to provide further specific embodiments.

In one embodiment the compound of Formula (I) is selected from: 6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazin e-2-carboxamide,

5-Methyl -6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazi ne-2-carboxamide, 5-Methoxy-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanili no)pyrazine-2-carboxamide, 5-[2-(Dimethylamino)ethoxy]-6-(l-methylbenzimidazol-4-yl)-3- (4- morpholinoanilino)pyrazine-2-carboxamide,

5-Cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholi noanilino)pyrazine-2- carboxamide,

5-Methyl -6-(3-methylimidazo[4, 5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyrazine-2- carboxamide,

5-(Methylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-morpho linoanilino)pyrazine-2- carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- (4-morpholinoanilino)pyrazine-2- carboxamide, 6-(l-Methylbenzimidazol-4-yl)-5-methylsulfanyl-3-(4-morpholi noanilino)pyrazine-2- carboxamide,

5-(Ethylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-morphol inoanilino)pyrazine-2- carboxamide,

5-(Cyclopropylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-m orpholinoanilino)pyrazine-2- carboxamide,

5-Amino-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanil ino)pyrazine-2-carboxamide,

5-[[(2R)-2-Hydroxypropyl]amino]-6-(l-methylbenzimidazol-4 -yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

5-[[(2S)-2-Hydroxypropyl]amino]-6-(l-methylbenzimidazol-4 -yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-( 2,2,2- trifluoroethylamino)pyrazine-2-carboxamide, 5-(2,2-Difluoroethylamino)-6-(l-methylbenzimidazol-4-yl)-3-( 4-morpholinoanilino)pyrazine-

2-carboxamide,

5-[2-(Dimethylamino)ethylamino]-6-(l-methylbenzimidazol-4 -yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide, 5-(2-Hydroxyethylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-m orpholinoanilino)pyrazine- 2-carboxamide,

6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-( prop-2-ynylamino)pyrazine-2- carboxamide,

6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-[ [rel-(lR,2R)-2- methylcyclopropyl]amino]pyrazine-2-carboxamide,

6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-[ [rel-(lS,2S)-2- methylcyclopropyl]amino]pyrazine-2-carboxamide,

5-(Cyanomethylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-m orpholinoanilino)pyrazine-2- carboxamide, 5-[[(2R)-2-Fluoropropyl]amino]-6-(l-methylbenzimidazol-4-yl) -3-(4- morpholinoanilino)pyrazine-2-carboxamide,

5-[[(2S)-2-Fluoropropyl]amino]-6-(l-methylbenzimidazol-4- yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-( oxetan-3- ylmethylamino)pyrazine-2-carboxamide,

5-Ethynyl-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoan ilino)pyrazine-2-carboxamide,

5-(Difluoromethyl)-6-(l-methylbenzimidazol-4-yl)-3-(4-mor pholinoanilino)pyrazine-2- carboxamide,

5-Chloro-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoani lino)pyrazine-2-carboxamide, 6-(l-Methylbenzimidazol-4-yl)-5-[(l-methylpyrazol-4-yl)amino ]-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

6-(l-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-( 2-pyridylamino)pyrazine-2- carboxamide,

6-(3-Methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoani lino)-5-(oxetan-3-yl)pyrazine-2- carboxamide,

5-Ethoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morp holinoanilino)pyrazine-2- carboxamide, 6-(3-Methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilin o)-5-(trifluoromethyl)pyrazine-

2-carboxamide,

6-(3-Methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3 -(4-morpholinoanilino)pyrazine-

2-carboxamide, 5-[(l-Methylcyclopropyl)amino]-6-(3-methylimidazo[4,5-c]pyri din-7-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

5-Cyano-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morph olinoanilino)pyrazine-2- carboxamide,

5-(Cyclopropylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)-3-(4- morpholinoanilino)pyrazine-2-carboxamide,

5-Amino-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morph olinoanilino)pyrazine-2- carboxamide,

6-(3-Methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoani lino)pyrazine-2-carboxamide, 5-Methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpho linoanilino)pyrazine-2- carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4 -morpholinoanilino)pyrazine-2- carboxamide,

5-(Difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl) -3-(4-morpholinoanilino)pyrazine-

2-carboxamide, 5-Methyl -6-(l-methylimidazo[4,5-d]pyridazin-4-yl)-3-(4-morpholinoani lino)pyrazine-2- carboxamide,

5-Methyl -6-(7-methylimidazo[4, 5-c]pyridazin-4-yl)-3-(4-morpholinoanilino)pyrazine-2- carboxamide,

5-(Methylamino)-6-(7-methylimidazo[4,5-c]pyridazin-4-yl)- 3-(4- morpholinoanilino)pyrazine-2-carboxamide,

6-(3-Ethylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-( 4-morpholinoanilino)pyrazine-2- carboxamide,

6-(3-Cyclopropylimidazo[4,5-c]pyridin-7-yl)-5-(methylamin o)-3-(4- morpholinoanilino)pyrazine-2-carboxamide, 6-[3-(Difluoromethyl)imidazo[4,5-c]pyridin-7-yl]-5-(methylam ino)-3-(4- morpholinoanilino)pyrazine-2-carboxamide, 6-(7-Chloro- 1-m ethyl -benzimidazol-4-yl)-5-(methylamino)-3-(4-morpholinoanilino)p yrazine- 2-carboxamide,

6-(7-Cyano-l-methyl-benzimidazol-4-yl)-5-(methylamino)-3- (4-morpholinoanilino)pyrazine-

2-carboxamide, 6-(3,4-Dimethylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3 -(4- morpholinoanilino)pyrazine-2-carboxamide,

3-(2-Fluoro-4-morpholino-anilino)-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(2,3-Difluoro-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(2-Fluoro-3-methyl-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-(3-Chloro-2-fluoro-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(2, 3,5-trifluoro-4-morpholino- anilino)pyrazine-2-carboxamide,

3-(2-Fluoro-5-methyl-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-(3,5-Difluoro-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(3-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(l-me thylbenzimidazol-4-yl)pyrazine-

2-carboxamide,

3-(3-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(3- methyl-4-morpholino- anilino)pyrazine-2-carboxamide,

3-(3,5-Dimethyl-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-

7-yl)py ^raz ine-2-carboxamide,

3-(3-Cyano-4-morpholino-anilino)-5-(methylamino)-6-(3-met hylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(3-Methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-m ethylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide, 3-[3-(Difluoromethyl)-4-morpholino-anilino]-5-(methylamino)- 6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- (2-methyl-4-morpholino- anilino)pyrazine-2-carboxamide, 3-(2-Methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-meth ylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(2-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [(5-methyl-6-morpholino-3- pyridyl)amino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [[5-methyl-6-[(3S)-3- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxamide , 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6-[(2S)-2- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxamide , 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[6-[ (3R)-3-methylmorpholin-4-yl]- 3-pyridyl]amino]pyrazine-2-carboxamide,

3-[(5-Cyano-6-morpholino-3-pyridyl)amino]-5-(methylamino) -6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-((4-(l,4-Oxazepan-4-yl)phenyl)amino)-6-(3-methyl-3H-imi dazo[4,5-c]pyridin-7-yl)-5- (methylamino)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [[5-methyl-6-[(3R)-3- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxamide ,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-[(lR,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxamide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(lS,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxamide,

3-[2-Fluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5- yl]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[2,3-Difluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]hepta n-5-yl]anilino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [2,3,5-trifluoro-4-[(lS,4S)-2-oxa-

5-azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxa mide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (6-oxa-3- azabicyclo[3.1.1 ]heptan-3 -yl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(8-oxa-3- azabicyclo[3.2.1]octan-3-yl)anilino]pyrazine-2-carboxamide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (2-oxa-6-azaspiro[3.3]heptan-

6-yl)anilino]pyrazine-2-carboxamide,

3-Anilino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridi n-7-yl)pyrazine-2-carboxamide,

3-[4-(Difluoromethoxy)anilino]-5-(methylamino)-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide, 5-Cyclopropyl-3-[4-(l-hydroxy-l-methyl-ethyl)anilino]-6-(3-m ethylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(4-Isopropoxyanilino)-5-(methylamino)-6-(3-methylimidaz o[4,5-c]pyridin-7-yl)pyrazine-2- carboxamide,

[4-[[3-Carbamoyl-6-(methylamino)-5-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazin-2- yl]amino]phenyl] methanesulfonate,

3-[4-(2-Methoxyethoxy)anilino]-5-(methylamino)-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-[4-[2-(Dimethylamino)ethoxy]anilino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-

7-yl)py ^raz ine-2-carboxamide, 3-[4-(2-Hydroxyethoxy)anilino]-5-(methylamino)-6-(3-methylim idazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(2- morpholinoethoxy)anilino]pyrazine-2-carboxamide,

3-(4-Aminoanilino)-5-(methylamino)-6-(l-methylbenzimidazo l-4-yl)pyrazine-2-carboxamide, 3-[4-[2-Methoxyethyl(methyl)amino]anilino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[Bis(2-methoxyethyl)amino]anilino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [(2-methyl-4- pyridyl)amino]pyrazine-2-carboxamide formate salt,

3-[(2-Methoxy-4-pyridyl)amino]-5-(methylamino)-6-(3-methy limidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide, 3-[(2-Methoxy-6-methyl-4-pyridyl)amino]-5-(methylamino)-6-(7 -methylimidazo[4,5- c]pyridazin-4-yl)pyrazine-2-carboxamide hydrochloride,

3-[(2,6-Dimethyl-4-pyridyl)amino]-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide,

5-Cyclopropyl-3-[(2,6-dimethyl-4-pyridyl)amino]-6-(3-meth ylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-[(2-Methoxy-6-methyl-4-pyridyl)amino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[2-(2-Methoxyethoxy)-6-methyl-4-pyridyl]amino]-5-(meth ylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[(2-Cyano-6-methyl-4-pyridyl)amino]-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-

7-yl)py ^raz ine-2-carboxamide,

3-[(l,5-Dimethyl-6-oxo-3-pyridyl)amino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[l-(Difluoromethyl)-6-oxo-3-pyridyl]amino]-5-(methylam ino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-3-[4-[(lR,4R)-5-methyl-2,5-diazabicyclo[2 .2.1]heptan-2-yl]anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt, 5-(Methylamino)-3-[4-(8-methyl-3,8-diazabicyclo[3.2.1]octan- 3-yl)anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[(3S,5R)-3,5-Dimethylpiperazin-l-yl]anilino]-6-(3-me thylimidazo[4,5-c]pyridin-7-yl)-5-

(trifluoromethyl)pyrazine-2-carboxamide,

3-[4-[(3S,5R)-3,5-Dimethylpiperazin-l-yl]-3,5-difluoro-an ilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-3-[4-(3-methyl-3,8-diazabicyclo[3.2.1]oct an-8-yl)anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt,

5-(Methylamino)-3-[4-[(lS,4S)-5-methyl-2,5-diazabicyclo[2 .2.1]heptan-2-yl]anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[(3S,5R)-3,5-Dimethylpiperazin-l-yl]-3,5-dimethyl-an ilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 3-[4-[2-(Dimethylamino)ethyl-methyl-amino]anilino]-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt, 3-[4-[3-(Dimethylamino)azetidin-l-yl]anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt,

3-[3-Cyano-4-[(3S,5R)-3,5-dimethylpiperazin-l-yl]anilino] -5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[2,3-Difluoro-4-[4-(4-methylpiperazin-l-yl)-l-piperidyl ]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[6-(4-Isopropylpiperazin-l-yl)-5-methyl-3-pyridyl]amin o]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[5-Methoxy-6-(4-methylpiperazin-l-yl)-3-pyridyl]amino] -5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [[5-methyl-6-[(lR,4R)-5-methyl-

2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-pyridyl]amino]pyraz ine-2-carboxamide,

3-[[5-Chloro-6-[(lR,4R)-5-methyl-2,5-diazabicyclo[2.2.1]h eptan-2-yl]-3-pyridyl]amino]-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide,

5-(Methylamino)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyr idin-3-yl)amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[(6-Ethyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino]- 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[(6-Isopropyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)ami no]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 3-[4-[(Dimethylamino)methyl]anilino]-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(pyrrolidin-l- ylmethyl)anilino]pyrazine-2-carboxamide bis-formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (morpholinomethyl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-[(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(2-oxa-6-azaspiro[3.3]heptan-

6-ylmethyl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-[rel-(lR)-l-(4- methylpiperazin- 1 -yl)ethyl]anilino]pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel-(lS)-l-(4- methylpiperazin- 1 -yl)ethyl]anilino]pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel-(lR)-l- morpholinoethyl]anilino]pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel-(lS)-l- morpholinoethyl]anilino]pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [l-methyl-l-(4- methylpiperazin-l-yl)ethyl]anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(l-methyl-l-morpholino- ethyl)anilino]pyrazine-2-carboxamide,

(R)-3-((4-((3-Fluoropyrrolidin-l-yl)methyl)phenyl)amino)- 6-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-5-(methylamino)pyrazine-2-carboxamide formate salt, 3-[4-[[(3S)-3-Fluoropyrrolidin-l-yl]methyl]anilino]-5-(methy lamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 3-[4-[(3,3-Difluoropyrrolidin-l-yl)methyl]anilino]-5-(methyl amino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide formate salt,

3-[4-[[(3S)-3,4-Dimethylpiperazin-l-yl]methyl]anilino]-5- (methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide tris-formate salt, 3-[4-[[(3R)-3,4-dimethylpiperazin-l-yl]methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[6 -(morpholinomethyl)-3- pyridyl]amino]pyrazine-2-carboxamide formate salt,

3-[2-Fluoro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5- (methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 3-[3-Chloro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 3-[2-Fluoro-4-(morpholinomethyl)anilino]-5-(methylamino)-6-( 3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide formate salt,

3-[2,3-Difluoro-4-(morpholinomethyl)anilino]-5-(methylami no)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[2-Fluoro-4-[[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5 -yl]methyl]anilino]-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide, 3-[2-Fluoro-4-[[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl ]methyl]anilino]-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide,

3-[2,3-Difluoro-4-[[(lR,4R)-2-oxa-5-azabicyclo[2.2.1]hept an-5-yl]methyl]anilino]-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide, 3-[2-Chloro-4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)anilin o]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (2- morpholinoethyl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-[2-(4-methylpiperazin-l- yl)ethyl]anilino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4 -(pyrrolidin-l- ylmethyl)anilino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4 -[(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide, 5-Methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-me thylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide,

5-(Difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl) -3-[4-[(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide, 5-(Difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4- (morpholinomethyl)anilino]pyrazine-2-carboxamide,

3-[2-Fluoro-4-(morpholinomethyl)anilino]-5-methoxy-6-(3-m ethylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-[2,3-Difluoro-4-(morpholinomethyl)anilino]-5-methoxy-6- (3-methylimidazo[4,5-c]pyridin-

7-yl)py ^raz ine-2-carboxamide, 5-Methyl -6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(3S)-4-methylmorpho lin-3- yl]anilino]pyrazine-2-carboxamide,

5-Methyl -6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(3R)-4-methylmorpho lin-3- yl]anilino]pyrazine-2-carboxamide,

5-Methyl -6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(2R)-4-methylmorpho lin-2- yl]anilino]pyrazine-2-carboxamide,

5-Methyl -6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(2S)-4-methylmorpho lin-2- yl]anilino]pyrazine-2-carboxamide, 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (4- piperidyloxy)anilino]pyrazine-2-carboxamide,

3-[4-[(l-Acetyl-4-piperidyl)oxy]anilino]-5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-

7-yl)py ^r azi ^ne -2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-[(l-methyl-4- piperidyl)oxy]anilino]pyrazine-2-carboxamide,

3-[4-[[l-(2-Hydroxyacetyl)-4-piperidyl]oxy]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l -methyl-4- piperidyl)oxy]anilino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4 -[(l-methyl-4- piperidyl)oxy]anilino]pyrazine-2-carboxamide,

3-[3, 5-Difluoro-4-[(l -methyl -4-piperi dyl)oxy]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[(l-Isopropyl-4-piperidyl)oxy]anilino]-5-(methylamin o)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide formate salt,

3-[4-[[(2S,4R)-4-Hydroxy-l -methyl -pyrrol idin-2-yl]methoxy]anilino]-5-methyl-6-(l - methylbenzimidazol-4-yl)pyrazine-2-carboxamide,

3-[4-[[(2R,4S)-4-Hydroxy-l -methyl -pyrrol idin-2-yl]methoxy]anilino]-5-methyl-6-(l - methylbenzimidazol-4-yl)pyrazine-2-carboxamide,

3-[4-[[(2R,4S)-4-Methoxy-l -methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6-(l - methylbenzimidazol-4-yl)pyrazine-2-carboxamide,

3-[4-[[(2S,4R)-4-Methoxy-l - ethyl-pyrrolidin-2-yl] ethoxy]anilino]-5- ethyl-6-(l - methylbenzimidazol-4-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [3-(4-methylpiperazin-l- yl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [3-(l-methyl-4- piperidyl)anilino]pyrazine-2-carboxamide formate salt,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(4-methylimidazol-l- yl)anilino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- ([l,2,4]triazolo[4,3-a]pyridin-6- ylamino)pyrazine-2-carboxamide, 3-[4-(l-Hydroxy-l-methyl-ethyl)anilino]-5-(methylamino)-6-(3 -methylimidazo[4,5-c]pyridin-

7-yl)py ^raz in ^e -2-carboxamide,

5-Cyclopropyl-3-[[6-(l-hydroxy-l-methyl-ethyl)-3-pyridyl] amino]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[(2-Imino-2-oxo-l,3-dihydro-2-benzothiophen-5-yl)amino] -5-methyl-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxamide, rel -(R)-3 -[4-(Ethyl sulfoni mi doyl )-3,5-di methyl -anilino]-5-methyl-6-(l -methylbenzimidazol-

4-yl)pyrazine-2-carboxamide, rel -(S)-3 -[4-(Ethyl sulfonimi doyl )-3,5-di methyl -anilino]-5-methyl-6-(l -methylbenzimidazol-

4-yl)pyrazine-2-carboxamide,

3-[(2,2-Dioxo-l,3-dihydro-2-benzothiophen-5-yl)amino]-5-( methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothi azol-5-yl)amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Cyclopropyl-3-[(l -methyl-2, 2-dioxo-3H-2, 1 -benzothi azol-5-yl)amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Methoxy-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothi azol-5-yl)amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-(l,l-Dioxo-l,4-thiazinan-4-yl)anilino]-5-(methylamin o)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[[Dimethyl(oxo)- ⁶ -sulfanylidene]amino]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[[Dimethyl(oxo)-λ ⁶ -sulfanylidene]amino]-2-fluoro-anilino]-5-(methylamino )-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-[[Dimethyl(oxo)-λ ⁶ -sulfanylidene]amino]-2,3-difluoro-anilino]-5-(methyla mino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt, 3-[4-(l,l-Dioxo-l,2-thiazolidin-2-yl)anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-(l,l-Dioxothiazinan-2-yl)anilino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-(2-Fluoro-4-methylsulfonyl-anilino)-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide, (R)-3-[4-(Ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-m ethylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide,

(S)-3-[4-(Ethylsulfonimidoyl)anilino]-5-(methylamino)-6-( 3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide, rel-(R)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide, rel-(S)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[4-(tert-Butylsulfonimidoyl)anilino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(l- methylsulfonylcyclopropyl)anilino]pyrazine-2-carboxamide,

5-Methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l- methylsulfonylcyclopropyl)anilino]pyrazine-2-carboxamide,

5-Methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(l-me thylpyrazol-4- yl)amino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [(l-tetrahydropyran-4-ylpyrazol-

4-yl)amino]pyrazine-2-carboxamide,

3-[(l-Isopropylpyrazol-4-yl)amino]-5-(methylamino)-6-(3-m ethylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

3-[[l-(l,l-Dioxothian-4-yl)pyrazol-4-yl]amino]-5-(methyla mino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [[l-(l -methyl-4- piperidyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide,

5-(Methylamino)-6-(l -m ethylbenzimidazol -4-yl)-3-[[3-methyl-l -(1 -methyl -4- piperidyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide formate salt,

3-[(l,3-Dimethylpyrazol-4-yl)amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-(Methylamino)-6-(3-m ethylimidazo[4, 5-c]pyri din-7-yl)-3-[[3-methyl-l -(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide, 3-[[l-(2,2-Difluoroethyl)-3-methyl-pyrazol-4-yl]amino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 3-[[l-(2,2-Difluoroethyl)-5-methyl-pyrazol-4-yl]amino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[l-(l-Cyano-l-methyl-ethyl)-3-methyl-pyrazol-4-yl]amin o]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 5-Cyclopropyl-3-[(l,3-dimethylpyrazol-4-yl)amino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide, 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-m ethyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-3-[[l-(2,2-difluoroethyl)-3-methyl-pyrazol- 4-yl]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

3-[[l-(l-Cyano-l-methyl-ethyl)-3-methyl-pyrazol-4-yl]amin o]-5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide, 3-[[l-(l-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5-cy clopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Cyclopropyl-3-[(l,5-dimethylpyrazol-4-yl)amino]-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[( 3-methyl-lH-pyrazol-4- yl)amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-[rel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-[rel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide, 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-m ethyl-l-[rel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 5-methyl-l-[rel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-(oxetan-3-yl)pyrazol- 4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 5-methyl-l-(oxetan-3-yl)pyrazol-

4-yl]amino]pyrazine-2-carboxamide, 5-Cyclopropyl-3-[[l-(2,2-difluoroethyl)-5-methyl-pyrazol-4-y l]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Cyclopropyl-3-[[l-(3,3-difluoropropyl)-3-methyl-pyrazol -4-yl]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Cyclopropyl-3-[[l-(3,3-difluoropropyl)-5-methyl-pyrazol -4-yl]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[( 3-methyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[( 5-methyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[3-methyl- l-(l-methyl-4-piperidyl)pyrazol-

4-yl]amino]pyrazine-2-carboxamide,

5-Cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[5-methyl- l-(l-methyl-4-piperidyl)pyrazol- 4-yl]amino]pyrazine-2-carboxamide, and pharmaceutically acceptable salts thereof.

It shall be noted that any one of these specific compounds may be disclaimed from any of the herein mentioned embodiments.

In one embodiment there is provided a process for the preparation of compounds of Formula (I) or pharmaceutically acceptable salts of compounds of Formula (I), and the intermediates used in the preparation thereof.

Another embodiment is a product obtainable by any of the processes or examples disclosed herein.

MEDICAL AND PHARMACEUTICAL USE

The compounds of Formula (I) and their pharmaceutically acceptable salts are useful because they possess pharmacological activity as inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or amelioration of abnormal cell proliferative disorders such as cancer. The compounds of Formula (I) are inhibitors of HPK1. Thus, the compounds of Formula (I) can be used as a medicament, in particular for disorders, disease or conditions responsive to inhibition of HPK1, and more specifically cancer.

In a further embodiment there is provided a pharmaceutical formulation comprising a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for use in the treatment of a condition where inhibition of HPK1 would be beneficial.

In a further embodiment there is provided a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for use in therapy, especially in the prevention or treatment of cancer in a mammal, particularly a human.

In a further embodiment there is provided the use of a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I), for the manufacture of a medicament for the treatment of cancer.

In still a further embodiment, administration of a compound of Formula (I), or a pharmaceutically acceptable salt of a compound of Formula (I) results in a reduction in levels of activity of HPK1 in a mammal, particularly a human.

For the above-mentioned therapeutic indications, the dosage administered will, of course, vary with the compound employed, the mode of administration and the treatment desired. However, in general, satisfactory results are obtained when the compounds are administered at a dosage of the solid form of between 1 mg and 2000 mg per day.

The compounds of Formula (I), and pharmaceutically acceptable derivatives thereof, may be used on their own, or in the form of appropriate pharmaceutical compositions in which the compound or derivative is in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier. Thus, another aspect concerns a pharmaceutical composition comprising a novel compound of Formula (I), or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier. Administration may be by, but is not limited to, enteral (including oral, sublingual or rectal), intranasal, inhalation, intravenous, topical or other parenteral routes. Conventional procedures for the selection and preparation of suitable pharmaceutical formulations are described in, for example, Pharmaceuticals - The Science of Dosage Form Designs , M. E. Aulton, Churchill

Livingstone, 2 ⁿ d Ed. 2002. The pharmaceutical composition preferably comprises less than 80% and more preferably less than 50% of a compound of Formula (I), or a pharmaceutically acceptable salt thereof. PHARMACOLOGICAL PROPERTIES

The compounds of Formula (I) or pharmaceutically acceptable salts thereof are believed to be useful in the prevention or treatment of disorders, disease or conditions responsive to inhibition of HPK1, and more specifically cancer.

For the avoidance of doubt, as used herein, the term “treatment” includes therapeutic and/or prophylactic treatment.

When a compound or salt described herein is administered as therapy for treating a disorder, a “therapeutically effective amount” is an amount sufficient to reduce or completely alleviate symptoms or other detrimental effects of the disorder, cure the disorder, reverse, completely stop, or slow the progress of the disorder or reduce the risk of the disorder getting worse.

The compounds described herein are thus indicated both in the therapeutic and/or prophylactic treatment of these conditions.

The compounds described herein have the advantage that they may be more efficacious, be less toxic, be more selective, be more potent, produce fewer side effects, be more easily absorbed, and/or have a better pharmacokinetic profile (e.g. higher oral bioavailability and/or lower clearance), than compounds known in the prior art.

COMBINATION THERAPY

The compounds of Formula (I), or a pharmaceutically acceptable salt thereof, may also be administered in conjunction with other compounds used for the treatment of the above conditions.

In another embodiment, there is a combination therapy wherein a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and a second active ingredient are administered concurrently, sequentially or in admixture, for the treatment of one or more of the conditions listed above. Such a combination may be used in combination with one or more further active ingredients.

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, could be used in combination with check point blockade PD-(L)1 axis or with CTLA4 in efforts to expand response rates to check point blockade. Primary or secondary resistance to check point blockade may be potential indications for a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Additional combinations may include radiation, chemotherapy, surgery, tumour targeted agents or other immune targeted agents.

When used in a combination therapy, it is contemplated that the compounds of Formula (I) or pharmaceutically acceptable salts thereof and the other active ingredients may be administered in a single composition, completely separate compositions, or a combination thereof. It also is contemplated that the active ingredients may be administered concurrently, simultaneously, sequentially, or separately. The particular composition(s) and dosing frequency(ies) of the combination therapy will depend on a variety of factors, including, for example, the route of administration, the condition being treated, the species of the patient, any potential interactions between the active ingredients when combined into a single composition, any interactions between the active ingredients when they are administered to the animal patient, and various other factors known to physicians (in the context of human patients), veterinarians (in the context of non-human patients), and others skilled in the art.

PHARMACEUTICAL COMPOSITIONS

There is provided a method of treatment of a condition where inhibition of HPK1 is required, which method comprises administration of a therapeutically effective amount of a compound of Formula (I) to a person suffering from, or susceptible to, such a condition.

The compounds of Formula (I) will normally be administered via the oral, topical, parenteral, intravenous, intramuscular, subcutaneous or in other injectable ways, buccal, rectal, vaginal, transdermal and/or nasal route and/or via inhalation, in the form of pharmaceutical preparations comprising the active ingredient or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable dosage form. Depending upon the disorder and patient to be treated and the route of administration, the compositions may be administered at varying doses. Conventional procedures for the selection and preparation of suitable pharmaceutical formulations are described in, for example, Pharmaceuticals - The

Science of Dosage Form Designs , M. E. Aulton, Churchill Livingstone, 2 ^nd Ed. 2002.

Suitable daily doses of the compounds of Formula (I) in therapeutical treatment of humans are about 0.0001-100 mg/kg body weight, preferably 0.01-10 mg/kg body weight.

Oral formulations are preferred, particularly tablets or capsules which may be formulated by methods known to those skilled in the art to provide doses of the active compound in the range of 0.007 mg to 700 mg. The optimum dosage and frequency of administration will depend on the particular condition being treated and its severity; the species of the patient; the age, sex, size and weight, diet, and general physical condition of the particular patient; brain/body weight ratio; other medication the patient may be taking; the route of administration; the formulation; and various other factors known to physicians and others skilled in the art.

According to a further aspect there is thus provided a pharmaceutical formulation comprising a compound of Formula (I), or pharmaceutically acceptable derivatives thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent and/or carrier.

The compounds of Formula (I) may be present in the pharmaceutical formulation in a concentration from 0.1 to 99.5%, such as from 0.5 to 95%, by weight of the total formulation.

The protection and deprotection of functional groups is described in Protective Groups in Organic Synthesis , 4 th Ed, T.W. Greene and P.G.M. Wuts, Wiley-Interscience (2006) and Protecting Groups , 3 ^rd Ed, P.J. Kocienski, Georg Thieme Verlag (2005).

A further embodiment encompasses pharmaceutically acceptable salts of the compounds of Formula (I).

A salt of a compound of Formula (I) may be advantageous due to one or more of its chemical or physical properties, such as stability in differing temperatures and humidities, or a desirable solubility in H2O, oil, or other solvent. In some instances, a salt may be used to aid in the isolation or purification of the compound. In some embodiments (particularly where the salt is intended for administration to an animal, e.g. a human, or is a reagent for use in making a compound or salt intended for administration to an animal), the salt is pharmaceutically acceptable.

The term “pharmaceutically acceptable” is used to characterize a moiety (e.g. a salt, dosage form, or excipient) as being appropriate for use in accordance with sound medical judgment. In general, a pharmaceutically acceptable moiety has one or more benefits that outweigh any deleterious effect that the moiety may have. Deleterious effects may include, for example, excessive toxicity, irritation, allergic response, and other problems and complications. Where the compound is sufficiently basic, pharmaceutically acceptable salts include, but are not limited to, inorganic or organic acid addition salts.

For reviews on suitable salts, see Berge et al ., ./. Pharm. Sci., 1977, 66, 1-19 or Handbook of Pharmaceutical Salts: Properties, selection and use, P.H. Stahl, P.G. Vermuth, IUPAC, Wiley-VCH, 2002.

Where an acid co-former is a solid at r.t. and there is no or only partial proton transfer between the compound of Formula (I) and such an acid co-former, a co-crystal of the co- former and compound of Formula (I) may result rather than a salt. All such co-crystal forms of the compound of Formula (I) are encompassed herein.

It is also to be understood that certain compounds of Formula (I) may exist in solvated form, e.g. hydrates, including solvates of a pharmaceutically acceptable salt of a compound of Formula (I).

In a further embodiment, certain compounds of Formula (I) may exist as racemates and racemic mixtures, single enantiomers, individual diastereomers and diastereomeric mixtures. Certain compounds of Formula (I) may also contain linkages (e.g. carbon-carbon bonds, carbon-nitrogen bonds such as amide bonds) wherein bond rotation is restricted about that particular linkage, e.g. restriction resulting from the presence of a ring bond or double bond. Stereoisomers may be separated using conventional techniques, e.g. chromatography or fractional crystallization, or the stereoisomers may be made by stereoselective synthesis.

In a further embodiment, the compounds of Formula (I) encompass any isotopically-labelled (or “radio-labelled”) derivatives of a compound of Formula (I). Such a derivative is a derivative of a compound of Formula (I) wherein one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number typically found in nature. Examples of isotopes that may be incorporated include ¾ (also written as “D” for deuterium).

In a further embodiment, the compounds of Formula (I) may be administered in the form of a prodrug which is broken down in the human or animal body to give a compound of the Formula (I).

Various forms of prodrugs are known in the art. For examples of prodrug derivatives, see: Nature Reviews Drug Discovery 2008, 7, 255 and references cited therein.

Intermediate compounds may also exist in enantiomeric forms and may be used as purified enantiomers, diastereomers, racemates or mixtures. PHARMACOLOGICAL ACTIVITY ASSAY DESCRIPTIONS

HPK1, GLK, and LCK IC50 assays: Activity of purified N-terminal GST-tagged, recombinant, human HPK1, GLK, and LCK enzymes expressed in insect cells (HPK1: amino acids 1-346, ThermoFisher Scientific, #PV6356, Carlsbad, CA; GLK: amino acids 1-380, ThermoFisher Scientific, #PV6351, Carlsbad, CA; LCK: full length, Abeam, #ab79626, Cambridge, MA) was determined in-vitro using ADP-Glo Max Assay (Promega, #V7002, Madison, WI), a luminescent ADP detection assay, by quantifying the amount of ADP produced in a kinase reaction.

The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) and is correlated with the kinase activity. Two microlitres (mΐ) of enzyme mix consisting of 10 nM HPK1, 30 nM GLK, or 2 nM LCK in lx reaction buffer (50 mM HEPES (pH7.2), 1 mM DL-Dithiothreitol (DTT), 0.005% (vol/vol) Brij35, 20 mM MgC12) was spotted into Greiner 384-well low volume plate with 0.1 pi of compound, which was dosed at 100, 31.25, 12.5, 3.19, 1, 0.32, 0.1, 0.032, 0.01 and 0.003 mM of final test concentrations and preincubated for 30 minutes at room temperature. Enzymatic reactions were initiated with 2 mΐ of peptide substrate/ ATP mix (for HPK1: 10 mM LRRKtide (RLGRDKYKTLRQIRQ-amide; Cambridge Research Biochemicals, Billingham, UK), 30 mM ATP; for GLK: 14 mM LRRKtide, 60 mM ATP; for LCK: 100 μMLCKtide (EQEDEDEPEGIY GVLE-amide; Intonation, Boston, MA), 50 mM ATP) in lx reaction buffer and incubated at room temperature for 60 minutes. 4 mΐ ADP-Glo Reagent was added to terminate the reactions and deplete the remaining ATP and incubated at room temperature for 60 minutes. Finally, 8 mΐ ADP-Glo Max Detection Reagent was added to simultaneously convert ADP to ATP and incubated at room temperature for 60 minutes. The newly synthesized ATP is converted to light using a luciferase/luciferin reaction. Luminescence was read by PHERAstar FSX plate reader (BMG LAB TECH, Cary, NC) and the data was captured by PHERAstar FSX MARS data analysis software. IC50 values were processed using GeneData Screener (GeneData AG, Basel, Switzerland).

T cell assay Materials

RPMI 1640 (Sigma R5886) Heat inactivated FBS (Gibco 10270-10

Glutamax 100X (Thermo Fisher 35050061)

HEPES 1M (Thermo Fisher 15630080)

Dulbecco’s PBS (SigmaD8537)

Multi Cyt® QBeads® Human PlexScreen (2) Plex for 1 x 384 plate (Sartorius 90602) Ultra-LEAF™ Purified anti-human CD28 Antibody (Biolegend 302933)

CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscience™ (Thermo Fisher 16- 0037-85) b-mercaptoethanol (Sigma M3148)

Propidium Iodide (Abeam ab 14083)

Pen/Strep (Sigma P0781)

Non-essential amino acids (Sigma M7145)

Sodium pyruvate (Sigma S8636)

T cell media preparation

RPMI 1640 + Heat inactivated FBS 10% + Glutamax (100X) 1% + Pen/Strep 1% + Non-essential amino acids 1% + 1M HEPES to make original media lOOmM final concentration

Sodium pyruvate 1% + 1.75ul of 14.3 M original solution b-mercaptoethanol

Method

Cryo-preserved human CD3+ T cells are recovered in warm T cell media overnight. Recovered T cells are seeded at 70000 cells per well in a 384-well Black/Clear Round Bottom Ultra-Low Attachment Spheroid Microplate (Corning 3830). Compounds in a assay ready 384-well plate (Greiner 781280) are added to the seeded T cells using a Bravo liquid handler. T cells are then left in a humidified incubator at 37°C for 1 hour. At the end of incubation, the cells are transferred to a 384-well flat bottom plate (Greiner 781090) coated with anti-CD3 antibody (5ug/mL anti-CD3 in PBS, overnight incubation at 4 °C). Anti-CD28 antibody in T cell media is also added to the cells by Bravo liquid handler at 5ug/mL or lug/mL in a donor dependent manner. T cells are then incubated in a humidified incubator at 37°C for 4 hours. Cell culture supernatant is collected using a Bravo liquid handler in a v-bottom 384 well plate (Greiner 781280) after the 4-hour incubation. IL2 is detected using a IL2 MultiCyt® QBeads® kit on an iQue Screener flow cytometer (Sartorius). Briefly, capture beads are diluted by 50x in the supplied capture bead diluent. lOul per well diluted capture beads is added to each well of a v- bottom 384 well plate (Greiner 781280) using a ThermoFisher multichannel pipette. Using a Bravo liquid handler, lOul cell culture supernatant is transferred to the v-bottom plate with diluted capture beads. The plate is then sealed in foil and incubate at room temperature on a plate shaker set to 900rpm for 1 hour. At the end of incubation, 10μL per well of the supplied detection reagent is added to the wells using a ThermoFisher multichannel pipette. The plate is then sealed in foil and incubate again at room temperature on a plate shaker set to 900rpm for 2 hours before detection by iQue Screener. iQue Screener flow cytometer uses pre-configured analysis template supplied with the IL2 MultiCyt® QBeads® kit to detect IL2 in each sample wells.

The IC50/EC50 values for the Example compounds are set forth in Table 1 herein below.

Table 1

Table 2

EXAMPLES

The following examples are non-limiting examples. The following abbreviations are employed herein:

BINAP (2, 2'-bis(diphenylphosphino)- 1,1 '-binaphthyl), also known as [l-(2- diphenylphosphanyl-l-naphthyl)-2-naphthyl]-diphenyl-phosphan e BrettPhos dicyclohexyl-[3,6-dimethoxy-2-(2,4,6-triisopropylphenyl)phen yl] phosphane BrettPhos Pd G3 [(dicyclohexyl-[3,6-dimethoxy-2-(2,4,6- triisopropylphenyl)phenyl]phosphane)-2-(2'-amino-l, 1 biphenyl)]palladium(II) methanesulfonate cataCXium A bis(l-adamantyl)-butyl-phosphane cataCXium A Pd G2 chloro[(bis(l-adamantyl)-butyl-phosphane)-2-(2-aminobiphenyl )] palladium (II) cataCXium A Pd G3 [(bis(l-adamantyl)-butyl-phosphane)-2-(2'-amino-l, 1 biphenyl)]palladium(II) methanesulfonate dba dibenzylideneacetone, also known as (lE,4E)-l,5-diphenylpenta-l,4- dien-3-one

DCE 1 ,2-dichloroethane

DCM dichloromethane DIPEA N,N-diisopropylethylamine, also known as N-ethyl-N-isopropyl- propan-2-amine

DMF N,N-dimethylformamide

DPEPhos [2-(2-diphenylphosphanylphenoxy)phenyl]-diphenyl-phosphane

DSC Differential Scanning Calorimetry HATU hexafluorophosphate azabenzotriazole tetramethyl uronium, also known as N,N,N',N'-tetramethyl-l-(3-oxidotriazolo[4,5-b]pyridin-3- ium-l-yl)methanediamine;hexafluorophosphate

DIAD diisopropyl azodi carboxyl ate, also known as isopropyl (NE)-N- isopropoxycarbonyliminocarbamate DMA N,N-dimethylacetamide DMAP N,N-dimethylaminopyridine, also known as N,N-dimethylpyridin-4- amine

DMSO dimethyl sulfoxide

Dppf l,l'-Bis(diphenylphosphino)ferrocene, also known as (Ferrocene- 1,1'- diyl)bis(diphenylphosphane)

DTBAD di-tert-butyl azodi carboxyl ate, also known as tert-butyl (NE)-N-tert- butoxycarbonyliminocarbamate

EPhos dicyclohexyl-[2-isopropoxy-6-(2,4,6- triisopropylphenyl)phenyl]phosphane EPhos Pd G4 [(dicyclohexyl-[2-isopropoxy-6-(2,4,6- triisopropylphenyl)phenyl]phosphane)-2-(2'-methylamino-l, 1 biphenyl)]palladium(II) methanesulfonate

ES electrospray

HPLC high-performance liquid chromatography IPA isopropanol, also known as propan-2-ol Ir(dFCF3ppy)2(dtbbpy) [4, 4'-bis(l,l -dimethyl ethyl)-2,2'-bipyridine-N1,N1']bis[3, 5- difl uoro-2-[5-(tri fluorom ethyl )-2-pyridinyl-A']phenyl- C]Iridium(III) hexafluorophosphate

LCMS liquid chromatography-mass spectrometry mCPBA meta-chloroperbenzoic acid, also known as 3- chlorobenzenecarboperoxoic acid

MDAP mass-directed automated purification

MHz megahertz

MTBE methyl tert-butyl ether, also known as 2-methoxy-2-m ethyl-propane m/z mass divided by charge

NMP 1 -methylpyrrolidin-2-one

NMR nuclear magnetic resonance

PCy ₃ Pd G3 [(tricyclohexylphosphane)-2-(2'-amino-l,l'-biphenyl)]palladi um(II) methanesulfonate

Pd-PEPP SI-IP ent [(di(l-adamantyl)-butylphosphine)-2-(2'-amino-l, 1 '- biphenyl)]palladium(II) methanesulfonate sC0 ₂ supercritical carbon dioxide

SFC supercritical fluid chromatography

TBAF tetrabutylammonium fluoride t-BuXPhos di-tert-butyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphane t-BuXPhos Pd G3 [(di-tert-butyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphan e)-2-(2'- amino-1,1 '-biphenyl)] palladium(II) methanesulfonate

TFA 2,2,2-trifluoroacetic acid

TGA Thermogravimetric Analyis

THF tetrahydrofuran

XantPhos (5-diphenylphosphanyl-9,9-dimethyl-xanthen-4-yl)-diphenyl- phosphane

XantPhos Pd G3 [((5-diphenylphosphanyl-9,9-dimethyl-xanthen-4-yl)-diphenyl- phosphane)-2-(2'-amino-l, 1 '-biphenyl)]palladium(II) methanesulfonate

Xphos dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphane

XPhos Pd G3 (dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphane) [2-(2'- amino-1, 1 '-biphenyl)]palladium(II) methanesulfonate The following general experimental procedures were used:

Unless otherwise noted, operations are carried out at room temperature, that is, in a range of 18 to 25 degrees Celsius.

Evaporation of organic solvent was carried out using a rotary evaporator under reduced pressure (4.5 - 30 mmHg) with a bath temperature of up to 60 degrees Celsius.

In general, the course of reactions was followed by TLC or liquid chromatography/mass spectrometry and reaction times are given for illustration only.

Yields are given for illustration only and not necessarily those which can be obtained by diligent process development. Preparations were repeated if more material was required. Microwave reactions were conducted in a Biotage Initiator or Emrys Optimizer, using Biotage microwave vials.

Silica gel chromatography was performed on Biotage Selekt, Biotage Isolera, or Teledyne ISCO Combiflash Companion automated purification instruments, using Biotage Sfar,

Biotage SNAP, Agela Claricep, RediSep Rf Gold Silica, or Buchi FlashPure columns, in sizes ranging from 5 g to 300 g as appropriate.

Reverse phase chromatography was performed on Biotage Selekt, Biotage Isolera, Teledyne ISCO Combiflash Companion, or Agela Technologies automated purification instruments, using Biotage Sfar C18 Duo, RediSep Rf C18, or RediSep Rf Gold C18 columns, in sizes ranging from 5 g to 300 g as appropriate.

MDAP purification was carried out on an Agilent 1260 Infinity II (autosampler, DAD, quaternary pump, and isocratic pumps) and Agilent 1290 Infinity II (preparative pump and fraction collector) with an Agilent InfmityLab LC/MSD. Columns and gradients are specified in the examples.

Preparative HPLC purification was carried out on a Waters FractionLynx system fitted with an Acquity QDa Mass Detector, or an instrument comprising a Waters 2545, 2767, and 2489, fitted with QDa or SQ Detector 2 ESCi mass spectrometers. Columns and gradients are specified in the examples.

Preparative and analytical SFC purification was carried out on a Sepiatec Prep SFC 100, Sepiatec Prep SFC 250, Waters Prep 100, Waters SFC Method Station X5, Waters Acquity UPC ² , Berger Multigram III, Waters Acquity UPC ² with Xevo TQ-S Micro Triple Quadrupole Mass Spectrometer, Waters Prep 80, Waters Prep 150, or Waters Prep 350. Columns and gradients specified in the examples.

Ion exchange chromatography was performed using Waters PoraPak Rxn CX cartridges.

'H NMR measurements were performed on Bruker Avance Neo 300, Bruker Avance III 300, Bruker Avance III HD 300, Bruker Avance III 400, Bruker Avance III HD 400, Jeol JNM- ECZ400S/L1, Bruker AV3HD nano 400, Bruker NEO 500, or Bruker DRK 500 spectrometers operating at 1H frequencies of 300, 300, 300, 400, 400, 400, 400, 500, and 500 MHz, respectively. The experiments were typically recorded at 27 degrees Celsius. Shifts were referenced according to IUPAC 2001 guidelines, as described in DOI:

10.1006/snmr.2002.0063. In most cases, shifts were re-referenced during data processing according to the residual ¾ chemical shift of the deuterated solvent.

UPLC-MS was carried out using one of: 1) Waters Acquity UPLC and Waters SQD mass spectrometer (column temperature 30 degrees Celsius, UV detection = 210-400 nm, mass spec = ESI with positive/negative switching) at a flow rate of 1 mL/min using a solvent gradient of 2 to 98% B over 1.5 minutes (total runtime with equilibration back to starting conditions 2 minutes), where A = 0.1% formic acid in water and B = 0.1% formic acid in acetonitrile (for acid work) or A = 0.1% ammonium hydroxide in water and B =acetonitrile (for base work). For acid analysis the column used was Waters Acquity HSS T3, 1.8 micron, 2.1 mm x 30 mm; for base analysis the column used was Waters Acquity BEH Cl 8, 1.7 micron, 2.1 mm x 30mm; or 2) Shimadzu LCMS-2020 with electrospray ionization in positive ion detection mode with 20ADXR pump, SIL-20ACXR autosampler, CTO-20AC column oven, M20A PDA detector and LCMS 2020 MS detector, using one of three conditions: a) Halo C18 column (2.0 micron, 3 mm x30 mm) in combination with a gradient (5-100% B in 1.2 minutes) of water and formic acid (0.1%) (A) and acetonitrile and formic acid (0.1%) (B) at a flow rate of 1.5 mL/min; b) Halo C18 column (2.0 micron, 3 mm x 30 mm) in combination with a gradient (5-100% B in 1.2 minutes) of water and trifluoroacetic acid (0.05%) (A) and acetonitrile and trifluoroacetic acid (0.05%) at a flow rate of 1.5 mL/min; or c) Poroshell HPH C18 column (2.7 micron, 3 mm x 50 mm) in combination with a gradient (10-95% B in 2 minutes) of aqueous 46 mM ammonium carbonate/ammonia buffer at pH 10 (A) and acetonitrile (B) at a flow rate of 1.2 mL/min.

Photoredox chemistry was carried out using a 34 W Kessil HI 50 blue LED lamp (440 nm) as light source, in a HepatoChem EvoluChem™ PhotoRedOx reaction apparatus. Optical rotation data were taken on a Jasco P-2000 polarimeter, using a 100 mm path length, 0.40 w/v% solutions of compound in DMSO, with the sodium D line (589 nm), at 25 degrees Celsius.

The X-ray diffraction analysis was performed according to standard methods, which can be found in e.g. Kitaigorodsky, A.I. (1973), Molecular Crystals and Molecules, Academic Press, New York; Bunn, C.W. (1948), Chemical Crystallography, Clarendon Press, London; or Klug, H.P. & Alexander, L.E. (1974), X-ray Diffraction Procedures, John Wiley & Sons, New York. Samples were mounted on single silicon crystal (SSC) wafer mounts and powder X-ray diffraction was recorded with a PANalytical X’Pert PRO (reflection geometry, wavelength of X-rays 1.5418 A nickel-filtered Cu radiation, Voltage 45 kV, filament emission 40 mA). Automatic variable divergence and anti scatter slits were used and the samples were rotated during measurement. Samples were scanned from 2 - 50 °2Theta or 2 - 40 °2Theta using a 0.013° step width and between 44 and 233 seconds count time using a PIXCEL detector (active length 3.35 °2Theta).

It is known in the art that an X-ray powder diffraction pattern may be obtained which has one or more measurement errors depending on measurement conditions (such as equipment, sample preparation or machine used). In particular, it is generally known that intensities in an X-ray powder diffraction pattern may fluctuate depending on measurement conditions and sample preparation. For example, persons skilled in the art of X-ray powder diffraction will realise that the relative intensities of peaks may vary according to the orientation of the sample under test and on the type and setting of the instrument used. The skilled person will also realise that the position of reflections can be affected by the precise height at which the sample sits in the diffractometer and the zero calibration of the diffractometer. The surface planarity of the sample may also have a small effect. Hence a person skilled in the art will appreciate that the diffraction pattern data presented herein is not to be construed as absolute and any crystalline form that provides a power diffraction pattern substantially identical to those disclosed herein fall within the scope of the present disclosure (for further information see Jenkins, R & Snyder, R.L. ‘Introduction to X-Ray Powder Diffractometry’ John Wiley & Sons, 1996). Generally, a measurement error of a diffraction angle in an X-ray powder diffractogram may be approximately plus or minus 0.1° 2-theta, and such a degree of a measurement error should be taken into account when considering the X-ray powder diffraction data. Furthermore, it should be understood that intensities might fluctuate depending on experimental conditions and sample preparation (e.g. preferred orientation). The following definitions have been used for the relative intensity (%): 81 - 100%, vs (very strong); 41 - 80%, str (strong); 21 - 40%, med (medium); 10 - 20%, w (weak); 1 - 9%, vw (very weak). Chemical IUPAC names were generated by BioviaDraw using OpenEye Metachem 1.5.0 software.

GENERAL INTERMEDIATES Intermediate 1 1 -Methyl -4-(4A5.5-tetramethyl-E3.2-dioxaborolan-2-vO-lH-benzordlimid azole

(a)3:Bromo _: N-methyl-2 _: nitro-aniline l-Bromo-3-fluoro-2-nitro-benzene (25.0 g, 114 mmol) was added to a solution of 33% methanamine in ethanol (114 mL, 916 mmol) at 0 °C. The resulting solution was stirred at 25 °C for 5 hours. The reaction was then concentrated. The resulting residue was dissolved in ethyl acetate and washed three times with water, dried over sodium sulfate, filtered, and concentrated to afford 3-bromo-N-methyl-2-nitro-aniline (27.3 g, quantitative) as a bright orange solid; 1HNMR (500 MHz, DICHLOROMETHANE-d2) 2.94 (3H, s), 5.51 - 5.90 (1H, m), 6.82 (1H, d), 6.99 (1H, dd), 7.23 (1H, t); m/z: (ES+), [M+H]+ = 231.1 (b)3-Bromp-Nri _. methyl-benzene l,2-diamine

Iron powder (61.3 g, 1.10 mol) was added to a solution of 3-bromo-N-methyl-2-nitro-aniline (25.4 g, 110 mmol) and ammonium chloride (58.8 g, 1.10 mol) in methanol (146 mL). The resulting suspension was stirred at 60 °C for 2 hours. The reaction mixture was then concentrated. The resulting residue was partitioned between ethyl acetate and a saturated aqueous potassium carbonate solution. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography using 0-100% ethyl acetate-hexane as eluent to afford 3 -bromo-Nl -methyl-benzene- 1,2- diamine (22 g, 100%) as a purple oil; 1H NMR (500 MHz, DICHLOROMETHANE-d2) 2.89 (3H, s), 6.62 - 6.67 (1H, d), 6.69 - 6.75 (1H, t), 6.96 (1H, d); m/z: (ES+), [M+H]+ = 200.9 (c) 4-Bromo-l -methyl-benzimidazole

3 -Bromo-Nl -methyl-benzene- 1,2-diamine (22.1 g, 110 mmol) was added to a solution of 4- toluenesulfonic acid (2.09 g, 11.0 mmol) in trimethyl orthoformate (36.5 mL, 330 mmol). The resulting suspension was stirred at 60 °C for 3 hours. The reaction was then concentrated. The resulting residue was dissolved in ethyl acetate and washed three times with 10% aqueous potassium carbonate, dried over sodium sulfate, filtered, and evaporated to afford 4-bromo-l- methyl-benzimidazole (21.6 g, 93%) as a purple solid; 1H NMR (500 MHz, DICHLOROMETHANE-d2) 3.87 (3H, s), 7.21 - 7.27 (1H, m), 7.40 - 7.46 (1H, m), 7.48 - 7.53 (1H, m), 7.95 (1H, s); m/z: (ES+), [M+H]+ = 210.9 _. (d) _.. I-MethyJ-4-(4,4,5,5-tetrarnethyl-l,3,2-dioxabprolan _: 2- l)benzimidazole

4-Bromo-l -methyl- lH-benzo[d] imidazole (5.00 g, 23.7 mmol), cataCXium A Pd G3 (1.73 g, 2.37 mmol), cataCXium A (0.849 g, 2.37 mmol), bis(pinacolato)diboron (15.0 g, 59.2 mmol), and potassium acetate (6.97 g, 71.1 mmol) were combined in a three-neck flask, which was then evacuated and backfilled three times with nitrogen. Cyclopentyl methyl ether (120 mL) was added and the reaction was stirred at 80 °C for 24 hours. The reaction was then diluted with ether (100 mL) and filtered through celite, rinsing with ether. The filtrate was concentrated to a brown solid, which was sonicated in hexanes (600 mL) for 40 minutes, then allowed to stand for 90 minutes, then filtered, rinsing sparingly with hexanes, to afford 1- methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzim idazole (4.77 g, 78%, 68% by weight) as a light gray solid; 1H MR (500 MHz, DICHLOROMETHANE-d2) 1.39 (12H, s), 3.83 (3H, s), 7.31 (1H, t), 7.53 (1H, d), 7.70 (1H, d), 7.91 (1H, s). Poor behavior by LCMS.

Intermediate 2

(1-Methylbenzimidazol-4-v)boronic acid PdCl2(dppf) (5.20 g, 7.11 mmol) was added to a suspension of potassium acetate (13.95 g, 142.1 mmol), 4-bromo-l -methyl-benzimidazole (10.00 g, 47.38 mmol), and bis(pinacolato)diboron (24.06 g, 94.76 mmol) in dioxane (400 mL). The resulting mixture was stirred at 100 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 150 mm, XBridge Prep Cl 8 OBD column, using decreasingly polar mixtures of MeCN-water as eluent, and 1% formic acid as modifier, to afford (l-methylbenzimidazol-4-yl)boronic acid (8.00 g, 96% yield) as a yellow solid. 1HNMR (300 MHz, DMSO) d 3.85 (3H, s), 7.26 (1H, t), 7.56 (1H, d), 7.68 (1H, d), 8.22 (1H, s). The B(OH)2 protons broadened to baseline m/z: (ES+), [M+H]+ = 177.1

Intermediate 3

7-Bromo-3-methyl-imidazo(4.5-c)pyridine 0.5 M Sodium methoxide in methanol (425 mL, 213 mmol) was added to a mixture of 5- bromopyridine-3, 4-diamine (10.0 g, 53.2 mmol), paraformaldehyde (1.63 g, 54.3 mmol). The resulting mixture was stirred at 25 °C for 4 hours. Sodium borohydride (2.01 g, 53.2 mmol) was added to the reaction mixture. The resulting mixture was stirred at 60 °C for 1 hour. The reaction mixture was then concentrated. The resulting residue was treated with water and extracted with EtOAc. The extract was dried over sodium sulfate, filtered and concentrated. The resulting residue was suspended in tri ethyl orthoformate (200 mL) and stirred at 145 °C for 1 hour. The reaction was then cooled to 0 °C and acidified with 4 M HC1 in dioxane (16.0 mL, 64.0 mmol). The resulting precipitate was filtered to afford a yellow solid, which was partitioned between saturated aqueous potassium carbonate and ethyl acetate and extracted twice with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to yield 7-bromo-3-methyl-imidazo[4,5-c]pyridine (9.00 g, 80%) as a yellow solid; 1HNMR (500 MHz, DMSO-d6) 3.96 (3H, s), 8.48 (1H, s), 8.51 (1H, s), 8.97 (1H, s); m/z: (ES+), [M+H]+ = 212.0 Intermediate 4

3 -Methyl -7-14 A5.5-tetram ethyl -1.3.2-dioxaborolan-2-yl )imidazor4.5-c1pyridine

A mixture of 7-bromo-3-methyl-imidazo[4,5-c]pyridine (24.00 g, 113 mmol), bis(pinacolato)diboron (35.90 g, 141.5 mmol), palladium(II) acetate (2.54 g, 11.3 mmol), cataCXium A (8.12 g, 22.6 mmol), and potassium acetate (33.30 g, 339.5 mmol) was evacuated and backfilled three times with nitrogen. 2-Methyltetrahydrofuran (700 mL) was added, and the mixture was evacuated and backfilled with nitrogen two more times. The resulting mixture was stirred at 80 °C for 16 h. The reaction was then allowed to cool to room temperature, diluted with DCM (700 mL), filtered through Celite, and concentrated. The resulting residue was used in the subsequent step without further purification.

Intermediate 5

(3-Methylimidazo(4.5-c)pyridin-7-yl iboronic acid

Dichlorobis(tricyclohexylphosphine)palladium(II) (418 mg, 0.570 mmol) was added to a suspension of 7-bromo-3-methyl-3H-imidazo[4,5-c]pyridine (600 mg, 2.83 mmol), bis(pinacolato)diboron (2.16 g, 8.49 mmol), and potassium acetate (833 mg, 8.49 mmol) in toluene (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford (3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)boronic acid (460 mg crude) as a white solid. m/z: (ES+), [M+H]+ = 178.1 Intermediate 6 2-(3-Methylimidazor4.5-clpyridin-7-vl-1362-dioxazaborocane

A suspension of 7-bromo-3-methyl-imidazo[4,5-c]pyridine (29.7 g, 140 mmol), bis(pinacolato)diboron (42.7 g, 168 mmol), Palladium(II) acetate (3.14 g, 14.0 mmol), cataCXium A (10.04 g, 28.00 mmol), and potassium acetate (41.2 g, 420.00 mmol) in 2- methyl tetrahydrofuran (879 mL) sparged with argon for 20 min. The resulting mixture was stirred at 86 °C under argon for 16 h. The reaction was then allowed to cool to room temperature, then diluted with DCM (879 mL), filtered through a pad of celite, and washed twice with DCM (100 mL each). The resulting filtrate was concentrated. The resulting solid was redissolved in 2-methyl tetrahydrofuran (281 mL) and acetonitrile (167 mL).

Diethanolamine (16.88 mL, 175.0 mmol) was added. The resulting mixture was stirred at room temperature for 16 h. Additional 2-methyl tetrahydrofuran (50 mL) and diethanolamine (6.75 mL, 70 mmol) were added. The resulting mixture was stirred at room temperature for 5 h. The reaction was then filtered and washed with MeCN to afford 2-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (30.0 g, 87% yield) as a light yellow solid. 1H NMR (500MHz, Deuterium oxide) 3.02 (4H, br t), 3.78 (4H, br t), 3.94 (3H, s), 8.32 (1H, s), 8.34 (1H, s), 8.77 (1H, s). The NH proton exchanged in D2O.

Example 1

6-(T-Methylbenzimidazol-4-vD-3-(4-morpholinoanilino)pyraz ine-2-carboxamide

(a) Meth l6 _: bromp-3 _: (4 _: mprpholinoanihno)p razme _: 2 _. -carboxylate Triethylamine (0.141 mL, 1.01 mmol) was added to a solution of methyl 3,6- dibromopyrazine-2-carboxylate (100 mg, 0.34 mmol) and 4-morpholinoaniline (60 mg, 0.34 mmol) in MeOH (10 mL) at 25 °C. The resulting mixture was stirred at 70 °C for 16 hours. The solvent was then removed under reduced pressure. The residue was purified by silica gel chromatography, using 60-70% EtOAc-petroleum ether as eluent to afford methyl 6-bromo-3- (4-morpholinoanilino)pyrazine-2-carboxylate (80 mg, 60%) as a red solid; 1HNMR (300 MHz, DMSO-d6) d 3.05 (4H, t), 3.72 (4H, t), 3.90 (3H, s), 6.92 (2H, d), 7.40 (2H, d), 8.49 (1H, s), 9.74 (1H, s); m/z: (ES+), [M+H]+ = 393.1. _. (b) _. 6-Bromp-3-(4-mprpholinpaniJino)pyrazine-2-carboxarnide 7 N Methanolic ammonia (30 mL, 210 mmol) was added to methyl 6-bromo-3-(4- morpholinoanilino)pyrazine-2-carboxylate (2.00 g, 5.09 mmol) at 25 °C. The resulting mixture was stirred at 60 °C for 2 hours. The solvent was then removed under reduced pressure to afford 6-bromo-3-(4-morpholinoanilino)pyrazine-2-carboxamide (1.80 g, 94%) as a red solid; 1H NMR (400 MHz, DMSO-d6) d 3.05 - 3.10 (4H, m), 3.70 - 3.79 (4H, m), 6.91 - 6.98 (2H, m), 7.44 - 7.49 (2H, m), 8.02 (1H, s), 8.27 (1H, s), 8.47 (1H, s), 10.99 (1H, s); m/z: (ES-), [M-H]- = 377.1

(c) _. 6:(l:Methylbenzimidazol 4-yl)-3 4-morpholinoanilino)pyrazine:2-carbpxamide l,T-Bis(di-tert-butylphosphino)ferrocene palladium dichloride (35 mg, 0.050 mmol) was added to (l-methylbenzimidazol-4-yl)boronic acid (186 mg, 1.06 mmol), 6-bromo-3-((4- morpholinophenyl)amino)pyrazine-2-carboxamide (200 mg, 0.53 mmol) and potassium carbonate (219 mg, 1.59 mmol) in 1,4-dioxane (8 mL) and water (2 mL) at 25 °C under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The solvent was removed under reduced pressure. The residue was purified by preparative HPLC, using a 5 micron, 50 mm x 150 mm XBridge Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (100 mg, 44%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) d 3.14 (4H, s), 3.79 (4H, s), 4.04 (3H, s), 7.06 (2H, s), 7.52 - 7.71 (3H, m), 7.85 (1H, d), 8.13 (1H, d), 8.24 (1H, d), 8.53 (1H, s), 9.12 (1H, s), 9.47 (1H, s), 11.25 (1H, s); m/z: (ES+) [M+H]+ = 430.3.

Example 2

5-Methyl -6-(T-methylbenzimidazol-4-vD-3-(4-morpholinoanilino)pyrazin e-2-carboxamide

(a) _. 3-Amino-6-romo 5-methyl-p razine _: 2-carboxylic _. acid

N-Bromosuccinimide (209.0 g, 1175 mmol) was added to 3-amino-5-methyl-pyrazine-2- carboxylic acid (180.0 g, 1175 mmol) in acetonitrile (1.4 L). The resulting mixture was stirred at 82 °C for 30 minutes. The reaction was then cooled to 0 °C. The resulting precipitate was isolated by filtration, washed with acetonitrile, and dried under vacuum to afford 3-amino-6- bromo-5-methyl-pyrazine-2-carboxylic acid (248 g, 91% yield) as a beige solid. 1H NMR (400 MHz, DM SO) d 2.37 (3H, s), 7.36 (2H, s), 13.08 (1H, br s). {b) _. Methyl _. 3-amino-6-bromo _: 5-methyl-pyrazine-2-carbgxylate

Sulfuric acid (6.00 mL, 113 mmol) was added to a suspension of 3-amino-6-bromo-5-methyl- pyrazine-2-carboxylic acid (9.06 g, 39.1 mmol) in MeOH (200 mL). The resulting mixture was stirred at 70 °C for 17 hours. The reaction was then concentrated. The resulting residue was taken up in water, basified with saturated aqueous sodium carbonate. The resulting precipitate was collected via filtration, washed with water, and dried under vacuum to afford methyl 3-amino-6-bromo-5-methyl-pyrazine-2-carboxylate (8.41 g, 88%) as a purple solid; 1HNMR (500 MHz, DMSO-d6) 2.45 (3H, s), 3.82 (3H, s), 7.45 (2H, br s). m/r (ES+), [M+2+H] = 248.0

(c) eth l _. 3- amino _: 5-methyl-6 _: (l-methylbenzimidazgl-4-yl) yrazine _: 2-carbgxylate MeOH (14 mL) was added to a mixture of (l-methylbenzimidazol-4-yl)boronic acid (0.499 g, 2.84 mmol), methyl 3-amino-6-bromo-5-methyl-pyrazine-2-carboxylate (0.540 g, 2.19 mmol), CsF (1.000 g, 6.58 mmol) and PdCl2(dppf) (0.161 g, 0.22 mmol). The resulting mixture was degassed and purged with nitrogen, then stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction mixture was then concentrated. The residue was purified by silica gel chromatography, using 0-9% MeOH-DCM as eluent, to afford methyl 3-amino-5- methyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxylate (0.646 g, 99%) as a brown solid; 1H NMR (500 MHz, DMSO-d6) 2.26 (3H, s), 3.80 (3H, s), 3.88 (3H, s), 7.21 (1H, dd), 7.32 (2H, s), 7.36 (1H, t), 7.64 (1H, dd), 8.20 (1H, s); m/z (ES+) [M+H]+ = 298.1.

(d)Methyl 5-rnethyl-6 (l-methylbenzimidazgl4-yl)-3-(4 _: mgrphglinganiling)pyrazine-2- carboxylate 1,4-dioxane (30 mL) was added to a mixture of methyl 3-amino-5-methyl-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxylate (1.18 g, 3.98 mmol), 4-(4- bromophenyl)morpholine (0.963 g, 3.98 mmol), BrettPhos Pd G3 (0.721 g, 0.800 mmol) and cesium carbonate (3.89 g, 11.9 mmol). The resulting mixture was degassed and purged with nitrogen three times, then stirred at 100 °C for 7 hours. The reaction mixture was then treated with water and the resulting precipitate was filtered, washed with water, and dried under vacuum. The resulting solid was purified by silica gel chromatography four times, once using 0-5% MeOH-DCM as eluent and subsequent times using 0-3% MeOH-DCM as eluent, to afford methyl 5-methyl-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilin o)pyrazine-2- carboxylate (0.912 g, 50%) as an orange solid; 1H NMR (500 MHz, DMSO-d6) 2.32 (3H, s), 3.05 - 3.11 (4H, m), 3.71 - 3.77 (4H, m), 3.87 (3H, s), 3.89 (3H, s), 6.94 - 6.99 (2H, m), 7.27 (1H, dd), 7.39 (1H, t), 7.58 - 7.62 (2H, m), 7.66 (1H, dd), 8.21 (1H, s), 9.86 (1H, s); m/z (ES+) [M+H]+ = 459.3.

(e) 5-Metnyl-6-( l-metnylbenzimidazol-4-yl)-5-(4-morpholinoamlino)pyrazine-2- carppxamicle 7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (0.538 g, 1.17 mmol). The resulting mixture was stirred at 40 °C for 16 hours. Additional 7 N methanolic ammonia (10 mL, 70 mmol) was added, and the reaction mixture was stirred at 40 °C for 5 hours. The reaction was then filtered and washed with MeOH. The resulting solid was purified by silica gel chromatography, using 0-5% MeOH-DCM as eluent, to afford a yellow solid. This material was purified further by reverse phase chromatography, Cl 8, using 10- 60% MeCN-H2O as eluent and 0.2% ammonium hydroxide as modifier, to afford 5-methyl-6- (l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (0.438 g, 84%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.35 (3H, s), 3.03 - 3.10 (4H, m), 3.71 - 3.77 (4H, m), 3.88 (3H, s), 6.96 (2H, d), 7.36 - 7.41 (2H, m), 7.61 (2H, d), 7.63 - 7.67 (1H, m), 7.81 (1H, br d), 8.02 (1H, br d), 8.22 (1H, s), 11.01 (1H, s); m/z: (ES+) [M+H]+ = 444.2.

Example 3

(a) eth l _. 3:amino:6-chloro-5:methox -pyrazine-2-carbox late Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate (10 g, 45 mmol) and potassium carbonate (18.7 g, 135 mmol) were suspended in MeOH (175 mL). The resulting suspension was stirred at 25 °C for 16 hours. The solvent was removed under reduced pressure and the resulting residue was suspended in water (400 mL). The resulting suspension was stirred vigorously at 25 °C for 2 hours. The suspension was filtered and the filter cake was dried under vacuum to afford methyl 3-amino-6-chloro-5-methoxy-pyrazine-2-carboxylate (6.9 g, 70%) as a beige solid; 1H NMR (500 MHz, DMSO-d6) 3.79 (3H, s), 3.96 (3H, s), 7.60 (2H, br s); m/z: (ES+), [M+H]+ = 218.1

(b)Methyl _. 6-chloro-3:fluoro-5-methox -pyrazine-2-carboxylate

Sodium nitrite (2.3 g, 33 mmol) was added portion-wise to a stirred suspension of methyl 3- amino-6-chloro-5-methoxy-pyrazine-2-carboxylate (6.90 g, 31.7 mmol) in HF-pyridine (20 mL, 580 mmol) at -10 °C. The resulting suspension was stirred at 25 °C for 1 hour. The reaction was then diluted with DCM (50 mL) and quenched with water (200 mL). The layers were separated and the aqueous layer was extracted twice with DCM (20 mL each). The combined organics were dried over magnesium sulfate, filtered, and concentrated to afford methyl 6-chloro-3-fluoro-5-methoxy-pyrazine-2-carboxylate (6.80 g, 97%) as a peach solid; 1HNMR (500 MHz, DMSO-d6) 3.87 (3H, s), 4.06 (3H, s); m/z: (ES+), [M+H]+ = 221.1. .(c) _. Meth l 6-chloro-5-methqxy-3-(4 _: morphplinoanilinp)pyrazine-2-carboxyJate DIPEA (6 mL, 34.35 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5-methoxy- pyrazine-2-carboxylate (6.80 g, 30.8 mmol) and 4-morpholinoaniline (5.77 g, 32.4 mmol) in DMF (18 mL). The resulting solution was stirred at 100 °C for 15 minutes. The reaction was then removed from heat and allowed to cool to room temperature. The reaction was filtered, rinsing sparingly with EtOAc, to afford methyl 6-chloro-5-methoxy-3-(4- morpholinoanilino)pyrazine-2-carboxylate (9.28 g, 79%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.93 - 3.13 (4H, m), 3.61 - 3.78 (4H, m), 3.86 (3H, s), 3.98 (3H, s), 6.95 (2H, d), 7.50 (2H, d), 10.01 (1H, s); m/z: (ES+), [M+H]+ = 379.5.

(d) _. MethyL5-methoxy-6- l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino) _. pyrazine-2- carboxylate

The reaction was run in quintuplicate to fit in microwave vials. In each vial, methyl 6-chloro- 5-methoxy-3-(4-morpholinoanilino)pyrazine-2-carboxylate (1.73 g, 4.57 mmol), l-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzimidazole (2.43 g, 63 wt%, 5.94 mmol), Pd(dppf)Cl2 (0.400 g, 0.490 mmol), and cesium fluoride (2.08 g, 13.7 mmol) were combined and purged under nitrogen. MeOH (15 mL) was added to each and each reaction was stirred at 100 °C for 3 hours in a Biotage microwave reactor. The reaction vials were then combined, concentrated, loaded onto Celite, and purified via silica gel chromatography using 0-10% methanol-DCM as eluent and 0-1% ammonia as modifier, to afford an orange solid. Methanol (30 mL) was added to the solid and the resulting suspension was stirred at 40 °C for 1 hour, then allowed to stand at 25 °C for 30 minutes. The suspension was filtered, rinsing sparingly with methanol, to afford methyl 5-methoxy-6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxylate (9.99 g, 92%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 3.05 - 3.11 (4H, m), 3.69 - 3.75 (4H, m), 3.84 (3H, s), 3.84 (3H, s), 3.86 (3H, s), 6.98 (2H, d), 7.18 - 7.29 (1H, m), 7.33 (1H, t), 7.55 - 7.71 (3H, m), 8.13 (1H, s),

10.16 (1H, s); m/z: (ES+), [M+H]+ = 475.4

_. (e) _. 5-Methoxy-6 _: (l _: methylbenzimidazgl-4-yl) 3-(4-mgrphglinoaniling)pyrazine-2- carboxamide

The reaction was run in quintuplicate to fit in microwave vials. In each vial, methyl 5- methoxy-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino )pyrazine-2-carboxylate (2.00 g, 4.22 mmol) was suspended in 7 N methanolic ammonia (20 mL, 140 mmol). Each reaction was stirred at 100 °C for 8 hours in a Biotage microwave reactor. The reaction vials were allowed to cool, then combined, filtered, and rinsed sparingly with MeOH to afford 8.0 g of a yellow solid. This material was combined with 3.64 g of another batch of the same material, which was then loaded onto celite and purified by silica gel chromatography, using 0-5% MeOH-DCM as eluent and 0-0.5% ammonia as modifier, to afford a yellow solid. Methanol (70 mL) was added and the resulting suspension was stirred at 40 °C for 1 hour, then allowed to stand at 25 °C for 1 hour. The suspension was filtered and dried under vacuum to afford 5-methoxy-6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (9.77 g, 84 %) as a yellow solid; 1H NMR (600 MHz, DMSO-d6) 3.03 - 3.12 (4H, m), 3.68 - 3.76 (4H, m), 3.86 (3H, s), 3.89 (3H, s), 6.92 - 7.01 (2H, m), 7.33 (1H, t), 7.45 (1H, dd), 7.56 - 7.62 (3H, m), 7.64 (1H, d), 7.85 (1H, d), 8.16 (1H, s), 11.18 (1H, s); m/z: (ES+), [M+H]+ = 460.4

Example 4

5-(2-(Dimethylamino)ethoxy]-6-(l-methylbenzimidazol-4-yl) -3-(4- morpholinoanilino)pyrazine-2-carboxamide

.(a) Methyl3-amino-6-chloro-5-( 2-(d

Sodium (0.311 g, 13.5 mmol) was added to methyl 3-amino-5,6-dichloro-pyrazine-2- carboxylate (3.00 g, 13.5 mmol), and 2-(dimethylamino)ethanol (5.00 mL, 13.5 mmol). The resulting mixture was stirred at 25 °C for 3 hours. The solvent was then removed under reduced pressure. The residue was purified by silica chromatography, using 0-20% MeOH- DCM as eluent, to afford methyl 3-amino-6-chloro-5-[2-(dimethylamino)ethoxy]pyrazine-2- carboxylate (1.50 g, 40%) as a yellow gum. 1H NMR (300 MHz, DMSO-d6) 5 2.21 (6H, s), 2.65 (2H, t), 3.79 (3H, s), 4.44 (2H, t), 7.59 (2H, s); m/z: (ES+), [M+H]+ = 275.0.

.(bJ.Methyl .3-amino-5-£2-(d£methylammo)ethoxy)-6 carboxylate

1,4-dioxane (10 mL) was added to a mixture of (l-methylbenzimidazol-4-yl)boronic acid (480 mg, 2.73 mmol), methyl 3-amino-6-chloro-5-[2-(dimethylamino)ethoxy]pyrazine-2- carboxylate (500 mg, 1.82 mmol), CsF (829 mg, 5.46 mmol), and PdC12(dppf)-DCM adduct (223 mg, 0.27 mmol). The resulting mixture was stirred at 100 °C for 2 hours. The solvent was then removed under reduced pressure. The residue was purified by Cl 8 reverse phase chromatography, using 0-50% MeCN-H2O as eluent, and 10 mM ammonium bicarbonate as modifier, to afford methyl 3-amino-5-[2-(dimethylamino)ethoxy]-6-(l-methylbenzimidazol- 4- yl)pyrazine-2-carboxylate (180 mg, 27%) as a yellow gum; 1H NMR (300 MHz, DMSO-d6) d 2.04 (6H, s), 2.40 - 2.5 (2H, m), 3.78 (3H, s), 3.87 (3H, s), 4.25 - 4.40 (2H, m), 7.21 (1H, d), 7.32 (1H, t), 7.50 (2H, s), 7.60 (1H, d), 8.14 (1H, s); m/z\ (ES+), [M+H]+ = 371.3.

{c) _. 5:^2:(Dimethylamino)ethpxyJ:6-(l-methylbenzimidazol-4- yl)-3-(4-

_. 01orph _.Q. liUQanilinp)pyrazine-2-carboxyJic acid

1,4-Dioxane (18 mL) was added to a mixture of methyl 3-amino-5-[2-

(dimethylamino)ethoxy]-6-(l-methylbenzimidazol-4-yl)pyraz ine-2-carboxylate (170 mg, 0.46 mmol), 4-(4-bromophenyl)morpholine (220 mg, 0.92 mmol), BrettPhos Pd G3 (62 mg, 0.070 mmol), and cesium carbonate (449 mg, 1.38 mmol). The resulting mixture was stirred at 25 °C for 8 hours. The solvent was removed under reduced pressure. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-50% MeCN-FbO as eluent, to afford 5-[2-(dimethylamino)ethoxy]-6-(l-methylbenzimidazol-4-yl)-3- (4- morpholinoanilino)pyrazine-2-carboxylic acid (80 mg, 34%) as a yellow gum; 1H NMR (300 MHz, DMSO-d6) d 2.39 (6H, s), 2.81 - 2.96 (2H, m), 3.04 - 3.12 (4H, m), 3.69 - 3.79 (4H, m), 3.89 (3H, s), 4.49 - 4.61 (2H, m), 6.96 (2H, d), 7.39 (2H, s), 7.51 - 7.72 (3H, m), 8.34 (1H, s); NH and COOH signals were broadened to the baseline; m/z\ (ES+) [M+H]+ = 518.4. {dJ _.. 5^[2rXDimethylamino)ethoxy]-6-Q-methylbenzimidazol-4-y l)-3 _: (4 _: moiphplino^iHnp)pyrazine-2-carboxamide

Triethylamine (0.061 mL, 0.43 mmol) was added to a suspension of 5-[2- (dimethylamino)ethoxy]-6-(l-methylbenzimidazol-4-yl)-3-(4-mo rpholinoanilino)pyrazine-2- carboxylic acid (75 mg, 0.14 mmol), ammonium chloride (47 mg, 0.87 mmol), and HATU (72 mg, 0.19 mmol) in DMF (5 mL). The resulting mixture was stirred at 25 °C for 2 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by reverse phase chromatography on cl 8, using 0-100% MeCN-H?0 as eluent and 10 mmol/L ammonium bicarbonate as modifier, to afford 5-[2-(dimethylamino)ethoxy]-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxamide (28.0 mg, 37%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.13 (6H, s), 3.08 (4H, t), 3.30 (2H, s), 3.71 - 3.78 (4H, m), 3.87 (3H, s), 4.44 (2H, s), 6.97 (2H, d), 7.34 (1H, t), 7.54 (2H, d), 7.57 - 7.62 (2H, m), 7.67 (1H, s), 7.88 (1H, s), 8.21 (1H, s), 11.14 (1H, s); m/z\ (ES+), [M+H]+ = 517.6.

Example 5 5-Cvclopropyl-6-(T-methylbenzimidazol-4-vO-3-(4-morpholinoan ilino)pyrazine-2- carboxamide

(a) Methyl 3 -amino-6-chl orp- 5 _: cy clqpropy 1 -py ;razine-2-cagrb oxy 1 ate Potassium cyclopropyltrifluoroborate (0.800 g, 5.40 mmol) was added to a suspension of methyl 3-amino-5,6-dichloro-pyrazine-2-carboxylate (1.00 g, 4.50 mmol), palladium(II) acetate (0.15 g, 0.68 mmol), cataCXium A (0.484 g, 1.35 mmol) and cesium carbonate (2.93 g, 9.01 mmol) in water (1.5 mL) and toluene (15 mL). The resulting mixture was stirred at 100 °C for 10 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by silica gel chromatography, using 0-30% EtOAc-pentane as eluent, to afford methyl 3-amino-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate (0.65 g, 63%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.02 (2H, d), 1.11 (2H, dt), 2.36 (1H, tt),

3.77 (3H, s), 7.35 (2H, s). m/r (ES+), [M+H]+ = 227.90

{¾ _. Methyl _. 3-aming-5-cj _. cj _. opropyl _: 6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxylate (l-Methylbenzimidazol-4-yl)boronic acid (580 mg, 3.3 mmol) was added to a suspension of methyl 3-amino-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate (625 mg, 2.75 mmol), PdCh(dppf) (402 mg, 0.550 mmol) and CsF (1.25 g, 8.24 mmol) in 1,4-dioxane (10 mL). The resulting mixture was stirred at 100 °C for 14 hours. The reaction mixture was then filtered through celite and the solvent was removed under reduced pressure. The resulting residue was purified by reverse phase chromatography on cl 8, using 0-30% MeCN-H?0 as eluent and 0.1% formic acid as modifier, to afford methyl 3-amino-5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxylate (405 mg, 46%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 0.81 (2H, dt), 0.98 (2H, q), 1.78 (1H, tt), 3.79 (3H, s), 3.91 (3H, s), 7.25 (2H, s), 7.38 (1H, t), 7.65 (1H, dd), 8.19 (2H, s). m/r (ES+), [M+H]+ = 324.2. {?) Methyl _. 5:Cyclgpropyl-6:(l _: methylbenzimidazol-4-yl)-3-(4-morpholinoaniling)pyrazi ne-2- carboxyl _. ate

4-(4-Bromophenyl)morpholine (313 mg, 1.29 mmol) was added to a suspension of methyl 3- amino-5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2- carboxylate (380 mg, 1.18 mmol), cesium carbonate (766 mg, 2.35 mmol) and Brettphos Pd G3 (107 mg, 0.120 mmol) in 1,4-dioxane (4 mL). The resulting mixture was stirred at 100 °C for 12 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (130 mg, 23%) as an orange solid; 1H NMR (300 MHz, DMSO-d6) d 0.76 - 0.94 (4H, m), 1.83 - 1.95 (1H, m), 3.09 - 3.11 (4H, m), 3.71 - 3.80 (4H, m), 3.80 (3H, s), 3.87 (3H, s), 6.95 - 7.01 (2H, m), 7.25 (1H, d), 7.27 - 7.31 (1H, m), 7.40 (2H, q), 7.51 - 7.56 (2H, m), 9.90 (1H, s); m/z\ (ES+), [M+H]+ = 485.2 {¾.5rCydpprgpyl-6-(l _: methylbenzimidazol-4-yl) _: 3-(4 _: morpholinoanilino)pyrazine-2- carboxamide

7 N Methanolic ammonia (6.0 mL, 42 mmol) was added to methyl 5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (110 mg, 0.23 mmol). The resulting suspension was stirred at 70 °C for 3 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by preparative HPLC Column, using a SunFire C18 OBD 5 pm, 19 mm X 250 mm as the column, 19%-33% MeCN/HiO as eluent and 0.05% trifluoroacetic acid as modifier, to afford 5-cyclopropyl-6- (l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (35 mg, 33%) as an orange solid; 1HNMR (400 MHz, DMSO-d6) d 1.00 (2H, dt), 1.13 (2H, dt), 1.98 (1H, dq), 3.04 - 3.19 (4H, m), 3.72 - 3.80 (4H, m), 4.09 (3H, s) 6.94 - 7.02 (2H, m), 7.51 - 7.57 (2H, m), 7.66 - 7.79 (2H, m), 7.88 (1H, s), 7.95 - 8.05 (2H, m), 9.41 (1H, br s), 11.15 (1H, s); m/z: (ES+), [M+H]+ = 470.2.

Example 6

5-Methyl -6-(3-methylimidazor4.5-clpyridin-7-vO-3-(4-morpholinoanilin o)pyrazine-2- carboxamide £aj. Methyl. J.:.ami_no:_5_-methyJ_-6 _: _(3-m_ethyJ_i_mi_dazo[_4,5-cJpyridin_-7:y]J.p.yrazin_e -2-carb_o_xyJ_ate PdCb(dppf) (370 mg, 0.51 mmol) was added a suspension of CsF (773 mg, 5.09 mmol), methyl 3-amino-6-chloro-5-methyl-pyrazine-2-carboxylate (513 mg, 2.54 mmol) and (3- methylimidazo[4,5-c]pyridin-7-yl)boronic acid (450 mg, 2.54 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-amino-5-methyl-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (300 mg, 40% yield) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.30 (3H, s), 3.82 (3H, s), 4.00 (3H, s), 7.41 (2H, s), 8.37 (1H, s), 8.43 (1H, s), 9.06 (1H, s); m/z\ (ES+), [M+H]+ = 299.1 _. (bJ _. Methy! _. 5 _.-. !IiethyL- _. 6 _T (3-methyJirnidazo[4,5-c]pyridin-7 _T yl) _T 3-(4- Plorphplinpanilinp)pyrazine-2-carboxylate

Methyl 3-amino-5-methyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxylate (280 mg, 0.94 mmol) was added to a suspension of 4-(4-bromophenyl)morpholine (227 mg, 0.940 mmol), cesium carbonate (612 mg, 1.88 mmol) and Brettphos Pd G3 (170 mg, 0.19 mmol) in 1,4-dioxane (15 mL). The resulting mixture was stirred at 100 °C for 16 hours. The solvent was removed under reduced pressure. The resulting residue was purified by silica gel chromatography, using 0-40% MeOH-DCM as eluent, to afford methyl 5-methyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxylate (200 mg, 46%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.37 (3H, s), 3.10 (4H, t), 3.75 (4H, s), 3.90 (3H, s), 4.01 (3H, s), 6.98 (2H, d), 7.61 (2H, d), 8.40 (1H, s), 8.45 (1H, s), 9.06 (1H, s), 9.90 (1H, s); m/z\ (ES+), [M+2H] ²⁺ = 230.7.

{c).5-Methyl-6 _: (3 _: methyHmidazg[4 _^ 5 _: c]pyridin-7:ylJ:3-(4-morpholinoanilinoJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-methyl-6-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-3-((4-morpholinophenyl)amino)pyr azine-2-carboxylate (190 mg, 0.41 mmol). The resulting suspension was stirred at 80 °C for 1 hours. The solvent was then removed under reduced pressure. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 x 150 mm, Sunfire prep C18 column, 10 to 28% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5-methyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)- 3-(4-morpholinoanilino)pyrazine-2-carboxamide (26 mg, 14%) as a yellow solid; lH NMR (300 MHz, DMSO-d6) d 2.38 (3H, s), 3.02 - 3.11 (4H, m), 3.69 - 3.78 (4H, m), 3.99 (3H, s), 11.05 (1H, s). (ES+) [M+H]+ = 445.2.

Example 7 5-(Methylamino)-6-(T-methylbenzimidazol-4-vO-3-(4-morpholino anilino)pyrazine-2- carboxamide

£a) _.. MethyJ _. J _. :Aniino:6-chl_oro _. -5:_(methyJ_am_i_noJpyraz_i_ne^2 _: _carboxyJate 2 M Methylamine in THF/MeOH (99 mL, 198.00 mmol) was added to methyl 3-amino-5,6- dichloropyrazine-2-carboxylate (11.0 g, 49.5 mmol). The resulting suspension was stirred at 25 °C for 30 minutes. It was then concentrated to half its original volume, diluted with water (200 mL), filtered, and rinsed with water. The filter cake was dried under vacuum to afford methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (9.88 g, 92%) as a pale yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.85 (3H, d), 3.72 (3H, s), 7.25 (2H, br s), 7.53 (1H, br d). m/z: (ES+), [M+H]+ = 217.1

{¾ _. Methyl _. 6-cMoro-3:fluoro-5:(methylamino)pyrazine-2:carboxylate Sodium nitrite (3.30 g, 47.89 mmol) was added portionwise to a suspension of methyl 3- amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (9.88 g, 45.6 mmol) in HF-pyridine (20 mL, 580 mmol) at -10 °C. The reaction was stirred at 25 °C for 1 hour. The reaction was then quenched with DCM (50 mL) and water (100 mL). The layers were separated and the aqueous layer was extracted three times with DCM (50 mL each). The combined organic layers were washed with saturated aqueous ammonium chloride (50 mL). The combined aqueous layers were extracted a final time with DCM (50 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford methyl 6-chloro-3- fluoro-5-(methylamino)pyrazine-2-carboxylate (9.50 g, 95%) as a peach-colored solid; 1H NMR (500 MHz, DMSO-d6) 2.88 (3H, d), 3.78 (3H, s), 8.34 (1H, br d); m/z: (ES+), [M+H]+ 220.1 {c)M?thyJ _.. 6 _: chlprg-5-(methylamino) _: 3-(4-mo^)holinoanilino)pyrazine-2 _: carbpxylate DIPEA (10.0 mL, 57.3 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5- (methylamino)pyrazine-2-carboxylate (8.53 g, 38.8 mmol) and 4-morpholinoaniline (7.3 g, 41 mmol) in DMF (30 mL). The reaction was stirred at 100 °C for 90 minutes. The reaction was then cooled to room temperature and quenched with water (300 mL). The resulting suspension was filtered, and the filter cake was dried under vacuum to afford methyl 6-chloro- 5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2-carboxylat e (9.48 g, 65%) as a yellow- brown solid; 1HNMR (500 MHz, DMSO-d6) 2.90 (3H, d), 3.01 - 3.09 (4H, m), 3.70 - 3.75 (4H, m), 3.79 (3H, s), 6.92 (2H, br d), 7.54 (2H, d), 7.82 (1H, br d), 10.08 (1H, s); m/z: (ES-), [M-H]- = 376.4

{dJ _. Methyl _. 5-(methylamino)-6-(l _: methylbenzimidazol-4-yl) _: 3-(4-

Plprphglinoaniling)pyrazine-2-carboxyJate

Methyl 6-chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (1.50 g, 3.97 mmol), l-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benz imidazole (1.63 g, 69 wt%, 4.37 mmol), Pd(dppf)Ch (0.29 g, 0.40 mmol), and cesium fluoride (1.81 g, 11.9 mmol) were combined in a microwave vial, which was then evacuated and backfilled three times with nitrogen. MeOH (15 mL) was added and the reaction was stirred at 100 °C for 8 hours in a Biotage microwave reactor. The reaction was then concentrated, loaded onto Celite, and purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford a yellow-brown solid. This material was suspended in MeOH (40 mL), stirred at 40 °C for 30 minutes, and left to stand for 1 hour. The resulting suspension was then filtered and rinsed sparingly with MeOH to afford methyl 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (1.49 g, 79%) as a dark yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.90 (3H, d), 3.04 - 3.10 (4H, m), 3.68 - 3.78 (4H, m), 3.80 (3H, s), 3.90 (3H, s), 6.95 (2H, d), 7.36 - 7.44 (1H, m), 7.44 - 7.51 (1H, m), 7.58 - 7.74 (3H, m), 8.04 (1H, br d), 8.30 (1H, s), 10.23 (1H, s); m/z: (ES+), [M+H]+ = 474.4

{e) _. 5:{Methylaming)-6-( 1 -methylbenzimidazgl-4 _: yl) _: 3 -(4-morphplinoaniling)pyrazine-2: carboxylic _aci d bi s-trifluprgacetate salt

Lithium hydroxide monohydrate (2.64 g, 63.0 mmol) was added to a suspension of methyl 5- (methylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoa nilino)pyrazine-2- carboxylate (2.98 g, 6.30 mmol) in water (16 mL) and MeOH (16 mL). The resulting mixture was stirred at 100 °C for 90 minutes in a Biotage microwave reactor. The reaction was allowed to cool to room temperature, diluted with water (70 mL), and concentrated to a volume of 40 mL, then filtered and rinsed with water. The resulting yellow filter cake was purified by reverse phase chromatography, using 0-50% MeCN/FbO as eluent and 0.1% TFA as modifier, to afford 5-(methylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxylic acid (3.00 g, 70%) as an orange solid and presumed bis-trifluoroacetate salt; 1HNMR (500 MHz, DMSO-d6) 2.87 (3H, br s), 3.04 - 3.11 (4H, m), 3.13 - 3.17 (3H, m), 3.62 - 3.86 (4H, m), 4.06 (3H, br s), 6.86 - 7.10 (2H, m), 7.12 - 7.46 (1H, m), 7.53 - 7.77 (4H, m), 7.94 (1H, br d), 8.98 - 9.57 (1H, m), 10.50 (1H, br s), 12.09 (1H, br s); m/z: (ES+), [M+H]+ = 460.3

(t) 3-(Metnylamino)-6-( l-metnylbenzimidazol-4-yl)-5-(4-morpholinoamlino) _. pyrazine:2- carboxamide

DIPEA (7.00 mL, 40.1 mmol) was added to a suspension of 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylic acid, ditrifluoroacetate (5.52 g, 8.05 mmol), ammonium chloride (5.16 g, 96.6 mmol), and HATU (4.59 g, 12.1 mmol) in DMF (60 mL). The resulting mixture was stirred at 25 °C for 3 hours. The reaction was then diluted with saturated aqueous sodium bicarbonate (60 mL) and water (200 mL). The resulting yellow suspension was stirred at 25 °C for 30 min and was then filtered and rinsed with water. The bright yellow filtercake was dried under vacuum for 20 h to afford a yellow solid. This material was suspended in MeOH (70 mL), stirred at 40 °C for 2 hours, sonicated for 1 hour, and allowed to stand for 3 hours. The resulting suspension was filtered, rinsed sparingly with MeOH, and dried under vacuum to afford 5-(methylamino)-6- (l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (3.54 g, 96%) as a yellow solid; 1H NMR (600 MHz, DMSO-d6) 2.93 (3H, d), 3.02 - 3.08 (4H, m), 3.66 - 3.77 (4H, m), 3.90 (3H, s), 6.94 (2H, d), 7.30 (1H, br s), 7.40 (1H, t), 7.59 - 7.64 (3H, m),

7.64 - 7.68 (2H, m), 8.16 (1H, br q), 8.33 (1H, s), 11.23 (1H, s); m/z: (ES+), [M+H]+ = 459.4

Example 8

5-(Methylamino)-6-(3-methylimidazor4 _, 5-clpyridin-7-yl)-3-(4-morpholinoanilino)pyrazine-2- carboxamide

£aj Methyl J _. :amno _: 6-cWorp^5 _: _(methyjaminoJpyrazine^2 _: carbpxyJate 33% Methanamine in EtOH (280 mL, 2.25 mol) was added to a mixture of methyl 3-amino- 5,6-dichloro-pyrazine-2-carboxylate (100 g, 450 mmol) in MeOH (1 L). The resulting mixture was stirred at 65 °C for 16 h. The reaction was then cooled to 0°C, then filtered, washed with MeOH, and dried under vacuum, to afford methyl 3-amino-6-chloro-5- (methylamino)pyrazine-2-carboxylate (69.0 g, 71% yield) as a light beige solid. 1H NMR (500 MHz, DMSO-d6) 2.87 (3H, d), 3.73 (3H, s), 7.27 (2H, br s), 7.55 (1H, br d). m/z: (ES+), [M+H]+ = 217.0 {¾ _. Methyl _. 5-chloro-6 _: (methylaminoJ-2-oxo-lH-pyrazine-3 _: carbpxylate

A solution of sodium nitrite (12.23 g, 177.3 mmol) in water (100 mL) was added dropwise over 2 h to a suspension of methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (32.00 g, 147.7 mmol) in 25% sulfuric acid (400 mL, 1.2 mol), hexane (100 mL) and water (400 mL). The resulting mixture was stirred vigorously at room temperature for 30 min. The reaction was then filtered, washed with water, and dried under vacuum to afford methyl 5- chloro-6-(methylamino)-2-oxo-lH-pyrazine-3-carboxylate (31.4 g, 98% yield) as a pale yellow solid. 1HNMR (500 MHz, DMSO-d6) 2.90 (3H, d), 3.82 (3H, s), 7.97 (1H, br d), 11.50 (1H, s). m/z: (ES+), [M+H]+ = 218.0

(?) Methyl _. 6-chlprg-5-(methy _. larninp) _. :3-(trifluoromethylsulfonylQxy)pyrazine-2-carbpxylate Trifluoromethanesulfonic anhydride (21.4 mL, 126.4 mmol) was added dropwise to a suspension of methyl 5-chloro-6-(methylamino)-2-oxo-lH-pyrazine-3-carboxylate (25.0 g,

115 mmol) and DIPEA (40.0 mL, 230 mmol) in DCM (500 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 30 min. The reaction was then concentrated. The resulting solid was used in the next step without further purification. .(d _. ) _. Methyl _. 6^cUQrg-5:(methylaminoJ-3-(4-moiphphnganilinpJpyrazine -2-carbpxylate

A mixture of methyl 6-chloro-5-(methylamino)-3-(trifluoromethylsulfonyloxy)pyraz ine-2- carboxylate (40.0 g, 114 mmol), 4-morpholinoaniline (24.47 g, 137.3 mmol) and DIPEA (59.9 mL, 343 mmol) was stirred at 100 °C for 3 h. The reaction was then allowed to cool to room temperature, diluted with EtOAc, and filtered. The resulting filtrate was washed with water, dried over sodium sulfate, filtered, and concentrated. The resulting solid was used in the next step without further purification.

£?).. Methyl..5:_(m_ethy]a_mi_np)_-6 _: (_3-met_hyJ_im_i_d_azo[_4,5_-c]pyndi_n_-7:y!).:3 -(4- i?30iThplinoanilinp)pyrazine-2-carbgxylate

A mixture of methyl 6-chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2- carboxylate (25.0g, 66.2 mmol), 3-methyl-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)imidazo[4,5-c]pyridine (20.5 g, 79.1 mmol), PdCb(dppf) dichloromethane adduct (5.40 g, 6.62 mmol), and cesium fluoride (20.10 g, 132.3 mmol) in 1,4-dioxane (500 mL) and water (50 mL) was evacuated and backfilled with nitrogen 3 times. The resulting mixture was stirred at 80 °C for 2 h. The reaction was then allowed to cool to room temperature, diluted with water (500 mL), and filtered. The filter cake was dried under vacuum. The resulting solid was used in the next step without further purification.

(f) _. ^-(MethyLatnjnpJ-fi-fj-methyJimidazofd^-cJpyridin-y-yU-J _. -fd- iPorphplinoanilinp) _. pyrazine-2-carbgxylic acid

2N Aqueous KOH (160 mL, 320 mmol) was added to a suspension of methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-mo rpholinoanilino)pyrazine-2- carboxylate (31.4 g, 66.2 mmol) in MeOH (100 mL) and THF (100 mL). The resulting mixture was stirred at 50 °C for 1 h. The reaction was then allowed to cool to room temperature and acidified with IN HC1 (190 mL, 380 mmol). The resulting mixture was evaporated and the residue was used in the next step without further purification.

.(g).5.-(Me.thy! aminq) _: 6-(3 -methy limi dazo[4 _: 5 -c]p.y ri din _: 7-yl)-3 _: (4- hlorphglinoaniling)pyrazine-2-carbgxamide

DIPEA (69.4 mL, 397 mmol) was added to a mixture of 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxylic acid (30.5 g, 66.2 mmol), ammonium chloride (14.17 g, 264.9 mmol), and HATU (50.40 g, 132.5 mmol) in DMF (400 mL). The reaction mixture was stirred at room temperature for 1 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% methanol-dichloromethane as eluent, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide (15.75 g, 52% yield) as a yellow solid. This material was combined with a batch of equal size and stirred at room temperature for 10 minutes in MeOH (1 L). The resulting slurry was filtered. The solid residue was found to be crystalline by XRPD (form A) and a typical diffractogram is displayed in Figure 1. Characteristic peak positions are listed below in Tables 3 and 4.

Form A was further analyzed by thermal techniques. DSC analysis indicated that Form A starts to de-solvate with an onset at 29 °C and a peak at 54 °C, followed by a several thermal events from 190 °C to 290 °C. TGA indicated that Form A exhibits a mass loss of about 1.3 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form A is shown in Figure 2.

The filter cake consisting of form A was suspended in 99.5% EtOH (750 mL) and treated with 20 mg seed crystals of Form F 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)- 3-(4-morpholinoanilino)pyrazine-2-carboxamide (obtainable by placing 3-5 mg of form A in a TGA or DSC pan, heating to 300°C at a rate of 10°C/minute and then cooled down to the room temperature.) The resulting suspension was stirred at room temperature for 16 hours, then filtered. The filter cake was dried under vacuum to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide (31.5 g) as a yellow solid. The solid residue was found to be crystalline by XRPD (form F) and a typical diffractogram is displayed in Figure 3. Characteristic peak positions are listed below in Tables 5 and 6.

Form F was further analyzed by thermal techniques. DSC analysis indicated that Form F has a melting/decomposition temperature with an onset at 334 °C and a peak at 338 °C. TGA indicated that Form F exhibits a mass loss of about 0.5 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form F is shown in Figure 4.

Single crystals of Form F were obtained from evaporation of the EtOH solution. Single crystal structure analysis confirmed that Form F is an anhydrous form. The molecular structure of Example 8 - Form F is shown in Figure 5. Crystallographic data: Space group monoclinic Pc, unit cell dimensions: a = 7.9965(4) A , b = 9.5420(4) A , c = 14.3408(6) A, b= 92.333(1)°, V = 1093.33(8) A ³ .

By suspending 50 mg of the filter cake consisting of form A in 40 mL of ACN, and stirring the slurry at the room temperature for 5 days, following filtration 45 mg of yellow solid was obtained after filtration and air-drying. The solid residue was found to be crystalline by XRPD (form G) and a typical diffractogram is displayed in Figure 6. Characteristic peak positions are listed below in Tables 7 and 8.

Form G was further analyzed by thermal techniques. DSC analysis indicated that Form G has a melting/decomposition temperature with an onset at 344 °C and a peak at 345 °C. TGA indicated that Form G exhibits a mass loss of about 0.1 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form G is shown in Figure 7.

By suspending 50 mg of the filter cake consisting of form A in 0.5 mL of FLO, 0.5 mL of MeOH, and 0.5 mL of DCM„ and stirring the slurry at the room temperature for 5 days, following filtration 48 mg of yellow solid was obtained after filtration and air-drying. The solid residue was found to be crystalline by XRPD (form I) and a typical diffractogram is displayed in Figure 8. Characteristic peak positions are listed below in Tables 9 and 10.

Form I was further analyzed by thermal techniques. DSC analysis indicated that Form I starts to de-solvate with an onset at 66 °C and a peak at 73 °C, followed by has a melting/decomposition temperature with an onset at 344 °C and a peak at 245 °C. TGA indicated that Form I exhibits a mass loss of about 3.7 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form I is shown in Figure 9.

Single crystals of Form I were obtained from evaporation of the MeOH/DCM/H20 (1:1:1) solution. Single crystal structure analysis confirmed that Form I is a monohydrate form. The molecular structure of Example 8 - form I is shown in Figure 10 Crystallographic data: Space group monoclinic P2(l)/c , unit cell dimensions: a = 21.504(6) A, b = 4.5841(12) A, c = 22.777(6) A, b= 90.683(5)°, V= 2245.2(10) A ³ .

1HNMR (500 MHz, DMSO-d6) 2.94 (3H, d), 3.02 - 3.13 (4H, m), 3.70 - 3.80 (4H, m), 4.02 (3H, s), 6.96 (2H, d), 7.31 (1H, br s), 7.67 (2H, d), 7.71 (1H, br s), 8.00 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.30 (1H, s). m/z: (ES+), [M+H]+ = 459.9

Example 9

6-n-Methylbenzimidazol-4-vD-5-methylsulfanyl-3-(4-morphol inoanilino)pyrazine-2- carboxamide

(a) Methyl _. 3 -amino-6-chlorp- -5 i _r methylsulfanyl _.7 Eyrazine-2 _. -carboxyl ate Aqueous sodium methanethiolate, 21 wt% (22 mL, 66 mmol) was added to a suspension of methyl 3-amino-5,6-dichloro-pyrazine-2-carboxylate (10 g, 45 mmol) in THF (100 mL). The resulting suspension was stirred at 25 °C for 3 hours. The reaction was then concentrated to one-sixth the original volume. The resulting orange suspension was diluted with water (100 mL) and stirred 10 minutes, then filtered, rinsed copiously with water, and dried under vacuum to afford methyl 3-amino-6-chloro-5-methylsulfanyl-pyrazine-2-carboxylate (9.65 g, 92%) as a yellow solid; 1H NMR (500MHz, DMSO-d6,) 2.52 (3H, s), 3.81 (3H, s), 7.59 (2H, br s); m/z: (ES+), [M+H]+ = 233.9.

{¾ _. Methyl _. 3-aming-6-(f-methylbenziinidazpL4-yl)-5:methylsulfanyl -pyrazine-2-carboxylate A mixture of l-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benz imidazole (497 mg, 1.93 mmol), methyl 3-amino-6-chloro-5-methylsulfanyl-pyrazine-2-carboxylate (250 mg, 1.07 mmol), cesium fluoride (488 mg, 3.21 mmol) and PdCh(dppf) (78 mg, 0.11 mmol) in MeOH (5 mL) was degassed and purged with nitrogen. The reaction mixture was stirred at 120 °C for 18 hours in a sealed vial. The reaction mixture was then filtered through Celite and concentrated. The resulting residue was purified by silica gel chromatography, using 0-100% EtOAc-Hexanes as eluent, followed by 0-20% MeOH-DCM as eluent, to afford methyl 3- amino-6-(l-methylbenzimidazol-4-yl)-5-methylsulfanyl-pyrazin e-2-carboxylate (150 mg, 43%) as a dark brown solid, m/z: (ES+), [M+H]+ = 330.1.

{c) _. 6 _: (l _: Methylbenzimidazol:4rylJ-5:methylsulfanyl-3-(_4-rngiph plinganilino)pyrazine-2- carbgxylic _. acid

Methyl 3-amino-6-(l-methylbenzimidazol-4-yl)-5-methylsulfanyl-pyraz ine-2-carboxylate (80 mg, 0.24 mmol) was added to 1,4-dioxane (1.5 mL). The resulting solution was sparged with nitrogen 5 minutes. 4-(4-bromophenyl)morpholine (70.6 mg, 0.29 mmol), BrettPhos Pd G3 (22.02 mg, 0.02 mmol), and sodium tert-butoxide (117 mg, 1.21 mmol) were added to the reactoin mixture, which was then stirred at 80 °C for 2 hours. 1M HC1 was added and the aqueous layer was washed with 3 : 1 DCM/IPA, then concentrated. The resulting residue was used directly in the next step without purification assuming 100% yield. m/z\ (ES+), [M+H]+ = 477.

{dJ _. 6rXlrMethylbenzimidazol-4-yl)-5-methylsulfanyl-3 _: (4-mo^)holinoanilino)pyrazine:2- carboxamide

DIPEA (0.253 mL, 1.45 mmol) was added to a suspension of 6-(l-methylbenzimidazol-4-yl)- 5-methylsulfanyl-3-(4-morpholinoanilino)pyrazine-2-carboxyli c acid (115 mg, 0.24 mmol), ammonium chloride (51.6 mg, 0.97 mmol), and HATU (184 mg, 0.48 mmol) in DMF (2 mL). The resulting mixture was stirred at 25 °C for 90 minutes, then purified directly by reverse phase chromatography on cl8, using 0-80% MeCN-FfO as eluent and 0.1% ammonium hydroxide as modifier, to afford 6-(l-methylbenzimidazol-4-yl)-5-methylsulfanyl-3-(4- morpholinoanilino)pyrazine-2-carboxamide (9.0 mg, 7.8%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 2.41 (3H, s), 3.07 (4H, br s), 3.73 (4H, br d), 3.87 (3H, s), 6.93 - 6.99

(2H, m), 7.29 (1H, br d), 7.33 - 7.39 (1H, m), 7.58 (2H, br d), 7.65 (1H, br d), 7.72 (1H, br s), 7.85 (1H, br s), 8.17 (1H, s), 11.16 (1H, s); m/z: (ES+), [M+H]+ = 476.2

Example 10

5-(Ethylamino)-6-(T-methylbenzimidazol-4-vO-3-(4-morpholi noanilino)pyrazine-2- carboxamide

{4) _. 6:il:Methylbenzimidazol _: 4-yl)-5 _: methylsulfonyl-3 _: £4-(4-oxidomorpholin:4-ium-4- y]j4nriinpJpyrazine-2-carboxamide mCPBA (21 mg, 77 wt%, 0.090 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfanyl-3-(4-morpholinoani lino)pyrazine-2-carboxamide (20 mg, 0.04 mmol) in DCM (1 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 30 minutes and then at 25 °C for 90 minutes. The reaction was then quenched with saturated aqueous sodium bicarbonate and extracted with 3 : 1 DCM/IPA. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-100% MeOH-DCM to afford a yellow material, which was purified further by reverse phase chromatography on cl 8, using 0- 80% MeCN/H20 as eluent and 0.1% ammonium hydroxide as modifier, to afford 6-(l- methylbenzimidazol-4-yl)-5-methylsulfonyl-3-[4-(4-oxidomorph olin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (15.00 mg, 68%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 2.88 (2H, br d), 3.36 (3H, s), 3.78 (2H, dd), 3.90 (3H, s), 4.03 (2H, td), 4.43 (2H, br t), 7.35 - 7.40 (1H, m), 7.45 (1H, d), 7.67 (1H, d), 7.87 (2H, d), 8.16 - 8.24 (3H, m), 8.27 (2H, br s), 11.55 (1H, s); m/r. (ES-), [M-H]- = 522.1. {¾.5-(Eth lamino) _: 6-(l-methylbenzimidazol-4 _: yl)-3-(4-mg^hphn anilino)pyrazine-2- carboxamide

2 M Methanolic ethanamine (0.028 mL, 0.056 mmol) and DIPEA (0.024 mL, 0.14 mmol) were added to a solution of 6-(l-methylbenzimidazol-4-yl)-5-methylsulfonyl-3-[4-(4- oxidomorpholin-4-ium-4-yl)anilino]pyrazine-2-carboxamide (24 mg, 0.050 mmol) in THF (1 mL). The resulting mixture was stirred at 25 °C for 3 hours. Sodium hydrogen sulfite (14.1 mg, 0.140 mmol) was added and the reaction was stirred at 25 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase chromatography on Cl 8, using 0-80% MeCN/FbO as eluent and 0.1% ammonium hydroxide as modifier, to afford 55-(ethylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholin oanilino)pyrazine-2- carboxamide (10.0 mg, 46%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 1.20 (3H, t), 3.02 - 3.11 (4H, m), 3.45 (2H, quintet), 3.68 - 3.76 (4H, m), 3.90 (3H, s), 6.93 (2H, d), 7.33 (1H, br s), 7.36 - 7.49 (1H, m), 7.57 - 7.75 (5H, m), 8.35 (1H, s), 8.43 (1H, br t), 11.22 (1H, s); m/z\ (ES+), [M+H]+ = 473.3.

Example 11

5-(Cvclopropylamino)-6-(l-methylbenzimidazol-4-vn-3-(4-mo rpholinoanilino)pyrazine-2- carboxamide Cyclopropylamine (0.040 mL, 0.57 mmol) and DIPEA (0.10 mL, 0.57 mmol) were added to a solution of 6-(l-methylbenzimidazol-4-yl)-5-methylsulfonyl-3-[4-(4-oxido morpholin-4-ium- 4-yl)anilino]pyrazine-2-carboxamide (100 mg, 0.19 mmol) in DMF (1.5 mL). The resulting mixture was stirred at 25 °C for 1 hour. Sodium hydrogen sulfite (60 mg, 0.57 mmol) was added and the resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by reverse phase chromatography on Cl 8, using 10-80% MeCN/tEO as eluent, to afford 5-(cyclopropylamino)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxamide (20 mg, 22%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) d 0.43 - 0.52 (2H, m), 0.79 - 0.87 (2H, m),

2.88 (1H, ddd), 3.02 - 3.09 (4H, m), 3.69 - 3.76 (4H, m), 3.90 (3H, s), 6.94 (2H, d), 7.35 - 7.43 (2H, m), 7.63 (1H, d), 7.70 (1H, br s), 7.73 (1H, d), 7.80 (2H, d), 8.38 (1H, s), 9.08 (1H, d), 11.24 (1H, s); m/z: (ES+), [M+H]+ = 485.4.

Example 12 5-Amino-6-(T-methylbenzimidazol-4-vD-3-(4-morpholinoanilino) pyrazine-2-carboxamide

{4) _. 6:il:Methylbenzimidazol _: 4-ylJ-5 _: methylsulfinyl-3 _: £4 _: 0-oxidomoipholin _: 4-ium-4- y]j4ndinpJpyrazine-2-carbpxamide

A solution of mCPBA (0.17 g, 0.75 mmol) in DCM (3 mL) was added dropwise to a mixture of 6-(l-methylbenzimidazol-4-yl)-5-methylsulfanyl-3-(4-morpholi noanilino)pyrazine-2- carboxamide (0.157 g, 0.330 mmol) in DCM (5.00 mL) at 0 °C. The reaction was stirred at 0 °C for 5 minutes. The reaction was quenched with saturated aqueous sodium bicarbonate and extracted once with DCM and once with 5:1 DCM/IPA. The combined organic layers were dried over sodium sulfate, concentrated, and used in the next step without purification assuming 100% yield.

{¾ _. 5rAming-6-Q-methylbenzimidazol-4-yl)-3 _: (4 _: mqiphglinqanilinQ) _. pyrazine-2-carboxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to 6-(l-methylbenzimidazol-4-yl)-5- methylsulfmyl-3-[4-(4-oxidomorpholin-4-ium-4-yl)anilino]pyra zine-2-carboxamide (0.255 g, 0.500 mmol). The resulting suspension was stirred at 70 °C for 2.5 hours. The reaction was then concentrated. The resulting residue was suspended in water, then filtered and rinsed with water. The filter cake was dried under vacuum to afford 5-amino-6-(l-methylbenzimidazol-4- yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamide (0.198 g, 88%) as a yellow solid; (500MHz, DMSO-d6) d 3.03 - 3.12 (4H, m), 3.73 - 3.77 (4H, m), 4.05 (3H, s), 6.93 (2H, br d), 7.39 (1H, br s), 7.56 - 7.71 (4H, m), 7.77 (1H, br d), 7.88 (1H, br d), 9.14 - 9.41 (1H, m),

11.22 (1H, s). The amino ML protons were buried underneath the residual water peak m z: (ES+), [M+H]+ = 445.4

Example 13

5-nY2R)-2-Hvdroxypropyllaminol-6-(T-methylbenzimidazol-4- vD-3-(4- morpholinoanilino)pyrazine-2-carboxamide

(R)-l-Aminopropan-2-ol (77 mg, 1.02 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was partitioned between DCM and water. The layers were separated, and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 1% ammonium hydroxide as modifier, to afford 5-[[(2R)-2- hydroxypropyl]amino]-6-(l-methylbenzimidazol-4-yl)-3-(4-morp holinoanilino)pyrazine-2- carboxamide (11 mg, 43%) as a yellow solid; 1H NMR (500 MHz, dichloromethane-d2) d

1.22 (3H, d), 3.02 - 3.09 (1H, m), 3.10 - 3.15 (4H, m), 3.80 - 3.87 (5H, m), 3.90 (3H, s), 4.17 - 4.28 (1H, m), 4.85 (1H, br s), 5.21 (1H, br s), 6.56 (1H, br t), 6.91 (2H, d), 7.43 - 7.56 (3H, m), 7.57 - 7.64 (2H, m), 7.67 (1H, dd), 7.98 (1H, s), 10.86 (1H, s); m/z: (ES+), [M+H]+ = 503.3

Example 14 5-rr(2S)-2-Hvdroxypropyllaminol-6-(l-methylbenzimidazol-4-vn -3-(4- morpholinoanilino)pyrazine-2-carboxamide

(2S)-l-Aminopropan-2-ol (77 mg, 1.02 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was partitioned between DCM and water. The layers were separated, and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 1% ammonium hydroxide as modifier, to afford 5-[[(2S)-2- hydroxypropyl]amino]-6-(l-methylbenzimidazol-4-yl)-3-(4-morp holinoanilino)pyrazine-2- carboxamide (12 mg, 47%) as a yellow solid; 1H NMR (500 MHz, DICHLOROMETHANE- d2) d 1.22 (3H, d), 3.02 - 3.09 (1H, m), 3.09 - 3.17 (4H, m), 3.80 - 3.87 (5H, m), 3.90 (3H, s), 4.18 - 4.27 (1H, m), 4.85 (1H, br s), 5.21 (1H, br s), 6.57 (1H, br t), 6.91 (2H, d), 7.45 - 7.54 (3H, m), 7.59 - 7.63 (2H, m), 7.67 (1H, dd), 7.98 (1H, s), 10.86 (1H, s); m/z : (ES+), [M+H]+

= 503.3

Example 15

6-(T-Methylbenzimidazol-4-vD-3-(4-morpholinoanilino)-5-(2 .2.2- trifluoroethylamino)pyrazine-2-carboxamide

2,2,2-Trifluoroethanamine (101 mg, 1.02 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor. The reaction was then concentrated and the resulting residue was partitioned between DCM and H20. The layers were separated and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0.1% ammonium hydroxide as modifier, to afford 6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-(2,2,2-tr ifluoroethylamino)pyrazine-2- carboxamide (4.2 mg, 16%) as a yellow solid; 1H NMR (500 MHz, DICHLOROMETHANE- d2) d 3.08 - 3.15 (4H, m), 3.80 - 3.87 (4H, m), 3.91 (3H, s), 4.27 (2H, qd), 6.89 - 6.97 (2H, m), 7.45 - 7.60 (5H, m), 7.78 (1H, dd), 7.97 (1H, s), 9.44 (1H, br t), 10.83 (1H, s). One of the carboxamide NH2 protons was exchanged to baseline m z: (ES+), [M+H]+ = 527.2

Example 16

5-(2.2-Difluoroethyla ino)-6-(l -methylbenzimidazol-4-yl )-3 -(4-morpholi noanil i no ipyrazine- 2-carboxamide 2,2-Difluoroethanamine (83 mg, 1.0 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor was heated at 140oc for 20 m. The reaction was then concentrated and the resulting residue was partitioned between DCM and H2O. The layers were separated and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0.1% ammonium hydroxide as modifier, to afford 5-(2,2-difluoroethylamino)-6-(l-methylbenzimidazol-4-yl)-3-( 4- morpholinoanilino)pyrazine-2-carboxamide (9.6 mg, 37%) as a yellow solid; 1H NMR (500 MHz, DICHLOROMETHANE-d2) d 3.09 - 3.15 (4H, m), 3.82 - 3.86 (4H, m), 3.86 - 3.94 (5H, m), 5.45 - 5.59 (1H, m), 6.03 (1H, tt), 6.89 - 6.96 (2H, m), 7.45 - 7.53 (2H, m), 7.54 - 7.64 (3H, m), 7.73 (1H, dd), 7.99 (1H, s), 8.84 (1H, br t), 10.81 (1H, s). m/r. (ES+), [M+H]+

509.2

Example 17

5-r2-(Dimethylamino)ethylamino1-6-(T-methylbenzimidazol-4 -vD-3-(4- morpholinoanilino)pyrazine-2-carboxamide

N',N' -Dim ethyl ethane- 1,2-diamine (90 mg, 1.0 mmol) was added to a suspension of 4-(4-((3- carbamoyl-5-(l-methyl-lH-benzo[d]imidazol-4-yl)-6-(methylsul fmyl)pyrazin-2- yl)amino)phenyl)morpholine 4-oxide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor. The reaction was then concentrated and the resulting residue was partitioned between DCM and H2O. The layers were separated and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0.1% ammonium hydroxide as modifier, to afford 5-[2- (dimethylamino)ethylamino]-6-(l-methylbenzimidazol-4-yl)-3-( 4- morpholinoanilino)pyrazine-2-carboxamide (9.4 mg, 36%) as a yellow solid; 1H NMR (500 MHz, DICHLOROMETHANE-d2) d 2.20 (6H, s), 2.53 - 2.56 (2H, m), 3.08 - 3.13 (4H, m), 3.58 - 3.65 (2H, m), 3.81 - 3.87 (4H, m), 3.90 (3H, s), 5.19 (1H, br s), 6.88 - 6.94 (2H, m), 7.43 - 7.55 (3H, m), 7.63 (1H, dd), 7.66 - 7.70 (2H, m), 7.89 - 7.95 (2H, m), 10.89 (1H, s). m/r (ES+), [M+H]+ = 516.3

Example 18 5-(2-Hvdroxyethylamino)-6-(T-methylbenzimidazol-4-vO-3-(4-mo rpholinoanilino)pyrazine-

2-carboxamide

2-Aminoethanol (62.3 mg, 1.02 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (26 mg, 0.051 mmol) in n-butanol (1 mL). The resulting mixture was stirred at 140 °C for 20 minutes in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was partitioned between DCM and water. The layers were separated, and the organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 1% ammonium hydroxide as modifier, to afford 5-(2- hydroxyethylamino)-6-(l-methylbenzimidazol-4-yl)-3-(4-morpho linoanilino)pyrazine-2- carboxamide (12 mg, 47%) as a yellow solid; 1H NMR (500 MHz, DICHLOROMETHANE- d2) d 3.08 - 3.14 (4H, m), 3.66 (2H, q), 3.80 - 3.87 (6H, m), 3.91 (3H, s), 4.54 (1H, br s), 5.20 (1H, br s), 6.48 (1H, br t), 6.92 (2H, d), 7.42 - 7.56 (3H, m), 7.61 (2H, d), 7.67 (1H, dd), 7.98 (1H, s), 10.88 (1H, s). m/ (ES+), [M+H]+ = 489.3.

Example 19

6-(T-Methylbenzimidazol-4-vO-3-(4-morpholinoanilino)-5-(p rop-2-vnylamino)pyrazine-2- carboxamide

Prop-2-yn-l -amine (0.071 mL, 1.1 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (28 mg, 0.060 mmol) in 1,4-dioxane (1 mL). The resulting mixture was stirred at 110 °C for 30 minutes. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-5% MeOH-DCM, to afford 6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-(pro p-2- ynylamino)pyrazine-2-carboxamide (4.6 mg, 17%) as a yellow solid; 1HNMR (500 MHz, DMSO-d6) d 3.03 - 3.09 (4H, m), 3.11 (1H, t), 3.70 - 3.76 (4H, m), 3.91 (3H, s), 4.16 (2H, dd), 6.93 (2H, d), 7.37 - 7.44 (2H, m), 7.63 - 7.74 (5H, m), 8.37 (1H, s), 8.94 (1H, t), 11.22 (1H, s). m/z: (ES+) [M+H]+ = 483.3

Examples 20 and 21

6-(T-Methylbenzimidazol-4-vD-3-(4-morpholinoanilino)-5-IT rel-(TR.2R)-2- methylcvclopropyllaminolpyrazine-2-carboxamide and 6-( 1 -methylbenzimidazol-4-vD-3-(4- morpholinoanilino)-5-ITrel-(TS.2S)-2-methylcvclopropynamino1 pyrazine-2-carboxamide rac-(lR,2R)-2-Methylcyclopropanamine (30 μL, 0.38 mmol) and DIPEA (340 μL, 1.95 mmol) were sequentially added to a suspension of 6-(l-methylbenzimidazol-4-yl)-5- methylsulfmyl-3-[4-(4-oxidomorpholin-4-ium-4-yl)anilino]pyra zine-2-carboxamide in n- butanol (0.5 mL). The resulting mixture was stirred at 140 °C for 30 minutes in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by reverse phase chromatography on C18, using 0-100% MeCN-H?0 as eluent and 0.1% TFA as modifier, to afford an orange oil. This oil was purified further by chiral HPLC using a Chiralpak AD 4.6 mm x 100 mm 5 micron column, using isocratic 40% methanol-sCC as eluent and 0.2% ammonium hydroxide as modifier, to afford 6-(l-methylbenzimidazol-4-yl)- 3-(4-morpholinoanilino)-5-[[rel-(lR,2R)-2-methylcyclopropyl] amino]pyrazine-2- carboxamide (7.0 mg, 19%) and 6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5- [[rel-(lS,2S)-2-methylcyclopropyl]amino]pyrazine-2-carboxami de (6.5 mg, 18%) as yellow solids; 1HNMR (500 MHz, DMSO-d6) 0.51 - 0.63 (1H, m), 0.64 - 0.70 (1H, m), 0.76 - 0.90

(1H, m), 1.11 (3H, d), 2.63 - 2.68 (1H, m), 2.95 - 3.07 (4H, m), 3.63 - 3.79 (4H, m), 3.90 (3H, s), 6.91 (2H, d), 7.33 - 7.42 (2H, m), 7.62 (1H, d), 7.66 - 7.73 (2H, m), 7.77 (2H, d), 8.37 (1H, s), 8.91 - 8.96 (1H, m), 11.27 (1H, s); m/z: (ES+), [M+H]+ = 499.4

Example 22

5-(Cvanomethylamino)-6-n-methylbenzimidazol-4-vn-3-(4-mor pholinoanilino)pyrazine-2- carboxamide

2-Aminoacetonitrile (0.093 g, 1.7 mmol) was added to a suspension of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (0.042 g, 0.08 mmol) in dioxane (1.5 mL). The resulting mixture was stirred at 110 °C for 30 minutes. The reaction was then quenched with water and extracted with DCM. The organic layer was concentrated. The resulting residue was purified by reverse phase chromatography on cl8, using 10-45% MeCINMEO as eluent and 0.2% ammonium hydroxide as modifier, to afford 5-(cyanomethylamino)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxamide (7.0 mg, 18%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) d 3.04 - 3.13 (4H, m), 3.70 - 3.78 (4H, m), 3.91 (3H, s), 4.37 (2H, d), 6.94 (2H, d), 7.42 (1H, t), 7.48 (1H, br d), 7.62 - 7.71 (4H, m), 7.77

(1H, br s), 8.37 (1H, s), 8.84 (1H, t), 11.27 (1H, s). m/z: (ES+), [M+H]+ = 484.3 Example 23

5-rr(2R)-2-Fluoropropyl1amino1-6-(l-methylbenzimidazol-4- vn-3-(4- morpholinoanilino)pyrazine-2-carboxamide Potassium carbonate (0.12 g, 0.88 mmol) was added to a suspension of (2R)-2-fluoropropan- 1-amine hydrochloride (0.066 g, 0.58 mmol) and 6-(l-methylbenzimidazol-4-yl)-5- methylsulfmyl-3-[4-(4-oxidomorpholin-4-ium-4-yl)anilino]pyra zine-2-carboxamide (0.042 g, 0.08 mmol) in dioxane (1.5 mL). The resulting mixture was stirred at 110 °C for 30 minutes. The reaction was then quenched with water and extracted with DCM. The organic layer was concentrated. The resulting residue was purified by reverse phase chromatography on cl 8, using 10-55% MeCN-FbO as eluent and 0.2% NH ₄ OH as modifier, to afford 5-[[(2R)-2- fluoropropyl]amino]-6-(l-methylbenzimidazol-4-yl)-3-(4-morph olinoanilino)pyrazine-2- carboxamide (7.0 mg, 17%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 1.33 (3H, dd), 3.02 - 3.11 (4H, m), 3.52 - 3.71 (2H, m), 3.71 - 3.80 (4H, m), 3.91 (3H, s), 4.81 - 4.99 (1H, m), 6.93 (2H, d), 7.36 (1H, br d), 7.41 (1H, t), 7.55 (2H, d), 7.64 (1H, d), 7.67 (1H, br d) _:

7.69 (1H, d), 8.35 (1H, s), 8.75 (1H, t), 11.16 (1H, s). m/z: (ES+), [M+H]+ = 505.3

Example 24

5-nY2SV2-Fluoropropyllaminol-6-(T-methylbenzimidazol-4-vD -3-(4- morpholinoanilino)pyrazine-2-carboxamide

Potassium carbonate (0.120 g, 0.88 mmol) was added to a suspension of (26')-2-fluoropropan- 1-amine hydrochloride (0.047 g, 0.41 mmol) and 6-(l-methylbenzimidazol-4-yl)-5- methylsulfmyl-3-[4-(4-oxidomorpholin-4-ium-4-yl)anilino]pyra zine-2-carboxamide (0.042 g, 0.080 mmol) in dioxane (1.5 mL). The resulting mixture was stirred at 110 °C for 30 minutes. The reaction was then quenched with water and extracted with DCM. The organic layer was concentrated. The resulting residue was purified by reverse phase chromatography on Cl 8, using 10-55% MeCN-FbO as eluent and 0.2% NH ₄ OH as modifier, to afford 5-[[(2S)-2- fluoropropyl]amino]-6-(l-methylbenzimidazol-4-yl)-3-(4-morph olinoanilino)pyrazine-2- carboxamide (6.0 mg, 14%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 1.33 (3H, dd), 3.01 - 3.11 (4H, m), 3.52 - 3.71 (2H, m), 3.71 - 3.76 (4H, m), 3.91 (3H, s), 4.80 - 5.01 (1H, m), 6.93 (2H, d), 7.36 (1H, br d), 7.41 (1H, t), 7.55 (2H, d), 7.64 (1H, d), 7.67 (1H, br d), 7.69 (1H, d), 8.35 (1H, s), 8.75 (1H, t), 11.16 (1H, s); m/z (ES+), [M+H] = 505.4

Example 25

6-(T-Methylbenzimidazol-4-vD-3-(4-morpholinoanilino)-5-(o xetan-3- ylmethylamino)pyrazine-2-carboxamide

Oxetan-3-ylmethanamine (36 mg, 0.41 mmol) was added to a solution of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfmyl-3-[4-(4-oxidomorpho lin-4-ium-4- yl)anilino]pyrazine-2-carboxamide (35 mg, 0.070 mmol) in DMF (690 μL). The resulting mixture was stirred at 25 C for 16 hours. The reaction was then quenched with sodium hydrogen sulfite (36 mg, 0.34 mmol) and stirred at 25 C for 1 hour. The resulting mixture was purified directly by Cl 8 reverse phase chromatography, using 0-100% MeCN-FbO as eluent, to afford 6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-(oxe tan-3- ylmethylamino)pyrazine-2-carboxamide; ¹ HNMR (500 MHz, DMSO-d6) 3.05 (4H, t), 3.69

(2H, t), 3.74 (4H, t), 3.90 (3H, s), 4.38 (2H, t), 4.63 - 4.70 (2H, m), 6.93 (2H, d), 7.31 - 7.37 (1H, m), 7.41 (1H, t), 7.58 (2H, d), 7.61 - 7.67 (2H, m), 7.71 (1H, d), 8.34 (1H, s), 8.61 (1H, t), 11.18 (1H, s); the oxetanyl methine proton was buried beneath the residual water peak; m/z: (ES+), [M+H]+ = 515.3 Example 26

5-Ethvnyl-6-(l-methylbenzimidazol-4-vD-3-(4-morpholinoani lino)pyrazine-2-carboxamide {4)MethyIJ _. :amino _: 6-(l-methylbenzimidazol-4 _: yl)-5-(2-triisppropylsilylethynyl)pyrazine:2- carbpxylate

Tricyclohexylphosphonium tetrafluorob orate (136 mg, 0.370 mmol) was added to a mixture of methyl 3-amino-6-chloro-5-(2-triisopropylsilylethynyl)pyrazine-2-ca rboxylate (680 mg, 1.85 mmol), (l-methylbenzimidazol-4-yl)boronic acid (650 mg, 3.70 mmol), potassium phosphate (785 mg, 3.70 mmol), and PCy3 Pd G3 (240 mg, 0.370 mmol) in l,4-dioxane/H ₂ 0 (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-amino-6-(l- methylbenzimidazol-4-yl)-5-(2-triisopropylsilylethynyl)pyraz ine-2-carboxylate (500 mg, 58% yield) as a yellow oil which solidified on standing, m/z: (ES+), [M+H]+ = 464.2 {¾ _. MethyL6-(l-methylbenzimidazol-4 _: yl)-3-(4-rngrpholinpanilino)-5 _: (2- iriisoprppylsily _. lethynyl)pyrazine-2-carbpxylate

BrettPhos Pd G3 (36 mg, 0.040 mmol) was added to a suspension of methyl 3-amino-6-(l- methylbenzimidazol-4-yl)-5-(2-triisopropylsilylethynyl)pyraz ine-2-carboxylate (110 mg, 0.24 mmol), 4-(4-bromophenyl)morpholine (48 mg, 0.20 mmol), and cesium carbonate (193 mg, 0.590 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-(2-triiso propylsilylethynyl)pyrazine-2- carboxylate as a red solid.

{c) _. 6 _: (l _: Methylbenzimidazol _: 4-yl)-3 _: 0-mprpholinoanilino)-5 _: (2- iriisoprppylsi _. ly _. lethynyl)pyrazine-2-carbpxamide 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 6-(l-methylbenzimidazol- 4-yl)-3-(4-morpholinoanilino)-5-(2-triisopropylsilylethynyl) pyrazine-2-carboxylate (260 mg, 0.42 mmol). The resulting mixture was stirred at 70 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography to afford 6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)-5-(2-triiso propylsilylethynyl)pyrazine-2- carboxamide (250 mg, 99%) as a brown solid, m/z: (ES+), [M + H]+ = 610.4 {¾ _. 5rEthynyl:6-(l-rnethylbenzimidazol-4 _: yl)-3-(4-mgipholinpanilino)pyrazine-2- carboxamide

1 M TBAF in THF (2.0 mL, 2.00 mmol) was added to 6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)-5-(2-triisopropylsilylethynyl)pyrazine-2- carboxamide (100 mg, 0.16 mmol) in THF (5 mL). The resulting mixture was stirred at room temperature for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-8% MeOH-DCM as eluent. The resulting residue was purified further by preparative HPLC, using a 5 micron, 19 mm x 150 mm SunFire Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 5-ethynyl-6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (28 mg, 38%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 3.09 (4H, t), 3.72 - 3.79 (4H, m), 3.89 (3H, s), 4.23 (1H, s), 6.99 (2H, d), 7.37 (1H, t), 7.44 - 7.50 (1H, m), 7.53 - 7.62 (2H, m), 7.62 - 7.68 (1H, m), 8.00 (1H, s), 8.10 (1H, s), 8.20 (1H, s), 11.03 (1H, s); m/z: (ES+), [M+H]+ = 454.2

Example 27

5-(DifluoromethvO-6-(T-methylbenzimidazol-4-vO-3-(4-morph olinoanilino)pyrazine-2- carboxamide

(a) Methyl 3 -amino-b-chl oro- 5 _: (difluoromethy l)py razine-2 _: carb oxy 1 ate

Methyl 3-amino-5,6-dichloro-pyrazine-2-carboxylate (500 mg, 2.25 mmol) was added to a mixture of bis(dibenzylideneacetone)palladium (129 mg, 0.230 mmol), DPEPhos (243 mg, 0.450 mmol) and [l,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene]- (difluoromethyl)silver (1.24 g, 2.25 mmol) in toluene (30 mL) under nitrogen. The resulting solution was stirred at 80 °C for 18 hours. The reaction was then concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-50% MeCN-FbO as eluent, to afford methyl 3-amino-6-chloro-5-(difluoromethyl)pyrazine-2-carboxylate (410 mg, 77%) as a brown solid; 1H NMR (400 MHz, CDCh) d 4.02 (3H, s), 6.79 (1H, t); the amino protons exchanged out in CDCh. m/z: (ES+), [M+H]+ = 238.0

{¾ _. Methyl _. 3-aming-5-(diflupromethyl) _: 6-(l-inethylbenzimidazol-4 _: yhpyrazine-2 _: carboxylate Pd(dppf)Ch (123 mg, 0.170 mmol) was added to a mixture of methyl 3-amino-5-chloro-6- (difluoromethyl)pyrazine-2-carboxylate (400 mg, 1.68 mmol), (l-methylbenzimidazol-4- yl)boronic acid (296 mg, 1.68 mmol), and cesium fluoride (511 mg, 3.37 mmol) in 1,4- dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours.

The reaction was then filtered through Celite. The filtrate was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent. The resulting residue was purified by C18 reverse phase chromatography, using 0- 50% MeCN-HiO as eluent, to afford methyl 3-amino-5-(difluoromethyl)-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxylate (120 mg, 21%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 3.78 (3H, s), 3.91 (3H, s), 6.88 (1H, t), 7.34 (1H, dd), 7.42 (1H, t), 7.60 - 7.75 (3H, m), 8.27 (1H, s); m/z: (ES+), [M+H]+ = 334.1 {c)Methy) _.. 5:(difluoxomethyl)-6 _: (f _: methylbenzimidazol-4-yl)-3-(4 _: Plorphglinoaniling)pyrazine-2-carboxyJate

BrettPhos Pd G3 (27 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (difluoromethyl)-6-(l-methylbenzimidazol-4-yl)pyrazine-2-car boxylate (100 mg, 0.30 mmol), 4-(4-bromophenyl)morpholine (73 mg, 0.30 mmol), and cesium carbonate (196 mg, 0.600 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-6% MeOH-DCM as eluent, to afford methyl 5-(difluoromethyl)-6- (l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine- 2-carboxylate (90 mg, 61%) as a yellow solid, m/z: (ES+), [M+H]+ = 495.1

{¾ _. 5rXDifluoromethyl)-6 _: (Lmethylbenzimidazol-4-yl)-3-(4 _: mgrphglinoaniling) _. pyrazine-2- carboxamide 7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 5-(difluoromethyl)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (80 mg, 0.16 mmol). The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 100 mm SunFire Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-FFO as eluent, and 0.1% formic acid as modifier to afford 5-(difluoromethyl)-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxamide (55 mg, 71%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 3.10 (4H, t), 3.75 (4H, t), 3.92 (3H, s), 6.75 - 7.28 (3H, m), 7.45 (1H, t), 7.60 (1H, dd), 7.64 - 7.77 (3H, m), 8.12 (1H, s), 8.31 (2H, s), 11.21 (1H, s); m/z: (ES+), [M+H]+ = 480.3

Example 28

5-Chloro-6-(T-methylbenzimidazol-4-vO-3-(4-morpholinoanil ino)pyrazine-2-carboxamide

(a) _. Methyl J _. :amino ₇ 6-cbJoro-5 ₇ [(4-methQxyphenylJrnethpxyJpyrazine-2-carbpxyJate (4-Methoxyphenyl)methanol (3.42 g, 24.8 mmol) was added to a suspension of methyl 3- amino-5,6-dichloro-pyrazine-2-carboxylate (5.00 g, 22.5 mmol) and potassium phosphate (14.3 g, 67.6 mmol) in MeCN (30 mL). The resulting mixture was stirred at 80 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-amino-6-chloro-5- [(4-methoxyphenyl)methoxy]pyrazine-2-carboxylate (2.3 g, 32%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 3.73 (3H, s), 3.74 - 3.81 (3H, m), 4.41 (2H, s), 6.84 - 6.90 (2H, m), 6.95 (2H, dq), 7.18 - 7.25 (2H, m); m/z: (ES+), [M+H]+ = 324.1

{¾ _. Methyl _. 3-aming-5-[{4 ₇ methoxyphenyl)methoxyl:6 ₇ (l ₇ methylbenzimidazgl-4:yl)pyrazine-

2 _. -c _. arbgxylate

PdCh(dppf) (0.45 g, 0.62 mmol) was added to a suspension of methyl 3-amino-6-chloro-5- [(4-methoxyphenyl)methoxy]pyrazine-2-carboxylate (2.00 g, 6.18 mmol), (1- methylbenzimidazol-4-yl)boronic acid (1.09 g, 6.18 mmol), and cesium fluoride (1.88 g, 12.4 mmol) in 1,4-dioxane (20 mL). The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-amino-5-[(4- methoxyphenyl)methoxy]-6-(l -methylbenzimidazol-4-yl)pyrazine-2-carboxylate (1.80 g, 70%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 3.71 (3H, s), 3.78 (3H, s), 3.87 (3H, s), 5.27 (2H, s), 6.83 (2H, d), 6.91 - 6.98 (2H, m), 7.28 - 7.58 (5H, m), 8.17 (1H, s). m/z: (ES+), [M+H]+ = 420.1

{c)M9thyJ..5:£(4-methgxyphenylJmethoxyJ-6-(l-methylbenzi midazol _: 4-yl)-3 _: 0- i??oiThglinoanriino)pyrazine-2-carbgxylate

Brettphos Pd G3 (0.389 g, 0.430 mmol) was added to a suspension of methyl 3-amino-5-[(4- methoxyphenyl)methoxy]-6-(l-methylbenzimidazol-4-yl)pyrazine -2-carboxylate (1.80 g, 4.29 mmol), 4-(4-bromophenyl)morpholine (1.04 g, 4.29 mmol), and cesium carbonate (4.19 g,

12.9 mmol) in 1,4-dioxane (20 mL). The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% DCM-MeOH as eluent, to to afford methyl 5-[(4- methoxyphenyl)methoxy]-6-(l-methylbenzimidazol-4-yl)-3-(4-mo rpholinoanilino)pyrazine- 2-carboxylate (1.90 g, 76%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) d 3.00 - 3.27 (4H, m), 3.70 (3H, s), 3.70 - 3.80 (4H, m), 3.86 (3H, s), 3.87 (3H, s), 5.27 (2H, s), 6.82 (2H, d), 6.97 (3H, d), 7.18 - 7.27 (3H, m), 7.50 (2H, d), 7.58 (1H, d), 8.20 (1H, s), 10.10 (1H, s). m/z: (ES+), [M+H]+ = 581.3

{^.Methyl 5-hydrgxy-6-(l _: methyJbenzimidazgl-4 _: yl) _: 3-(4-mgrphglinganiling)pyrazine-2 _: carboxylate

Methyl 5-[(4-methoxyphenyl)methoxy]-6-(l-methylbenzimidazol-4-yl)-3 -(4- morpholinoanilino)pyrazine-2-carboxylate (1.8 g, 3.10 mmol) was added to a mixture of TFA (5 mL) and DCM (20 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-hydroxy-6-(l-methylbenzimidazol-4-yl)-3- (4-morpholinoanilino)pyrazine-2-carboxylate (1.10 g, 77%) as a brown solid; 1HNMR (300 MHz, DMSO-d6) d 3.12 - 3.20 (4H, m), 3.74 - 3.81 (4H, m), 3.93 (3H, s), 4.13 (3H, s), 7.02 - 7.07 (2H, m), 7.54 (2H, d), 7.73 (1H, t), 7.97 - 8.03 (1H, m), 8.22 (1H, d), 8.44 (1H, s),

9.70 (1H, s), 10.09 (1H, s); m/z: (ES+), [M+H]+ = 461.2 (e) Methyl 5-chloro-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilin o)p razine _: 2-

Phosphoryl trichloride (5.00 mL, 53.7 mmol) was added to methyl 5-hydroxy-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (0.30 g, 0.65 mmol). The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was redissolved in EtOAc and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-chloro-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (0.200 g, 64%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) 5 3.14 - 3.18 (4H, m), 3.55- 3.59 (4H, m), 3.92 (3H, s), 4.07 (3H, s), 7.04 (2H, d), 7.49 - 7.73 (5H, m), 8.01 (1H, s), 10.00 (1H, s); m/z (ES+), [M+H]+ = 479.2

(t) 6-Cmoro-6-( l-methylbenzimidazol-4-yl)-3-(4-morpholmoamlmojpyrazme-2 carboxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-chloro-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-c arboxylate (200 mg, 0.42 mmol). The resulting suspension was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 30 mm x 150 mm, 5 pm, CSH OBD column, using 20-35% MeCINMhO as eluent and 0.1% formic acid as modifier, to afford 5-chloro-6-(l-methylbenzimidazol-4-yl)-3-(4-morpholinoanilin o)pyrazine- 2-carboxamide (17 mg, 8.8%) as a orange solid; 1H NMR (400 MHz, DMSO-d6) 53.10 (4H, t), 3.75 (4H, t), 3.89 (3H, s), 7.00 (2H, d), 7.35 - 7.46 (2H, m), 7.54 (2H, d), 7.68 (1H, dd), 7.98 (1H, s), 8.08 (1H, s), 8.21 (1H, s), 11.14 (1H, s). m/z (ES+), [M+H]+ = 464.2

Example 29

mCPBA (63 mg, 0.27 mmol) in DCM (2.1 mL) was added dropwise to a solution of 6-(l- methylbenzimidazol-4-yl)-5-methylsulfanyl-3-(4-morpholinoani lino)pyrazine-2-carboxamide (50 mg, 0.11 mmol) in DCM (2.1 mL) at -5 °C. The resulting mixture was stirred at room temperature for 5 minutes. The reaction was then concentrated. The resulting residue was redissolved in NMP (2 mL). 1-methylpyrazol -4-amine (31 mg, 0.32 mmol) was added. The resulting mixture was stirred at 150 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 100 mm Xbridge Cl 8 column, 20-50% MeCN-FbO as eluent, and 0.2% ammonium hydroxide as eluent, to afford a bright yellow solid. This material was suspended in MeOH (2 mL) and sonicated for 30 minutes. The resulting suspension was filtered to afford 6-(l- methylbenzimidazol-4-yl)-5-[(l-methylpyrazol-4-yl)amino]-3-( 4- morpholinoanilino)pyrazine-2-carboxamide (8.0 mg, 15%) as a bright yellow solid; 1H NMR (500MHz, DMSO-d6) d 3.09 - 3.12 (4H, m), 3.67 (3H, s), 3.71 - 3.77 (4H, m), 3.92 (3H, s), 7.00 (2H, br d), 7.32 - 7.40 (4H, m), 7.43 (1H, br t), 7.62 - 7.68 (2H, m), 7.70 (1H, br s), 7.80 (1H, br d), 8.39 (1H, s), 10.79 (1H, s), 10.90 (1H, s); m/r. (ES+), [M+H]+ = 525.4

Example 30

6-(T-Methylbenzimidazol-4-vD-3-(4-morpholinoanilino)-5-(2 -pyridylamino)pyrazine-2- carboxamide

{a) Methyi3-amino:MMorp^5 _: (2 _: pyridylaminoJpyrMne-2 _: carboxylate 60 wt% Sodium hydride in mineral oil (397 mg, 9.92 mmol) was added to a solution of pyridin-2-amine (856 mg, 9.10 mmol) in THF (36 mL). The resulting mixture was stirred at room temperature for 1 hour. Methyl 3-amino-5,6-dichloro-pyrazine-2-carboxylate (1.74 g, 7.85 mmol) and DMF (9 mL) were sequentially added. The resulting suspension was stirred at room temperature for 12 hours. The reaction was then concentrated. The resulting residue was triturated in water, then filtered and dried under air to afford in vacuo and water was added to the mixture. Then the resulting solid was filtered and air-dried to afford methyl 3-amino-6- chloro-5-(2-pyridylamino)pyrazine-2-carboxylate (2.20 g, 95% yield) as a pale yellow solid. 1HNMR (500 MHz, DMSO-d6) 3.98 (3H, s), 7.15 (1H, ddd), 7.75 - 7.92 (3H, m), 8.15 (1H, d), 8.33 (1H, dd), 9.63 (1H, s). m/r. (ES+), [M+2+H]+ = 281.9 {¾ _. MethyL6-cMpxo-3 _: fluorp-5 _: _(2 _: pyridylamino)pyrazine-2 _: carbpxylate Sodium nitrite (154 mg, 2.24 mmol) was added portionwise to a solution of methyl 3-amino- 6-chloro-5-(2-pyridylamino)pyrazine-2-carboxylate (521 mg, 1.86 mmol) in HF*pyridine (8.40 mL, 245 mmol) at -10 °C. The reaction was then stirred at 25 C for 1 hour. The reaction was then quenched with water and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to afford methyl 6-chloro-3-fluoro-5-(2- pyridylamino)pyrazine-2-carboxylate (0.420 g, 80% yield) as an orange solid, m/r (ES-), [M- H]- = 281.3

{c)M9thyJ _.. 6 _: chlprg-3-0-mpiphphnoanilino)-5 _: (2-pyridylamino)pyrazine-2-carbpxylate DIPEA (234 μL, 1.34 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5-(2- pyridylamino)pyrazine-2-carboxylate (189 mg, 0.67 mmol) and 4-morpholinoaniline (119 mg, 0.670 mmol) in DMF (4 mL). The resulting mixture was heated at 100 °C for 12 hours. The reaction was then diluted with water. The resulting precipitate was collected by filtration and air-dried to afford methyl 6-chloro-3-(4-morpholinoanilino)-5-(2-pyridylamino)pyrazine- 2-carboxylate (0.280 g, 95%) as a brown solid, m/r (ES-), [M-H]- = 439.3 {¾ _. 6rCUprp-3-0-mprphplinpanilinp)-5 _: (2-pyridylaminp)pyrazine-2 _: carbpxamide 7 N Methanolic ammonia (4.0 mL, 28 mmol) was added to methyl 6-chloro-3-(4- morpholinoanilino)-5-(2-pyridylamino)pyrazine-2-carboxylate (230 mg, 0.52 mmol). The resulting suspension was stirred at 100 °C for 12 hours. The reaction was then concentrated to afford 6-chloro-3-(4-morpholinoanilino)-5-(2-pyridylamino)pyrazine- 2-carboxamide as a brown solid (165 mg, 74% yield). {?).6:il:Methylbenzimidazol _: 4-ylJ-3 _: 0-mpQ)holinoanilino)-5 _: (2-pyridylaminc))pyrazine-2 _: carboxamide

PdCb(dppf) (28 mg, 0.040 mmol), l-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzimidazole (185 mg, 65 wt%, 0.46 mmol), cesium fluoride (177 mg, 1.16 mmol), and 6-chloro-3-(4-morpholinoanilino)-5-(2-pyridylamino)pyrazine- 2-carboxamide (165 mg, 0.39 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. Dioxane (1.55 mL) and water (0.39 mL) were added. The resulting mixture was stirred at 100 °C for 12 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using 30-70% MeCN-FfO as eluent, and 0.2% ammonium hydroxide as modifier, to afford 6-(l-methylbenzimidazol-4-yl)-3-(4- morpholinoanilino)-5-(2-pyridylamino)pyrazine-2-carboxamide (50 mg, 25%) as pale yellow solid; 1HNMR (400MHz, DMSO-d6) d 3.04 - 3.13 (4H, m), 3.67 - 3.80 (4H, m), 3.95 (3H, s), 6.92 (2H, d), 6.97 (1H, dd), 7.42 - 7.51 (3H, m), 7.55 - 7.65 (2H, m), 7.69 - 7.78 (2H, m), 7.88 (1H, d), 7.91 (1H, br s), 8.17 - 8.24 (1H, m), 8.51 (1H, s), 10.92 (1H, s), 11.05 (1H, s); m/r. (ES+), [M+H]+ = 522.3

Example 31

6-(3-Methylimidazor4.5-clpyridin-7-vD-3-(4-morpholinoanil ino)-5-(oxetan-3-vDpyrazine-2- carboxamide

(a) -amino _: 6-cMorp- 5 _: _(pxetan _: 3 _-yl)py razine-2 -carboxyl ate

Methyl 3-amino-5,6-dichloro-pyrazine-2-carboxylate (500 mg, 2.25 mmol), 4,4'-di-tert-butyl- 2,2'-bipyridine (60 mg, 0.23 mmol), Ir(dFCF3ppy)2(dtbbpy) hexafluorophosphate (25 mg, 0.020 mmol), and NiCh diglyme (50 mg, 0.23 mmol) were combined in a vial, which was sparged with nitrogen for five minutes. DME (13.6 mL) was then added. 3-iodooxetane (400 μL, 4.5 mmol), l,l,l,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane (1.04 mL, 3.38 mmol), and sodium carbonate (477 mg, 4.50 mmol) were sequentially added. The resulting mixture was sparged again with nitrogen for 5 minutes, then stirred in a photoreactor under blue light at ambient temperature, without a cooling fan, for 16 hours. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-30% EtOAc- hexanes as eluent, to afford methyl 3-amino-6-chloro-5-(oxetan-3-yl)pyrazine-2-carboxylate (0.120 g, 22%) as a yellow solid; 1HNMR (500MHz, CHLOROFORM-d) d 3.99 (3H, s), 4.61 (1H, tt), 4.92 - 4.99 (2H, m), 5.00 - 5.06 (2H, m). The NH2 signal exchanged out in chloroform-d; m/z: (ES+), [M+H]+ = 244.1

{¾ _. MethyL6-(3-methylimidazp[4,5-cJp ridin:7- l)-3 _: 4-inprpholinoanilino)-5:(oxetan:3- y _. URyra?ine-2 _: carboxylate

DMF (2.4 mL) was added to a mixture of bis(pinacolato)diboron (299 mg, 1.18 mmol), cataCXium A (17 mg, 0.050 mmol), cataCXium A Pd G3 (34 mg, 0.050 mmol), potassium acetate (139 mg, 1.41 mmol), and 7-bromo-3-methyl-imidazo[4,5-c]pyridine (100 mg, 0.47 mmol). The resulting suspension was sparged with nitrogen for 5 minutes, stirred at 80 °C for 16 hours, and then at 100 °C for 24 hours. The reaction was then allowed to cool to room temperature and set aside.

Sodium nitrite (37 mg, 0.54 mmol) was added to a solution of methyl 3-amino-6-chloro-5- (oxetan-3-yl)pyrazine-2-carboxylate (120 mg, 0.49 mmol) in HF*pyridine (5.30 mL, 155 mmol) at 0 °C. The resulting mixture was allowed to warm to room temperature and stirred for 1 hour. The reaction was then poured into 75 mL of water and extracted three times with DCM (20 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was dissolved in DMF (2.4 mL). DIPEA (85 μL, 0.49 mmol) and 4-morpholinoaniline (87 mg, 0.49 mmol) were sequentially added. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. Pd(dppf)C12 DCM (24 mg, 0.030 mmol) and cesium fluoride (90 mg, 0.59 mmol) were added to the resulting residue. The borylation mixture was added. The resulting suspension was sparged with nitrogen for 5 minutes, then stirred at 100 °C for 2 hours. The reaction was then concentrated onto celite. The resulting material was purified by silica gel chromatography, using 0-10% MeOH-DCM with 0-1% ammonia as eluent, to afford methyl 6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)-5- (oxetan-3-yl)pyrazine-2- carboxylate (0.089 g, 60%) as a brown solid; 1HNMR (500MHz, DMSO-d6) d 3.04 - 3.13 (4H, m), 3.68 - 3.77 (4H, m), 3.91 (3H, s), 4.00 (3H, s), 4.29 - 4.39 (1H, m), 4.51 (2H, dd), 4.67 - 4.75 (2H, m), 6.99 (2H, d), 7.71 (2H, d), 8.36 (1H, s), 8.42 (1H, s), 9.04 (1H, s), 9.99 (1H, s); m/z: (ES+), [M+H]+ = 502.3 {c).6 _: (3 _: Methylimidazo[4 ₃ 5-cJpyridin _: 7-yl)-3 _: (4 _: mo¾hglinoanilinp)-5-(oxetan _: 3-yl)pyrazine _:

2.-cai;boxarnide

7 N methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 6-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-3-((4-morpholinophenyl)amino)-5- (oxetan-3-yl)pyrazine-2- carboxylate (89 mg, 0.18 mmol). The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm, XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-ThO as eluent, and 0.2% ammonium hydroxide as modifier, to afford 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4- morpholinoanilino)-5-(oxetan-3-yl)pyrazine-2-carboxamide (0.016 g, 18%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) 2.97 - 3.16 (4H, m), 3.65 - 3.82 (4H, m), 4.01 (3H, s), 4.29 - 4.46 (1H, m), 4.58 (2H, dd), 4.68 - 4.83 (2H, m), 6.99 (2H, d), 7.75 (2H, d), 7.84 - 7.97 (1H, m), 8.23 (1H, s), 8.44 (1H, s), 8.56 (1H, s), 9.04 (1H, s), 11.20 (1H, s); m/r. (ES+), [M+H]+ = 487.2

Example 32

5-Ethoxy-6-(3-methylimidazor4.5-clpyridin-7-vD-3-(4-morph olinoanilino)pyrazine-2- carboxamide

{a) Ethyl 3-amino _: 6-chloro-5:ethoxy-pyrazine-2 _: carboxylate

21% Sodium ethoxide in ethanol (3.03 mL, 8.11 mmol) was added to a mixture of methyl 3- amino-5,6-dichloro-pyrazine-2-carboxylate (1.20 g, 5.40 mmol) in absolute ethanol (25 mL). The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was treated with water and filtered. The solid was collected, washed with water, and dried to afford ethyl 3-amino-6-chloro-5-ethoxy-pyrazine-2-carboxylate (0.995 g, 75% yield) as a beige solid. 1HNMR (500MHz, DMSO-d6) 1.28 (3H, t), 1.35 (3H, t), 4.26 (2H, q), 4.40 (2H, q), 7.56 (2H, br s). m/z\ (ES+), [M+H]+ = 246.1 {b).6-Chlpro-5-ethpxy-3 _: (4 _: morpholinoaniling)pyrazine _: 2-carboxylic.acid /-BuXPhos Pd G3 (0.133 g, 0.170 mmol) was added to a suspension of ethyl 3-amino-6- chloro-5-ethoxy-pyrazine-2-carboxylate (0.410 g, 1.67 mmol), 4-(4-bromophenyl)morpholine (0.808 g, 3.34 mmol), /-BuXPhos (0.071 g, 0.17 mmol), and sodium /er/-butoxide (0.321 g, 3.34 mmol) in THF (16 mL) under nitrogen. The resulting mixture was stirred at 40 °C for 3 hours. The reaction was then diluted with water and extracted with EtOAc. The organic layer was washed with saturated aqueous sodium bicarbonate and water. The combined aqueous layers were acidified with 1 N HC1. The precipitate was collected by filtration, washed with water, and dried to afford 6-chloro-5-ethoxy-3-(4-morpholinoanilino)pyrazine-2-carboxyl ic acid (0.390 g, 62% yield). 1HNMR (500MHz, DMSO-d6) 1.36 (3H, t), 3.04 - 3.08 (4H, m), 3.71 . 3.74 (4H, m), 4.41 (2H, q), 6.93 (2H, d), 7.47 (2H, d). The NH and COOH protons were broadened into the baseline. m/z\ (ES+), [M+H]+ = 379.3 {c) _. 6:Chlpro-5-ethoxy-3-0-mprpholinoanilino)pyrazin _. e-2-carbpxamide Triethylamine (0.727 mL, 5.22 mmol) was added to a mixture of 6-chloro-5-ethoxy-3-(4- morpholinoanilino)pyrazine-2-carboxylic acid (0.494 g, 1.30 mmol), ammonium chloride (0.349 g, 6.52 mmol), and HATU (0.744 g, 1.96 mmol) in DMF (10 mL). The resulting mixture was stirred at room temperature for 3.5 hours. The reaction was then diluted with saturated aqueous sodium bicarbonate and water. The precipitate was collected by filtration, washed with water, and dried to addord 6-chloro-5-ethoxy-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (0.366 g, 74% yield) as a brown solid. 1HNMR (500MHz, DMSO-d6) 1.37 (3H, t), 3.03 - 3.08 (4H, m), 3.70 - 3.74 (4H, m), 4.42 (2H, q), 6.94 (2H, d), 7.47 (2H, d), 7.65 (1H, br s), 7.87 (1H, s), 11.17 (1H, s). m/z\ (ES+), [M+H]+ = 378.5 (F 5-Ethpxy-6-(3 _: methyhmidazp^4 ₁ 5-c]pyridin-7-yl)-3-()4-mprphplinpanilinp)pyrazine-2 _: carboxamide

A mixture of 2-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazabo rocane (0.069 g, 0.28 mmol), 6-chloro-5-ethoxy-3-(4-morpholinoanilino)pyrazine-2-carboxam ide (0.053 g, 0.14 mmol), and PdCh(dppf) (10.3 mg, 0.0100 mmol) in 2 M aqueous potassium phosphate (0.21 mL, 0.42 mmol) and 1,4-dioxane (1.5 mL) was purged with nitrogen. The reaction mixture was stirred in a microwave reactor at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was washed with water, dried and purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent. The product was further purified by reverse phase C18 flash chromatography, using 0-20% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 5-ethoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (0.041 g, 62% yield) as a yellow solid. 1H NMR (500MHz, DMSO-d6) 1.27 (3H, t), 3.00 - 3.15 (4H, m), 3.67 - 3.80 (4H, m), 3.97 (3H, s),

4.41 (2H, q), 6.97 (2H, d), 7.57 (2H, d), 7.66 (1H, br s), 7.94 (1H, br s), 8.39 (1H, s), 8.65 (1H, s), 8.96 (1H, s), 11.19 (1H, s). m/r. (ES+), [M+H]+ = 475.2

Example 33

6-(3-Methylimidazor4.5-clpyridin-7-vO-3-(4-morpholinoanil ino)-5-( ^' trifluoromethvOpyrazine-

2-carboxamide (a) Ethyl .3 , 3 -di amjnq-2 _: nitroso _: prqp _: 2-enqate

Ethyl 3 -ethoxy-3 -imino-propanoate hydrochloride (5.00 g, 25.6 mmol) was added to 2 M ethanolic ammonia (40 mL, 80 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 minutes at 25 °C for 3.5 hours. A solution of sodium nitrite (1.94 g, 28.1 mmol) in water (8 mL) was added. 6 N aqueous HC1 (15 mL, 90 mmol) was added. The resulting mixture was stirred at 25 °C overnight. The reaction was then concentrated to one-third volume, diluted with water, and neutralized with saturated aqueous sodium bicarbonate. The resulting suspension was filtered, washed with water, and air-dried to afford ethyl 3,3-diamino-2- nitroso-prop-2-enoate (1.59 g, 39%); 1H NMR (500MHz, DMSO-d6) d 1.27 (3H, t), 4.26 (2H, q), 7.53 (2H, br s), 10.08 (2H, br s). Poor behavior by LCMS. (b) _. Ethy] 2,3-di am i nq-3 _r imin o-propaii oate

A mixture of ethyl 3,3-diamino-2-nitroso-prop-2-enoate (0.935 g, 5.88 mmol), 10 wt% palladium on carbon (0.313 g, 0.290 mmol) and 6 M aqueous HC1 (17.0 mL, 102 mmol) in ethanol (25 mL) was stirred under a hydrogen atmosphere at 25 °C for 16 hours. The reaction was then filtered through Celite. The filtrate was concentrated to afford ethyl 2,3-diamino-3- imino-propanoate (1.080 g, quantitative) as a white solid; 1H NMR (500MHz, DMSO-d6) d 1.24 (3H, t), 4.28 (2H, q), 5.24 (1H, s), 9.49 (2H, br s). The amino NH2 and guanidino NH were broadened to basline. m/z\ (ES+), [M+H]+ = 146.1 (cj Ethyl 3 -ami no-5 -(triflu romethy f)p razine-2 _: carb pxy 1 ate and ethyl 3 -amino-6- {trifluoromethyl)pyrazine _: 2-carboxylate

20 wt% Aqueous 3,3,3-trifluoro-2-oxo-propanal (9.96 g, 15.8 mmol) was added to a solution of ethyl 2,3-diamino-3-imino-propanoate (0.854 g, 5.88 mmol) in water (30 mL). Sodium acetate (3.38 g, 41.2 mmol) was added. The resulting mixture was stirred at 25 °C for 16 hours. The reaction was basified with saturated aqueous sodium bicarbonate. The resulting suspension was filtered, washed with water, and air-dried to afford a 1 : 1 mixture of ethyl 3- amino-5-(trifluoromethyl)pyrazine-2-carboxylate and ethyl 3-amino-6- (trifluoromethyl)pyrazine-2-carboxylate (498 mg, 36% yield); 1HNMR (500MHz, DMSO- d6) d 1.32 (3H, t), 4.35 (2H, q), 7.80 (2H, br s), 8.30 (1H, s), 8.67 (1H, s). m/z (ES+),

[M+H]+ = 236.1

_(d)_Ethy! _. 3-amino-6-bromo:5-(triflupromethylJpyrazine-2 carbpxylate N-Bromosuccinimide (0.338 g, 1.90 mmol) was added to a solution of 1:1 ethyl 3-amino-5- (trifluoromethyl)pyrazine-2-carboxylate and ethyl 3-amino-6-(trifluoromethyl)pyrazine-2- carboxylate (0.446 g, 1.90 mmol) in acetonitrile (15 mL). The reaction was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified twice by silica gel chromatography, using 0-20% EtOAc-hexanes as eluent each time, to afford ethyl 3- amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate (0.270 g, 45% yield) as a pale yellow solid; 1H NMR (500MHz, DMSO-d6) d 1.32 (3H, t), 4.36 (2H, q), 7.89 (2H, br s). m/z: (ES+), [M+H]+ = 314.1

(?) Ethyl 3-amino:6-(3-methylimidazp[4,5-cJpyridin _: 7 _. -yl) _. -5 _. : _. (trifluoromethyl)pyrazine:2- carbpxylate

DMF (2 mL) was added to a mixture of 7-bromo-3-methyl-imidazo[4,5-c]pyridine (115 mg, 0.54 mmol), bis(pinacolato)diboron (165 mg, 0.65 mmol), potassium acetate (159 mg, 1.62 mmol), cataCXium A Pd G3 (39 mg, 0.050 mmol), and cataCXium A (19 mg, 0.050 mmol). The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 23 hours. Additional DMF (2 mL) was added. The reaction mixture was evacuated and backfilled three times with nitrogen. The reaction mixture was stirred at 100 °C for 24 hours. The reaction mixture was allowed to cool to room temperature and set aside.

Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate (121 mg, 0.390 mmol), PdCh(dppf) (28 mg, 0.040 mmol), and cesium fluoride (117 mg, 0.770 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then quenched with water. The resulting suspension filtered, washed with water, and air-dried. The filtrate was treated with saturated aqueous sodium bicarbonate, then extracted with 5:1 DCM/IPA. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was combined with the dried filter cake, then purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford ethyl 3- amino-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-5-(trifluoromet hyl)pyrazine-2-carboxylate (0.042 g, 30%) as a brown gum; 1H NMR (500MHz, DMSO-d6) d 1.26 (3H, t), 3.98 (3H, s), 4.33 (2H, q), 7.77 - 7.97 (2H, m), 8.30 (1H, s), 8.37 (1H, s), 9.05 (1H, s). m/r. (ES+), [M+H]+ = 367.2 i0- _. ^"C3^Methylimkd^q£4 _^ 5 _r c]pyridin-7 _r ylJ-3-(4r _. nioipholinpanilino)-5-

{trifluoromethyl)pyrazine: _. 2-carboxyli _. c acid

A mixture of 4-(4-bromophenyl)morpholine (0.056 g, 0.23 mmol), ethyl 3-amino-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-5-(trifluoromethyl)pyrazin e-2-carboxylate (0.085 g, 0.23 mmol), BrettPhos Pd G3 (0.042 g, 0.05 mmol) and cesium carbonate (0.227 g, 0.70 mmol) in 1,4-dioxane (2.0 mL) was evacuated and backfilled three times with nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-35% MeCN-FbO as eluent and 0.1% TFA as modifier, to afford 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4- morpholinoanilino)-5-(trifluoromethyl)pyrazine-2-carboxylic acid (0.025 g, 22%) as a solid; 1H NMR (500MHz, DMSO-d6) d 3.10 - 3.14 (4H, m), 3.73 - 3.75 (4H, m), 4.09 (3H, s), 7.02 (2H, br d), 7.61 (2H, d), 8.71 (1H, s), 8.90 (1H, s), 9.55 (1H, s), 10.41 (1H, s); the COOH proton was broadened and indistinguishable from the baseline; m/z: (ES+), [M+H]+ = 500.3 igi _. b^JrMethylimidazobd^-cJpyridin-y _.T yli _TJ -fd-morphqJinoaniJinq):^- {trifluorpmethyl)pyrazine:2_-carboxamide

DIPEA (0.026 mL, 0.15 mmol) was added to a mixture of 6-(3-methylimidazo[4,5-c]pyridin- 7-yl)-3-(4-morpholinoanilino)-5-(trifluoromethyl)pyrazine-2- carboxylic acid (0.025 g, 0.050 mmol), ammonium chloride (0.013 g, 0.25 mmol), HATU (0.029 g, 0.080 mmol) in DMF (0.80 mL). The resulting mixture was stirred at 25 C for 2 hours. The reaction was then treated with saturated aqueous sodium bicarbonate and extracted with 5:1 DCM-IPA. The organic layer was concentrated. The resulting residue was purified by C18 reverse phase chromatography, using 10-50% MeCN-H?0 as eluent and 0.2% ammonium hydroxide as modifier, to afford 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilin o)-5- (trifluoromethyl)pyrazine-2-carboxamide (18 mg, 72%) as an orange solid; 1HNMR (500 MHz, DMSO-d6) d 3.03 - 3.14 (4H, m), 3.66 - 3.78 (4H, m), 3.99 (3H, s), 7.00 (2H, d), 7.61

(2H, d), 8.13 (1H, br s), 8.26 (1H, br s), 8.40 (1H, s), 8.44 (1H, s), 9.05 (1H, s), 11.28 (1H, s); m/z: (ES+), [M+H]+ = 499.3

Example 34

6-(3 -Methyl imidazor4.5-clpyridin-7-yl )-5-methylsulfanyl-3-(4-morpholinoanilino)pyrazine-

2-carboxamide

{4)M9thyJ _.. 6:£hlprg-3-fluprg-5-methylsulfanyl _: pyrazine _: 2-carbpxylate Sodium nitrite (3.00 g, 43.5 mmol) was added portion-wise to a suspension of methyl 3- amino-6-chloro-5-(methylthio)pyrazine-2-carboxylate (9.65 g, 41.3 mmol) in HF-pyridine (20 mL, 580 mmol) at -10 °C. The reaction was then stirred at 25 °C for 3 hours. The reaction was then diluted with DCM (30 mL) and quenched with water (50 mL). The layers were separated and the aqueous layer was extracted twice with DCM (10 mL each). The combined organics were dried over MgSCL, filtered, and concentrated to afford methyl 6-chloro-3-fluoro-5- methylsulfanyl-pyrazine-2-carboxylate (9.46 g, 97%) as a pale yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.59 (3H, s), 3.88 (3H, s); m/z: (ES+), [M+H]+ = 237.0 {bJ _. Methyl _. 6-cMgxg-5 _: methylpulfanyl-3 _: 0-mgrphglinpaniling)pyrazine-2-carbpxylate DIPEA (4.00 mL, 22.9 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5- methylsulfanyl-pyrazine-2-carboxylate (5.00 g, 21.1 mmol) and 4-morpholinoaniline (3.95 g, 22.2 mmol) in DMF (17 mL). The resulting brown solution was stirred at 100 °C for 15 minutes. The reaction was allowed to cool to room temperature, then filtered, rinsed with EtOAc, and dried under vacuum to afford methyl 6-chloro-5-methylsulfanyl-3-(4- morpholinoanilino)pyrazine-2-carboxylate (6.23 g, 75%) as a light orange solid; 1HNMR (500 MHz, DMSO-d6) 2.50 (3H, s), 3.02 - 3.16 (4H, m), 3.66 - 3.81 (4H, m), 3.89 (3H, s), 6.95 (2H, d), 7.49 (2H, d), 9.92 (1H, s); m/z: (ES+), [M+2+H]+ = 397.0. {c)MethyL6:X3-methylimidAzo^4 ₁ 5 _: c].pyridin-7 _: yl)-5-methylsulfany.l:3.-(4- moiphplinoanilinp)pyrazine-2-carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (1.00 g, 4.72 mmol), bis(pinacolato)diboron (2.39 g, 9.42 mmol), cataCXium A Pd G3 (0.343 g, 0.470 mmol), cataCXium A (0.169 g, 0.470 mmol), and potassium acetate (0.895 g, 9.12 mmol) were combined in a multineck flask, which was evacuated and backfilled three times with nitrogen. DMF (15 mL) was added and the resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature.

Methyl 6-chloro-5-methylsulfanyl-3-(4-morpholinoanilino)pyrazine-2- carboxylate (1.50 g, 3.80 mmol), Pd(dppf)Ch (0.278 g, 0.380 mmol), and cesium fluoride (1.73 g, 11.4 mmol) were combined in a separate multineck flask, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture and the reaction was stirred at 100 °C for 3 hours. The reaction was then allowed to cool to room temperature, diluted with water (150 mL), and extracted three times with 3:1 DCM/IPA (50 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated over Celite. The resulting material was then purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford methyl 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3-(4 - morpholinoanilino)pyrazine-2-carboxylate (0.742 g, 40%) as a dark orange foamy solid; 1H NMR (500 MHz, DMSO-d6) 2.39 (3H, s), 3.05 - 3.15 (4H, m), 3.67 - 3.82 (4H, m), 3.85 (3H, s), 3.99 (3H, s), 6.97 (2H, d), 7.57 (2H, d), 8.32 (1H, s), 8.38 (1H, s), 9.05 (1H, s), 10.05 (1H, s); m/z: (ES+), [M+H]+ = 492.1. i¾ _. 6rX3 _r Methylimjdazo|4 _^ 5-cJpyridin _r 7-yl) _: 5-methy!sulfanyl-3-(4 _r moiphplino^iHnp)pyrazine-2-carboxamide

7 N Methanolic ammonia (6.0 mL, 42 mmol) was added to methyl 6-(3-methylimidazo[4,5- c]pyridin-7-yl)-5-methylsulfanyl-3-(4-morpholinoanilino)pyra zine-2-carboxylate (742 mg, 1.51 mmol). The resulting dark orange solution was stirred at 100 °C for 4 hours in a Biotage microwave reactor. The reaction was allowed to cool to room temperature, then filtered and rinsed with MeOH. The resulting yellow ochre solid was was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3-(4 - morpholinoanilino)pyrazine-2-carboxamide (0.370 g, 51%) as a bright yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.44 (3H, s), 3.01 - 3.12 (4H, m), 3.69 - 3.77 (4H, m), 3.98 (3H, s),

6.97 (2H, d), 7.58 (2H, d), 1.1 (1H, br d), 7.93 (1H, br s), 8.39 (1H, s), 8.42 (1H, s), 9.03 (1H, s), 11.20 (1H, s); m/z: (ES+), [M+H]+ = 477.1.

Example 35

5-r(l-MethylcvclopropyDaminol-6-(3-methylimidazor4.5-clpy ridin-7-vD-3-(4- morpholinoanilino)pyrazine-2-carboxamide mCPBA (194 mg, 0.790 mmol) was added as a solution in DCM (1 mL) to a suspension of 6- (3-methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3-(4-m orpholinoanilino)pyrazine-2- carboxamide (75 mg, 0.16 mmol) in DCM (3 mL) at 0 °C. The resulting suspension was stirred at 25 C for 2 hours. The reaction was then concentrated. The resulting yellow solid was dissolved in DMF (2 mL). 1-methylcyclopropanamine hydrochloride (85 mg, 0.79 mmol) and DIPEA (500 μL, 2.86 mmol) were added and the resulting mixture was stirred at 100 °C for 1 hour. Tetrahydroxy diboron (42 mg, 0.47 mmol) was then added and the resulting mixture was stirred at 100 °C for 5 minutes. The reaction was allowed to cool to room temperature, then diluted with water (20 mL) and extracted three times with 3 : 1 DCM/IPA (25 mL each). The combined organics were washed with 5% aqueous LiCl (10 mL), dried over magnesium sulfate, filtered, and concentrated over Celite. This material was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford 5-[(l-methylcyclopropyl)amino]-6-(3-methylimidazo[4,5-c]pyri din-7-yl)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (18 mg, 23%) as a fluffy yellow solid; 1H NMR (500 MHz, DMSO-d6) 0.70 - 0.82 (4H, m), 1.46 (3H, s), 3.01 - 3.10 (4H, m), 3.70 - 3.77 (4H, m), 4.00 (3H, s), 6.95 (2H, d), 7.35 (1H, br d), 7.76 (1H, br s), 7.83 (2H, d), 8.47 - 8.58 (2H, m), 8.76 (1H, s), 8.98 (1H, s), 11.31 (1H, s); m/z: (ES+), [M+H]+ = 500.2. Example 36

5-Cvano-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-(4-morpho linoanilino)pyrazine-2- carboxamide mCPBA (194 mg, 0.790 mmol) was added as a solution in DCM (1 mL) to a suspension of 6- (3-methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3-(4-m orpholinoanilino)pyrazine-2- carboxamide (75 mg, 0.16 mmol) in DCM (3 mL) at 0 °C. The resulting suspension was stirred for 2 hours at room temperature. The reaction was then concentrated to a yellow solid, which was dissolved in DMF (2 mL). Sodium cyanide (77 mg, 1.57 mmol) was added and the resulting mixture was stirred at 100 °C for 2 hours. The reaction was then allowed to cool to room temperature, treated with sodium bisulfite (82 mg, 0.79 mmol), and stirred for 10 minutes. Additional sodium bisulfite (82 mg, 0.79 mmol) was added and the resulting mixture was stirred for 1 hour. The reaction was then diluted with water (40 mL) and extracted three times with 3:1 DCM/IPA (25 mL each). The combined organics were dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford a red solid. This material was then purified further by preparatory HPLC using a 5 micron, 30 mm x 150 mm Xselect CSH column, 25-50% MeCN-LLO as eluent, and 0.2% ammonium hydroxide as modifier, to afford 5-cyano-6-(3-methylimidazo[4,5-c]pyridin-7-yl)- 3-(4-morpholinoanilino)pyrazine-2-carboxamide (12 mg, 17%) as an orange solid; 1HNMR (500 MHz, DMSO-d6) 3.05 - 3.14 (4H, m), 3.68 - 3.79 (4H, m), 4.02 (3H, s), 7.01 (2H, d), 7.54 (2H, d), 8.12 - 8.32 (1H, m), 8.51 (2H, s), 8.75 (1H, s), 9.10 (1H, s), 11.22 (1H, br s); m/z: (ES+), [M+H]+ = 456.2

Example 37 5-(Cvclopropylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vn-3 -(4- morpholinoanilino)pyrazine-2-carboxamide

A solution of mCPBA (396 mg, 1.61 mmol) in DCM (2 mL) was added dropwise to a suspension of 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-5-methylsulfanyl-3-(4 - morpholinoanilino)pyrazine-2-carboxamide (153 mg, 0.320 mmol) in DCM (3 mL) at -10 C. The reaction was stirred at 25 C for 90 minutes. The reaction was then concentrated. The resulting orange solid was dissolved in DMF (2 mL). Cyclopropylamine (0.050 mL, 0.71 mmol) and DIPEA (0.500 mL, 2.86 mmol) were sequentially added and the reaction was stirred at 25 C for 30 minutes. The reaction was then stirred at 100 C for 1 hour in a Biotage microwave reactor. The reaction was then allowed to cool to room temperature. Sodium bisulfite (0.133 g, 1.28 mmol) was added and the reaction was stirred 10 minutes at room temperature. The reaction was then diluted with water (25 mL) and extracted three times with 3:1 DCM/IPA (20 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford 39 mg of an orange solid. This material was purified further by preparative HPLC, using a 5 micron, 30 mm x 100 mm, Waters XSelect CSH C18 OBD Prep column, 30-60% MeCN-LhO as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5- (cyclopropylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- (4- morpholinoanilino)pyrazine-2-carboxamide (23 mg, 15%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) 0.43 - 0.61 (2H, m), 0.76 - 0.93 (2H, m), 2.89 (1H, tt), 3.00 - 3.12 (4H, m), 3.65 - 3.79 (4H, m), 4.02 (3H, s), 6.96 (2H, d), 7.39 (1H, br s), 7.74 - 7.89 (3H, m), 8.57 (1H, s), 8.81 (1H, br d), 8.84 (1H, s), 9.00 (1H, s), 11.32 (1H, s); m/r. (ES+), [M+H] = 486.2

Example 38 5-Amino-6-(3-methylirnidazor4.5-c1pyridin-7-vD-3-(4-morpholi noanilino)pyrazine-2- carboxamide

{aJ.M.ethyl. J.:ami_no:_6-cbl_oro_-5:_(cxcl_opr_opyJ_ami_no)pxrazi_ne _: 2-carboxylat_e Cyclopropanamine (1.029 g, 18.02 mmol) was added to a suspension of methyl 3-amino-5,6- dichloro-pyrazine-2-carboxylate (1.00 g, 4.50 mmol) in THF (20 mL). The resulting mixture was stirred at 25 C for 4 hours. The reaction was then concentrated. The resulting residue was treated with water. The resulting suspension was filtered, and the solid was dried under vacuum to afford methyl 3-amino-6-chloro-5-(cyclopropylamino)pyrazine-2-carboxylate (1.10 g, quantitative) as an orange solid; 1H NMR (500MHz, DMSO-d6) 0.54 - 0.80 (4H, m), 2.77 - 2.93 (1H, m), 3.72 (3H, s), 7.26 (2H, br s), 7.48 (1H, br d); m/z: (ES+), [M+H]+ = 243.1.

(bJ.Methyl j-aminpA-fcycJppropyJamjnoJ-b-Q-methyljmidazp^^S-cJpyndin-Y- yDpy.razine:?- carboxylate CataCXium A (17 mg, 0.050 mmol), cataCXium A Pd G3 (34 mg, 0.050 mmol), 7-bromo-3- methyl-imidazo[4,5-c]pyridine (100 mg, 0.47 mmol), potassium acetate (139 mg, 1.41 mmol), and bis(pinacolato)diboron (240 mg, 0.94 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (3 mL) was added. The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

Pd(dppf)Ch (35 mg, 0.05 mmol), CsF (107 mg, 0.710 mmol), and methyl 3-amino-6-chloro- 5-(cyclopropylamino)pyrazine-2-carboxylate (114 mg, 0.470 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was heated at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chormatography, using 0-70% MeOH-DCM as eluent, to afford methyl 3-amino-5- (cyclopropylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyr azine-2-carboxylate (80 mg, 50% yield) as an off-white powder.

{c) _. 5:Amino-6-(3-methylimidazp[4,5-cJpyridin _: 7 _. -yl) _. -3 _. : _. (4:morpholinoanilinp) _. pyrazine:2- carboxamide BrettPhos Pd G3 (21 mg, 0.020 mmol) was added to a suspension of methyl 3-amino-5- (cyclopropylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyr azine-2-carboxylate (80 mg, 0.24 mmol), 4-(4-bromophenyl)morpholine (57 mg, 0.24 mmol), and cesium carbonate (154 mg, 0.470 mmol) in 1,4-dioxane (2 mL). The resulting mixture was heated at 90 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-70% MeOH-DCM as eluent, to afford a brown solid. This material was suspended in 7 N methanolic ammonia (510 μL, 3.57 mmol). The resulting suspension was heated to 100 °C for 14 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 19 mm x 150 mm Xbridge Cl 8 column, 20-50% MeCN-ThO as eluent, and 0.2% NH ₄ OH as modifier, to afford 5-amino-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxamide (2.0 mg, 1.9%); 1HNMR (500 MHz, DMSO-d6) 2.99 - 3.11 (4H, m), 3.67 - 3.79 (4H, m), 4.00 (3H, s), 6.91 (2H, d), 7.36 (1H, br s), 7.50 (2H, br s), 7.63 (2H, d), 7.79 (1H, br s), 8.53 (1H, s), 8.80 (1H, s), 8.98 (1H, s), 11.18 (1H, s); m/z: (ES+), [M+H]+ = 446.3

Example 39

6-(3-Methylimidazor4.5-c1pyridin-7-vD-3-(4-morpholinoanil ino)pyrazine-2-carboxamide

(a) MMbyJ _. 6 _r (3 _r methyJjmidazp[4,5 _: clpyridin-7 _r yi)-3-(4-morpholinoaniJino)pyrazine-2- carbpxylate

CataCXium A Pd G2 (17 mg, 0.03 mmol) was added to a suspension of bis(pinacolato)diboron (129 mg, 0.510 mmol), methyl 6-bromo-3-(4- morpholinoanilino)pyrazine-2-carboxylate (100 mg, 0.25 mmol), potassium acetate (75 mg, 0.76 mmol), and bis(l-adamantyl)-butyl-phosphonium tetrafluorob orate (11 mg, 0.030 mmol) in DMF (10 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then allowed to cool to room temperature and set aside.

A mixture of cesium fluoride (97 mg, 0.64 mmol), 7-bromo-3-methyl-imidazo[4,5-c]pyridine (54 mg, 0.25 mmol), and PdCh(dppf) (18.61 mg, 0.03 mmol) was evacuated and backfilled three times. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was taken up in MeOH (10 mL). Thionyl chloride (2.00 mL, 27.4 mmol) was added. The resulting mixture was stirred at 60°C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilin o)pyrazine-2- carboxylate (30 mg, 27%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) 5 3.11 (4H, t), 3.72 - 3.81 (4H, m), 4.02 (3H, s), 4.05 (3H, s), 6.99 (2H, d), 7.55 - 7.63 (2H, m), 8.57 (1H, s), 9.01 (1H, s), 9.06 (1H, s), 9.82 (1H, d), 9.96 (1H, s). m/z\ (ES+), [M+H]+ = 446.2 _. (bJ _. brfj-MethyJimidazobd^-cjpyridin-y _.T yli _TJ -fft-morphpJinoanilinoJpyrazine-^-carbpxarnide 7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to a suspension of methyl 6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxylate (30 mg, 0.07 mmol) in MeOH (1 mL). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xbridge Shield RP18 OBD column, 12-22% MeClNMbO as eluent, and 0.1% formic acid as modifier, to afford 6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamide (10 mg, 35%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) 5 3.04 - 3.14 (4H, m), 3.70 - 3.79 (4H, m), 4.02 (3H, s), 6.92 - 7.02 (2H, m), 7.55 - 7.66 (2H, m), 8.04 (1H, s), 8.55 (1H, s), 8.73 (1H, s), 9.00 (1H, s), 9.45 (1H, s), 9.90 (1H, s), 11.28 (1H, s); m/z\ (ES+), [M+H]+ = 431.1

Example 40

5-Methoxy-6-(3-methylimidazor4.5-clpyridin-7-vD-3-(4-morp holinoanilino)pyrazine-2- carboxamide

{a) _. 6:Chl ro-5-meth xy-3 _: (4 morpholin aniling) yrazine _: 2-carboxamide 7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 6-chloro-5-methoxy-3-(4- morpholinoanilino)pyrazine-2-carboxylate (555 mg, 1.47 mmol). The resulting suspension was stirred at 100 °C in an Emrys microwave reactor for 2 hours. The reaction was then filtered and rinsed with MeOH. The filter cake was dried under vacuum to afford 6-chloro-5- methoxy-3-(4-morpholinoanilino)pyrazine-2-carboxamide (291 mg, 61%) as a yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.99 - 3.10 (4H, m), 3.69 - 3.77 (4H, m), 3.99 (3H, s), 6.94 (2H, d), 7.43 - 7.57 (2H, m), 7.66 (1H, br s), 7.89 (1H, s), 11.19 (1H, s) m/z: (ES-), [M-H]- = 362.3

{¾ _. 5rMethpxy-6-(3-methy/hmidazp^4,5-c] _. pyridin-7-yl)-3-(4-rnprphplinpanilino)pyrazine-2 _: carboxamide

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (100 mg, 0.47 mmol), bis(pinacolato)diboron (299 mg, 1.18 mmol), cataCXium A (17 mg, 0.050 mmol), cataCXium A Pd G3 (34 mg, 0.050 mmol), and potassium acetate (139 mg, 1.41 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.3 mL) was added and the resulting mixture was stirred at 80 °C for 24 hours. The reaction mixture was allowed to cool to room temperature and set aside.

6-Chloro-5-methoxy-3-(4-morpholinoanilino)pyrazine-2-carb oxamide (137 mg, 0.380 mmol), Pd(dppf)Ch dichloromethane adduct (31 mg, 0.040 mmol), and cesium fluoride (172 mg,

1.13 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation reaction mixture was added to the vial via syringe. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was allowed to cool to room temperature, diluted with water (40 mL), and filtered. The filter cake was purified by reverse phase chromatography, using 0-50% MeCN-H?0 as eluent and 0.1% trifluoroacetic acid as modifier, to afford an orange residue. The aqueous filtrate was diluted with saturated aqueous sodium bicarbonate (20 mL) and extracted three times with 3:1 DCM/IPA (30 mL each). The combined organic layers were concentrated. The resulting residue was purified by reverse phase chromatography using 0-50% MeCN-FbO as eluent and 0.1% trifluoroacetic acid as modifier, to afford an orange residue. The orange residues from the two columns were dissolved in water (20 mL), basified with saturated aqueous sodium bicarbonate (10 mL), and extracted three times with DCM (20 mL each). The combined organics were dried over magnesium sulfate, filtered, and concentrated to afford 5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamid e (50 mg, 29%) as a yellow solid. 1H NMR (500MHz, DMSO-d6) 3.01 - 3.11 (4H, m), 3.67 - 3.77 (4H, m), 3.92 (3H, s),

3.97 (3H, s), 6.97 (2H, d), 7.60 (2H, d), 7.67 (1H, br s), 7.94 (1H, br s), 8.38 (1H, s), 8.60 (1H, s), 8.97 (1H, s), 11.22 (1H, s); m/z: (ES+), [M+H]+ = 461.3

Example 41

5-Cvclopropyl-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-(4- morpholinoanilino)pyrazine-2- carboxamide

£a) _.. M _. 9thyJ _.. 6:£hJ_orp-5-cy_cl_oprqpyJ_ _: _3_-tl_uoro _: pyrazi_ne _: 2-carbqxylat_e

Sodium nitrite (68.4 mg, 0.990 mmol) was added to a solution of methyl 3-amino-6-chloro-5- cyclopropyl-pyrazine-2-carboxylate (215 mg, 0.940 mmol) in HF-pyridine (3.0 mL, 87 mmol) at 0 °C. The reaction was stirred at 25 °C for 30 minutes. The reaction was then diluted with DCM (5 mL) and quenched with water (20 mL). The layers were separated and the aqueous layer was extracted with DCM (10 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated to afford methyl 6-chloro-5-cyclopropyl-3-fluoro-pyrazine- 2-carboxylate (0.233 g, quantitative) as a yellow oil; 1H NMR (500 MHz, DMSO-d6) 1.03 - 1.13 (2H, m), 1.25 - 1.34 (2H, m), 2.50 - 2.56 (1H, m), 3.89 (3H, s); m/z: (ES+), [M+H]+ = 231.1

{b) _. Methyl _. 6-chlorq-5 _: cyclppropyl-3-(_4-mgrpholinqanilino)pyrazine-2-carboxy late DIPEA (0.180 mL, 1.03 mmol) was added was added to a solution of methyl 6-chloro-5- cyclopropyl-3-fluoro-pyrazine-2-carboxylate (0.217 g, 0.940 mmol) and 4-morpholinoaniline (0.176 g, 0.990 mmol) in DMF (3 mL). The reaction was stirred at 100 °C for 40 minutes.

The reaction was then allowed to cool to room temperature, diluted with water (80 mL), and extracted three times with EtOAc (25 mL each). The combined organic layers were washed once with 5% aqueous lithium chloride (15 mL), then dried over sodium sulfate, filtered, and concentrated. The resulting red solid was purified by silica gel chromatography, using 0-80% EtOAc-hexanes as eluent, to afford methyl 6-chloro-5-cyclopropyl-3-(4- morpholinoanilino)pyrazine-2-carboxylate (0.213 g, 58%) as an orange solid; 1H NMR (500 MHz, DMSO-d6) 0.95 - 1.09 (2H, m), 1.11 - 1.22 (2H, m), 2.39 - 2.44 (1H, m), 2.97 - 3.15 (4H, m), 3.66 - 3.77 (4H, m), 3.89 (3H, s), 6.93 (2H, d), 7.40 (2H, d), 9.75 (1H, s); m/z: (ES-), [M-H]- = 387.2

(?) _. Methyl 5 rCyclopropyl-6 _: (3 _T methyJirn i dazoL4,5 _T c]pyridin-7:y ] J:3 - _. (4- moiphqlinoanilinq)pyrazine-2-carbpxylate

Methyl 6-chloro-5-cyclopropyl-3-(4-morpholinoanilino)pyrazine-2-car boxylate (107 mg, 0.270 mmol), 2-(3-methylimidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaboroca ne (99 mg, 82 wt%, 0.33 mmol), Pd(dppf)Ch (23 mg, 0.030 mmol), and CsF (125 mg, 0.820 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. MeOH (1.7 mL) was added and the resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting red residue was purified by silica gel chromatography, using 0-10% methanol -DCM as eluent and 0-1% ammonia as modifier, to afford methyl 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-(4-morpholinoanilino)pyrazine-2-carboxylate (0.061 g, 46%) as an orange solid; 1H NMR (500 MHz, DMSO-d6) 0.84 - 0.94 (2H, m), 0.97 - 1.08 (2H, m), 1.79 - 1.88 (1H, m), 2.98 - 3.14 (4H, m), 3.65 - 3.78 (4H, m), 3.87 (3H, s), 3.99 (3H, s), 6.96 (2H, d), 7.51 (2H, d), 8.39 (1H, s), 8.42 (1H, s), 9.05 (1H, s), 9.90 (1H, s); m/z: (ES+), [M+H]+ = 486.2. {d) _. 5rCycloprgpyl-6 _: {3 _: methyhmidazg[4 _^ 5 _: c]pyridin-7 _: yl) _: 3-_(4_-morphplinganilino)pyrazine- 2.-.carbgxarnide

7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxylate (61 mg, 0.13 mmol). The resulting suspension was stirred at 100 °C for 1 hour in a Biotage microwave reactor. Additional 7 N methanolic ammonia (1.0 mL, 7.0 mmol) was added and the reaction was stirred at 100 °C for 1 h in a Biotage microwave reactor. The reaction was then filtered and rinsed with methanol to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- (4-morpholinoanilino)pyrazine-2-carboxamide (0.036 g, 61%) as a yellow ochre solid; 1H NMR (500 MHz, DMSO-d6) 0.83 - 0.97 (2H, m), 0.99 - 1.12 (2H, m), 1.86 - 1.98 (1H, m), 3.01 - 3.12 (4H, m), 3.66 - 3.82 (4H, m), 4.00 (3H, s), 6.97 (2H, d), 7.54 (2H, d), 7.80 (1H, br s), 8.06 (1H, s), 8.45 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 11.08 (1H, s)

Example 42

5-(DifluoromethvD-6-(3-methylimidazor4.5-clpyridin-7-vD-3 -(4-morpholinoanilino)pyrazine-

2-carboxamide

{4)MethyIJ _. :aminQ-6-bromo-pyrazine-2 _: carboxylate

Acetonitrile (100 mL) was added to a mixture of methyl 3-aminopyrazine-2-carboxylate (5.00 g, 32.7 mmol) and N-bromosuccinimide (5.81 g, 32.7 mmol). The resulting solution was stirred at 80 °C for 45 minutes. The reaction was then concentrated. The resulting red solid was triturated in isopropanol (100 mL) and filtered to afford a red solid. The filtrate was concentrated to a red solid and recombined with the filtercake, which was dissolved in DCM (60 mL) and washed once with saturated aqueous sodium thiosulfate (50 mL) and three times with saturated aqueous sodium bicarbonate (25 mL each). The organic layer was then dried over magnesium sulfate, filtered, and concentrated to afford a red solid, which was divided into two portions. One portion was purified by silica gel chromatography using 0-40% EtOAc-hexanes as eluent to afford methyl 3-amino-6-bromopyrazine-2-carboxylate (1.33 g, 18%) as an off-white solid. The other portion was suspended in MeOH, then filtered, rinsing copiously with MeOH, to afford methyl 3-amino-6-bromopyrazine-2-carboxylate (2.89 g, 38%) as a beige microcrystalline solid; 1H NMR (500 MHz, DMSO-d6) 3.84 (3H, s), 7.53 (2H, br s), 8.41 (1H, s); m/z: (ES+), [M+H]+ = 232.0 {b) _. Methyl _. 3-aming-6-bromo _: 5-(difluoromethyl)p_yrazine _: 2-carboxylate TFA (0.66 mL, 8.6 mmol) was added to a suspension of methyl 3-amino-6-bromo-pyrazine-2- carboxylate (1.00 g, 4.31 mmol) and zinc difluoromethanesulfmate (2.55 g, 8.62 mmol) in DCM (10 mL) and water (4 mL). 70 wt% aqueous tert-butyl hydroperoxide (1.80 mL, 13.1 mmol) was added dropwise to the reaction mixture. The reaction mixture was stirred at 25 °C for 16 hours. Additional zinc difluoromethanesulfmate (2.55 g, 8.62 mmol) and 70 wt% aqueous tert-butyl hydroperoxide (1.80 mL, 13.1 mmol) were added and the reaction was stirred at 25 °C for 2 days. The reaction was then quenched with saturated aqueous sodium bicarbonate (50 mL) and diluted with DCM (50 mL) and saturated aqueous ammonium chloride (20 mL). The layers were separated and the aqueous layer was extracted twice with DCM (20 mL each). The combined organics were dried over sodium sulfate, filtered, and concentrated. The resulting pale yellow solid, which was purified by silica gel chromatography, using 0-35% EtOAc-hexanes as eluent, to afford methyl 3-amino-6-bromo- 5-(difluoromethyl)pyrazine-2-carboxylate (0.16 g, 13%) as a pale yellow solid; 1H NMR (500 MHz, DMSO-d6) 3.87 (3H, s), 7.03 (1H, t), 7.34 - 8.32 (2H, br s); m/z: (ES+), [M+H]+ = 282.0

{c)M?thyJ _.. 6-bromq-5 _: (diflupromethylJ _: 3-(4-moiphphnpanilinpJpyrazine-2-carboxylate Sodium nitrite (63 mg, 0.91 mmol) was added to a solution of methyl 3-amino-6-bromo-5- (difluoromethyl)pyrazine-2-carboxylate (245 mg, 0.870 mmol) in HF-pyridine (3.0 mL, 87 mmol) at 0 °C. The reaction was stirred at 25 °C for 15 minutes. The reaction was then diluted with DCM (5 mL) and quenched with water (20 mL). The layers were separated and the aqueous layer was extracted twice with DCM (10 mL each). The combined organics were dried over sodium sulfate, filtered, and concentrated to afford a pale yellow oil. 4- morpholinoaniline (0.163 g, 0.910 mmol) was added to the oil and the resulting mixture was dissolved in DMF (2 mL). DIPEA (0.17 mL, 0.97 mmol) was added to the reaction mixture. The resulting solution was stirred at 100 °C for 30 minutes. The reaction was allowed to cool to room temperature, then diluted with water (70 mL). The resulting suspension was filtered. The filter cake was dried under vacuum to afford methyl 6-bromo-5-(difluoromethyl)-3-(4- morpholinoanilino)pyrazine-2-carboxylate (0.337 g, 87%) as a brick red solid; 1H NMR (500 MHz, DMSO-d6) 3.00 - 3.13 (4H, m), 3.65 - 3.77 (4H, m), 3.94 (3H, s), 6.95 (2H, d), 7.08 (1H, t), 7.53 (2H, d), 9.89 (1H, s); m/z: (ES+), [M+H]+ = 443.1 {dJ _. MethyLS^difluprpmethylX-e-Q^methylimidazp^S^cJpyridin- y^ylJ^-Xfl- i??oiphplinpanilinp)pyrazine-2-carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (176 mg, 0.830 mmol), cataCXium A Pd G3 (60 mg, 0.08 mmol), cataCXium A (30 mg, 0.08 mmol), bis(pinacolato)diboron (527 mg, 2.08 mmol), and potassium acetate (244 mg, 2.49 mmol) were combined in a microwave vial, which was then evacuated and backfilled three times with nitrogen. DMF (3.5 mL) was added and the reaction mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature and set aside.

Separately, methyl 6-bromo-5-(difluoromethyl)-3-(4-morpholinoanilino)pyrazine-2 - carboxylate (337 mg, 0.760 mmol), Pd(dppf)Ck (61 mg, 0.081 mmol), and CsF (378 mg, 2.49 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The reaction mixture from the borylation step was added via syringe. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then allowed to cool to room temperature, diluted with water (30 mL), and extracted three times with 3:1 chloroform/isopropanol (30 mL each). The combined organic layers were washed once with 5% aqueous lithium chloride, then dried over sodium sulfate, filtered, and concentrated. The resulting red residue was purified by silica gel chromatography, using 0-5% methanol-DCM as eluent and 0-0.5% ammonia as modifier, to afford methyl 5-(difluoromethyl)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino)pyr azine-2-carboxylate (0.12 g, 29%) as a dark red solid; 1H NMR (500 MHz, DMSO-d6) 3.07 - 3.13 (4H, m), 3.72 - 3.77 (4H, m), 3.93 (3H, s), 4.01 (3H, s), 6.90 - 7.14 (3H, m), 7.66 (2H, d), 8.48 (2H, d), 9.08 (1H, s), 9.99 (1H, s); m/z: (ES+), [M+H]+ = 496.1 (e) 5-(Difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin _: 7-y!)-3-(4 _:

7 N Methanolic ammonia (2.00 mL, 14.0 mmol) was added to methyl 5-(difluoromethyl)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-(4-morpholinoanilino) pyrazine-2-carboxylate (120 mg, 0.24 mmol). The resulting suspension was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The resulting suspension was filtered, rinsing sparingly with methanol, to afford 5-(difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- (4- morpholinoanilino)pyrazine-2-carboxamide (0.060 g, 52%) as an orange solid; 1H NMR (500 MHz, DMSO-d6) 3.00 - 3.18 (4H, m), 3.67 - 3.83 (4H, m), 4.00 (3H, s), 6.99 (2H, d), 7.11 (1H, t), 7.67 (2H, d), 8.10 (1H, br s), 8.40 (1H, br s), 8.50 (1H, s), 8.69 (1H, s), 9.07 (1H, s), 11.24 (1H, s); m/z: (ES+), [M+H]+ = 481.3

Example 43

5-Methyl -6-(l-methylimidazor4,5-dlpyridazin-4-yl)-3-(4-morpholinoani lino)pyrazine-2- carboxamide

{4)MethyL6:bromo-3 _: flupro-5:methyl:pyrazine-2-carboxylate

Sodium nitrite (1.750 g, 25.36 mmol) was added portionwise to a solution of methyl 3-amino- 6-bromo-5-methyl-pyrazine-2-carboxylate (1.56 g, 6.34 mmol) in pyridine*HF (20.0 mL, 583 mmol) at -10 °C. The resulting mixture was stirred at -10 °C for 2.5 hours. The reaction was then neutralized with saturated aqueous sodium bicarbonate (450 mL), then extracted with EtOAc. The organic layer was washed with brine, dried over magnesium sulfate, filtered, and concentrated to afford methyl 6-bromo-3-fluoro-5-methyl-pyrazine-2-carboxylate (1.400 g, 89 %). 1HNMR (500 MHz, DMSO-d6) d 2.63 (3H, s), 3.90 (3H, s). m/z: (ES+), [M+2+H] = 251.0 iM _. Methy! _. 6-brpmp-5 _r methjJ-3-(4r _. nio^hoHnganilino)pyr^ine-2 _r carbc)xy _. late DIPEA (0.926 mL, 5.30 mmol) was added to a solution of 4-morpholinoaniline (1.01 g, 5.64 mmol) and methyl 6-bromo-3-fluoro-5-methyl-pyrazine-2-carboxylate (1.32 g, 5.30 mmol) in DMF (10 mL). The resulting mixture was stirred at 110 °C for 1 hour in a Biotage microwave reactor. The reaction mixture was concentrated and used directly in the next step, assuming 100% yield.

{c) _. 6 _: Bromo-5-methyl-3 _: (4 _: morpholinoaniling)pyrazine _: 2-carboxamide 7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 6-bromo-5-methyl-3-(4- morpholinoanilino)pyrazine-2-carboxylate (2.29 g, 5.63 mmol). The resulting suspension was stirred at 25 °C for 3 days. The reaction was then concentrated. The resulting residue was suspended in DCM (10 mL) and 7 N methanolic ammonia (40 mL, 280 mmol) was added. The resulting mixture was stirred at 25 °C for 16 hours. The resulting suspension was filtered, washed with MeOH and water, and dried under vacuum to afford 6-bromo-5-methyl-3-(4- morpholinoanilino)pyrazine-2-carboxamide (1.92 g, 87%) as an organge solid; 1HNMR (500MHz, DMSO-d6) 2.50 (3H, s), 2.99 - 3.14 (4H, m), 3.66 - 3.80 (4H, m), 6.85 - 6.99 (2H, m), 7.42 - 7.54 (2H, m), 7.89 (1H, s), 8.11 (1H, s), 10.93 (1H, s). m/z: (ES+), [M+2+H] = 394.1 £d).3_-M_ethyJ-6H-i_iTiidazo[_4,5_-d]pxri_dazin-7-on_e

Hydrazine hydrate (0.267 mL, 3.52 mmol) was added to a solution of ethyl 5-formyl-l- methyl-imidazole-4-carboxylate (0.534 g, 2.93 mmol) in ethanol (20 mL). The resulting mixture was stirred at 25 °C for 90 minutes. Acetic acid (0.839 mL, 14.7 mmol) was then added. The resulting mixture was stirred at 100 °C for 19 hours. The reaction mixture was then concentrated. The resulting residue was suspended in EtOH, filtered, washed with EtOH, and dried under vacuum to afford 3-methyl-6H-imidazo[4,5-d]pyridazin-7-one (0.355 g, 81%) as a white solid; 1HNMR (500MHz, DMSO-d6) 3.88 (3H, s), 8.23 (1H, s), 8.45 (1H, s),

12.63 (1H, br s). m/z\ (ES+), [M+H ₃ 0]+ = 169.2 (e) 4:Chlpro _: X-methyl-imidazp[ _i 4 ₁ 5 _: d] _. pyridazine

Phosphoryl trichloride (6.00 mL, 64.4 mmol) was added to 1 -methyl- l,5-dihydro-4H- imidazo[4,5-d]pyridazin-4-one (0.210 g, 1.40 mmol). The reaction mixture was stirred at 100 °C for 5.5 hours. The reaction mixture was then concentrated. The residue was treated with ice-water, basified with saturated aqueous sodium bicarbonate, and extracted with 5:1 DCM/IPA. The organic layer was dried over magnesium sulfate, filtered, concentrated to afford 4-chloro-l-methyl-imidazo[4,5-d]pyridazine (0.208 g, 88%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 4.00 (3H, s), 8.68 (1H, s), 9.71 (1H, s); m/z\ (ES+), [M+H]+ = 169.1

{0 _. 5-M9thyJ _. :6-(l-methylimidazo[4,5-d]pyridazin _: 4-yl)-3 _: (4 _: morpholinoaniling)pyrazine _: 2- carboxamide

1,4-Dioxane (1.5 mL) was added to a mixture of bis(pinacolato)diboron (0.040 g, 0.16 mmol), 6-bromo-5-methyl-3-(4-morpholinoanilino)pyrazine-2-carboxami de (0.052 g, 0.13 mmol), PdCh(dppf) (9.70 mg, 0.01 mmol), and potassium acetate (0.026 g, 0.27 mmol). The resulting mixture was evacuated and backfilled with nitrogen, then stirred at 80 °C for 3 hours. The reaction was allowed to cool to room temperature and set aside.

MeOH (1 mL) was added to a mixture of 4-chloro-l-methyl-imidazo[4,5-d]pyridazine (0.044 g, 0.26 mmol), PdCh(dppf) (9.5 mg, 0.010 mmol), and potassium phosphate (0.055 g, 0.26 mmol). The borylation mixture was added via syringe. The resulting mixture was evacuated and backfilled with nitrogen, then stirred at 100 °C for 4 hours. The reaction mixture was diluted with water and the resulting suspension was filtered. The filtrate was extracted with DCM. The organic layer was concentrated. The resulting residue was combined with the filter cake and purified by silica gel chromatography, using 0-15% MeOH-DCM, to afford a yellow solid. This material was purified further by reverse phase chromatography, Cl 8, using 0-20% MeCN-ThO as eluent and 0.1% formic acid as modifier, to afford 5-methyl-6-(l- methylimidazo[4,5-d]pyridazin-4-yl)-3-(4-morpholinoanilino)p yrazine-2-carboxamide (0.018 g, 31%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) 2.51 (3H, s), 3.04 - 3.12 (4H, m),

(1H, s), 9.73 (1H, s), 11.08 (1H, s). m/z: (ES+), [M+H]+ = 446.3

Example 44

5-Methyl -6-(7-methylimidazor4.5-c1pyridazin-4-v0-3-(4-morpholinoanil ino)pyrazine-2- carboxamide

.(aJ.^.r.CLb.LPXPrKj.-.rn.ethyJ-p.yridazine-J^-diam.i.ne

40 wt% Aqueous methanamine (10.0 mL, 116 mmol) was added to 3,5-dichloropyridazin-4- amine (0.525 g, 3.20 mmol). The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated to half its original volume, diluted with water, filtered, washed with water, and dried under vacuum to afford 5-chloro- N3-methyl-pyridazine-3, 4-diamine (0.360 g, 71%) as a white solid; 1HNMR (500MHz,

DMSO-d6) 2.91 (3H, d), 6.09 (2H, br s), 6.23 (1H, br d), 8.12 (1H, s); m/z: (ES+), [M+H] 159.0 _. (b) _. 4 _, -Chl pro-7 -methyl -imidazoX4, 5 -cjpy ;ri dazine

Triethyl orthoformate (10 mL, 60 mmol) was added to 5-chloro-N3-methyl-pyridazine-3,4- diamine (0.333 g, 2.10 mmol). The resulting mixture was stirred at 150 °C for 90 minutes. The reaction was then concentrated. The resulting residue was treated with saturated aqueous sodium bicarbonate, then extracted three times with 5:1 DCM/IPA. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford 4-chloro-7- methyl-imidazo[4,5-c]pyridazine (0.310 g, 88%) as a beige solid; 1H NMR (500MHz,

DMSO-d6) 4.01 (3H, s), 8.84 (1H, s), 9.24 (1H, s). m/z: (ES+), [M+H] = 169.0 {cJ _. S-Methyl-j^^morphpJinoaniJinoj-^-^^ _^ S.S-tetramethyJ-j.^^-dioxabprolan:^- yljpyrazine-2 _: carbpxamide

1,4-Dioxane (1.0 mL) was added to a mixture of bis(pinacolato)diboron (0.031 g, 0.12 mmol), 6-bromo-5-methyl-3-(4-morpholinoanilino)pyrazine-2-carboxami de (0.040 g, 0.10 mmol), PdCh(dppf) (7.5 mg, 0.01 mmol) and potassium acetate (0.020 g, 0.20 mmol). The resulting mixture was evacuated and backfilled with nitrogen, then stirred at 80 °C for 4 hours. The reaction mixture was then allowed to cool to room temperature and used directly in the next step, assuming 100% yield.

{¾ _. 5rMethyl-6-(7 _: methyhmidazp^4 ₁ 5-c]pyridazin-4 _: yl) _: 3-(4-mpiphplinpanilinpJpyrazine-2 _: carboxamide

MeOH (1.0 mL) was added to a mixture of 4-chloro-7-methyl-imidazo[4,5-c]pyridazine (0.034 g, 0.20 mmol), PdCb(dppf) (7.3 mg, 0.010 mmol) and potassium phosphate (0.042 g, 0.20 mmol). The borylation reaction mixture from the previous step was added to the vial via syringe. The vial was evacuated and backfilled with nitrogen. The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction mixture was then diluted with water, filtered, and dried under vacuum. The resulting solid was purified twice by silica gel chromatography, each time using 0-10% MeOH-DCM as eluent, to afford 5-methyl- 6-(7-methylimidazo[4,5-c]pyridazin-4-yl)-3-(4-morpholinoanil ino)pyrazine-2-carboxamide (0.013 g, 29%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 3.01 - 3.12 (4H, m), 3.64 -

9.41 (1H, s), 11.17 (1H, s); the pyrazine methyl group signal was buried under the DMSO peak; m/z: (ES+), [M+H] = 446.4

Example 45 5-(Methylamino)-6-(7-methylimidazor4.5-clpyridazin-4-vD-3-(4 - morpholinoanilino)pyrazine-2-carboxamide {a) _. 6:Chlpro-5-(methylaminp)-3-(4 _: morphplinoanilino)p _. yrazine-2-carbgxamide 7 N Methanolic (10 mL, 70 mmol) was added to methyl 6-chloro-5-(methylamino)-3-(4- morpholinoanilino)pyrazine-2-carboxylate (1.86 g, 4.92 mmol). The resulting mixture was stirred at 80 °C for 4 days in a Biotage microwave reactor. The reaction was then allowed to cool to room temperature and filtered. The resulting precipitate was collected and washed with MeOH, then dried under vacuum to afford 6-chloro-5-(methylamino)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (1.576 g, 88% yield) as a yellow solid. 1HNMR (500MHz, DMSO-d6) d 2.91 (3H, d), 3.01 - 3.07 (4H, m), 3.69 - 3.74 (4H, m), 6.91 (2H, d), 7.29 (1H, br s), 7.48 - 7.58 (4H, m), 11.16 (1H, s). m/z: (ES+), [M+H] = 363.1 {b) _. 5rXMeth _j Jaminp) _: 6_-(_7_-methylimidazp[4 _: 5_-cJp _j ridazin-4 _: y_l_)-3-(_4- mp _.i phplinoanilinp)pyrazine-2-carbpxamide

4-Chloro-7-methyl-imidazo[4,5-c]pyridazine (0.035 g, 0.21 mmol), bis(pinacolato)diboron (0.072 g, 0.28 mmol), potassium acetate (0.062 g, 0.63 mmol), cataCXium A Pd G3 (0.015 g, 0.020 mmol), and cataCXium A (7.5 mg, 0.020 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.0 mL) was added. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then allowed to cool to room temperature and set aside.

6-chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (0.050 g, 0.14 mmol), Pd(dppf)Ch DCM adduct (10 mg, 0.01 mmol), and cesium fluoride (0.063 g, 0.41 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resuliting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was allowed to cool to room temperature, then treated with saturated aqueous sodium bicarbonate. The resulting precipitate was filtered, washed with water, and dried under vacuum. The resulting solid was purified twice by silica gel chromatography, using 0-10% MeOH in DCM as eluent each time. The resulting residue was purified further by Cl 8 reverse phase chromatography, using 0- 60% MeCN-HiO as eluent and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(7- methylimidazo[4,5-c]pyridazin-4-yl)-3-(4-morpholinoanilino)p yrazine-2-carboxamide (3.0 mg, 4.7%) as an orange solid; 1HNMR (500 MHz, DMSO-d6) 3.03 (3H, d), 3.05 - 3.09 (4H, m), 3.70 - 3.76 (4H, m), 4.03 (3H, s), 6.96 (2H, d), 7.46 (1H, s), 7.67 (2H, d), 8.09 (1H, s), 8.82 (1H, s), 9.72 (1H, q), 9.87 (1H, s), 11.52 (1H, s); m/z: (ES+), [M+H]+ = 461. Example 46

6-(3-Ethylimidazor4.5-c1pyridin-7-vD-5-(rnethylarnino)-3- (4-morpholinoanilino)pyrazine-2- carboxamide .(ad _. Zr _. Br _. o _. ino-S-ethyl-imidazoL^S-cJpyridine

1,1 -Diethoxy -N,N-dimethyl-methanamine (7.43 g, 50.5 mmol) was added to a solution of 7- bromo-3H-imidazo[4,5-c]pyridine (2.00 g, 10.1 mmol) in DMF (30 mL). The resulting mixture was stirred at 80 °C for 4 hours. The resulting residue was purified by C18 reverse phase chromatography, using 0-60% MeCN-4:l MeOH/water as eluent and 0.1% ammonium bicarbonate as modifier, to afford 7-bromo-3-ethyl-imidazo[4,5-c]pyridine (800 mg, 35%) as a white solid; 1H NMR (400 MHz, DMSO-d6) d 1.44 (3H, t), 4.38 (2H, q), 8.46 (1H, s), 8.57 (1H, s), 9.00 (1H, s); m/r. (ES+), [M+2+H]+ = 228.1

{b).Methyl.3-aming-6-Q-ethylimidazo[4 _: 5-cJp _j ridin _: 7-yl)-5 _: (methylaminoJpyrazine-2 _: carbpxylate CataCXium A Pd G2 (236 mg, 0.350 mmol) was added to a mixture of cataCXium A tetrafluorob orate (158 mg, 0.350 mmol), 7-bromo-3-ethyl-imidazo[4,5-c]pyridine (400 mg, 1.77 mmol), bis(pinacolato)diboron (1.35 g, 5.31 mmol), and potassium acetate (521 mg, 5.31 mmol) in DMF (16 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then allowed to cool to room temperature and set aside. Methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (383 mg, 1.77 mmol), cesium fluoride (806 mg, 5.31 mmol), and PdCh(dppf) (194 mg, 0.27 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 2 hours. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-amino-6-(3-ethylimidazo[4,5-c]pyridin-7-yl)-5- (methylamino)pyrazine-2-carboxylate (0.207 g, 36%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.50 (3H, t), 2.83 (3H, d), 3.74 (3H, s), 4.44 (2H, q), 7.26 (2H, br s), 7.49 (1H, br q), 8.45 (1H, s), 8.53 (1H, s), 9.06 (1H, s). m/z\ (ES+), [M+H]+ = 328.1 _. (cJ _. Methyl 6-(3 _r ethylirnidazob4,5-c]pyridin-7:yJJ:5- _. (rnethyJamino)-3 ₇ (4 _: Plorphqlinoanilinq)pyrazine-2-carboxylate

Brettphos Pd G3 (55 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-6-(3- ethylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazine-2-c arboxylate (100 mg, 0.31 mmol), 4-(4-bromophenyl)morpholine (74 mg, 0.31 mmol), and cesium carbonate (299 mg, 0.920 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 6-(3- ethylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-(4-morpho linoanilino)pyrazine-2- carboxylate (0.107 g, 72%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) 5 1.51 (3H, t), 2.90 (3H, d), 3.04 - 3.12 (4H, m), 3.71 - 3.78 (4H, m), 3.82 (3H, s), 4.45 (2H, q), 6.97 (2H, d), 7.67 (2H, d), 7.89 (1H, br q), 8.52 (1H, s), 8.56 (1H, s), 9.08 (1H, s), 10.26 (1H, s). m/z\ (ES+), [M+H]+ = 489.4

_. (d _. ) _. 6 _.-. (3-Ethylimidazo[4 _J 5-c]pyridin-7-yl) _. :5-(methylamino)-3:(4-mprpholinpanilino)pyrazine:

2.-.carbQxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 6-(3-ethylimidazo[4,5- c]pyridin-7-yl)-5-(methylamino)-3-(4-morpholinoanilino)pyraz ine-2-carboxylate (92 mg, 0.19 mmol). The resulting suspension was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures of MeCN- H2O as eluent, and 0.1% formic acid as modifier, to afford 6-(3-ethylimidazo[4,5-c]pyridin-7- yl)-5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2-carbox amide (20 mg, 22%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.51 (3H, t), 2.93 (3H, d), 3.07 (4H, t), 3.74 (4H, t), 4.45 (2H, q), 6.95 (2H, d), 7.30 (1H, s), 7.66 (2H, d), 7.69 (1H, s), 7.96 (1H, br q),

8.58 (1H, s), 8.70 (1H, s), 9.06 (1H, s), 11.29 (1H, s); m/z\ (ES+), [M+H]+ = 474.2

Example 47

6-(3-Cvclopropylimidazor4.5-clpyridin-7-vn-5-(methylamino )-3-(4- morpholinoanilino)pyrazine-2-carboxamide

{a)7:BromQ:3rCycloprppyl _: imidazo[4 _: 5-cJp _. yridine

Copper (II) acetate (0.532 g, 2.93 mmol) and 2,2'-bipyridine (0.457 g, 2.93 mmol) were added to a mixture of cyclopropylboronic acid (0.55 g, 6.4 mmol), 7-bromo-3H-imidazo[4,5- cjpyridine (0.580 g, 2.93 mmol), and sodium carbonate (0.621 g, 5.86 mmol) in DCE (15 mL). The resulting mixture was stirred at 70 °C for 23 hours. The reaction was then allowed to cool to room temperature, treated with saturated aqueous ammonium chloride, and extracted with DCM. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent, to afford a mixture of 2 regio-isomers. The isomers were separated by preparative HPLC, using a 5 micron, 30 mm x 100 mm XSelect CSH C18 OBD column, 20- 40% MeCN-ThO as eluent, and 0.1% ammonium hydroxide as modifier, to afford 7-bromo-3- cyclopropyl-imidazo[4,5-c]pyridine (0.085 g, 12%). 1HNMR (500MHz, DMSO-d6) 1.07 - 1.18 (4H, m), 3.61 - 3.71 (1H, m), 8.50 (1H, s), 8.56 (1H, s), 8.97 (1H, s); m/z: (ES+),

[M+H]+ = 237.6

{b) _. 6 _. -(3-Cyclppropylimidazp[4,5_-c]pyridin-7-yl)-5-(methyla minp)-3-(4- mpiphplinp^ilinp)pyrazine-2-carboxamide

A mixture of 7-bromo-3-cyclopropyl-3H-imidazo[4,5-c]pyridine (0.050 g, 0.21 mmol), bis(pinacolato)diboron (0.080 g, 0.32 mmol), potassium acetate (0.062 g, 0.63 mmol), cataCXium A Pd G3 (0.015 g, 0.020 mmol), and cataCXium A (7.5 mg, 0.020 mmol) in DMF (2.0 mL) was evacuated and backfilled three times with nitrogen. The reaction mixture was stirred at 100 °C for 18.5 hours. The reaction was then allowed to cool to room temperature and set aside.

6-chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (0.050 g, 0.14 mmol), PdCh(dppf) (10 mg, 0.01 mmol), and cesium fluoride (0.063 g, 0.41 mmol) were combined in a microwave vial, which was evacuated and backfilled with nitrogen three times. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent. The resulting material was further purified by Cl 8 chromatography, using 10-40% MeCN-water as eluent, and 0.2% ammonium hydroxide as modifier. The resulting material was further purified by C18 chromatography, using 0-30% MeCN-FfO as eluent, and 0.1% formic acid as modifier, to afford 6-(3-cyclopropylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)- 3-(4- morpholinoanilino)pyrazine-2-carboxamide (10 mg, 15%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) d 1.08 - 1.22 (4H, m), 2.91 (3H, d), 3.01 - 3.09 (4H, m), 3.66 - 3.71

(1H, m), 3.71 - 3.75 (4H, m), 6.94 (2H, d), 7.29 (1H, br s), 7.65 (2H, d), 7.67 (1H, br s), 7.84 (1H, br q), 8.55 (1H, s), 8.71 (1H, s), 9.02 (1H, s), 11.28 (1H, s); m/z: (ES+), [M+H]+ = 486.2

Example 48

6-r3-(Difluoromethvnimidazor4.5-c1pyridin-7-yl1-5-(methyl amino)-3-(4- morpholinoanilino)pyrazine-2-carboxamide

£a)..7:Bromo _: _3_-(_d_ifluprqmethyj)_irni_d_azo[_4,5-c]pyridi_n_e l-[[Bromo(difluoro)methyl]-ethoxy-phosphoryl]oxyethane (0.731 mL, 4.11 mmol) was added to a solution of 7-bromo-3H-imidazo[4,5-c]pyridine (0.543 g, 2.74 mmol) and potassium hydroxide (0.923 g, 16.5 mmol) in acetonitrile (8.0 mL) and water (8.0 mL). The resulting mixture was stirred at room temperature for 1 hour. The reaction was then extracted with 2- methyltetrahydrofuran. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 15% MeOH-DCM as eluent. The resulting material was further purified by chiral SFC, using a 5 micron, 4.6 x 100 mm ChiralPak OD column, using isocratic 20% MeOH-sC0 ₂ as eluent, and 0.2% ammonium hydroxide as modifier, to afford 7-bromo-3-(difluoromethyl)-3H- imidazo[4,5-c]pyridine (0.050 g, 7.4% yield) as a yellow solid. 1HNMR (500MHz, DMSO- d6) 8.17 (1H, t), 8.67 (1H, s), 8.94 (1H, s), 9.06 (1H, s). m/z : (ES+), [M+H]+ = 247.9 {b) _. 6-[3-(DiflupromethylJimidazo[4 _: 5-cJp _j ridin _: 7-yl]-5 _: (methylaminc))-3-(4- mpiphplinp^iHnp)pyrazine-2-carboxamide

A mixture of bis(pinacolato)diboron (0.070 g, 0.28 mmol), 6-chloro-5-(methylamino)-3-(4- morpholinoanilino)pyrazine-2-carboxamide (0.067 g, 0.18 mmol), PdCh(dppf) (0.014 g, 0.020 mmol), and potassium acetate (0.054 g, 0.55 mmol) in 1,4-dioxane (2.0 mL) was degassed and purged with nitrogen. The resulting mixture was heated at 80 °C for 2 hours. The reaction was then allowed to cool to room temperature. A solution of 7-bromo-3- (difluoromethyl)imidazo[4,5-c]pyridine (0.046 g, 0.19 mmol) in dioxane (1.5 mL) and 2 M aqueous potassium phosphate (0.277 mL, 0.554 mmol) was added. The resulting mixture was degassed, purged with nitrogen, and stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was diluted with water. The resulting precipitate was collected and washed with water and dried under vacuum. The resulting solid was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent. The resulting material was further purified by reverse phase Cl 8 chromatography, using 0 to 30% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 6-[3-(difluoromethyl)imidazo[4,5- c]pyridin-7-yl]-5-(methylamino)-3-(4-morpholinoanilino)pyraz ine-2-carboxamide (0.030 g, 33% yield) as an orange solid. 1H NMR (500MHz, DMSO-d6) d 2.87 (3H, d), 3.01 - 3.12 (4H, m), 3.70 - 3.77 (4H, m), 6.96 (2H, br d), 7.12 (1H, br s), 7.28 (1H, br s), 7.58 - 7.72 (3H, m), 8.23 (1H, t), 8.75 (1H, s), 8.92 (1H, s), 9.14 (1H, s), 11.31 (1H, s). 19F NMR (471 MHz, DMSO-d6) -94.27. m/r. (ES+), [M+H]+ = 495.9

Example 49

6-(7-Chloro-l-m ethyl -benzimidazol-4-vn-5-(methylamino)-3-(4-morpholinoanilino)py razine-

2-carboxamide A mixture of 3 -bromo-6-chloro-benzene- 1,2-diamine (1.18 g, 5.32 mmol) and formic acid (10 mL, 260 mmol) was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was treated with saturated aqueous sodium bicarbonate. The resulting precipitate was collected via filtration, washed with water, and dried under vacuum to afford 4-bromo-7-chloro-lH-benzimidazole (1.188 g, 96%) as a beige solid; 1HNMR (500 MHz, DMSO-d6) 7.24 (1H, br d), 7.42 (1H, dd), 8.39 (1H, s), 13.28 (1H, br s); m/z: (ES+), [M+H]+ = 231.0

{¾ _. 4rBromQ-7-chlo _. rp:l -methyl-benzimidazole

60 wt% Sodium hydride in oil (0.246 g, 6.16 mmol) was added to a solution of 4-bromo-7- chloro-lH-benzimidazole (1.188 g, 5.130 mmol) in DMF (20 mL) at 0 °C. The reaction mixture was stirred at 25 C for 35 minutes. Iodomethane (0.353 mL, 5.65 mmol) was added. The reaction mixture was stirred at 25 C for 90 minutes. The reaction was then quenched with water at 0 °C. The resulting precipitate was collected by filtration and washed with water. The resulting solid was purified further by preparative SFC, using a 5 micron, 21 mm x 250 mm Lux amylose 2 column and 12% EtOH-sCCh as eluent, to afford 4-bromo-7-chloro-l -methyl- benzimidazole (0.198 g, 16%); 1HNMR (500 MHz, DMSO-d6) 4.08 (3H, s), 7.22 (1H, d), 7.42 (1H, d), 8.33 (1H, s); m/z: (ES+), [M+H]+ = 245.0 (c) XT _. -Chl oro-l _: methy 1 -b enzimi dazol -4 _: y _. Qbpronic ; _. aci d

A mixture of bis(pinacolato)diboron (0.159 g, 0.630 mmol), 4-bromo-7-chloro-l-methyl- benzimidazole (0.077 g, 0.31 mmol), Pd(dppf)Ch (0.023 g, 0.030 mmol), and potassium acetate (0.092 g, 0.94 mmol) in 1,4-dioxane (2.0 mL) was sparged with nitrogen. The resulting mixture was heated at 100 °C for 40 hours. The reaction mixture was filtered through Celite and washed with EtOAc. The filtrate was concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-15% MeCN-H?0 as eluent and 0.1% formic acid as modifier, to afford (7-chloro-l-methyl-benzimidazol-4-yl)boronic acid (0.023 g, 35%) as a white solid; 1HNMR (500 MHz, DMSO-d6) 4.11 (3H, s), 7.31 (1H, d), 7.59 (1H, d), 8.40 (1H, s), 8.63 (2H, s); m/z: (ES+), [M+H]+ = 211.0 {¾ _. 6rX7-Chloro:i-methyl-benzimidazgl-4 _: yl) _: 5-(methylaming)-3-(4 _: moiphglino^iHng)pyrazine-2-carbgxamide

(7-Chloro-l-methyl-benzimidazol-4-yl)boronic acid (0.037 g, 0.18 mmol), 6-chloro-5- (methylamino)-3-(4-morpholinoanilino)pyrazine-2-carboxamide (0.050 g, 0.14 mmol), Pd(dppf)Ch (10 mg, 0.010 mmol), and cesium fluoride (0.063 g, 0.41 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. MeOH (2.0 mL) was added. The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then allowed to cool to room temperature and diluted with water. The resulting precipitate was collected via filtration, washed with water, and dried under vacuum. The resulting solid was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent. The resulting residue was further purified by Cl 8 reverse phase chromatography, using 10-60% MeCN-FbO as eluent and 0.2% NH4OH as modifier, to afford 6-(7-chloro-l-methyl-benzimidazol-4-yl)-5-(methylamino)-3-(4 -morpholinoanilino)pyrazine- 2-carboxamide (10 mg, 15%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.87 (3H, d), 3.00 - 3.11 (4H, m), 3.67 - 3.79 (4H, m), 4.13 (3H, s), 6.93 (2H, br d), 7.26 (1H, br s), 7.37 (1H, d), 7.43 (1H, br q), 7.47 (1H, d), 7.55 (1H, br s), 7.64 (2H, br d), 8.32 (1H, s), 11.23 (1H, s); m/z: (ES+), [M+H]+ = 493.1

Example 50 6-(7-Cvano-l-methyl-benzimidazol-4-vD-5-( ^' methylamino)-3-(4-morpholinoanilino)pyrazine-

2-carboxamide

£4) _.. 4:Brqmo-7_-chJ _. oro_-l_H-ben_z_o£d]i_mi_dazoJe

A mixture of 3 -bromo-6-chlorobenzene- 1,2-diamine (1.18 g, 5.32 mmol) and formic acid (10 mL, 260 mmol) was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was treated with saturated aqueous sodium bicarbonate. The resulting precipitate was collected via filtration and washed with water, then dried under air to afford 4- bromo-7-chloro-lH-benzo[d]imidazole (1.19 g, 96% yield) as a beige solid. 1H NMR (500MHz, DMSO-d6) d 7.24 (1H, br d), 7.42 (1H, dd), 8.39 (1H, s), 13.27 (1H, br s). m/z\ (ES+), [M+H]+ = 231.0

{¾ _. 4rBromq-7-chlgro _:. l-methyl-benzimidazole _. and 7-bromo-4:chlo _. ro:l _. -methyl- benzimidazole 60 wt% Sodium hydride in mineral oil (0.246 g, 6.16 mmol) was added to a solution of 4- bromo-7-chloro-lH-benzimidazole (1.19 g, 5.13 mmol) in DMF (20 mL) at 0 °C. The resulting mixture was stirred at 25 °C for 35 minutes. Iodomethane (0.353 mL, 5.65 mmol) was added. The resulting mixture was stirred at 25 °C for 90 minutes. The reaction was then cooled to 0 °C and then quenched with water. The resulting precipitate was collected by filtration, washed with water, and dried under vacuum to afford a mixture of 4-bromo-7- chloro-1 -methyl-benzimidazole and 7-bromo-4-chloro-l -methyl-benzimidazole as a beige soild (1.09 g, 87%); 1HNMR (500MHz, DMSO-d6) d 3.99 - 4.15 (3H, m), 7.12 - 7.30 (1H, m), 7.34 - 7.50 (1H, m), 8.26 - 8.43 (1H, m); m/z\ (ES+), [M+H]+ = 245.0 {c) _. 7 _: Chlpro-3-methyl-benzimidazole-4-carbgnitrile

A mixture of 4-bromo-7-chloro-l-methyl-benzimidazole and 7-bromo-4-chloro-l-methyl- benzimidazole (0.427 g, 1.74 mmol), zinc cyanide (0.204 g, 1.74 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.402 g, 0.350 mmol) in DMF (5 mL) was evacuated and backfilled with nitrogen three times. The reaction mixture was stirred at 90 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent. The resulting mixture of two regio-isomers was separated by preparative HPLC, using a 5 micron, 19 mm x 250 mm XBridge cl 8 column, 20-50% MeCN-FFO as eluent, and 0.2% ammonium hydroxide as modifier, to afford 7-chloro-3-methyl-benzimidazole-4-carbonitrile (0.076 g, 18%). 1HNMR (500MHz, DMSO-d6) d 4.08 (3H, s), 7.47 (1H, d), 7.77 (1H, d), 8.47 (1H, s); m/z\ (ES+),

[M+H]+ = 192.0

£dJ _. 6rf7_-Cy_an_o_-l_:_methyJ_:_b_en_zi_mi_dazoJ-4-yJJ-5-( me_thy_lam)n_o)_ _: _3-(4- moiphplino^iHnp)pyrazine-2-carbgxamide

A mixture of 7-chloro-3-methyl-benzimidazole-4-carbonitrile (0.040 g, 0.21 mmol), bis(pinacolato)diboron (0.080 g, 0.32 mmol), potassium acetate (0.062 g, 0.63 mmol), cataCXium A Pd G3 (0.015 g, 0.020 mmol) and cataCXium A (7.5 mg, 0.020 mmol) in DMF (2.0 mL) was evacuated and backfilled three times with nitrogen. The resulting mixture was stirred at 100 °C for 18.5 hours. The reaction was then allowed to cool to room temperature and was set aside. 6-Chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2-c arboxamide (0.050 g, 0.14 mmol), PdCb(dppf) (10 mg, 0.01 mmol), and cesium fluoride (0.063 g, 0.41 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-5% MeOH-DCM as eluent. The product was further purified by reverse phase Cl 8 flash chromatography, using 0-45% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 6-(7-cyano-l-methyl-benzimidazol-4-yl)- 5-(methylamino)-3-(4-morpholinoanilino)pyrazine-2-carboxamid e (6.0 mg, 9.0%) as a yellow solid. 1H NMR (500MHz, DMSO-d6) d 2.90 (3H, d), 3.02 - 3.09 (4H, m), 3.67 - 3.78 (4H, m), 4.13 (3H, s), 6.60 (1H, br s), 6.94 (2H, d), 7.34 (1H, br s), 7.65 (2H, br d), 7.74 (1H, d),

7.83 (1H, d), 7.89 (1H, br q), 8.49 (1H, s), 11.30 (1H, s). m/z: (ES+), [M+H]+ = 484.2

Example 51

6-(3.4-Dimethylimidazor4.5-c1pyridin-7-vn-5-(methylamino) -3-(4- morpholinoanilino)pyrazine-2-carboxamide iaX5 _r Brqmo-2-methyl-p _. yridine-3 ₃ 4-diamine

2, 5-Dibromopyridine-3, 4-diamine (5.00 g, 18.7 mmol) and bis(triphenylphosphine)palladium(II) chloride (1.32 g, 1.87 mmol) were combined in a multineck flask, which was evacuated and backfilled three times with nitrogen. 1,4-dioxane (10 mL) was added. Dimethylzinc (13 mL, 26 mmol) was added as a 2 M solution in toluene. The reaction was stirred at 80 °C for 60 hours. The reaction was allowed to cool to room temperature, then quenched with water (50 mL), extracted once with EtOAc (30 mL) and twice with 3:1 DCM/IPA (20 mL each). The combined organics were dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using an isocratic mixture of 3:1 EtOAc-EtOH as eluent, to afford 5-bromo- 2-m ethyl-pyridine-3, 4-diamine (0.533 g, 14%) as a brown solid; 1HNMR (500MHz, DMSO- d6) d 2.17 (3H, s), 4.61 (2H, br s), 5.48 (2H, br s), 7.58 (1H, s); m/z: (ES+), [M+H]+ = 202.0 (bJ _. S-Bromo-Nj^^dimethylpyridine _yj ^-diami _. ne 25 wt% Methanolic sodium methoxide (3.80 mL, 16.6 mmol) was added to a suspension of 5- bromo-2-m ethyl-pyridine-3, 4-diamine (818 mg, 4.05 mmol) and paraformaldehyde (182 mg, 6.07 mmol) in MeOH (10 mL). The reaction was stirred at 25 °C for 4 hours. Sodium borohydride (245 mg, 6.48 mmol) was added and the resulting mixture was stirred at 60 °C for 1 hour. The reaction was then concentrated to an off-white sludge, which was suspended in water (20 mL), then extracted with ethyl acetate (4 x 15 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to a brown oil, which was a mixture of several components, including starting material and desired product. This mixture was carried forward to the next step without isolation. (cJ^-Bromo-j _^ d-dimethyLjmidazotd _^ S-cJpyridirie

Triethyl orthoformate (15 mL, 90.1 mmol) was added to crude 5-bromo-N3,2- dimethylpyridine-3, 4-diamine (0.875 g, 4.05 mmol). The resulting suspension was stirred at 145 °C for 40 minutes. The reaction was then concentrated. The resulting brown solid was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford 7- bromo-3,4-dimethyl-imidazo[4,5-c]pyridine (0.126 g, 14%) as a white solid; 1HNMR (500MHz, DMSO-d6) d 2.83 (3H, s), 4.08 (3H, s), 8.26 (1H, s), 8.40 (1H, s); m/z\ (ES+), [M+H]+ = 226.0

{¾ _. 6rX3 _: 4-Dimethylimidazo[4,5-cJpyridin-7 _. -y!)-5: _. (methylamino)-3-0- i??oiThplinoanriino)^razine _: 2-carbgxamide

A mixture of 7-bromo-3,4-dimethyl-imidazo[4,5-c]pyridine (0.050 g, 0.22 mmol), bis(pinacolato)diboron (0.084 g, 0.33 mmol), potassium acetate (0.065 g, 0.66 mmol), cataCXium A Pd G3 (0.016 g, 0.020 mmol) and cataCXium A (7.9 mg, 0.020 mmol) in DMF (2.0 mL) was evacuated and backfilled three times with nitrogen. The reaction mixture was stirred at 100 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

6-Chloro-5-(methylamino)-3-(4-morpholinoanilino)pyrazine- 2-carboxamide (0.050 g, 0.14 mmol), PdCb(dppf) (10 mg, 0.01 mmol), and cesium fluoride (0.063 g, 0.41 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent. The resulting material was further purified by alumina chromatography, using 0-5% MeOH-DCM as eluent. The resulting material was further purified by cl 8 reverse phase chromatography, using 0- 20% MeCN-ThO as eluent and 0.1% formic acid as modifier, to afford 6-(3,4- dimethylimidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-(4-mor pholinoanilino)pyrazine-2- carboxamide (18 mg, 28%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 2.90 (3H, d), 2.93 (3H, s), 3.03 - 3.07 (4H, m), 3.71 - 3.75 (4H, m), 4.14 (3H, s), 6.94 (2H, d), 7.27 (1H, br s), 7.63 (1H, br s), 7.64 (2H, d), 7.79 (1H, br q), 8.40 (1H, s), 8.46 (1H, s), 11.24 (1H, s); m/z: (ES+), [M+H]+ = 474.2

Example 52 3-(2-Fluoro-4-morpholino-anilino)-5-(methylamino)-6-(3-methy limidazor4.5-clpyridin-7-

{4)M9thyJ.J.:amino _: 5-(methylaming)-6 _: (3 _: methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yl_)pyrazine-2 _: carbpxylate A mixture of methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (2.17 g, 10.0 mmol), 2-(3-methylimidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaboroca ne (3.08 g, 12.5 mmol), Pd(dppf)C12 dichloromethane adduct (0.817 g, 1.00 mmol), and cesium fluoride (4.56 g, 30.0 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (91 mL) and water (9.1 mL) were added. The resulting mixture was allowed to stir at 90 °C for 3 hours. The reaction was allowed to cool to room temperature, then cooled to 0 °C, then diluted with wter (100 mL). The resulting precipitate was collected by filtration, rinsed with water and diethyl ether, and dried under vacuum, to afford methyl 3 -amino-5 -(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (3.095 g, 99% yield) as a gray solid. 1H NMR (500 MHz, DMSO-d6) 2.81 (3H, d), 3.73 (3H, s), 3.99 (3H, s), 7.23 (2H, br s), 7.50 (1H, br q), 8.45 (2H, s), 8.99 (1H, s). m/z\ (ES+), [M+H]+ = 314.4

{¾ _. Methyl _. 3-(2-flupro:4-mo^hplino-anilino)-5:(methylamino)-6-(3- rnethylimidazo[4,5- c]pyridin:7 _: yljpyrazine-2 _: carbpxylate Brettphos Pd G3 (23 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (80 mg, 0.26 mmol), 4-(4-bromo-3-fluoro-phenyl)morpholine (66 mg, 0.26 mmol), and cesium carbonate (250 mg, 0.77 mmol) in 1,4-dioxane (6 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-(2- fluoro-4-morpholino-anilino)-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.100 g, 80% yield) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.85 (3H, d), 3.01 - 3.21 (4H, m), 3.62 - 3.86 (7H, m), 4.01 (3H, s), 6.80 (1H, d), 6.89 - 7.03 (1H, m), 7.92 (1H, s), 8.36 (1H, t), 8.45 - 8.58 (2H, m), 9.04 (1H, s), 10.35 (1H, s). m/z·. (ES-), [M-H]- = 491.2

{c) _. 3:{2:Huoro-4 _: morphplinp:anilinoJ-5-(methylarninp)-6-(3-methyhmidazo ^4 ₁ 5-c] _. pyridiri-7- yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-(2-fluoro-4-morpholino- anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 15-35% MeCN/H20 as eluent, and 0.1% formic acid as modifier, to afford 3-(2-fluoro-4-morpholino-anilino)-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (4.3 mg, 5.5%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.92 (3H, d), 3.06 - 3.13 (4H, m), 3.73 (4H, m), 4.01 (3H, s), 6.79 (1H, d), 6.93 (1H, dd), 7.31 (1H, s), 7.71 (1H, s), 8.00 (1H, br q), 8.44 (1H, t), 8.47 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.37 (1H, s). m/z\ (ES+), [M+H]+ = 478.2

Example 53

3-(2.3-Difluoro-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

(a) _. ir^rBjpmo^S-difluorg^henyJJmorpholine

(rac)-BINAP (1.95 g, 3.14 mmol) and palladium(II) acetate (0.704 g, 3.14 mmol) were added to a mixture of l-bromo-2,3-difluoro-4-iodo-benzene (1.00 g, 3.14 mmol), morpholine (0.273 g, 3.14 mmol), and cesium carbonate (1.02 g, 3.14 mmol) in toluene (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by reverse phase Cl 8 chromatography, using 0 to 60% MeCN-water as eluent, and 0.05% formic acid as modifier, to afford 4-(4-bromo-2,3-difluoro- phenyl)morpholine (300 mg, 34% yield) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 2.94 - 3.04 (4H, m), 3.71 - 3.77 (4H, m), 6.95 - 6.99 (1H, m), 7.59 - 7.67 (1H, m). m/z: (ES+), [M+2+H]+ = 280.0

{¾ _. Methyl _. 3-(2,3-dAfluprg-4-mprpholino-anilinp):5-(methylamino)- 6:(3:methylimidazg[ _. 4 _L 5: clpyxidin-7 _: yj)pyraz_i_ne-2 _: _carbgxyja_te

BrettPhos Pd G3 (289 mg, 0.320 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), 4-(4-bromo- 2,3-difluoro-phenyl)morpholine (89 mg, 0.32 mmol), and cesium carbonate (104 mg, 0.320 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 13 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(2,3-difluoro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (0.050 g, 31%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.88 (3H, d), 3.02 (4H, t), 3.76 (4H, t), 3.84 (3H, s), 4.01 (3H, s), 6.91 (1H, t), 7.94 (1H, s), 8.26 (1H, t), 8.51 (2H, d), 9.05 (1H, s), 10.50 (1H, s); m/z: (ES+), [M+H]+ = 511.2 (cJp.ri^p-Djtlugrg^d-mgrphgHng _j anjHngh^lmpXhyjamingJ-b-fj-methyJimidazgfd,^- c]pyridin _: 7 _: yljpyrazine-2 _: carbgxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-(2,3-difluoro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (40 mg, 0.08 mmol). The resulting suspension was stirred at 80 °C for 19 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 19 mm x 250 mm XSelect CSH Prep C18 OBD column, 30-40% MeCN- ThO as eluent, and 0.1% formic acid as modifier, to afford 3-(2,3-difluoro-4-morpholino- anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (3.0 mg, 7.7%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.99 (3H, d), 2.96 - 3.03 (4H, m), 3.72 - 3.80 (4H, m), 4.00 (3H, s), 6.85 - 7.93 (1H, m), 7.39 (1H, s), 7.76 (1H, s), 8.02 (1H, br q) 8.30 - 8.39 (1H, m), 8.50 (1H, s), 8.71 (1H, s), 9.02 (1H, s), 11.63 (1H, s); m/z: (ES+), [M+H]+ = 496.2

Example 54

3-(2-Fluoro-3-methyl-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide _(a) 4:0 _. :Broino:3-flupro:2-rnethyl-phenyl)morpholine

Pd(OAc)2 (0.071 g, 0.32 mmol) was added to a mixture of l-bromo-2-fluoro-4-iodo-3- methyl-benzene (1.00 g, 3.18 mmol), morpholine (0.553 g, 6.35 mmol), rac-BINAP (0.198 g, 0.320 mmol), and potassium tert-butoxide (1.07 g, 9.53 mmol) in toluene (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% EtOH-DCM as eluent, to afford 4-(4-bromo-3-fluoro-2-methyl-phenyl)morpholine (0.300 g, 35%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) 52.19 (3H, dd), 2.80 - 2.87 (4H, m), 3.66 - 3.77 (4H, m), 6.84 (1H, dd), 7.46 (1H, t); m/z: (ES+), [M+H]+ = 274. {b).Methyl.3-(2-flupro _: 3-methyl-4-mo^)holino-anilino) _: 5-(methylamino)-6 _: (3 _: methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carboxylate

BrettPhos Pd G3 (376 mg, 0.410 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (130 mg, 0.41 mmol), 4-(4-bromo- 3-fluoro-2-methyl-phenyl)morpholine (114 mg, 0.410 mmol), and cesium carbonate (135 mg, 0.410 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 13 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(2-fluoro- 3-methyl-4-morpholino-anilino)-5-(methylamino)-6-(3-methylim idazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (0.090 g, 43%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.25 (3H, s), 2.82 - 2.88 (4H, m), 2.93 (3H, d), 3.73 - 3.77 (4H, m), 3.84 (3H, s), 4.02 (3H, s), 6.93 (1H, d), 7.84 - 8.04 (1H, m), 8.44 - 8.48 (1H, m), 8.50 (1H, s), 8.54 (1H, s), 9.06 (1H, s), 10.60 (1H, s); m/z: (ES+), [M+H]+ = 507.3 {cj.S-Q^Fluoro-S^methyrifl-morphohng-anilino^-S^methylaminpJ -e-Q-methylimidazot^S- c]pyridin-7 _: ylJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-(2-fluoro-3-methyl-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (50 mg, 0.10 mmol). The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Sunfire prep C18 column, 20-30% MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-(2-fluoro-3-methyl-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (20 mg, 40%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.23 (3H, d), 2.83 (4H, t), 2.95 (3H, d), 3.74 (4H, t), 4.01 (3H, s), 6.90 (1H, d), 7.38 (1H, s), 7.75 (1H, s), 8.00 (1H, br q), 8.47 - 8.56

(2H, m), 8.73 (1H, s), 9.03 (1H, s), 11.62 (1H, d); m/z: (ES+), [M+H]+ = 492.2

Example 55

3-(3-Chloro-2-fluoro-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazor4.5- {a)M?thyJ.J.:X3:chloro-2-fluoro _: 4-mpipholino-anilino) _: 5-(methylamino)-6 _: i_3- JI ¹ ethyl.i m j dazo^ _^ S _: _c]pyri din- 7 _: yjjpy razjn e-2 _: carb oxyjate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-(4-bromo-2-chloro-3-fluoro-phenyl)morpholine (94 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 12 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent to afford methyl 3-(3-chloro-2-fluoro-4-morpholino-anilino)-5-(methylamino)-6 -(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.060 g, 36%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) d 2.90 (3H, d), 2.99 (4H, t), 3.72 - 3.79 (4H, m), 3.84 (3H, s), 4.01 (3H, s), 7.06 (1H, dd), 7.97 (1H, br q), 8.44 - 8.56 (3H, m), 9.05 (1H, s), 10.56 (1H, d); m/z: (ES+), [M+H]+ = 527.2

{b).3rX3-Chloro-2-flupro-4-mprpholinp-anilinp) _: 5-(methylamino)-6 _: (3 _: methylimidazg[.4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-(3-chloro-2-fluoro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (60 mg, 0.11 mmol). The resulting suspension was stirred at 80 °C for 18 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm, Xselect CSH OBD column, 22-38% MeCN-ftO as eluent, and 0.1% formic acid as a modifier, to afford 3-(3-chloro-2-fluoro-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (34 mg, 58%) as a yellow solid; 1H NMR (300 MHz DMSO-d6) d 2.91 - 3.03 (7H, m), 3.76 (4H, d), 4.02 (3H, s), 7.06 (1H, d), 7.45 (1H, s), 7.81 (1H, s), 8.02 (1H, br q), 8.53 (1H, s), 8.63 (1H, t),

8.73 (1H, s), 9.05 (1H, s), 11.74 (1H, d); m/z: (ES+), [M+H]+ = 512.2

Example 56

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-( 2.3.5-trifluoro-4-morpholino- anilino)pyrazine-2-carboxamide

.flrii-^.^-Trifluorp^fl-nitro-phenylimoipholine l,2,3,4-Tetrafluoro-5-nitrobenzene (1.00 g, 5.13 mmol) was added to a solution of DIPEA (0.179 mL, 1.03 mmol), morpholine (0.0890 g, 1.03 mmol) in acetonitrile (10 mL). The resulting mixture was stirred at room temperatre for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-5% DCM-(1:10 EtOAc/petroleum ether) as eluent, to afford 4-(2,3,6-trifluoro-4-nitro- phenyl)morpholine (0.200 g, 15%) as a yellow solid. 1H NMR (DMSO, 300 MHz) d 3.36 - 3.43 (4H, m), 3.67 - 3.76 (4H, m), 7.91-8.03 (1H, m); m/r (ES+), [M+H]+ = 263.1 (bJ _^ ^j^-Tritluorp-AmorphojinoanjJine

4-(2,3,6-Trifluoro-4-nitro-phenyl)morpholine (100 mg, 0.38 mmol) was added to tin(II) chloride (289 mg, 1.53 mmol) in ethanol (10 mL). The resulting mixture was stirred at 60°C for 2 hours. The reaction was then concentrated. The resulting residue was redissolved in ethyl acetate (100 mL) and washed three times with saturated aqueous sodium bicarbonate (100 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford 2,3,5-trifluoro-4-morpholinoaniline (0.080 g, 90%) as a solid. 1HNMR (DMSO, 400 MHz) d 2.88-3.00 (4H, m), 3.58 - 3.68 (4H, m), 5.54 (2H, s), 6.30-6.38 (1H, m); m/r (ES+), [M+H]+ = 233.1

(c) _4-(4:B rom 0:2,3 _^ 6-tritl uoroph eny 1 )jm orph ol i n e

2,3,5-Trifluoro-4-morpholinoaniline (70 mg, 0.30 mmol) was added to a mixture of bromotrimethylsilane (0.059 mL, 0.45 mmol), tert-butyl nitrite (47 mg, 0.45 mmol) in dibromomethane (1.00 mL, 14.3 mmol) under nitrogen. The resulting mixture was stirred at 25 C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% EtOAc-petroleum ether as eluent, to afford 4-(4- bromo-2,3,6-trifluorophenyl)morpholine (0.060 g, 67%) as a yellow solid. 1H NMR (DMSO, 300 MHz) d 3.10-3.20 (4H, m), 3.64 - 3.75 (4H, m), 7.53-7.63 (1H, m); m/r (ES+), [M+H]+ = 296.0 {¾.Methyl.5-(methyl^ino)-6 _: 0 _: methyHmkdazp£4 ₁ 5 _: c]pyridin-7 _: yl) _: 3-(2 _J 3 _Jt 5-trifluoro:4- mo¾hplinp-anilinoJpyr^ine-2 _: carbpxylate

4-(4-Bromo-2,3,6-trifluorophenyl)morpholine (60 mg, 0.20 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (64 mg, 0.20 mmol), cesium carbonate (198 mg, 0.610 mmol), and BrettPhos Pd G3 (18.4 mg, 0.0200 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(2, 3,5-trifluoro-4- morpholino-anilino)pyrazine-2-carboxylate (0.060 g, 56%) as a yellow solid; 1H NMR (DMSO, 300 MHz) d 2.93 (3H, d), 3.05-3.18 (4H, m), 3.66-3.74 (4H, s), 3.85 (3H, s), 4.03 (3H, s), 8.06 (1H, br q), 8.38-8.46 (1H, m), 8.49-8.57 (2H, m), 9.08 (1H, s), 10.78 (1H, s); m/r (ES+), [M+H]+ = 529.3

£9)..5:(M.9.thylaminp)-0_(3 -methyl imj_daz_o£4 ₁ 5-cdpyjidj_n-_7_-yJJ-3-(03_,5_ _: tritl_uoro _: _4-rnp_rphqlin_o_- andinpjpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(2,3,5-trifluoro-4-morph olino-anilino)pyrazine-2- carboxylate (60 mg, 0.11 mmol). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, decreasingly polar mixtures ofMeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(2,3,5-trifluoro-4-morph olino-anilino)pyrazine-2- carboxamide (14 mg, 24%) as a yellow solid; 1H NMR (DMSO, 300 MHz) d 2.96 (3H, d), 3.06-3.16 (4H, m), 3.66-3.76 (4H, m), 4.02 (3H, s), 7.50 (1H, s), 7.85 (1H, s), 8.10 (1H, br q), 8.42 - 8.52 (1H, m), 8.54 (1H, s), 8.73 (1H, s), 9.05 (1H, s), 11.99 (1H, s); m/r (ES+), [M+H]+ = 514.4

Example 57

3-(2-Fluoro-5-methyl-4-morpholino-anilino)-5-(methylamino )-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide

{aX4:0.:Bjpmo:5-flupro-2-methyl-_pheny.l)morphpline l-Bromo-2-fluoro-4-iodo-5-methyl-benzene (500 mg, 1.59 mmol) was added to a mixture of morpholine (138 mg, 1.59 mmol), cesium carbonate (1.55 g, 4.76 mmol) and Xantphos Pd G3 (151 mg, 0.16 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm, XBridge Prep C18 OBD column, decreasingly polar mixtures of MeCN-ThO as eluent, and 0.1% ammonium bicarbonate as modifier, to afford 4-(4-bromo-5-fluoro-2-methyl-phenyl)morpholine (0.160 g, 37%) as a red solid; 1H NMR (DMSO, 300 MHz) d 2.22 (3H, s), 2.79 - 2.88 (4H, m), 3.68 - 3.78 (4H, m), 7.01 (1H, d), 7.48 (1H, d); m/z: (ES+), [M+H]+ = 274.0 {0 _. Methyl _. 3-(2-flupro:5-methyl-4-mo^)holino-anilino):5-(methylam ino)-6:(3: methyhmMazp[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carboxylate

4-(4-Bromo-5-fluoro-2-methylphenyl)morpholine (150 mg, 0.55 mmol) was added to methyl 3-amino-6-(3-m ethyl -3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazine-2-ca rboxylate (171 mg, 0.550 mmol), cesium carbonate (535 mg, 1.64 mmol) and BrettPhos Pd G3 (50 mg, 0.05 mmol) in 1,4-dioxane (1 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(2-fluoro-5- methyl-4-morpholino-anilino)-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (0.150 g, 54%) as a yellow solid; 1H NMR (DMSO, 300 MHz) d 2.27 (3H, s), 2.79 - 2.87 (4H, m), 2.94 (3H, d), 3.69-3.78 (4H, m), 3.84 (3H, s), 4.02 (3H, s), 7.03 (1H, d), 8.01 (1H, br q), 8.44-8.58 (3H, m), 9.05 (1H, s), 10.50 (1H, d); m/z\ (ES+),

[M+H]+ = 507.3

{cj _. Sr^rHuprp-S^methyEd-mprphphnp-anilinp^-S^methylaminpJ- e-Q-rnethylimidazpt^S- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-(2-fluoro-5-methyl-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (100 mg, 0.20 mmol). The resulting mixture was stirred at 80 °C for 16 hours.

The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-(2-fluoro-5-methyl-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxamide (21 mg, 22%) as a yellow solid; 1H NMR (DMSO, 300 MHz) d 2.27 (3H, s),

2.78-2.86 (4H, m), 2.98 (3H, d), 3.70 - 3.79 (4H, m), 4.02 (3H, s), 7.01 (1H, d), 7.36 (1H, s), 7.76 (1H, s), 8.07 (1H, br q), 8.53 (1H, s), 8.61 (1H, d), 8.74 (1H, s), 9.03 (1H, s), 11.52 (1H, d); m/z: (ES+), [M+H]+ = 492.2

Example 58

3-(3.5-Difluoro-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

(a) _. Methyl J _. rfj^-ditluoroyd-morpholinp-anilinof-SrfmethylaminpJ-b- fj-rriethylimidazob^S- e]pyridin-7 _: yllpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (23 mg, 0.030 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 0.26 mmol), 4-(4-bromo- 2,6-difluoro-phenyl)morpholine (142 mg, 0.51 mmol), and cesium carbonate (250 mg, 0.77 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(3,5-difluoro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (0.060 g, 46%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.93 (3H, d),

9.10 (1H, s), 10.49 (1H, s); m/z: (ES+), [M+H]+ = 511.3

£bJ.3-(3 _J _5-Di_tl_uorp _: _4-mp_rp_hplin_o-aniJ_in_o)-5-(met_hyJ_ami_np)-6_:(_3- m_et_hyJjrni_d_azp[_4 _J 5- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide 7 N Methanolic ammonia (1.50 mL, 10.5 mmol) was added to methyl 3-(3,5-difluoro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (55 mg, 0.11 mmol). The resulting suspension was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Sunfire prep C18 column, 20-32% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-(3,5-difluoro-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (14 mg, 26%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.96 (3H, d), 3.07 (4H, m), 3.69 (4H, m), 4.02 (3H, s), 7.46 (1H, s), 7.58 (1H, s), 7.59 (1H, s) 7.81 (1H, s), 8.07 (1H, br q), 8.53 (1H, s), 8.73 (1H, s), 9.04 (1H, s), 11.69 (1H, s); m/z (ES+), [M+H]+ = 496.2

Example 59

3-(3-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(l-me thylbenzimidazol-4-vnpyrazine-

N-Chlorosuccinimide (66 mg, 0.49 mmol) was added to a suspension of methyl 3-(3-chloro- 4-morpholino-anilino)-5-(methylamino)-6-(l-methylbenzimidazo l-4-yl)pyrazine-2- carboxylate (150 mg, 0.33 mmol) in MeCN (2 mL). The reaction was stirred at 82 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-5% MeOH-DCM as eluent and 0-0.5% ammonia as modifier, to afford a yellow solid. This solid was dissolved in DCM (20 mL) and washed three times with saturated aqueous sodium bicarbonate (10 mL each). The organic layer was then dried over magnesium sulfate, filtered, and concentrated to afford 3-(3-chloro-4-morpholino-anilino)-5- (methylamino)-6-(l-methylbenzimidazol-4-yl)pyrazine-2-carbox amide (57 mg, 35%) as a yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.89 - 2.95 (4H, m), 2.96 (3H, d), 3.65 - 3.80 (4H, m), 3.90 (3H, s), 7.15 (1H, d), 7.34 - 7.43 (2H, m), 7.46 (1H, dd), 7.58 - 7.71 (3H, m), 8.18 - 8.29 (2H, m), 8.34 (1H, s), 11.46 (1H, s; m/z: (ES+), [M+H]+ = 493.4 Example 60

3-(3-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(3-me thylimidazor4.5-c1pyridin-7-

Acetonitrile (2 mL) was added to a mixture of 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamid e (42 mg, 0.090 mmol) andN- chlorosuccinimide (34 mg, 0.25 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting orange-brown solid was taken up in 3:1 chloroform/IPA (20 mL) and washed three times with saturated aqueous sodium bicarbonate (20 mL each). The organic layer was dried over sodium sulfate, filtered, and loaded onto celite, then purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford 3-(3-chloro-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (14 mg, 31%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.89 - 2.99 (7H, m), 3.70 - 3.78 (4H, m), 4.00 (3H, s), 7.16 (1H, d), 7.39 (1H, br s), 7.47 (1H, dd), 7.76 (1H, br s), 8.00 - 8.13 (1H, m), 8.25 (1H, d), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.52 (1H, s); m/z: (ES+), [M+H]+ = 494.5 Example 61

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-( 3-methyl-4-morpholino- £aj Me%1.5-(methy]aniinpJ-6 _: (3-niethynmj;dazoL4J-cJpyndinr7 _: yl). _: 3-(3:methy.l _: 4- i??oiphplinp _: anilinoJpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (23 mg, 0.030 mmol) was added to 4-(4-bromo-2-methyl-phenyl)morpholine (131 mg, 0.510 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin- 7-yl)py ^r azi ^ne -2-carboxylate (80 mg, 0.26 mmol), and cesium carbonate (250 mg, 0.77 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-(3-methyl-4-morpholin o-anilino)pyrazine-2- carboxylate (0.030 g, 24%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.30 (3H, s), 2.83 (4H, t), 2.94 (3H, d), 3.70 - 3.78 (4H, m), 3.83 (3H, s), 4.02 (3H, s), 7.05 (1H, d), 7.59 - 7.73 (2H, m), 7.94 (1H, br q), 8.51 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.36 (1H, s); m/z\ (ES+), [M+H]+ = 489.3

{b).5r£MethjJamino) _: 6-(3-methylimidazo[4 _: 5-cJpjridin _: 7-_yl)-3 _: (3-methyl-4-inorpholino _: andinpjpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(3-methyl-4-morpholino-a nilino)pyrazine-2-carboxylate (35 mg, 0.07 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 8-38% MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-(3-methyl-4-morpholino-anilino)pyrazine-2-carboxamide (12 mg, 35%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.29 (3H, s), 2.82 (4H, t), 2.97 (3H, d), 3.74 (4H, t), 4.02 (3H, s), 7.04 (1H, d), 7.35 (1H, s), 7.59 - 7.68 (2H, m) 7.74 (1H, s), 8.02 (1H, br q), 8.53 (1H, s), 8.74 (1H, s), 9.02 (1H, s), 11.39 (1H, s); m/z\ (ES+), [M+H]+ = 474.3

Example 62

3-(3.5-Dimethyl-4-morpholino-anilino)-5-(methylamino)-6-( 3-methylimidazor4.5-clpyridin-

7-vDpyrazine-2-carboxamide

{aJ.M.ethyl. J.:.(3 ₁ 5-dim_ethyJ_-4 _: m_orphpJ_i_no-anij_i_noJ _: _5_-(methxl_aminp)_-6-(3 _: _methylj.mi4a?Pl4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of cesium carbonate (312 mg, 0.960 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol) and 4-(4-bromo-2,6-dimethyl- phenyl)morpholine (172 mg, 0.640 mmol) in 1,4-dioxane (1.5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 10 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(3,5-dimethyl-4-morpholino-anilino)-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.080 g, 50%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.32 (6H, s), 2.95 (3H, d), 3.01 (4H, t), 3.64 - 3.74 (4H, t), 3.83 (3H, s), 4.02 (3H, s), 7.52 (2H, s), 7.97 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.35 (1H, s); m/z\ (ES+), [M+H]+ = 503.3

{¾ _. 3rX3 _: 5-Dimethyb-4 _: morphphnp:anibinp)-5-(methylarninp)-6-(3-methylimidazp b4 ₁ 5- c]pyridm-7 _: ylJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-(3,5-dimethyl-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (75 mg, 0.15 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 25-40% MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-(3,5-dimethyl-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (36 mg, 48%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.32 (6H, s), 3.00 (7H, m), 3.69 (4H, t), 4.02 (3H, s), 7.37 (1H, s), 7.49 (2H, s), 7.75 (1H, s), 8.03 (1H, br q), 8.53 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.38 (1H, s); m/z\ (ES+), [M+H]+ = 488.2

Example 63 3-(3-Cvano-4-morpholino-anilino)-5-(methylamino)-6-(3-methyl imidazor4.5-clpyridin-7-

{aJ.Methyl J.:i3:_cya_np-4:m_orphpJ_i_no-anij_i_noJ _: _5_-(methyJ.aiTiino)-6-(3 _: methyl.irnida.?oI4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (22 mg, 0.020 mmol) was added to 5-bromo-2-morpholino-benzonitrile (128 mg, 0.480 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (75 mg, 0.24 mmol), and cesium carbonate (234 mg, 0.720 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(3-cyano-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (0.060 g, 50%) as a yellow solid; 1H NMR (DMSO, 300 MHz) d 2.92 (3H, d), 3.11 (4H, t), 3.78 (4H, t), 3.84 (3H, s), 4.02 (3H, s), 7.22 (1H, d), 7.90 (1H, d), 8.01 (1H, br q), 8.42 (1H, d), 8.49 - 8.54 (1H, m), 8.55 (1H, s), 9.07 (1H, d), 10.40 (1H, s); m/z\ (ES+), [M+H]+ = 500.2

{¾ _. 3rX3-Cyanp-4 _: mprphphnp:anibinp)-5-(methylarninp)-6-(3-methylimidazp b4 ₁ 5-c] _. pyridin-7- y _. Upyra?ine-2-carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-(3-cyano-4-morpholino- anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (55mg, 0.11 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Sunfire prep C18 column, 17-30% MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-(3-cyano-4-morpholino-anilino)-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (28 mg, 53%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.96 (3H, d), 3.04 - 3.11 (4H, m), 3.73 - 3.80 (4H, m), 4.02 (3H, s), 7.21 (1H, d), 7.43 (1H, s), 7.80 (1H, s), 7.83 (1H, d), 8.10 (1H, br q), 8.45 (1H, d), 8.53 (1H, s), 8.74 (1H, s), 9.04 (1H, s), 11.57 (1H, s); m/z\ (ES+), [M+H]+ = 485.1 Example 64

3-(3-Methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-m ethylimidazor4.5-c1pyridin-7-

(a) 4:0 _. :Bromo:2-methoxy-phenyl)morpholine

4-Bromo-l-iodo-2-m ethoxy -benzene (120 mg, 0.38 mmol) was added to a mixture of morpholine (50 mg, 0.58 mmol), Xantphos Pd G3 (36 mg, 0.040 mmol), and cesium carbonate (375 mg, 1.15 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm, XBridge Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-ThO as eluent, and 0.1% ammonium bicarbonate as modifier, to afford 4-(4-bromo-2-methoxy-phenyl)morpholine (0.080 g, 77%) as a yellow solid. 1H NMR (DMSO, 300 MHz) d 2.90 - 2.98 (4H, m), 3.66 - 3.75 (4H, m), 3.80 (3H, s), 6.82 (1H, d), 7.02 - 7.10 (2H, m); m/z\ (ES+), [M+H]+ = 272.0

{bJ _. Methyl _. 3 -(3 -methoxy-4-mprpholino-anilinp):5 -(methylamino)-6:(3 ^methylimidazg^S: c]pyridin:7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (40 mg, 0.04 mmol) was added to a suspension of cesium carbonate (431 mg, 1.32 mmol), 4-(4-bromo-2-methoxy-phenyl)morpholine (120 mg, 0.44 mmol) and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2-carboxylate (138 mg, 0.440 mmol) in 1,4-dioxane (11 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(3-methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-meth ylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.100 g, 45%) as a yellow solid. 1H NMR (DMSO, 300 MHz) d 2.90-3.00 (7H, m), 3.67-3.77 (4H, m), 3.83 (3H, s), 3.84 (3H, s), 4.02 (3H, s), 6.89 (1H, d), 7.16-7.24 (1H, m), 7.63 (1H, d), 7.92 (1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.04 (1H, s),

10.43 (1H, s); m/r. (ES+), [M+H]+ = 505.3

_. (cJ _. 3 ₇ i3 ₇ Methoxy-4 _: morpholinq-ani^linq)-5-(iriethylaiTiinq)-6-(3 _:t riethyliiriidazob4 ₁ 5 _: cdpyndin-

_. 7 _. -yi)pyr¾?ine ₇ 2-carbpxamide 7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-(3-methoxy-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (80 mg, 0.16 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, decreasingly polar mixtures ofMeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-(3-methoxy-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxamide (25 mg, 31%) as a yellow solid; 1H NMR (DMSO, 400 MHz) 52.88 - 2.94 (4H, m), 2.97 (3H, d), 3.68-3.74 (4H, m), 3.83 (3H, s), 4.00 (3H, s), 6.87 (1H, d), 7.08-7.14 (1H, m), 7.32 (1H, s), 7.65 (1H, d), 7.72

Example 65

3-r3-(DifluoromethvD-4-morpholino-anilinol-5-(methylamino )-6-(3-methylimidazor4.5- ( ^a ) rir.B rom o-2_:(_di_fl uorom ethyl) -1 dodo-benzene

2-Methoxy-N-(2-m ethoxy ethyl)-N-(trifluoro-X ⁴ -sulfanyl)ethanamine (712 μL, 3.86 mmol) was added to a solution of 5-bromo-2-iodo-benzaldehyde (600 mg, 1.93 mmol) in DCM (10 mL) under nitrogen. The resulting mixture was stirred at 25 C for 16 hours. The reaction was then diluted with DCM (200 mL) and washed sequentially with saturated aqueous sodium bicarbonate (100 mL) and brine (50 mL). The organic layer was dried over NaiSCL, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0- 20% EtOAc-petroleum ether as eluent, to afford 4-bromo-2-(difluoromethyl)-l-iodo-benzene (0.400 g, 62%) as a colorless oil; 1HNMR (400 MHz, CDCh) d 6.72 (1H, t), 7.30-7.37 (1H, m), 7.71 - 7.78 (2H, m); poor ionization by LCMS _. (bJ _. 4 _. -I4-Bromo-2-(diflupromethyl)phenyl]iTiprphpline

Pd(OAc)2 (27.6 mg, 0.12 mmol) was added to morpholine (129 mΐ, 1.48 mmol), 4-bromo-2- (difluoromethyl)-l-iodobenzene (410 mg, 1.23 mmol), Cesium carbonate (1.20 g, 3.69 mmol), and rac-BINAP (77 mg, 0.12 mmol) in 1,4-dioxane (16 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford 4-[4-bromo-2-(difluoromethyl)phenyl]morpholine (0.160 g, 45%) as a yellow oil; 1H NMR (300 MHz, CDCh) d 2.90 - 2.99 (4H, m), 3.82 - 3.91 (4H, m), 6.79 - 7.24 (2H, m), 7.55-7.64 (1H, m), 7.79 (1H, d).

{c)M9thy) _. J _. :X3-(dj _. fluprgmethyl)-4-mprpholino-anilinoJ:5-(methylamino)-6: (3: methyhmidazg£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (32 mg, 0.040 mmol) was added to a suspension of 4-[4-bromo-2- (difluoromethyl)phenyl]morpholine (154 mg, 0.530 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (110 mg, 0.35 mmol), and cesium carbonate (343 mg, 1.05 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then filtered and the filtrate was concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[3-(difluoromethyl)-4-morpholino- anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.100 g, 54% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 2.82 - 2.91 (4H, m), 2.94 (3H, d), 3.71 - 3.80 (4H, m), 3.85 (3H, s), 4.02 (3H, s), 7.26 (1H, t), 7.38 (1H, d), 7.61 - 7.71 (1H, m), 7.92 - 8.06 (1H, m), 8.50 (1H, s), 8.51 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.51 (1H, s). m/z: (ES+), [M+H]+ = 525.1

{¾.3rI3-(DiflupromethylJ-4-mo^)holino-anilinoJ _: 5-(methylamino)-6 _: (3 _: methylimidazg£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (12 mL, 84 mmol) was added to methyl 3-[3-(difluoromethyl)-4- morpholino-anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (90 mg, 0.17 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Xselect CSH OBD column, 25-35% MeCN-H ₂ 0 as eluent, and 0.1% formic acid as modifier, to afford 3-[3-(difluoromethyl)-4-morpholino-anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (22 mg, 25%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.81 - 2.90 (4H, m), 2.97 (3H, d), 3.71 - 3.80 (4H, m), 4.02 (3H, s), 7.04 - 7.39 (2H, m), 7.43 (1H, d), 7.56-7.66 (1H, m), 7.79 (1H, s), 8.01-8.12 (1H, m), 8.50 (1H, d), 8.53 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.62 (1H, s); m/z: (ES+), [M+H]+ = 510.2

Example 66

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-( 2-rnethyl-4-morpholino- anilino)pyrazine-2-carboxamide

(a) Methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(2- methyl-4- rnorphol i no-anil ino)py_razi_ne-2 _: _c_arbox J_ate

BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), 4-(4-bromo-3 -methyl -phenyl)morpholine (327 mg, 1.28 mmol), and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(2- methyl-4-morpholino- anilino)pyrazine-2-carboxylate (0.080 g, 26%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.33 (3H, s), 2.85 (3H, d), 3.09 (4H, m), 3.75 (4H, m), 3.83 (3H, s), 4.02 (3H, s), 6.83 (1H, m), 6.90 (1H, d), 7.88 (1H, br q), 8.16 (1H, d), 8.49 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 10.12 (1H, s); m/z (ES+), [M+H]+ = 489.2

5-(Methylamino)-6-(3-methylimidazo[4,5-cJpyridin-7-y.l)-3 :(2:methyl 4-moipholino _: anilino)pyrazine-2-carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-(2-methyl-4-morpholino-a nilino)pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting suspension was stirred at 100 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 10-35% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-(2-methyl-4-morpholino-anilino)pyrazine-2-carboxamide (40 mg, 50%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.32 (3H, s), 2.90 (3H, d), 3.07 (4H, m), 3.74 (4H, m), 4.02 (3H, s), 6.82 (1H, m), 6.88 (1H, d), 7.29 (1H, s), 7.72 (1H, s), 7.96 (1H, br q), 8.30 (1H, m), 8.55 (1H, s), 8.75 (1H, s), 9.04 (1H, s), 11.18 (1H, s); m/z\ (ES+), [M+H]+ = 474.2

Example 67

3-(2-Methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-m ethylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

{ajMethylJ _. rX^-methox _j. rfl-mgipholinQ-anilinQ^S^methylaminpJ-e-Q-methylimidaz oL^S- c]pyridin:7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (116 mg, 0.130 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), 4-(4-bromo-3-methoxy-phenyl)morpholine (174 mg, 0.640 mmol), and cesium carbonate (416 mg, 1.28 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(2-methoxy-4-morpholino-anilino)-5-(methylamino)-6-(3-meth ylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.120 g, 37%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 2.93 (3H, d), 3.07 - 3.14 (4H, m), 3.72 - 3.81 (4H, m), 3.82 (3H, s), 3.92 (3H, s), 4.01 (3H, s), 6.53 (1H, d), 6.72 (1H, s), 7.96 (1H, br q), 8.45 - 8.52 (2H, m), 8.55 (1H, s), 9.03 (1H, s), 10.60 (1H, s) m/z: (ES+), [M+H]+ = 505.3

{¾ _. 3 _r X2-Methoxy-4-morpholino:anilinpJ-5-(methylaminp):6-(3- methylimidazoX4,5-c}pyridin:

Z-yi)pyr¾?ine:2-carbpxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-(2-methoxy-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (120 mg, 0.24 mmol). The resulting mixture was stirred at 80 °C for 1 day. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column using a 5 micron, 30 x 150 mm Sunfire prep C18 column, 12-30% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-(2-methoxy-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (30 mg, 25%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.95 (3H, d), 3.10 (4H, t), 3.75 (4H, t), 3.89 (3H, s), 4.01 (3H, s), 6.48 - 6.55 (1H, m), 6.69 (1H, d), 7.17 (1H, s), 7.65 (1H, s), 8.01 (1H, br q), 8.52 (1H, s), 8.53 (1H, s), 8.73 (1H, s), 9.00 (1H, s), 11.42 (1H, s); m/z: (ES+), [M+H]+ = 490.1

Example 68

3-(2-Chloro-4-morpholino-anilino)-5-(methylamino)-6-(3-me thylimidazor4.5-clpyridin-7-

£a)..MethylJ.:(2-ch]pro _: 4-mprp_hqlin_o.-ani_lin_o)-5-(m_ethyJ_ami_nq).-6 _: (3-methyHmi_dazo[4_,_5- clpyxidin-7 _: yj)pyraz_i_ne-2 _: _carbpxyja_te

Brettphos Pd G3 (116 mg, 0.130 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), 4-(4-bromo-3-chloro-phenyl)morpholine (177 mg, 0.640 mmol), and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (1 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 12% MeOH-DCM as eluent, to afford methyl 3-(2-chloro-4-morpholino-anilino)-5-(methylamino)-6-(3-methy limidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (137 mg, 42% yield). 1HNMR (400 MHz, DMSO-d6) d 2.87 (3H, d), 3.09 - 3.14 (4H, m), 3.71 - 3.75 (4H, m), 3.82 (3H, s), 4.01 (3H, s), 6.99 (1H, dd), 7.09 (1H, d), 7.92 (1H, br q), 8.46 - 8.53 (2H, m), 8.54 (1H, s), 9.05 (1H, s), 10.55 (1H, s). m/z: (ES+), [M+H]+ = 509.3

{¾.3 _r X2-Chloro:4-mQrphoHno-anilino):5-(methylamino)-6:(3-me thylimidazo[4 _i 5-c]pyridin-7: y _. URyra?ine _. -2 _: carbqxylic acid

Sodium hydroxide (44.0 mg, 1.10 mmol) was added to a suspension of methyl 3-(2-chloro-4- morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (112 mg, 0.220 mmol) in MeOH (0.5 mL) and water (0.5 mL). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was acidified with 2 M HC1, and the resulting solid was filtered to afford 3-(2-chloro-

4-morpholino-anilino)-5-(methylamino)-6-(3-methylimidazo[ 4,5-c]pyridin-7-yl)pyrazine-2- carboxylic acid (105 mg, 96%) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 2.87 (3H, d), 3.08 - 3.15 (4H, m), 3.71 - 3.77 (4H, m), 4.08 (3H, s), 7.00 (1H, dd), 7.10 (1H, d), 7.81 (1H, br q), 8.48 (1H, d), 8.76 (1H, s), 8.82 (1H, s), 9.37 (1H, s), 10.82 (1H, s). m/z\ (ES- ), [M-H]- = 494.2

_. (cJ _.J rf^ _T C.hlqro _T ^-morpholino-anilinof-^fmethylarninoj-b-Q-methylimidaz of^S-cJpyridinr _. ?- y _. URyra?ine _. -2 _: carbpxamide

HATU (104 mg, 0.270 mmol) was added to a mixture of 3-(2-chloro-4-morpholino-anilino)-

5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyr azine-2-carboxylic acid (90 mg, 0.18 mmol) and DIPEA (95 μL, 0.55 mmol) in DMF (5 mL). The resulting solution was stirred at 25 °C for 30 minutes. Ammonium chloride (49 mg, 0.91 mmol) was added. The resulting mixture was stirred at 25 °C for 16 hours. The reaction was then poured into water. The resulting suspension was filtered, washed with water (10 mL), and dried under vacuum. The resulting solid was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-(2-chloro-4-morpholino-anilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (30 mg, 33%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.91 (3H, d), 3.06 - 3.16 (4H, m), 3.66 - 3.79 (4H, m), 4.01 (3H, s), 6.98 (1H, dd), 7.07 (1H, d), 7.30 (1H, s), 7.72 (1H, s), 8.01 (1H, br q), 8.52 (1H, s), 8.56 (1H, d), 8.73 (1H, s), 9.02 (1H, s), 11.55 (1H, s); m/z\ (ES+), [M+H]+ = 494.2

Example 69 5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r(5- methyl-6-morpholino-3- pyridvDaminolpyrazine-2-carboxamide

_. (a) 4:{3:Methyl-5 _: nitro-2-pyridyl)morpholine DIPEA (0.40 mL, 2.3 mmol) was added to a mixture of 2-chloro-3-methyl-5-nitro-pyridine (200 mg, 1.16 mmol) and morpholine (121 mg, 1.39 mmol) in THF (5 mL). The resulting mixture was stirred at 80 °C for 21 hours. The reaction was then concentrated. The resulting residue was treated with water. The resulting suspension was filtered to afford 4-(3 -methyl-5 - nitro-2-pyridyl)morpholine. .(b).5.-Methyl-6-moiphplino _: pyridin-3 _: amine

A mixture of 10 wt% palladium on carbon (238 mg, 2.24 mmol) and 4-(3-methyl-5-nitro-2- pyridyl)morpholine (500 mg, 2.24 mmol) in MeOH (10 mL) was stirred under a hydrogen atmosphere at 25 C for 12 hours. The reaction was then filtered through sand and Celite and washed with methanol. The resulting filtrate was concentrated to afford 5-methyl-6- morpholino-pyridin-3 -amine (430 mg, 99%) as an off-white solid. m/z\ (ES+), [M+H]+ =

194.2

{c)Methyl _. 6-chlorg-5-(methylamino) _. :3-[(5-methyl-6 _: moiphQlino:3-pyridyl)aminoJpyrazine-

2-carb.Qxyl.4te

DIPEA (0.254 mL, 1.45 mmol) was added to solution of 5-methyl-6-morpholino-pyridin-3- amine (187 mg, 0.97 mmol) and methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2- carboxylate (213 mg, 0.970 mmol) in DMF (5 mL). The resulting mixture was stirred at 150 °C for 13 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-100% EtOAc-hexanes and then isocratic 10% MeOH-DCM, to afford methyl 6-chloro-5-(methylamino)-3-[(5- methyl-6-morpholino-3-pyridyl)amino]pyrazine-2-carboxylate (153 mg, 40%) as a pale yellow solid, m/z: (ES+), [M+H]+ = 393.3

_. (dJ _. Mcthy! _. 5 _.-. (rnethylamino)-6 _r (3 _: methylimidazg[4 ₁ 5 _: c]pyridin-7ryI)r3 _. -[(5-rnethyl-6-

.91orph_o]j_no _: _3_-pyri_dyJJamin_oJp_yrazi_ne-2-carb_oxyJ_ate CatacXium A Pd G3 (34 mg, 0.050 mmol), bis(pinacolato)diboron (240 mg, 0.94 mmol), potassium acetate (139 mg, 1.41 mmol), 7-bromo-3-methyl-imidazo[4,5-c]pyridine (100 mg, 0.47 mmol), and cataCXium A (17 mg, 0.050 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.5mL) was added. The resulting mixture was stirred at 90 C for 14 hours. The reaction was allowed to cool to room temperature and set aside.

PdCk(dppf) (31 mg, 0.040 mmol), methyl 6-chloro-5-(methylamino)-3-[(5-methyl-6- morpholino-3-pyridyl)amino]pyrazine-2-carboxylate (166 mg, 0.420 mmol), and cesium fluoride (193 mg, 1.27 mmol) were combined in a microwave vial, which hwas evacuated and backfilled three times with nitrogen. DMF (1.5 mL) and the borylation mixture were sequentially added by syringe. The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was partitioned between ethyl acetate and water. The organic layer was separated, dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(5-methyl-6-morpholino- 3-pyridyl)amino]pyrazine-2- carboxylate (50 mg, 24% yield) as a brown solid. m/z\ (ES+), [M+H]+ = 490.4 {?X5 _:i (Meth l^jnq)-6 _:( (3 _: meth Hmid^ £4 5 _: c]p ridin-7 _r ylJ-3-I 5 _: methyl:6-inorpholino-3- pyri dyl jam i_ ii p]py r azi n e _: 2 - carb ox am i de

Lithium hydroxide (24.5 mg, 1.02 mmol) was added to a suspension of methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(5-m ethyl-6-morpholino-3- pyridyl)amino]pyrazine-2-carboxylate (50 mg, 0.10 mmol) in water (0.500 mL) and MeOH (0.500 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was redissolved in DMF (3 mL). Ammonium chloride (15 mg, 0.29 mmol), HATU (72 mg, 0.19 mmol), and DIPEA (0.050 mL, 0.29 mmol) were sequentially added. The resulting mixture was stirred at 25 C for 12 hours. The reaction was then quenched with water and diluted with ethyl acetate. The layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated.. The resulting residue was purified by silica gel chromatography, using 0-100% MeOH-DCM as eluent. The resulting material was further purified by preparative HPLC, using 0-70% MeCN-FFO as eluent, and 0.1% trifluoroacetic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin- 7-yl)-3-[(5-methyl-6-morpholino-3-pyridyl)amino]pyrazine-2-c arboxamide (15 mg, 33% yield) as a pale yellow solid; 1H NMR (500MHz, DMSO-d6) 2.29 (3H, s), 2.95 (3H, d), 2.98 - 3.06 (4H, m), 3.71 - 3.79 (4H, m), 4.02 (3H, s), 7.38 (1H, br s), 7.76 (1H, br s), 7.98 - 8.11 (2H, m), 8.53 (1H, s), 8.58 (1H, d), 8.73 (1H, s), 9.03 (1H, s), 11.36 (1H, s); m/r. (ES+), [M+H]+ = 475.5

Example 70

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r r5-inethyl-6-r(3S)-3- methylmorpholin-4-yl1-3-pyridyl1amino1pyrazine-2-carboxamide {4)X3SJ _r 4-(5-Bromo-3 _: methyl _: 2-pyridyl)-3-methyl-mprpholine

(3S)-3-Methylmorpholine (10.65 g, 105.3 mmol) was added to 5 -bromo-2-fluoro-3 -methyl- pyridine (2.00 g, 10.5 mmol). The resulting mixture was stirred at 140 °C for 14 days. The reaction was then concentrated, diluted with EtOAc (50 mL), and washed three times with brine (50 mL each). The organic layer was dried over sodium, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petroleum ether as eluent, to afford (3S)-4-(5-bromo-3-methyl-2-pyridyl)-3-methyl-morpholine (1.10 g, 39%) as a colorless oil; 1 El NMR (300 MHz, DMSO-d6) d 0.84 (3H, d), 2.22 (3H, s), 2.69 - 2.82 (1H, m), 3.02 - 3.16 (1H, m), 3.26 - 3.40 (1H, m), 3.42 - 3.54 (1H, m), 3.68 (2H, dd), 3.74 (1H, dd), 7.78 (1H, dd), 8.24 (1H, dd). m/r. (ES+), [M+2+H]+ = 273.0 .(bJ _. Methy! _. 5 _. -(rnethyJamino)-6 _r (3 _: methy'limidazp[4 ₁ 5 _: c]pyridin-7ryI)r3 _. -[L5-rnethyl-6-£(3S)-3- methyJmpiphphn-4 _: yl2 _: 3-pyridylJaminoJpyrazine-2-carbgxylate Cesium carbonate (218 mg, 0.670 mmol) was added to a mixture of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (70 mg, 0.22 mmol), (3S)-4-(5-bromo-3-methyl-2-pyridyl)-3-methyl-morpholine (61 mg, 0.22 mmol), and BrettPhos Pd G3 (31 mg, 0.030 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-100% MeOH-DCM as eluent to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6-[(3S)- 3-methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxyla te (50 mg, 44% yield) as a yellow solid, m/z : (ES+), [M+H]+ = 504.3

{c) _. 5:{Methylaminp)-6-(3-methylimidazo^4 ₁ 5-c] _. pyridin-7-yl)-3-[^5 _: methyl:6-[(3S)-3: i?3.?thyJmpipholin-4 _: yl2 _: 3-pyridylJaminoJpyrazine-2-carbgxamide

7N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-6-[(3S)-3-met hylmorpholin-4-yl]-3- pyridyl]amino]pyrazine-2-carboxylate (90 mg, 0.18 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm, XSelect CSH Prep Cl 8 OBD column, 10% to 20% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6-[(3S)-3- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxamide (32 mg, 36%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 0.80 (3H, d), 2.29 (3H, s), 2.75 (1H, ddd), 2.94 - 3.04 (4H, m), 3.32 (1H, dd), 3.41 - 3.50 (1H, m), 3.65 - 3.73 (1H, m), 3.73 - 3.84 (2H, m), 4.02 (3H, s), 7.40 (1H, s), 7.77 (1H, s), 8.05 (1H, d), 8.14 (1H, d), 8.53 (1H, s), 8.60 (1H, d), 8.74 (1H, s), 9.03 (1H, s), 11.43 (1H, s); m/z\ (ES+), [M+H]+ = 489.2

Example 71 5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vO-3-ri5- methyl-6-IY2S)-2- methylmorpholin-4-yll-3-pyridyllaminolpyrazine-2-carboxamide

{4)X2SJ _r 4:(5-Bromo-3 _: methyl:2-pyridyl)-2-methyl-mgrpholine

DIPEA (1.38 mL, 7.89 mmol) was added to a solution of 5-bromo-2-fluoro-3-methyl-pyridine (0.500 g, 2.63 mmol) and (2S)-2-methylmorpholine (0.399 g, 3.95 mmol) in DMSO (15 mL).

The resulting mixture was stirred at 100 °C for 4 days. The reaction was then diluted with EtOAc and washed sequentially with water. The organic layer was dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% EtOAc-petr oleum ether as eluent, to afford (2S)-4-(5-bromo-3-methyl-2- pyridyl)-2-methyl-morpholine (0.520 g, 73%) as a yellow oil; 1H NMR (300 MHz, DMSO- d6) d 1.12 (3H, d), 2.24 (3H, d), 2.53 (1H, d), 2.72 - 2.87 (1H, m), 3.17 - 3.32 (2H, m), 3.60 - 3.76 (2H, m), 3.80 - 3.91 (1H, m), 7.75 (1H, dd), 8.19 (1H, dd); m/r. (ES+), [M+H]+ = 270.9

(bJ _. M94hy! _. 5 _.2 (iI!ethyJaminQ) _. -6r _. (3:rnethy'limidazo[4 ₁ 5 _: c]pyridin-7ryI)r3 _. -[L5-rnethyl-6-£(2S)-2- methylmprpholin-4 _: yl} _: 3-pyridylJaminpJpyrazine-2-carbgxylate Brettphos Pd G3 (46 mg, 0.050 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (80 mg, 0.26 mmol), (2S)-4-(5-bromo-3-methyl-2-pyridyl)-2-methyl-morpholine (69 mg, 0.26 mmol), and cesium carbonate (250 mg, 0.77 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6-[(2S)- 2-methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxyla te (85 mg, 66%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) 5 1.13 (3H, d), 2.29 (3H, s), 2.52 - 2.58 (1H, m), 2.80 (1H, d), 2.90 (3H, d), 3.16 - 3.22 (2H, m), 3.62 - 3.77 (2H, m), 3.83 (3H, s), 3.85 - 3.90 (1H, m), 4.01 (3H, s), 7.96 (1H, br s), 8.06 (1H, s), 8.44 - 8.52 (1H, m), 8.54 (2H, d), 9.05 (1H, s), 10.25 (1H, s); m/r. (ES+), [M+H]+ = 504.3

{c) _. 5:{Methylamjnp)-6 _: X3-methyhmidazp^4 ₁ 5 _: c] _. pyridin-7 _r ylJ-3-[^5 _: methyl _: _6-[(2_S)-2 _: methylmpipholin-4 _: yl2 _: 3-pyridylJaminoJpyrazine-2-carbgxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-6-[(2S)-2-met hylmorpholin-4-yl]-3- pyridyl]amino]pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Shield RP18 OBD column, 11%-21% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-m ethyl-6-[(2S)-2- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxamide (21 mg, 27%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.13 (3H, d), 2.28 (3H, s), 2.55 (1H, s), 2.72 - 2.82 (1H, m), 2.94 (3H, d), 3.16 (2H, dd), 3.65 - 3.74 (2H, m), 3.81 - 3.88 (1H, m), 4.01 (3H, s), 7.39 (1H, s), 7.76 (1H, s), 7.94 - 8.07 (2H, m), 8.50 - 8.58 (2H, m), 8.72 (1H, s), 9.02 (1H, s),

11.35 (1H, s). m/z: (ES+), [M+H]+ = 489.3

Example 72 5-Cvclopropyl-6-(3-methylimidazor4.5-clp _y ridin-7-vD-3-rr6-r(3R)-3-methylmorpholin-4-vn-

3-pyridyllaminolpyrazine-2-carboxamide

{4)X3R)-3:M.Qthyl-4:{5:nitro-2-pyridyl)morpholine

DIPEA (1.9 mL, 10.90 mmol) was slowly added to a solution of (3R)-3-methylmorpholine hydrochloride (500 mg, 3.63 mmol) and 2-chloro-5-nitropyridine (1.15 mg, 7.27 mmol) in DMF (15 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature, quenched with water (50 mL), and extracted three times with EtOAc (50 mL each). The combined organic layers were washed twice with 5% aqueous LiCl solution and once with brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-hexanes as eluent, to afford (3R)-3-methyl-4-(5-nitro-2-pyridyl)morpholine (0.321 g, 40%) as a yellow oil; 1H NMR (500 MHz, CHLOROFORM-d) 1.36 (3H, d), 3.38 (1H, td), 3.62 (1H, td), 3.77

(1H, dd), 3.85 (1H, d), 4.07 (1H, dd), 4.12 - 4.21 (1H, m), 4.48 (1H, br dd), 6.56 (1H, d), 8.26

(1H, dd), 9.09 (1H, d); m/z: (ES+), [M+H]+ = 224.1 {¾ _. Methyl _. 6-cMoro-5:cyclppropyl-3-[[6 _: [(3R)-3 _: methylmoipholin-4-yll _: 3- pyri dyl Jam i_ n o]py r azi n e _: 2- carb ox y j ate

A mixture of 10 wt% palladium on carbon (32 mg, 0.030 mmol) and (3R)-3-methyl-4-(5- nitro-2-pyridyl)morpholine (321 mg, 1.44 mmol) in MeOH (9.6 mL) was stirred under a hydrogen atmosphere at 25 C for 18 hours. The reaction was then filtered, and the filtrate was concentrated. The resulting residue was dissolved in DMF (6.5 mL). Methyl 6-chloro-5- cyclopropyl-3-fluoro-pyrazine-2-carboxylate (0.365 g, 1.58 mmol) and DIPEA (0.755 mL, 4.32 mmol) wwere sequentially added. The resulting mixture was stirred at 100 °C for 60 hours. The reaction was then allowed to cool to room temperature, diluted with water, and extracted three times with EtOAc (30 mL each). The combined organic layers were washed twice with 5% aqueous LiCl and once with brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-5-cyclopropyl-3-[[6-[(3R)-3- methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxylate (0.254 g, 44%) as a dark orange solid; 1HNMR (500MHz, CHLOROFORM-d) d 1.06 - 1.20 (2H, m), 1.22 - 1.28 (5H, m), 2.46 - 2.55 (1H, m), 3.18 - 3.29 (1H, m), 3.62 - 3.70 (1H, m), 3.72 - 3.81 (2H, m), 3.91 - 3.97 (1H, m), 4.00 (3H, s), 4.02 - 4.07 (1H, m), 4.23 - 4.34 (1H, m), 6.60 (1H, br d), 7.68 (1H, br d), 8.30 (1H, br s), 9.76 (1H, br s); m/z\ (ES+), [M+H]+ = 404.1 (?) Methy! 5 -cyclppropyl .-6 _: (3-methylimi dazo[4 _^ 5 _: c]pyri din-7 _: ylj _: 3-[[6- [(3R) _: 3- methy)mgipholin-4-yl2-3 _. -pyridylJaminpJpyrazine-2-carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (200 mg, 0.94 mmol), bis(pinacolato)diboron (479 mg, 1.89 mmol), cataCXium A Pd G3 (68.7 mg, 0.09 mmol), cataCXium A (33.8 mg, 0.09 mmol), and potassium acetate (185 mg, 1.89 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (4.2 mL) was added. The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature and set aside.

Methyl 6-chloro-5-cyclopropyl-3-[[6-[(3R)-3-methylmorpholin-4-yl]-3 - pyridyl]amino]pyrazine-2-carboxylate (254 mg, 0.630 mmol), Pd(dppf)C12*CH2C12 complex (51 mg, 0.060 mmol), and cesium fluoride (287 mg, 1.89 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then allowed to cool to room temperature, treated with water, and extracted three times with 4:1 DCM/IPA. The combined organic layers were washed once with 5% aqueous LiCl solution and once with brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 1% ammonia as modifier, to afford methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[6-[(3R)-3-methylmorpho lin-4-yl]-3- pyridyl]amino]pyrazine-2-carboxylate (0.122 g, 39%) as a brown film, m z: (ES+), [M+H]+ = 501.2

{dJ _. 5rCycloprgpyl-6 _: {3 _: methylimidazg[4 _L 5 _: c]pyridin-7 _: ylJ-3-_[[6-[(3R)-3-methylmoipholin _: _4- yJJ:.3. ₂ P.yi.(dyJJamingJpyraz_ine_-2 _: carbpxami_de 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to a solution of methyl (R)-5- cyclopropyl-6-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-3-((6 -(3-methylmorpholino)pyridin- 3-yl)amino)pyrazine-2-carboxylate (122 mg, 0.240 mmol) in methanol (2.0 mL). The resulting suspension was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 1% ammonia as modifier, to afford 5-cyclopropyl-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[[6-[(3R)-3-methylmorpholin-4-yl]-3-pyridy l]amino]pyrazine-2- carboxamide (57 mg, 48%) as a dark yellow film. 1HNMR (500MHz, CHLOROFORM-d) 0.88 - 0.99 (2H, m), 1.15 - 1.32 (5H, m), 1.91 - 2.05 (1H, m), 3.25 (1H, td), 3.67 (1H, td), 3.73 - 3.87 (3H, m), 3.99 - 4.06 (4H, m), 4.29 (1H, q), 5.41 (1H, br d), 6.62 (1H, d), 7.80 (1H, br d), 7.87 (1H, dd), 8.04 (1H, s), 8.46 (1H, d), 8.66 (1H, s), 8.93 (1H, s), 10.57 (1H, s); m/r

(ES+), [M+H]+ = 486.2

Example 73 3-r(5-Cvano-6-morpholino-3-pyridvnaminol-5-(methylamino)-6-( 3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide

_. (a) _. 5rBromo-2-morpholinp-pyridine-3 _r carbonitriJe

DIPEA (1.21 mL, 6.90 mmol) was added to a mixture of 5-bromo-2-chloro-pyridine-3- carbonitrile (500 mg, 2.30 mmol) and morpholine (300 mg, 3.45 mmol) in MeCN (10 mL). The resulting solution was stirred at 80 °C for 2 hours. The reaction was then allowed to cool to room temperature, then poured into ice water. The resulting precipitate was collected by filtration, washed with water (25 mL), and dried under vacuum to afford 5-bromo-2- morpholino-pyridine-3-carbonitrile (0.480 g, 78 %); 1H NMR (400 MHz, CDC13) d 3.69 - 3.75 (4H, m), 3.80 - 3.87 (4H, m), 7.86 (1H, d), 8.37 (1H, d); m/r (ES+), [M+H]+ = 268.0

£bJ.Methyl 3_-[(5_-cy_ano _: _6-mp_rph_ol_in_o-3 _: pyridyl)_ami_no]_-5 _: (m_ethyl_aminoJ _: 6_-(_3_- methyhmMazp[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carboxylate BrettPhos Pd G3 (57.8 mg, 0.06 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 5-bromo-2-morpholino-pyridine-3-carbonitrile (128 mg, 0.480 mmol), and cesium carbonate (312 mg, 0.96 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 15 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford methyl 3-[(5-cyano-6-morpholino-3-pyridyl)amino]-5-(methylamino)-6- (3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.081 g, 51%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.87 (3H, d), 3.48 - 3.53 (4H, m), 3.73 - 3.77 (4H, m), 3.84 (3H, s), 4.01 (3H, s), 8.02 (1H, br q), 8.50 (1H, s), 8.53 (1H, s), 8.69 (1H, d), 8.78 (1H, d), 9.05 (1H, s), 10.23 (1H, s); m/r. (ES+), [M+H]+ = 501.2

_. (cJ _.J rliS-Cyanp-CirmorphpJino _Tj -pyridyJJaminoJyS-frnethyJaminof-Cirfjymethylimidazp^d ^: cIpyxidin-7 _: yJ)pyraz_i_ne-2 _: _carboxami_de

7 N methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[(5-cyano-6-morpholino- 3-pyridyl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]py ridin-7-yl)pyrazine-2- carboxylate (75 mg, 0.15 mmol). The resulting mixture was stirred at 80 °C for 50 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, decreasingly polar mixtures ofMeCN-H ₂ 0 as eluent, and 0.1% formic acid as modifier, to afford 3-[(5-cyano-6- morpholino-3-pyridyl)amino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (16 mg, 22%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.91 (3H, d), 3.47 (4H, t), 3.71 - 3.78 (4H, m), 4.01 (3H, s), 7.40 (1H, s), 7.76 (1H, s), 8.08 (1H, br q), 8.51 (1H, s), 8.69 - 8.77 (3H, m), 9.02 (1H, s), 11.41 (1H, s); m/z\ (ES+), [M+H]+ = 486.3

Example 74

3-(Y4-(E4-Oxazepan-4-vDphenyr)amino)-6-(3-methyl-3H-imida zor4.5-clpyridin-7-vD-5-

(methylamino)pyrazine-2-carboxamide

(a) 4-(4 _: Bromopheny 1)- 1 , 4-oxazep ane

Palladium (II) acetate (0.119 g, 0.530 mmol) and l-bromo-4-iodo-benzene (1.00 g, 3.53 mmol) were added to a mixture of potassium tert-butoxide (1.19 g, 10.6 mmol), 1,4- oxazepane hydrochloride (0.486 g, 3.53 mmol), and (rac)-BINAP (0.33 g, 0.53 mmol) in toluene (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-20% EtOAc-petroleum ether, to afford 4-(4-bromophenyl)-l,4- oxazepane (0.370 g, 41%) as a red solid; 1H NMR (400 MHz, DMSO-d6) 5 1.81 - 1.94 (2H, m), 3.49 - 3.62 (6H, m), 3.69 (2H, dd), 6.65 - 6.80 (2H, m), 7.22 - 7.30 (2H, m); m/r. (ES+), [M+H]+ = 256.0

£bJ.Methyj 5_-(m_et_hyJ_ami_no)_-6-(3 _: _methyJ_im_i_daz_o£4 ₁ 5 _: _c]pyri_d_i_n-7:yJJ:3-[4-(j.,4-oxazep_an-4 _: y]j4ndinpJpyrazine-2-carbpxylate

4-(4-Bromophenyl)-l,4-oxazepane (245 mg, 0.960 mmol) was added to a suspension of cesium carbonate (624 mg, 1.91 mmol), methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (200 mg, 0.64 mmol), and BrettPhos Pd G3 (87 mg, 0.10 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (l,4-oxazepan- 4-yl)anilino]pyrazine-2-carboxylate (0.130 g, 42%) as a yellow solid, m/r. (ES+), [M+H]+ = 489.2

(c) _. 3 _r ((4-f 1 _. ,4-Oc^z6r4 ^h -4 _: g1)r56 ^h c!)ίΐirί ^h o)-6 _: (3-itΐ6ΐ5c1-3H-ίitiί4ίΐzo[4,5-o]rgp4ί ^h -7-c!)-5 _G {iPpthylaminoJpyrazine-2 _: carbpxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l,4-oxazepan-4-yl)an ilino]pyrazine-2-carboxylate (100 mg, 0.21 mmol). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 3-((4-(l,4-oxazepan-4-yl)phenyl)amino)- 6-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)py razine-2-carboxamide (56 mg, 56%) as a red solid; 1H NMR (400 MHz, DMSO-d6) d 1.90 (2H, p), 2.93 (3H, d), 3.51 - 3.61 (6H, m), 3.72 (2H, dd), 4.00 (3H, s), 6.70 - 6.79 (2H, m), 7.27 (1H, d), 7.54 - 7.63 (2H, m), 7.66 - 7.70 (1H, m), 8.00 (1H, br q), 8.51 (1H, s), 8.72 (1H, s), 8.99 (1H, s), 11.18 (1H, s); m/z\ (ES+), [M+H]+ = 474.2

Example 75 5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-IT5- methyl-6-r(3R)-3- methylmorpholin-4-yll-3-pyridyllaminolpyrazine-2-carboxamide

{4)X3R)-4:i5:Bromo _: 3-methyl-2 _: pyridyl)-3 -methyl-morpholine

(3R)-3-Methylmorpholine (266 mg, 2.63 mmol) was added to a mixture of 5-bromo-2-fluoro- 3 -methyl-pyridine (500 mg, 2.63 mmol), potassium tert-butoxide (886 mg, 7.89 mmol), palladium(II) acetate (89 mg, 0.39 mmol), and (rac)-BINAP (246 mg, 0.390 mmol) in toluene (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford (3R)-4-(5-bromo-3-methyl-2-pyridyl)-3-methyl- morpholine (0.200 g, 28%) as a red solid; ¹ H NMR (300 MHz, DMSO-d6) d 0.84 (3H, d), 2.22 (3H, s), 2.77 - 2.82 (1H, m), 3.03 - 3.15 (1H, m), 3.43 - 3.55 (1H, m), 3.65 - 3.69 (2H, m), 3.71 - 3.78 (1H, m), 3.78 - 3.89 (1H, m), 7.78 (1H, dd), 8.24 (1H, d); m/z\ (ES+),

[M+H]+ = 271.0

_. (bJ _. Methy! _. 5 _. -fiI!ethyJaminQ)- _. 6r _. (3:methxlimidazq[4 ₁ 5 _: c]pyridiri-7ryI)r3- _. [L5-rnethyl-6-£(3R)-3- m ethylm prpholi n_-4 _T y!]-3 -pyri dyljam i npjpyrazi _n er_2-carb oxylate

(3R)-4-(5-Bromo-3-methyl-2-pyridyl)-3-methyl-morpholine (104 mg, 0.38 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.96 mmol) and BrettPhos Pd G3 (43.4 mg, 0.05 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6-[(3R)- 3-methylmorpholin-4-yl]-3-pyridyl]amino]pyrazine-2-carboxyla te (0.060 g, 37%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 0.81 (3H, d), 2.29 (3H, s), 2.74 - 2.81 (1H, m), 2.91 (3H, d), 2.99 - 3.07 (1H, m), 3.13 - 3.25 (1H, m), 3.42 - 3.50 (1H, m), 3.63 - 3.84 (3H, m), 3.84 (3H, s), 4.02 (3H, s), 7.96 (1H, br q), 8.17 (1H, d), 8.50 (1H, s), 8.53 (1H, s), 8.61 (1H, d), 9.06 (1H, s), 10.32 (1H, s); m/r. (ES+), [M+H]+ = 504.3

{c) _. 5:{MethylarninQ)-6-(3-methylimidazo^4 ₁ 5-c] _. pyridin-7-yl)-3-[[5 _: methyl _: 6-[(3R) _: 3- methylmQrpholin-4 _: yl} _: 3-pyridylJaminoJpyrazine-2-carbgxamide 7 N Methanolic ammonia (8 mL, 56 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-6-[(3R)-3-met hylmorpholin-4-yl]-3- pyridyl]amino]pyrazine-2-carboxylate (50.0 mg, 0.10 mmol). The resulting suspension was stirred at 90 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD C18 column, 26-36% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[[5-methyl-6-[(3R)-3-methylmorpholin-4-yl] -3-pyridyl]amino]pyrazine-2- carboxamide (0.021 g, 43.1 %) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 0.79 (3H, d), 2.29 (3H, s), 2.69 - 2.80 (1H, m), 2.93 - 3.03 (4H, m), 3.29 (1H, s), 3.41 - 3.48 (1H, m), 3.68 (1H, t), 3.78 (2H, td), 4.02 (3H, s), 7.39 (1H, s), 7.77 (1H, s), 8.05 (1H, br q), 8.14 (1H, d), 8.53 (1H, s), 8.60 (1H, d), 8.73 (1H, s), 9.03 (1H, s), 11.43 (1H, s); m/z\ (ES+), [M+H]+ = 489.2

Example 76

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-r(TR.4R)-2-oxa-5- azabicvclor2.2.11heptan-5-yllanilinolpyrazine-2-carboxamide

{a)XlR ₃ 4R)-5 _: {4 _: Bromophenyl)-2-oxa-5 _: azabicyclo[2_.2._l]heptane

(lR,4R)-2-Oxa-5-azabicyclo[2.2.1]heptane (500 mg, 5.04 mmol) was added to a mixture of 1- bromo-4-iodobenzene (1.43 g, 5.04 mmol), potassium tert-butoxide (1.70 g, 15.1 mmol), (rac)-BINAP (314 mg, 0.500 mmol), and palladium(II) acetate (113 mg, 0.500 mmol) in toluene (5 mL) at RT under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc in petroleum ether as eluent, to afford (lR,4R)-5-(4- bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (0.200 g, 16%) as a red solid; 1H NMR (400 MHz, DMSO-d6) d 1.84 (1H, ddt), 1.92 (1H, dd), 2.93 (1H, dt), 3.47 (1H, dd), 3.63 (1H, dd), 3.73 (1H, dd), 4.54 (1H, dt), 4.61 (1H, t), 6.54 - 6.64 (2H, m), 7.25 - 7.33 (2H, m). m/z\

(ES+), [M+2+H]+ = 256.0

{bJ.Methyl 5-(methylamino)-6 _: (3 _: methylimidazpb4 ₁ 5 _: c]pyridin-7:ylJ:3-[4-[(.lR _J 4R)-2 _: pxa-5 _: azabicyclo[2 _. .2._l]heptan-5 _: ylJanilinp] _. pyrazine-2-carbpxylate Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxylate (100 mg, 0.32 mmol), (lR,4R)-5-(4-bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (81 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazi ne-2-carboxylate (0.070 g, 45% yield) as a red solid, m/z: (ES+), [M+H]+ = 487.2

_. (c) _. 5 ₇ (Methylaminp)-6-(3 _r methylirnidazo{4,5 _r c}pyridin-7-yJ)-3-[4-[(l R,4R) _: 2-oxa-5- azabicyclo[2 _. .2._l]heptan-5_ _: ylJanilinp] _. pyrazine-2-carbpxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(lR,4R)-2-oxa-5-azab icyclo[2.2.1]heptan-5- yl]anilino]pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(lR,4R)-2- oxa-5-azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carbox amide (7.0 mg, 12%) as a red solid; 1HNMR (400 MHz, DMSO-d6) d 1.83 (1H, d), 1.93 (1H, d), 2.90 - 2.98 (4H, m), 3.50 11.19 (1H, s). m/z: (ES+), [M+H]+ = 472.2

Example 77

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-r(TS.4S)-2-oxa-5- azabicvclor2.2.11heptan-5-yllanilinolpyrazine-2-carboxamide

_. (a) _. ( LS ₁ 4S)-5 _r (4 _: 13romopheny!)-2-oxa-5 _: azabicyclo[2.2,jJheptane

(lS,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane hydrochloride (500 mg, 3.69 mmol) was added to a mixture of l-bromo-4-iodo-benzene (1043 mg, 3.69 mmol), potassium tert-butoxide (1.24 g, 11.1 mmol), palladium(II) acetate (83 mg, 0.37 mmol), and (rac)-BINAP (230 mg, 0.37 mmol) in toluene (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petroleum ether as eluent, to afford (lS,4S)-5-(4- bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (97 mg, 10% yield) as a red solid; lH NMR (400 MHz, DMSO-d6) d 1.84 (1H, ddt), 1.92 (1H, dd), 2.93 (1H, dt), 3.47 (1H, dd), 3.63 (1H, dd), 3.73 (1H, dd), 4.54 (1H, dt), 4.61 (1H, t), 6.54 - 6.64 (2H, m), 7.25 - 7.33 (2H, m). m/z\

(ES+), [M+H]+ = 254.1 {b).Methyl_5_-Xmethylamino)-6 _: 0 _: methyHmidazp[ _i 4 ₁ 5 _: c]pyridin-7 _: yl_)-3_-[_4-[(_l_S ₁ 4S) _: 2-oxa-5- azabicycl_oL20._lJ_heptan_-5 _: y]Jani_li_n_oJp_y_razi_ne-2-carb_oxyJ_ate

(lS,4S)-5-(4-Bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptan e (97 mg, 0.38 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.26 mmol), cesium carbonate (250 mg, 0.77 mmol) and BrettPhos Pd G3 (34.7 mg, 0.04 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(l S,4S)-2-oxa- 5-azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxylat e (0.060 g, 48% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.82 - 1.84 (1H, m), 1.87 - 1.93 (1H, m), 2.87 (3H, d), 2.89 - 2.96 (1H, m), 3.47 - 3.49 (1H, m), 3.64 - 3.71 (2H, m), 3.80 (3H, s), 3.99 (3H, s), 4.50 - 4.52 (1H, m), 4.55 - 4.61 (1H, m), 6.63 (2H, d), 7.59 (2H, d), 7.88 (1H, br q), 8.48 (1H, s), 8.52 (1H, s), 9.02 (1H, s), 10.17 (1H, s). m/z: (ES+), [M+2H] ²⁺ = 244.1 _. (c) _. 5 ₇ (MethyJaminp)-6-(3 _r methylirnidazo[4,5 _r c}pyridin-7-yJ)-3-[4-[(l S,4S) _: 2-oxa _T 5- azabicyclo[2_.2._l]heptan-5_ _: ylJanilinp] _. pyrazine-2-carbpxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(lS,4S)-2-oxa-5-azab icyclo[2.2.1]heptan-5- yl]anilino]pyrazine-2-carboxylate (50 mg, 0.10 mmol) at rt. The resulting mixture was stirred at 90 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 15-40 MeCN/H20 as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(lS,4S)-2-oxa-5-azab icyclo[2.2.1]heptan-5- yl]anilino]pyrazine-2-carboxamide (5.0 mg, 10%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 1.83 (1H, d), 1.93 (1H, d), 2.90 - 3.00 (4H, m), 3.46 - 3.56 (1H, m), 3.66 - 3.79 (2H, m), 4.02 (3H, s), 4.52 (1H, s), 4.60 (1H, s), 6.65 (2H, d), 7.29 (1H, s), 7.61 (2H, d), 7.70 (1H, s), 8.00 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.20 (1H, s). m/z\ (ES+), [M+H]+ = 472.2

Example 78

3-r2-Fluoro-4-r(lS.4S)-2-oxa-5-azabicvclor2.2.11heptan-5- yllanilinol-5-(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

£aj. Methyl. J.:I2-fluoro-4 _: £(_l S_,4S)-2 _: _oxa-5 _: _azabi_cy_doL2,_2,_l_]h_ept_an-5-yj2ani_l_in_o]. _: 5- {methylamino)-6-(3-methylimidazo[4 ₃ 5-cJpyridin-7-yl)pyrazine: _. 2-carboxylate BrettPhos Pd G3 (87 mg, 0.10 mmol) was added to a suspension of (lS,4S)-5-(4-bromo-3- fluoro-phenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (347 mg, 1.28 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (16 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-25% MeOH-DCM as eluent, to afford methyl 3-[2-fluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5- yl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin -7-yl)pyrazine-2-carboxylate (0.140 g, 44%) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.84 (1H, d), 1.93 (1H, d), 2.84 (3H, d), 2.98 (1H, d), 3.50 (1H, d), 3.69 (1H, d), 3.69 (1H, d), 3.83 (3H, s), 4.01 (3H, d), 4.61 (2H, d), 6.44-6.52 (1H, m), 6.60-6.72 (1H, m), 7.90 (1H, br q), 8.24 (1H, t), 8.43 - 8.56 (2H, m), 9.02 (1H, d), 10.23 (1H, d). m/z\ (ES+), [M+H]+ = 505.2

_. (bJ _. 3rI2-Fluoro-4 _r £( l S ₁ 4S)-2 _r pxa-5 _: azabjyyylo[2.2,jJheptan-5-yl]anilinp]-5-(rriethyJaiTii no)-6 _T i3-methylimid^o[4 _^ 5-c]pyridin-7 _.r yljpyrazine-2-carbpxamide

7 N Methanolic ammonia (16.0 mL, 112 mmol) was added to methyl 3-[2-fluoro-4-[(lS,4S)- 2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (120 mg, 0.24 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XSelect CSH OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[2-fluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl] anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (0.042 g, 36%) as a yellow solid. 1H NMR (DMSO-d6, 400 MHz) d 1.80 - 1.87 (1H, m), 1.89-1.96 (1H, m), 2.91 (3H, d), 2.97 (1H, d), 3.45-3.52 (1H, m), 3.69 (1H, d), 3.74 (1H, d), 4.01 (3H, s), 4.56 (1H, s), 4.61 (1H, s), 6.42-6.50 (1H, m), 6.58-6.68 (1H, m), 7.31 (1H, d), 7.71 (1H, d), 7.99 (1H, br q), 8.34 (1H, t), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.24 (1H, d). 19F

NMR (376 MHz, DMSO) d -127.15, -127.39. m/z: (ES+), [M+H]+ = 490.2

Example 79 3-r2.3-Difluoro-4-rnS.4S)-2-oxa-5-azabicvclor2.2.11heptan-5- yllanilinol-5-(methylamino)-6- (3-methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

_. (a) _. ( LS ₁ 4S)-5 _r (4 _: 13romo _: 2 _J 3-ditluorq-phenyl)-2 _: pxa-5 _T azabicyclo[2.2.1]heptane Palladium(II) acetate (63 mg, 0.28 mmol) was added to a mixture of l-bromo-2,3-difluoro-4- iodobenzene (900 mg, 2.82 mmol), (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride (421 mg, 3.10 mmol), cesium carbonate (3.22 g, 9.88 mmol), and rac-BINAP (176 mg, 0.280 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-petroleum ether as eluent, to afford (lS,4S)-5-(4- bromo-2,3-difluoro-phenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (0.420 g, 51%) as a yellow solid; 1HNMR (300 MHz, CDC13) d 1.91 - 2.10 (2H, m), 3.21 - 3.32 (1H, m), 3.60-3.72

(1H, m); m/z: (ES+), [M+H]+ = 290.1 i¾.Methyl.3-[2 ₃ 3-difluoro ₇ 4-IXlS ₃ 41¾-2-oxa-5-^abicyclpI2.2..^heptan _: 5.- _i y.l]Miilino]-5- {mpthylaminoJ-6-X3-methylimidazp[4,5-_c]pyridin-7-yl)pyrazin e:2_-carboxylate

BrettPhos Pd G3 (87 mg, 0.10 mmol) was added to a suspension of (lS,4S)-5-(4-bromo-2,3- difluoro-phenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (278 mg, 0.960 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (16 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[2,3-difluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5 - yl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin -7-yl)pyrazine-2-carboxylate (0.140 g, 42%) as a yellow solid; 1HNMR (DMSO-d6, 300 MHz) d 1.76 - 2.02 (2H, m), 2.84 (3H, d), 3.06-3.17 (1H, m), 3.59 - 3.70 (1H, m), 3.72 - 3.89 (5H, m), 4.00 (3H, s), 4.55

(2H, d), 6.65 (1H, t), 7.96 (1H, br q), 7.99 - 8.14 (1H, m), 8.42 - 8.61 (2H, m), 9.02 (1H, d),

10.30 (1H, s); m/z: (ES+), [M+H]+ = 523.2

(cJJ^I^.j-Djfluo^fl-tfl S^S^^-oxa-S-azabicyclo^?.?. l_]heptan-5 _: yJJanili_no_l _: _5_- {methylaminoJ:6-X3-methylimidazo[4 ₃ 5-cJpyndin _: 7-y!)pyrazine _: 2-carboxamide 7 N Methanolic ammonia (12 mL, 84 mmol) was added to methyl 3-[2,3-difluoro-4-[(lS,4S)- 2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (120 mg, 0.23 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, decreasingly polar mixtures of MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-[2,3-difluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5 -yl]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (25 mg, 21%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.79 - 1.87 (1H, m), 1.89-1.96 (1H, m), 2.91 (3H, d), 3.06-3.14 (1H, m), 3.59-3.67 (1H, m), 3.76 (1H, d), 3.84 (1H, d), 4.01 (3H, s), 4.49 (1H, s), 4.58 (1H, s), 6.65 (1H, t), 7.38 (1H, s), 7.75 (1H, s), 7.99 (1H, br q), 8.14-8.22 (1H, m), 8.52 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.44 (1H, d); m/z : (ES+), [M+H]+ = 508.3

Example 80

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 2.3.5-trifluoro-4-r(TS.4S)-2-oxa-

5-azabicvclor2.2.11heptan-5-yllanilinolpyrazine-2-carboxa mide

_. (aJ _.i LS^Sf-^f^J^-Tritluqro _T d-nitrq-phenyU-^-oxa-^azabicyclo^J _. jJheptane

DIPEA (1.79 mL, 10.3 mmol) was added to a solution of l,2,3,4-tetrafluoro-5-nitro-benzene (2.00 g, 10.3 mmol) and (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1.02 g, 10.3 mmol) in acetonitrile (15 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% DCM-petroleum as eluent, to afford (lS,4S)-5-(2,3,6-trifluoro- 4-nitro-phenyl)-2-oxa-5-azabicyclo[2.2.1]heptane (1.70 g, 61% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.84 - 2.04 (2H, m), 3.41 - 3.53 (1H, m), 3.80 - 3.93 (3H, m), 4.65 (1H, s), 4.77 - 4.87 (1H, m), 7.85 - 7.94 (1H, m). m/z\ (ES+), [M+H]+ = 275.0 £bJ.2,_3 _J _5-Tritl_uorp-4-l((l_S,_4Sj-2-oxa _: _5-azabjcy_cJ_o[2,_2,_lJhep_tan _: _5_-yJJan_i_Hne Iron powder (815 mg, 14.6 mmol) was added to a mixture of ammonium chloride (780 mg, 14.6 mmol) and (lS,4S)-5-(2,3,6-trifluoro-4-nitro-phenyl)-2-oxa-5-azabicycl o[2.2.1]heptane (800 mg, 2.92 mmol) in EtOH (7 mL) and water (7 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was taken into water, treated with saturated aqueous sodium bicarbonate, and extracted with dichloromethane. The extract was dried over sodium sulfate, filtered, and concentrated to afford 2,3,5-trifluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5 -yl]aniline (0.670 g, 94% yield) as a purple solid. 1H NMR (300 MHz, DMSO-d6) d 1.70 - 1.92 (2H, m), 3.13 (1H, d), 3.39 - 3.50 (1H, m), 3.62 - 3.84 (2H, m), 4.14 (1H, s), 4.52 (1H, s), 5.21 (2H, d), 6.32 - 6.44 (1H, m). m/z: (ES+), [M+H]+ = 245.2

_. (c)d _. LS ₁ 4S)-5 _r (4 _: Bromo:2 _J 3,6-trit]uoro _: phenyJ) _r 2-oxa _: 5-azabicyclpX2 _; 2 _; Qheptane 2,3,5-Trifluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5 -yl]aniline (300 mg, 1.23 mmol) was added to tert-butylnitrite, tech, grade (190 mg, 1.84 mmol) and trimethylbromosilane (188 mg, 1.23 mmol) in dibromomethane (5 mL) under nitrogen. The resulting mixture was stirred at room temperature for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc- petroleum ether as eluent, to afford (lS,4S)-5-(4-bromo-2,3,6-trifluoro-phenyl)-2-oxa-5- azabicyclo[2.2. ljheptane (0.210 g, 56% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.73 - 2.00 (2H, m), 3.15 - 3.24 (1H, m), 3.66 - 3.91 (3H, m), 4.49 - 4.64 (2H, m), 7.39 - 7.49 (1H, m). m/z\ (ES+), [M+H]+ = 308.0

{^.Methyl 5_-(methylamino)-6 _: _(3 _: methyhm_idazq£4 ₁ 5 _: _c]pyri_din-7:y.0:3-[2 _J _3 _J 5-trifluoro _: 4-

I(.LS,4S)_ ₂ 2:_o_x_a-5-azabi_cy_clq[_2,_2,_lJhep_tan _: 5-ylJaniJ_inp]pyrazi_ne _: _2-carboxyj_at_e

EPhos Pd G4 (67 mg, 0.070 mmol) was added to a suspension of EPhos (79 mg, 0.15 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (230 mg, 0.73 mmol), (lS,4S)-5-(4-bromo-2,3,6-trifluoro-phenyl)-2-oxa-5- azabicyclo[2.2. ljheptane (271 mg, 0.880 mmol), and cesium carbonate (718 mg, 2.20 mmol) in DMF (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-[2,3,5-trifluoro-4-[( lS,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxylate (0.072 g, 18% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.04 - 1.45 (2H, m), 1.76 - 1.98 (2H, m), 2.90 (3H, d), 3.76 - 3.90 (4H, m), 4.02 (3H, s), 4.30 - 4.72 (3H, m), 8.07 (1H, br q), 8.19 - 8.37 (1H, m), 8.43 - 8.56 (2H, m), 9.05 (1H, s), 10.56 (1H, s). m/r. (ES+), [M+H]+ = 541.2 {e) _. 5:{Methylamjnp)-6 _: X3-methyhmidazp^4 ₁ 5 _: c] _. pyridin-7 _r ylJ-3-[2 _J _3 _i 5 _: trifluqro-4-[_(lS,4S): _. 2- pxa-5 _: azab;.cydo[2.2JJheptan-5-yQanihnp].pyrazme-2-carboxami de 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[2,3,5-trifluoro-4-[(lS, 4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]anilino]pyrazine-2-carboxylate (72 mg, 0.13 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [2,3,5-trifluoro-4-[(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan- 5-yl]anilino]pyrazine-2- carboxamide (3.2 mg, 4.5% yield) as a orange solid. 1HNMR (DMSO-d6, 400 MHz) d 1.77 - 1.86 (1H, m), 1.86 - 1.98 (1H, m), 2.94 (3H, d), 3.19 (1H, d), 3.62 - 3.71 (1H, m), 3.74 - 3.85 (1H, m), 3.87 (1H, d), 4.01 (3H, s), 4.40 - 4.49 (1H, m), 4.58 (1H, d), 7.45 (1H, d), 7.80

(1H, d), 8.09 (1H, br q), 8.34 - 8.45 (1H, m), 8.52 (1H, s), 8.73 (1H, s), 9.04 (1H, s), 11.75 (1H, d). 19F NMR (376 MHz, DMSO) d -127.20, -149.07 -157.99. m/z\ (ES+), [M+H]+ = 526.3 Example 81

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-(6-oxa-3- azabicvclor 3,1,11heptan-3 -vDanilinolpyrazine-2-carboxamide {4).3:0.:Bjpmophenyl)-6-oxa-3 _: azabicyclg[.3._l,l]heptane Potassium tert-butoxide (595 mg, 5.30 mmol) was added to a mixture of 6-oxa-3- azabicyclo[3.1.1]heptane hydrochloride (240 mg, 1.77 mmol), l-bromo-4-iodo-benzene (500 mg, 1.77 mmol), palladium(II) acetate (40 mg, 0.18 mmol), and (rac)-BINAP (110 mg, 0.18 mmol) in toluene (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc in petroleum ether as eluent, to afford 3-(4- bromophenyl)-6-oxa-3-azabicyclo[3.1.1]heptane (0.300 g, 67%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 1.90 (1H, dt), 3.12 (1H, dt), 3.36 (2H, dd), 3.51 (2H, d), 4.71 (2H, dd), 6.65 - 6.74 (2H, m), 7.32 - 7.40 (2H, m); m/z\ (ES+), [M+H]+ = 254.0 _. (bJ _. Methyl _. ^^iniethyJaminQf-Or _. Q _T methyJimidazg^^^cjpyridin-y _. ryJJrJ- _. t _. d _. -fO-oxa-? _. - azabicyclo[3 _... El]heptan-3 _r yl)anilinpJpyrazine-2-carbgxylate

3-(4-Bromophenyl)-6-oxa-3-azabicyclo[3.1.1]heptane (81 mg, 0.32 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.96 mmol), and BrettPhos Pd G3 (44 mg, 0.050 mmol) in 1,4-dioxane (5 mL) at rt under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (6- oxa-3-azabicyclo[3.1.1]heptan-3-yl)anilino]pyrazine-2-carbox ylate (0.060 g, 39%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.96 (1H, d), 2.90 (3H, d), 3.11 - 3.18 (1H, m), 3.36 - 3.44 (2H, m), 3.51 - 3.58 (2H, m), 3.83 (3H, s), 4.02 (3H, s), 4.73 (2H, d), 6.77 (2H, d), 7.67 (2H, d), 8.47 (1H, d), 8.50 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 10.20 (1H, s); m/z\ (ES+), [M+2H] ²⁺ = 486.2

{c) _. 5:{Methylaming)-6-(3-methyhmidazo0 ₁ 5-c] _. pyridiri-7-yl)-3-[4-(6-oxa:3- azabicycl_oL3_._l_._lJ_heptan_-3 _: y])a_ni_li_n_oJpyrazi_ne-2-carb_oxamj_de

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(6-oxa-3-azabicyclo[3 .1.1]heptan-3- yl)anilino]pyrazine-2-carboxylate (60.0 mg, 0.12 mmol). The resulting suspension was stirred at 90 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm XSelect CSH Prep C18 OBD column, 25-33% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(6 -oxa-3- azabicyclo[3.1.1]heptan-3-yl)anilino]pyrazine-2-carboxamide (9.0 mg, 15%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 1.97 (1H, d), 2.94 (3H, d), 3.12 (1H, q), 3.38 (2H, d), 3.57 (2H, d), 4.02 (3H, s), 4.71 (2H, d), 6.76 (2H, d), 7.30 (1H, s), 7.62 - 7.73 (3H, m), 8.00 (1H, br q), 8.52 (1H, s), 8.74 (1H, s), 9.01 (1H, s), 11.20 (1H, s); m/z: (ES+), [M+H]+ =

472.2

Example 82

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-(8-oxa-3- azabicvclor 3,2,1 loctan-3 -vDanilinolpyrazine-2-carboxamide

(a) .3 :0.:Bromopheny 1)- 8 -oxa-3 -azabi cy cl o[3_ .2 , 1 ]pctane

Potassium tert-butoxide (595 mg, 5.30 mmol) was added to a mixture of 8-oxa-3- azabicyclo[3.2.1]octane, l-bromo-4-iodo-benzene (500 mg, 1.77 mmol), (rac)-BINAP (165 mg, 0.270 mmol), and palladium(II) acetate (59.5 mg, 0.270 mmol) in toluene (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 3-(4-bromophenyl)-8-oxa-3-azabicyclo[3.2.1]octane (0.200 g, 42%) as a red solid; 1H NMR (400 MHz, DMSO-d6) d 1.76 - 1.88 (4H, m), 2.78 (2H, dd), 3.33 - 3.41 (2H, m), 4.42 (2H, t), 6.75 - 6.84 (2H, m), 7.28 - 7.37 (2H, m); m/z: (ES+),

[M+H]+ = 268.0

_. (bJ _. Methyl _. ^ _. -fniethyJa _.t l'inQf-Or _. Q _T methy'limidazqbd^^cjpyridin-y _. ryJJrJ- _. t _. d _. -fS-qxa-j-

.¾abjcycJ.o[3..2JJpctan-3-yl)anilinp]pyrazine-2-carboxyl ate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (lOOmg, 0.32 mmol), (lS,5R)-3-(4-bromophenyl)-8-oxa-3-azabicyclo[3.2.1]octane (103 mg, 0.380 mmol), and Cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (8- oxa-3-azabicyclo[3.2.1]octan-3-yl)anilino]pyrazine-2-carboxy late (0.068 g, 43%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.85 (4H, s), 2.79 (2H, dd), 2.90 (3H, d), 3.37 (2H, d), 3.82 (3H, s), 4.01 (3H, s), 4.42 (2H, s), 6.86 (2H, d), 7.64 (2H, d), 7.90 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 10.24 (1H, s); m/z (ES+), [M+2H] ²⁺ = 251.1 (c) 5-(Methylamino)-6-(3-methyhmidazo[4,5-c]p ridin-7-yl)-3-[4-(8-oxa-3-

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(8-oxa-3-azabicyclo[3 .2.1]octan-3- yl)anilino]pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (8-oxa-3- azabicyclo[3.2.1]octan-3-yl)anilino]pyrazine-2-carboxamide (25 mg, 42%) as a orange solid; 1HNMR (400 MHz, DMSO-d6) d 1.76 - 1.92 (4H, m), 2.78 (2H, dd), 2.93 (3H, d), 3.36 (2H, d), 4.01 (3H, s), 4.41 (2H, s), 6.85 (2H, d), 7.29 (1H, s), 7.63 (2H, d), 7.70 (1H, s), 7.99 (1H, br q), 8.51 (1H, s), 8.72 (1H, s), 9.00 (1H, s), 11.25 (1H, s); m/z (ES+), [M+H]+ = 486.2

Example 83

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-(2-oxa-6-azaspirc>r3.31heptan-

6-vDanilino1pyrazine-2-carboxamide

(a) 6-(4-Bromophenyl)-2-oxa-6-azaspiro[3.3]heptane l-Bromo-4-iodo-benzene (500 mg, 1.77 mmol) was added to a suspension of potassium tert- butoxide (595 mg, 5.30 mmol), 2-oxa-6-azaspiro[3.3]heptane (175 mg, 1.77 mmol), (rac)- BINAP (165 mg, 0.270 mmol), and palladium (II) acetate (60 mg, 0.27 mmol) in toluene (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0- 50% MeOH-DCM as eluent, to afford 6-(4-bromophenyl)-2-oxa-6-azaspiro[3.3]heptane (0.250 g, 56%) as a yellow oil; 1H NMR (400 MHz, DMSO-d6) d 3.96 (4H, s), 4.71 (4H, s), 6.34 - 6.43 (2H, m), 7.26 - 7.34 (2H, m); m/r (ES+) [M+H]+ = 254.0 _. (bJ _. Methy! _. 5 _.2 (niethyJaminQ) _. -6r _. (3:methy'limidazp[4 ₁ 5 _: c]pyridin-7ryI)r3 _. -[ _. 4-(2-oxa-6- azaspirg[3._3]heptan-6 _: yl)anilinp] _. pyrazine-2-carbgxylate

6-(4-Bromophenyl)-2-oxa-6-azaspiro[3.3]heptane (122 mg, 0.480 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.960 mmol), and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2 -oxa-6-azaspiro[3.3]heptan-6- yl)anilino]pyrazine-2-carboxylate (0.080 g, 52%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.88 (3H, d), 3.82 (3H, s), 3.96 (4H, s), 4.01 (3H, s), 4.73 (4H, s), 6.45 - 6.53 (2H, m), 7.56 - 7.64 (2H, m), 7.90 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 10.19 (1H, s); m/r (ES+), [M+H]+ = 487.3

{c) _. 5:{Methylaming)-6-(3-methylimidazg^4 ₁ 5-c] _. pyridin-7-yl)-3-[4 _. -(2 _. -oxa:6- azaspirg[3._3]heptan-6 _: yl)aniling}pyrazine-2-carbgxamide

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-oxa-6-azaspiro[3.3 ]heptan-6-yl)anilino]pyrazine- 2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by cl 8 reverse phase chromatography, using 0-50% MeCN-H?0 as eluent and 1% formic acid as modifier, to afford a yellow solid. The resulting residue was purified further by preparative HPLC, using a 5 micron, 30 mm x 150 mm XBridge Shield RP18 OBD column, 27-35% MeCN-HiO as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-oxa-6-azaspiro[3.3 ]heptan-6-yl)anilino]pyrazine- 2-carboxamide (9.0 mg, 15%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.92 (3H, d), 3.95 (4H, s), 4.02 (3H, s), 4.72 (4H, s), 6.47 (2H, d), 7.29 (1H, s), 7.60 (2H, d), 7.70 (1H, s), 7.98 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.21 (1H, s). m/z: (ES+), [M+H]+ = 472.3

Example 84

3-Anilino-5-(methylamino)-6-(3-methylimidazor4.5-c1pyridi n-7-vDpyrazine-2-carboxamide

_. (a) _. McthyJ _.. 3:anilino-5-(mMhyJ _. amj/nq) _T 6-(3 _r methylirnidazo{4,5 _r c}py'ridin-7-yJ)pyrazine-2 _: carbpxylate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), bromobenzene (50 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.96 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-anilino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (0.090 g, 72%) as a brown solid. 1HNMR (DMSO-d6, 300 MHz) d 2.92 (3H, d), 3.82 (3H, s), 4.01 (3H, s),

7.05 (1H, t), 7.37 (2H, t), 7.82 (2H, d), 7.95 (1H, br s), 8.52 (2H, d), 9.04 (1H, s), 10.45 (1H, s); m/z: (ES+), [M+H]+ = 390.2

{¾ _. 3 _r Anilinq-5:(methylaminq)-6-(3-methylimidazo[4 ₃ 5-c]pyndin-7 _. -yl)pyrazine:2- carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-anilino-5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 0.21 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 25-40% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 3-anilino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2- carboxamide (18 mg, 23%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.96 (3H, d), 4.01 (3H, s), 6.99 - 7.02 (1H, m), 7.31 - 7.41 (3H, m), 7.73 - 7.84 (3H, m), 8.01 (1H, d), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.54 (1H, s); m/z\ (ES+), [M+H]+ = 375.2

Example 85 3-r4-(Difluoromethoxy)anilinol-5-(methylamino)-6-(3-methylim idazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

(a). M.9.thyJ.p.:I4-(ditluprpm_e_thpxyJ_aniJ_i_np]-5-(m_ethyJ_ami n_o)_ _: 6-(3 -methyl imjdazo^d,^- c]py.ridin-7 _: yljpyrazine-2 _: carbpxylate Methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (140 mg, 0.45 mmol) was added to a mixture of cesium carbonate (438 mg, 1.35 mmol), l-bromo-4-(difluoromethoxy)benzene (150 mg, 0.67 mmol), and BrettPhos Pd G3 (40 mg, 0.040 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4- (difluoromethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo [4,5-c]pyridin-7-yl)pyrazine- 2-carboxylate (0.120 g, 59%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.91 (3H,

(1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.43 (1H, s); m/z: (ES+), [M+H]+ = 456.1. {¾ _. 3-[4 _r XDiflupromethoxy)anilinpJ-5-(methylaminp):6-(3-methyli midazoX4 ₅ 5-c}pyridin:7- yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[4- (difluoromethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo [4,5-c]pyridin-7-yl)pyrazine- 2-carboxylate (80 mg, 0.18 mmol). The resulting mixture was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Xselect CSH OBD column, 18-45% MeCN-EhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-(difluoromethoxy)anilino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (20 mg, 25%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.95 (3H, d), 4.02 (3H, s), 7.17 (1H, t), 7.16 - 7.29 (2H, m), 7.42 (1H, s), 7.78 (1H, s), 7.82 - 7.88 (2H, m), 8.00 (1H, br q), 8.53 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.57 (1H, s); m/z: (ES+), [M+H]+ = 441.3

Example 86

5-Cvclopropyl-3-r4-(l-hvdiOxy-l-methyl-ethvDanilino1-6-(3 -methylimidazor4.5-c1pyridin-7- (aJ _. MethyJ _. J _. :atpino ₇ 5-cyclopropyJ-6-(3 _r methylirnidazo[4,5 _r c}pyridin-7 _r yJ)pyrazine-2 _: carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (0.477 g, 2.25 mmol), bis(pinacolato)diboron (1.14 g, 4.50 mmol), CataCXiumA Pd G3 (0.164 g, 0.230 mmol), CataCXium A (0.081 g,

0.23 mmol), and potassium acetate (0.442 g, 4.50 mmol) were combined in a microwave vial, which was evacuated and backfilled with nitrogen 3 times. DMF (10 mL) was added and the resulting mixture was stirred at 80 °C for 24 h. The reaction was then allowed to cool to room temperature and set aside.

Methyl 3-amino-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate (0.341 g, 1.50 mmol), Pd(dppf)-CH2Ck complex (0.122 g, 0.150 mmol), and cesium fluoride (0.684 g, 4.50 mmol) were combined in a microwave vial, which was evacuated and backfilled with nitrogen 3 times. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then allowed to cool to room temperature, diluted with water, and extracted with 4:1 DCM/IPA 3 times. The combined organic layers were washed once each with 5% aqueous LiCl solution and brine, dried over sodium sulfate, filtered, and concenrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM with 0-1% ammonia as eluent. The resulting material was further purified by trituration in ethyl acetate to afford methyl 3-amino-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.105 g, 22%) as a beige solid; 1H NMR (500MHz, CHLOROFORM-d) d 0.85 - 0.93 (2H, m), 1.14 - 1.23 (2H, m), 1.85 - 1.95 (1H, m), 3.93 (3H, s), 4.00 (3H, s), 8.00 (1H, s), 8.65 (1H, br s), 8.91 (1H, br s). The NH2 signal exchanged out in chloroform-d; m/z: (ES+), [M+H]+ = 325.1

{¾ _. MethyL5-cycloprQpyl:3:X4 _: (l _: hydroxy:d-methyl-ethyl)anilinp] _. :6-(3 _: methylimidazQ^4 ₁ 5 _: c]pyridm-7 _: yljpyrazine-2 _: carbpxylate

Methyl 3-amino-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine-2- carboxylate (100 mg, 0.31 mmol), 2-(4-bromophenyl)propan-2-ol (133 mg, 0.620 mmol), BrettPhos Pd G3 (28 mg, 0.030 mmol), and cesium carbonate (300 mg, 0.92 mmol) were combined in a microwave vial, which was then evacuated and backfilled with nitrogen three times. 1,4-dioxane (3.08 mL) was added. The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then allowed to cool to room temperature, diluted with water (25 mL), and extracted three times with 3:1 DCM/IPA (10 mL each). The combined organic layers were washed with water and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent and 0.2% ammonia as modifier to afford methyl 5-cy cl opropyl-3-[4-(l -hydroxy- 1 -methyl-ethyl)anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (89 mg, 63% yield) as a yellow solid. 1H NMR (500MHz, CHLOROFORM-d) d 0.95 - 1.01 (2H, m), 1.28 - 1.33 (2H, m),

1.63 (6H, s), 1.94 - 2.02 (1H, m), 3.98 (3H, s), 4.01 (3H, s), 7.49 (2H, d), 7.66 (2H, d), 8.02 (1H, s), 8.67 (1H, s), 8.91 (1H, s), 10.33 (1H, s). The OH peak was broadened to the baseline. m/z: (ES+), [M+H]+ = 459.3

_. (c) _. 5-Cyclppropyl-3 -[4-( 1 -hydroxy - 1 _. rmethyl-ethyl)anilino]-6-(3 -methylimidazo[4, 5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (3.88 mL, 27.2 mmol) was added to methyl 5-cyclopropyl-3-[4-(l- hydroxy-l-methyl-ethyl)anilino]-6-(3-methylimidazo[4,5-c]pyr idin-7-yl)pyrazine-2- carboxylate (0.089 g, 0.19 mmol). The resulting mixture was stirred at 100 °C in a Biotage microwave reactor for 2 hours. The reaction was then concentrated and dried under vacuum to afford 5-cy clopropyl-3-[4-(l -hydroxy- l-methyl-ethyl)anilino]-6-(3-methylimidazo[4, 5- c]pyridin-7-yl)pyrazine-2-carboxamide (80 mg, 93% yield). 1HNMR (500MHz, DMSO-d6) d 0.92 (2H, br dd), 1.05 - 1.12 (2H, m), 1.43 (6H, s), 1.88 - 1.98 (1H, m), 3.99 (3H, s), 4.93 (1H, s), 7.44 (2H, br d), 7.59 (2H, br d), 7.83 (1H, br s), 8.09 (1H, br s), 8.44 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 11.26 (1H, s). m/z: (ES+), [M+H]+ = 444.3 Example 87

3-(4-Isopropoxyanilino)-5-(methylamino)-6-(3-methylimidaz or4.5-c1pyridin-7-vnpyrazine-2- carboxamide £aj Methyl J.:^:isppropoxyani!inoJ-5 _: (methylamj;np). _: 6-(3 _: methyh;midazpI4 ₁ 5 _: clpyridin-7- y _. URyrazine-2 _: carbpxylate

Methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol) was added to a mixture of l-bromo-4-isopropoxy -benzene (69 mg, 0.32 mmol), cesium carbonate (312 mg, 0.960 mmol), and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-(4- isopropoxyanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c] pyridin-7-yl)pyrazine-2- carboxylate (0.060 g, 42%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.27 (6H, d), 2.89 (3H, d), 3.82 (3H, s), 4.01 (3H, s), 4.57 (1H, heptet), 6.92 (2H, d), 7.68 (2H, d), 7.93

(1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.25 (1H, s); m/r. (ES+), [M+H]+ = 448.2

£bJ.3-(4_-Isqprpp_o_xyanjJ_i_no)_-5 _: _(methyj_am_i_noJ-6-(_3_-methy]jm_idazp[4,_5-c]pyri_di ri _: 7- yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 3-((4- isopropoxyphenyl)amino)-6-(3-methyl-3H-imidazo[4,5-c]pyridin -7-yl)-5-

(methylamino)pyrazine-2-carboxylate (80 mg, 0.18 mmol). The resulting mixture was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD C18 column, 33- 53% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 3-(4-isopropoxyanilino)-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (51 mg, 66%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.25 (6H, d), 2.91 (3H, d), 4.00 (3H, s), 4.54 (1H, heptet), 6.89 (2H, d), 7.30 (1H, s), 7.65 (2H, d), 7.70 (1H, s), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 8.99 (1H, s), 11.30 (1H, s); m/z: (ES+), [M+H]+ = 433.2

Example 88 r4-rr3-Carbamoyl-6-(methylamino)-5-(3-methylimidazor4.5-c1py ridin-7-vDpyrazin-2- yllaminolphenyll methanesulfonate

_. (a) _. MethyJ _. X:chlqro-5-(methylaminp) _T 3X4-methylsulfqnyloxyani]inp)pyrazine-2 _T carbpxylate DIPEA (0.22 mL, 1.2 mmol) was added to a mixture of 4-aminophenyl methanesulfonate (78 mg, 0.41 mmol), methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2-carboxylate (100 mg, 0.46 mmol) in DMA. The resulting mixture was stirred at 150 °C for 15 hours. The reaction was then diluted with water. The resulting precipitate was collected by filtration and dried under air to afford methyl 6-chloro-5-(methylamino)-3-(4- methylsulfonyloxyanilino)pyrazine-2-carboxylate (0.090 g, 56%) as a brown solid; 1H NMR (500MHz, DMSO-d6) d 2.93 (3H, d), 3.35 (3H, s), 3.81 (3H, s), 7.31 (2H, br d), 7.79 (2H, d),

7.94 (1H, br q), 10.34 (1H, s); m/z: (ES+), [M+H]+ = 387.1

{¾X4-j^3 _: Carbampyl:5-chlorq-6 _: (rriethylamino)pyrazin-2 _: ylJaminq] _. phenyl] methanesulfonate

7 N Methanolic ammonia (4.0 mL, 28 mmol) was added to methyl 6-chloro-5-(methylamino)- 3-(4-methylsulfonyloxyanilino)pyrazine-2-carboxylate (90 mg, 0.23 mmol). The resulting suspension was stirred at 100 C for 15 hours in a Biotage microwave reactor. The reaction was then concentrated to afford [4-[[3-carbamoyl-5-chloro-6-(methylamino)pyrazin-2- yl]amino]phenyl] methanesulfonate (0.085 g, 98%) as a brown solid; 1HNMR (500MHz, DMSO-d6) d 2.95 (3H, d), 3.34 (3H, s), 7.22 - 7.34 (2H, m), 7.41 (1H, br s), 7.62 (1H, br s), 7.66 (1H, br q), 7.73 - 7.81 (2H, m), 11.54 (1H, s); m/z: (ES+), [M+H]+ = 372.1

_. (cj _. tX-tP-Carbampyl-eXmethylaminpJ-S-Q-methylimidazptXS-cJ pyridin-Y-yDpyrazin-?- y _. U¾rninp] _. phenyl]_ methanesulfonate CataCXium Pd G3 (47 mg, 0.060 mmol), bis(pinacolato)diboron (244 mg, 0.960 mmol), potassium acetate (189 mg, 1.92 mmol), cataCXium A (23 mg, 0.060 mmol), and 7-bromo-3- methyl-imidazo[4,5-c]pyridine (136 mg, 0.640 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.5 mL) was added. The resulting mixture was stirred at 80 °C for 20 hours. The reaction was allowed to cool to room temperature and set aside.

PdCk(dppf) (47 mg, 0.060 mmol), cesium fluoride (292 mg, 1.92 mmol), and [4-[[3- carbamoyl-5-chloro-6-(methylamino)pyrazin-2-yl]amino]phenyl] methanesulfonate (238 mg, 0.640 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-60% MeOH-DCM as eluent, to afford [4-[[3- carbamoyl-6-(methylamino)-5-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazin-2- yl]amino]phenyl] methanesulfonate (60 mg, 20%) as a pale yellow solid; 1H NMR (500 MHz, DMSO-d6) d 2.97 (3H, d), 3.37 (3H, s), 4.02 (3H, s), 7.34 (2H, d), 7.43 (1H, br s), 7.80 (1H, br s), 7.90 (2H, d), 8.04 (1H, br q), 8.53 (1H, s), 8.74 (1H, s), 9.04 (1H, s), 11.68 (1H, s); m/z: (ES+), [M+H]+ = 469.2

Example 89 3-r4-(2-Methoxyethoxy)anilino1-5-(methylamino)-6-(3-methylim idazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

{4)Methy) _. J _. :X4-(2 _: methoxyethoxy)anilino]-5:(methylamino)-6-(3-methylimid azo[4,5- c]pyridin:7 _: yljpyrazine-2 _: carbpxylate l-Bromo-4-(2-methoxyethoxy)benzene (74 mg, 0.32 mmol) was added to methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.960 mmol), and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[4-(2- methoxyethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (0.080 g, 54%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.88 (3H, d),

3.63 - 3.68 (2H, m), 3.82 (3H, s), 4.01 (3H, s), 4.06 - 4.11 (2H, m), 6.95 (2H, d), 7.69 (2H, d), 7.92 (1H, br s), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.25 (1H, s); the ethereal methyl group signal was buried under the residual water peak; m/z\ (ES+), [M+H]+ = 464.2 {b).3-[4 ₇ X2 _: MethgxyethpxyJanilinoJ-5-(methyJ.arnino) _: 6-(3 _: methyhmidazo^4 ₁ 5-c2p_yridin-7- yJJnyrazine-2:carb_oxamj_de

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 3-[4-(2- methoxyethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (80 mg, 0.17 mmol). The resulting mixture was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC to afford 3-[4-(2-methoxyethoxy)anilino]-5-(methylamino)-6-(3-methylim idazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (56 mg, 72%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6)

52.91 (3H, d), 3.30 (3H, s), 3.59 - 3.68 (2H, m), 3.99 (3H, s), 4.02 - 4.11 (2H, m), 6.86 - 6.97 (2H, m), 7.32 (1H, s), 7.61 - 7.74 (3H, m), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 11.31 (1H, s); m/z: (ES+), [M+H]+ = 449.2

Example 90

3-r4-r2-(Dimethylamino)ethoxylanilinol-5-(methylamino)-6- (3-methylimidazor4.5-clpyridin-

7-vDpyrazine-2-carboxamide (aj Methyl J _.r I4 _r [2 _: (dimethylaminpJethpxy]anjJ _. inp]:5^(methyJamino)-6-(3 _: methyhmidazg£4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate 2-(4-Bromophenoxy)-N,N-dimethyl-ethanamine (94 mg, 0.38 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.96 mmol), and BrettPhos Pd G3 (43.4 mg, 0.05 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[4-[2-(dimethylamino)ethoxy]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.100 g, 66%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.34 (6H, s), 2.78 (2H, t), 2.88 (3H, d), 3.82 (3H, s), 4.01 (3H, s), 4.09 (2H, t), 6.91 - 7.01 (2H, m), 7.64 - 7.75 (2H, m), 7.92 (1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.26 (1H, s); m/z\ (ES+), [M+H]+ = 477.2 _. (bJ _. 3rI4rI2 _r (DimethyJamino)ethpxy]anilino] ₇ 5-(methyJaminp)-6-(3 ₇ methylimidazo[4,5- c]pyridin:7 ₇ yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 3-[4-[2- (dimethylamino)ethoxy]anilino]-5-(methylamino)-6-(3-methylim idazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (80 mg, 0.17 mmol). The resulting suspension was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD C18 column, 16- 43% MeCN-10 mM ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 3-[4-[2-(dimethylamino)ethoxy]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (40 mg, 52%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.20 (6H, s), 2.60 (2H, t), 2.91 (3H, d), 3.96 - 4.06 (5H, m), 6.86 - 6.96 (2H, m), 7.32 (1H, s), 7.62 - 7.74 (3H, m), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 11.31 (1H, s); m/z\ (ES+), [M+H]+ = 462.2

Example 91

3-r4-(2-Hvdroxyethoxy)anilinol-5-(methylamino)-6-(3-methy limidazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

(aj MMhylJ _. rI4 _r (2 _: hydrox _j ethoxyJaniJjnp]:5 _. -Xnie%JaminQ) _. -6: _. (3 _T rnethyIimidazo[4,5 _T c]pyridm-7 _: yljpyrazine-2 _: carbpxylate

2-(4-Bromophenoxy)ethanol (83 mg, 0.38 mmol) was added to methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.960 mmol), and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 6 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[4-(2- hydroxyethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (0.080 g, 56%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.89 (3H, d), 3.67 - 3.73 (2H, m), 3.82 (3H, s), 3.94 - 4.00 (2H, m), 4.00 (3H, s), 4.84 (1H, t), 6.96 (2H, d), 7.69 (2H, d), 7.92 (1H, br q), 8.49 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.25 (1H, s) m/r (ES+), [M+H]+ = 450.2

_. (bJ _. 3rI4r(2 _r Hydroxyethpxy)anilinoj ₇ 5-(methyJamino)-6 ₇ (3 _: methyJimidazp[4 ₁ 5 _: c]pyridin-7r yjjpyrazine-^carbox.amide

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 3-[4-(2- hydroxyethoxy)anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (60.0 mg, 0.13 mmol). The resulting suspension was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Sunfire prep C18 column, 5-25% MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-(2-hydroxyethoxy)anilino]-5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (9.0 mg, 16%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.91 (3H, d), 3.69 (2H, br q), 3.97 (2H, t), 4.01 (3H, s), 4.83 (1H, br t), 6.93 (2H, d), 7.32 (1H, s), 7.68 (2H, d), 7.72 (1H, s), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 11.30 (1H, s); m/r (ES+), [M+H]+ = 435.2 Example 92

5-(Methylamino)-6-(3-methylimidazc>r4.5-c1pyridin-7-vD -3-r4-(2- morpholinoethoxy)anilino1pyrazine-2-carboxamide £aj Methyl.5-(methy]aminoJ-6 _: (3-nieLhyJimidazoL4,5-c]pyridin.-7 _: yl). _: 3-[4-(2: thorphplinoethoxy)aniJino]pyrazine _T 2-carbpxy!ate

Methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol) was added to a suspension of 4-[2-(4- bromophenoxy)ethyl]morpholine (91 mg, 0.32 mmol), cesium carbonate (312 mg, 0.960 mmol), and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) at it under nitrogen. The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin- 7-yl)-3-[4-(2-morpholinoethoxy)anilino]pyrazine-2-carboxylat e (0.090 g, 54%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.45 - 2.49 (2H, m), 2.69 (2H, t), 2.88 (3H, d), 3.23 - 3.32 (2H, m), 3.57 - 3.61 (4H, m), 3.82 (3H, s), 4.01 (3H, s), 4.08 (2H, t), 6.95 (2H, d), 7.69 (2H, d), 7.91 (1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.26 (1H, s); m/z\ (ES+), [M+H]+ = 519.2

{¾ _. 5r£MethyJaminp):6-(3-methylimidazo[4,5-cJpyridin _: 7-yl)-3 _: [4-(2- Plorphplinoethoxy)aniJino]pyrazine _T 2-carbpxarnide

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 6-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-((4-(2- morpholinoethoxy)phenyl)amino)pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 85 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD Cl 8 column, 17-37% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[4-(2-morpholinoethoxy)anilino]pyrazine-2- carboxamide (58 mg, 100%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.40 - 2.50 (2H, m), 2.67 (2H, t), 2.91 (3H, d), 3.24 - 3.31 (2H, m), 3.52 - 3.61 (4H, m), 3.99 (3H, s), 4.06 (2H, t), 6.88 - 6.98 (2H, m), 7.31 (1H, s), 7.66 (2H, d), 7.70 (1H, s), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 11.30 (1H, s); m/z\ (ES+), [M+H]+ = 504.2

Example 93

3-(4-Aminoanilino)-5-(methylamino)-6-n-methylbenzimidazol -4-vnpyrazine-2-carboxamide

£aj Methyl J.:(4:acetamidoaniHno)-5 _: _(meth _j jaminpJ-6-(I-methy]benzimjdazol _: 4-yJJpyrazine- 2-carboxylate

BrettPhos Pd G3 (15 mg, 0.020 mmol) was added to a suspension of cesium carbonate (156 mg, 0.480 mmol), N-(4-bromophenyl)acetamide (33 mg, 0.24 mmol), and methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (50 mg, 0.16 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 24 hours. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(4-acetamidoanilino)-5-(methylamino)-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxylate (0.060 g, 84%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.05 (3H, s), 2.93 (3H, d), 3.83 (3H, s), 3.92 (3H, s), 7.39 - 7.51 (2H, m), 7.57 (2H, d), 7.60 - 7.78 (3H, m), 8.07 (1H, br q), 8.32 (1H, s), 9.87 (1H, s), 10.33 (1H, s). m/z: (ES+), [M+H]+ = 446.2

{b).3r£4 ₇ AminoanilinoJ-5-(methyJ.arninq)-6-(l _: methylbenzimidazpl-4 _: yl)pyrazine-2 _: carboxamide

32 wt% Aqueous HC1 (5.00 mL, 165 mmol) was added to a suspension of methyl 3-(4- acetamidoanilino)-5-(methylamino)-6-(l-methylbenzimidazol-4- yl)pyrazine-2-carboxylate (45 mg, 0.10 mmol), in water (1 mL). The resulting mixture was stirred at 80 °C for 24 hours.

The reaction was then filtered and the solid was dried under vacuum. 7 N methanolic ammonia (10 mL, 70 mmol) was added to a suspension of the resulting solid in MeOH (10 mL). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 5-15% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-(4-aminoanilino)-5-(methylamino)-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxamide (6.0 mg, 15%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.91 (3H, d), 3.91 (3H, s), 6.54 - 6.61 (2H, m), 7.26 (1H, s), 7.38- 7.45 (3H, m), 7.58 (1H, s), 7.60-7.67 (2H, m), 8.13 (1H, br q), 8.34 (1H, s), 10.99 (1H, s); the aniline NH2 protons are broadened to the baseline, m/r. (ES+), [M+H]+ = 389.1 Example 94

3-r4-r2-Methoxyethyl(methvnamino1anilino1-5-(methylamino) -6-(3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide

{4)MethyIJ _. :I4:^2:methoxyethyl(meth _j J)amino]anilinpJ-5:(methylamino):6-(3- methybmidazp[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carbpxylate

BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of cesium carbonate (310 mg, 0.96 mmol), 4-bromo-N-(2-methoxyethyl)-N-methyl-aniline (78 mg, 0.32 mmol) and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[2-methoxyethyl(methyl)amino]anilino]-5-(methylamino)-6 -(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (60 mg, 39%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.89 (3H, s), 2.91 (3H, s), 3.27 (3H, s), 3.42 - 3.53 (4H, m), 3.82 (3H, s), 4.02 (3H, s), 6.74 (2H, d), 7.60 (2H, d), 7.91 (1H, br q), 8.50 (1H, s), 8.55 (1H, s), 9.04 (1H, s), 10.18 (1H, s); m/r (ES+), [M+H]+ = 477.2 £bJ.3_-[4_-£2-Methp_xyethxl_(methyJJami_noJani_lin_oJ _: _5_-(m_ethyJ_ami_no)_-6 _: _(3 _: methyJ_im_i_daz_o£4 ₁ 5 _: c]pyridm-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to a suspension of methyl 3-[4-[2- methoxy ethyl (methyl)amino]anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.17 mmol) in MeOH (10 mL). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 5-20% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[2- methoxy ethyl (methyl)amino]anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7- yl)pyrazine-2-carboxamide (32 mg, 41%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.88 - 2.97 (6H, m), 3.29 (3H, s), 3.44 - 3.52 (4H, m), 4.02 (3H, s), 6.73 (2H, d), 7.29 (1H, s), 7.60 (2H, d), 7.70 (1H, s), 8.00 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.19

(1H, s); m/z: (ES+), [M+H]+ = 462.2 Example 95

3-r4-rBis(2-methoxyethvnamino1anilino1-5-(methylamino)-6- (3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide

(a) _. Methyl J _. :X4 _r [bis(2-methoxyethyl)aminolanilino]-5 ₇ (methylarnino)-6-(3- i??et¼llll3kdazp£4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-bromo-N,N-bis(2-methoxyethyl)aniline (184 mg, 0.640 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, to afford methyl 3-[4-[bis(2-methoxyethyl)amino]anilino]-5-(methylamino)-6-(3 - methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.040 g, 24%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.89 (3H, d), 3.24 - 3.30 (6H, m), 3.44 - 3.52 (8H, m), 3.81 (3H, s), 4.01 (3H, s), 6.71 (2H, d), 7.54 - 7.61 (2H, m), 7.91 (1H, br q), 8.49 (1H, s), 8.54 (1H, s), 9.02 (1H, s), 10.16 (1H, s); m/z\ (ES+), [M+H]+ = 521.2 {b).3-[4 ₇ lBis{2 _: methox _j .ethyl)amino]anilino]-5 _: (methylaminoJ-6-(3-methylimidazo[4 ₃ 5- c]pyridin:7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[4-[bis(2- methoxyethyl)amino]anilino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (30 mg, 0.06 mmol). The resulting suspension was stirred at 80 °C for 30 hours. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, 20-30% MeClNMhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[bis(2-methoxyethyl)amino]anilino]-5-(methylamino)-6-(3 - methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (13 mg, 45% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.93 (3H, d), 3.35 (6H, s), 3.48 (8H, s), 4.01 (3H, s), 6.71 (2H, d), 7.27 (1H, s), 7.57 (2H, d), 7.68 (1H, s), 8.00 (1H, br q), 8.51 (1H, s), 8.72 (1H, s), 9.00 (1H, s), 11.17 (1H, s). m/z\ (ES+), [M+2H] ²⁺ = 253.8

Example 96

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r (2-methyl-4- pyridvDaminolpyrazine-2-carboxamide formate salt

(a).. Methyl.5:_(m_ethy]_ami_nq)-6 _: (_3-m_et_hyJ_im_i_d_azoL4,5_-cJpyndi_n-7:y!).:3-[(2_-m ethy]_-4 _: pyri dyl jam i_ n p]py r azi n e _: 2 - carb ox y ] ate

XantPhos (611 mg, 1.06 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (110 mg, 0.35 mmol), 4-bromo-2-methyl-pyridine (61 mg, 0.35 mmol), and cesium carbonate (11.5 mg, 0.0400 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 7 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(2 -methyl-4- pyridyl)amino]pyrazine-2-carboxylate (0.080 g, 56%) as a brown solid; 1H NMR (300 MHz,

DMSO-d6) d 2.45 (3H, s), 2.98 (3H, d), 3.85 (3H, s), 4.02 (3H, s), 7.68 (1H, s), 7.74 (1H, s), 8.01 (1H, br q), 8.31 (1H, d), 8.52 (2H, d), 9.08 (1H, s), 10.61 (1H, s); m/z: (ES+), [M+H]+ =

405.1

{¾ _. 5rXMethyJamino):6-(3-methylimidazq[4,5-cJp _j ridin _: 7-yl)-3 _: [(2-methyl-4- pyridyl) _. aining]pyrazine:2_-carboxamide formate _, salt

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(2-methyl-4-pyridyl)ami no]pyrazine-2-carboxylate (60 mg, 0.15 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Sunfire prep C18 column, 2-25 % MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(2 -methyl- 4-pyridyl)amino]pyrazine-2-carboxamide formate salt (20 mg, 32%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.44 (3H, s), 3.00 (3H, d), 4.02 (3H, s), 7.51 (1H, s), 7.59-7.64 (1H, m), 7.65-7.70 (1H, m), 7.85 (1H, s), 8.05 (1H, br q), 8.18 (1H, br s), 8.28 (1H, d), 8.53 (1H, s), 8.73 (1H, s), 9.05 (1H, s), 11.79 (1H, s); m/z: (ES+), [M+H]+ = 390.1 Example 97

3-r(2-Methoxy-4-pyridvnamino1-5-(methylamino)-6-(3-methyl imidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

{4)M?thyl 3 _: £(2-methgxy-4 _: pyridyl)amino]-5 _: (methylaminc)) _: 6-(3-methylimidazo[4,5- c]pyridin _: 7 _: yljpyrazine-2 _: carbgxylate

Brettphos Pd G3 (44 mg, 0.050 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (150 mg, 0.48 mmol), 4-bromo-2-methoxy-pyridine (135 mg, 0.720 mmol) and cesium carbonate (469 mg, 1.44 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was diluted with MeOH and filtered through celite. The resulting filtrate was concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford methyl 3-[(2-methoxy-4-pyridyl)amino]-5-(methylamino)-6-(3-methylim idazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.115 g, 57% yield) as a yellow solid, m z: (ES+), [M+H]+ = 421.2.

{¾ _. 3-[(2-Methpx _j. :4-p _j ridyl)aminoJ-5-(methylaminp)-6-(3-methyhmidazo^4,5-c] _^ pyridin-7- yljpyrazine-2 _: carbpxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[(2-methoxy-4- pyridyl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxylate (80 mg, 0.19 mmol). The resulting suspension was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD C18 Column, 12%-42% MeCN-TLO as eluent, and 0.1% ammonia as a modifier, to afford 3-[(2-methoxy-4-pyridyl)amino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (0.019 g, 25%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.96 (3H, d), 3.83 (3H, s), 4.00 (3H, s), 7.03-7.09 (1H, m), 7.49 (1H, s), 7.52-7.56 (1H, m), 7.84 (1H, s), 7.99 (1H, d), 8.05 (1H, br q), 8.53 (1H, s), 8.72 (1H, s), 9.05 (1H, s), 11.84 (1H, s); m/z: (ES+), [M+H]+ = 406.1.

Example 98

3-r(2-Methoxy-6-methyl-4-pyridvnaminol-5-(methylamino)-6- (7-methylimidazor4.5- clpyridazin-4-vDpyrazine-2-carboxamide hydrochloride

(a) _. Methyl _. 6 _r chloro-3-[(2 _: methqxy _: 6-methyl-4 _T pyridylJamjnp]^5 _: (methylaminoJpyrazine-2 _: carbpxylate A mixture of methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (0.309 g, 1.43 mmol), 4-bromo-2-methoxy-6-methyl-pyridine (0.472 g, 2.34 mmol), t-BuXPhos Pd G3 (0.113 g, 0.140 mmol), t-BuXPhos (0.061 g, 0.14 mmol), and sodium tert-butoxide (0.274 g, 2.85 mmol) in THF (12 mL) was evacuated and backfilled three times with nitrogen. The resulting mixture was stirred at 40 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[(2-methoxy-6-methyl-4-pyridyl)amino]-5- (methylamino)pyrazine-2-carboxylate (0.512 g, 106%) as a brown solid z: (ES-), [M-H]- = 336.3

{b) _. 6-Chl ro-3-L(2 _: methpx _j.: 6-rnethyl-4 _: pyridyl)amino]-5 _: (methylaminoJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 6-chloro-3-[(2-methoxy-6- methyl-4-pyridyl)amino]-5-(methylamino)pyrazine-2-carboxylat e (0.387 g, 1.15 mmol). The resulting suspension was stirred at 100 °C for 5.5 hours. The reaction was then concentrated. The resulting residue was triturated in EtOAc. The resulting suspension was filtered. The resulting filtrate was concentrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent, to afford 6-chloro-3-[(2-methoxy-6- methyl-4-pyridyl)amino]-5-(methylamino)pyrazine-2-carboxamid e (0.247 g, 67%) as a yellow solid m/z: (ES+), [M+H]+ = 323.1

{c) _. 3:b(2rMethox _. :6-methyl-4-pyrid _j J)amino]-5-(inethylamino):6-(7-methylimidazo[4,5- c]p ridazin-4 _: yl)_pyrazine-2-carboxamide hydrochloride A mixture of 4-chloro-7-methyl-imidazo[4,5-c]pyridazine (0.037 g, 0.22 mmol), bis(pinacolato)diboron (0.084 g, 0.33 mmol), potassium acetate (0.065 g, 0.66 mmol), cataCXium A Pd G3 (0.016 g, 0.020 mmol) and cataCXium A (7.9 mg, 0.020 mmol) in DMF (2.0 mL) was evacuated and backfilled three times with nitrogen. The resulting mixture was stirred at 100 °C for 18.5 hours. The reaction was then allowed to cool to room temperature and set aside.

6-Chloro-3-[(2-methoxy-6-methyl-4-pyridyl)amino]-5-(methy lamino)pyrazine-2- carboxamide (0.050 g, 0.15 mmol), PdCh(dppf) (0.011 g, 0.020 mmol), and cesium fluoride (0.071 g, 0.46 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent. The resulting material was further purified by basic alumina chromatography, using 0 to 5% MeOH-DCM as eluent. The resulting material was taken up in methanol, treated with IN HC1 (20 uL), and then concentrated to affford 3-[(2-methoxy-6- methyl-4-pyridyl)amino]-5-(methylamino)-6-(7-methylimidazo[4 ,5-c]pyridazin-4- yl)pyrazine-2-carboxamide hydrochloride (4.0 mg, 5.7%) as an orange solid; lH NMR

(500MHz, DMSO-d6) 2.44 (3H, br s), 3.08 (3H, d), 4.01 (3H, br s), 4.06 (3H, s), 7.23 (1H, br s), 7.72 - 7.84 (2H, m), 8.30 (1H, br s), 8.91 (1H, s), 9.47 (1H, br s), 9.85 (1H, s), 12.51 (1H, br s). m/z: (ES+), [M+H]+ = 421.2

Example 99

3-r(2.6-Dimethyl-4-pyridvnamino1-5-(methylamino)-6-(3-met hylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide {a)Methy) _. J _. :£(2 _J 6-dimethyl:4-pyridylJaminoJ:5-(methylamino)-6:(3:methy limidazg[4 _i 5: c]pyridm-7 _: yljpyrazine-2 _: carbpxylate

Methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (120 mg, 0.38 mmol) was added to a mixture of 4-bromo-2, 6-dimethyl-pyridine (143 mg, 0.770 mmol), cesium carbonate (374 mg, 1.15 mmol), and BrettPhos Pd G3 (35 mg, 0.040 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3 -[(2,6- dimethyl -4-pyridyl)amino]-5-(methylamino)-6-(3 -methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.080 g, 50%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) s), 8.53 (1H, s), 9.01 (1H, s), 9.07 (1H, s); m/z: (ES+), [M+H]+ = 419.2

£bJ.l-I(2,6-Dimethyl _: 4 _r pyridyJJaminp] _: 5.-XmethyJamino)-6. _: £3 _: methyHmidazp[4 ₁ 5 _: .c]pyridin.-7 _: yJjpyrazine-2 _T carbpxarnide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[(2,6-dimethyl-4- pyridyl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxylate (80 mg, 0.19 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Sunfire prep C18 column, 2-20% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 3-[(2,6-dimethyl-4-pyridyl)amino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (21 mg, 25%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.39 (6H, s), 3.00 (3H, d), 4.02 (3H, s), 7.50 (2H, s), 7.84 (1H, s), 8.06 (1H, br q), 8.21 (1H, s), 8.53 (1H, s), 8.73 (1H, s), 9.05 (1H, s), 11.72 (1H, s); m/z: (ES+), [M+H]+ = 404.2

Example 100

5-Cvclopropyl-3-r(2.6-dimethyl-4-pyridvDamino1-6-(3-methy limidazor4.5-c1pyridin-7-

_(a)_ Methyl .5 rcyclppropy 1-3 _: £(2 _a 6-dimethyl -4 _: pyri dy l)aminql-6-(3 -methy limi dazpJykS _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylate

Methyl 3-amino-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine-2- carboxylate (100 mg, 0.31 mmol), 4-bromo-2, 6-dimethyl-pyridine (69 mg, 0.37 mmol), BrettPhos Pd G3 (28 mg, 0.030 mmol), and cesium carbonate (301 mg, 0.920 mmol) were combined in a microwave vial, which was evacuated and backfilled with nitrogen three times. 1,4-Dioxane (3.1 mL) was added. The resulting mixture was stirred at 110 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM with 0-1% ammonia as eluent, to afford methyl 5-cyclopropyl-3-[(2, 6-dimethyl -4-pyridyl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.074 g, 56%); 1H NMR (500 MHz, CHLOROFORM-d) d .02 - 1.15 (2H, m), 1.32 - 1.41 (2H, m), 1.98 - 2.07 (1H, m), 2.54 (6H, s), 3.99 (3H, s), 4.01 (3H, s), 7.38 (2H, s), 8.02 (1H, s), 8.69 (1H, s), 8.93 (1H, s), 10.47 (1H, br s); m/r. (ES+), [M+H]+ = 430.2

{¾ _. 5rCycloprgpyl-3 _: ^(2 ₃ _6-dj _. methyl-4 _: pyridyl)aminp] _.: 6-(3 _: methy_limidazp^4 ₁ 5 _: c] _. pyridin-7 _: y _. URyra?ine _. -2 _: carbpxamide 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to a solution of methyl 5- cyclopropyl-3-[(2,6-dimethyl-4-pyridyl)amino]-6-(3-methylimi dazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (74 mg, 0.17 mmol) in methanol (1.5 mL). The resulting solution was stirred at 100 °C for 4 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 0-1% ammonia as modifier, to afford 5-cyclopropyl-3-[(2,6- dimethyl-4-pyridyl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxamide (32 mg, 45%) as a yellow solid; 1HNMR (500 MHz, CHLOROFORM-d) d 1.00 - 1.14 (2H, m), 1.33 - 1.43 (2H, m), 2.02 - 2.11 (1H, m), 2.53 (6H, s), 4.03 (3H, s), 5.65 (1H, br s), 7.39 (2H, s), 7.91 (1H, br s), 8.04 (1H, s), 8.66 (1H, s), 8.94 (1H, s), 11.13 (1H, br s); m/z\ (ES+), [M+H]+ = 415.2

Example 101

3-r(2-Methoxy-6-methyl-4-pyridvnaminol-5-(methylamino)-6- (3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide

{4) _. 3:K2rMethpxy _. :6-methyl-4-pyridyJ)aminp]-5-(methylaminp):6-(3-methyl imidazp[4,5- c]pyridin-7 _: yljpyrazine-2 _: carbpxylic.acid

A mixture of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (45 mg, 0.14 mmol), 4-bromo-2-methoxy-6-methyl-pyridine (35 mg, 0.17 mmol), BrettPhos Pd G3 (13 mg, 0.010 mmol), and sodium tert-butoxide (41 mg, 0.43 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (1.5 mL) was added, and the mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was acidified with IN aqueous HC1, then washed with ethyl acetate. The aqueous layer was then concentrated. The resulting residue was used in the next step without further purification, assuming 100% yield

_. (bJ _. 3rI(2-Methoxy _. :6-methyl-4 _: pyridyl)amino]-5 ₇ (iTiethylarnino)-6-(3-rnethyliniidazo[4 _J 5- c]pyridin _: 7 _: ylJpyrazine-2 _: carboxamide

DIPEA (0.150 mL, 0.86 mmol) was added to a suspension of S-f^-methoxy-e-methyM- pyridy^aminoJ-S^methylamino^e-p-methylimidazol^fS-cJpyridin^ -y^pyrazine^- carboxylic acid (60 mg, 0.14 mmol), ammonium chloride (31 mg, 0.57 mmol), and HATU (109 mg, 0.290 mmol) in DMF (2 mL). The resulting mixture was stirred at 25 °C for 1 hour, The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford a yellow solid. This material was further purified by reverse phase HPLC, using a 5 micron, 19 mm x 100 mm Xbridge C18 column, 13-40% MeCN-FfO as eluent, and 0.1% trifluoroacetic acid as modifier, to afford 3-[(2-methoxy-6-methyl-4-pyridyl)amino]-5-(methylamino)-6-(3 -methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (0.024 g, 32%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d ppm 2.42 (3H, s), 2.99 (3H, d), 3.96 (3H, s), 4.12 (3H, s), 7.12 (1H, br d), 7.69 (2H, br s), 7.89 (1H, br d), 8.03 (1H, br s), 8.93 (2H, s), 9.46 (1H, s), 12.22 (1H, br d). m/r. (ES+), [M+H]+ = 420.3

Example 102

3-rr2-(2-Methoxyethoxy)-6-methyl-4-pyridyllaminol-5-(meth ylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

£4) _.. 4:Brqmo-2-(2_-m_ethoxy_ethqxyJ _: 6-rnethy]-p_yri_di_ne DTBAD (3.67 g, 16.0 mmol) was added to a mixture of 4-bromo-6-methyl-pyridin-2-ol (2.00 g, 10.6 mmol), 2-methoxyethanol (1.21 g, 16.0 mmol), and triphenylphosphine (4.18 g, 15.96 mmol) in THF (50 mL) under nitrogen. The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-60% MeCN-FbO as eluent and 0.1% formic acid as modifer, to afford 4-bromo-2-(2-methoxyethoxy)-6-methyl-pyridine (1.40 g, 54%) as a yellow oil which crystallized on standing; 1H NMR (400 MHz, DMSO-d6) d 2.36 (3H, s), 3.28 (3H, s), 3.59 - 3.66 (2H, m), 4.32 - 4.39 (2H, m), 6.91 (1H, m), 7.10 (1H, m); m/z:

(ES+), [M+H]+ = 246.0

{b).Methyl.3_-[j/2-(2_-methpxyethoxy.)-6-m_ethyl-4 _: pyri_dylJamin_o]. _: 5-(m_ethylamino)-6 _: (_3- methyHmid^p£4 _^ 5 _r c]pyridin-7 _r ylJpyr^ine-2 _r c^bpxylate

Brettphos Pd G3 (74 mg, 0.080 mmol) was added to a suspension of 4-bromo-2-(2- methoxyethoxy)-6-methyl-pyridine (100 mg, 0.41 mmol), methyl 3-amino-5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (127 mg, 0.410 mmol), and cesium carbonate (265 mg, 0.810 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[[2-(2-m ethoxy ethoxy)-6-methyl-4-pyridyl]amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.080 g, 41%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.35 (3H, s), 2.95 (3H, d), 3.33 (3H, s), 3.74 (2H, s), 3.84 (3H, s), 4.00 (2H, s), 4.01 (3H, s), 7.15 (1H, d), 7.28 (1H, d), 8.03 (1H, d), 8.46 (1H, d), 8.53 (1H, s), 9.06 (1H, s), 10.59 (1H, s); m/z: (ES+), [M+H]+ = 479.2 {c).3:^[2-(2-Methpxyethox _j J-6 _: methyl _: 4 _r pyri_dylJaminoJ _: 5_-(methylamino)-6 _: _(3_ _: methyhmidazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-[[2-(2-methoxyethoxy)- 6-methyl-4-pyridyl]amino]-5-(methylamino)-6-(3-methylimidazo [4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (50 mg, 0.10 mmol). The resulting suspension was stirred at 80 °C for 15 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Xselect CSH OBD column, 5-25% MeCN- H2O as eluent, and 0.1% formic acid as modifier, to afford 3-[[2-(2-methoxyethoxy)-6- methyl-4-pyridyl]amino]-5-(methylamino)-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine- 2-carboxamide (18 mg, 37%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.32 (3H, s), 2.96 (3H, d), 3.58 - 3.67 (2H, m), 4.00 (3H, s), 4.29 - 4.38 (2H, m), 7.02 (1H, s), 7.26 (1H, d), 7.50 (1H, s), 7.84 (1H, s), 8.03 (1H, br q), 8.51 (1H, s), 8.71 (1H, s), 9.03 (1H, s),

11.78 (1H, s). The ethereal methyl group was obscured by the residual water peak; m/z:

(ES+), [M+H]+ = 464.2 Example 103

3-r(2-Cvano-6-methyl-4-pyridvDamino1-5-(rnethylarnino)-6- (3-methylirnidazc>r4.5-c1pyridin-

7-vDpyrazine-2-carboxamide

{aXS-Amino _j S-XmeAyl^jnp^b^-metihyHmid^p^S-cJpyridin-T _j ylJpyrazine-?.: carboxamide

A mixture of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (46 mg, 0.15 mmol) and lithium hydroxide (27.0 mg, 1.13 mmol) in water (0.5 mL), MeOH (0.5 mL), and THF (0.5 mL) was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction mixture was then acidified with 1 N HC1 and concentrated. The resulting residue was dissolved in DMF (1.5 mL). HATU (0.086 g, 0.23 mmol), ammonium chloride (0.040 g, 0.75 mmol), and triethylamine (84 μL, 0.60 mmol) were sequentially added. The resulting mixture was stirred at 25 C for 3 hours. Additional triethylamine (150 μL, 1.07 mmol) was added. The resulting mixture was stirred at 25 C for 16 hours. The reaction then was treated with saturated aqueous sodium bicarbonate. The resulting suspension was filtered. The filtrate was extracted with 5:1 DCM/IPA. The organic layer was washed with brine dried over magnesium sulfate, filtered, and concentrated to afford 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxamide (0.045 g, quantitative ⁰ /! ₎ ) as a brown solid, m z: (ES+), [M+H]+ = 299.1 {¾ _. 3-[(2-Cyano _: 6-methyl-4 _: pyridyl)amino]-5 _: (^methylamino)-6-(3-methylimidazq[4,5- c]pyridin-7 _r yl)pyrazine-2 _: carbqxamide

A mixture of 4-bromo-6-methyl-pyridine-2-carbonitrile (0.035 g, 0.18 mmol), 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (0.045 g, 0.15 mmol), BrettPhos Pd G3 (0.027 g, 0.030 mmol), and cesium carbonate (0.147 g, 0.450 mmol) in 1,4-dioxane (2 mL) was evacuated and backfilled with nitrogen 3 times. The resulting mixture was stirred at 100 °C for 16 hours. The reaction mixture was then treated with water and filtered. The filter cake was washed with water, dried under vacuum, and purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford a yellow solid. This material was further purified by Cl 8 reverse phase chromatography, using 0-30% MeCN-FbO as eluent and 0.1% trifluoroacetic acid as modifier, to afford 3-[(2-cyano-6-methyl-4- pyridyl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxamide (5.0 mg, 7.4%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.99 (3H, d), 4.06 (3H, s), 7.07 (1H, t), 7.63 (1H, br s), 7.86 (1H, d), 7.95 (1H, s), 8.00 (1H, br s), 8.40 (1H, d), 8.76 (1H, br s), 8.84 (1H, s), 9.28 (1H, br s), 12.09 (1H, s); the aryl methyl group was buried under the DMSO signal; m/z: (ES+), [M+H]+ = 415.1 Example 104

3-r(1.5-Dimethyl-6-oxo-3-pyridvnamino1-5-(methylamino)-6- (3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide

{4} _. 3:I(-L5 _. -Dimethyl-6-oxo-3 _. -pyridylJaminp] _. :5-(methylamino)-6:(3-methylimidazo[4 _i 5- A mixture of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (45 mg, 0.14 mmol), 5-bromo-l,3-dimethyl-pyridin-2-one (35 mg, 0.17 mmol), BrettPhos Pd G3 (13.02 mg, 0.01 mmol) and sodium tert-butoxide (41.4 mg, 0.43 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (1.5 mL) was added, and the mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was acidified with IN aqueous HC1, then washed with ethyl acetate. The aqueous layer was then concentrated. The resulting residue was used in the next step without further purification, assuming 100% yield.

{bi _. S-tCLS-Dimethyke-oxpG-pyridylJaminoJ^S-imethylaminq^e^ S^methyhmidazq^S: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

DIPEA (0.15 mL, 0.86 mmol) was added to a suspension of of 3-[(l,5-dimethyl-6-oxo-3- pyridyl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxylic acid (60 mg, 0.14 mmol), ammonium chloride (31 mg, 0.57 mmol), and HATU (109 mg, 0.290 mmol) in DMF (2 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford a yellow solid. This material was further purified by reverse phase HPLC, using a 19 mm x 100 mm 5pm Xbridge C18 column, using 13-40% MeCN-FbO as eluent and 0.1% trifluoroacetic acid as modifier, to afford 3-[(l,5-dimethyl-6-oxo-3-pyridyl)amino]-5-(methylamino)-6-(3 -methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (3.3 mg, 5.5%) as a light yellow solid; 1HNMR (500 MHz, DMSO-d6) d 2.40 (3H, s), 2.97 (3H, d), 3.94 (3H, s), 4.10 (3H, s), 7.11 (1H, br s), 7.67 (2H, br s), 7.83 - 7.94 (1H, m), 8.01 (1H, br s), 8.91 (2H, s), 9.44 (1H, s), 12.21 (1H, br s); m/r. (ES+), [M+H]+ = 420.3

Example 105

3-rri-(Difluoromethvn-6-oxo-3-pyridyl1amino1-5-(methylami no)-6-(3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide

(a) Methyl :I [1 ridifluorpmethy l)-6-oxp-3 _: p_yridy ljaminp]. _: 5 -(methyl amino)-6 _: (3- metMh.ll3idazp£4 ₁ 5 _: c]pyridin-7 _: yl_)pyrazine-2 _: carboxylate

Cesium carbonate (312 mg, 0.960 mmol) was added to a suspension of 5-bromo-l- (difluoromethyl)pyridin-2-one (143 mg, 0.640 mmol), BrettPhos Pd G3 (29 mg, 0.030 mmol), and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[[l-(difluoromethyl)-6-oxo-3-pyridyl]amino]-5-(methylamino )-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.060 g, 41%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.84 (3H, d), 3.81 (3H, s), 3.99 (3H, s), 6.53-6.61 (1H, m), 7.73-7.81 (1H, m), 7.91 (1H, t), 7.96 (1H, br q), 8.48 (1H, s), 8.51 (1H, s), 8.63-8.70 (1H, m),

9.03 (1H, s), 9.96 (1H, s); m/z: (ES+), [M+H]+ = 457.2 {¾ _. 3-[y-(Diflugromethyl)-6-oxp:3-pyridylJaminpJ:5-(methyl amino)-6:(3: methyhmMazg[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carbpxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[[l-(difluoromethyl)-6- oxo-3-pyridyl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxylate (60 mg, 0.13 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 19 x 250 mm XSelect CSH Prep C18 OBD column, 15-35% MeCN-LLO as eluent, and 0.1% formic acid as modifier, to afford 3-[[l-(difluoromethyl)-6-oxo-3- pyridyl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxamide (8.0 mg, 14%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.92 (3H, d), 4.02 (3H, s), 6.58 (1H, d), 7.43 (1H, s), 7.67 (1H, m), 7.79 (1H, s), 7.94 (1H, t), 8.08 (1H, br q), 8.53 (1H, s), 8.73 (1H, s), 8.83 (1H, d), 9.04 (1H, s), 11.20 (1H, s); m/z: (ES+), [M+H]+ = 442.1

Example 106

5-(Methylamino)-3-r4-rnR.4R)-5-methyl-2.5-diazabicvclor2. 2.11heptan-2-yllanilinol-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide bis-formate salt

(^XlR _j fiR^rHrBjompphenjJ^-S-methyl^S-diazabicycloLZlJJheptan e Cesium carbonate (2.30 g, 7.07 mmol) was added to a mixture of l-bromo-4-iodo-benzene (500 mg, 1.77 mmol), (lR,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (393 mg, 2.12 mmol), palladium(II) acetate (40 mg, 0.18 mmol), and (rac)-BINAP (110 mg, 0.18 mmol) in 1,4-dioxane (15 mL). The resulting mixture was stirred at 80°C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford (lR,4R)-2-(4-bromophenyl)- 5-methyl-2,5-diazabicyclo[2.2.1]heptane (0.200 g, 42%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.74 (1H, ddt), 1.86 (1H, ddt), 2.24 (3H, s), 2.43 (1H, dd), 2.76 (1H, dd), 3.10 (1H, dd), 3.28 (1H, dd), 3.41 (1H, d), 4.26 (1H, d), 6.48 - 6.59 (2H, m), 7.22- 7.31 (2H, m). m/z\ (ES+), [M+2+H]+ = 269.0

£bJ.Methyl 5_-(m_et_hyJ_ami_no)_-3 _: £4 _: £(l R ₁ 4R)-5-met_hyJ_-2 _J _5-di_azabi_cydo[2,2,_lJhep_tan _: _2- ylJandinpJ^-XS-methylimidazotfl _^ S-cJpyndin^^^yJJpyrazine-^-carboxylate BrettPhos Pd G3 (23 mg, 0.030 mmol) was added to a suspension of cesium carbonate (250 mg, 0.77 mmol), (lR,4R)-2-(4-bromophenyl)-5-methyl-2,5-diazabicyclo[2.2.1]he ptane (136 mg, 0.510 mmol) and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.26 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-3-[4-[(lR,4R)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl]anilino]-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-2- carboxylate (0.060 g, 47%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.90 (1H, d), 2.00 (2H, s), 2.43 - 2.49 (3H, m), 2.89 (4H, d), 3.22 (1H, d), 3.45 (1H, d), 3.70 - 3.78 (1H, m), 3.82 (3H, s), 4.02 (3H, d), 4.40 (1H, s), 6.64 (2H, d), 7.57 - 7.66 (2H, m), 7.91 (1H, d), 8.50 (1H, s), 8.54 (1H, s) 9.03 (1H, s), 10.20 (1H, s). m/r. (ES+), [M+2H] ²⁺ = 250.6 (cj.S^M^ethylamjnp^SJfl^lR _^ flRX-S^methyE^ _^ ^-dmzabicyclof^.Z^Jheptan-^-ylJanilinol-e: _. (3 _.T niethyJirn!dazoL4,5 _T c]pyridin-7:yJ)pyrazine-2:Carbpxamide bis-fprmate salt 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-(methylamino)-3-[4- [(lR,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino ]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The resulting residue was purified by preparative HPLC Column, using a 5 micron, 19 mm x 250 mm, XBridge Prep OBD C18 column, 15-35% MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-3-[4- [(lR,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino ]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt (9.0 mg, 13%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.75-1.83 (1H, m), 1.86-1.95 (1H, m), 2.32 (3H, s), 2.52-2.66 (1H, m), 2.76-2.86 (1H, m), 2.93 (3H, d), 3.11-3.20 (1H, m), 3.31-3.40 (1H, m), 3.50 (1H, s), 4.02 (3H, s), 4.29 (1H, s), 6.60 (2H, d), 7.28 (1H, s), 7.59 (2H, d), 7.69 (1H, s), 8.00 (1H, br q), 8.23 (2H, s), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.18 (1H, s); m/z\ (ES+), [M+2H] ²⁺ = 243.1

Example 107

5-(Methylamino)-3-r4-(8-methyl-3.8-diazabicvclc>r3.2.1 1octan-3-vDanilino1-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

_. (aJ _. 3 _. ri4:Bromophenyl)-8-methyl-3,8-diazabicycloL3.2,jJoctan e l-Bromo-4-iodo-benzene (500 mg, 1.77 mmol) was added to a mixture of 8-methyl-3,8- diazabicyclo[3.2.1]octane hydrochloride (287 mg, 1.77 mmol), cesium carbonate (1.73 g, 5.30 mmol), (rac)-BINAP (165 mg, 0.27 mmol), and palladium(II) acetate (60 mg, 0.27 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford 3 -(4-bromophenyl)-8-m ethyl- 3, 8-diazabicyclo[3.2. ljoctane (0.200 g, 40%) as a yellow solid; 1H NMR (400 MHz, DMSO- d6) d 1.68 (2H, d), 1.99 (2H, dd), 2.35 (3H, s), 2.82 - 2.97 (2H, m), 3.30-3.45 (4H, m), 6.73 -

6.82 (2H, m), 7.27 - 7.35 (2H, m); m/z: (ES+), [M+H]+ = 281.0

{b).Methyl.5-(methylamino)-3 _: J^4 _: (8-methyl-3 _: 8-diazabicyclp33 _; 2.Uoctan _: 3-yl)anilino]-6 _: i_3- methyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

3-(4-Bromophenyl)-8-methyl-3,8-diazabicyclo[3.2. ljoctane (90 mg, 0.32 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol), BrettPhos Pd G3 (43 mg, 0.050 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-3-[4-(8-methyl-3,8-diazabicyclo[3.2. l]octan-3-yl)anilino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.060 g, 37%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.97 - 1.99 (2H, m), 2.05 - 2.09 (2H, m), 2.90 (3H, d), 2.96 - 3.01 (2H, m), 3.10 - 3.22 (2H, m), 3.38 - 3.60 (2H, m), 3.82 (3H, s), 4.02 (3H, s), 6.90 (2H, d), 7.66 (2H, d), 7.90 (1H, br q), 8.50 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.25 (1H, s); the tertiary NMe peak was obscured under the DMSO peak; m z: (ES+), [M+H]+ = 514.2 {c) _. 5:{Methylaminp)-3 :X4-(8 _: methyl _: 3 ₃ 8-dj _. azabicyclo[3.2. lJoctan-3 -yl)anilino]-6:(3 : .biethyJi rnjdazo^ _^ ii :_c]pyri din- 7 _: yjjpy razjn e-2 _: _carb ox am ide

7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-3-[4-(8- methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)anilino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (50 mg, 0.10 mmol). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep OBD C18 column, 23- 33% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-3-[4-(8-methyl-3,8- diazabicyclo[3.2.1]octan-3-yl)anilino]-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxamide (9.0 mg, 19%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.60 - 1.70 (2H, m), 1.89 - 2.00 (2H, m), 2.23 (3H, s), 2.80 (2H, dd), 2.93 (3H, d), 3.20 (2H, s), 3.29 (2H, s), 4.02 (3H, s), 6.81 (2H, d), 7.30 (1H, s), 7.61 (2H, d), 7.70 (1H, s), 7.99 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.23 (1H, s); m/z\ (ES+), [M+H]+ = 499.3

Example 108 3-r4-r(3S.5R)-3.5-Dimethylpiperazin-l-yl1anilino1-6-(3-methy limidazor4.5-c1pyridin-7-vD-5-

(trifluoromethvDpyrazine-2-carboxamide

_. (aJdj-S^Rj- l-dd-BromophenyJj-j^-dimethyhpiperazine

Dioxane (15 mL) was added to a mixture of l-bromo-4-iodo-benzene (0.580 g, 2.05 mmol), (2R,6S)-2,6-dimethylpiperazine (0.351 g, 3.08 mmol), palladium(II) acetate (0.046 g, 0.21 mmol), XantPhos (0.237 g, 0.41 mmol) and sodium tert-butoxide (0.296 g, 3.08 mmol). The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 90 °C for 6 hours. The reaction was then diluted with water and extracted with 5:1 DCM/IPA. The organic layer was concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford (3S,5R)-l-(4-bromophenyl)- 3, 5 -dimethyl -piperazine (0.372 g, 67%) as a brown solid; 1H NMR (500MHz, DMSO-d6) d 1.00 (6H, d), 2.08 (2H, t), 2.80 (2H, dqd), 3.16 (1H, s), 3.49 (2H, dd), 6.82 - 6.90 (2H, m),

7.25 - 7.34 (2H, m). m/r (ES+), [M+2+H]+ = 271.1

£bJ.3_-[4_-£(_3_S ₁ 5RJ-3 _J 5-Dim_e_thyJ_p_i_perazin_-l -yQani_lin_o2 _: 6-(3-methyJj.rnidazo£4 ₁ 5-c]_pyri_di_n-7- yD:5^(trifluoromethylJpyrazine-2 _: carbpxylic acid

Dioxane (1 mL) was added to a mixture of (3S,5R)-l-(4-bromophenyl)-3, 5-dimethyl- piperazine (0.037 g, 0.14 mmol), ethyl 3-amino-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-5- (trifluoromethyl)pyrazine-2-carboxylate (0.042 g, 0.11 mmol), BrettPhos Pd G3 (0.021 g, 0.020 mmol), and cesium carbonate (0.112 g, 0.340 mmol). The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 100 °C for 2.5 hours. The reaction was then concentrated. The resulting residue was treated with water and extracted with EtOAc. The aqueous layer was acidified to pH 3 with 1M HC1, then concentrated to afford 3-[4-[(3S,5R)-3,5-dimethylpiperazin-l-yl]anilino]-6-(3-methy limidazo[4,5-c]pyridin- 7-yl)-5-(trifluoromethyl)pyrazine-2-carboxylic acid (0.060 g, 99 %), which was used in the next step without purification.

{c).3:b4:b(3S _J 5R) _: 3,5-Dimethylpiper^in _: l-yl]anilino]-6 _: (3 _: methylimidazg[.4 ₁ 5 _: c]pyridin-7 _: y]J:5^(triflupromethyl_)pyrazine-2 _: carbpxamide

Triethylamine (0.061 mL, 0.44 mmol) was added to a suspension of of 3-((4-((3S,5R)-3,5- dimethylpiperazin-l-yl)phenyl)amino)-6-(3-methyl-3H-imidazo[ 4,5-c]pyridin-7-yl)-5- (trifluoromethyl)pyrazine-2-carboxylic acid (0.058 g, 0.11 mmol), ammonium chloride (0.029 g, 0.55 mmol) and HATE! (0.063 g, 0.17 mmol) in DMF (1.5 mL). The resulting mixture was stirred at 25 °C overnight. The reaction was treated with saturated aqueous sodium bicarbonate and extracted with 5: 1 DCM/IPA. The organic layer was concentrated. The resulting residue was purified by C18 reverse phase chromatography, using 0-55% MeCN- H2O as eluent and 0.1% ammonium hydroxide as modifier, to afford 3-((4-((3S,5R)-3,5- dimethylpiperazin-l-yl)phenyl)amino)-6-(3-methyl-3H-imidazo[ 4,5-c]pyridin-7-yl)-5- (trifluoromethyl)pyrazine-2-carboxamide (0.018 g, 31%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 5 1.15 (6H, br d), 2.31 - 2.43 (2H, m), 3.07 - 3.19 (2H, m), 3.70 (2H, br d), 3.99 (3H, s), 7.02 (2H, br d), 7.62 (2H, br d), 8.14 (1H, br d), 8.27 (1H, s), 8.40 (1H, s), 8.44 (1H, s), 9.05 (1H, s), 11.28 (1H, s). m/r (ES+), [M+H]+ = 526.3 Example 109

3-r4-r(3S.5R)-3.5-Dimethylpiperazin-l-yl1-3.5-difluoro-an ilino1-5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide iaJdj _. S^Rj-l-dd-Bronio-^^^difluoro-phenylj _TJ .S-dii _Ti ethyl-piperazine Pd ₂ (dba) ₃ (288 mg, 0.320 mmol) was added to a suspension of 5-bromo-l,3-difluoro-2- iodobenzene (1.0 g, 3.14 mmol), c/s-2,6-dimethylpiperazine (394 mg, 3.44 mmol), Xantphos (362 mg, 0.620 mmol), and cesium carbonate (2.04 g, 6.28 mmol) in dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford (3S,5R)-l-(4-bromo-2,6-difluoro-phenyl)-3, 5-dimethyl- piperazine (0.300 g, 31%) as a brown oil; 1H NMR (400 MHz, DMSO-d6) d 0.95 (6H, d), 2.58 (2H, t), 2.75 - 2.90 (2H, m), 2.98 (2H, dd), 7.30 - 7.39 (2H, m). The NH proton was broadened to baseline, m/r. (ES+), [M+H]+ = 305.1

£bJ.3-[4_-£(_3_S ₁ 5R)-3 _J 5-Dime_thyJ_p_i_perazin_-l -yQ _: 3,_5_-di_tl_uoro-aniJ_i_no]_-5 _: _(methyJamj_no)-6-(_3_- methyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxamide

BrettPhos Pd G3 (23 mg, 0.030 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 0.26 mmol), (3S,5R)-l-(4- bromo-2,6-difluoro-phenyl)-3, 5-dimethyl-piperazine (94 mg, 0.31 mmol), and cesium carbonate (166 mg, 0.510 mmol) in dioxane (4 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford a yellow solid. This material was suspended in 7 N methanolic ammonia (7.3 mL, 51.1 mmol). The resulting mixture was stirred at 100 °C for 16 hours in a microwave reactor. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column using a 5 pm, 30 mm x 150 mm SunFire C18 Prep Column, using 7-17% MeClNMhO as eluent and 0.1% formic acid as modifier, to afford 3-[4-[(3S,5R)-3,5-dimethylpiperazin-l-yl]-3,5- difluoro-anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]p yridin-7-yl)pyrazine-2- carboxamide (0.013 g, 9.74 %) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 0.97

(6H, d), 2.61 (2H, m), 2.78 - 2.99 (7H, m), 4.02 (3H, s), 7.43 (1H, s), 7.53 (2H, d), 7.79 (1H, s), 8.06 (1H, d), 8.52 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.64 (1H, s); m/z\ (ES+), [M+H]+ = 523.3

Example 110

5-(Methylamino)-3-r4-(3-methyl-3.8-diazabicvclor3.2.11oct an-8-vDanilinol-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

{aj _. Sr^rBromopheny^-S-inethyl-S _^ S-diazabicycloLE^JJpctane

Palladium(II) acetate (79 mg, 0.35 mmol) was added to a mixture of (rac)-BINAP (219 mg, 0.350 mmol), l-bromo-4-iodo-benzene (1.49 g, 5.27 mmol) and 3-methyl-3,8- diazabicyclo[3.2. ljoctane dihydrochloride (700 mg, 3.52 mmol) and potassium tert-butoxide

(1.18 g, 10.6 mmol) in toluene (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford a yellow residue. This material was further purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XBridge Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-H?0 as eluent, and 0.1% ammonium bicarbonate as modifier, to afford 8-(4-bromophenyl)-3-methyl-3,8- diazabicyclo[3.2. ljoctane (0.350 g, 35%) as a yellow solid; lH NMR (300 MHz, DMSO-d6) d 1.86 (4H, dtd), 2.06 (3H, s), 2.23 (2H, dd), 2.44 (2H, dd), 4.20 (2H, t), 6.69 - 6.85 (2H, m),

7.20 - 7.35 (2H, m). m/z: (ES+), [M+2+H]+ = 283.0 {¾.Methyl.5-(methylamino)-3 _: ^4 _: (3-methyl-3 _: 8-diazabicyclp[3.2.1Joctan _: 8-_yl)anilino]-6 _: i_3- m ethyl i mi dazpH _^ ^cjpxri din- 7 _r yi)py razi n e-2 _: carbpxxl ate BrettPhos Pd G3 (23 mg, 0.030 mmol) was added to a suspension of cesium carbonate (250 mg, 0.77 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.26 mmol), and 8-(4-bromophenyl)-3-methyl-3,8- diazabicyclo[3.2.1]octane (144 mg, 0.510 mmol) in 1,4-dioxane (2 mL). The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-3-[4-(3-methyl-3,8-diazabicyclo[3.2.1]octan- 8-yl)anilino]-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.080 g, 61%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.80-1.92 (4H, m), 2.08 (3H, s), 2.24-2.38 (2H, m), 2.40- 2.49 (2H, m), 2.90 (3H, d), 3.82 (3H, s), 4.02 (3H, s), 4.18-4.24 (2H, m), 6.83 (2H, d), 7.61 (2H, d), 7.92 (1H, br q), 8.50 (1H, s), 8.52 (1H, s) 9.03 (1H, s), 10.20 (1H, s). m/z (ES+), [M+H]+ = 514.3 metny h mi dazo [4, 5 -c Jpy n din- / _: y IJpy razme-2 _: car b oxarni de tprmate salt 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-(methylamino)-3-[4-(3- methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)anilino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting suspension was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 5-15 MeCN-H O as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-3-[4-(3- methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)anilino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide formate salt (26 mg, 31%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.79 - 1.93 (4H, m), 2.08 (3H, s), 2.32 (2H, d), 2.44 (2H, d), 2.94 (3H, d), 4.02 (3H, s), 4.19 (2H, s), 6.82 (2H, d), 7.30 (1H, s), 7.60 (2H, d), 7.70 (1H, s), 8.01 (1H, br q), 8.16 (1H, s), 8.52 (1H, s), 8.74 (1H, s), 9.01 (1H, s), 11.22 (1H, s). m/z: (ES+), [M+H]+ = 499.3

Example 111

iaJi LS ₁ 4S)-2 _r (4 _: Bromop.heny!)-5-tTiethyl _r 2,5-diazabicycloL2.2,L]heptane (lS,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane (198 mg, 1.77 mmol) was added to 1- bromo-4-iodo-benzene (500 mg, 1.77 mmol), (rac)-BINAP (165 mg, 0.27 mmol), palladium(II) acetate (59.5 mg, 0.27 mmol), and potassium tert-butoxide (595 mg, 5.30 mmol) in toluene (10 mL) at it under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford (lS,4S)-2-(4-bromophenyl)- 5-methyl-2,5-diazabicyclo[2.2.1]heptane (0.150 g, 32%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.98 - 2.05 (1H, m), 2.14 - 2.24 (1H, m), 2.66 (3H, br s), 2.66 - 2.81 (1H, m), 2.95 - 3.10 (2H, m), 3.23 - 3.28 (1H, m), 3.44 - 3.56 (1H, m), 3.95 - 4.20 (1H, m), 6.57 - 6.63 (2H, m), 7.30 - 7.35 (2H, m); m/z: (ES+), [M+2+H]+ = 269.0 {bi _. Methyl _. S^methylammo^-S^^^lS^SJ-S-methyl-^ _^ S-diazabicyclof^.^.lJheptan:^- yI]ani!inpj ₇ 6-(3-methylimidazo[4 _J 5-c]pyridin _: 7-yl)pyrazine-2-carboxylate (lS,4S)-2-(4-Bromophenyl)-5-methyl-2,5-diazabicyclo[2.2.1]he ptane (85 mg, 0.32 mmol) was added to methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), Cesium carbonate (312 mg, 0.96 mmol) and BrettPhos Pd G3 (43.4 mg, 0.05 mmol) in 1,4-dioxane (10 mL) at rt under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-3-[4-[(lS,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl]anilino]-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-2- carboxylate (0.060 g, 38%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.71 - 1.79 (1H, m), 1.82 - 1.89 (1H, m), 2.25 (3H, s), 2.73 - 2.80 (1H, m), 2.89 (3H, d), 3.11 - 3.15 (1H, m), 3.34 - 3.45 (1H, m), 3.82 (3H, s), 4.01 (3H, s), 4.21 - 4.31 (1H, m), 6.59 (2H, d), 7.58

(2H, d), 7.91 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.03 (1H, s), 10.17 (1H, s); two of the bicycle protons were obscured by either residual water or the DMSO solvent peak; m/z\

(ES+). [M+H]+ = 500.2 icJ _. 5 ₇ iMethylaiTiinp)-3 _r £4 _r [( l S,4S)-5 _: methyl _: 2,5-diazabicyclo[2.2. !]heptanr2-ylJanilinol-6- i3-methylimid^o[4 _^ 5-c]pyridin-7 _.r yljpyrazine-2-carbpxamide 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 5-(methylamino)-3-[4-

[(lS,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]anil ino]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (50.0 mg, 0.10 mmol). The resulting suspension was stirred at 85 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm, XB ridge Prep Cl 8 OBD column, 15-30% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-3-[4-[(lS,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl]anilino]-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-2- carboxamide (3.0 mg, 6.2%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.76 (1H, d), 1.85 (1H, d), 2.25 (3H, s), 2.76 (1H, d), 2.93 (3H, d), 3.13 (1H, d), 3.29 - 3.31 (2H, m), 3.40 (1H, m), 4.02 (3H, s), 4.26 (1H, s), 6.59 (2H, d), 7.28 (1H, s), 7.59 (2H, d), 7.69 (1H, s), 8.01 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.18 (1H, s); m/z\ (ES+), [M+H]+ = 484

Example 112 3-r4-r(3S.5R)-3.5-Dimethylpiperazin-l-yl1-3.5-dimethyl-anili no1-5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

_. (aJ _. ijR _j ^Sj- l-dd-Bromo- _. ^^^dimethyl-phenyJJ-j^^dimethyEpiperazine Pd-PEPP SI-IP ent (128 mg, 0.160 mmol) was added to a mixture of 5-bromo-2-iodo-l,3- dimethyl-benzene (500 mg, 1.61 mmol), (2S,6R)-2,6-dimethylpiperazine (220 mg, 1.93 mmol), and cesium carbonate (1.57 g, 4.82 mmol) in DME (20 mL). The resulting mixture was stirred at 90 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 0-60% MeCINMEO as eluent, and 0.1% formic acid as modifier, to (3R,5S)-l-(4-bromo-2,6-dimethyl-phenyl)-3, 5-dimethyl- piperazine (0.200 g, 31%) as a yellow oil which solidified on standing; 1H NMR (300 MHz, DMSO-d6) d 0.98 - 1.08 (6H, m), 2.22 (6H, d), 2.73 - 2.82 (2H, m), 2.82 - 2.96 (2H, m),

3.01 - 3.16 (2H, m), 7.13 (1H, s), 7.21 (1H, s); the NH signal was buried under either DMSO or water residual peak; m/z (ES+), [M+2+HJ+ = 299.0

(bJ.Methyj j-ffl-tfjS _^ SRJ-j^-dimethyJpiperazin-l^yJJo _^ S-dirnethyJ-aniLi.noJ-S- {rnethylaminpJ-6-(3-methylimidazo[4, _. 5-cJpyridin-7-yl)pyrazine: _. 2-carboxylate Brettphos Pd G3 (61 mg, 0.070 mmol) was added to a suspension of cN-l-(4-bromo-2,6- dimethylphenyl)-3,5-dimethylpiperazine (100 mg, 0.34 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (105 mg, 0.34 mmol), and cesium carbonate (329 mg, 1.01 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The crude product was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4-[(3S,5R)-3,5-dimethylpiperazin-l-yl]-3,5-dimethyl-anili no]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (75 mg, 42% yield) as a brown solid. This material was used directly in the next step without further purification. m/z\ (ES+), [M+H]+ = 530.3

{c)7.:I4:£(3S _J 5R) _: 3,5-Dimethylpiper^in _: l-yl]-3 ₁ 5-dimethyl-anilinp]. _: 5-(methylamino)-6 _: (_3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide formate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[4-[(3S,5R)-3,5- dimethylpiperazin-l-yl]-3,5-dimethyl-anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (70 mg, 0.13 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 5-25% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 3-[4- [(3S,5R)-3,5-dimethylpiperazin-l-yl]-3,5-dimethyl-anilino]-5 -(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt (3.0 mg, 4.4%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.04 (6H, d), 2.28 (6H, d), 2.76 - 2.92 (4H, m), 2.98 (3H, d), 3.01 - 3.12 (2H, m), 4.02 (3H, s), 7.38 (1H, s), 7.44 (1H, d), 7.51 (1H, d), 7.76 (1H, s), 8.02 (1H, br q), 8.26 (1H, s), 8.53 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.37 (1H, s); the cyclic NH peak was buried under the DMSO or water peak; m/z\ (ES+), [M+H]+ = 515.3 Example 113

3-r4-r2-(Dimethylamino)ethyl-methyl-amino1anilino1-5-(met hylamino)-6-(3- methylimidazor4.5-c1pyridin-7-yl )pyrazine-2-carboxamide bis-formate salt (aJ _. N/ _.T id-BromophenylJ-N _^ N _^ N'-trimethyl-etMne-l^-diamine

Palladium(II) acetate (0.079 g, 0.35 mmol) was added to l-bromo-4-iodo-benzene (1.00 g, 3.53 mmol), N,N',N'-trimethylethane- 1,2-diamine (0.722 g, 7.07 mmol), potassium tert- butoxide (1.19 g, 10.6 mmol), and (rac)-BINAP (0.22 g, 0.35 mmol) in toluene (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% EtOH-DCM as eluent, to afford N'-(4-bromophenyl)-N,N,N' -trimethyl-ethane- 1,2-diamine (0.600 g, 66%) as a brown oil; 1HNMR (300 MHz, DMSO-d6) d 2.16 (6H, s), 2.34 (2H, t), 2.86 (3H, s), 3.38 (2H, t), 6.49 - 6.71 (2H, m), 7.20 - 7.44 (2H, m); m/r. (ES+), [M+H]+ = 257.0

{¾ _. Methyl _. 3-[4-[2-(dimethylamino)ethyl _: methyl _: amino]anilinpJ:5-(methylaming)-6-(3 _: methyhmidazg£4 ₁ 5 _: c]pyridin-7 _: ylJpyrazine-2 _: carboxylate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of N'-(4-bromophenyl)- N,N,N' -trimethyl-ethane- 1,2-diamine (164 mg, 0.640 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% EtOH-DCM as eluent, to afford methyl 3-[4-[2-(dimethylamino)ethyl-methyl-amino]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (0.080 g, 51%) as a brown oil. 1H NMR (400 MHz, DMSO-d6) 52.18 (6H, s), 2.34 - 2.42 (2H, m), 2.86 - 2.93 (6H, m), 3.37 - 3.44 (2H, m), 3.81 (3H, s), 4.01 (3H, s), 6.71 (2H, d), 7.59 (2H, d), 7.84 - 7.96 (1H, m), 8.49 (1H, s), 8.53 (1H, s), 9.02 (1H, s), 10.17 (1H, s); m/z (ES+), [M+H]+ 490.2

(c) 3-[4-[2-(Dimethylamino)ethyl-methyl-amino]anilino]-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-[4-[2-

(dimethylamino)ethyl-methyl-amino]anilino]-5-(methylamino )-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (30 mg, 0.06 mmol). The suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 6-16% MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[2-(dimethylamino)ethyl-methyl-amino]anilino]-5-(methyl amino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide bis-formate salt (3.0 mg, 8.5%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.19 (6H, s), 2.39 (2H, t), 2.88 (3H, s),

2.92 (3H, d), 3.39 (2H, t), 4.01 (3H, s), 6.68 - 6.74 (2H, m), 7.27 (1H, s), 7.59 (2H, d), 7.68 (1H, s), 8.00 (1H, br q), 8.22 (2H, s), 8.51 (1H, s), 8.73 (1H, s), 9.00 (1H, s), 11.18 (1H, s); m/z: (ES+), [M+H]+ = 475.2

Example 114

3-r4-r3-(Dimethylamino)azetidin-l-yllanilinol-5-(methylam ino)-6-(3-methylimidazor4,5- c1pyridin-7-vDpyrazine-2-carboxamide bis-formate salt

{a) _. l:0 _. :B mophenyl)-N N _: dimethyl-azetidin _: 3_-amine

Palladium(II) acetate (0.079 g, 0.35 mmol) was added slowly to a mixture of l-bromo-4-iodo- benzene (1.00 g, 3.54 mmol), N,N-dimethylazetidin-3-amine (0.709 g, 7.08 mmol), (rac)- BINAP (0.220 g, 0.35 mmol), and potassium tert-butoxide (1.19 g, 10.6 mmol) in toluene (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0- 10% MeOH-DCM as eluent, to afford l-(4-bromophenyl)-N,N-dimethyl-azetidin-3-amine (0.670 g, 74%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 2.10 (6H, s), 3.18 (1H, td), 3.52 (2H, dd), 3.88 (2H, t), 6.32 - 6.43 (2H, m), 7.23 - 7.37 (2H, m); m/z: (ES+), [M+H]+ = 255.0

{¾ _. Methyl _. 3-[4-[3-(dimethylamino) _. ^etidin _: l _: yl]anilinpJ-5-(methylarnino) _. :6-(3- methyHmdazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

BrettPhos Pd G3 (14 mg, 0.020 mmol) was added to a suspension of l-(4-bromophenyl)-N,N- dimethyl-azetidin-3-amine (41 mg, 0.16 mmol), methyl 3 -amino-5 -(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), and cesium carbonate (156 mg, 0.480 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4-[3-(dimethylamino)azetidin-l-yl]anilino]-5-(methylamino )-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.030 g, 39%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) d 2.12 (6H, s), 2.88 (3H, d), 3.50 - 3.57 (1H, m), 3.82 (3H, s), 3.88 - 3.95 (2H, m), 4.01 (3H, s), 4.33 - 4.39 (2H, m), 6.47 (2H, d), 7.60 (2H, d), 7.91 (1H, br q), 8.49 (1H, s), 8.54 (1H, s), 9.03 (1H, s), 10.18 (1H, s); m/z : (ES+), [M+H]+ = 488.2 _. (c) _. 3rI4 _: [3 _T (Dimethy]amino)azetidin-l _T ylJanilinp} _T 5-(methyJamino)-6 _: (3-methyJirnidazoL4,5- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide bis-fprmate.salt 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-[4-[3- (dimethylamino)azeti din- l-yl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (40 mg, 0.08 mmol) The resulting suspension was stirred at 80 °C for 25 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Shield RP18 OBD column, 5-16% MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[3- (dimethylamino)azeti din- l-yl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide bis-formate salt (13 mg, 29%) as a brown solid; 1HNMR (400 MHz, DMSO-d6) d 2.10 (6H, s), 2.92 (3H, d), 3.50 (2H, dd), 3.89 (2H, t), 4.01 (3H, s), 6.46 (2H, d), 7.28 (1H, s), 7.59 (2H, d), 7.69 (1H, s), 7.98 (1H, br q), 8.20 (2H, s), 8.51 (1H, s),

8.72 (1H, s), 9.00 (1H, s), 11.19 (1H, s); m/z : (ES+), [M+H]+ = 473.2

Example 115

3 -G3 -Cvano-4-G (3 S.5R)-3.5-dimethylpiperazin- 1 -yllanilinol-5-(methylamino)-6-(3 - methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

£a)..lerEBy.ly!.i.?E _J 6Sj.-4:(4-brpmp _: 2_-cya_np-ph_eny])_ _: _2,6_-dim_et_hyJ_-pip_erazi_ne-l_ _: _carbpxyJate Palladium (II) acetate (73 mg, 0.32 mmol) was added to a mixture of 5-bromo-2- iodobenzonitrile (500 mg, 1.62 mmol), tert-butyl (2S,6R)-2,6-dimethylpiperazine-l- carboxylate (348 mg, 1.62 mmol), (rac)-BINAP (202 mg, 0.320 mmol), and cesium acetate (1.59 g, 4.87 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petroleum ether as eluent, to afford tert- butyl (2R,6S)-4-(4-bromo-2-cyano-phenyl)-2,6-dimethyl-piperazine-l -carboxylate (0.510 g, 80 %) as a yellow solid. 1H NMR (Chloroform-d, 400 MHz) d 1.46 - 1.49 (6H, m), 1.51 (9H, s), 2.88 - 2.98 (2H, m), 3.29 - 3.38 (2H, m), 4.24 - 4.37 (2H, m), 6.94 (1H, d), 7.62 (1H, dd),

7.72 (1H, d); m/z: (ES+), [M+H]+ = 394

_. (bJ _. Methy! _.. 3 _. -[4rI(3S ₁ 5R)-4-tert-butpxycarbonyl _r 3,5-dimHhy'l _: piperazin _T j -y'l]-3-cyano- anilinpJ-5 _: (methylaminp) _: 6_-X3-methylimidazpl4 _I 5-c] _i pjridin _: 7 _r y_l)pyrazine-2-carboxylate BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxylate (100 mg, 0.32 mmol), tert-butyl (2R, 6S)-4-(4-bromo-2-cyano-phenyl)-2, 6-dimethyl-piperazine- 1- carboxylate (138 mg, 0.350 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4- dioxane (1 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 15 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford methyl 3-[4-[(3S,5R)-4-tert- butoxy carbonyl-3, 5-dimethyl-piperazin-l-yl]-3-cyano-anilino]-5-(methylamino)- 6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.137 g, 69%) as a white solid. 1H NMR (400 MHz, DMSO-d6) d 1.34 - 1.38 (6H, m), 1.43 (9H, s), 2.84 - 2.94 (5H, m), 3.17 - 3.23 (2H, m), 3.83 (3H, s), 4.01 (3H, s), 4.10 - 4.19 (2H, m), 7.24 (1H, d), 7.90 (1H, dd), 8.01

(1H, br q), 8.43 (1H, d), 8.49 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.41 (1H, s); m/z : (ES+), [M+H]+ = 627.5 {9)M9.F^.^.:I3 _: rgahr-4 _: [(38 _; 5K)-3 _: 5-άί^6ΐ1ig1rίr6Gazίh _: 1-^1]ahί1ίho]-5 _: (ih6ΐ1ig1aihίho3-6-(3- JI ¹ ethyli mjdazo^ _^ S _: _c]pyri din- 7 _: yjjpy raz_ine_-2 _: carb oxyjate

4 N HC1 in in 1,4-dioxane (3.0 mL, 12 mmol) was added to a solution of methyl 3-[4- [(3 S,5R)-4-tert-butoxy carbonyl -3, 5-dimethyl-piperazin-l-yl]-3-cyano-anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (125 mg, 0.200 mmol) in DCM (5 mL). The resulting mixture was stirred at room temperature for 2 hours.

The reaction was then concentrated. The resulting residue was triturated in saturated aqueous sodium bicarbonate, filtered, and dried under vacuum to afford methyl 3-[3-cyano-4-[(3S,5R)- 3,5-dimethylpiperazin-l-yl]anilino]-5-(methylamino)-6-(3-met hylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.097 g, 92%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.31 (6H, d), 2.87 (3H, d), 2.92 - 3.00 (2H, m), 3.32 - 3.49 (4H, m), 3.82 (3H, s), 4.13 (3H, s), 7.29 (1H, d), 7.62 (1H, br q), 7.93 (1H, dd), 8.37 - 8.42 (1H, m), 8.71 (1H, s), 9.02 (1H, s), 9.64 (1H, s), 10.44 (1H, s). m/z\ (ES+), [M+H]+ = 527.3

.(d).3 -[3 -Cy ano-4 _: £(3 5R)_ _: 3 , 5-dimethy Jpiperazin- 1 -yl ] anilino] - 5 _: {methy 1 amino)-6-(3 - methyhmMazo[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[3-cyano-4-[(3S,5R)-3,5- dimethylpiperazin-l-yl]anilino]-5-(methylamino)-6-(3-methyli midazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (88 mg, 0.17 mmol). The resulting mixture was stirred at 80 °C for 30 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm, Xselect CSH OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[3-cyano-4-[(3S,5R)-3,5-dimethylpiperazin-l-yl]anilino]-5- (methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (30 mg, 35%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.01 (6H, d), 2.26 - 2.36 (2H, m), 2.89 - 2.99 (5H, m),

3.25 - 3.32 (2H, m), 4.01 (3H, s), 7.14 (1H, d), 7.42 (1H, s), 7.70 - 7.83 (2H, m), 8.11 (1H, br q), 8.39 (1H, d), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.52 (1H, s); m/r. (ES+), [M+H]+ = 512.3

Example 116

3-r2.3-Difluoro-4-r4-(4-methylpiperazin-l-vn-l-piperidyll anilinol-5-(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

iaJ LrIL:i2 _. J _. :DifluQro-4rnitro-phenyl)-4 ₇ pjperidyl] _T 4-methy!-piperazine Potassium carbonate (1.382 g, 10.00 mmol) was added to a solution of l,2,3-trifluoro-4-nitro- benzene (1.771 g, 10.00 mmol) and l-methyl-4-(4-piperidyl)piperazine (1.833 g, 10.00 mmol) in DMSO (50 mL) at 0 °C. The resulting mixture was stirred at room temperature for 2 h. The reaction was then diluted with water (300 mL) and extracted three times with EtOAc (150 mL each). The combined organic layers were washed five times with water (200 mL each), dried over sodium sulfate, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, to afford l-[l-(2,3-difluoro-4-nitro- phenyl)-4-piperidyl]-4-methyl-piperazine (0.728 g, 21% yield) as a yellow solid. 1H NMR (500MHz, DMSO-d6) d 1.48 (2H, qd), 1.83 (2H, d), 2.11 (3H, s), 2.17 - 2.35 (4H, m), 2.36 - 2.48 (5H, m), 2.96 (2H, t), 3.76 (2H, d), 6.94 (1H, t), 7.87 (1H, t). 19F NMR (470 MHz, DMSO-d6) d -142.01, -147.27. m/z\ (ES+), [M+H]+ = 341.8 .(bJ _. 2,3-Ditluoro-4-[4-(4-methylpiperazin _T l-yl)-l _T pipendy!laniline A mixture of l-[l-(2,3-difluoro-4-nitro-phenyl)-4-piperidyl]-4-methyl-pip erazine (728 mg, 2.14 mmol) and 10 wt% palladium on carbon (228 mg, 0.210 mmol) was stirred in MeOH (10.7 mL) under a hydrogen atmosphere at room temperature for 3 hours. The reaction was then diluted with MeOH (50 mL), filtered through Celite, and concentrated to afford 2,3- difluoro-4-[4-(4-methylpiperazin-l-yl)-l-piperidyl]aniline as a brown film (0.664 g, quantitative). 1H NMR (500MHz, DMSO-d6) 1.51 (2H, qd), 1.73 - 1.86 (2H, m), 2.14 (3H, s), 2.17 - 2.41 (6H, m), 2.51 - 2.58 (4H, m), 3.10 - 3.20 (3H, m), 4.99 (2H, s), 6.45 (1H, td), 6.59 (1H, td). m/r. (ES-), [M-H]- = 309.4

{cjNrLS^^Difluprp-flrX^^^methylpiperazin-J^y^^l^piperidyl JphenylJfqrrnamide Formic acid (1.81 mL, 44.9 mmol) and acetic anhydride (4.44 mL, 47.1 mmol) were combined and stirred at 60 °C for 15 minutes. The resulting mixture was added dropwise to a solution of 2,3-difluoro-4-[4-(4-methylpiperazin-l-yl)-l-piperidyl]anili ne (664 mg, 2.14 mmol) in THF (8 mL). The resulting mixture was stirred at room temperature for 16 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 15% MeOH-DCM as eluent, to afford N-[2,3-difluoro-4-[4-(4- methylpiperazin-l-yl)-l-piperidyl]phenyl]formamide (0.550 g, 76% yield) as an off-white solid. 1H NMR (400MHz, DMSO-d6) d 1.54 (2H, qd), 1.73 - 1.88 (2H, m), 2.16 (3H, s), 2.22

- 2.42 (5H, m), 2.51 - 2.57 (2H, m), 2.66 (2H, br t), 3.08 - 3.57 (4H, m), 6.81 (1H, td), 7.61 (1H, td), 8.25 (1H, d), 10.05 (1H, s). m/z\ (ES+), [M+H]+ = 339.9

{dJ _. Methyl _. 6-cMpro-3 :[2 _^ 3 -diflugro-4 _: X4-(4 _: methylpiperazin- 1 _: yl) _: 1 -piperidylJanilino]-5- {rnethylaminoJpyrazine-2 _: carbgxylate

60 wt% Sodium hydride in mineral oil (71.5 mg, 1.79 mmol) was added to a solution of N- [2,3-difluoro-4-[4-(4-methylpiperazin-l-yl)-l-piperidyl]phen yl]formamide (550 mg, 1.63 mmol) in DMF (8 mL). The resulting mixture was stirred at room temperature for 15 minutes. Methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2-carboxylate (357 mg, 1.63 mmol) to the flask. The resulting mixture was stirred at 60 °C for 16 h. Potassium carbonate (1.00 g, 7.24 mmol) and MeOH (3 mL) were added. The resulting mixture was stirred at 60 °C for 1 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 15% MeOH-DCM as eluent, to afford methyl 6-chloro-3-((2,3- difluoro-4-(4-(4-methylpiperazin- 1 -yl)piperidin- 1 -yl)phenyl)amino)-5 - (methylamino)pyrazine-2-carboxylate (0.366 g, 44% yield) as a beige solid. 1H NMR (400MHz, DMSO-d6) d 1.54 (2H, qd), 1.83 (2H, br d), 2.13 (3H, s), 2.20 - 2.40 (5H, m), 2.61

- 2.72 (2H, m), 2.89 (3H, d), 3.36 (2H, br d), 3.81 (3H, s), 6.85 (1H, td), 7.95 (1H, q), 8.01 (1H, td), 10.27 (1H, d). 4 protons were buried under the DMSO signal. m/z\ (ES+), [M+H]+ = 509.9

£9)..6:.CLb]oro _: _3_-[2 _J _3_-diflupro-4 _: L4-(_4-methy]pj_p_erazi_n _: _l_-y_l)_-l_ _: p_iperidyJ2aniJ_i_n_o2 _: _5_-

{rnethylaminpjpyrazme-2 _: carbpxamide

7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 6-chloro-3-[2,3-difluoro- 4-[4-(4-methylpiperazin-l-yl)-l-piperidyl]anilino]-5-(methyl amino)pyrazine-2-carboxylate (366 mg, 0.720 mmol). The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford 6-chloro-3-[2,3- difluoro-4-[4-(4-methylpiperazin-l-yl)-l-piperidyl]anilino]- 5-(methylamino)pyrazine-2- carboxamide (0.255 g, 72% yield) as a yellow solid. 1H NMR (400MHz, DMSO-d6) d 1.54 (2H, qd), 1.83 (2H, br d), 2.18 - 2.40 (5H, m), 2.65 (2H, br t), 2.91 (3H, d), 3.34 (2H, br d), 6.83 (1H, dt), 7.39 (1H, br s), 7.61 (1H, br s), 7.666 (1H, br q), 8.12 (1H, dt), 11.47 (1H, d). 4 protons were buried under the DMSO signal. m/z\ (ES+), [M+H]+ = 495.3

-[2 _^ 3 -Dill uoro-4-[4-0-ixiephylpiperarin _: l-yl)-l _: piperidyl}anilinp}-5-(iTiethyJatTiino) _. -6: _. (3- methy _. hmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide 6-Chloro-3-[2,3-difluoro-4-[4-(4-methylpiperazin-l-yl)-l-pip eridyl]anilino]-5- (methylamino)pyrazine-2-carboxamide (255 mg, 0.520 mmol), 2-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (158 mg, 0.640 mmol), XPhos Pd G3 (44 mg, 0.050 mmol), XPhos (25 mg, 0.050 mmol), and potassium phosphate (328 mg, 1.55 mmol) were combined. The reaction vessel was evacuated and backfilled with nitrogen. Dioxane (7.2 mL) and water (0.72 mL) were added. The resulting mixture was stirred at 60 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography on KP-Sil, using 0-20% MeOH-DCM as eluent and 1% ammonium hydroxide as modifier, afford 3-[2,3-difluoro-4-[4-(4-methylpiperazin-l-yl)-l- piperidyl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c] pyridin-7-yl)pyrazine-2- carboxamide (0.191 g, 63% yield) as a yellow solid. 1HNMR (500MHz, DMSO-d6) d 1.58 (2H, qd), 1.85 (2H, br d), 2.20 (3H, s), 2.25 - 2.45 (5H, m), 2.50 - 2.62 (4H, m), 2.68 (2H, br t), 2.93 (3H, d), 3.37 (2H, br d), 4.02 (3H, s), 6.87 (1H, td), 7.40 (1H, br s), 7.77 (1H, br s), 8.04 (1H, br q), 8.33 (1H, td), 8.52 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.61 (1H, d). m/z\ (ES+), [M+H]+ = 592.1

Example 117

3-rr6-(4-Isopropylpiperazin-l-vn-5-methyl-3-pyridyllamino l-5-(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

{4).l:i5:Brorno _: 3_-methyl_-2 _: pyridyl)-4 _: ispprppyl.-piperazine

DIPEA (4.60 mL, 26.3 mmol) was added slowly to a solution of 5-bromo-2-fluoro-3-methyl- pyridine (1.00 g, 5.26 mmol) and 1-isopropylpiperazine (0.675 g, 5.26 mmol) in DMSO (15 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction mixture was then diluted with DCM (100 mL) and washed three times with water (100 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford l-(5- bromo-3-methyl-2-pyridyl)-4-isopropyl-piperazine (0.480 g, 31%) as a beige waxy solid; 1H NMR (300 MHz, DMSO-d6) d 0.96 — 1.11 (6H, m), 2.22 (3H, s), 2.47 - 2.62 (4H, m), 2.68 (1H, heptet), 3.00 - 3.09 (4H, m), 7.71 (1H, d), 8.17 (1H, d); m/r. (ES+), [M+2+H]+ = 300.0 {¾ _. Methyl _. 3_-[L6-(4rispprppylpiperazm _: d^yl)-5-methyl-3-p _j ridy)Jamino]-5-(methylaminp)-6_- i3-methylimid^o[4 _^ 5-c]pyridin-7 _.r yljpyrazine-2-carbpxylate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of l-(5-bromo-3-methyl-2- pyridyl)-4-isopropyl-piperazine (95 mg, 0.32 mmol), methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), and cesium carbonate (0.313 g, 0.960 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 15 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[[6-(4-isopropylpiperazin-l-yl)-5-methyl-3-pyridyl]amino]- 5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.100 g, 59%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.02 (6H, d), 2.26 (3H, s), 2.55 - 2.63 (4H, m), 2.65 - 2.76 (1H, m), 2.90 (3H, d), 2.97 - 3.08 (4H, m), 3.83 (3H, s), 4.01 (3H, s), 7.94 (1H, br q), 8.05 (1H, d), 8.46 - 8.55 (3H, m), 9.04 (1H, s), 10.23 (1H, s). m/z\ (ES+), [M+H]+ = 531.4 _. (c) _. 3rI[6rf4-IsopropyJpiperazin- l-yl)-5 _r methyl _: 3-pyridyJ]amino] _r 5-(methylaminp)-6-(3 ₇ rnethyhmidazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide 7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 3-[[6-(4- isopropylpiperazin-l-yl)-5-methyl-3-pyridyl]amino]-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (50 mg, 0.09 mmol). The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm XBridge Prep OBD Cl 8 column, 20-50% MeCN-10 mM aqueous ammonium bicarbonate as eluent, and 0.1% ammonium hydroxide as modifier, to afford 3-[[6-(4-isopropylpiperazin-l-yl)-5-methyl- 3-pyridyl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]py ridin-7-yl)pyrazine-2- carboxamide (10 mg, 20%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.02 (6H, d), 2.26 (3H, s), 2.59 (4H, t), 2.66 - 2.74 (1H, m), 2.94 (3H, d), 2.97 - 3.04 (4H, m), 4.01 (3H, s), 7.37 (1H, s), 7.74 (1H, s), 8.02 (2H, d), 8.52 (2H, s), 8.72 (1H, s), 9.02 (1H, s), 11.33 (1H, s); m/r. (ES+), [M+H]+ = 516.2

Example 118

3-rr5-Methoxy-6-(4-methylpiperazin-l-vn-3-pyridyl1amino1- 5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-yl )pyrazine-2-carboxamide

.(a).. I :.( 5 : B rom o _: 3 -m eth ox y-2 -pyridy 1_ ) -4 -methyl rp.i.p erazin e

Potassium tert-butoxide (1.07 g, 9.56 mmol) and 1-methylpiperazine (0.319 g, 3.19 mmol) were sequentially added to a mixture of 5-bromo-2-iodo-3-methoxy-pyridine (1.00 g, 3.19 mmol), rac-BINAP (0.397 g, 0.640 mmol), and palladium(II) acetate (0.143 g, 0.640 mmol) in toluene (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford l-(5-bromo-3-methoxy-2- pyridyl)-4-methyl-piperazine (0.500 g, 55%) as a yellow solid; 1H NMR (400 MHz, DMSO- d6) d 2.19 (3H, s), 2.37 - 2.43 (4H, m), 3.24 - 3.31 (4H, m), 3.82 (3H, s), 7.41 (1H, d), 7.85 (1H, d); m/z: (ES+), [M+2+H]+ = 288.1

{bJ _. Methyl _. 3-[L5-methoxy-6-(4 _: methylpiperazin-l _: yl) _: 3-pyridyl]amino]:5-(methylaming)-6-

_. (3 _.T rnethyJirn!dazoL4,5 _T c]pyridin-7:yJJpyrazine-2-carbgxylate l-(5-Bromo-3-methoxy-2-pyridyl)-4-methyl-piperazine (137 mg, 0.48 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (150 mg, 0.48 mmol), cesium carbonate (468 mg, 1.44 mmol), and BrettPhos Pd 3G (65 mg, 0.070 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[[5-methoxy-6-(4-methylpiperazin-l-yl)-3-pyridyl]amino]-5- (methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.060 g, 24%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.64 - 2.82 (4H, m), 2.92 (3H, d), 3.04 - 3.18 (7H, (1H, s), 8.52 (1H, s), 9.05 (1H, s), 10.37 (1H, s); m/z: (ES+), [M+H]+ = 519.0 .(cJ _. 3rI[5-Methoxy _T 6-(4-methylpiperazin-j _r yl)-3-pyridyl]amino]-5-(triethylarriinp) _T 6-(3- methyHmMazp[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carbpxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[[5-methoxy-6-(4- methylpiperazin-l-yl)-3-pyridyl]amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin- 7-yl)py ^raz ine-2-carboxylate (50 mg, 0.10 mmol). The resulting suspension was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm XBridge Prep OBD C18 column, 11-41% MeCN-ThO as eluent, and 0.1% NH4HCO3 as modifier to afford 3-[[5-methoxy-6-(4- methylpiperazin-l-yl)-3-pyridyl]amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin- 7-yl)py ^raz i ⁿ e-2-carboxamide (13 mg, 27%) as a yellow solid; 1H NMR (400 MHz, DMSO- d6) d 2.21 - 2.42 (4H, m), 2.96 (3H, d), 3.25 (4H, m), 3.86 (3H, s), 4.01 (3H, s), 7.37 (1H, br s), 7.75 (1H, br s), 7.96 (1H, s), 7.98 (1H, br q), 8.09 (1H, d), 8.52 (1H, s), 8.71 (1H, s), 9.02 (1H, s), 11.42 (1H, s). The piperazine NMe protons were buried under solvent; m/z: (ES+),

[M+H]+ = 504.2

Example 119

5-(Methylarnino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3- IT5-methyl-6-r(TR.4R)-5-methyl- 2.5-diazabicvclor2.2.11heptan-2-yll-3-pyridyllaminolpyrazine -2-carboxamide

{aXtert-Buty!X1^4R) _: 5 _r X5 _: bromp-3-metibyl-2-pyridyr)-2 _Jt 5-diazabicyclo[2..2..1]heptMie-2- carbpxylate

5-Bromo-2-fluoro-3-methyl-pyridine (1.00 g, 5.26 mmol) was added to a solution of tert-butyl (lR,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (1.04 g, 5.26 mmol) and DIPEA (2.76 mL, 15.8 mmol) in DMSO (1 mL). The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 x 100 mm XB ridge Prep C18 OBD column, decreasingly polar mixtures ofMeCN-HiO, and 0.5% ammonium bicarbonate as modifier, to afford tert-butyl (lR,4R)-5- (5-bromo-3-methyl-2-pyridyl)-2,5-diazabicyclo[2.2.1]heptane- 2-carboxylate (0.400 g, 21%) as a yellow oil; 1H NMR (300 MHz, DMSO-d6) d 1.37 (9H, d), 1.78-1.88 (2H, m), 2.20 (3H, s), 3.19-3.29 (1H, m), 3.30-3.33 (1H, m), 3.43-3.49 (1H, m), 3.69-3.78 (1H, m), 4.34-4.44 (1H, m), 4.60 (1H, s), 7.56-7.60 (1H, m), 8.01-8.04 (1H, m); m/z: (ES+), [M+H]+ = 368.1 {¾4ert:ButyL(lR _^ 4¾-5-[5-[L3-methQxycarbonyl-6-(methylaminp) _. :5-(3-methylimidazoX4,5 _: c]pyridin-7 _: ylJpyrazin-2 _: ylJaminpJ:3_-methyl-2 _: pyridyl] _.: 2,5-diazabicyclo[2 _; 2 _; l}heptane-2- carbpxylate tert-Butyl (lR,4R)-5-(5-bromo-3-methyl-2-pyridyl)-2,5-diazabicyclo[2.2. 1]heptane-2- carboxylate (250 mg, 0.68 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (170 mg, 0.54 mmol), cesium carbonate (664 mg, 2.04 mmol), and BrettPhos Pd G3 (62 mg, 0.070 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford tert-butyl (lR,4R)-5-[5-[[3- methoxycarbonyl-6-(methylamino)-5-(3-methylimidazo[4,5-c]pyr idin-7-yl)pyrazin-2- yl]amino]-3-methyl-2-pyridyl]-2,5-diazabicyclo[2.2.1]heptane -2-carboxylate (0.250 g, 61% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.38 (9H, d), 1.75 - 1.92 (2H, m), 2.24 (3H, s), 2.88 (3H, d), 3.19 - 3.30 (1H, m), 3.32 - 3.41 (1H, m), 3.55 (1H, d), 3.67 - 3.76 (1H, m), 3.83 (3H, s), 4.02 (3H, s), 4.40 (1H, d), 4.59 (1H, s), 7.87 - 7.99 (2H, m), 8.38 (1H, s), 8.50 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.12 (1H, s). m/z: (ES+), [M+H]+ = 601.3. {9X5 _:i (Methyl^jnp)-6 _:( (3 _: methyHmid^p£4 ₁ 5 _: c]pyridin-7 _r yJQ-3-[[5 _: methyl:6-[( _i lR _J 4R)-5- methy_l _: 2 _J 5-diazabicyclp[2_.2._lJheptan-2-yl] _.: 3 _: pyridylJaminp}pyrazine-2-carbgxamide formate salt tert-Butyl (lR,4R)-5-[5-[[3-methoxycarbonyl-6-(methylamino)-5-(3-methyl imidazo[4,5- c]pyridin-7-yl)pyrazin-2-yl]amino]-3-methyl-2-pyridyl]-2,5-d iazabicyclo[2.2.1]heptane-2- carboxylate (200 mg, 0.33 mmol) was added to a solution of TFA (1.00 mL, 13.0 mmol) in DCM (10 mL). The resulting mixture was stirred at 25 C for 3 hours. The reaction was then concentrated. The resulting residue was dissolved in MeOH (10 mL). 37 wt% aqueous formaldehyde (0.028 mL, 1.00 mmol) and sodium triacetoxyborohydride (353 mg, 1.66 mmol) were added. The resulting mixture was stirred at 25 C for 2 hours. The reaction was then concentrated. The residue was suspended in 7 N methanolic ammonia (10 mL, 70 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 19 x 250 mm XSelect CSH Prep C18 OBD column, 10-19% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5 -methyl-6- [(lR,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-pyri dyl]amino]pyrazine-2- carboxamide formate salt (27 mg, 15%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.78 (1H, d), 1.93 (1H, d), 2.24 (3H, s), 2.47 (3H, s), 2.85 - 3.00 (4H, m), 3.11 (1H, d), 3.43 - 3.52 (2H, m), 3.67 (1H, s), 4.01 (3H, s), 4.46 (1H, s), 7.29 - 7.39 (1H, m), 7.68 - 7.78 (1H, m), 7.90 (1H, d), 8.01 (1H, br q), 8.26 (1H, s), 8.38 (1H, d), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.18 (1H, s); m/z: (ES+), [M+H]+ = 500.2

Example 120

3-rr5-Chloro-6-r(lR.4R)-5-methyl-2.5-diazabicvclor2.2.11h eptan-2-yll-3-pyridyllaminol-5- (methyl ami no )-6-(3-methyli mi dazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

£a)4ert-Buty!.(;iK4R).:5ri5 _: bromoo _: chjprq _: .2-pyridyJJ-2J. _: diazab).cyclo[2,2..1Jheptane-2- carbpxylate tert-Butyl (lR,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (1.04 g, 5.26 mmol) was added to a solution of 5-bromo-2-fluoro-3-methyl-pyridine (1.00 g, 5.26 mmol) and DIPEA (2.76 mL, 15.8 mmol) in DMSO (20 mL). The resulting mixture was stirred at 100 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 100 mm XB ridge Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-H?0 as eluent, and 0.1% ammonium bicarbonate as modifier, to afford tert-butyl (lR,4R)-5-(5-bromo-3-chloro-2-pyridyl)-2,5-diazabicyclo[2.2. l]heptane-2- carboxylate (1.00 g, 49%) as a yellow oil; 1H NMR (300 MHz, DMSO-d6) d 1.37 (9H, d), 1.81 - 1.92 (2H, m), 3.30 - 3.33 (1H, m), 3.38 - 3.49 (2H, m), 3.86 - 3.96 (1H, m), 4.37 - 4.50 (1H, m), 4.70 - 4.82 (1H, m), 7.97 (1H, d), 8.18 (1H, d). m/z: (ES+), [M+H]+ = 388.0 {¾4ert:ButyL(lR _^ 4¾-5-[3-cMorQ-5:[[3-methoxycarbpnyl-6-(methylamino)-5 _: Q- methyHmkdazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazin-2 _: ylJaminoJ: _. 2-gyridyl]-2 _i 5- diazabicyclpJ^2.2.1Jheptane-2 _: carbpxylate tert-Butyl (lR,4R)-5-(5-bromo-3-chloro-2-pyridyl)-2,5-diazabicyclo[2.2. 1]heptane-2- carboxylate (250 mg, 0.64 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (161 mg, 0.510 mmol), cesium carbonate (524 mg, 1.61 mmol), and BrettPhos Pd G3 (47 mg, 0.050 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford tert-butyl (lR,4R)-5-[3- chloro-5-[[3-methoxycarbonyl-6-(methylamino)-5-(3-methylimid azo[4,5-c]pyri din-7- yl)pyrazin-2-yl]amino]-2-pyridyl]-2,5-diazabicyclo[2.2. l]heptane-2-carboxylate (0.200 g, 50%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.38 (9H, d), 1.86 (2H, d), 2.87 (3H, d), 3.33 - 3.43 (2H, m), 3.50 (1H, d), 3.83 (3H, s), 3.85 - 3.95 (1H, m), 4.02 (3H, s),

4.42 (1H, d), 4.74 (1H, d), 8.00 (1H, br q), 8.38 (1H, d), 8.42 (1H, d), 8.50 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 10.16 (1H, s). m/z: (ES+), [M+H]+ = 621.3

(?) Methyl 3 :_[ [5-chl pro-6 ^QPLflR)- 5 -methyl -2, 5 -diazabicyclo[2.2.1 Jheptan _: 2-_yl]_-3 _: py _. ridyl]aminpl-5 _r (methylarninp)-6-(3-rnethylimidazp[4,5-c]pyridinr7-y!) pyiazine:2- carbpxylate tert-Butyl (lR,4R)-5-[3-chloro-5-[[3-methoxycarbonyl-6-(methylamino)-5- (3- methylimidazo[4,5-c]pyridin-7-yl)pyrazin-2-yl]amino]-2-pyrid yl]-2,5- diazabicyclo[2.2. l]heptane-2-carboxylate (10 mg, 0.02 mmol) was added to 4 N HC1 in dioxane (1.0 mL, 4.0 mmol). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was dissolved in MeOH (10 mL). 37 wt% aqueous formaldehyde (116 μL, 1.27 mmol) and sodium triacetoxyborohydride (447 mg, 2.11 mmol) were sequentially added. The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was diluted with DCM (50 mL) and washed three times with saturated aqueous sodium bicarbonate (50 mL each). The organic layer was dried overNaiSCL, filtered, and concentrated to afford methyl 3-[[5-chloro-6-[(lR,4R)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl]-3-pyridyl]amino]-5-(methylam ino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.200 g, 89%); 1H NMR (300 MHz, DMSO-d6) d 1.63 - 1.71 (1H, m), 1.78-1.84 (1H, m), 2.28 (3H, s), 2.73 - 2.78 (3H, m), 2.88 (3H, d), 3.44- 3.54 (1H, m), 3.60-3.70 (1H, m), 3.83 (3H, s), 4.01 (3H, s), 4.57 (1H, s), 8.00 (1H, br q), 8.31-8.35 (1H, m), 8.38-8.42 (1H, m), 8.50 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.14 (1H, s); m/z: (ES+), [M+H]+ = 535.2

{dJ _. 3-[L5-CMoro-6 _: ^(lR,4R)_-5 _: methyl _: 2,5_-diazabicyclo[2_.2_._lJheptan-2-yl]-3 _: pyridyl] _. aming] _. - 5^(iliethylammo)-6 _: 0 _: methyHmidazg[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carboxamide 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[[5-chloro-6-[(lR,4R)-5- methyl-2, 5-diazabicyclo[2.2. l]heptan-2-yl]-3-pyridyl]amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (170 mg, 0.32 mmol). The resulting suspension was stirred at 80 °C for 1 day. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 2-25% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 3- [[5-chloro-6-[(lR,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan -2-yl]-3-pyridyl]amino]-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide (60 mg, 32%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.72-1.80 (1H, m), 1.96-1.98 (1H, m), 2.40 (3H, s), 2.84-2.89 (1H, m), 2.92 (3H, d), 2.94 - 3.00 (1H, m), 3.54-3.60 (2H, m), 3.66- 3.74 (1H, m), 4.02 (3H, s), 4.60 (1H, s), 7.39 (1H, s), 7.76 (1H, s), 8.06 (1H, q), 8.20 (1H, s), 8.33 (1H, d), 8.46 (1H, d), 8.52 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.30 (1H, s); m/z: (ES+),

[M+H]+ = 520.2

Example 121

5-(Methylamino)-3-r(6-methyl-5.7-dihvdropynOlor3.4-blpyri din-3-vDaminol-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(a) tert-ButyL^-brpmp-S^-dihydrppyrrolofS _^ d-bJpyridine-e-carbpxylate DMAP (92 mg, 0.75 mmol) was added to a solution of 3-bromo-6,7-dihydro-5H-pyrrolo[3,4- bjpyridine (500 mg, 2.51 mmol), di-/er/-butyl dicarbonate (0.29 mL, 1.3 mmol), and DIPEA (1.32 mL, 7.54 mmol) in DCM (10 mL). The resulting solution was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford tert-butyl 3-bromo-5,7- dihydropyrrolo[3,4-b]pyridine-6-carboxylate (0.576 g, 77%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.47 (9H, s), 4.46 - 4.56 (2H, m), 4.57 - 4.68 (2H, m), 8.01 - 8.10 (1H, m), 8.58 (1H, d). m/z\ (ES+), [M+H]+ = 301.1

{b)Tert:Butyl.3-[£3 _: methpxyca^onyl-6 _: (^methylaminoJ-5-(3-methylimidazo[4,5-cJpyridin _: 7- ylJpyrazin-2:ylJaminp]. _: 5,7 _:: dihydrppyiTplp[3 _J _4-b]pyridine-6 _: carbpxylate Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of tert-butyl 3-bromo-5,7- dihydropyrrolo[3,4-b]pyridine-6-carboxylate (190 mg, 0.64 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), and cesium carbonate (104 mg, 0.320 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford tert-butyl 3-[[3-methoxycarbonyl-6-(methylamino)-5-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazin-2-yl]amino]-5,7-dih ydropyrrolo[3,4-b]pyridine-6- carboxylate (0.155 g, 91%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.48 (9H, s), 2.90 (3H, d), 3.85 (3H, s), 4.02 (3H, s), 4.54 (2H, d), 4.64 (2H, d), 7.98 (1H, s), 8.27 (1H, d), 8.50 (1H, s), 8.54 (1H, s), 8.83 (1H, d), 9.05 (1H, s), 10.42 (1H, s). m/r. (ES+), [M+H]+ = 532.2

£cJ.M_ethyJ__3-(6 ₁ 7-di_hy_dro_-5H _: pyrroJp_[3 _J 4-b]pyri_din-3-yj_am_i_npJ _: _5_-(m_ethyJ_amin_o)-6-(3 _: methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carboxylate tert-Butyl 3-[[3-methoxycarbonyl-6-(methylamino)-5-(3-methylimidazo[4,5 -c]pyridin-7- yl)pyrazin-2-yl]amino]-5,7-dihydropyrrolo[3,4-b]pyridine-6-c arboxylate (147 mg, 0.280 mmol) was added to 4 M HC1 in 1,4-dioxane (3.0 mL, 12 mmol). The resulting solution was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by Cl 8 reverse phase chromatography, using 5-100% MeCN-water as eluent, to afford methyl 3-(6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylamino)-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.115 g, 96%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.86 (3H, d), 3.84 (3H, s), 4.14 (3H, s), 4.46 (2H, t), 4.59 (2H, d), 7.61 (1H, d), 8.34 (1H, d), 8.72 (1H, s), 8.92 (1H, d), 9.03 (1H, s), 9.66 (1H, s), 10.14 (1H, s), 10.51 (1H, s). m/r (ES+), [M+H]+ = 432.4

_. (dJ _. Methy! _. 5 _.2 (nieihyJamino)-3 ₇ [(6-methyl-5J _T dihxdropyrrolo{3 ₁ 4 _r bJpyridiri ₇ 3-yl)airiino]-6-

_. (3 _.T rnethyJirn!dazoL4,5 _T c]pyridin-7:yJJnyrazine-2-carboxylate

Sodium triacetoxyborohydride (248 mg, 1.17 mmol) was added to a solution of methyl 3-(6,7- dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylamino)-5-(methylamino)- 6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (101 mg, 0.230 mmol) and 35 wt% aqueous formaldehyde (100 mg, 1.17 mmol) in MeOH (5 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)- 3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino]-6- (3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.101 g, 97%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.89 (6H, br s), 3.70 - 3.90 (7H, m), 4.02 (3H, s), 7.96 (1H, s), 8.15 (1H, d),

8.47 - 8.54 (2H, m), 8.72 (1H, s), 9.06 (1H, s), 10.37 (1H, s). m/r (ES+), [M+H]+ = 446.2 _. (e) _. 5 ₇ (MethyJaminp)-3 _r £(6-methyl-5J _: dihydjppyrroJp[3,4-b]pyridinr3-y!)amino]-6 _: (3- methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide formate salt 7 N Methanolic ammnonia (5.0 mL, 35 mmol) was added to methyl 5-(methylamino)-3-[(6- methyl-5,7-dihydropynOlo[3,4-b]pyridin-3-yl)amino]-6-(3-meth ylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (83 mg, 0.19 mmol). The resulting suspension was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, using decreasingly polar mixtures of MeCN-HiO as eluent and 0.1% formic acid as modifier, to afford 5-(methylamino)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridi n-3- yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-c arboxamide formate salt (62 mg, 71%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.57 (3H, s), 2.90 (3H, d),

3.88 (2H, s), 3.96 (2H, s), 4.00 (3H, s), 7.41 (1H, s), 7.77 (1H, s), 7.99 (1H, br q), 8.12 (1H, s), 8.14 (1H, s), 8.50 (1H, s), 8.71 (2H, s), 9.01 (1H, s), 11.53 (1H, s). m/r (ES+), [M+H]+ = 431.3

Example 122

3-r(6-Ethyl-5.7-dihvdropyrrolor3.4-blpyridin-3-vnaminol-5 -(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

{a)MethyIJ _. :X(6_-ethyl-5 _J 7-dihydropyrrolp[3 ₁ 4 _: b}p _j ridin _: 3 _r y_l)amino]-5-(methy_laminp) _. :6-(3- PiethyJi nudazqbd^cjpyri din- 7 ryjjpy razi ne-2 _: carbpxylate

Sodium triacetoxyborohydride (295 mg, 1.39 mmol) was added to a mixture of methyl 3-(6,7- dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylamino)-5-(methylamino)- 6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (Example 121(c)) (120 mg, 0.28 mmol) and 40 wt% aqueous acetaldehyde (153 mg, 1.39 mmol) in DCM (5 mL). The resulting solution was stirred at 25 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM, to afford methyl 3-[(6- ethyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino]-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.102 g, 80%) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 1.14 (3H, t), 2.73 (2H, q), 2.88 (3H, d), 3.80 - 3.86 (5H, m), 3.88 - 3.93 (2H, m), 4.01 (3H, s), 7.96 (1H, br q), 8.17 (1H, d), 8.49 (1H, s), 8.53 (1H, s), 8.70 (1H, d), 9.05 (1H, s), 10.36 (1H, s); m/z\ (ES+), [M+H]+ = 460.3 _. (bJ _. 3rI(6-Ethyl-5 _j 7-dihydrppyrrplp[3,4 _T b}pyridin-3-yJ)aminp] ₇ 5-(rnethyJaminp)-6-(3 _: methyhmbdazpb4 ₁ 5 _: c]pyridin-7 _: yl_)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[(6-ethyl-5,7- dihydropyrrolo[3,4-b]pyridin-3-yl)amino]-5-(methylamino)-6-( 3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (91 mg, 0.20 mmol). The resulting suspension was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[(6-ethyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (20 mg, 21%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.12 (3H, t), 2.72 (2H, q), 2.92 (3H, d), 3.81 (2H, s), 3.90 (2H, s), 4.01 (3H, s), 7.42 (1H, s), 7.78 (1H, s), 8.02 (1H, br q), 8.15 (1H, d), 8.52 (1H, s), 8.69 (1H, d), 8.73 (1H, s), 9.03 (1H, s), 11.52 (1H, s); m/r. (ES+), [M+H]+ = 445.2 Example 123

3-r(6-Isopropyl-5.7-dihvdropyrrolor3.4-b1pyridin-3-vnamin o1-5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-yl )pyrazine-2-carboxamide formate salt

(aJ.Methylp.rllOrisoprppyJ-SJ-dihydropyrroJpfj _^ d-bJpyridm-j-yjjaminoj-ii^methyJairijnpJ-i)-

_. (3 _T rnethyJirri!dazoL4,5 _T c]pyridin-7:yJ) _. pyrazine-2-carbpxylate

Sodium triacetoxyborohydride (246 mg, 1.16 mmol) was added to methyl 3-(6,7-dihydro-5H- pynOlo[3,4-b]pyridin-3-ylamino)-5-(methylamino)-6-(3-methyli midazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (100 mg, 0.23 mmol) and acetone (170 μL, 2.32 mmol) in MeOH (5 mL). The resulting solution was stirred at 25 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford methyl 3-[(6-isopropyl-5,7-dihydropyrrolo[3,4-b]pyridin-3- yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxylate

(0.093 g, 85%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.15 - 1.22 (6H, m), 2.90 (3H, d), 3.01 - 3.15 (1H, m), 3.80 - 3.90 (5H, m), 3.92 - 4.12 (5H, m), 7.98 (1H, br q), 8.33

(1H, s), 8.50 (1H, s), 8.53 (1H, s), 8.84 (1H, s), 9.06 (1H, s), 10.46 (1H, s). m/z: (ES+),

[M+H]+ = 474.4

_. (bJ _.J rliO-Isopropyb^Y _. -dihydropyrrploLj^-blpy'ridin-JryJJarninoJ-S-Xrnethyla minoj-OrQ: methybmidazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide formate salt Methyl 3-[(6-isopropyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino] -5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (85 mg, 0.18 mmol) was added to ammonia of solution in MeOH (5 mL) at 25°C under air. The resulting mixture was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 3-[(6-isopropyl-5,7-dihydropyrrolo[3,4-b]pyridin-3-yl)amino] -5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide formate salt (20 mg, 22% yield) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) 5 1.13 (6H, d), 2.72 - 8.03 (1H, br q), 8.17 (2H, s), 8.53 (1H, s), 8.69 (1H, d), 8.73 (1H, s), 9.04 (1H, s), 11.54 (1H, s); m/z·. (ES+), [M+H]+ = 459.2

Example 124 3-r4-r(Dimethylamino)methyl1anilino1-5-(methylamino)-6-(3-me thylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

_. (a) _.. N :I4 1 _. ,3 _: D i ox qlan- 2_-yJ_)p_h_enyJ Jforrn am i _d_e

Formic acid (4.64 mL, 121 mmol) was added dropwise to acetic anhydride (11.4 mL, 121 mmol). The resulting solution was stirred at 50 °C for 2 hours. The reaction was allowed to cool to room temperature and then added dropwise to a solution of 4-(l,3-dioxolan-2- yl)aniline (1.66 g, 10.1 mmol) in THF (51 mL) at 0 °C. The resulting mixture was stirred at 25 C for 2 hours. The reaction was then diluted with EtOAc and washed with saturated aqueous sodium bicarbonate. The layers were separated and the aqueous layer was extracted four times with EtOAc (50 mL each). The organic layers were combined, dried over Na ₂ S0 ₄ , and concentrated to afford N-[4-(l,3-dioxolan-2-yl)phenyl]formamide (1.94 g, 100%) as a beige solid.

_. (bJ _. Methy! _. 6 _.2 chJorq-3:[4 _T (l,3-diqxqlan-2-yJ)an!lino]-5-(methylarninq)pyrazine-2 -carboxylate 60 wt% Sodium hydride in oil (0.400 g, 10.0 mmol) was added portionwise to a solution of N-[4-(l,3-dioxolan-2-yl)phenyl]formamide (1.93 g, 10.0 mmol) in DMF (46 mL). Methyl 6- chloro-3-fluoro-5-(methylamino)pyrazine-2-carboxylate (1.50 g, 6.83 mmol) was added. The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then quenched with water and concentrated. The resulting residue was dissolved in DCM, washed with water, dried over Na ₂ S0 ₄ , filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[4-(l,3- dioxolan-2-yl)anilino]-5-(methylamino)pyrazine-2-carboxylate (0.810 g, 33%) as a yellow solid; ¾NMR (500 MHz, DMSO-de) d 2.94 (3H, d), 3.81 (3H, s), 3.89 - 3.96 (2H, m), 4.01 - 4.07 (2H, m), 5.68 (1H, s), 7.39 (2H, d), 7.71 (2H, br d), 7.83 - 7.96 (1H, m), 10.33 (1H, s); m/z: (ES+), [M+H]+ = 365.1

{c) _. 6:Chloro:3-[4-(l,3-dAOxplan-2:yl)anilino} _: 5-(methylamino)pyrazine:2-carboxamide 7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 6-chloro-3-[4-(l,3- dioxolan-2-yl)anilino]-5-(methylamino)pyrazine-2-carboxylate (410 mg, 1.12 mmol). The resulting suspension was stirred at 110 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 6-chloro-3-[4-(l,3-dioxolan-2-yl)anilino]-5-(methylamino)pyr azine-2- carboxamide (0.230 g, 59%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) d 2.94 (3H, d), 3.87 - 3.97 (2H, m), 3.99 - 4.07 (2H, m), 5.66 (1H, s), 7.31 - 7.42 (3H, m), 7.61 (1H, br s), 7.68 (2H, d), 7.82 - 7.93 (1H, m), 11.49 (1H, s); m/z: (ES+), [M+H]+ = 350.4 {¾.3rI4rXL3:PioxQlan _: 2-yl)anilino]-5 _: (methylaminp)-6-(3-methylimidazo[4 _J 5-cJpyridin _: 7- yljpyrazine-2 _: carbpxamide

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (0.172 g, 0.810 mmol), bis(pinacolato)diboron (0.514 g, 2.03 mmol), cataCXium A Pd G3 (0.059 g, 0.080 mmol), cataCXium A (0.029 g, 0.080 mmol), and potassium acetate (0.238 g, 2.43 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (3.5 mL) was added and the reaction was stirred at 80 °C for 24 hours. The reaction was allowed to cool to room temperature and set aside.

6-Chloro-3-[4-(l,3-dioxolan-2-yl)anilino]-5-(methylamino) pyrazine-2-carboxamide (230 mg, 0.66 mmol), Pd(dppf)Ch DCM complex (96 mg, 0.13 mmol), and cesium fluoride (300 mg, 1.97 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borlyation mixture was added via syringe. The resulting reaction was stirred at 90 °C for 1 hour. The reaction was then concentrated. The resulting residue was diluted with DCM and washed with water. The layers were separated and the aqueous layer was extracted with 3 : 1 chloroform/IPA. The combined organic layers were dried over NaiSCE, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford 3-[4-(l,3-dioxolan-2- yl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin -7-yl)pyrazine-2-carboxamide (0.130 g, 44%) as an orange solid; 1HNMR (500 MHz, DMSO-d6) 2.95 (3H, d), 3.89 - 3.95 (2H, m), 4.00 (3H, s), 4.03 - 4.10 (2H, m), 5.68 (1H, s), 7.39 (2H, br d), 7.45 - 7.66 (1H, m), 7.80 (2H, br d), 7.84 - 7.93 (1H, m), 7.96 - 8.09 (1H, m), 8.51 (1H, s), 8.74 (1H, s), 9.02 (1H, s), 11.60 (1H, s); m/z: (ES+), [M+H]+ = 447.4

{ej _. Sr^rFormylaniUngi-S^methylaminpJ-e-Q-methylimidazo^S-c Jpyridin-Y-yO _. pyrazine-?- carboxamide hydrochloride

2 N Aqueous HC1 (10 mL, 20 mmol) was added to 3-[4-(l,3-dioxolan-2-yl)anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (125 mg, 0.28 mmol). The resulting mixture was stirred for 1 hour. The reaction was then concentrated to afford 3-(4-formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine- 2-carboxamide hydrochloride (0.120 g, 98%) as a reddish/orange solid; 'H NMR (500 MHz, DMSO-d6) 2.99 (3H, s), 4.14 (3H, s), 7.59 (1H, br s), 7.78 (1H, br s), 7.89 (2H, d), 8.07 (3H, d), 8.98 (1H, s), 9.05 (1H, s), 9.57 (1H, s), 9.86 (1H, s), 12.07 (1H, s); m/z: (ES+), [M+H]+ = 403.2

{O _. ^L^tCDimethylaminpJmethylJanilinoJ-S-imethylaming^e-^^ methylimidazo^ _^ S- c]pyridin:7 _: yljpyrazine-2 _: carbpxamide bjs-fprmate.salt

2 M Dimethylamine in THF (270 μL, 0.54 mmol) was added to a solution of 3-(4- formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxamide (60 mg, 0.14 mmol) in DMF (1.0 mL), MeOH (0.4 mL), and acetic acid (0.1 mL). The resulting mixture was stirred at 65 °C for 1 hour, then cooled to 0 °C. Sodium triacetoxyborohydride (79 mg, 0.37 mmol) was added. The resulting mixture was stirred at 25 C for 15 minutes. The reaction was then concentrated. The resulting residue was redissolved in DMF (1.6 mL). Dimethylammonium chloride (82 mg, 1.0 mmol), DIPEA (175 μL, 1.00 mmol), and acetic acid (0.1 mL) were added. The resulting mixture was stirred at 70 °C for 1 hour. The reaction was then allowed to cool to room temperature. Sodium triacetoxyborohydride (79 mg, 0.37 mmol) was added. The resulting mixture was stirred for 5 minutes, then filtered and concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 5-25% MeCN-HiO as eluent, and 0.1% formic acid as modifier to afford 3-[4-[(dimethylamino)methyl]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide bis-formate salt (28 mg, 43%); 1H NMR (500 MHz, DMSO-d6) 2.26 (6H, s), 2.95 (3H, br d), 3.53 (2H, s), 4.00 (3H, s), 7.29 (2H, br d), 7.37 (1H, br s), 7.69 - 7.82 (3H, m), 7.99 (1H, br q), 8.17 (2H, s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.54 (1H, s); m/z: (ES+), [M+H]+ = 432.3 Example 125

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-(pyrrc>lidin-l- ylmethvDanilinolpyrazine-2-carboxamide bis-formate salt Pyrrolidine (41 μL, 0.50 mmol) was added to a mixture of 3-(4-formylanilino)-5-

(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyraz ine-2-carboxamide (50 mg, 0.12 mmol) and acetic acid (0.1 mL) in DCE (1.24 mL) and MeOH (0.41 mL). The resulting mixture was stirred at 65 °C for 1 hour, then cooled to 0 °C. Sodium triacetoxyborohydride (79 mg, 0.37 mmol) was added. The resulting mixture was stirred at 25 C for 5 minutes. The reaction was then concentrated. The resulting residue was redissolved in DMF (1.6 mL).

Additional pyrrolidine (41 μL, 0.50 mmol) and acetic acid (0.1 mL) were added. The resulting mixture was then stirred at 70 °C for 1 hour. The reaction was then allowed to cool to room temperature. Additional sodium triacetoxyborohydride (79 mg, 0.37 mmol) was added. The reaction was then filtered and the filtrate was concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 5-25% MeCN-LhO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(pyrrolidin-l-ylmethy l)anilino]pyrazine-2- carboxamide bis-formate salt (12 mg, 22%); ¾NMR (500 MHz, DMSO-d6) 1.63 - 1.78 (4H, m), 2.53 - 2.66 (4H, m), 2.95 (3H, d), 3.67 (2H, s), 4.00 (3H, s), 7.30 (2H, br d), 7.36 (1H, s), 7.75 (3H, d), 7.99 (1H, br q), 8.25 (3H, br s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.53

(1H, s); m/z: (ES+), [M+H]+ = 458.2

Example 126

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4- (morpholinomethvDanilinolpyrazine-2-carboxamide

£aj Methyl.5-(methy]aminpJ-6 _: (3-nieLhyJimidazoL4J-c]pyridin.-7 _: yl). _: 3-[4: {morphplingmethyl)anilinoJpyrazine-2:carboxylate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-[(4-bromophenyl)methyl]morpholine (82 mg, 0.32 mmol), and cesium carbonate (313 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-

(morpholinomethyl)anilino]pyrazine-2-carboxylate (0.117 g, 75%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.30 - 2.43 (4H, m), 2.93 (3H, d), 3.44 (2H, s), 3.54 - 3.63 (4H, m), 3.84 (3H, s), 4.02 (3H, s), 7.30 (2H, d), 7.78 (2H, d), 7.95 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.46 (1H, s); m/z\ (ES+), [M+H]+ = 489.2 {b).5-(Methylambn.o) _: .6-(.3-methylbmidazp[4 _: _5-cJpyridin _: .7.-yl).-3 _: b4- {rnorpholingmethyl)anilino]pyrazine-2:carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(morpholinomethyl)ani lino]pyrazine-2-carboxylate (91 mg, 0.19 mmol). The resulting suspension was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures ofMeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 6-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-((4-

(morpholinomethyl)phenyl)amino)pyrazine-2-carboxamide (30 mg, 33%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.36 (4H, t), 2.96 (3H, d), 3.42 (2H, s), 3.58 (4H, t), 4.01 (3H, s), 7.27 (2H, d), 7.37 (1H, s), 7.72 - 7.78 (3H, m), 8.00 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.53 (1H, s); m/z\ (ES+), [M+H]+ = 474.4 Example 127

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-r(4-methylpiperazin-l- vDmethyl1anilino1pyrazine-2-carboxamide

£aj Methyl.5-(methy]aminoJ-6 _: (3-nieLhyJimidazoL4J-c]pyridin.-7 _: yl). _: 3-[4:j;(4- JI ¹ ethyl.pi perazin- l. _: y.l Jm ethyl Jan il i npjpy razi n e-2-carlyqxy.late

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), l-[(4-bromophenyl)methyl]-4-methyl-piperazine (86 mg, 0.32 mmol), and cesium carbonate (313 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-25% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxylate (0.092 g, 57% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.24 (3H, s), 2.54 - 2.76 (8H, m), 2.93 (3H, d), 3.32 (2H, s), 3.84 (3H, s), 4.02 (3H, s), 7.31 (2H, d), 7.81 (2H, d), 7.95 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.48 (1H, s). m/z\ (ES+), [M+2H] ²⁺ = 251.6

{b).5-(Methylamino) _: 6-(3-methylimidazo[4 _: 5-cJp.yridin _: 7-yl)-3 _: £4-jX4 _: methy.lpiperazin-l _: yjjmethyjjanij j _n ojp.y razi n e-2-carb_qx_amj.de form ate sal. t

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxylate (70 mg, 0.14 mmol). The resulting suspension was stirred at 80 °C for 2 days.

The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[( 4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide formate salt (25 mg, 33%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.19 (3H, s), 2.25 - 2.53 (8H, m), 2.96 (3H, d), 3.42 (2H, s), 4.01 (3H, s), 7.25 (2H, d), 7.36 (1H, s), 7.70 - 7.81 (3H, m), 8.00 (1H, br q), 8.18 (1H, br s), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.52 (1H, s). m/r. (ES+), [M+H]+ = 487.4

Example 128

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-(2-oxa-6-azaspiror3.31heptan- (aj _. Methyl _. 5:(methylaminpJ-6:(3-rriethyJirnidazo[4,5-c]pyridin-7 _T y!i _T 3-[4-(2 _: pxa-6 _T azaspirg[3..3]heptan-6 _: ylmethyl)anilino]pyrazine-2-carbpxy.late

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 6-(4-bromobenzyl)-2-oxa-6-azaspiro[3.3]heptane (86 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting suspension was stirred at 100 °C for 8 hours. The reaction was then concentrated. The crude product was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (2-oxa-6- azaspiro[3.3]heptan-6-ylmethyl)anilino]pyrazine-2-carboxylat e (0.040 g, 25% yield) as a yellow solid, m/z: (ES+), [M+H]+ = 501.3

{b) _. 5 _. -(Methylaminp):6-(3-methylimidazp[4,5-clpyridin _: 7-yl)-3 _: [4-(2-pxa:6- azaspiro[3. _. 3]heptan-6 _: ylmethyl)anilinp]pyrazine-2-carbpxamide _. bis:fprmate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-oxa-6-azaspiro[3.3 ]heptan-6- ylmethyl)anilino]pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 24 hour. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Xselect CSH OBD column, 5- 20% MeCN-fhO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-oxa-6-azaspiro[ 3.3]heptan-6- ylmethyl)anilino]pyrazine-2-carboxamide bis-formate salt (9.0 mg, 13% yield) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.95 (3H, d), 3.31 (4H, s), 3.48 (2H, s), 4.02 (3H, s), 4.61 (4H, s), 7.21 (2H, d), 7.40 (1H, s), 7.73 (2H, d), 7.77 (1H, s), 7.99 (1H, br q), 8.18 (2H, s), 8.53 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.53 (1H, s); m/z: (ES+), [M+H]+ = 486.3.

Example 129 and 130 5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r4-r rel-nR)-l-(4- methylpiperazin-l-vPethyllanilinolpyrazine-2-carboxamide formate salt and 5- ( ^' methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-rrel-(lS)-l-(4-methylpiperazin- l-vDethyllanilinolpyrazine-2-carboxamide formate salt {4) _. l:Methyl-4 _: ^rel:XlRJ _r i-(4^rompphenyl)ethyl]piperazine and _.. l:methyl-4-[rel-(lS):l-(4- bromgphenyljethyQpiperazine

Thionyl chloride (4.44 g, 37.3 mmol) was added to a solution of (4-bromophenyl)methanol (5.00 g, 24.9 mmol) in DCM (2 mL). The resulting mixture was stirred at 25 °C for 4 hours. The reaction was then concentrated. A solution of 1-methylpiperazine (4.98 g, 49.7 mmol) in MeCN (2 mL) was added to the residue. The resulting mixture was stirred at 25 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford racemic l-[l-(4- bromophenyl)ethyl]-4-methyl-piperazine (2.00 g, 28%) as a yellow oil. This material was further purified by preparative chiral HPLC, using a 5 micron, 2.12 cm x 25 cm, Lux 5u Cellulose-4, AXIA packed column, using isocratic 17% MeOH-sCCh as eluent, and 2 mM ammonia as modifier, to afford l-methyl-4-[rel-(lR)-l-(4-bromophenyl)ethyl]piperazine (0.400 g, 5.6% yield) and l-methyl-4-[rel-(lS)-l-(4-bromophenyl)ethyl]piperazine (0.400 g, 5.6%), each as a yellow oil; 1HNMR (300 MHz, DMSO-d6) d 1.25 (3H, d), 2.30 - 2.56 (11H, m), 3.41 (1H, q), 7.17 - 7.34 (2H, m), 7.45 - 7.58 (2H, m); m/z: (ES+), [M+H]+ =

283.1

{bJJ _. MethyL5^(iliethxlAining)-6-(3 _: methylimidazQ^4 ₁ 5 _: c]pyridin-7 _: yl)-3-[4-[rel-(lR)-l-(4 _: methydpjperazin-l _: yl)ethyl] _. aniling]pyrazine: _. 2-carboxylate

Methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (111 mg, 0.350 mmol) was added to a suspension of l-methyl-4-[rel-(lR)-l-(4- bromophenyl)ethyl]piperazine (200 mg, 0.71 mmol), cesium carbonate (690 mg, 2.12 mmol) and BrettPhos Pd G3 (64 mg, 0.070 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel- (lR)-l-(4-methylpiperazin-l-yl)ethyl]anilino]pyrazine-2-carb oxylate (0.080 g, 22%) as a yellow solid; lHNMR (300 MHz, DMSO-d6) d 1.31 (3H, d), 2.26 (3H, s), 2.25 - 2.47 (4H, m), 2.94 (3H, d), 3.39 - 3.52 (5H, m), 3.84 (3H, s), 4.02 (3H, s), 7.29 (2H, d), 7.74 - 7.88 (2H, m), 7.95 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.48 (1H, s). m/z : (ES+),

[M+H]+ = 516.3

£c!J.5:(MethyJamj;ng). _: 6-(3 _: methyh;midazgI4 ₁ 5-clpyjidin _: 7 _r yJJ _r %L4-dreJ-(.! R) _: j. _r ^- methy_lpiperazin-l _: yl)ethyllaniling]pyrazine _: 2-carbgxamide formate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[rel-(lR)-l-(4-methyl piperazin-l- yl)ethyl]anilino]pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 2-15% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[r el-(lR)-l-(4-methylpiperazin- l-yl)ethyl]anilino]pyrazine-2-carboxamide formate salt (26 mg, 39%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.30 (3H, d), 2.19 (3H, s), 2.24 - 2.56 (8H, m), 2.97 (3H, d), 3.38 (1H, q), 4.02 (3H, s), 7.26 (2H, d), 7.38 (1H, s), 7.72 - 7.80 (3H, m), 8.02 (1H, br q),

8.17 (1H, s), 8.53 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.54 (1H, s). m/z : (ES+), [M]+ = 501.5 {b2J _. Methyl 5-(methylaming)-6-(3 _: methylimidazg^4 ₁ 5 _: c]pyridin-7 _: yl)-3-[4-[rel-(lR)-l-(4 _: methylpiperazin-l _: yl)ethyl] _. aniling]pyrazine: _. 2-carbgxylate Cesium carbonate (345 mg, 1.06 mmol) was added to a suspension of (R)-l-(l-(4- bromophenyl)ethyl)-4-methylpiperazine (200 mg, 0.71 mmol), methyl 3-amino-6-(3-methyl- 3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazine-2-car boxylate (111 mg, 0.35 mmol), and BrettPhos Pd G3 (32.0 mg, 0.04 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel- (lS)-l-(4-methylpiperazin-l-yl)ethyl]anilino]pyrazine-2-carb oxylate (0.080 g, 22%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.31 (3H, d), 2.26 (3H, s), 2.25 - 2.47 (4H, m), 2.94 (3H, d), 3.39 - 3.52 (5H, m), 3.84 (3H, s), 4.02 (3H, s), 7.29 (2H, d), 7.74 - 7.88 (2H, m), 7.95 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.48 (1H, s); m/z\ (ES+),

[M+H]+ = 516.3

£c2)_5-(m_ethy]_ami_npJ-6:(_3-m_et_hyJ_im_i_d_azob4,5_-c Jpyridin_-7:y]).:3-[4:Irej-(l R)_-l_ _: (_4- methyJ.pjperazin-J_ _: yl)ethyllanihng]pyrazme _: 2-carboxamide formate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[rel-(lS)-l-(4-methyl piperazin-l- yl)ethyl]anilino]pyrazine-2-carboxylate (60 mg, 0.12 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 2-15% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[r el-(lS)-l-(4-methylpiperazin- l-yl)ethyl]anilino]pyrazine-2-carboxamide formate salt (26 mg, 39%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.30 (3H, d), 2.19 (3H, s), 2.24 - 2.56 (8H, m), 2.97 (3H, d), 3.38 (1H, q), 4.02 (3H, s), 7.26 (2H, d), 7.38 (1H, s), 7.72 - 7.80 (3H, m), 8.02 (1H, br q),

8.17 (1H, s), 8.53 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.54 (1H, s); m/z\ (ES+), [M+H]+ = 501.5

Examples 131 and 132

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-rrel-(TR)-l- morpholinoethyllanilinolpyrazine-2-carboxamide formate salt and 5-(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-vD-3-r4-rrel-(TS)-l-morpholino ethyllanilinolpyrazine-2- carboxamide formate salt

{aXl:Bromo:4-Xl-chlorpethyr)benzene

Thionyl chloride (2.72 mL, 37.3 mmol) was added to a solution of l-(4-bromophenyl)ethanol (5.00 g, 24.9 mmol) in DCM (50 mL). The resulting solution was stirred at 25 °C for 4 hours. The reaction was then concentrated. The resulting residue was redissolved in EtOAc (50 mL) and washed once with saturated aqueous sodium bicarbonate (50 mL) and twice with brine (50 mL). The organic layer was dried over NaiSCL, filtered, and concentrated to afford 1- bromo-4-(l-chloroethyl)benzene (5.1 g, 93% yield) as a colorless oil. 1H NMR (300 MHz, Chloroform-d) d 1.83 (3H, d), 5.04 (1H, q), 7.25 - 7.33 (2H, m), 7.46 - 7.52 (2H, m). Poor behavior by LCMS.

_. (b) _. 4 - [rel - ( 1 R)- l _. : _. (4:Bromophenyl)ethyl] morpholine and 4- [rel _T (l S)- \-(4- bromgphenyljethyQmorpholine

Potassium iodide (0.113 g, 0.680 mmol) was added to a solution of l-bromo-4-(l- chloroethyl)benzene (3.00 g, 13.7 mmol), morpholine (1.43 g, 16.4 mmol) and triethylamine (5.7 mL, 41 mmol) in MeCN (30 mL). The resulting solution was stirred at 60 °C for 50 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-petroleum ether as eluent, to afford 4-[l-(4- bromophenyl)ethyl]morpholine (2.60 g, 70%) as a colorless oil. This material was purified further by chiral SFC, using a 3 micron, 4.6 mm x 50 mm, ChiralPak AD3 column, isocratic 20% MeOH-sCCh as eluent, and 0.1% diethylamine as modifier, to afford 4-[rel-(lR)-l-(4- bromophenyl)ethyl]morpholine (227 mg, 27% yield) and 4-[rel-(lS)-l-(4- bromophenyl)ethyl]morpholine (231 mg, 27% yield), each as a colorless oil. 4-[rel-(lR)-l-(4-bromophenyl)ethyl]morpholine: 1HNMR (400 MHz, Chloroform-d) d 1.33 (3H, d), 2.28 - 2.44 (2H, m), 2.47 - 2.58 (2H, m), 3.29 (1H, q), 3.63 - 3.77 (4H, m), 7.18 - 7.27 (2H, m), 7.42 - 7.49 (2H, m). m/z: (ES+), [M+H]+ = 272.1 4-[rel-(lS)-l-(4-bromophenyl)ethyl]morpholine: 1H NMR (400 MHz, Chloroform-d) d 1.33 (3H, d), 2.29 - 2.43 (2H, m), 2.45 - 2.57 (2H, m), 3.29 (1H, q), 3.61 - 3.77 (4H, m), 7.20 - 7.25 (2H, m), 7.43 - 7.49 (2H, m). m/r (ES+), [M+H]+ = 272.1

{ciXMethyl _. 5-(methylamino)-6 _: (3-methylimidazo[4 _J 5-c]pyridin-7:yl):3 _. -[4:Irel-(lR)-l _: i??oiEhplinoethyl]anilino]pyrazine _: 2-carboxylate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-[rel-(lR)-l-(4-bromophenyl)ethyl]morpholine (103 mg, 0.380 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [rel-(lR)-l- morpholinoethyl]anilino]pyrazine-2-carboxylate (0.127 g, 79% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.30 (3H, d), 2.22 - 2.47 (4H, m), 2.94 (3H, d), 3.33 - 3.42 (1H, m), 3.50 - 3.62 (4H, m), 3.84 (3H, s), 4.02 (3H, s), 7.29 (2H, d), 7.79 (2H, d), 7.97 (1H, br q), 8.50 (1H, s), 8.55 (1H, s), 9.05 (1H, s), 10.47 (1H, s). m/r (ES+), [M+H]+ = 503.3 £dlJ.X-fMethyl_amin_oJ-6-(_3_-methyj_im_i_dazp[4,X-cJpyridi ri _: 7_-y_l)_-3:b4 _: J_rel_ _: _(l_R)-l_- morphplinoethyl ]anilino]pyrazine. _: 2-carbpxamide. formate _, salt

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[rel-(lR)-l-morpholin oethyl]anilino]pyrazine-2- carboxylate (103 mg, 0.200 mmol). The resulting solution was stirred at 80 C for 20 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[r el-(lR)-l- morpholinoethyl]anilino]pyrazine-2-carboxamide formate salt (18 mg, 17%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.29 (3H, d), 2.24 - 2.35 (2H, m), 2.34 - 2.44 (2H, m), 2.97 (3H, d), 3.34 - 3.37 (1H, m), 3.51 - 3.59 (4H, m), 4.01 (3H, s), 7.26 (2H, d), 7.37 (1H, s), 7.71 - 7.81 (3H, m), 8.01 (1H, br q), 8.14 (1H, s), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.53 (1H, s); m/r (ES+), [M+H]+ = 488.4

_. (c2) jyiethyl X-(methyJaminp)^6:(%methyJirnidazp[4,5-c]pyridin-7 _T yl) _T 3-[4rIrel-(j S)- l- i??oiphplinpethyl]anilinp]pyrazine _: 2-carbpxylate BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-[rel-(lS)-l-(4-bromophenyl)ethyl]morpholine (103 mg, 0.380 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 15% MeOH-DCM, to afford methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[r el-(lS)-l- morpholinoethyl]anilino]pyrazine-2-carboxylate (0.119 g, 74% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.30 (3H, d), 2.20 - 2.49 (4H, m), 2.94 (3H, d), 3.33 - 3.41 (1H, m), 3.52 - 3.62 (4H, m), 3.84 (3H, s), 4.02 (3H, s), 7.29 (2H, d), 7.79 (2H, d), 7.97 (1H, br q), 8.50 (1H, s), 8.55 (1H, s), 9.05 (1H, s), 10.47 (1H, s). m/z\ (ES+), [M+H]+ = 503.3 {d2) _. 5_-XMethylaminoJ-6-(3_-methylimidazq[4,5-cJpyridin-7-y l)-3_ _: ^4 _: [rel: _. (lS)-l: morphplinoethyl ]anilino]pyrazine _: 2-carbpxamide. formate _, salt

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[rel-(lS)-l-morpholin oethyl]anilino]pyrazine-2- carboxylate (102 mg, 0.20 mmol). The resulting solution was stirred at 80 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 x 100 mm XSelect CSH Prep C18 OBD column, decreasingly polar mixtures of MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[r el-(lS)-l- morpholinoethyl]anilino]pyrazine-2-carboxamide (18 mg, 17%) formate salt as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.29 (3H, d), 2.25 - 2.33 (2H, m), 2.35 - 2.45 (2H, m), 2.97 (3H, d), 3.32 (1H, q), 3.50 - 3.60 (4H, m), 4.01 (3H, s), 7.19 - 7.30 (2H, m), 7.37 (1H, s), 7.66 - 7.83 (3H, m), 8.02 (1H, br q), 8.16 (1H, s), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.53 (1H, s); m/z: (ES+), [M+H]+ = 488.4

Example 133

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r 4-ri-methyl-l-(4- methylpiperazin-l-vPethvnanilinolpyrazine-2-carboxamide

(a) 2r{[L-(4rBiomophenyl) _r l-methyl-ethyJJ-(2-hydrpxyethyl)amino]ethanol 2-Bromoethanol (1.284 g, 10.28 mmol) was added to a solution of 2-(4-bromophenyl)propan- 2-amine (1.100 g, 5.14 mmol) and DIPEA (4.50 mL, 25.7 mmol) in MeCN (40 mL). The resulting mixture was stirred at 120 °C for 16 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM (200 mL) and washed twice with brine (200 mL each). The organic layer was dried over NaiSCL, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petr oleum ether as eluent, to afford 2-[[l-(4-bromophenyl)-l-methyl-ethyl]-(2-hydroxyethyl)amino] ethanol (1.20 g, 77%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.27 (6H, s), 2.44 (4H, t), 3.31 — 3.36 (4H, m), 4.40 (2H, t), 7.47 (4H, s); m/z: (ES+), [M+2+H]+ = 303.9 £bJ.j.rIl.:(4-B_romopheny!)-j.-methy_!-ethyJJ-4-m_et_hyJ-pi perazi_ne Methanesulfonyl chloride (455 mg, 3.97 mmol) was added to a solution of 2-[[l-(4- bromophenyl)-l-methyl-ethyl]-(2-hydroxyethyl)amino]ethanol (600 mg, 1.99 mmol) and DIPEA (1.04 mL, 5.96 mmol) in DCM (10 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 1 hour. The reaction was then concentrated. The resulting residue was taken up in IPA (10 mL). tert-Butyl ammonium iodide (73 mg, 0.20 mmol) and 2M methanolic methanamine (10 mL, 20 mmol) were sequentially added. The resulting mixture was stirred at 90 °C for 16 hours. The reaction was then concentrated, redissolved in DCM (100 mL), and washed three times with brine (lOOmL each). The organic layer was dried over NaiSCL, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petroleum ether as eluent, to afford l-[l-(4-bromophenyl)-l-methyl-ethyl]-4-methyl- piperazine (0.700 g, quantitative) as a yellow oil; 1H NMR (400 MHz, DMSO-d6) d 1.27 (6H, s), 2.39 (3H, s), 2.45 - 2.50 (4H, m), 2.62 - 2.68 (4H, m), 7.40 - 7.47 (2H, m), 7.47 - 7.54 (2H, m); m/z: (ES+), [M+2+H]+ = 299.0

£c).M_ethyJ__5-(m_ethy]_ami_nq)-6 _: (_3-m_et_hy_Hmi_d_azob4,_5-cJpyridi_n-7:y!).:3-[4 _: £l_ _: _methyJ_ _: _l_-(4_- methyJ.pjperazin-ri_ _: yl)ethyllaniling]pyrazine _: 2-carboxylate Cesium carbonate (312 mg, 0.960 mmol) was added to methyl 3-amino-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol), l-[l-(4- bromophenyl)-l-methyl-ethyl]-4-m ethyl-piperazine (95 mg, 0.32 mmol) and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)-3-[4-[l -methyl- 1 -(4- methylpiperazin-l-yl)ethyl]anilino]pyrazine-2-carboxylate (0.050 g, 30% yield) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.34 (6H, s), 2.31 (3H, s), 2.94 (3H, d), 3.83 (3H, s), 4.02 (3H, s), 7.49 (1H, s), 7.81 (2H, d), 7.96 (1H, d), 8.51 (1H, s), 8.54 (1H, s), 9.06 (1H, s), 9.93 (1H, s), 10.50 (1H, s). The piperazine CH protons were buried under solvent, m/z: (ES+), [M+H]+ = 430.2

{¾.5rXM9thy!amino) _: 6_-(_3-methylimidazo[4 _: _5_-cJp _j ridin _: _7_-yl)_-3 _: £4-Ll_-m_ethyl-l-(4 _:

.91?thylp.i perazi n_- 1 _: y 1 Jethy 1 lanj H.n o]py razi_ne:_2-carb ox am _i_de

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[l-methyl-l-(4-methyl piperazin-l- yl)ethyl]anilino]pyrazine-2-carboxylate (60 mg, 0.11 mmol). The resulting mixture was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 250 mm YMC-Actus Triart C18 column, 30-35% MeCN-H?0 as eluent, and 0.1% ammonium bicarbonate as modifier to afford 5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)-3-[4-[l -methyl- 1 -(4- methylpiperazin-l-yl)ethyl]anilino]pyrazine-2-carboxamide (6.0 mg, 10%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.30 (6H, s), 2.14 (3H, s), 2.26 - 2.37 (4H, m), 2.34 - 2.48 (4H, m), 2.97 (3H, d), 4.02 (3H, s), 7.35 (1H, s), 7.43 (2H, d), 7.70 - 7.78 (2H, m), 7.75 (1H, s), 8.02 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.51 (1H, s); m/z: (ES+), [M- C ₅ H _II N ₂ ]+ = 415.2

Example 134

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vO-3-r 4-(T-methyl-l-morpholino- ethvDanilinolpyrazine-2-carboxamide

Step _. J _. . 4 _: 0 _: (4-Brompphenyl)- 1 :methyl _: ethylJmprpholine l-Bromo-2-(2-bromoethoxy)ethane (130 mg, 0.56 mmol) was added to a solution of 2-(4- bromophenyl)propan-2-amine (100 mg, 0.47 mmol), and DIPEA (250 mg, 1.93 mmol) in acetonitrile (20 mL). The resulting mixture was stirred at 120 °C for 16 hours. The reaction was then concentrated. The crude residue was purified by silica gel chromatography, using 0- 80% EtOAc-petroleum ether as eluent, to afford 4-[l-(4-bromophenyl)-l-methyl- ethyljmorpholine (0.090 g, 68%) as a yellow liquid; 1HNMR (400 MHz, CDCh) d 1.33 (6H, s), 2.26 - 2.58 (4H, m), 3.65 - 3.71 (4H, m), 7.43 (4H, s); m/z: (ES+), [M+H]+ = 284.0 .(b) _. Methy! _. 5 _. -(niethylarnino)-6 _r (3 _: methyJirnidazp[4 ₁ 5 _: c]pyridin-7ryI)r3 _. -[4-(j-methyl-l- tPPrphplino _T ethyl)anilinpJpyrazine-2-carbpxylate

BrettPhos Pd G3 (43 mg, 0.050 mmol) was added to a mixture of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (150 mg, 0.48 mmol), 4-[l-(4-bromophenyl)-l-methyl-ethyl]morpholine (204 mg, 0.720 mmol), and cesium carbonate (468 mg, 1.44 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)-3-[4-(l -methyl- 1- morpholino-ethyl)anilino]pyrazine-2-carboxylate (0.110 g, 45%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.32 (6H, s), 2.40 (4H, br s), 2.94 (3H, d), 3.57 (4H, br s), 3.84 (3H, s), 4.02 (3H, s), 7.49 (2H, d), 7.79 (2H, d), 7.94 - 8.03 (1H, m), 8.50 (1H, s), 8.55 (1H, s), 9.05 (1H, s), 10.47 (1H, s); m/z: (ES+), [M-C ₄ H ₈ NO]+ = 430.3

{c) _. 5:{Methylaminq)-6-(3-methyhmidazo^4 ₁ 5-c] _. pyridin-7-yl)-3-[4-(l _. -methyl- T-mpipholinp- .9thyljanriinpjpyrazine-2 _: carbpxamide 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 6-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-((4-(2-morphol inopropan-2- yl)phenyl)amino)pyrazine-2-carboxylate (110 mg, 0.21 mmol). The resulting suspension was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by C18 reverse phase chromatography, using 5-40% MeCN-FfO as eluent and 0.1% formic acid as modifier, to afford a yellow solid. This material was further purified by preparative SFC using a 5 micron, 20 x 250 mm DAICEL DCpak P4VP column, 0-40% MeOH-sCCh as eluent, and 0.5% ammonia as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l-methyl-l-morpholin o-ethyl)anilino]pyrazine-2- carboxamide (19 mg, 18%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.31 (6H, s), 2.35 - 2.44 (4H, m), 2.97 (3H, d), 3.54 - 3.64 (4H, m), 4.02 (3H, s), 7.36 (1H, s), 7.43 - 7.50 (2H, m), 7.71 - 7.79 (3H, m), 8.01 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.52 (1H, s); m/z: (ES+), [M-C ₄ H ₈ NO]+ = 415.2

Example 135

(R)-3-((4-((3-Fluoropyrrolidin- l -yl jmethyl )phenyl)amino)-6-(3-methyl-3H-imidazor4.5- clpyridin-7-vn-5-(methylamino)pyrazine-2-carboxamide formate salt A mixture of 3-(4-formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7- yl)pyrazine-2-carboxamide (50 mg, 0.12 mmol), (R)-3-fluoropyrrolidine (33 mg, 0.37 mmol), and acetic acid (two drops) in DMF (1.5 mL) and MeOH (0.5 mL) was stirred at 65 °C for 1 hour. The reaction was then cooled to 0 °C. Sodium triacetoxyborohydride (87 mg, 0.41 mmol) was added. The resulting mixture was stirred at 25 °C for 16 hours. The reaction was then filtered. The filtrate was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm XSelect CSH Cl 8 column, decreasingly polar mixtures of MeCINMhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[[(3R)-3-fluoropyrrolidin-l-yl]methyl]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide formate salt (4.0 mg, 6.2%) as a yellow solid; 1HNMR (500MHz, DMSO-d6) d 1.74 - 1.96 (1H, m), 2.07 - 2.22 (1H, m), 2.27 - 2.34 (1H, m), 2.56 (1H, br dd), 2.69 - 2.81 (2H, m), 2.95 (3H, d), 4.00

(3H, s), 5.10 - 5.27 (1H, m), 6.60 (2H, br s), 7.26 (2H, d), 7.35 (1H, br s), 7.68 - 7.80 (3H, m), 7.99 (1H, br q), 8.35 (1H, s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.50 (1H, s); m/z\ (ES+), [M+H]+ = 476.1

Example 136 3-r4-rr(3S)-3-Fluoropyrrolidin-l-yllmethyllanilinol-5-(methy lamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

A mixture of 3-(4-formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7- yl)pyrazine-2-carboxamide (50 mg, 0.12 mmol), (S)-3-fluoropyrrolidine (33 mg, 0.37 mmol) and acetic acid (two drops) in DMF (1.5 mL) and MeOH (0.5 mL) was stirred at 60 °C for 1 hour. The reaction was then cooled to 0 °C. Sodium triacetoxyborohydride (79 mg, 0.37 mmol) was added. The resulting mixture was stirred at 25 °C for 16 hours. The reaction was then filtered. The filtrate was purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm XSelect CSH Cl 8 column, decreasingly polar mixtures of MeCN-FhO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[[(3S)-3-fluoropyrrolidin-l-yl]methyl]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide formate salt (3.5 mg, 5.4%) as a yellow solid; ¾ NMR (500MHz, DMSO-de) d 1.74 - 1.96 (1H, m), 2.07 - 2.22 (1H, m), 2.27 - 2.34 (1H, m), 2.56 (1H, br dd), 2.69 - 2.81 (2H, m), 2.95 (3H, d), 4.00 (3H, s), 5.10 - 5.27 (1H, m), 6.60 (2H, br s), 7.26 (2H, d), 7.35 (1H, br s), 7.68 - 7.80 (3H, m), 7.99 (1H, br q), 8.35 (1H, s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.50 (1H, s); m/z\

(ES+), [M+H]+ = 476.1

Example 137

3-r4-r(3.3-Difluoropyrrolidin-l-vnmethyllanilinol-5-(meth ylamino)-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide formate salt

A mixture of 3-(4-formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7- yl)pyrazine-2-carboxamide (50 mg, 0.12 mmol), 3,3-difluoropyrrolidine (40 mg, 0.37 mmol), and acetic acid (two drops) in DMF (1.5 mL) and methanol (0.500 mL) was stirred at 60 °C for 1 hour. The reaction was then cooled to 0 °C. Sodium triacetoxyborohydride (79 mg, 0.37 mmol) was then added. The resulting mixture was stirred at 25 C for 16 hours. The reaction was then filtered. The filtrate was diluted with DMF (1.5 mL) and purified by preparative HPLC, using a 5 micron, 30 mm x 100 mm, Xselect CSH OBD column, 5-15% MeCN-FLO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[(3,3-difluoropyrrolidin-l- yl)methyl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c] pyridin-7-yl)pyrazine-2- carboxamide formate salt (2.0 mg, 3.0%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) d 2.18 - 2.33 (2H, m), 2.68 (2H, br t), 2.85 (2H, br t), 2.95 (3H, d), 3.57 (2H, s), 4.00 (3H, s), 7.26 (2H, d), 7.35 (1H, br s), 7.69 - 7.78 (3H, m), 7.98 (1H, br s), 8.49 (1H, s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.52 (1H, s); m/z (ES+), [M+H]+ = 494.3

Example 138

3-r4-rr(3S)-3.4-Dimethylpiperazin-l-yllmethyllanilinol-5- (methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide tris-formate salt (2S)-1,2-Dimethylpiperazine dihydrochloride (21 mg, 0.11 mmol) was added to a solution of 3-(4-formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxamide hydrochloride (50 mg, 0.11 mmol) and DIPEA (20 μL, 0.11 mmol) in DMF (1.5 mL), MeOH (0.5 mL) and THF (0.5 mL). A catalyic amount of AcOH was added to the reaction (4 drops). The resulting mixture was stirred at 60 °C for 1 h, then cooled to 0 °C. Sodium triacetoxyborohydride (72 mg, 0.34 mmol) was added. The resulting mixture was stirred at room temperature for 16 h. The reaction was then concentrated and purified by MDAP, using a 5 micron, 30 mm x 100 mm, Waters XSelect CSH C18 OBD Prep column, 5 to 25% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford (S)-3-((4-((3,4- dimethylpiperazin-l-yl)methyl)phenyl)amino)-6-(3-methyl-3H-i midazo[4,5-c]pyridin-7-yl)-5- (methylamino)pyrazine-2-carboxamide tris-formate salt (6.0 mg, 9.6% yield) as a yellow solid. ¾ NMR (500MHz, DMSO-de) 0.91 (3H, d), 1.74 (1H, br t), 1.93 - 2.03 (2H, m), 2.04 - 2.12 (5H, m), 2.13 (3H, s), 2.63 - 2.68 (1H, m), 2.95 (3H, d), 4.00 (3H, s), 7.24 (2H, d), 7.35 (1H, br s), 7.65 - 7.79 (3H, m), 7.99 (1H, br q), 8.31 (3H, s), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.50 (1H, s). m/z: (ES+), [M+H]+ = 501.3

Example 139 3-r4-rr(3R)-3.4-Dimethylpiperazin-l-yl1methyl1anilino1-5-(me thylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

(2R)-1,2-Dimethylpiperazine (13 mg, 0.11 mmol) was added to a solution of 3-(4- formylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxamide hydrochloride (50 mg, 0.11 mmol) and DIPEA (60 μL, 0.34 mmol) in DMF (1.0 mL), THF (0.5 mL), and MeOH (0.5 mL). A catalytic amount of AcOH was added (4 drops). The resulting mixture was stirred at 60 °C for 1 hour, then cooled to 0 °C. Sodium triacetoxyborohydride (72 mg, 0.34 mmol) was added. The resulting mixture was stirred at room temperature for 3 days. The reaction was then filtered, concentrated, and purified by MDAP, using a 5 micron, 30 mm x 100 mm, Waters XSelect CSH C18 OBD Prep column, 5 to 25% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[[(3R)-3,4- dimethylpiperazin-l-yl]methyl]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin- 7-yl)py ^raz i ^ne -2-carboxamide formate salt (4.0 mg, 6.4% yield) as a yellow solid. ¾ NMR (500MHz, DMSO-de) 0.91 (3H, d), 1.69 - 1.79 (1H, m), 1.94 - 2.04 (2H, m), 2.05 - 2.11 (2H, m), 2.11 - 2.16 (4H, m), 2.94 (3H, d), 4.00 (3H, s), 6.52 (2H, br s), 7.24 (2H, d), 7.34 (1H, s), 7.74 (3H, s), 7.99 (1H, d), 8.22 (2H, s), 8.50 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.51 (1H, s) m/z: (ES+), [M+H]+ = 501.3

Example 140

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vn-3-r r6-(morpholinomethvn-3- pyridvHaminolpyrazine-2-carboxamide formate salt

_. (aJ _. MMhyl _. 5r(methylairiino)-6:(3-iTiethyJirnidazo[4,5-c]pyridin- 7 _T y!) _T 3-[[6-

{iUorphpHngmethylJ-3-pyndylJaminpJpyrazine-2-carboxy.late

BrettPhos Pd G3 (100 mg, 0.32 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-[(5-bromo-2-pyridyl)methyl]morpholine (164 mg, 0.640 mmol), and cesium carbonate (208 mg, 0.640 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[6 - (morpholinomethyl)-3-pyridyl]amino]pyrazine-2-carboxylate (0.060 g, 38% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 2.41 (4H, t), 2.89 (3H, d), 3.55 (2H, s), 3.58 (4H, t), 3.82 (3H, s), 4.00 (3H, s), 7.41 (1H, d), 7.94 (1H, br q), 8.19 - 8.29 (1H, m), 8.48 (1H, s), 8.51 (1H, s), 8.89 (1H, d), 9.03 (1H, s), 10.40 (1H, s). m/z\ (ES+), [M+H]+ = 490.2 {b).5rXM9thy!aminp) _: 6-(3-methylimidazp[4 _: 5-cJp _j ridin _: 7-yl)-3 _: £[6-(mgrphplinpmethy.l)-3 _: py _. ridyl] _. aming]pyrazine: _. 2-carbgxyli _. c acid

Methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[6 -(morpholinomethyl)- 3-pyridyl]amino]pyrazine-2-carboxylate (60mg, 0.12 mmol) was added to a solution of sodium hydroxide (24.5 mg, 0.610 mmol) in water (5 mL) and MeOH (5 mL). The resulting mixture was stirred at 60 °C for 3 hours. The reaction was then concentrated. The resulting reisdue was purified by reverse phase chromatography, using 5 to 80% MeCN-water as eluent and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[[6-(morpholinomethyl)-3-pyridyl]amino]pyr azine-2-carboxylic acid (0.060 g, quantitative) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 2.40 (4H, s), 2.91 (3H, d), 3.52 (2H, s), 3.58 (4H, t), 3.99 (3H, s), 7.36 (1H, d), 8.11 - 8.31 (1H, m), 8.66 (1H, s),

8.85 (1H, s), 8.95 (1H, s), 13.52 (1H, s). The NH and COOH protons broadened into the baseline, m/z: (ES+), [M+H]+ = 476.2

{9X5 _:i (Methyl^jnq)-6 _:( (3 _: methyHmid^p£4 ₁ 5 _: c]pyridin-7 _r ylJ-3-IX6 _: (ino^holinoinethyl)-3- pyridyllaminglpyrazine^ _. ^-carboxamide formate _, salt

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [[6-(morpholinomethyl)-3- pyridyl]amino]pyrazine-2-carboxylic acid (55 mg, 0.12 mmol) was added to a mixture of HATU (88 mg, 0.23 mmol), DIPEA (100 μL, 0.58 mmol), ammonium chloride (19 mg, 0.35 mmol), DMF (20 mL). The resulting mixture was stirred at 20 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 19 mm x 250 mm XSelect CSH Prep Cl 8 OBD column, 2-10% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[[6-(morpholinomethyl)-3-pyridyl]amino]pyr azine-2-carboxamide formate salt (3.4 mg, 5.8% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 2.32 - 2.46 (4H, m), 2.93 (3H, d), 3.53 (2H, s), 3.56 - 3.60 (4H, m), 4.00 (3H, s), 7.35 - 7.44 (2H, m), 7.74 - 7.81 (1H, m), 7.98 (1H, br q), 8.17 - 8.26 (1H, m), 8.28 (1H, s), 8.51 (1H, s), 8.71 (1H, s), 8.88 (1H, d), 9.02 (1H, s), 11.55 (1H, s). m/z\ (ES+), [M+H]+ = 475.3

Example 141

3-r2-Fluoro-4-r(4-methylpiperazin-l-vnmethyllanilinol-5-( methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

{a) _. l:K4'Bromp-3:flupxQ-phenyl)methyl]-4 _: methyl _: piperazine

Sodium triacetoxyborohydride (10.44 g, 49.26 mmol) was added to a solution of 4-bromo-3- fluoro-benzaldehyde (2.00 g, 9.85 mmol) and 1-methylpiperazine (0.987 g, 9.85 mmol) in DCE (40 mL). The resulting mixture was stirred at 25 C for 5 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM (200 mL) and washed three times with saturated aqueous sodium bicarbonate (200 mL each). The organic layer was dried overNaiSCL, filtered, and concentrated to afford l-[(4-bromo-3-fluoro-phenyl)methyl]-4- methyl-piperazine (1.00 g, 35% yield); 1HNMR (400 MHz, DMSO-d6) d 2.14 (3H, s), 2.17 - 2.52 (8H, m), 3.44 (2H, s), 7.10 (1H, dd), 7.27 (1H, dd), 7.63 (1H, dd); m/z: (ES+), [M+H]+ = 287.2

{bJ _. Methyl _. 3-[2-fluprp:4-[(4-methylpiperazin _: f-yl)methyl]anilinp]-5:(methylaminp)-6-(3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylate l-[(4-Bromo-3-fluoro-phenyl)methyl]-4-methyl-piperazine (220 mg, 0.77 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (200 mg, 0.64 mmol), cesium carbonate (624 mg, 1.91 mmol), and BrettPhos Pd G3 (87 mg, 0.10 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 30% MeOH-DCM as eluent, to afford methyl 3-[2-fluoro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.100 g, 30% yield) as a yellow solid, m/z: (ES+), [M+H]+ = 505.5

(c) 3-[2-Fluoro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[2-fluoro-4-[(4- methylpiperazin-l-yl)methyl]anilino]-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (130 mg, 0.25 mmol). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column using a 5 micron, 30 x 150 mm XB ridge Prep OBD Cl 8 column, 14-44% MeCN-ThO as eluent, and 0.1% ammonium bicarbonate as modifier, to afford 3-[2- fluoro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(methyla mino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (55 mg, 44%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.15 (3H, s), 2.29 - 2.40 (8H, m), 2.96 (3H, d), 3.43 (2H, s), 4.02 (3H, s), 7.11 (1H, d), 7.19 (1H, d), 7.39 (1H, s), 7.77 (1H, s), 8.02 (1H, br q), 8.52 (1H, s), 8.67 (1H, t), 8.74 (1H, s), 9.03 (1H, s), 11.70 (1H, d); m/z: (ES+), [M+H]+ = 505.5

Example 142

3-r3-Chloro-4-r(4-methylpiperazin-l-vnmethyl1anilino1-5-( methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

{¾).l:I(4-Bromp-2-chlprp-phenyl)methylJ _: 4-methyl.-j)iperazine

Sodium triacetoxyborohydride (9.66 g, 45.6 mmol) was added to a solution of 4-bromo-2- chloro-benzaldehyde (2.00 g, 9.11 mmol) and 1 -methylpiperazine (0.913 g, 9.11 mmol) in DCE (40 mL). The resulting mixture was stirred at 25 C for 5 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM (200 mL), then washed three times with saturated aqueous sodium bicarbonate three times (200 mL each) and once with brine (200 mL). The organic layer was dried over NaiSCL, filtered, and concentrated to afford l-[(4-bromo-2-chloro-phenyl)methyl]-4-methyl-piperazine (1.20 g, 43% yield) as an off- white solid; 1H NMR (400 MHz, DMSO-d6) d 2.15 (3H, s), 2.30 - 2.34 (4H, m), 2.39 - 2.43 (4H, m), 3.50 (2H, s), 7.41 (1H, d), 7.53 (1H, dd), 7.68 (1H, d); m/z: (ES+), [M+2+H]+ = 305.1

{¾ _. Methyl _. 3-[3-cMpro-4:L(4 _: methy) _. piperazin-l _: ylJmethylJanilinoJ:5-(methylamino)-6:(3: methyhmidazp[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carboxylate l-[(4-Bromo-2-chloro-phenyl)methyl]-4-methyl-piperazine (242 mg, 0.800 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (250 mg, 0.80 mmol), cesium carbonate (780 mg, 2.39 mmol), and BrettPhos Pd G3 (108 mg, 0.120 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[3-chloro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.130 g, 30%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.35 - 2.45 (4H, m), 2.74 - 2.84 (4H, m), 2.93 (3H, d), 3.65 (3H, s), 3.84 (3H, s), 4.06 (3H, s), 7.44 (1H, d), 7.57 (1H, dd), 7.86 (1H, s), 8.13 (1H, s), 8.34 (1H, d), 8.69 (1H, s), 9.27 (1H, s), 10.55 (1H, s). m/z: (ES+), [M+H]+ = 536.2 {c) _. 3:^3:Chloro:4-[0-methylpiperazin-l-yl)inethjJ]anilino] -5:(methylamino)-6-(3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide formate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[3-chloro-4-[(4- methylpiperazin-l-yl)methyl]anilino]-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (120 mg, 0.22 mmol). The resulting mixture was stirred at 80 °C for 1 day. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 50 x 100 mm XBridge Prep Cl 8 OBD column, decreasingly polar mixtures of MeCINMhO as eluent, and 0.5% formic acid as modifier to afford 3-[3-chloro-4-[(4-methylpiperazin-l-yl)methyl]anilino]-5-(me thylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt (35 mg, 28%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.41 (3H, s), 2.98 (3H, d), 3.56 (2H, s), 4.02 (3H, s), 7.40 (1H, d), 7.45 (2H, m), 7.82 (1H, s), 8.07 (1H, br q), 8.14 (1H, s), 8.34 (1H, d), 8.53 (1H, s), 8.73 (1H, s), 9.04 (1H, s), 11.68 (1H, s). The piperazine CH protons were buried under solvent, m/z: (ES+), [M+H]+ = 521.4

Example 143

3-r2-Fluoro-4-(morpholinomethvnanilino1-5-(methylamino)-6 -(3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide formate salt

{¾)M?thyJ.J.:I2 _: fluoiO-4 _: {mg^holinpmethyl)anilinpJ-5-(methylamino) _: 6-(3- JI ¹ ethyjj _. rnidazg^^^cjpyri din- 7 ryjjpy razi ne-2:carboxylate

BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), 4-(4-bromo-3-fluorobenzyl)morpholine (175 mg, 0.640 mmol), and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[2-fluoro-4-(morpholinomethyl)anilino]-5-(methylamino)-6-( 3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.140 g, 43%) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.37 (4H, d), 2.91 (3H, d), 3.45 (2H, s), 3.57 (4H, d), 3.83 (3H, s), 4.01 (3H, s), 7.15 (1H, d), 7.25 (1H, dd), 8.41 - 8.49 (2H, m), 8.52 (1H, s), 8.62 (1H, t),9.04 (1H, s), 10.66 (1H, s). m/z: (ES+), [M+H]+ = 507. {bJ.3-[2-Huoro-4 _: (mgrpholinpmethyJJanilinpJ-5 _: (meth _j .laminp) _: 6-(3-methylimidazo[4 _: 5- c]pyridin-7 _: yljpyrazine-2 _: carbgxamide fgrmate _. salt

7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 3-[2-fluoro-4- (morpholinomethyl)anilino]-5-(methylamino)-6-(3-methylimidaz o[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (135 mg, 0.270 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 3-[2-fluoro-4-(morpholinomethyl)anilino]-5-(methylamino)-6-( 3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide formate salt (0.060 g, 43%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.39 (4H, t), 2.92 (3H, d), 3.47 (2H, s), 3.57 (4H, d), 3.98 (3H, s), 7.13 (1H, dd), 7.19 - 7.29 (2H, m), 7.73 - 7.83 (2H, m), 8.14 (1H, s), 8.45 (1H, s), 8.61 - 8.68 (2H, m), 8.99 (1H, s), 11.60 (1H, d); m/z\ (ES+), [M+H]+ = 492.3 Example 144

3-r2.3-Difluoro-4-(morpholinomethvnanilino1-5-(methylamin o)-6-(3-methylimidazor4.5- c1pyridin-7-vDpyrazine-2-carboxamide

£4j _. 4:I(4r _. Bi;om_o_-2J_:_d_i_flu_oro-p_heny]J_iTiethyJ2iTiorp_hol _ine

Sodium triacetoxyborohydride (7.19 g, 33.9 mmol) was added to a solution of 4-bromo-2,3- difluoro-benzaldehyde (1.50 g, 6.79 mmol) and morpholine (0.59 g, 6.8 mmol) in 1,2- dichloroethane (10 mL). The resulting mixture was stirred at room temperature for 5 hours, The reaction was then concentrated. The resulting residue was dissolved in dichloromethane (200 mL) and washed three times with saturated aqueous sodium bicarbonate (200 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford 4-[(4- bromo-2,3-difluoro-phenyl)methyl]morpholine (1.7 g, 86%). 1HNMR (300 MHz, DMSO- d6) d 2.26 - 2.41 (4H, m), 3.37 - 3.68 (6H, m), 7.09 - 7.27 (1H, m), 7.39 - 7.54 (1H, m). m/z: (ES+), [M+H]+ = 292.1

{¾ _. 3 _r £(2 _J 3-Difluoro-4 _: (mo^holinomethyl)phenyl)aming)-6-(3 _: methyl _: 3H-imidazg[4 _i 5: c]pyridin _: 7 _: ylJ-5-Xmethylaming)_pyrazine-2-carbgxylic acid

BrettPhos Pd G3 (28.9 mg, 0.03 mmol) was added to a suspension of methyl 3-amino-6-(3- methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazin e-2-carboxylate (100 mg, 0.32 mmol), 4-[(4-bromo-2,3-difluoro-phenyl)methyl]morpholine (112 mg, 0.38 mmol), and cesium carbonate (310 mg, 0.96 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford 3-((2,3-difluoro-4-(morpholinomethyl)phenyl)amino)-6-(3-meth yl-3H-imidazo[4,5- c]pyridin-7-yl)-5-(methylamino)pyrazine-2-carboxylic acid (0.100 g, 61%) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 2.41 (4H, d), 2.93 (3H, d), 3.50 - 3.62 (6H, m), 4.02 (3H, s), 7.20 (1H, t), 7.93 (1H, br q), 8.16 (1H, s), 8.51 (2H, d), 8.61 (1H, s), 9.04 (1H, s) 11.50 (1H, br s). m/z·. (ES+), [M+H]+ = 511.2

_. (cJ _. 3rI2J _r pifluqro _T 4-(niqrpho!inptTiethyl)aniJino]-5 _: (methy!aniinoj ₇ 6-(3-iTiethylimidazp[4 ₃ 5- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide HATU (89 mg, 0.24 mmol) was added to a solution of 3-((2,3-difluoro-4-

(morpholinomethyl)phenyl)amino)-6-(3-methyl-3H-imidazo[4, 5-c]pyridin-7-yl)-5- (methylamino)pyrazine-2-carboxylic acid (100 mg, 0.20 mmol) in DMF (10 mL). The resulting mixture was stirred at room temperature for 10 minutes. Ammonium chloride (31 mg, 0.59 mmol) and DIPEA (41 μL, 0.24 mmol) were added. The resulting mixture was stirred at room temperature for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-EhO as eluent, and 0.1% formic acid as modifier, to afford 3-[2,3-difluoro-4-(morpholinomethyl)anilino]-5-(methylamino) -6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (0.016 g, 16%) as a yellow solid, 1HNMR (DMSO-d6, 400 MHz) d 2.40 (4H, s), 2.96 (3H, d), 3.53 (2H, s), 3.57 (4H, t), 4.02 (3H, s), 7.19 (1H, t), 7.47 (1H, s), 7.83 (1H, s), 8.03 (1H, br q), 8.53 (2H, s), 8.74 (1H, s), 9.05 (1H, s), 11.90 (1H, d). 19F NMR (DMSO-d6, 376 MHz) d -155.40 (d), -143.25 (d). m/r. (ES+), [M+H]+ = 510.3 Example 145

3-r2-Fluoro-4-rrnS.4S)-2-oxa-5-azabicvclor2.2.11heptan-5- yllmethyllanilinol-5-

( ^' methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vDpyra zine-2-carboxamide

_. (a) _. ( LSA _. S)-5r[(4-Bromq-3 _T tlupjq-phenyl)methyl]-2 _: qxa-5-azabicyclo[2,2, l ]heptane (lS,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane (1.50 g, 15.1 mmol) was added to a mixture of 4- bromo-3-fluoro-benzaldehyde (2.56 g, 12.6 mmol) and sodium triacetoxyborohydride (5.34 g, 25.2 mmol) in 1,2-dichloroethane (20 mL). The resulting mixture was stirred at 25 °C for 12 hours. The reaction mixture was then concentrated, diluted with dichloromethane (50 mL), and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford (lS,4S)-5-[(4-bromo- 3-fluoro-phenyl)methyl]-2-oxa-5-azabicyclo[2.2.1]heptane (2.00 g, 55% yield) as a yellow liquid. 1H NMR (300 MHz, DMSO-d6) d 1.55 - 1.86 (2H, m), 2.35 - 2.45 (1H, m), 2.68 - 2.76 (1H, m), 3.49 - 3.57 (1H, m), 3.64 - 3.78 (2H, m), 3.87 - 3.93 (2H, m), 4.33 - 4.38 (1H, m), 7.12 - 7.18 (1H, m), 7.29 - 7.35 (1H, m), 7.59 - 7.66 (1H, m). m/r (ES+), [M+H]+ = 285.9

{b).Methyl.3_-[2-flupro _: 4-[[{lS,4SJ-2-oxa _: 5_-azabicydpl2.2.1]_heptan _: 5 _r ylJmethyl]anilino]-5- {inethylaminoJ-6-X3-methylimidazp[4,5-cJpyridin _: 7-yl)p_yrazine _: 2-carboxylate BrettPhos Pd G3 (158 mg, 0.170 mmol) was added to a suspension of (lR,4R)-5-[(4-bromo- 3-fluoro-phenyl)methyl]-2-oxa-5-azabicyclo[2.2.1]heptane (500 mg, 1.75 mmol), methyl 3- amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine-2-carboxylate (547 mg, 1.75 mmol), and cesium carbonate (1.71 g, 5.24 mmol) in 1,4-dioxane (30 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 12 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-25% MeOH-DCM as eluent, to afford methyl 3-[2-fluoro-4-[[(lS,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]methyl]anilino]-5-(methylamino) -6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.410 g, 45% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.56 - 1.64 (1H, m), 1.79 - 1.83 (1H, m), 2.39 - 2.44 (1H, m), 2.71 - 2.79 (1H, m), 2.91 (3H, d), 3.47 (1H, s), 3.51 - 3.56 (1H, m), 3.69 - 3.72 (2H, m), 3.84 (3H, s), 3.93 (1H, d), 4.02 (3H, s), 4.31 - 4.39 (1H, m), 7.16 - 7.21 (1H, m), 7.24 - 7.29 (1H, m), 7.99 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 8.57 - 8.65 (1H, m), 9.05 (1H, s), 10.65 (1H, d). m/r (ES+), [M+H]+ = 519.2

{c) _. 3:12 _: Huprp-4 _: [[(_lS _.1 4S)-2-oxa-5-azabicyclg[2.2._l]heptan-5 _: ylJmethylJanilinpJ:5- {inpthylaminoJ _: 6-X3-methylimidazp[4,5-cJpyridin _: 7-yl)p_yrazine _: 2-carboxamide 7 N Methanolic ammonia (40 mL, 280 mmol) was added to methyl 3-[2-fluoro-4-[[(lR,4R)- 2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]methyl]anilino]-5-(meth ylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (400 mg, 0.77 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford 3-[2-fluoro-4-[[(l S,4S)-2-oxa-5-azabicyclo[2.2. l]heptan-5-yl]methyl]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxamide (0.110 g,

28% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.56 - 1.63 (1H, m), 1.77 - 1.85 (1H, m), 2.39 - 2.45 (1H, m), 2.71 - 2.79 (1H, m), 2.95 (3H, d), 3.46 (1H, s), 3.50 - 3.56 (1H, m), 3.63 - 3.76 (2H, m), 3.90 - 3.95 (1H, m), 4.02 (3H, s), 4.33 - 4.38 (1H, m), 7.12 - 7.19 (1H, m), 7.20 - 7.28 (1H, m), 7.39 (1H, s), 7.77 (1H, s), 8.02 (1H, br q), 8.52 (1H, s), 8.62 - 8.70 (1H, m), 8.73 (1H, s), 9.03 (1H, s), 11.66 - 11.71 (1H, m). 19F NMR (376 MHz, DMSO) d -130.18. m/z\ (ES+), [M+H]+ = 504.3. [a] ²⁵ _D = +40.75°

Example 146 3-r2-Fluoro-4-rrnR.4R)-2-oxa-5-azabicvclor2.2.11heptan-5-yll methyllanilinol-5- (methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vDpyrazine- 2-carboxamide

_. (aJ _. ( LR,4R) _. -5rI(4-Bromo-3-fluoro-phenyl)niethyJJ _. -2:pxa-5-azabicyclo[2,2, l]heptane DIPEA (0.175 mL, 1.00 mmol) was added to a suspension of l-bromo-4-(bromomethyl)-2- fluoro-benzene (0.268 g, 1.00 mmol), (lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride (0.203 g, 1.50 mmol), and potassium carbonate (0.691 g, 5.00 mmol) in MeCN (4 mL). The resulting mixture was stirred at room temperature for 16 hours. The reaction was then diluted with saturated aqueous ammonium chloride and DCM. The layers were separated and the organic layer was washed sequentially with water and brine, then dried over sodium sulfate, filtered, and concentrated to afford (lR,4R)-5-[(4-bromo-3-fluoro-phenyl)methyl]-2- oxa-5-azabicyclo[2.2.1]heptane (0.285 g, quantitative) as a colorless oil. 1HNMR (500 MHz, DMSO-d6) 1.58 (1H, br d), 1.79 (1H, dd), 2.39 (1H, d), 2.71 (1H, dd), 3.43 (1H, s), 3.51 (1H, dd), 3.63 - 3.77 (2H, m), 3.89 (1H, d), 4.33 (1H, s), 7.13 (1H, dd), 7.30 (1H, dd), 7.61 (1H, t). m/r. (ES+), [M+2+H]+ = 288.9 {¾.Methyl.3-[2-flupro _: 4-[[{lR _^ 4RJ _: 2-oxa _: 5-azabicyclpX2.2.11heptan-5-yl]methyl]anilirio]-5- {inethylaminoJ:6-X3-methylimidazo[4,5-_c]pyridin-7-yl)pyrazi ne:2_-carboxylate BrettPhos Pd G4 (73 mg, 0.080 mmol) was added to a mixture of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (250 mg, 0.80 mmol), (lR,4R)-5-[(4-bromo-3-fluoro-phenyl)methyl]-2-oxa-5-azabicyc lo[2.2.1]heptane (285 mg, 1.00 mmol), and cesium carbonate (780 mg, 2.39 mmol) in 1,4-dioxane (8 mL). The resulting mixture was sparged with argon for 20 minutes, then stirred at 96 °C for 2 hours under argon. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 1% methanolic ammonia as modifier, to afford methyl 3-[2-fluoro-4-[[(lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5- yl]methyl]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c] pyridin-7-yl)pyrazine-2- carboxylate (0.245 g, 59% yield) as an orange foam. m/r. (ES+), [M+H]+ = 519.3 {c) _. 3:12 _: Huorp-4 _: [[(_lR ₃ 4R)-2-oxa-5 _: azabicyclo[2_.2,l]heptan-5 _: ylJmethylJanilinpJ:5- {rnethylaminoJ-6-X3-methylimidazo[4, _. 5-cJpyridin-7-yl)pyrazine: _. 2-carboxamide 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-((4-(((lR,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)methyl)-2-fluorophenyl)amino)-6 -(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-5-(methylamino)pyrazine-2-carboxylate (245 mg, 0.47 mmol). The resulting mixture was stirred at 100 °C for 10 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent and 1% ammonium hydroxide as modifier, to afford 3-((4- (((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)methyl)-2-flu orophenyl)amino)-6-(3-methyl- 3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazine-2-car boxamide (0.104 g, 44% yield) as a bright yellow solid. 1HNMR (500 MHz, DMSO-d6) d 1.58 (1H, d), 1.80 (1H, d), 2.41 (1H, d), 2.74 (1H, d), 2.94 (3H, d), 3.44 (1H, s), 3.52 (1H, d), 3.62 - 3.76 (2H, m), 3.91 (1H, d), 4.00 (3H, s), 4.34 (1H, s), 7.14 (1H, d), 7.22 (1H, d), 7.37 (1H, s), 7.75 (1H, br s), 8.02 (1H, br s), 8.51 (1H, s), 8.64 (1H, t), 8.72 (1H, s), 9.02 (1H, s), 11.66 (1H, s). m/r (ES+), [M+H]+ = 504.2. [a] ²⁵ _D = -37.60°

Example 147

3-r2.3-Difluoro-4-rr(lR.4R)-2-oxa-5-azabicvclor2.2.11hept an-5-yl1methyl1anilino1-5-

(methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vDpyrazi ne-2-carboxamide

£aJl.l.R _r3 4Rh5:I(4rBromp-2J_ _: _di_fluoro-ph_eny!)m_ethyJ2-2-oxa-5-azabi_cyclp|_2.2. IJheptane Sodium triacetoxyborohydride (2.88 g, 13.6 mmol) was added to a solution of 4-bromo-2,3- difluoro-benzaldehyde (1.50 g, 6.79 mmol) and (lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptane (0.673 g, 6.79 mmol) in 1,2-dichloroethane (40 mL). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated, redissolved in dichloromethane, and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over sodium sulfate, filtered and concentrated. The resulting residue was purified by flash C18 chromatography, using 5-100% ACN-water as eluent, and 1% formic acid as modifier, to afford (lR,4R)-5-[(4-bromo-2,3-difluoro-phenyl)methyl]-2-oxa-5- azabicyclo[2.2.1]heptane (1.20 g, 58% yield) as a white solid. 1HNMR (400 MHz, DMSO- d6) d 1.60 (1H, ddt), 1.79 (1H, dd), 2.47 (1H, dd), 2.75 (1H, dd), 3.47 (1H, s), 3.53 (1H, dd), 3.73 - 3.79 (2H, m), 3.90 (1H, dd), 4.35 (1H, t), 7.27 (1H, ddd), 7.49 (1H, ddd). m/z\ (ES+), [M+H]+ = 303.9 (¾.Methyl.3_-[2,3_-difluprp-4-[[(lR _: 4R)_-2 _: pxa-5-azabicyclp[2.2._lJheptan _: 5- y _. UrnethyJJanilinpj _T S-fmethyJaminpf-O^fj^rnethyJirriidazpbd^cJpyridin-y _.T yJJpyrazine-?: carbpxylate

Brettphos Pd G3 (217 mg, 0.24 mmol) was added to a suspension of cesium carbonate (1.56 g, 4.79 mmol), (lR,4R)-5-[(4-bromo-2,3-difluoro-phenyl)methyl]-2-oxa-5- azabicyclo[2.2.1]heptane (485 mg, 1.60 mmol), and methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (500 mg, 1.60 mmol) in 1,4- dioxane (50 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[2,3-difluoro-4- [[(lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]methyl]anilin o]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.300 g, 35% yield) as a yellow solid. 1H NMR (DMSO-d6, 400 MHz) d 1.61 (1H, d), 1.80 (1H, d), 2.78 (1H, d), 2.91 (3H, s), 10.70 (1H, s). m/z (ES+), [M+H]+ = 537.2

_. (cJ _. 3rI2J _r piflupro _T 4-[[(l R ₁ 4Rj _r 2-oxa _: 5-azabicycloX2 _; 2 _; Qheptan _T 5-yl]methyJ]anil|no]-5- {methylaminoJ _j jS-XS-methylimidazo^^S-cJpyndin-Y-y^pyrazine^-carboxam ide 7 N Methanolic ammonia (30 mL, 210 mmol) was added to methyl 3-[2,3-difluoro-4- [[(lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]methyl]anilin o]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (300 mg, 0.56 mmol). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by flash C18 chromatography, using 5-100% ACN-water as eluent, and 1% formic acid as modifier, to afford 3-[2,3-difluoro-4-[[(lR,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]methyl]anilino]-5-(methylamino) -6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (0.113 g, 39% yield) as a yellow solid. 1HNMR (DMSO-d6, 400 MHz) d 1.60 (1H, d), 1.76 - 1.83 (1H, m), 2.78 (1H, dd), 2.95 (3H, d), 3.31(lH,s), 3.48 (1H, s), 3.54 (1H, dd), 3.70 - 3.81 (2H, m), 3.92 (1H, d), 4.02 (3H, s), 4.36 (1H, s), 7.24 (1H, t), 7.45 (1H, s), 7.81 (1H, s), 8.02 (1H, br q), 8.51 (2H, d), 8.73 (1H, s),

9.04 (1H, s), 11.85 (1H, d). 19F NMR (376 MHz, DMSO) d -144.155,-155.523. m/z (ES+), [M+H]+ = 522.3

Example 148

3-r2-Chloro-4-(2-oxa-6-azaspiror3.31heptan-6-ylmethvnanil inol-5-(methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

(a) 6r[(4 _. -Bromp _r l _T ch!pro _T phenyJJmethyl] _: 2-pxa-6-azaspirpj;3 _; 3]heptane Sodium triacetoxyborohydride (2.90 g, 13.7 mmol) was added to a solution of 4-bromo-3- chloro-benzaldehyde (1.00 g, 4.56 mmol) and 2-oxa-6-azaspiro[3.3]heptane hemioxalate (0.657 g, 4.56 mmol) in DCE (40 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 100% EtOAc-petroleum ether as eluent, to afford 6-[(4-bromo-3-chloro-phenyl)methyl]-2-oxa-6-azaspiro[3.3]hep tane (0.800 g, 58% yield) as a yellow oil. 1H NMR (400 MHz, DMSO-d6) d 3.28 (4H, s), 3.46 (2H, s), 4.59 (4H, s), 7.15 (1H, dd), 7.46 (1H, d), 7.68 (1H, d). m/z\ (ES+), [M+2+H]+ = 304.0 _. (bJ _. Me4hy! _.. 3 _.2 [2rchJoro-4-Q.oxa-6-azaspiro[3 _; 3}heptan _: 6-ylrriethyJ)anilinp_l _: 5-(methylamino)-

6-(3 -methy limi dazp[4 _: 5 -c]p.yri din _: 7-y.l)py razine-2-carb pxy.l ate

Brettphos Pd G3 (30 mg, 0.03 mmol) was added to a suspension of 6-[(4-bromo-3-chloro- phenyl)methyl]-2-oxa-6-azaspiro[3.3]heptane (200 mg, 0.66 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (104 mg, 0.330 mmol), and cesium carbonate (323 mg, 0.990 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentration. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford methyl 3-[2-chloro-4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)anilin o]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (0.100 g, 57% yield) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 2.89 (3H, d), 3.31 (4H, s), 3.46 (2H, s), 3.82 (3H, s), 4.00 (3H, s), 4.59 (4H, s), 7.22 (1H, dd), 7.38 (1H, d), 7.97 (1H, br q), 8.48 (1H, s), 8.52 (1H, s), 8.70 (1H, d), 9.04 (1H, s), 10.82 (1H, s). m/z\ (ES+), [M+H]+ = 535.2

{c).3:^2:Chlqro:4^(2rPxa-6 _: azaspirqJ^3,3]heptan-6 _: ylmethyl)anilino]-5 _: (methylaminc)) _: 6-(3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxamide formate salt 7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 3-[2-chloro-4-(2-oxa-6- azaspiro[3.3]heptan-6-ylmethyl)anilino]-5-(methylamino)-6-(3 -methylimidazo[4,5-c]pyridin-

7-yl)py ^raz ine-2-carboxylate (100 mg, 0.19 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 x 150 mm, Xselect CSH OBD column, 2 to 13% MeCN-water as eluent, and 0.05% formic acid as modifier, to afford 3-[2-chloro-4-(2-oxa-6- azaspiro[3.3]heptan-6-ylmethyl)anilino]-5-(methylamino)-6-(3 -methylimidazo[4,5-c]pyridin- 7-yl)py ^raz i ⁿ e-2-carboxamide formate salt (0.037 g, 35% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.94 (3H, d), 3.30 (4H, s), 3.46 (2H, s), 4.02 (3H, s), 4.61 (4H, s), 7.21 (1H, dd), 7.36 (2H, t), 7.77 (1H, d), 8.02 (1H, br q), 8.19 (1H, s), 8.53 (1H, s), 8.71 - 8.78 (2H, m), 9.04 (1H, s), 11.85 (1H, s). m/z\ (ES+), [M+H]+ = 520.2

Example 149

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-(2- morpholinoethvDanilinolpyrazine-2-carboxamide

(a) 4:I?.:(4:Bromopheny.!)ethyl]morpholine

DIPEA (734 mg, 5.68 mmol) was added to a mixture l-bromo-4-(2-bromoethyl)benzene (500 mg, 1.89 mmol), morpholine (248 mg, 2.84 mmol), and potassium iodide (15.72 mg, 0.09 mmol) in MeCN (10 mL). The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by C18 chromatography, using 5- 90% MeCN-EhO as eluent, to afford 4-[2-(4-bromophenyl)ethyl]morpholine (0.410 g, 80%) as a white solid; 1H NMR (Chloroform-d, 400 MHz) d 2.47 - 2.55 (4H, m), 2.55 - 2.61 (2H, m), 2.71 - 2.81 (2H, m), 3.70 - 3.79 (4H, m), 7.10 (2H, d), 7.42 (2H, d); m/z\ (ES+), [M+H]+ = 270.2 i¾.Methyl.5-(methyl^mo)-6 _: 0 _: methyHmidazp£4 ₁ 5 _: c]pyridin-7:yl):3-[4-(2- i?30iphqlinoethyl)anilino]pyrazine _: 2-carboxylate

BrettPhos Pd G3 (173 mg, 0.190 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (300 mg, 0.96 mmol), 4-[2-(4-bromophenyl)ethyl]morpholine (259 mg, 0.960 mmol), and cesium carbonate (936 mg, 2.87 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 15 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (2- morpholinoethyl)anilino]pyrazine-2-carboxylate (0.154 g, 32%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.47 (4H, s), 2.54 (2H, s), 2.73 (2H, t), 2.92 (3H, d), 3.59 (4H, t), 3.83 (3H, s), 4.01 (3H, s), 7.22 (2H, d), 7.69 - 7.75 (2H, m), 8.49 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.39 (1H, s); m/r. (ES+), [M+H]+ = 503.2 (c) 5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (2- morpholinoethyl)anilino]pyrazine-2-carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-morpholinoethyl)an ilino]pyrazine-2-carboxylate (143 mg, 0.280 mmol). The resulting mixture was stirred at 80 °C for 30 hours. The reaction was then concentrated. The resulting residue was purified by preparative LCMS, using a 5 micron, 50 mm x 100 mm, XSelect CSH Cl 8 column, decreasingly polar mixtures of MeCN- ThO as eluent, and 0.1% ammonium carbonate as modifier, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(2-morpholinoethyl)an ilino]pyrazine-2-carboxamide (50 mg, 36%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.38 - 2.46 (4H, m), 2.51 - 2.54 (2H, m), 2.66 - 2.75 (2H, m), 2.95 (3H, d), 3.53 - 3.62 (4H, m), 4.01 (3H, s), 7.20 (2H, d), 7.35 (1H, s), 7.70 (2H, d), 7.74 (1H, s), 8.00 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.45 (1H, s); m/z\ (ES+), [M+H]+ = 448.3

Example 150

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-r2-(4-methylpiperazin-l- vDethyllanilinolpyrazine-2-carboxamide

{a) _. l:I2:(4 _: Brpmophenyl)ethyl]-4-methyl-piperazine Potassium iodide (16 mg, 0.090 mmol) was added to a solution of l-bromo-4-(2- bromoethyl)benzene (500 mg, 1.89 mmol) and 1-methylpiperazine (949 mg, 9.47 mmol) in acetonitrile (10 mL). The resulting solution was stirred at 80 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by C18 reverse phase chromatography, using 5-90% MeCN-H?0 as eluent to afford l-[2-(4-bromophenyl)ethyl]-4-methyl-piperazine (0.317 g, 59%) as a yellow solid; 1H NMR (400 MHz, CDCh) d 2.32 (3H, s), 2.35 - 2.72

(10H, m), 2.73 - 2.81 (2H, m), 7.09 (2H, d), 7.41 (2H, d); m/z: (ES+), [M+H]+ = 283.0 (bJ _. Methyl S-fmethyJaminoj-ti-Q^methyH _. mi _. dazo^d^^cjpyridin-J _. ryJJrJ-tfl-f^-id- methy _. lpiperazin-l _: yl)ethyl] _. aniling]pyrazine: _. 2-carboxylate BrettPhos Pd G3 (116 mg, 0.130 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.64 mmol), l-[2-(4-bromophenyl)ethyl]-4-methyl-piperazine (217 mg, 0.77 mmol) and cesium carbonate (624 mg, 1.91 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [2-(4-methylpiperazin-l- yl)ethyl]anilino]pyrazine-2-carboxylate (0.105 g, 32%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.27 (3H, s), 2.51 - 2.53 (8H, m), 2.54 - 2.58 (2H, m), 2.69 - 2.75 (2H, m), 2.91 (3H, d), 3.83 (3H, s), 4.01 (3H, s), 7.22 (2H, d), 7.72 (2H, d), 7.93 (1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.04 (1H, s), 10.39 (1H, s); m/z: (ES+), [M+H]+ = 516.4 {c) _. 5:{MethylarninQ)-6-(3-methyhmidazo^4 ₁ 5-c] _. pyridin-7-yl)-3-[4-[2-(4-methylpiperazin-l- y]j9thy!lanihng]pyrazme-2-carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[2-(4-methylpiperazin -l-yl)ethyl]anilino]pyrazine-2- carboxylate (90 mg, 0.17 mmol). The resulting solution was stirred at 80 °C for 40 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 50 x 100 mm XSelect CSH Prep C18 OBD column, decreasingly polar mixtures ofMeCN-H ₂ 0 as eluent, and 0.1% ammonium bicarbonate as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[2 -(4-methylpiperazin-l- yl)ethyl]anilino]pyrazine-2-carboxamide (16 mg, 18%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.14 (3H, s), 2.22 - 2.37 (4H, m), 2.37 - 2.47 (4H, m), 2.51 - 2.52 (2H, m), 2.65 - 2.70 (2H, m), 2.94 (3H, d), 4.00 (3H, s), 7.18 (2H, d), 7.34 (1H, s), 7.68 (2H, d), 7.73 (1H, s), 7.98 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 9.01 (1H, s), 11.43 (1H, s); m/z:

(ES+), [M+H]+ = 501.4

Example 151

5-Cvclopropyl-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r4- (pynOlidin-l- ylmethvDanilinolpyrazine-2-carboxamide

(a) I :I( 4 _. - B rom pphenyl j m ethyjjpy rrol i dine

Sodium triacetoxyborohydride (3.18 g, 15.0 mmol) was added to a mixture of 4- bromobenzaldehyde (1.85 g, 10.0 mmol) and pyrrolidine (1.67 mL, 20.0 mmol) in DCM (38 mL). The resulting mixture was stirred at 25 C for 18 hours. The reaction was then quenched by addition of 2 M aqueous NaOH solution and extracted three times with DCM (15 mL each). The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concnetrated to afford l-[(4-bromophenyl)methyl]pyrrolidine (2.45 g, 102%) as a pale yellow oil; 1H NMR (500 MHz, CHLOROFORM-d) d 1.79 (4H, dt), 2.42 - 2.56 (4H, m), 3.57 (2H, s), 7.22 (2H, d), 7.38 - 7.48 (2H, m); m/z\ (ES+), [M+H]+ = 240.0

_. (bJ _. Methy! _. 5 _. -cycJoprqpyl-6-(3 _:iTi ethylimidazpb4 ₁ 5 _: c]py'ridin-7 _r yJ)-3-[4-(pyrrolidin _: l- yJ _. rnethyl)aniJino]pyrazine _: 2-carboxylate

Methyl 3-amino-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine-2- carboxylate (140 mg, 0.43 mmol), l-[(4-bromophenyl)methyl]pyrrolidine (124 mg, 0.520 mmol), BrettPhos Pd G3 (39 mg, 0.040 mmol), and cesium carbonate (422 mg, 1.29 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. 1,4-dioxane (4.3 mL) was added. The resulting mixture was stirred at 110 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, and 1% ammonia as modifier, to afford methyl 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(p yrrolidin-l- ylmethyl)anilino]pyrazine-2-carboxylate (0.078 g, 37%) as a bright yellow dry film; 1H NMR (500MHz, CHLOROFORM-d) d 0.90 - 1.03 (2H, m), 1.22 - 1.34 (2H, m), 1.82 (4H, br s),

1.93 - 2.03 (1H, m), 2.56 (4H, br s), 3.63 (2H, br s), 3.97 (3H, s), 4.01 (3H, s), 7.33 (2H, br d), 7.64 (2H, d), 8.01 (1H, s), 8.68 (1H, s), 8.91 (1H, s), 10.30 (1H, s); m/z\ (ES+), [M+H]+ = 484.2

_. (c) _. 5 ₇ Cyclqpropyl-6 _T (3-methyJirnidazo[4,5-c]pyridin-7 _T y]) _T 3-[4: _. (pyrrplidin-j- yM9thyJ)anilino]pyrazine _: 2-carboxamide 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to a solution of methyl 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(pyr rolidin-l- ylmethyl)anilino]pyrazine-2-carboxylate (78 mg, 0.16 mmol) in methanol (1.5 mL). The resulting mixture was stirred at 100 °C for 4 hours in a Biotage microwave reactor. The reaction was then concentrated to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-[4-(pyrrolidin-l-ylmethyl)anilino]pyrazine-2-carboxami de (0.063 g, 83%) as a yellow solid. 1H NMR (500 MHz, DMSO-d6) d 0.85 - 0.97 (2H, m), 1.01 - 1.13 (2H, m), 1.71 (4H, br s), 1.88 - 1.98 (1H, m), 3.58 (2H, br s), 3.99 (3H, s), 7.29 (2H, br d), 7.61 (2H, br d), 7.85 (1H, br s), 8.10 (1H, br s), 8.44 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 11.29 (1H, s); the 4 pyrrolidine protons alpha to the amine were buried under the DMSO-d6 solvent peak; m z: (ES+), [M+H]+ = 469.2

Example 152

5-Cvclopropyl-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r4- IY4-methylpiperazin-l- vDmethyllanilinolpyrazine-2-carboxamide

{4)M9thyJ _.. 6 _: chlprg-5-c _j. cJ _. opropyl _: 3-[4-[0-methylpiperazin _: l-_yl)methyl]anilino]pyrazine-2- carbpxylate

DIPEA (757 μL, 4.34 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (7.23 mL, 2.17 mmol) and 4-[(4-methylpiperazin-l- yl)methyl]aniline (490 mg, 2.38 mmol) in DMF (8 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature and diluted with EtOAc (50 mL) and brine (50 mL). The layers were separated and the aqueous layer was extracted twice with EtOAc (20 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 6-chloro-5- cyclopropyl-3-[4-[(4-methylpiperazin-l-yl)methyl]anilino]pyr azine-2-carboxylate (0.425 g, 47%) as a yellow solid. 1H NMR (500MHz, DMSO-d6) d 1.15 - 1.26 (2H, m), 1.26 - 1.46 (4H, m), 2.29 (3H, s), 2.58 (1H, ddd), 2.62 - 2.72 (6H, m), 3.55 (2H, s), 4.03 (3H, s), 7.38 (2H, br d), 7.62 (2H, br d), 10.07 (1H, s); m/z: (ES+), [M+H]+ = 416.1 {¾ _. MethyL5_-cyclppxQpyl _: 6 _: X3 _: methy_limida _. ? _.Q H ₁ 5 _: c]pyridin-7 _: yl)-3-[_4-[(4-methylp_iperazin- lryi)methyl]anilino]pyrazine-2-carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (153 mg, 0.720 mmol), bis(pinacolato)diboron (366 mg, 1.44 mmol), cataCXium A Pd G3 (53 mg, 0.070 mmol), cataCXium A (26 mg,

0.070 mmol), and potassium acetate (142 mg, 1.44 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (3.2 mL) was added. The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

Methyl 6-chloro-5-cyclopropyl-3-[4-[(4-methylpiperazin-l-yl)methyl] anilino]pyrazine-2- carboxylate (200 mg, 0.48 mmol), Pd(dppf)C12 dichloromethane complex (39 mg, 0.050 mmol), and cesium fluoride (219 mg, 1.44 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then allowed to cool to room temperature, diluted with water, and extracted three times with 3 : 1 DCM/IPA. The combined organic layers were washed once with 5% aqueous LiCl solution and once with brine. The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 1% ammonia as modifier, to afford methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxylate (0.116, 47%) as a glassy yellow solid; 1H NMR (500MHz, DICHLOROMETHANE-d2) d 0.91 - 0.98 (2H, m), 1.18 - 1.29 (2H, m), 1.87 - 2.00 (1H, m), 2.24 (3H, br s), 2.27 - 2.65 (8H, m), 3.47 (2H, s), 3.95 (3H, s), 3.97 (3H, s), 7.30 (2H, d), 7.63 (2H, d), 7.99 (1H, s), 8.53 (1H, s), 8.91 (1H, s), 10.24 (1H, s); m/r. (ES+), [M+H]+ = 513.2 £cJ.5-Cy_cJ_opropyj-6 _: (_3-met_hyJ_i_mi_d_azob4,_5-c]pyridin_-7:y]).:3-[4 _: I(4-rriethyJpjperazi_n _: _l - yjjmethyjjanij j nojpy razi n e-2-carb_o_x am j_de

7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxylate (116 mg, 0.230 mmol). The resulting suspension was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, and 1% ammonia as modifier, to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[( 4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxamide (32 mg, 28%) as a bright yellow solid. 1H NMR (500 MHz, DMSO-d6) d 0.86 - 0.97 (2H, m), 1.04 - 1.13 (2H, m), 1.87 - 1.97 (1H, m), 2.14 (3H, s), 2.18 - 2.45 (8H, m), 3.41 (2H, s), 3.99 (3H, s), 7.26 (2H, br d), 7.61 (2H, br d), 7.87 (1H, br s), 8.10 (1H, br s), 8.44 (1H, s), 8.54 (1H, s), 9.04 (1H, s), 11.30 (1H, s); m/z\ (ES+),

[M+H]+ = 498.2

Example 153

5-Methoxy-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r4-IY4- methylpiperazin-l- vDmethyl1anilino1pyrazine-2-carboxamide

{4)M9thyJ..6 _: chlprg-5-methpxy-3 _: ^4 _: J^(4-methylpiperazin-l _: yl)methylJanilinc)]pyrazine-2 _: carbpxylate

DIPEA (180 μL, 1.09 mmol) was added to a solution of 4-[(4-methylpiperazin-l- yl)methyl]aniline (205 mg, 1.00 mmol), and methyl 6-chloro-3-fluoro-5-methoxy-pyrazine-2- carboxylate (200 mg, 0.91 mmol) in DMF (0.73 mL). The resulting solution was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature and diluted with brine (5 mL) and DCM (5 mL). The layers were separated and the aqueous layer was extracted three times with DCM (5 mL each). The organic layers were combined and concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% DCM-MeOH as eluent, to afford methyl 6-chloro-5-methoxy-3-[4-[(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxylate (0.093 g, 25%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 2.58 - 2.71 (4H, m), 2.77 - 3.07 (4H, m), 3.53 (2H, br s), 3.67 (3H, s), 3.89 (3H, s), 4.03 (3H, s), 7.31 (2H, br d), 7.65 (2H, br d), 10.22 (1H, s); m/z: (ES+), [M+H]+ = 406.2.

£bJ.Methyj 5_-methg_xy-6 _: (_3-m_et_hyJ_im_i_d_azoL4,5_-cJpy_ridin_-7:y]).:3-I4:I (4-rnethyJpj_peraziri _: _l - yjjmethyjjani! j nojpy razi n_e-2-carb_oxyJ ate Bis(pinacolato)diboron (449 mg, 1.77 mmol), cataCXium A (25 mg, 0.070 mmol), cataCXium A Pd G3 (52 mg, 0.070 mmol), potassium acetate (208 mg, 2.12 mmol), and 7- bromo-3-methyl-imidazo[4,5-c]pyridine (150 mg, 0.71 mmol) were combined in a microwave vial, which was evacuted and backfilled three times with nitrogen. DMF (3.5 mL) was added. The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature and set aside.

Cesium fluoride (104 mg, 0.69 mmol), Pd(dppf)Ch DCM adduct (17 mg, 0.020 mmol), and methyl 6-chloro-5-methoxy-3-((4-((4-methylpiperazin-l-yl)methyl)phe nyl)amino)pyrazine-2- carboxylate (92.7 mg, 0.23 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. Half of the borylation mixture (1.75 mL) from the previous step was added by syringe. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then allowed to cool to room temperature and loaded onto celite. The resulting material was purified by silica gel chromatography, using 0-70% DCM-MeOH as eluent, to afford methyl 5-methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4- methylpiperazin-l-yl)methyl]anilino]pyrazine-2-carboxylate (0.236 g) as a yellow solid that was taken forward without purification m/z: (ES+): [M+H]+ = 503.3. {9X5:Meth xy-6 _: {3 _.: meth Hmid¾oJ4 5 _: c]pyridin-7:yl):3-[4-[(4-methylpiperazin _: l- yjjmethyjjani! j nojpy razi ne-2-carb_ox_amj_de

7 N Methanolic ammonia (7.0 mL, 49 mmol) was added to methyl 5-methoxy-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxylate (262 mg, 0.520 mmol). The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford an orange solid. This material was further purified by preparative HPLC using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 5-25% MeCN-H O as eluent, and 0.2% ammonium hydroxide as modifier, to afford 5-methoxy-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxamide (13 mg, 5.0%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 2.13 (3H, s), 2.18 - 2.44 (8H, m), 3.41 (2H, s), 3.96 (3H, s), 3.97 (3H, s), 7.29 (2H, br d), 7.69 (2H, br d), 7.73 (1H, br s), 7.99 (1H, br s), 8.39 (1H, s), 8.62 (1H, s), 8.98 (1H, s), 11.45 (1H, s); m/z: (ES+), [M+H]+ = 488.3 Example 154

5-(DifluoromethvD-6-(3-methylimidazor4.5-c1pyridin-7-vD-3 -r4-IY4-methylpiperazin-l- {4)MethyIJ _. :amino _: 6-cMoro-5:(dAfluoromethyl)pyrazine-2:carboxylate

TFA (110 μL, 1.43 mmol) was added to a suspension of methyl 3-amino-6-chloro-pyrazine-2- carboxylate (250 mg, 1.33 mmol) and zinc(II) difluoromethanesulfmate (788 mg, 2.67 mmol) in DCM (3 mL) and water (1.2 mL). 70 wt% aqueous tert-butyl hydroperoxide (600 μL, 4.38 mmol) was added dropwise. The resulting mixture was stirred at 25 C for 16 hours, Additional zinc(II) difluoromethanesulfmate (711 mg, 2.41 mmol) was added and 70 wt% aqueous tert-butyl hydroperoxide (600 μL, 4.38 mmol) was added dropwise. The resulting mixture was stirred at 25 C for 60 hours. The reaction was then diluted with DCM (10 mL), quenched with saturated aqueous sodium bicarbonate (40 mL), and stirred vigorously for 2 hours. The layers were separated and the aqueous layer was extracted twice with DCM (20 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford methyl 3-amino-6-chloro-5-(difluoromethyl)pyrazine-2-carboxylate (0.172 g, 54%) as a yellow solid; 1H NMR (500MHz, DMSO-d6) 3.87 (3H, s), 7.07 (1H, t), 7.80 (2H, br s); m/z: (ES+), [M+H]+ = 238.1

£bJ.Methyl__6-chlqrq_-5 _: _(di_tl_uorom_et_hyJJ _: _3_-tl_uoro _: pyrazi_ne _: _2-carboxyjat_e Sodium nitrite (55 mg, 0.80 mmol) was added to a solution of methyl 3-amino-6-chloro-5- (difluoromethyl)pyrazine-2-carboxylate (172 mg, 0.720 mmol) in HF-pyridine (3.0 mL, 87 mmol) at -10 C. The resulting mixture was stirred at 25 C for 30 minutes. The reaction was then diluted with DCM (5 mL) and quenched with water (10 mL). The layers were separated and the aqueous layer was extracted twice with DCM (5 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford methyl 6- chloro-5-(difluoromethyl)-3-fluoro-pyrazine-2-carboxylate (0.147 g, 84%) as a yellow oil; 1H NMR (500MHz, DICHLOROMETHANE-d2) 4.03 (3H, s), 6.94 (1H, t); this intermediate ionized poorly by LCMS. {c)M?thyJ _.. 6 _: chlprg-5-(difluoromethyl) _: 3-[4 _: £(4-methylpiperazin _: l- yjjmethyjjanij j nojpy razi ne-2-carbgxyJate

DIPEA (200 mE, 1.15 mmol) was added to a solution of methyl 6-chloro-5-(difluoromethyl)- 3-fluoro-pyrazine-2-carboxylate (147 mg, 0.610 mmol) and 4-[(4-methylpiperazin-l- yl)methyl]aniline (138 mg, 0.670 mmol) in DMF (2 mL). The resulting solution was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature and diluted with EtOAc (20 mL) and water (30 mL). The layers were separated and the aqueous layer was extracted twice with EtOAc (10 mL each). The combined organic layers were dried over MgS0 ₄ , filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 6-chloro-5- (difluoromethyl)-3-[4-[(4-methylpiperazin-l-yl)methyl]anilin o]pyrazine-2-carboxylate (0.135 g, 52%) as a yellow ochre solid; 1HNMR (500 MHz, DMSO-d6) 2.14 (3H, s), 2.20 - 2.44 (8H, m), 3.42 (2H, s), 3.95 (3H, s), 7.17 (1H, t), 7.28 (2H, br d), 7.60 - 7.68 (2H, m), 10.06 (1H, s); m/z: (ES+), [M+H]+ = 426.4

{dJ _. MethyLS^difluorpmethylX-e-Q^methylimidazg^S^cJpyridin- y^ylJ^-^fl-f^- methy _. lpiperazin-l _: yl)methylJaniling] _. pyrazine-2-carbgxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (101 mg, 0.480 mmol), cataCXium A Pd G3 (35 mg, 0.050 mmol), cataCXium A (17 mg, 0.050 mmol), bis(pinacolato)diboron (183 mg, 0.720 mmol), and potassium acetate (140 mg, 1.43 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (1.8 mL) was added. The resulting mixture was stirred at 100 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

In a separate microwave vial, methyl 6-chloro-5-(difluoromethyl)-3-[4-[(4-methylpiperazin-l- yl)methyl]anilino]pyrazine-2-carboxylate (135 mg, 0.320 mmol), Pd(dppf)Ch (23 mg, 0.030 mmol), and cesium fluoride (144 mg, 0.950 mmol) were combined. The vial was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then allowed to cool to room temperature, diluted with DCM (20 mL), loaded onto Celite, and concentrated. The resulting material was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford methyl 5-(difluoromethyl)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiperazin-l -yl)methyl]anilino]pyrazine-2- carboxylate as a dark yellow solid; 1HNMR (500 MHz, DMSO-d6) 2.14 (3H, s), 2.19 - 2.42 (1H, s), 8.49 (1H, s), 9.10 (1H, s), 10.15 (1H, s); m/z: (ES+), [M+H]+ = 523.3. (e) _. 5-(Difluoromethyl)-6-(3-methylimidazo[4,5-cJpyridin-7- yl)-3:^4 _: [(4-methylpiperazin-l _: y _. Drn ethyl Janil i npjpy razi n e-2-carb qx am i de 7 N Methanolic ammonia (2.50 mL, 17.5 mmol) was added to methyl 5-(difluoromethyl)-6-

(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(4-methylpiper azin-l-yl)methyl]anilino]pyrazine- 2-carboxylate (166 mg, 0.320 mmol). The resulting suspension was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0- 1% ammonia as modifier, to afford 5-(difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)-3-[4-[(4-methylpiperazin-l-yl)methyl]anilino]pyrazine-2- carboxamide (52 mg, 32%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) 2.14 (3H, s), 2.17 - 2.45 (8H, m), 3.43 (2H, s),

4.01 (3H, s), 7.13 (1H, t), 7.29 (2H, d), 7.76 (2H, d), 8.15 (1H, s), 8.45 (1H, s), 8.50 (1H, s),

8.71 (1H, s), 9.08 (1H, s), 11.45 (1H, s); m/z: (ES+), [M+H]+ = 508.3

Example 155

5-(DifluoromethvD-6-(3-methylimidazor4.5-c1pyridin-7-vD-3 -r4-

(morpholinomethvOanilinolpyrazine-2-carboxamide {4)MethyI _. 6-chlprg-5-(difluproinethyl) _: 3-[4-(ingrpholinpmethyl)anilino]pyrazine-2 _: carbpxylate

1 M Lithium bis(trimethylsilyl)amide in THF (1.26 mL, 1.26 mmol) was added to a mixture of tBuXPhos Pd G3 (50 mg, 0.060 mmol), tBuXPhos (27 mg, 0.060 mmol), 4-(4- bromobenzyl)morpholine (194 mg, 0.760 mmol) and methyl 3-amino-6-chloro-5- (difluoromethyl)pyrazine-2-carboxylate (150 mg, 0.63 mmol) in 1,4-dioxane (5 mL). The resulting mixture was sparged with nitrogen for five minutes, then stirred at 50 °C for 2 hours. The reaction was then allowed to cool to room temperature and quenched with saturated aqueous ammonium chloride (5 mL). The layers were separated and the aqueous layer was extracted three times with EtOAc (5 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by flash silica chromatography, using 0-40% MeOH-DCM as eluent, to afford methyl 6-chloro-5- (difluoromethyl)-3-[4-(morpholinomethyl)anilino]pyrazine-2-c arboxylate (0.180 g, 69%) as a brown solid, m/z: (ES+), [M+H]+ = 413.1

{b) _. Methyl _. 5-(difluoroinethjJ)-6 _: (3 _: methylimidazg£4 ₁ 5 _: c]pyridin-7:y _. 0:3-[4-

{iUQrphohngmethylJanilinoJpyrazine-2 _: carbox_ylate

CataCXium A (21.14 mg, 0.06 mmol), bis(pinacolato)diboron (374 mg, 1.47 mmol), CataCXium A Pd G3 (43 mg, 0.060 mmol), potassium acetate (116 mg, 1.18 mmol), 7- bromo-3-methyl-imidazo[4,5-c]pyridine (125 mg, 0.590 mmol), and DMF (2.95 mL) were added to a vial. The resulting suspension was sparged with nitrogen for 5 minutes, then heated to 100 °C for 18 hours. The reaction was then cooled to room temperature and set aside. Pd(dppf)C12 DCM adduct (40 mg, 0.05 mmol), cesium fluoride (147 mg, 0.970 mmol), and methyl 6-chloro-5-(difluoromethyl)-3-[4-(morpholinomethyl)anilino]p yrazine-2-carboxylate (200 mg, 0.48 mmol) were combined in a vial. The borylation mixture was added. The resulting mixture was sparged with nitrogen for 5 minutes, then stirred at 100 °C for 45 minutes. The reaction was then concentrated onto celite. The resulting material was purified by flash silica chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford methyl 5-(difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4- (morpholinomethyl)anilino]pyrazine-2-carboxylate (0.200 g, 81%) as a brown solid, m z: (ES+), [M+H]+ = 510.3

(c) _. 5-(Diflugrgmethyl)-6-(3-rnethylimidazg[4,5-c]pyridin-7 -yl)-3:^4 _:

{iP _.Q rphohngmethylJanilingJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-(difluoromethyl)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(morpholinomethyl)ani lino]pyrazine-2-carboxylate (100 mg, 0.20 mmol). The resulting mixture was stirred at 100 °C in a microwave reactor for 2 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm XSelect CSH C18 column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.2% ammonium carbonate as modifier, to afford 5- (difluoromethyl)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4 -

(morpholinomethyl)anilino]pyrazine-2-carboxamide (0.022 g, 22%) as a yellow solid. 1H NMR (500MHz, DMSO-d6) d 3.46 (2H, s), 3.58 (4H, br d), 4.02 (4H, s), 7.15 (1H, s), 7.33 (2H, d), 7.78 (2H, d), 8.11 - 8.20 (1H, m), 8.46 (1H, s), 8.52 (1H, s), 8.72 (1H, s), 9.10 (1H, s), 11.47 (1H, s); m/z\ (ES+), [M+H]+ = 495.2

Example 156 3-r2-Fluoro-4-(moiOholinomethvDanilino1-5-methoxy-6-(3-methy limidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

(aJ _. Methyl J _. :X2 _r fluoro-4 _r (morpholinpmethyl)aniJino]-5-rriethpxx-6-(3 _:t riethyliiTiidazo{4 ₁ 5- c]pyridm-7 _: yljpyrazine-2 _: carbpxylate BrettPhos Pd G3 (43 mg, 0.050 mmol) was added to a suspension of methyl 3-amino-5- methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-car boxylate (150 mg, 0.48 mmol), 4-[(4-bromo-3-fluoro-phenyl)methyl]morpholine (196 mg, 0.720 mmol), and cesium carbonate (310 mg, 0.95 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[2-fluoro-4-(morpholinomethyl)anilino]-5-methoxy-6-(3-meth ylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.150 g, 62%) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) 5 3.10 - 3.20 (4H, m), 3.67 - 3.79 (4H, m), 3.80 (3H, s), 3.91 (3H, s), 4.01 (3H, s), 4.22 (2H, s), 7.29 (1H, d), 7.40 (1H, d), 8.47 - 8.55 (1H, m), 8.63 (1H, s), 8.77 (1H, s), 9.29 (1H, s). m/z: (ES+), [M+H]+ = 508.2

_. (bJ _.J rl^-Fluoro-ftrfmorphplinpmethylJaniJjnpJ-^methoxy'-b-f j^methylirnidazo^d^^cJpyridin-

7-ylJpyrazine _: 2-carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[2-fluoro-4- (morpholinomethyl)anilino]-5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxylate (150 mg, 0.30 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire C18 column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[2-fluoro-4- (morpholinomethyl)anilino]-5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxamide (0.040 g, 27%) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 2.33 - 2.39 (4H, m), 3.45 (2H, s), 3.53 - 3.62 (4H, m), 3.93 - 4.00 (6H, m), 7.10 - 7.27 (2H, m), 7.77 (1H, s), 8.02 (1H, s), 8.40 (1H, s), 8.48 (1H, t), 8.61 (1H, s), 8.99 (1H, s), 11.65 (1H, s). 19F

NMR (282 MHz, DMSO) d -129.61. m/r (ES+), [M+H]+ = 493.2

Example 157

3-r2.3-Difluoro-4-(morpholinomethvnanilinol-5-methoxy-6-( 3-methylimidazor4.5-clpyridin- 7-vDpyrazine-2-carboxamide

_. (aJ _.J rl^J _. rPiilu _.Q. r _.QT flrfnio _. r _. p _. hQljnpmethylJanilinoJ-S _T meth _. oxy _.T b _. -fj-rnethyJ _. iniidazoH,^- c]pyridin-7 _: yljpyrazine-2 _: carbpxylic _. acid

BrettPhos Pd G3 (43 mg, 0.050 mmol) was added to a suspension of cesium carbonate (466 mg, 1.43 mmol), 4-[(4-bromo-2,3-difluoro-phenyl)methyl]morpholine (209 mg, 0.720 mmol), and methyl 3-amino-5-methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyra zine-2- carboxylate (150 mg, 0.48 mmol) in DMF (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by flash C18-flash chromatography, using 5-40% MeCN-H?0 as eluent, and 0.1% formic acid as modifier, to afford 3-[2,3-difluoro-4-(morpholinomethyl)anilino]-5-methoxy-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylic acid, formic acid salt (0.075 g, 29%) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 2.40 - 2.44 (4H, m), 3.55 - 3.59 (6H, m), 3.91 - 4.00 (6H, m), 7.01 - 7.40 (1H, m), 8.12 (1H, s), 8.22 - 8.39 (2H, m), 8.44 (1H, s), 8.93 (1H, s). m/r (ES+), [M+H]+ = 512.1 £b) 3-((2_,_3-pitluoro-4:_(morp_hoHnom_et_hyJJp_henyJ)a_minp)_-5 _: _methpxy ₇ 6_-_(_3_-methyJ_-3H _: imidazp[4,5_-cJpyridin-7-_yl)pyrazine:2_-carbpxamide Ammonium chloride (21 mg, 0.39 mmol) was added to a solution of DIPEA (110 μL, 0.64 mmol), HATU (59 mg, 0.15 mmol), and 3-[2,3-difluoro-4-(morpholinomethyl)anilino]-5- methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-car boxylic acid, formic acid salt (70 mg, 0.13 mmol) in DMF (15 mL). The resulting mixture was stirred at room temperature for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, XBridge Prep C18 OBD column, decreasingly polar mixtures of MeCN-EhO as eluent, and 10 mmol/L ammonium bicarbonate + 0.1% ammonium hydroxide as modifier, to afford 3-[2,3-difluoro-4- (morpholinomethyl)anilino]-5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxamide (0.024 g, 37%) as a pale yellow solid. 1H NMR (300 MHz, DMSO-d6) d 2.36 - 2.42 (4H, m), 3.50 - 3.60 (6H, m), 3.94 - 4.00 (6H, m), 7.23 (1H, t), 7.83 (1H, s), 8.07 (1H, s), 8.33 (1H, t), 8.40 (1H, s), 8.61 (1H, s), 9.00 (1H, s), 11.81 (1H, s). 19F NMR (282 MHz, DMSO) d -142.86, -154.39. m/r. (ES+), [M+H]+ = 511.2 Examples 158 and 159

5-Methyl -6-(T-methylbenzimidazol-4-vD-3-r4-rrel-(3SV4-methylmorpholi n-3- yllanilinolpyrazine-2-carboxamide and 5-methyl-6-(T-methylbenzimidazol-4-vD-3-r4-rrel- (3R)-4-methylmorpholin-3-yllanilinolpyrazine-2-carboxamide {4)MethyL5:methyl-6-(f-methylbenzimidazol:4 _r yl)-3 _: 0-mQrpholin-3 _: ylanilino)pyrazine:2- carbpxylate

Brettphos Pd G3 (61 mg, 0.070 mmol) was added to a mixture of methyl 3-amino-5-methyl-6- (l-methylbenzimidazol-4-yl)pyrazine-2-carboxylate (200 mg, 0.67 mmol), 3-(4- bromophenyl)morpholine (163 mg, 0.670 mmol), and cesium carbonate (658 mg, 2.02 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholin-3-ylanilino)pyrazine -2-carboxylate (0.240 g, 78 %) as a brown solid; 1H NMR (400 MHz, DMSO-d6) d 2.40 (3H, s), 3.23 - 3.27 (3H, m), 3.75 - 3.87 (1H, m), 3.91 (6H, s), 3.95 - 4.00 (2H, m), 4.36 - 4.44 (1H, m), 7.30 (1H, d), 7.41 (1H, t), 7.63 (2H, d), 7.70 (1H, d), 7.86 (2H, d), 8.24 (1H, s), 10.14 (1H, s), 10.25 (1H, s); m/z\ (ES+), [M+H]+ = 459.2

{¾ _. Methyl _. 5-methyl-6 _: (l-methylbenzimidazol-4-yl)-3 _: ^4 _: (4-methylmorpholin-3- yJjani!!tloJnyrazine-2-carb_oxyJ.ate

37 wt% Aqueous formaldehyde (390 μL, 5.20 mmol) was added to methyl 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholin-3-ylanilino)pyrazine -2-carboxylate (240 mg, 0.52 mmol) in MeOH (10 mL). The resulting mixture was stirred at 25 C for 5 minutes. Sodium triacetoxyborohydride (555 mg, 2.62 mmol) was added. The resulting mixture was stirred at 25 C for 30 minutes. The reaction was then concentrated. The resulting residue was redissolved in EtOAc, then washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-methyl-6-(l-methylbenzimidazol-4-yl)-3-[4-(4-methylmorphol in-3- yl)anilino]pyrazine-2-carboxylate (0.230 g, 93%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.98 (3H, s), 2.17 - 2.32 (1H, m), 2.37 (3H, s), 2.81 (1H, d), 2.95 - 3.04 (1H, m), 3.20 (1H, s), 3.59 (2H, d), 3.81 (1H, d), 3.88 (6H, s), 7.28 - 7.45 (4H, m), 7.62 - 7.69 (1H, m), 7.71 - 7.78 (2H, m), 8.22 (1H, s), 10.07 (1H, s); m/z: (ES+), [M+H]+ = 473.2 {c).5-Methyl-6 _: (l _: methylbenzimidazol-4-yl)-3-£4 _: ^rel-(3S) _: 4-methylmorphglin-3 _: yJj4ni!ihodnyr4zine-2-carbq_xami_de_and_5 _: m_ethyJ_ _: _6_-(l_-methylbenzirnidazqJ-4:yJ) _: _3_-[4_-[re]_- {3RJ:4^inethylmorpholin:3-yl]anilinpJpyrazine-2-cad3oxamide 7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-[4-(4-methylmorpholin-3-yl)anilin o]pyrazine-2-carboxylate (220 mg, 0.47 mmol). The resulting mixture was stirred at 80 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm XBridge Shield RP18 OBD column, 5-20% MeCN-HiO as eluent, and 0.05% ammonium hydroxide as modifier, to afford a yellow solid. This material was further purified by preparative chiral -HPLC, using a 3 micron, 4.6 mm x 100 mm CHIRAL Cellulose-SB column, isocratic 2: 1 : 1 EtOH/hexanes/DCM as eluent, and 0.1% diethylamine as modifier, to afford 5-methyl-6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(3S)-4-meth ylmorpholin-3- yl]anilino]pyrazine-2-carboxamide (38 mg, 18%) and 5-methyl-6-(l-methylbenzimidazol-4- yl)-3-[4-[rel-(3R)-4-methylmorpholin-3-yl]anilino]pyrazine-2 -carboxamide (40 mg, 20%), each as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.00 (3H, s), 2.27 (1H, t), 2.40 (3H, s), 2.83 (1H, d), 3.00 (1H, d), 3.20 - 3.31 (1H, m), 3.62 (2H, t), 3.83 (1H, d), 3.90 (3H, s), 7.33 (2H, d), 7.36 - 7.45 (2H, m), 7.63 - 7.72 (1H, m), 7.75 (2H, d), 7.89 (1H, d), 8.10 (1H, s), 8.25 (1H, s), 11.29 (1H, s); m/z\ (ES+), [M+H]+ = 458.3 Examples 160 and 161

5-Methyl -6-(T-methylbenzimidazol-4-vO-3-r4-rrel-(2R)-4-methylmorphol in-2- yllanilinolpyrazine-2-carboxamide and 5-methyl-6-(T-methylbenzimidazol-4-vO-3-r4-rrel- (2S)-4-methylmorpholin-2-yllanilinolpyrazine-2-carboxamide {4)M9thyJ..5 _: meth _j J-6-(l-methylbenzimidazol _: 4-yl)-3 _: 0-mprpholin-2 _: ylanilino)pyrazine _: 2- carbpxylate

Brettphos Pd G3 (114 mg, 0.130 mmol) was added to a mixture of methyl 3-amino-5-methyl- 6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxylate (250 mg, 0.84 mmol), 2-(4- bromophenyl)morpholine (204 mg, 0.84 mmol), and cesium carbonate (822 mg, 2.52 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-(4-morpholin-2-ylanilino)pyrazine -2-carboxylate (0.260 g, 67%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 2.30 (1H, s), 2.37 (3H, s), 3.10 - 3.24 (3H, m), 3.84 - 4.15 (8H, m), 4.75 (1H, d), 7.28 (1H, dd), 7.38 (3H, dd), 7.68 (1H, dd), 7.79

(2H, d), 8.23 (1H, s), 10.09 (lH,s); m/z\ (ES+), [M+H]+ = 459.2 {b).Methyl.5-methyl-6 _: (l-methylbenzimidazpJ. _: 4- _j j)-3 _: J^4 _: (4-methylmoipholin-2- y]JandinpJpyrazine-2-carbpxylate

Sodium triacetoxyborohydride (277 mg, 1.31 mmol) was added to a mixture of 37 wt% aqueous formaldehyde (36.0 μL, 1.31 mmol) and methyl 5-methyl-6-(l-methylbenzimidazol- 4-yl)-3-(4-morpholin-2-ylanilino)pyrazine-2-carboxylate (200 mg, 0.44 mmol) in MeOH (20 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction mixture was then diluted with DCM (50 mL) and washed three times with water (50 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5 -methyl-6- (l-methylbenzimidazol-4-yl)-3-[4-(4-methylmorpholin-2-yl)ani lino]pyrazine-2-carboxylate (0.150 g, 73%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.85 - 1.97 (1H, m), 1.98 - 2.15 (1H, m), 2.21 (3H, s), 2.39 (3H, s), 2.64 - 2.74 (1H, m), 2.80 - 2.91 (1H, m), 3.61 - 3.77 (1H, m), 3.90 (3H, s), 3.91 (3H, s), 3.94 - 3.97 (1H, m), 4.41 - 4.54 (1H, m), 7.25 - 7.48 (4H, m), 7.72 (3H, dd), 8.24 (1H, s), 10.07 (1H, s); m/r. (ES+), [M+H]+ = 473.2 {c).5-Methyl-6 _: (l _: methylbenzimidazol-4-yl)-3-£4 _: ^rel _r X2R)-4-methylmoipholin-2- ylJ¾nijinoJpyrazine _r 2-carbpxamide and 5 _: methyl:6-(l-methylbenzimidazol-4 _: ylJ _: 3-[4-[rel- {2S)-4 _: methy)mprpholin-2 _: ylJanilinp}pyrazine-2-carbgxamide

7 N Methanolic ammonia (1.50 mL, 10.5 mmol) was added to a suspension of methyl 5- methyl-6-(l-methylbenzimidazol-4-yl)-3-[4-(4-methylmorpholin -2-yl)anilino]pyrazine-2- carboxylate (200mg, 0.42 mmol) in MeOH (1 mL). The resulting suspension was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by chiral HPLC, using a 5 micron, 2 cm x 25 cm ChiralPak IE column, isocratic 20% MeOH- MTBE as eluent, to afford 5-methyl-6-(l-methylbenzimidazol-4-yl)-3-[4-[rel-(2R)-4- methylmorpholin-2-yl]anilino]pyrazine-2-carboxamide (25 mg, 31%) and 5-methyl-6-(l- methylbenzimidazol-4-yl)-3-[4-[rel-(2S)-4-methylmorpholin-2- yl]anilino]pyrazine-2- carboxamide (22 mg, 28%), each as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.82 - 2.01 (1H, m), 2.05 - 2.18 (1H, m), 2.24 (3H, s), 2.41 (3H, s), 2.66 - 2.78 (1H, m), 2.79 - 2.96 (1H, m), 3.59 - 3.76 (1H, m), 3.90 (3H, s), 3.93 - 3.99 (1H, m), 4.43 - 4.50 (1H, m), 7.34 (2H, d), 7.41 (1H, d), 7.43 (1H, s), 7.66 - 7.71 (1H, m), 7.71 - 7.78 (2H, m), 7.91 (1H, s),

8.11 (1H, s), 8.25 (1H, s), 11.29 (1H, s); m/z\ (ES+), [M+H]+ = 458.3

Example 162

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-(4- piperidyloxy)anilinolpyrazine-2-carboxamide £aj Methyl.5-(methy]aminpJ-6 _: (3-nieLhyJimidazoL4J-c]pyridin.-7 _: yl). _: 3-[4-(4: pjperidyJ_oxyJanili_noJpyrazi_ne-2:carboxyJ.ate

BrettPhos Pd G3 (104 mg, 0.110 mmol) was added to a suspension of cesium carbonate (936 mg, 2.87 mmol), tert-butyl 4-(4-bromophenoxy)piperidine-l-carboxylate (853 mg, 2.39 mmol), and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (300 mg, 0.96 mmol) in 1,4-dioxane (20 mL). The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting solid was added to a stirred mixture of thionyl chloride (2.00 mL, 27.4 mmol) in MeOH (20 mL). The resulting mixture was stirred at 60 °C for 10 minutes. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin- 7-yl)-3-[4-(4-piperidyloxy)anilino]pyrazine-2-carboxylate (350 mg, 75%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.76-1.92 (2H, m), 2.02-2.18 (2H, m), 2.87 (3H, d), 3.02 - 3.12 (2H, m), 3.20 - 3.26 (2H, m) 3.82 (3H, s), 4.12 (3H, s), 4.57 - 4.66 (1H, m), 7.04 (2H, d), 7.59 (1H, q), 7.73 (2H, d), 8.70 (1H, s), 8.74-8.88 (1H, m) 8.95 (lH,s), 9.54 (1H, s), 10.35 (1H, s). m/z\ (ES+), [M+H]+ = 489.3

{b).5r£MethyJamino) _: 6_-(_3-methylimidazp[4 _: _5_-cJpyridin _: _7_-yl)_-3 _: £4-(4_- pippridylpxyjanilinpjpyrazine-^carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to a suspension of methyl 6-(3- methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-((4- (piperi din-4- yloxy)phenyl)amino)pyrazine-2-carboxylate (15 mg, 0.03 mmol) in MeOH (2 mL). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column, using a 19 mm x 250 mm, 5 micron, XSelect CSH C18 OBD column, using 8-12% MeCN-H?0 as eluent and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (4- piperidyloxy)anilino]pyrazine-2-carboxamide (5.0 mg, 34%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.65 - 1.74 (2H, m), 2.03 (2H, m), 2.82 - 2.98 (5H, m), 3.09 - 3.19 (2H, m), 4.02 (3H, s), 4.45 - 4.60 (1H, m), 6.94 - 7.03 (2H, m), 7.30 - 7.37 (1H, m), 7.66 - 7.75 (3H, m), 8.01 (1H, br q), 8.34 (1H, s), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.35 (1H, s). m/r. (ES+), [M+H]+ = 474.3

Example 163 3-G4-GP -Acetyl -4-piperidvDoxy1anilino1-5-(methylamino)-6-(3-methylimidazor 4.5-c1pyridin-

7-vnpyrazine-2-carboxamide

{a)MethyIJ _. :X4 _: ^(l-acetyl-4:piperidyl)oxy]anilino]-5 _: _(methylamino)-6-(3-methylimidazo[4 _3. 5- c]pyridin-7 _: yljpyrazine-2 _: carbpxylate

DMAP (2 mg, 0.02 mmol) was added to a solution of triethylamine (0.69 mL, 0.49 mmol), acetic anhydride (33 mg, 0.33 mmol) and methyl 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[4-(4-piperidyloxy)anilino]pyrazine-2-carb oxylate (80 mg, 0.16 mmol) in DCM (20mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then washed three times with water (50 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 3-[4-[(l-acetyl-4-piperidyl)oxy]anilino]-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (80 mg, 92%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.37 - 1.77 (2H, m), 1.88 (2H, d), 2.02 (3H, s), 2.90 (3H, d), 3.05 - 3.25 (1H, m), 3.31 - 3.35 (1H, m), 3.67 (1H, s), 3.83 (3H, s), 3.87 - 3.91 (1H, m), 4.02 (3H, s), 4.31 - 4.77 (1H, m), 7.01 (2H, d), 7.71 (2H, d), 7.93 (1H, d), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.29 (1H, s); m/z: (ES+), [M+H]+ = 531.3 £bJ.3_-[4_-£(_l_-AcetyJ_ _: _4-p_iperi_dyJJ_o_xyJani_li_n_o2 _: _5-(m_et_hyJ_ami_no)_-6 _: _(3-met_hyJ_i_rni_dazo[_4,5- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to a suspension of methyl 3-[4-[(l - acetyl -4-piperidyl)oxy]anilino]-5-(methylamino)-6-(3-methylimidazo [4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (70 mg, 0.13 mmol) in MeOH (20mL). The resulting mixture was stirred at 70 °C for 24 hours. The resulting residue was purified by preparative HPLC Column, using a 19 mm x 250 mm, 5 micron, XSelect CSH C18 OBD column, using 25-35% MeCN-HiO as eluent and 0.1% formic acid as modifier, to afford 3-[4-[(l-acetyl-4- piperidyl)oxy]anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxamide (33 mg, 47%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.56 (2H, m), 1.80 - 2.05 (5H, m), 2.94 (3H, d), 3.17 - 3.31 (2H, m), 3.63 - 3.77 (1H, m), 3.80 - 3.93 (1H, m), 4.02 (3H, s), 4.55 (1H, m), 6.95 - 7.08 (2H, m), 7.34 (1H, d), 7.66 - 7.78 (3H, m), 8.01 (1H, br q), 8.53 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.36 (1H, s). m/z: (ES+), [M+H]+ = 516.2

Example 164 5-(Methylamino)-6-(3-methylimidazc>r4.5-c1pyridin-7-vD-3- r4-r(l -methyl-4- piperidvDoxylanilinolpyrazine-2-carboxamide

£a). Methyl.5:_(m_ethy]_ami_npJ-6:(_3-m_et_hyJ_im_i_d_azp[_4,5_-c ]pyndi_n-7:y!).:3-[4 _: £(_l_-methyj-4 _: piperidyl)oxy]anilinp]pyrazine-2-carbpxylate Sodium triacetoxyborohydride (26 mg, 0.12 mmol) was added to a solution of 35 wt% aqueous formaldehyde (19 μL, 0.25 mmol) and methyl 6-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-5-(methylamino)-3-((4-(piperidin-4-yloxy)phe nyl)amino)pyrazine-2- carboxylate (60 mg, 0.12 mmol) in MeOH (10 mL). The resulting mixture was stirred at 25 °C for 30 minutes. The reaction was then concentrated. The resulting residue was redissolved in DCM (100 mL), and washed three times with brine (50 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l-methyl-4-piperidy l)oxy]anilino]pyrazine-2- carboxylate (0.050 g, 81 %) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.73 - 2.39

(4H, m), 2.77 (3H, s), 2.90 (3H, d), 3.00 - 3.30 (4H, m), 3.83 (3H, s), 4.02 (3H, s), 4.39 - 4.93 (1H, m), 7.05 (2H, d), 7.75 (2H, d), 7.92 (1H, br q), 8.50 (1H, s), 8.54 (1H, s), 9.05 (1H, s), 10.32 (1H, s); m/z: (ES+), [M+H]+ = 503.3

{¾ _. 5rXMeth _j Jamino) _: 6-(3-methylimidazo[4 ₅ 5-cJp _j ridin _: 7-yl)-3 _: [4-[(l _: methyl _: 4- piperidyl)oxy]anilino]pyrazine-2-carbpxamide

7 N Methanolic ammonia (1 mL, 7 mmol) was added to a suspension of methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[( l -methyl-4- piperidyl)oxy]anilino]pyrazine-2-carboxylate (60mg, 0.12 mmol) in MeOH (2 mL). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column, using a 19 mm x 250 mm, 5 micron, XSelect CSH C18 OBD column, using 8-12% MeCN-fhO as eluent and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- [(l- methyl-4-piperidyl)oxy]anilino]pyrazine-2-carboxamide (28 mg, 45%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.69 — 1.83 (2H, m), 1.94 - 2.05 (2H, m), 2.47 (3H, s), 2.63 - 2.77 (2H, m), 2.84 - 3.02 (5H, m), 4.02 (3H, s), 4.43 (1H, m), 6.93 - 7.03 (2H, m), 7.34 (1H, s), 7.69 - 7.73 (2H, m), 8.00 (1H, m), 8.15 (1H, s), 8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.36 (1H, s); m/r (ES+), [M+H]+ = 488.3 Example 165

3-r4-rri-(2-Hvdroxyacetvn-4-piperidyl1oxy1anilino1-5-(met hylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

{4).M9thy.l.3:I4:L[l.-(2-hydrgxyacetyl)-4.-piperidylJoxy] .anilingl _: 5-(methylamino)-6-(3- methyHmidazg£4 ₁ 5 _: c]pyridin-7 _: ylJpyrazine-2 _: carbgxylate

DMAP (2 mg, 0.02 mmol) was added to a solution of 2-hydroxyacetic acid (31 mg, 0.41 mmol), HATU (93 mg, 0.25 mmol), triethylamine (69 μL, 0.49 mmol) and methyl 6-(3- methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)-3-((4- (piperi din-4- yloxy)phenyl)amino)pyrazine-2-carboxylate (80 mg, 0.16 mmol) in DCM (20 mL). The resulting mixture was stirred at 25 °C for 2 hours. The reaction was washed three times with water (50 mL each). The organic layer was concentrated to afford methyl 3-[4-[[l-(2- hydroxyacetyl)-4-piperidyl]oxy]anilino]-5-(methylamino)-6-(3 -methylimidazo[4,5-c]pyridin- 7-yl)py ^raz i ⁿ e-2-carboxylate (0.080 g, 89%) as a yellow solid; 1H NMR (300 MHz, DMSO- d6) d 1.42 - 1.65 (2H, m), 1.90 - 2.00 (2H, m), 2.90 (3H, d), 3.50 - 3.66 (1H, m), 3.83 (3H, s), 3.85 - 3.92 (1H, s), 4.02 (3H, s), 4.11 (3H, s), 4.47 - 4.60 (2H, m), 5.76 (1H, s), 7.01 (2H, d), 7.72 (2H, d), 7.92 (1H, br q), 8.51 (1H, s), 8.55 (1H, s), 9.06 (1H, s), 10.29 (1H, s); m/r (ES+), [M+H]+ = 547.3 .(b).3 - [4.-1 [1.-(2-Hy drpxy acety l) _: 4.-pip.eri dy 1J oxyjanil ino]. _: 5 -(methy 1 aminp)-6 _: (3 - JI ¹ ethyj.i m j daz.014 _^ 5 _: _c]pyri din- 7 _: yjjpy raz.i.ne-2 _: _carb ox am ide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to a suspension of methyl 3-[4-[[l - (2-hydroxyacetyl)-4-piperidyl]oxy]anilino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (70 mg, 0.13 mmol) in MeOH (5 mL). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC Column, using a 19 mm x 250 mm, 5 micron, XSelect CSH C18 OBD column, using 23-33% MeCN-FbO as eluent and 0.1% formic acid as modifier, to afford 3-[4-[[l-(2-hydroxyacetyl)-4-piperidyl]oxy]anilino]-5-(methy lamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (28 mg, 41%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.46-1.68 (2H, m), 1.86-2.03 (2H, m), 2.94 (3H, d), 3.14- 3.22 (2H, m), 3.52-3.64 (1H, m), 3.82 - 3.93 (1H, m), 4.04 (3H, s), 4.11 (2H, s), 4.47 - 4.77 (2H, m), 7.00 (2H, d), 7.36 (1H, s), 7.71 (2H, d), 7.76 (1H, s), 7.98 (1H, br q), 8.61 (1H, s), 8.78 (1H, s), 9.10 (1H, s), 11.37 (1H, s); m/z\ (ES+), [M+H]+ = 532.3

Example 166

5-Methoxy-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r4-r(T -methyl-4- piperidvDoxylanilinolpyrazine-2-carboxamide

(aJ.MethyJ. J.:I4:£(j -tert_-butoxy_carb_o_nyJ-4_-p_iperi_dyJJoxy].anniripl-6-chJp ro-5-m_et_hpxy- pyrazine-2 _: carbpxylate

DIPEA (410 μL, 2.5 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5-methoxy- pyrazine-2-carboxylate (500 mg, 2.27 mmol) and tert-butyl 4-(4-aminophenoxy)piperidine-l- carboxylate (696 mg, 2.38 mmol) in DMF (1.9 mL). The resulting solution was stirred at 100 °C for 1 hour. It was then allowed to cool to room temperature and diluted with EtOAc (5 mL) and water (5 mL). The layers were separated and the aqueous layer was extracted three times with EtOAc (5 mL each). The combined organic layers were washed twice with brine (5 mL each), dried over sodium sulfate, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% MeOH-DCM as eluent, to afford methyl 3-[4-[(l-tert- butoxycarbonyl-4-piperidyl)oxy]anilino]-6-chloro-5-methoxy-p yrazine-2-carboxylate (200 mg, 18% yield) as a brown solid, m/z: (ES-), [M-H]- = 491.1. {¾ _. Methyl _. 3_-[4 _r {(l-teit-butQxycarbpnyl _: _4-piperidyl)oxyJanilinoJ:5_-methoxy-6 _: (3- .91 ethyJi rnjdazo^ _^ S _: _c]pyri din- 7 _: yjjpy razjn e-2 _: carb pxyjate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (500 mg, 2.36 mmol), Bis(pinacolato)diboron (1.50 g, 5.89 mmol), cataCXium A (85 mg, 0.24 mmol), cataCXium A Pd G3 (172 mg, 0.240 mmol), and potassium acetate (694 mg, 7.07 mmol) were added to a vial. DMF (11.8 mL) was then added. The resulting mixture was sparged with nitrogen for 5 minutes, then and stirred at 80 °C for 16 hours. It was then cooled to room temperature and set aside.

A mixture of cesium fluoride (185 mg, 1.22 mmol), Pd(dppf)Ch DCM adduct (30 mg, 0.04 mmol), and methyl 3-[4-[(l-tert-butoxycarbonyl-4-piperidyl)oxy]anilino]-6-chlo ro-5- m ethoxy -pyrazine-2-carboxylate (200 mg, 0.41 mmol) was combined in a vial, which was evacuated and backfilled three times with nitrogen. A portion (2.03 mL) of the borylation mixture was added via syringe. The resulting suspension was stirred at 100 °C for 3 hours.

The reaction was then allowed to cool to room temperature and diluted with LbO (30 mL) and DCM (30 mL). The layers were separated and the aqueous layer was extracted three times with DCM (30 mL each). The organic layers were combined, dried over NaiSCL, and concentrated. The resulting residue was then loaded onto celite and purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[(l-tert- butoxycarbonyl-4-piperidyl)oxy]anilino]-5-methoxy-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.112 g, 47%) as a brown solid; 1HNMR (500MHz, DMSO-d6) d 1.40 (9H, s), 1.46 - 1.57 (2H, m), 1.82 - 1.97 (2H, m), 3.09 - 3.22 (2H, m), 3.61 - 3.72 (2H, m), 3.85 (3H, s), 3.86 (3H, s), 3.97 (3H, s), 4.41 - 4.62 (1H, m), 7.01 (2H, d), 7.64 (2H, d), 8.36 (1H, s), 8.36 (1H, s), 9.00 (1H, s), 10.20 (1H, s); m/z: (ES-), [M-H]- = 588.2 £cJ.M_ethyJ__5-methoxy-6-(_3_-methy]j_midazp[4,_5_-c]py_rid in _: 7-ylJ-3:£4:_(4- pipexidy!pxyJani]i_noJpyrazine-2:carboxyJa.te

2,2,2-Trifluoroacetic acid (440 μL, 5.70 mmol) was added to a solution of methyl 3-[4-[(l - tert-butoxy carbonyl -4-piperidyl)oxy]anilino]-5-methoxy-6-(3-methylimidazo[4,5-c ]pyridin-7- yl)pyrazine-2-carboxylate (112 mg, 0.19 mmol) in DCM (0.51 mL). The resulting solution was stirred at room temperature for 15 minutes. The reaction was then concentrated to yield methyl 5-methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(4- piperidyloxy)anilino]pyrazine-2-carboxylate (0.089 g, 96%) as a yellow gum. The product was used without further purification; m/z: (ES+), [M+H]+ = 490.3 {¾ _. 5rMethpxy-6-(3-methyhmidazo^4J-c] _. pyridin-7-yl)-3-[4-[(l _: methyl-4- piperidyl)oxy]anilinp]pyrazine-2-carbpxamide Sodium triacetoxyborohydride (58 mg, 0.28 mmol) was added portionwise to a stirred solution of methyl 5-methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(4- piperidyloxy)anilino]pyrazine-2-carboxylate (89 mg, 0.18 mmol) and 37 wt% aqueous formaldehyde (21 μL, 0.28 mmol) in DCM (1.82 mL) under nitrogen. The resulting solution was stirred at room temperature for 1 hour. The reaction was then diluted with saturated aqueous sodium bicarbonate (5 mL) and DCM (5 mL). The layers were separated, and the aqueous layer was extracted twice with DCM (5 mL each). The combined organic layers were dried over sodium sulfate and concentrated. The resulting residue was treated with 7 N methanolic ammonia (2.0 mL, 14 mmol). The resulting mixture was stirred at 100 °C for 2 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 25-50% MeCN-FbO as eluent, and 0.2% NLLOH as modifier, to afford 5- methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l-meth yl-4- piperidyl)oxy]anilino]pyrazine-2-carboxamide (14 mg, 16%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) d 1.36 - 1.50 (1H, m), 1.54 - 1.68 (1H, m), 1.83 - 1.97 (2H, m), 2.10 - 2.20 (3H, m), 2.53 - 2.65 (2H, m), 2.86 - 2.99 (1H, m), 3.92 (3H, s), 3.97 (3H, s), 4.25 - 4.37 (1H, m), 6.91 - 7.02 (2H, m), 7.56 - 7.65 (2H, m), 7.68 (1H, br s), 7.95 (1H, br s), 8.39 (1H, s),

8.61 (1H, s), 8.97 (1H, s), 11.24 (1H, br s); m/z: (ES+), [M+H]+ = 489.2

Example 167 5-Cvclopropyl-6-(3-methylimidazc>r4.5-c1pyridin-7-vD-3-r4 -rn -methyl-4- piperidvDoxylanilinolpyrazine-2-carboxamide {aJ.M.ethyl. J.:I4:£(j__4ert-butoxy_carb_o_nyJ-4_-p_i_p_eri_dyJJoxy].ann inpl-6-c_hl_oro-5-cy_cl_opropyJ_ _: Pyxa?jne-2-c_arboxylate

Sodium nitrite (71.0 mg, 1.03 mmol) was added to a solution of methyl 3-amino-6-chloro-5- cyclopropyl-pyrazine-2-carboxylate (223 mg, 0.980 mmol) in HF-pyridine (3.0 mL, 87 mmol) at 0 C. The reaction was stirred at 25 C for 30 minutes. Additional sodium nitrite (20 mg, 0.29 mmol) was added in two portions over two hours. The reaction was then diluted with DCM (5 mL) and quenched with water (10 mL). The layers were separated and the aqueous layer was extracted twice with DCM (10 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated. The resulting residue was dissolved in DMF (3 mL). Tert-butyl 4-(4-aminophenoxy)piperidine-l-carboxylate (0.301 g, 1.03 mmol) and DIPEA (0.200 mL, 1.15 mmol) were sequentially added. The resulting mixture was stirred at 100 C for 2 hours. The reaction was then allowed to cool to room temperature, diluted with EtOAc (15 mL), and quenched with water (50 mL). The layers were separated and the aqueous layer was extracted twice with EtOAc (10 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-hexanes as eluent, to afford methyl 3-[4- [(l-tert-butoxycarbonyl-4-piperidyl)oxy]anilino]-6-chloro-5- cyclopropyl-pyrazine-2- carboxylate (0.247 g, 50%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 1.02 (2H, dt), 1.13 - 1.22 (2H, m), 1.40 (9H, s), 1.44 - 1.57 (2H, m), 1.84 - 1.95 (2H, m), 2.39 - 2.44 (1H, m), 3.15 (2H, br d), 3.58 - 3.73 (2H, m), 3.89 (3H, s), 4.45 - 4.56 (1H, m), 6.96 (2H, d), 7.42 (2H, d), 9.77 (1H, s); m/r. (ES+), [M+H]+ = 503.3

{b).Methyl.3_-[4-[(_l-teit-butoxycarbonyl _: _4-pipendyl)pxyJanilinpJ _: 5_-cyclpprppyl-6-(3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (156 mg, 0.740 mmol), bis(pinacolato)diboron (468 mg, 1.84 mmol), cataCXium A Pd G3 (54 mg, 0.070 mmol), cataCXium A (26 mg,

0.070 mmol), and potassium acetate (217 mg, 2.21 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (3.7 mL) was added and the reaction was stirred at 80 C for 24 hours. The reaction was then allowed to cool to room temperature and set aside.

Separately, methyl 3-[4-[(l-tert-butoxycarbonyl-4-piperidyl)oxy]anilino]-6-chlo ro-5- cyclopropyl-pyrazine-2-carboxylate (247 mg, 0.490 mmol), Pd(dppf)C12*dichloromethane adduct (40 mg, 0.05 mmol), and cesium fluoride (224 mg, 1.47 mmol) were combined in a scintillation vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added by syringe. The resulting mixture was stirred at 100 C for 2 hours. The reaction mixture was then loaded direclty onto celite and purified by silica gel chromatography, using 0-7% MeOH-DCM as eluent and 0-0.7% ammonia as modifier, to afford methyl 3-[4-[(l-tert-butoxycarbonyl-4-piperidyl)oxy]anilino]-5-cycl opropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.156 g, 53%) as a dark yellow residue; 1HNMR (500 MHz, dichloromethane-d20.87 - 0.94 (2H, m), 1.15 - 1.18 (2H, m), 1.45 (9H, s), 1.72 (2H, dtd), 1.86 - 1.98 (3H, m), 3.20 - 3.33 (2H, m), 3.68 - 3.78 (2H, m),

3.94 (3H, s), 3.96 (3H, s), 4.43 (1H, td), 6.93 (2H, br d), 7.56 (2H, br d), 8.01 (1H, s), 8.53 (1H, br s), 8.91 (1H, br s), 10.07 (1H, s). m/z\ (ES+), [M+H]+ = 599.8 {c) Me i5-cycl propyl _. -6 _:. (3 _: methylimidazo[ _. 5 _: c]pyridin-7 _: yl) _: 3 _. -[4-[(I-methyl _. -4 _: piperidyl)pxy]anilinp]pyrazine-2-carbpxylate

TFA (0.5 mL, 6.49 mmol) was added to a solution of methyl 3-[4-[(l-tert-butoxycarbonyl-4- piperidyl)oxy]anilino]-5-cyclopropyl-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxylate (156 mg, 0.26 mmol) in DCM (1.5 mL). The resulting solution was stirred at 25 C for 90 minutes. The reaction was then concentrated. The resulting dark yellow solid was dissolved in DCM (2 mL). 37 wt% aqueous formaldehyde (0.03 mL, 0.40 mmol) and sodium triacetoxyhydroborate (83 mg, 0.39 mmol) were sequentially added. The resulting mixture was stirred at 25 C for 30 minutes. Additional 37 wt% aqueous formaldehyde (0.100 mL, 1.20 mmol) was added and the reaction was stirred at 25 C for 30 minutes. Additional sodium triacetoxyborohydride (180 mg, 0.85 mmol) was added and the reaction was stirred at 25 C for 30 minutes. Additional sodium triacetoxyborohydride (100 mg, 0.47 mmol) was added and the reaction was stirred at 25 C for 15 minutes. The reaction was quenched with saturated aqueous sodium bicarbonate (15 mL) and extracted three times with DCM (10 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting yellow residue was purified by silica gel chromatography, using 0-10% MeOH- DCM as eluent and 0-1% ammonia as modifier, to afford methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l-methyl-4-piperidy l)oxy]anilino]pyrazine-2- carboxylate (0.088 g, 66%) as a yellow solid; 1HNMR (500 MHz, DMSO-d6) 0.83 - 0.95 (2H, m), 0.97 - 1.06 (2H, m), 1.57 - 1.76 (2H, m), 1.83 (1H, td), 1.89 - 2.01 (2H, m), 2.17 - 2.39 (5H, m), 2.65 - 2.84 (2H, m), 3.87 (3H, s), 3.99 (3H, s), 4.37 (1H, br s), 6.97 (2H, d), 7.53 (2H, d), 8.39 (1H, s), 8.42 (1H, s), 9.05 (1H, s), 9.91 (1H, s); m/z: (ES+), [M+H]+

514.3

{¾ _. 5rCycloprgpyl-6-(3 _: methylimidazg[4 _L 5 _: c]pyridin-7 _: ylJ-3-_[4_-[Q-methyl-4- piperidyl)oxy]anilinp]pyrazine-2-carbpxamide 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l-methyl-4-piperidy l)oxy]anilino]pyrazine-2- carboxylate (88 mg, 0.17 mmol). The resulting yellow solution was stirred at 100 C for 1 h in a Biotage microwave reactor. The reaction was allowed to cool to room temperature. The resulting yellow suspension was filtered and rinsed sparingly with MeOH to afford 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-[(l -methyl-4- piperidyl)oxy]anilino]pyrazine-2-carboxamide (48 mg, 56%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 0.79 - 0.96 (2H, m), 0.99 - 1.09 (2H, m), 1.54 - 1.70 (2H, m), 1.85 - 1.97 (3H, m), 2.06 - 2.22 (5H, m), 2.56 - 2.66 (2H, m), 3.99 (3H, s), 4.30 (1H, td), 6.94 (2H, d), 7.53 (2H, d), 7.79 (1H, br d), 8.05 (1H, br s), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 11.08 (1H, s); m/z: (ES+), [M+H]+ = 499.4

Example 168

3-G3.5-Difluoro-4-rn -methyl -4-piperidvnoxylanilinol-5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

(a) tert-Buty!J-Xfl^romo-^^-difluprp^phenoxyJpiperidinerl-carbox ylate 4-Bromo-2,6-difluoro-phenol (1.00 g, 4.78 mmol) and potassium carbonate (1.98 g, 14.4 mmol) were added to tert-butyl 4-methylsulfonyloxypiperidine-l-carboxylate (2.01 g, 7.18 mmol) in DMSO (20 mL). The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then diluted with EtOAc (300 mL) and washed with brine three times (300 mL each). The organic layer was dried over MgSCL, filtered, and concentrated. The resulting residue was purified by C18 reverse phase chromatography, using 5-100% MeCN-EhO as eluent and 0.1% formic acid as modifier to afford tert-butyl 4-(4-bromo-2,6-difluoro- phenoxy)piperidine-l-carboxylate (0.500 g, 27%) as a yellow oil; 1H NMR (400 MHz, DMSO-d6) d 1.41 (9H, s), 1.56 (2H, dtd), 1.86 (2H, ddd), 3.14 (2H, t), 3.65 (2H, ddd), 4.31 (1H, tt), 7.48 - 7.59 (2H, m); m/z: (ES+), [M-C ₅ H ₉ 0 ₂ +H]+ = 291.9 {¾.Meΐ¾1.3_-[4-[^-ΐ6ΐ1-1)uΐrcg.V.4Lrh^ _: 4-^r6p^^rcg] _: 3 _; 5-V1ίAmoco-3hί1ίhr]. _: 5- {inethylaminpJ-6-X3-methylimidazp[4,5-cJpyridin _: 7-yl)p_yrazine _: 2-carbpxylate tert-Butyl 4-(4-bromo-2,6-difluoro-phenoxy)piperidine-l-carboxylate (282 mg, 0.720 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (150 mg, 0.48 mmol), cesium carbonate (468 mg, 1.44 mmol), and BrettPhos Pd G3 (65 mg, 0.070 mmol) in 1,4-dioxane (15 mL) under nitrogen.

The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-30% MeOH-DCM as eluent, to afford methyl 3-[4-[(l-tert-butoxycarbonyl-4-piperidyl)oxy]-3,5-difluoro- anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.120 g, 40%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.41 (9H, s), 1.54 - 1.63 (2H, m), 1.80 - 1.97 (2H, m), 2.93 (3H, d), 3.08 - 3.19 (2H, m), 3.63 - 3.73 (2H, m), 3.84 (3H, s), 4.01 (3H, s), 4.22 (1H, dt), 7.73 (2H, d), 8.05 (1H, br q), 8.50 (1H, s), 8.53 (1H, s), 9.05 (1H, s), 10.48 (1H, s); m/z: (ES+), [M+H]+ = 625.3 .(c) Methyl .3 _: _[3,5 :difluprp _: 4-X4-pippri dy lpxyjanilinp] - 5 _: (methyl aminp)-6-(3 - methyhmidazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

4 M HC1 in dioxane (3.0 mL, 12 mmol) was added to methyl 3-[4-[(l-tert-butoxycarbonyl-4- piperidyl)oxy]-3,5-difluoro-anilino]-5-(methylamino)-6-(3-me thylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (120 mg, 0.19 mmol) in MeOH (20 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated to afford methyl 3-[3,5-difluoro-4-(4-piperidyloxy)anilino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 99% yield) as a yellow residue, m/z: (ES+), [M+H]+ = 525.4

_. (¾ _. Methyl _. 3_-)3,5_-difluprp-4-[(l _: methyl _: 4_-piperidyl)pxy)anilinp] _. :5-(methylaminp)-6 _: (3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

Paraformaldehyde (57.2 mg, 1.91 mmol) was added to a mixture of methyl 3-[3,5-difluoro-4- (4-piperidyloxy)anilino]-5-(methylamino)-6-(3-methylimidazo[ 4,5-c]pyridin-7-yl)pyrazine-2- carboxylate (100 mg, 0.19 mmol) and sodium triacetoxyborohydride (162 mg, 0.760 mmol) in THF (10 mL). The resulting mixture was stirred at room temperature for 16 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM (10 mL) and washed twice with saturated sodium bicarbonate (10 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford and evaporated to afford methyl 3- [3,5-difluoro-4-[(l-methyl-4-piperidyl)oxy]anilino]-5-(methy lamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 1.65 - 1.75 (2H, m), 1.85 - 1.90 (2H, m), 2.08 - 2.12 (3H, m), 2.16 (3H, s), 2.61 - 2.65 (2H, m), 2.92 (3H, d), 3.83 (3H, s), 4.01 (3H, s), 7.72 (2H, d), 8.04 (1H, br q), 8.50 (1H, s), 8.53 (1H, s), 9.05 (1H, s), 10.48 (1H, s)

{ej _. SrD^^Difluprp^fl-tQ-methyM^piperidy^oxyJanilinoJ-S^^me thylamino^e-Q- methyhmidazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[3,5-difluoro-4-[(l- methyl-4-piperidyl)oxy]anilino]-5-(methylamino)-6-(3-methyli midazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (60 mg, 0.11 mmol). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 x 150 mm XBridge Prep OBD C18 column, 20-50% MeCN-H ₂ 0 as eluent, and 0.1% NH4HCO3 as modifier, to afford 3-[3,5-difluoro-4-[(l- methyl-4-piperidyl)oxy]anilino]-5-(methylamino)-6-(3-methyli midazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (57 mg, 98%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.60 - 1.77 (2H, m), 1.79 - 1.94 (2H, m), 2.04 - 2.14 (2H, m), 2.16 (3H, s), 2.60 - 2.72 (2H, m), 2.96 (3H, d), 3.97 - 4.10 (4H, m), 7.45 (1H, s), 7.60 - 7.69 (2H, m), 7.81 (1H, d), 8.08 (1H, br q), 8.53 (1H, s), 8.73 (1H, s), 9.04 (1H, s), 11.68 (1H, s); m/z: (ES+), [M+H]+ = 524.2

Example 169

3-r4-rn-Isopropyl-4-piperidvnoxylanilinol-5-(methylamino) -6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide formate salt

5-(Methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3- [4-(4- piperidyloxy)anilino]pyrazine-2-carboxamide (120 mg, 0.25 mmol) was added to a mixture of sodium triacetoxyborohydride (537 mg, 2.53 mmol), acetone (56 μL, 0.76 mmol), and titanium isopropoxide (72 mg, 0.25 mmol) in DCM (10 mL). The resulting mixture was stirred at room temperature for 1 hour. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 x 150 mm Xselect CSH OBD column, 20-30% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[(l- isopropyl-4-piperidyl)oxy]anilino]-5-(methylamino)-6-(3-meth ylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide formate salt (19 mg, 13%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.00 (6H, d), 1.54 - 1.65 (2H, m), 1.89 - 2.00 (2H, m), 2.32 - 2.31 - 2.44 (2H, m), 2.70 - 2.81 (3H, m), 2.93 (3H, d), 4.01 (3H, s), 4.25 - 4.33 (1H, m), 6.90 - 6.98 (2H, m), 7.32 (1H, s), 7.63 - 7.72 (2H, m), 7.72 (1H, s), 8.00 (1H, br q), 8.19 (1H, s), 8.52 (1H, s), 8.73 (1H, s), 9.01 (1H, s), 11.33 (1H, s); m/z: (ES+), [M+H]+ = 516.4

Example 170

3-r4-rr(2S.4R)-4-Hydroxy- l -rn ethyl -pyrrol idin-2-vHrnethoxy1anilino1-5-methyl-6-ri - methylbenzimidazol-4-vnpyrazine-2-carboxamide {aXM?jfcylX2S _^ 4¾ _: 4-[_tert:buj^XdiphenylJsnylJoxy-l-methyl-j)yn;oHdinye- 2 _: c^bpxylate tert-Butyl-chloro-diphenyl-silane (1.27 mL, 4.90 mmol) was added to a solution of methyl (2S,4R)-4-hydroxy-l-methyl-pyrrolidine-2-carboxylate (650 mg, 4.08 mmol) and imidazole (417 mg, 6.12 mmol) in DMF (8 mL). The resulting mixture was stirred at 25 C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-hexanes as eluent, to afford methyl (2S,4R)-4-[tert- butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidine-2-carboxylate (1.34 g, 83%) as a colorless oil. m/r (ES+), [M+H]+ 398.3

_. (bJX(2S _J 4R)-4 _r £tert-Butyl(diphenyl)silyJ]oxy-l _T rnethyJ _T pyrrolidin _T 2-y'J]methanoJ Lithium aluminum hydride (0.192 g, 5.06 mmol) was added to a solution of methyl (2S,4R)- 4-[tert-butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidine-2-carb oxylate (1.34 g, 3.37 mmol) in THF (15 mL) at 0 °C. The resulting mixture was stirred at 25 C overnight. The reaction was then diluted with ether and cooled to 0 °C. Water (0.2 mL) was added dropwise. 15% aqueous sodium hydroxide (0.2 mL) was added dropwise. Additional water (0.6 mL) was added dropwise. The resulting mixture was stirred at 25 C for 15 minutes, then dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford [(2S,4R)-4-[tert- butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidin-2-yl]methanol (1.032 g, 83%) as a pale yellow oil. 1HNMR (500MHz, DMSO-d6) 0.99 (9H, s), 1.64 - 1.74 (1H, m), 1.76 - 1.85 (1H, m), 2.18 - 2.31 (4H, m), 2.51 - 2.58 (1H, m), 3.02 (1H, dd), 3.12 - 3.22 (1H, m), 3.31 - 3.36 (1H, m), 4.16 - 4.28 (1H, m), 4.34 (1H, br s), 7.36 - 7.50 (6H, m), 7.55 - 7.61 (4H, m); m/r (ES+), [M+H]+ = 370.6

(cJdXS^RJ-X-Xtert-ButyJdiXhenyJsilyJJpxyj-j-methyLX-XAnjt rophenoxyjmethylJpyrrolidi.ne DIAL ⁾ (253 μL, 1.30 mmol) was added to a mixture of 4-nitrophenol (166 mg, 1.19 mmol), [(2S,4R)-4-[tert-butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidi n-2-yl]methanol (400 mg, 1.08 mmol), and triphenylphosphine (341 mg, 1.30 mmol) in toluene (5 mL). The resulting mixture was stirred at 25 C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-hexanes as eluent, to afford (2S,4R)-4-((tert-butyldiphenylsilyl)oxy)-l-methyl-2-((4- nitrophenoxy)methyl)pyrrolidine (0.717 g, 135%) as a yellow gum. This material contained residual triphenylphosphine oxide; it was carried forward to the next step without further purification. m/r. (ES+), [M+H]+ = 491.3

(dl.iXR^Sj-l^Methyl-^^rnjtrpphenoxyJmethylJpyrrqlidjn-j^o J 1 M TBAF in THF (1.19 mL, 1.19 mmol) was added to a solution of (2S,4R)-4-((tert- butyldiphenylsilyl)oxy)-l-methyl-2-((4-nitrophenoxy)methyl)p yrrolidine (531 mg, 1.08 mmol) in THF (3 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 7% MeOH-DCM, to afford (3R, 5 S)-l -methyl-5 -[(4- nitrophenoxy)methyl]pyrrolidin-3-ol (0.115 g, 42%) as a white solid; 1H NMR (500 MHz, DMSO-d6) d 1H NMR (500MHz, DMSO-d6) 1.57 (1H, ddd), 1.85 - 1.94 (1H, m), 1.99 (1H, br dd), 2.16 (3H, s), 2.31 - 2.40 (1H, m), 2.55 - 2.65 (2H, m), 3.83 (1H, tq), 4.71 (1H, d), 4.83 - 4.92 (1H, m), 7.06 - 7.16 (2H, m), 8.11 - 8.22 (2H, m). m/z: (ES+), [M+H]+ 253.2 {9)X3R ₃ 5.¾-5-[(4 _: Aminophenoxy)methylJ-ri. _: methyl _: pyiTqlidin _: 3-ol A mixture of (3R,5S)-l-methyl-5-[(4-nitrophenoxy)methyl]pyrrolidin-3-ol (50 mg, 0.20 mmol) and 10 wt% palladium on carbon (21.09 mg, 0.02 mmol) in MeOH (5 mL) was stirred under a hydrogen atmosphere at 25 C for 2 hours. The reaction was then filtered through celite and concentrated. The resulting residue was used directly in the next step without further purification, assuming 100% yield of (3R,5S)-5-[(4-aminophenoxy)methyl]-l-methyl- pyrroli din-3 -ol. m/z: (ES+), [M+H]+ = 223.1

{O.M.Qthyl.6-chlgro-3-[4 _: ^[( _^ 2S _I 4R)-4 _: hy_droxy-l-m_ethyl-pyrroli_din-2 _: y_lJm_ethpxyJanil_inoJ _: 5_- methyLpyrazine-2 _: carbpxylate

DIPEA (104 μL, 0.590 mmol) was added to a mixture of methyl 6-chloro-3-fluoro-5-methyl- pyrazine-2-carboxylate (41 mg, 0.20 mmol) and (3R,5S)-5-[(4-aminophenoxy)methyl]-l- methyl-pyrrolidin-3-ol (44 mg, 0.20 mmol) in MeCN (2 mL). The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[4-[[(2S,4R)-4-hydroxy-l-methyl- pyrroli din-2 -yl]methoxy]anilino]-5-methyl-pyrazine-2-carboxylate (0.046 g, 57%) as a light orange solid, m/z: (ES+), [M+H]+ = 407.2 ig).M9thyl_3_-[4-[[{2S,4R)_-4 _: hy_droxy-ri-methy_l-py_iTolidin _: 2_-y_l]methpxy.]ani_hno]-5-methyl-6-

{l:lpethylbenzimidazol _r 4-yl) _. pyrazine-2-carboxylate

A mixture of methyl 6-chloro-3-[4-[[(2S,4R)-4-hydroxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-methyl-pyrazine-2-carboxylate (45 mg, 0.11 mmol), l-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzimidazole (63 mg, 50 wt%, 0.12 mmol), PdCb(dppf)-DCM adduct (9 mg, 0.01 mmol) and cesium fluoride (34 mg, 0.22 mmol) was evacuated and backfilled three times with nitrogen. MeOH (2 mL) was added and the resulting mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[[(2S,4R)-4-hydroxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-m ethyl -6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxylate (0.037 g, 67%) as a light yellow solid. m/z\ (ES+), [M+H]+ 503.3

_. (h) _. 3-[4 _. -X[ _. (2S,4R)-4 _: Hydroxy-l _. -niethyl-pyrrolidin-2 _: ylJmethoxyJanilino]:5-methyl-6 _: (l- methyJbenzimidazgl-4 _: yl)pyrazine-2-carbpxamide 7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[4-[[(2S,4R)-4-hydroxy-

1-methyl-pyrroli din-2 -yl]methoxy]anilino]-5-methyl-6-(l -methylbenzimidazol-4-yl)pyrazine-

2-carboxylate (37 mg, 0.07 mmol). The resulting mixture was stirred at 50 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 3-[4-[[(2S,4R)-4-hydroxy-l- methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6-(l-methyl benzimidazol-4-yl)pyrazine-2- carboxamide (32 mg, 89%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d 1.83 (2H, br s), 2.05 - 2.25 (1H, m), 2.37 (6H, s), 2.75 - 2.93 (1H, m), 3.23 (1H, br d), 3.79 - 3.93 (4H, m), 3.93 - 4.07 (1H, m), 4.09 - 4.27 (1H, m), 4.69 - 4.91 (1H, m), 6.96 (2H, br d), 7.41 (2H, d), 7.58 - 7.74 (3H, m), 7.84 (1H, br s), 8.05 (1H, br s), 8.24 (1H, s), 11.06 (1H, s); m/z\ (ES+), [M+H]+ 488.4

Example 171

3-r4-rr(2R.4S)-4-Hvdroxy-l-methyl-pyrrolidin-2-yllmethoxy lanilinol-5-methyl-6-n- methylbenzimidazol-4-vDpyrazine-2-carboxamide

02-methyl X2¾4.¾:4-[tert-butylXdiphenylJsilylloxyp.yn;olidine-L2 _: dj carboxy l ate tert-Butyl-chloro-diphenyl-silane (1.38 mL, 5.30 mmol) was added to a solution of 01-tert- butyl 02-methyl (2R,4S)-4-hydroxypyrrolidine-l,2-dicarboxylate (1.00 g, 4.08 mmol), and imidazole (0.555 g, 8.15 mmol) in DMF (8 mL). The resulting mixture was stirred at 25 C for 1 hour. The reaction was then concentrated. The residue was purified by silica gel chromatography, using 0-30% EtOAc in hexanes, to afford Ol-tert-butyl 02-methyl (2R,4S)- 4-[tert-butyl(diphenyl)silyl]oxypyrrolidine-l,2-dicarboxylat e (1.97 g, 100%) as a colorless oil. in r: (ES+), [M-C ₅ H ₉ 0 ₂ +H]+ = 384.3

(b ) _. [(2 R,4S)-4 _r Xtert-Butyl (diphenyl ) si lyJJ oxy- l _.T methyJ _T pyrrolidin _T 2-yJ]methanoJ Lithium aluminum hydride (0.464 g, 12.2 mmol) was added to a solution of Ol-tert-butyl 02- methyl (2R,4S)-4-[tert-butyl(diphenyl)silyl]oxypyrrolidine-l,2-dica rboxylate (1.97 g, 4.07 mmol) in THF (15 mL) at 0 °C. The resulting mixture was stirred at 25 C for 16 hours. The reaction mixture was diluted with ether and cooled to 0 °C. Water (0.5 mL) was added dropwise. 15% aqueous sodium hydroxide (0.5 mL) was added dropwise. Water (1.5 mL) was added. The resulting mixture was stirred at 25 C for 15 minutes. The resulting suspension was dried over magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford [(2R,4S)-4-[tert- butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidin-2-yl]methanol (0.681 g, 45% yield) as a pale yellow oil. m/z: (ES+), [M+H]+ = 370.3

(cJ^ert-Butyl-tQS^RJ-j-methyJ-ii^fl-nitrophenqxyJmethyJJp yrrpJjdin^j-yJJoxy-diphenyJ- silane

DIAL) (395 μL, 2.03 mmol) was added to a mixture of 4-nitrophenol (259 mg, 1.86 mmol), [(2R,4S)-4-[tert-butyl(diphenyl)silyl]oxy-l-methyl-pyrrolidi n-2-yl]methanol (625 mg, 1.69 mmol), and triphenylphosphine (532 mg, 2.03 mmol) in toluene (10 mL). The resulting mixture was stirred at 25 C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-hexanes as eluent, to afford tert-butyl-[(3S,5R)-l-methyl-5-[(4-nitrophenoxy)methyl]pyrro lidin-3-yl]oxy-diphenyl- silane (0.617 g, 74%) as a yellow gum. m/z: (ES+), [M+H]+ = 491.4 _. (dJ _. ( _. 3S,5R)-l _T Methyl-5-[(4 _: nitrophenpxy)rnethylJpyrrolidin-3 ₇ pJ

1 M TBAF in THF (1.38 mL, 1.38 mmol) was added to a solution of tert-butyl-[(3S,5R)-l- methyl-5-[(4-nitrophenoxy)methyl]pyrrolidin-3-yl]oxy-dipheny l-silane (617 mg, 1.26 mmol) in THF (5 mL) at 0 °C. The resulting mixture was stirred at 0 °C for 4 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0- 7% MeOH-DCM as eluent, to afford (3S,5R)-l-methyl-5-[(4- nitrophenoxy)methyl]pyrrolidin-3-ol (0.211 g, 67%) as a white solid; 1H NMR (500 MHz, DMSO-d6) 1.59 (1H, ddd), 1.85 - 1.96 (1H, m), 1.96 - 2.10 (1H, m), 2.18 (3H, s), 2.32 - 2.42 (1H, m), 2.57 - 2.68 (2H, m), 3.85 (1H, tq), 4.74 (1H, br d), 4.89 (1H, br s), 7.08 - 7.21 (2H, m), 8.14 - 8.26 (2H, m); m/r. (ES+), [M+H]+ = 253.1

{9)M9thyJ..6 _: chlprg-3-[4-[£(2R ₁ 4S) _: 4-hydxqxy-l _: methyJ. _: pyrrqlidin _: 2-yl]methoxy]anilino]-5 _: methyd:pyrazine-2 _: carbgxylate

A mixture of (3S,5R)-l-methyl-5-[(4-nitrophenoxy)methyl]pyrrolidin-3-ol (34 mg, 0.13 mmol) and 10 wt% palladium on carbon (14 mg, 0.010 mmol) in MeOH (5 mL) was stirred uner a hydrogen atmosphere at 25 C for 2 hours. The reaction was then filtered through celite and concentrated. The resulting residue was dissolved in MeCN (1 mL). Methyl 6-chloro-3- fluoro-5-methyl-pyrazine-2-carboxylate (28 mg, 0.13 mmol) and DIPEA (71 μL, 0.40 mmol) were added to the reaction mixture. The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[4-[[(2R,4S)-4-hydroxy-l-methyl-pyrrolidin-2-yl]m ethoxy]anilino]-5-methyl- pyrazine-2-carboxylate (0.020 g, 36%) as a light yellow solid, m/r (ES+), [M+H]+ = 407.2 {0.M.QthyL3-L4"II(2¾4S):4 _r hydroxy-l-methyEpyj[Tgli¾n _: 2-^J]methoxylanilingl-5 _: metihyl:6- {l.:lP.9thylbenzimidazol _r 4 _: yl).pyrazine-2-carboxylate

A mixture of methyl 6-chloro-3-[4-[[(2R,4S)-4-hydroxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-methyl-pyrazine-2-carboxylate (20 mg, 0.05 mmol), l-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzimidazole (28 mg, 0.050 mmol), PdCb(dppf)-DCM adduct (4.0 mg, 4.9 pmol), and cesium fluoride (15 mg, 0.10 mmol) was evacuated and backfilled three times with nitrogen. MeOH (1 mL) was added and the resulting mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[[(2R,4S)-4-hydroxy-l -methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6-( 1 - methylbenzimidazol-4-yl)pyrazine-2-carboxylate (0.022 g, 89%) as a light yellow solid, m/r (ES+), [M+H]+ = 503.3 fe) _. 3rI4rI[ _. (2R,4S)-4 _: Hydroxy-l _. -inethyl-pyrrolidin-2 _: ylJinethoxyJanilino]:5-methyl-6 _: (l- methyJbpnzimidazgl-4 _: yl)pyrazine-2-carbgxamide 7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[4-[[(2R,4S)-4-hydroxy-

1-methyl-pyrroli din-2 -yl]methoxy]anilino]-5-methyl-6-(l-methylbenzimidazol-4-yl)p yrazine-

2-carboxylate (22 mg, 0.040 mmol). The resulting suspension was stirred at 50 °C for 16 hours. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH- DCM as eluent, to afford 3-[4-[[(2R,4S)-4-hydroxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-m ethyl -6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxamide (15 mg, 68%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d 1.46 - 1.66 (1H, m), 1.76 - 1.91 (1H, m), 2.04 (1H, br dd), 2.16 (3H, s), 2.36 (3H, s), 2.37 - 2.42 (1H, m), 2.50 - 2.56 (2H, m), 3.80 - 3.94 (4H, m), 4.58 - 4.63 (1H, m), 4.64 (1H, d), 6.93 (2H, d), 7.39 (2H, d), 7.59 - 7.68 (3H, m), 7.82 (1H, br s), 8.03 (1H, br s), 8.22 (1H, s), 11.04 (1H, s); m/z\ (ES+), [M+H]+ = 488.4

Example 172

3-r4-rr(2R.4S)-4-Methoxy-l -methyl -pyrrol idin-2-yllmethoxylanilinol-5-m ethyl -6-G1 - methylbenzimidazol-4-vDpyrazine-2-carboxamide

{4)X2R,4¾:4-Methox _j. :l-methyl-2 _: [(4-nitrophenoxy)methylJpyrrolidine 60 wt% Sodium hydride in oil (9.1 mg, 0.23 mmol) was added to a solution of (3S,5R)-1- methyl-5-[(4-nitrophenoxy)methyl]pynOlidin-3-ol (48 mg, 0.19 mmol) and iodomethane (13 μL, 0.21 mmol) in THF (2 mL). The resulting mixture was stirred at 25 C for 16 hours. The reaction was then diluted with water and extracted with EtOAc. The organic layer was concentrated to afford (2R,4S)-4-methoxy-l-methyl-2-[(4-nitrophenoxy)methyl]pyrroli dine (0.047 g, 93%) as an oil. m/z\ (ES+), [M+H]+ = 267.2

{¾ _. Methyl _. 6-cMoro-3:[4-j^(2R,4SJ:4-methQxy-l:methyl:pyiTolidin _: 2-yl]methoxy]anilino]-5 _: m et hyj_:py razi_n e - 2 -ca_rb ox y.l ate

A mixture of (2R,4S)-4-methoxy-l-methyl-2-[(4-nitrophenoxy)methyl]pyrroli dine (47 mg, 0.18 mmol) and 10 wt% palladium on carbon (19 mg, 0.020 mmol) in MeOH (5 mL) was stirred under an atmosphere of hydrogen at 25 C for 2 hours. The reaction was then filtered through celite and concentrated. The resulting residue was dissolved in MeCN (2 mL).

Methyl 6-chloro-3-fluoro-5-methyl-pyrazine-2-carboxylate (36 mg, 0.18 mmol) and DIPEA (93 μL, 0.53 mmol) were sequentially added. The resulting mixture was stirred at 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[4-[[(2R,4S)-4-methoxy-l-methyl-pyrrolidin-2-yl]m ethoxy]anilino]- 5-methyl-pyrazine-2-carboxylate (0.040 g, 54%) as a light orange solid, m z: (ES+), [M+H]+ = 421.2

{9XMejfcyl.3:XC4rXCQ^4S)-4:methoxy _: l-methylpy.iTolidin-2-yl)methoxy)pheny.l)Mnino)-5- methyl:6-(l-methyl-lH-benzo[dJimidazQl-4 _: yl)pyrazine-2 _: carbpxylate A mixture of methyl 6-chloro-3-[4-[[(2R,4S)-4-methoxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-methyl-pyrazine-2-carboxylate (40 mg, 0.10 mmol), l-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzimidazole (54 mg, 50 wt%, 0.10 mmol), PdCb(dppf)-DCM adduct (7.8 mg, 9.5 pmol), and cesium fluoride (28.9 mg, 0.19 mmol) was evacuated and backfilled three times with nitrogen. MeOH (2 mL) was added and the reaction mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 120 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-((4- (((2R,4S)-4-methoxy-l-methylpyrrolidin-2-yl)methoxy)phenyl)a mino)-5-methyl-6-(l- methyl-lH-benzo[d]imidazol-4-yl)pyrazine-2-carboxylate (0.028 g, 57%) as a light yellow solid, m/z: (ES+), [M+H]+ = 517.3

£dJ.3_-[4_-b[_(2R,_4S)_-4 _: Mefhpxy_-l_ _: m_ethyJ_ _: py_rroj_i_di_n _: _2_-yJJ_methqxyJ_aniJj_nq]-5-m_ethyJ-6-(l_- methylbenzimidazgl-4:yl)pyrazine-2-carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-((4-(((2R,4S)-4- methoxy-l-methylpyrrolidin-2-yl)methoxy)phenyl)amino)-5-meth yl-6-(l-methyl-lH- benzo[d]imidazol-4-yl)pyrazine-2-carboxylate (28 mg, 0.050 mmol). The resulting suspension was stirred at 50 °C and stirred for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 3-[4-[[(2R,4S)-4-methoxy-l-methyl-pyrrolidin-2-yl]methoxy]an ilino]-5- methyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxamide (12 mg, 45%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d 1.63 - 1.77 (1H, m), 1.79 - 1.91 (1H, m), 2.18 (3H, s), 2.22 (1H, br dd), 2.36 (3H, s), 2.39 - 2.47 (2H, m), 2.51 - 2.58 (1H, m), 3.24

(3H, s), 3.56 (1H, tt), 3.88 (3H, s), 4.49 - 4.60 (1H, m), 6.83 - 7.01 (2H, m), 7.32 - 7.45 (2H, m), 7.59 - 7.69 (3H, m), 7.82 (1H, br s), 8.03 (1H, br s), 8.22 (1H, s), 11.05 (1H, s); m/z: (ES+), [M+H]+ 502.3

Example 173

3-r4-rii2S.4R)-4-Methoxy-l -methyl -pyrrol idin-2-yllmethoxylanilinol-5-m ethyl -6-P - methylbenzimidazol-4-vDpyrazine-2-carboxamide {aXQS _^ 4¾:4-Metihox^:X-methyl-2 _: £(4 _: nitrpphenoxyJmethyripyiTolidine

60 wt% Sodium hydride in oil (12 mg, 0.31 mmol) was added to a solution of (3R,5S)-1- methyl-5-((4-nitrophenoxy)methyl)pyrrolidin-3-ol (65 mg, 0.26 mmol) and iodomethane (18 μL, 0.28 mmol) in THF (2 mL). The resulting mixture was stirred at 25 C for 16 hours. The reaction was then quenched with water and extracted with EtOAc. The organic layer was concentrated to afford (2S,4R)-4-methoxy-l-methyl-2-[(4-nitrophenoxy)methyl]pyrroli dine (0.064 g, 93 %) as a light amber oil. m/z: (ES+), [M+H]+ = 267.2

_. (bJ _. Methy! _.. 6-chJorQ-3:£4_j^^2S _^ 4R) _: 4-methpxy-l _: methyJ _: pynolidin-2-yl]methoxy]anilino]-5 _T methyj. _: pyrazine-2 _: carbpxylate

A mixture of (2S,4R)-4-methoxy-l-methyl-2-[(4-nitrophenoxy)methyl]pyrroli dine (64 mg, 0.24 mmol) and 10 wt% palladium on carbon (26 mg, 0.020 mmol) in MeOH (5 mL) was stirred under a hydrogen atmosphere at 25 C for 2 hours. The reaction was then filtered through celite and concentrated. The resulting residue was redissolved in MeCN (2 mL). Methyl 6-chloro-3-fluoro-5-methyl-pyrazine-2-carboxylate (49 mg, 0.24 mmol) and DIPEA (0.13 mL, 0.72 mmol) were sequentially added. The resulting mixture was stirred 120 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[4-[[(2S,4R)-4-methoxy-l-methyl-pyrrolidin-2-yl]m ethoxy]anilino]- 5-methyl-pyrazine-2-carboxylate (9.0 mg, 8.9%) as a light orange solid, m z: (ES+), [M+H]+ 421.2

{c)M9thyIJ _. :I4:^[(2S _i 4R)-4-methpxy-l _r methyl _: pyrrolidin-2-yQmethoxy] _. anilinp] _. :5-methyl-6- il:inethylbenzimjdazolr4-yl)pyrazine-2-cagrboxylate

A mixture of methyl 6-chloro-3-[4-[[(2S,4R)-4-methoxy-l-methyl-pyrrolidin-2- yl]methoxy]anilino]-5-m ethyl -pyrazine-2-carboxylate (9.0 mg, 0.020 mmol), l-methyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzimidazole (12 mg, 50 wt%, 0.020 mmol), PdCb(dppf)-CH2Cl2adduct (1.7 mg, 2.1 pmol), and cesium fluoride (6.5 mg, 0.040 mmol) was evacuated and backfilled three times with nitrogen. MeOH (1 mL) was added and the reaction mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was subject to microwave at 120 °C for lh and evaporated. The residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[[(2S,4R)-4- methoxy-l-methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6 -(l-methylbenzimidazol-4- yl)pyrazine-2-carboxylate (5.0 mg, 45%) as a light yellow solid. m/z\ (ES+), [M+H]+ = 517.4 {dJ _. 3-[4 _r X[(2S,4R)-4 _: Methpxy-d _. :methyl:pyrrolidin:2 _r yl]methpxy]anilinp]-5-methyl-6-(l- methy _. lbenzimidazpl-4:yl)pyrazine-2-carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[4-[[(2S,4R)-4- methoxy-l-methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6 -(l-methylbenzimidazol-4- yl)pyrazine-2-carboxylate (5.0 mg, 9.7 gmol). The resulting suspension was stirred at 50 C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 3-[4-[[(2S,4R)-4- methoxy-l-methyl-pyrrolidin-2-yl]methoxy]anilino]-5-methyl-6 -(l-methylbenzimidazol-4- yl)pyrazine-2-carboxamide (4.3 mg, 89%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d 1.64 - 1.77 (1H, m), 1.79 - 1.91 (1H, m), 2.18 (3H, s), 2.20 - 2.27 (1H, m), 2.36 (3H, s), 2.39 - 2.45 (1H, m), 2.52 - 2.57 (1H, m), 3.24 (3H, s), 3.56 (1H, tt), 3.88 (3H, s), 4.51 - 4.59 (1H, m), 6.89 - 6.97 (2H, m), 7.34 - 7.42 (2H, m), 7.60 - 7.67 (3H, m), 7.82 (1H, br d), 8.04 (1H, br d), 8.22 (1H, s), 11.05 (1H, s); m/z\ (ES+), [M+H]+ = 502.3

Example 174

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 3-(4-methylpiperazin-l- vDanilinolpyrazine-2-carboxamide

(a) Methyl _. 3 _: £3 :{4 _: tert-butpxy carb ony lpiperazm- 1 ryl)anriinp] - 5 _: (methyl aminp)-6-(3 - JI ¹ ethyj _.i midazp^^^cjpyri din- 7 ryjjpy razi ne-^ _T carboxylate

Brettphos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), tert-butyl 4-(3-bromophenyl)piperazine-l-carboxylate (109 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[3-(4-tert-butoxycarbonylpiperazin-l-yl)anilino]-5-(methyl amino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.120 g, 66% yield) as a brown solid. 1H NMR (400 MHz, DMSO-i/6) d, 1.42 (9H, s), 2.93 (3H, d), 3.15 (4H, d), 3.46 (4H, s), 3.83 (3H, s), 4.01 (3H, s), 6.60 - 6.77 (1H, m), 7.12 - 7.29 (2H, m), 7.52 (1H, s), 7.90 (1H, br q), 8.51(2H, d), 9.04 (1H, s), 10.46 (1H, s). m/r. (ES+), [M+H]+ = 574.3 .(bJ _. Methy! _. 5 _. -(rnethyJamino)-6r _. (3:methy'limidazp[4 ₁ 5 _: c]pxridin-7ryI)r3-(3-piperazin- l- yJanjhpp)pyrazin_e _: _2-carboxyj_at_e

4 M HC1 in dioxane (10 mL, 40 mmol) was added to methyl 3-[3-(4-tert- butoxycarbonylpiperazin-l-yl)anilino]-5-(methylamino)-6-(3-m ethylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (120 mg, 0.21 mmol). The resulting mixture was stirred at 60 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent and 0.1% triethylamine as modifier, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(3- piperazin-l-ylanilino)pyrazine-2-carboxylate (0.090 g, 91% yield) as a brown solid. 1H NMR (400 MHz, DMSO-i/6) d 2.89 (3H, d), 3.21 (4H, s), 3.41 (4H, d), 3.82 (3H, s), 4.14 (3H, s), 6.70 - 6.79 (1H, m), 7.26 (1H, d), 7.45 - 7.55 (1H, m), 8.71 (1H, s), 9.04 (1H, s), 9.32 (2H, br s), 9.66 (1H, s), 10.51 (1H, s). m/r. (ES+), [M+H]+ = 474.1 £cJ.Methyl__5-(m_ethy]_ami_no)_-6 _: (_3-m_et_hyJ_im_i_dazoL4,_5-cJpy_ri^^n_-7:y!).:3-[3-(4 _: _methyl_pip_erazi_n_- lryi)anilino]pyrazine-2-carbpxylate

Sodium triacetoxyborohydride (121 mg, 0.57 mmol) was added to a solution of methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-(3-pi perazin-l-ylanilino)pyrazine- 2-carboxylate (90 mg, 0.19 mmol) and formaldehyde (132 μL, 1.90 mmol) in MeOH (10 mL). The resulting mixture was stirred at room temperature for 1 hour. The reaction was then concentrated. The resulting residue was redissolved in DCM and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[3-(4-methylpiperazin-l-yl)anilino]pyrazin e-2-carboxylate (0.090 g, 97% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-i/6) d 2.22 (3H, s), 2.45 (4H, t), 2.93 (3H, d), 3.17 (4H, t), 3.83 (3H, s), 4.01 (3H, s), 6.65 (1H, d), 7.07 - 7.27 (2H, m), 7.52 (1H, s), 7.89 (1H, br q), 8.51 (2H, d), 9.04 (1H, s), 10.45 (1H, s). m/r. (ES+), [M+H]+ = 488.3 {¾.5r£M9thy!aminp) _: 6-(3-methylimidazo[4 _: 5-cJpyridin _: 7-_yl)-3 _: £3-(4-methylpiperazin _: l- yI)ani!ipoJpyrazine-2-carbqxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[3-(4-methylpiperazin-l- yl)anilino]pyrazine-2- carboxylate (85 mg, 0.17 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 x 250 mm YMC-Actus Triart C18 column, 30-40% MeCN-water as eluent, and 10 mM ammonium bicarbonate and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[3- (4-methylpiperazin-l- yl)anilino]pyrazine-2-carboxamide (0.022 g, 27% yield) as a yellow solid. 1H NMR (DMSO- d6, 400 MHz) d 2.22 (3H, s), 2.45 (4H, t), 2.96 (3H, d), 3.16 (4H, t), 4.01 (3H, s), 6.61 (1H, dd), 7.04 (1H, dd), 7.16 (1H, t), 7.36 (1H, d), 7.57 (1H, t), 7.75 (1H, d), 7.93 (1H, br q), 8.52 (1H, s), 8.71 (1H, s), 9.02 (1H, s), 11.51 (1H, s). m/z (ES+), [M+H]+ = 473

Example 175

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 3-(T -methyl-4- piperidvDanilinolpyrazine-2-carboxamide formate salt

(a) Methyl _. 3 _: £3-( lrteit-butpxy _. c¾bonyl-4-piperidyl) _. agnilino] _. ·: 5 :_(methyl amino)-6-(3- PiethyJi nudazq^^cjpyri din- 7 ryjjpy razi ne-2:carboxylate

Brettphos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), tert-butyl 4-(3-bromophenyl)piperidine-l-carboxylate (109 mg, 0.32 mmol), and cesium carbonate (310 mg, 0.96 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[3-(l-tert-butoxycarbonyl-4-piperidyl)anilino]-5-(methylam ino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.130 g, 71% yield) as a brown solid. 1H NMR (400 MHz, DMSO-d6) d 1.19 - 1.26 (2H, m), 1.41 (9H, s), 1.50 - 1.54 (2H, m), 1.77 - 1.81 (1H, m), 2.73 (2H, s), 2.82 (2H, s), 2.92 (3H, d), 3.82 (3H, d), 4.01 (3H, s), 6.94 (1H, d), 7.28 (1H, t), 7.54 (1H, d), 7.86 (2H, d), 8.51 (2H, d), 9.05 (1H, s), 10.46 (1H, s). m/z: (ES+), [M+H]+ = 573.6 i¾.Methyl.5-(methyl^mo)-6 _: 0 _: methyHmidazp£4 ₁ 5 _: c]pyridin-7:yl):3-[3-(4- pipexidy!)an_iJ_inplp_y_razin_e _: _2-carboxy]_ate

4 M HC1 in dioxane (10 mL, 40.00 mmol) was added to methyl 3-[3-(l-tert-butoxycarbonyl- 4-piperidyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2- carboxylate (125 mg, 0.22 mmol). The resulting mixture was stirred at 60 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0.1% triethylamine as modifier, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[3- (4- piperidyl)anilino]pyrazine-2-carboxylate (0.090 g, 87% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.90 (3H, d), 3.39 (2H, s), 3.57 (6H, s), 3.82 (3H, s), 3.90 (1H, s),

4.14 (3H, s), 6.96 (1H, d), 7.34 (1H, t), 7.53 - 7.70 (3H, m), 8.72 (1H, s), 9.03 (1H, s), 9.65 (1H, s), 10.52 (1H, s). m/z: (ES+), [M+H]+ = 473.3 £cJ.Methyl__5-(m_ethy]_ami_no)_-6 _: (_3-m_et_hyJ_im_i_dazoL4,5_-cJpy_ri^^n_-7:y!).:3-[3-(l _ _: _methyl. ₇ 4- pjpexidyl)a_nninolp_y_razin_e _: 2-carboxy]ate

Sodium triacetoxyborohydride (121 mg, 0.570 mmol) was added to a solution of methyl 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[3-(4 -piperidyl)anilino]pyrazine-2- carboxylate (90 mg, 0.19 mmol) and 40% aqueous formaldehyde (131 μL, 1.90 mmol) in MeOH (10 mL). The resulting mixture was stirred at room temperature for 1 hour. The reaction was then concentrated. The resulting residue was redissolved in DCM and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[3-(l-methyl-4-piperidyl )anilino]pyrazine-2-carboxylate (0.085 g, 92% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.19 (3H, s), 2.93 (3H, d), 3.28-3.32 (8H, m), 3.82 (1H, d), 3.83 (3H, s), 4.01 (3H, s), 6.94 (1H, d), 7.28 (1H, t), 7.51 - 7.61 (1H, m), 7.77 (1H, t), 7.91 (1H, d), 8.51 (2H, d), 9.04 (1H, s), 10.44 (1H, s). m/z: (ES+), [M+H]+ = 487.4

{¾ _. 5r£MethjJamino):6-(3-methylimidazo[4,5-cJpyridin _: 7 ₇ yl)-3 _: [3-Q-methyl-4 _: pippridyl)anilinq] _. pyrazine-2-carboxamide formate salt

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[3-(l-methyl-4-piperidyl )anilino]pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using 5 micron, 30 x 150 mm, XBridge Shield RP18 OBD column, 20-50% acetonitrile-water as eluent, and 10 mM ammonium bicarbonate and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[3- (l -methyl-4- piperidyl)anilino]pyrazine-2-carboxamide formate salt (0.013 g, 14% yield) as a yellow solid. 1H NMR (DMSO-d6, 400 MHz) d 1.99 (4H, q), 2.78 (3H, s), 2.81 (1H, s), 2.97 (3H, d), 3.07 (2H, s), 3.49 (2H, d), 4.02 (3H, s), 6.89 (1H, d), 7.27 - 7.36 (1H, m), 7.39 (1H, d), 7.63 - 7.69 (2H, m), 7.78 (1H, d), 7.92 (1H, br q), 8.54 (1H, s), 8.73 (1H, s), 9.04 (1H, s), 10.1 (1H, s), 11.55 (1H, s). m/z: (ES+), [M+H]+ = 472.3

Example 176

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r 4-(4-methylimidazol-l- vDanilinolpyrazine-2-carboxamide

£aj Methyl.5-(methy]aniinpJ-6 _: (3-nieLhyJimidazoL4J-cJpyndinr7 _: yl). _: 3 _r I4:i4:methyljmidazol- lryJJanilino]pyrazine-2-carbpxylate l-(4-Bromophenyl)-4-methyl -imidazole (76 mg, 0.32 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.96 mmol) and BrettPhos Pd G3 (43 mg, 0.050 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4- (4-methylimidazol-l- yl)anilino]pyrazine-2-carboxylate (0.100 g, 67%) as a yellow solid, m z: (ES+), [M+H]+ = 470.2

{¾.5r£M9thylaminp) _: 6-(3-methylimidazp[4 _: 5-cJpyridin _: 7-yl)-3 _: b4-(4-methylimidazpl-l- y]JanilinpJpyrazine-2-carbpxamide

7 N Methanolic ammonia (14 mL, 98 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(4-methylimidazol-l-y l)anilino]pyrazine-2- carboxylate (100 mg, 0.21 mmol). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm, XBridge Prep OBD Cl 8 column, decreasingly polar mixtures of MeCN-LhO as eluent, and 0.05% trifluoroacetic acid as modifier, to afford 5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(4 -methylimidazol-l- yl)anilino]pyrazine-2-carboxamide (20 mg, 21%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.33 (3H, s), 2.97 (3H, d), 4.07 (3H, s), 7.51 (1H, br s), 7.69 - 7.77 (2H, m), 7.91 (2H, d), 7.96 (1H, d), 7.99 - 8.08 (2H, m), 8.78 (1H, s), 8.87 (1H, s), 9.30 (1H, s), 9.44 (1H, d), 11.84 (1H, s). m/z: (ES+), [M+H]+ = 455.3

Example 177

5-(Methylamino)-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-( T1.2.41triazolor4.3-a1pyri din-6- ylamino)pyrazine-2-carboxamide

£aj. Methyl.. ^(methylaminpJ-^fj-methyHmidazoL^S-cJpyri^^n-T _T ylj. _TJ -iQ^^Jtnazolotfl.j- a]py _. ridin _: 6 _: ylamino)pyrazine:2-carboxylate

XantPhos Pd G4 (37 mg, 0.040 mmol) was added to a suspension of XantPhos (44 mg, 0.080 mmol), methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (120 mg, 0.38 mmol), 6-bromo-[l,2,4]triazolo[4,3-a]pyridine (152 mg, 0.770 mmol), and potassium phosphate (325 mg, 1.53 mmol) in DMF (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-

([l,2,4]triazolo[4,3-a]pyridin-6-ylamino)pyrazine-2-carbo xylate (0.060 g, 36% yield) as a yellow solid. m/z\ (ES+), [M+H]+ = 431.2

(bJ-^-lMethylaminpj _T b-fj-methylimidazptft _^ S-cJpyndin^-yJJ-j^itl^ _^ ^triazpJo^ _^j -alpyridin- 6 -y 1 am i _no)_p_y razi n e-2 - curb ox amide 7 N Methanolic ammonia (12 mL, 84 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-([l,2,4]triazolo[4,3-a]p yridin-6-ylamino)pyrazine-2- carboxylate (50 mg, 0.12 mmol). The resulting mixture was stirred at 80 °C for 5 days. The reaction was then concentrated. Ammonium hydroxide (12.0 mL, 308 mmol) was added. The resulting mixture was stirred at 100 °C for 4 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 19 mm x 250 mm, XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-LLO as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-([l,2,4]triazolo[4,3-a]pyridin-6-ylamino)p yrazine-2-carboxamide (1.960 mg, 4.0% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 3.03 (3H, d), 4.03 (3H, s), 7.36 - 7.56 (2H, m), 7.71 - 7.87 (2H, m), 8.09 (1H, br q), 8.54 (1H, s), 8.75 (1H, s), 9.05

(1H, s), 9.28 (1H, s), 9.42 (1H, s), 11.56 (1H, s). m/z\ (ES+), [M+H]+ = 416.2

Example 178 3-G4-P -Hydroxy- l-methyl-ethvDanilino1-5-(methylamino)-6-(3-methylimidazc> ;r4.5-c1pyridin-

7-vnpyrazine-2-carboxamide

(aJ _. Methyl J _. :X4 _r (l _: hydroxy-!-niethyJ-ethy])anilinq}-5-(|Tiethylairiino)-6 _T (3- m9thyHmidazp£4 ₁ 5 _: c]pyridin _: 7 _: ylJpyrazine-2 _: carboxylate

A mixture of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (150 mg, 0.48 mmol), 2-(4-bromophenyl)propan-2-ol (206 mg, 0.960 mmol), BrettPhos Pd G3 (43 mg, 0.050 mmol), and cesium carbonate (468 mg, 1.44 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (4.8 mL) was added. The resulting slurry was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0 to 0.2% methanolic ammonia as modifier, to afford methyl 3 -[4-(l -hydroxy- 1-m ethyl-ethyl)anilino]- 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazi ne-2-carboxylate (164 mg, 77% yield) as a yellow solid. ¾ NMR (500 MHz, DMSO-d6): d 1.43 (6H, s), 2.92 (3H, d),

3.82 (3H, s), 4.00 (3H, s), 4.93 (1H, s), 7.44 (2H, d), 7.73 (2H, d), 7.92 (1H, br q), 8.48 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.42 (1H, s). m/z: (ES+), [M+H]+ = 448.3

£bJ.3_-[4-(l_ _: Hy_drpxy_-l-methyJ-ethyJ)a.ni_linp]. _: _5-(met_hyJ_amirip)-6:(_3-met_hyJ_irni_d_azp[_4,5_- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide 7 N Methanolic ammonia (6.9 mL, 48 mmol) was added to methyl 3-[4-(l-hydroxy-l-methyl- ethyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxylate (145 mg, 0.320 mmol). The resulting mixture was stirred at 100 °C for 20 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by reverse phase C18 chromatography, using 0 to 100% MeCN-H?0 as eluent, and 0.2% ammonium hydroxide as modifier, to afford 3-[4-(l-hydroxy-l-methyl- ethyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2- carboxamide (105 mg, 75% yield) as a yellow solid. ¾NMR (500 MHz, DMSO-d6): d 1.42 7.72 - 7.75 (1H, m), 7.98 (1H, br q), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.46 (1H, s). m/r (ES+), [M+H]+ = 433.3

Example 179 5-Cvclopropyl-3-rr6-n -hydroxy-1 -methyl-ethyl )-3-pyridyllaminol-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide

(a) 2:i5 _: Bjpmo _: 2-pyridylJprqpan-2-ql

1.4 M Methylmagnesium bromide in 3:1 THF/toluene (5.36 mL, 7.50 mmol) was added to a solution of l-(5-bromo-2-pyridyl)ethanone (1.00 g, 5.00 mmol) in THF (19.6 mL) at 0 °C.

The resulting mixture was stirred at 1 hour while the ice bath expired. The reaction was then cooled to 0 °C, then quenched by slow addition of saturated aqueous ammonium chloride (25 mL). The resulting mixture was stirred at room temperature for 15 minutes. The layers were separated and the aqueous layer was extracted three times with EtOAc. The combined organic layers were washed sequentially with saturated aqueous ammonium chloride and brine, then dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% EtOAc-hexanes as eluent, to afford 2-(5-bromo-2- pyridyl)propan-2-ol (575 mg, 53% yield) as a yellow oil. ¾ NMR (500 MHz, Chloroform-d): d 1.54 (6H, s), 4.40 (1H, s), 7.32 (1H, d), 7.82 (1H, dd), 8.58 (1H, d). m/r (ES+), [M+H]+ = 216.0

{b) _. 5-Cycl _. ciprppyl-3 _: J^[6-(l _: hydrpxy-l _: methyl _: ethyl) _: 3_-p_yridyl]aminpJ _: 6-_(3- methyhmidazp£4 ₁ 5 _: c]pyridin-7 _: yljpyrazine-2 _: carbpxylic _. acid

A mixture of methyl 3-amino-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine- 2-carboxylate (100 mg, 0.31 mmol), 2-(5-bromopyridin-2-yl)propan-2-ol (133 mg, 0.620 mmol), XantPhos Pd G3 (30 mg, 0.03 mmol), and cesium carbonate (301 mg, 0.920 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (3.08 mL) was added, and the resulting slurry was evacuated and backfilled three times with nitrogen, then stirred at 100 °C for 4 hours, then at 80 °C for 48 hours. The reaction mixture was then allowed to cool to room temperature, filtered through Celite, and concentrated. The resulting residue was purified by reverse phase C18 chromatography, using 0 to 50% MeCN-fhO as eluent, and 0.1% formic acid as modifier, to afford 5-cyclopropyl-3-[[6-(l-hydroxy-l-methyl-ethyl)-3- pyridyl]amino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazin e-2-carboxylic acid (0.082 g, 60% yield) as an off-white solid. ¾NMR (500 MHz, DMSO-d6): d 0.89 - 0.96 (2H, m), 1.05 (2H, dt), 1.45 (6H, s), 1.83 - 1.93 (1H, m), 3.99 (3H, s), 5.15 (1H, br s), 7.63 (1H, d), 8.04 (1H, dd), 8.43 (1H, s), 8.44 (1H, s), 8.76 (1H, d), 9.05 (1H, s), 10.50 (1H, br s). m/z\ (ES+), [M+H]+ = 446.2.

_. (c) _. 5-Cyclppropyl-3 _: [[6-(l _: hydroxy-l-methyl-ethyl)-3 _: pyridylJaminp] _.: 6-(3- mpthyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: yljpyraane-2 _: carbpxamide

DIPEA (157 μL, 0.90 mmol) was added to a solution of 5-cyclopropyl-3-[[6-(l-hydroxy-l- methyl-ethyl)-3-pyridyl]amino]-6-(3-methylimidazo[4,5-c]pyri din-7-yl)pyrazine-2-carboxylic acid (80 mg, 0.18 mmol) in DMF (1.7 mL). Ammonium chloride (96 mg, 1.8 mmol) and HATU (137 mg, 0.360 mmol) were sequentially added. The resulting mixture was stirred at room temperature for 20 hours. Additional ammonium chloride (96 mg, 1.80 mmol) and HATU (137 mg, 0.36 mmol) were added. The resulting mixture was stirred at room temperature for 1 hour. The reaction was then filtered, and the filtrate was concentrated. The resulting residue was -purified by reverse phase C18 chromatography, using 0 to 100% MeCN-water as eluent, and 0 to 0.2% ammonium hydroxide as modifier, to afford an off- white solid. This material was further purified silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0.2% methanolic ammonia as modifier, to afford 5-cyclopropyl- 3-[[6-(l-hydroxy-l-methyl-ethyl)-3-pyridyl]amino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (0.036 g, 45% yield) as an off-white solid. ¾NMR (500 MHz, DMSO-d6): d 0.90 - 0.97 (2H, m), 1.04 - 1.11 (2H, m), 1.44 (6H, s), 1.87 - 1.98 (1H, m), 3.99 (3H, s), 5.14 (1H, s), 7.62 (1H, d), 7.88 (1H, br s), 8.04 (1H, dd), 8.13 (1H, br s), 8.44 (1H, s), 8.54 (1H, s), 8.77 (1H, d), 9.05 (1H, s), 11.28 (1H, s)

Example 180

3-r(2-Imino-2-oxo-E3-dihvdro-2-benzothiophen-5-vDaminol-5 -methyl-6-(T- methylbenzimidazol-4-vDpyrazine-2-carboxamide

{aX^Bromo-l _^ S-dihydro-l-benzothipphene

Sodium sulfide (9.10 g, 117 mmol) was added to a solution of 4-bromo-l,2- bis(bromomethyl)benzene (10.0 g, 29.2 mmol) in EtOH (25 mL). The resulting mixture was stirred at 50 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% DCM-petroleum ether as eluent, to afford 5-bromo-l,3-dihydro-2-benzothiophene (3.10 g, 49%) as a white solid; 1HNMR (300 MHz, DMSO-d6) d 4.17 (2H, s), 4.22 (2H, s), 7.27 (1H, d), 7.41 (1H, dd), 7.53 (1H, d); m/r. Poor ionization by LCMS. {¾.Methyl.3-(l,3-dihydro _: 2-benzothiophen _: 5-ylaminoJ-5-rnethyl-6 _: (l _: methylbenzimidazol- 4-yl)pyr¾?ine:2-carbpxylate

Brettphos Pd G3 (122 mg, 0.130 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.67 mmol), 5-bromo-l,3-dihydro-2-benzothiophene (145 mg, 0.670 mmol), and cesium carbonate (658 mg, 2.02 mmol) in 1,4-dioxane (1 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-(l,3- dihydro-2-benzothiophen-5-ylamino)-5-methyl-6-(l-methylbenzi midazol-4-yl)pyrazine-2- carboxylate (0.240 g, 83%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.39 (3H, s), 3.91 (3H, s), 3.92 (3H, s), 4.22 (2H, d), 4.26 (2H, s), 7.26 - 7.34 (2H, m), 7.43 (1H, t), 7.58 -

7.65 (1H, m), 7.68 - 7.73 (1H, m), 7.76 (1H, s), 8.28 (1H, s), 10.07 (1H, s); m/z\ (ES+), [M+H]+ = 432.1

{c)Methy) _. J _. :X(2-imino-2-oxo-l,3-dihydro-2-benzothiophen _: 5-yl)amino]-5-methyl-6-(l- methylbenzimidazgl-4:yl)pyrazine-2-carbpxylate Ammonium carbamate (109 mg, 1.39 mmol) was added to a mixture of methyl 3-(l,3- dihydro-2-benzothiophen-5-ylamino)-5-methyl-6-(l-methylbenzi midazol-4-yl)pyrazine-2- carboxylate (240 mg, 0.56 mmol) and [acetoxy(phenyl)-X3-iodanyl] (537 mg, 1.67 mmol) in MeOH (5 mL). The resulting mixture was stirred at 25 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[(2-imino-2-oxo-l,3-dihydro-2-benzothiophen-5- yl)amino]-5-methyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2-c arboxylate (0.079 g, 31%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.38 (3H, s), 3.88 (3H, s), 3.89 (4H, s),

4.34 (2H, s), 4.40 (2H, d), 7.27 - 7.34 (2H, m), 7.40 (1H, t), 7.64 - 7.71 (2H, m), 7.82 (1H, s), 8.27 (1H, s), 10.08 (1H, s); m/z\ (ES+), [M+H]+ = 463.2 i¾ _. 3rIC?"toiiUQr2rOxo-1 _^ 3-dihydro:2-benzothipphen-5-yl)aming] _. -:5-methy _. l-6-Xl- methyJbenzimidazgl-4 _: yl)pyrazine-2-carbpxamide 7 N Methanolic ammonia (3.0 mL, 21 mmol) was added to methyl 3-[(2-imino-2-oxo-l,3- dihydro-2-benzothiophen-5-yl)amino]-5-methyl-6-(l-methylbenz imidazol-4-yl)pyrazine-2- carboxylate (62 mg, 0.13 mmol). The resulting suspension was stirred at 60 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% trifluoroacetic acid as modifier, to afford 3-[(2- imino-2-oxo-l,3-dihydro-2-benzothiophen-5-yl)amino]-5-methyl -6-(l-methylbenzimidazol-4- yl)pyrazine-2-carboxamide (17 mg, 28%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.48 (3H, s), 4.06 (4H, s), 4.52 (2H, s), 4.58 (2H, s), 7.37 (1H, d), 7.61 - 7.73 (2H, m), 7.73 - 7.80 (1H, m), 7.87 (1H, s), 7.95 (1H, d), 8.00 (1H, s), 8.14 (1H, s), 9.23 (1H, s), 11.48 (1H, s); m/z: (ES+), [M+H]+ = 448.1

Examples 181 and 182 rel-(7^)-3-r4-(Ethylsulfonimidoyl )-3.5-di methyl -anilinol-5-methyl-6-(l -methylbenzimidazol- 4-vDpyrazine-2-carboxamide and rel-fV)-3-r4-(ethylsulfonimidoyl )-3.5-di methyl -anilinol-5- methyl-6-(T-methylbenzimidazol-4-vDpyrazine-2-carboxamide

{4).5:Brpmo-2-ethylsulfanyl-l _: 3-dimethyl-benzene Triethylamine (3.27 mL, 23.5 mmol) was added to a soluion of 4-bromo-2,6-dimethyl- benzenethiol (1.70 g, 7.83 mmol) and bromoethane (1.02 g, 9.40 mmol) in acetonitrile (50 mL). The resulting mixture was stirred at 25 °C for 2 hours. The reaction was then concentrated. The reaction mixture was diluted with EtOAc (250 mL), and washed three times with brine (250 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford 5-bromo-2-ethylsulfanyl-l, 3 -dimethyl-benzene (1.8 g, 94% yield) as a solid; 1HNMR (400 MHz, DMSO-d6) d 1.09 (3H, t), 2.47 (6H, s), 2.68 (2H, q), 7.39 (2H, s). Poor ioniziation by LCMS.

{b)X4-Brqmp-2 _: 6-dimethyl-phenyl)-ethyl-iminq-oxo _: 2if-sulfane Ammonium carbamate (1.21 g, 15.5 mmol) was added to a mixture of 5-bromo-2- ethylsulfanyl-1, 3-dimethyl-benzene (1.900 g, 7.75 mmol) and [acetoxy (phenyl )-l3 -i odany 1 ] acetate (6.24 g, 19.4 mmol) in MeOH (50 mL). The resulting mixture was stirred at 25 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% EtOAc-petroleum ether as eluent, to afford (4-bromo-2,6- dimethyl-phenyl)-ethyl-imino-oxo-λ ⁶ -sulfane (1.38 g, 65%) as a white solid; 1H NMR (400 MHz, DMSO-d6) d 1.13 (3H, t), 2.66 (6H, s), 3.15 (2H, qd), 4.48 (1H, s), 7.47 (2H, s). m/z\ (ES+), [M+H]+ = 275.9

{cXMejfcyl _. SrHXeAyJ _. su^fonimidoylj-S _j S-dimethyl-anilinoJ-S-methyl-bXl- methyJbenzimidazgl-4 _: yl)pyrazine-2-carbqxylate

(4-Bromo-2,6-dimethyl-phenyl)-ethyl-imino-oxo-λ ⁶ -sulfane (418 mg, 1.51 mmol) was added to a suspension of methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (300 mg, 1.01 mmol), Cesium carbonate (986 mg, 3.03 mmol) and BrettPhos Pd G3 (183 mg, 0.200 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. Thionyl chloride (2.00 mL, 27.4 mmol) was added dropwise to a suspension of the resulting residue in MeOH (20 mL) at 0°C. The resulting mixture was stirred at 60 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% MeOH-DCM as eluent, to afford methyl 3-[4-(ethylsulfonimidoyl)-3,5-dimethyl- anilino]-5-methyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2-ca rboxylate (0.096 g, 19%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.17 (3H, dt), 2.44 (3H, s), 2.71 (6H, s),

3.05 - 3.22 (2H, m), 3.91 (6H, s), 4.25 (1H, s), 7.31 (1H, d), 7.43 (1H, t), 7.71 (3H, d), 8.25 (1H, s), 10.19 (1H, s). m/z: (ES+), [M+H]+ = 493.2 {¾J.?l:iK)rJ.:I4:iElhylsulfonimido^J)-3 ₁ 5 _: dimethyl-aynilinp] _i -;5-methy.l _: 6-(.l- metihy.lbenzimidazol-4-yl}p.yr^ine-2-c^bpx^ide.^d reJ.:{S)-J. _: £4 _: (etihy.lsulfpnimidoyl) _: 3 ₃ 5- djMethyJ _. rA0iJj _. nQ]^5:tTiethyl-6-(j-iTiethy!benzimidazol-4 _r yl)pyrazine-2 _: carboxamide 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to (rac)-methyl 3-[4- (ethylsulfonimidoyl)-3,5-dimethyl-anilino]-5-methyl-6-(l-met hylbenzimidazol-4-yl)pyrazine- 2-carboxylate (94 mg, 0.19 mmol). The resulting suspension was stirred at 70 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by preparative chiral- HPLC, using a 3 micron, 4.6 mm x 100 mm, CHIRAL ART Cellulose-SB column, and isocratic 1:1 methyl tert-butyl ether-MeCN as eluent, to afford rel-(R)-3-[4- (ethylsulfonimidoyl)-3,5-dimethyl-anilino]-5-methyl-6-(l-met hylbenzimidazol-4-yl)pyrazine- 2-carboxamide (26 mg, 29%) and rel-(S)-3-[4-(ethylsulfonimidoyl)-3,5-dimethyl-anilino]-5- methyl-6-(l-methylbenzimidazol-4-yl)pyrazine-2-carboxamide (24 mg, 26% yield), each as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.16 (3H, t), 2.46 (3H, s), 2.70 (6H, s), 3.05

- 3.23 (2H, m), 3.91 (3H, s), 4.26 (1H, s), 7.38 - 7.47 (2H, m), 7.69 (3H, s), 7.99 (1H, d), 8.19 (1H, s), 8.27 (1H, s), 11.48 (1H, s). m/z\ (ES+), [M+H]+ = 478.3

Example 183

3-r(2.2-Dioxo-L3-dihvdro-2-benzothiophen-5-vnamino1-5-(me thylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

(a) _. Methyl _. 6:chlpro-3-[(2,2 _r dioxo ₇ l _J 3-dihydro _: 2-benzothiophen-5-yl)amino]-5 ₇ {inethylaminpJpyrazine-2 ₇ carboxylate

DIPEA (600 μL, 3.42 mmol) was added to a mixture of 2,2-dioxo-l,3-dihydro-2- benzothiophen-5-amine (626 mg, 3.42 mmol) and methyl 6-chloro-3-fluoro-5- (methylamino)pyrazine-2-carboxylate (250 mg, 1.14 mmol) in NMP (3 mL). The resulting mixture was heated at 150 °C for 20 hours. The reaction was then diluted with water. The resulting precipitate was collected by filtration and dried under air to afford methyl 6-chloro- 3-[(2,2-dioxo-l,3-dihydro-2-benzothiophen-5-yl)amino]-5-(met hylamino)pyrazine-2- carboxylate (0.169 g, 39%) as a brown solid, m/z: (ES+), [M+H] = 383.1 _. (bJ _.. 6-ChJoro-3 _T ^Q _^ 2-dioxo-lJ-dihydro ₇ 2-benzothiophen-5 _: yl)aiTiinp}-5- _. (rnethylamino)pyrazine-2 ₇ carbpxaiTiide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 6-chloro-3-[(2,2-dioxo- l,3-dihydro-2-benzothiophen-5-yl)amino]-5-(methylamino)pyraz ine-2-carboxylate (85 mg, 0.22 mmol). The resulting suspension was stirred at 100 °C for 20 hours. The reaction was then concentrated. The resulting residue was diluted with with MeCN, then reconcentrated, to afford 6-chloro-3-((2,2-dioxido-l,3-dihydrobenzo[c]thiophen-5-yl)am ino)-5- (methylamino)pyrazine-2-carboxamide (78 mg, 46% yield) as a brown solid. _. (c) _. 3 ₇ l(2,2 ₇ Dioxo-lj ₇ dihy'dro-2 ₇ benzothipphen-5 ₇ yl)arriino_] ₇ 5-(methyJamino)-6 ₇ (3 ₇ methyhmidazp[4 ₁ 5 ₇ c]pyridin ₇ 7 ₇ yl)pyrazine-2 ₇ carbpxamide

CataCXium A Pd G3 (15 mg, 0.020 mmol), bis(pinacolato)diboron (108 mg, 0.420 mmol), 7- bromo-3-methyl-imidazo[4,5-c]pyridine (45 mg, 0.21 mmol), potassium acetate (63 mg, 0.64 mmol), and cataCXium A (7.6 mg, 0.020 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.5 mL) was added. The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

Pd(dppf)Ch (16 mg, 0.020 mmol), cesium fluoride (97 mg, 0.64 mmol), and 6-chloro-3-[(2,2- di oxo-1, 3-dihydro-2-benzothiophen-5-yl)amino]-5-(methylamino)pyrazin e-2-carboxamide (78 mg, 0.21 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-60% MeOH-DCM as eluent, to afford 3-[(2,2-dioxo-l,3-dihydro-2-benzothiophen-5-yl)amino]-5-(met hylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (25 mg, 25%) as a pale yellow solid; 1H NMR (500 MHz, DMSO-d6) d 2.94 (3H, br d), 4.08 (3H, s), 4.44 (2H, s), 4.51 (2H, s), 7.34 (1H, d), 7.49 (1H, br s), 7.66 - 7.74 (1H, m), 7.87 (2H, br s), 7.93 (1H, s), 8.85 (1H, br s), 8.90 (1H, s), 9.34 (1H, br s), 11.68 (1H, s); m/z: (ES+), [M+H]+ = 465.2

Example 184 5-(Methylamino)-3-r(l-methyl-2.2-dioxo-3H-2.1-benzothiazol-5 -vDamino1-6-(3- methylimidazor4.5-c1pyridin-7-yl )pyrazine-2-carboxamide

(aJ _. MMbyl _. ^rcMQro-S-fmethylaminpJ^j-tQ-methyl-^^-dioxOyjH-^ _^ j^benzothiazol-S- ylJ^inpJ.p.yrazine-^-carbgxylate

DIPEA (0.240 mL, 1.37 mmol) was added to a mixture of methyl 6-chloro-3-fluoro-5- (methylamino)pyrazine-2-carboxylate (100 mg, 0.46 mmol) and 1-m ethyl-2, 2-dioxo-3H-2,l- benzothiazol-5-amine (108 mg, 0.55 mmol) in DMA (3 mL). The resulting mixture was stirred at 120 °C for 20 hours. The reaction was then diluted with water (50 mL). The resulting precipitate was collected by filtration and dried under vacuum to afford methyl 6- chloro-5-(methylamino)-3-[(l-methyl-2,2-dioxo-3H-2,l-benzoth iazol-5-yl)amino]pyrazine-2- carboxylate (0.130 g, 72%) as a brown solid; 1HNMR (500MHz, DMSO-d6) d 2.89 (3H, d), 3.02 (3H, s), 3.80 (3H, s), 4.64 (2H, s), 6.92 (1H, d), 7.62 (1H, dd), 7.72 (1H, d), 7.87 (1H, br q), 10.16 (1H, s) m/z: (ES+), [M+H]+ = 398.2

{¾ _. 6rChloro-5-(methylaminp):3-[Q-methyl-2,2-dioxo-3H-2,l- benzothiazol:5- ylJa.ininpJ.pjrazine-^-carbgxamide

Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 6-chloro-5-(methylamino)-3- [(l-methyl-2,2-dioxo-3H-2,l-benzothiazol-5-yl)amino]pyrazine -2-carboxylate (120 mg, 0.30 mmol). The resulting suspension was stirred at 100 °C for 15 hours in a Biotage microwave reactor. The reaction was then concentrated to afford 6-chloro-5-(methylamino)-3-[(l -methyl- 2, 2-dioxo-3H-2,l-benzothiazol-5-yl)amino]pyrazine-2-carboxamid e (0.115 g, 100 %) as a brown solid; (500MHz, DMSO-d6) d 2.92 (3H, d), 3.01 (3H, s), 4.63 (2H, s), 6.91 (1H, d), 7.35 (1H, br s), 7.52 - 7.61 (2H, m), 7.63 (1H, dd), 7.69 (1H, d), 11.32 (1H, s); m/z\ (ES+), [M+H]+ = 383.1

(^.^-(MethyJamingj-j^fl-methyJ-^^^digxg _Tj H-^l^benzgthjazgJ-^yJJamingJ:^-^- methyhmidazg£4 ₁ 5 _: c]pyridin-7 _: ylJpyrazine-2 _: carboxamide

CataCXium A Pd G3 (34 mg, 0.050 mmol), bis(pinacolato)diboron (180 mg, 0.71 mmol), 7- bromo-3-methyl-imidazo[4,5-c]pyridine (100 mg, 0.47 mmol), potassium acetate (139 mg, 1.41 mmol) and cataCXium A (17 mg, 0.050 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (2.5 mL) was added. The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then allowed to cool to room temperature and set aside.

PdCb(dppf) (35 mg, 0.050 mmol), cesium fluoride (215 mg, 1.41 mmol), and 6-chloro-5- (methylamino)-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothiazol-5-yl)amino]pyrazine-2- carboxamide (181 mg, 0.470 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture was added via syringe. The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-60% MeOH-DCM as eluent, to afford 5-(methylamino)-3-[(l-methyl-2,2-dioxo-3H-2,l- benzothiazol-5-yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (40 mg, 18%) as a pale yellow solid; 1H NMR (500MHz, DMSO-d6) d 2.93 (3H, d), 3.02 (3H, s), 4.00 (3H, s), 4.66 (2H, s), 6.94 (1H, d), 7.36 (1H, br s), 7.66 - 7.77 (2H, m), 7.83 (1H, s), 8.01 (1H, br q), 8.51 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.45 (1H, s); m/z (ES+), [M+H]+ = 480.1

Example 185

5-Cvclopropyl-3-r(T-methyl-2.2-dioxo-3H-2.1-benzothiazol- 5-vDaminol-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide {4)MethyL6-chlprg-5-c _j. cj _. opropyl _: 3-[(f _: methyl-2,2-dioxo-3H-2,l-benzothiazol:5- ylJa _. ininoJ _. pyrazine-^-carbgxylate

DIPEA (0.523 mL, 3.00 mmol) was slowly added to a solution of methyl 6-chloro-5- cyclopropyl-3-fluoro-pyrazine-2-carboxylate (0.231 g, 1.00 mmol) and 1 -methyl-2, 2-dioxo- 3H-2,l-benzothiazol-5-amine (0.238 g, 1.20 mmol) in DMF (4.5 mL). The resulting mixture was stirred at 120 °C for 2 h under microwave irradiation. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 6-chloro-5-cyclopropyl-3-[(l-methyl-2,2-dioxo-3H- 2,l-benzothiazol-5-yl)amino]pyrazine-2-carboxylate (0.261 g, 64%) as a flaky, bright orange solid. 1H NMR (500 MHz, CHLOROFORM-d) 1.09 - 1.16 (2H, m), 1.18 - 1.25 (2H, m), 2.48 - 2.60 (1H, m), 3.16 (3H, s), 4.01 (3H, s), 4.35 (2H, s), 6.72 (1H, d), 7.46 (1H, dd), 7.53 (1H, s), 10.04 (1H, s). m/z\ (ES+), [M+H]+ = 409.0

{¾ _. 5rCycloprgpyl-3:^(l-methyl-2 _L 2 _: dipxo-3H-2 _i l _: benzothiazgl-5:yl)aminp}:6-(3- methyHmidazg£4 ₁ 5 _: c]pyridin-7 _: ylJpyrazine-2 _: carbgxylic _. acid

A mixture of methyl 6-chloro-5-cyclopropyl-3-[(l-methyl-2,2-dioxo-3H-2,l-benzoth iazol-5- yl)amino]pyrazine-2-carboxylate (100 mg, 0.24 mmol), 2-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (90 mg, 0.37 mmol), and Pd(dppf)Ch- dichloromethane complex (20 mg, 0.02 mmol) was evacuated and backfilled with nitrogen 3 times. 1,4-dioxane (2.1 mL) was then added, followed by degassed 2 M aqueous potassium phosphate (370 μL, 0.73 mmol). The resulting mixture was stirred at 100 °C for 2 hours under microwave irradiation. The reaction was then diluted with 4:1 dichloromethan/isopropanol, washed with saturated ammonium chloride, dried over sodium sulfate, filtered, and concenrated. The resulting residue was stirred overnight in a mixture of aqueous lithium chloride solution and dichloromethane (2 mL), and catalytic tetrabutyl ammonium iodide. The mixture was then acidified to pH 6 with 1 M HC1 and extracted with dichloromethane. The extract was washed with brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was used in the next step without further purification. {c) _. 5-Cyclgprgpyl-3 _: L(l _: methyJ _. -2 _J 2-digxg-3H _: 2 _J l-benzgthiazgl-5-yl)aming]-6 _: (3 _: methyhmMazg[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbgxamide

HATU (111 mg, 0.290 mmol) was added to a solution of 5-cyclopropyl-3-[(l-methyl-2,2- dioxo-3H-2,l-benzothiazol-5-yl)amino]-6-(3-methylimidazo[4,5 -c]pyridin-7-yl)pyrazine-2- carboxylic acid (120 mg, 0.24 mmol) in DMF (2 mL). DIPEA (213 μL, 1.22 mmol) was added and the mixture was stirred for 15 minutes. Ammonium chloride (65.3 mg, 1.22 mmol) was then added, and the resulting mixture was stirred for 90 minutes. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 1% ammonia as a modifier. The resulting material was dissolved in dichloromethane (50 mL), washed sequentially with saturated ammonium chloride, saturated sodium bicarbonate, 5% lithium chloride, and brine, dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford 5-cyclopropyl-3-[(l-methyl-2,2-dioxo-3H-2,l- benzothiazol-5-yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (0.044 g, 37%) as a yellow solid. 1H NMR (500 MHz, CHLOROFORM-d) 0.88 - 1.03 (2H, m), 1.11 - 1.25 (2H, m), 1.97 - 2.08 (1H, m), 3.15 (3H, s), 4.04 (3H, s), 4.36 (2H, s), 5.46 (1H, br s), 6.73 (1H, d), 7.59 (1H, dd), 7.72 (1H, s), 7.84 (1H, br d), 8.04 (1H, s), 8.66 (1H, s), 8.94 (1H, s), 10.85 (1H, s). m/r. (ES+), [M+H]+ = 491.0

Example 186

5-Methoxy-3-r(T-methyl-2.2-dioxo-3H-2.1-benzothiazol-5-vO aminol-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

{ajMethyd _. e-chlorg-S-methoxy-S^Q-methyl-^^dioxp^SH-^Hbenzgthiazo l-S- y.U4.ining2pyrazine-2-carbgxylate

DIPEA (180 μL, 1.09 mmol) was added to a solution of 1-m ethyl-2, 2-dioxo-3H-2,l- benzothiazol-5-amine (198 mg, 1.00 mmol), and methyl 6-chloro-3-fluoro-5-methoxy- pyrazine-2-carboxylate (200 mg, 0.91 mmol) in DMF (0.73 mL). The resulting solution was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature. The resulting precipitate was collected by filtration to afford methyl 6-chl oro-5-m ethoxy-3 -[(1- methyl-2,2-dioxo-3H-2,l-benzothiazol-5-yl)amino]pyrazine-2-c arboxylate (0.145 g, 40%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 3.05 (3H, s), 3.89 (3H, s), 4.00 (3H, s), 4.70 (2H, s), 6.97 (1H, d), 7.59 (1H, dd), 7.70 (1H, s), 10.09 (1H, s); m/z: (ES+), [M+H]+ = 399.2. {b).Methyl.5-rnethgxy-3 _: [(l _: methyl-2 _J 2-digxg-3H _: 2 _J l-benzgthiazgl-5-yl)amingl _: 6 _: (3 _: methyhmidazg[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carboxylate

Bis(pinacolato)diboron (449 mg, 1.77 mmol), cataCXium A (25 mg, 0.070 mmol), cataCXium A Pd G3 (52 mg, 0.070 mmol), potassium acetate (208 mg, 2.12 mmol), and 7- bromo-3-methyl-imidazo[4,5-c]pyridine (150 mg, 0.71 mmol) were combined in a microwave vial, which was evacuted and backfilled three times with nitrogen. DMF (3.5 mL) was added. The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature and set aside. Cesium fluoride (166 mg, 1.09 mmol), Pd(dppf)Ch DCM adduct (27 mg, 0.040 mmol), and methyl 6-chloro-5-methoxy-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothiazol-5- yl)amino]pyrazine-2-carboxylate (145 mg, 0.360 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation mixture from the previous step was added by syringe. The resulting suspension was sparged with nitrogen for 5 minutes then stirred at 100 °C for 2 hours. The reaction was then allowed to cool to room temperature, diluted with DCM (5 mL), and loaded onto celite. The resulting material was purified by silica gel chromatography, using 0-50% MeOH-DCM as eluent, to afford methyl 5-methoxy-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothiazol-5-yl)amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate as a brown solid, m z: (ES+), [M+H]+ = 496.2.

{c) _. 5:Methpxy-3:^(l-methyl-2 _L 2 _: dipxo-3H-2 _i l-benzothiazpl-5:yl)aminp} _: 6-(3- methyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: ylJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl 5-methoxy-3-[(l -methyl- 2, 2-dioxo-3H-2,l-benzothiazol-5-yl)amino]-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-

2-carboxylate (125 mg, 0.25 mmol). The reaction was stirred at 100 °C for 3 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-50% MeOH-DCM as eluent, to afford 5- methoxy-3-[(l -methyl-2, 2-dioxo-3H-2,l -benzothiazol-5-yl)amino]-6-(3-methylimidazo[4, 5- c]pyridin-7-yl)pyrazine-2-carboxamide (27 mg, 22%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 3.05 (3H, s), 3.95 (3H, s), 3.99 (3H, s), 4.69 - 4.73 (2H, m), 6.99 (1H, d), 7.69 (1H, dd), 7.74 (1H, br d), 7.81 (1H, s), 8.00 (1H, br d), 8.41 (1H, s), 8.63 (1H, s), 9.00 (1H, s), 11.37 (1H, s); m/z: (ES+), [M+H]+ = 481.2.

Example 187

3-r4-(Ll-Dioxo-l,4-thiazinan-4-yl)anilinol-5-(methylamino )-6-(3-methylimidazor4,5- clpyridin-7-vDpyrazine-2-carboxamide

{a)M?thyJ.J.:I4:{Ll:dioxO:.L.4.-thiazinan _: 4-yl)anilingl _: 5-(methylamino)-6-(3- JI ¹ ethyj _.i midazp^^^cjpyri din- 7 ryjjpy razi ne-2:carboxylate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 4-(4-bromophenyl)-l,4-thiazinane 1,1 -dioxide (93 mg, 0.32 mmol), and cesium carbonate (313 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4-(l,l-dioxo-l,4-thiazinan-4-yl)anilino]-5-(methylamino)- 6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.073 g, 44%) as a yellow solid; 1H NMR (300 MHz,

DMSO-d6) 52.91 (3H, d), 3.16 (4H, m), 3.74 (4H, m), 3.83 (3H, s), 4.02 (3H, s), 7.06 (2H, d), 7.72 (2H, d), 7.93 (1H, s), 8.51 (1H, s), 8.54 (1H, s), 9.04 (1H, d), 10.31 (1H, s). m/z\

(ES+), [M+H]+ = 523.1 .(bJ _.J rld-fj _^ l-DioxOyhd-thiazinanrd-yljanilinp^-^fmethylaminoX-Gfj- methylirnidazofd,?- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 3-[4-(l,l-dioxo-l,4- thiazinan-4-yl)anilino]-5-(methylamino)-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-2- carboxylate (55 mg, 0.11 mmol). The resulting suspension was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-(l,l- di oxo-1, 4-thiazinan-4-yl)anilino]-5-(methylamino)-6-(3-methylimidazo [4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (28 mg, 51%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) 52.92 (3H, d), 3.10 - 3.19 (4H, m), 3.68 - 3.75 (4H, m), 3.99 (3H, s), 7.03 (2H, d), 7.31 (1H, s), 7.68 (2H, d), 7.70 (1 H, s), 7.99 (1H, br q), 8.50 (1H, s), 8.71 (1H, s), 8.99 (1H, s), 11.33 (1H, s); m/z: (ES+), [M+H]+ = 508.2 Example 188

3-r4-rrDimethyl(oxo)-λ ⁶ -sulfanylidene1amino1anilino1-5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

{aJ.M.ethyl. J.:I4:£[djmethyl_(_o_xoJ _: _/7; _: sul_fany]j_deneJamin_olaniJ_in_o]. _: 5-(methy]ami_no)-6:(_3- mejdiyHmkdazp£4 _^ 5 _r c]pyridin-7 _r ylJpyr^ine-2 _r c^bpxylate

BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), cesium carbonate (312 mg, 0.96 mmol), and (4-bromophenyl)imino-dimethyl-oxo-λ ⁶ - sulfane (10 mg, 0.04 mmol) in 1,4-dioxane (2 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[[dimethyl(oxo)-λ ⁶ -sulfanylidene]amino]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.070 g, 46% yield) as a yellow solid, m/z·. (ES+), [M+H]+ = 481.2

£bJ.3_-[4_-£[_D_i_methyl(_o_xoJ-/7y_sulfanyJ_i_deneJami n_oJani_li_n_o2 _: _5-(met_hyJ_ami_no)_-6 _: _(3- methyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: ylJpyrazine-2 _: carboxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to a suspension of methyl 3-[4- [[dimethyl(oxo)-λ ⁶ -sulfanylidene]amino]anilino]-5-(methylamino)-6-(3-met hylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (55 mg, 0.11 mmol) in MeOH (0.1 mL). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 10-30% MeCN-FbO as eluent, and 0.1% formic acid as modifier, to afford 3- [4-[[dimethyl(oxo)-λ ⁶ -sulfanylidene]amino]anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (17 mg, 32% yield) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.95 (3H, d), 3.20 (6H, s), 4.04 (3H, s), 6.93 (2H, (1H, s), 11.35 (1H, s); m/z: (ES+), [M+H]+ = 466.1

Example 189

3-i4-iiDimethyl(oxo)-λ ⁶ -sulfanylidenelaminol-2-fluoro-anilinol-5-(methylamino )-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(4)X4^BrQ1130^3:fluorp-phenyl)iminp-dimethyl-oxg.-2y. ⁶ .:Sulfane

Pd ₂ (dba) ₃ (152 mg, 0.170 mmol) was added to a suspension of Xantphos (96 mg, 0.17 mmol), l-bromo-2-fluoro-4-iodo-benzene (500 mg, 1.66 mmol), imino-dimethyl-oxo-λ ⁶ -sulfane (155 mg, 1.66 mmol), and cesium carbonate (1.62 mg, 4.99 mmol) in 1,4-dioxane (20 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford (4-bromo-3 -fluoro-phenyl)i mi no-dim ethyl -oxo-/7-sulfane (0.340 g, 77% yield) as a brown solid. 1H NMR (400 MHz, DMSO-d6) d 3.26 (6H, s), 6.69 - 6.76 (1H, m), 6.82-6.93 (1H, m), 7.44 (1H, t). m/z: (ES+), [M+H]+ = 266.0 {b).Methyl.3-[4-[[dimethyl(^pxpJ-X ^® _: sulfanylidene]aminpJ _: 2-fluprp-anilinp]-5 _: i_methylaminp)- 6-(3 -methy limi dazp [4, 5 -c]py ri din _: 7_-y _. l)py razine-2-carb pxyl ate Brettphos Pd G3 (34 mg, 0.040 mmol) was added to (4-bromo-3-fluoro-phenyl)imino- dimethyl-oxo-λ ⁶ -sulfane (100 mg, 0.38 mmol), methyl 3-amino-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (118 mg, 0.38 mmol), and cesium carbonate (367 mg, 1.13 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-25% MeOH-DCM as eluent, to afford methyl 3-[4-[[dimethyl(oxo)-/7’-sulfanylidene]amino]-2-fluoro-ani lino]-5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.085 g, 45% yield) as a brown solid. 1H NMR (400 MHz, DMSO-d6) d 2.82 (3H, d), 3.25 (6H, d), 3.74 (3H, s), 4.00 (3H, s), 6.70 - 6.80 (1H, m), 6.80 - 6.88 (1H, m), 7.51 (1H, d), 7.96 (1H, br q) 8.35 (1H, td), 8.46

(1H, s), 9.01 (1H, s), 10.44 (1H, s). m/z: (ES+), [M+H]+ = 499.2

{c) _. 3:^4 _: [[Dimethyl(oxp):?if-sulfanylidene}aming] _. -2-fluoro-anilinpJ:5-(methylaming)-6-(3 _: methyHmidazg[4 ₁ 5 _: c]pyridin _: 7 _: yl)pyrazine-2 _: carbgxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[4-[[dimethyl(oxo)-/7- sulfanylidene]amino]-2-fluoro-anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (80 mg, 0.16 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep Cl 8 column, decreasingly polar mixtures of MeCN-ftO as eluent, and 0.1% formic acid as modifier, to afford 3 -[4-[[di methyl (oxo)-/7-sulfanyli denejami no]-2-fl uoro-ani 1 i no]-5-(methyl ami no)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (0.016 g, 20% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.93 (3H, d), 3.23 (6H, s), 4.01 (3H, s), 6.75 - 6.84

9.02 (1H, s), 11.44 (1H, d). 19F NMR (376 MHz, DMSO) d -128.26. m/z: (ES+), [M+H]+ = 484.2

Example 190

3-r4-rrDimethyl(oxo)-λ ⁶ -sulfanylidenelaminol-2.3-difluoro-anilinol-5-(methyla mino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide formate salt

_. (a) _. ( _. 4- _. BXQmg-2,3 _r ditlugrg _: phenyJ)iming-dimethyJ _: gxg-}7’-sulfane

Pd ₂ (dba) ₃ (144 mg, 0.160 mmol) was added to a suspension of Xantphos (91 mg, 0.16 mmol), l-bromo-2,3-difluoro-4-iodo-benzene (500 mg, 1.57 mmol), imino-dimethyl-oxo-λ ⁶ -sulfane (146 mg, 1.57 mmol), and cesium carbonate (1.53 g, 4.70 mmol) in 1,4-dioxane (25 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford (4-bromo-2, 3 -difluoro-phenyl)i mi no-dim ethyl -oco-l ⁶ - sulfane (0.360 g, 81% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 3.32 (6H, s), 6.92-6.98 (1H, m), 7.24 - 7.32 (1H, m). m/r (ES+), [M+H]+ = 283.9 _. (bJ _. Methy! _.. 3 _.2 [4rI[dimethy!(.oxo)-/7 _7S u!fanylidene]aniinoj ₇ 2 _J 3-difluoro-anilinp]-5- {rnethylamino)-6-(3 ₇ methylimidazo[4 ₃ 5 ₇ _cJpyridin-7-yl)pyrazine ₇ 2 ₇ _carboxylate Brettphos Pd G3 (28.9 mg, 0.03 mmol) was added to a suspension of (4-bromo-2,3-difluoro- phenyl)imino-dimethyl-oxo-λ ⁶ -sulfane (100 mg, 0.35 mmol), methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (15 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-[[dimethyl(oxo)-/7-sulfanylidene]amino]-2,3-difluoro- anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.080 g, 49%) as a brown solid. 1H NMR (400 MHz, DMSO-d6) d 2.82 (3H, d), 2.88 (3H, d), 3.74 (3H, s), 4.00 (3H, s), 4.01 (3H, s), 6.98 (1H, d), 8.14 (1H, br q) 8.39 - 8.54 (2H, m), 9.01 (1H, s), 9.05 (1H, s), 10.44 (1H, d). m/r (ES+), [M+H]+ = 517.2

{c)7 _. :I4 ₇ [[Dimethyl(pxp) ₇ X.f _7. sulfanylidene] _. aming] _. -2,3 ₇ diflupro ₇ anilino]-5 ₇ (methylaminp) ₇ 6 ₇ {3:methylimidazo[4 _^ 5 _: c]pyridin ₇ _7 _: yl)pyrazine-2-carbpxamide formate salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3 -[4-[[di methyl (oco)-l ⁶ - sulfanylidene]amino]-2,3-difluoro-anilino]-5-(methylamino)-6 -(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 0.15 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Sunfire prep C18 column, decreasingly polar mixtures of MeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-[[dimethyl(oxo)-/7-sulfanylidene]amino]-2,3-difluoro-an ilino]-5-(methylamino)- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide formate salt (0.018 g, 22% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.93 (3H, d), 3.27 (6H, s), 4.01 (3H, s), 6.97 (1H, td), 7.39 (1H, s), 7.77 (1H, s), 8.01 (1H, br q), 8.17 (1H, br s), 8.25 (1H, td), 8.52 (1H, s), 8.73 (1H, s), 9.03 (1H, s), 11.58 (1H, d). m/r (ES+), [M+H]+ = 502.2

Example 191

3-r4-(El-Dioxo-E2-thiazolidin-2-vnanilinol-5-(methylamino )-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide

{a)M?thyJ.J.:I4:{Ll:diQXQ:L.?r.thiazolidin-2 _: yl)anilino]-5-(methylamino)-6-(3- JI ¹ ethyj _.i midazp^^^cjpyri din- 7 ryjjpy razi ne-2:carboxylate

BrettPhos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of cesium carbonate (312 mg, 0.960 mmol), 2-(4-bromophenyl)-l,2-thiazolidine 1,1-dioxide (106 mg, 0.380 mmol) and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-y l)pyrazine-2- carboxylate (100 mg, 0.32 mmol) in 1,4-dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-(l,l-dioxo-l,2-thiazolidin-2-yl)anilino]-5-(methylamino )-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 49%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.41 (2H, p), 2.92 (3H, d), 3.51 (2H, t), 3.75 (2H, t), 3.84 (3H, s), 4.03 (3H, s), 7.20 - 7.30 (2H, m), 7.85 (2H, d), 7.92 (1H, d), 8.53 (2H, d), 9.06 (1H, s), 10.44 (1H, s). m/z\ (ES+), [M+H]+ = 509.2 {¾ _. 3-[4 _r Xl,l:Pioxo _: l _J 2-thiazolidin:2-yl)anilino]-5-(methylaminp):6-(3-ineth ylimidazo[4,5- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (lOmL, 70.00 mmol) was added to a suspension methyl 3-[4-(l,l- di oxo-1, 2-thiazolidin-2-yl)anilino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (60 mg, 0.12 mmol) in MeOH (10 mL). The resulting mixture was stirred at 80 °C for 3 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 5-30% MeCN-H?0 as eluent, and 0.1% formic acid as modifier to afford 3-[4-(l,l- di oxo-1, 2-thiazolidin-2-yl)anilino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (22 mg, 38%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 2.35 - 2.44 (2H, m), 2.96 (3H, d), 3.49 (2H, t), 3.74 (2H, t), 4.02 (3H, s), 7.19 - 7.30 (2H, m), 7.40 (1H, s), 7.81 (3H, m), 8.01 (1H, d), 8.53 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.52 (1H, s); m/r. (ES+), [M+H]+ = 494.3 Example 192

3-r4-n.l-Dioxothiazinan-2-vDanilino1-5-(methylamino)-6-(3 -methylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

(aJ _. Methyl J _. rld^l _^ jrdjpxpthiazinan-NylJaniJinpl-S^methylaminpJ-b-Q-methy JjmidazobpS- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

Brettphos Pd G3 (58 mg, 0.060 mmol) was added to a suspension of methyl 3-amino-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (100 mg, 0.32 mmol), 2-(4-bromophenyl)thiazinane 1,1-dioxide (93 mg, 0.32 mmol), and cesium carbonate (312 mg, 0.960 mmol) in 1,4-dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4-(l,l-dioxothiazinan-2-yl)anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.107 g, 64%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.77 - 1.87 (2H, m), 2.11 - 2.21 (2H, m), 2.94 (3H, d), 3.25 - 3.29 (2H, m), 3.59 - 3.67

8.54 (1H, s), 9.05 (1H, s), 10.50 (1H, s); m/z: (ES+), [M+H]+ = 523.2 {¾ _. 3-[4 _r Xl ₅ l:Pioxothiazinan-2-yl)anilinp] _. :5-(methylamino)-6 _: Q-methylimidazo[4 _J 5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[4-(l,l-dioxothiazinan-2- yl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin -7-yl)pyrazine-2-carboxylate (89 mg, 0.17 mmol). The resulting suspension was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 100 mm, XSelect CSH Prep C18 OBD column, decreasingly polar mixtures ofMeCN-HiO as eluent, and 0.1% formic acid as modifier, to afford 3-[4-(l,l- dioxothiazinan-2-yl)anilino]-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (22 mg, 26%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.73 — 1.89 (2H, m), 2.08 - 2.23 (2H, m), 2.97 (3H, d), 3.23 - 3.32 (2H, m), 3.56 - 3.68

8.52 (1H, s), 8.73 (1H, s), 9.02 (1H, s), 11.61 (1H, s); m/z: (ES+), [M+H]+ = 508.2 Example 193

3-(2-Fluoro-4-methylsulfonyl-anilino)-5-(methylamino)-6-( 3-methylimidazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

_. (4)N: _. (? _. :Buoxo-4 _: methylsulfonyl-_phenyl)fonnamide Formic acid (2.00 mL, 52.2 mmol) was added to acetic anhydride (2.00 mL, 21.2 mmol). The resulting colorless solution was stirred at 25 C for 30 minutes. 2-fluoro-4-methylsulfonyl- aniline (190 mg, 1.00 mmol) was added. The resulting pale yellow solution was stirred at 25 C for 24 hours. The reaction was concentrated to a colorless oil, then diluted with EtOAc (15 mL) and quenched with saturated aqueous sodium bicarbonate (30 mL). The resulting mixture was stirred for 30 minutes, then separated. The aqueous layer was extracted twice with EtOAc (10 mL each). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford N-(2-fluoro-4-rnethylsulfonyl-phenyl)formamide (0.206 g, 94%) as a white solid; 1HNMR (500 MHz, DMSO-d6) 3.22 (3H, s), 7.74 (1H, br d), 7.83 (1H, dd), 8.40 (1H, br s), 8.45 (1H, br s), 10.55 (1H, br s). m/z : (ES-), [M-H]+ = 216. {¾ _. MethyL6-chloro-3:£2 _: flupxQ-4:methylsulfonyl-anilinp) _. :5-(methylamino)pyrazine-2- carbpxylate and methyl 6-chloro-3-(2:fluoro-N:fprmyl-4-methylsulfonyl _: anilinp)-5- {iFpthylaminpJpyrazine-2 _: carbpxylate

60 wt% Sodium hydride in oil (38 mg, 0.95 mmol) was added to a solution of N-(2-fluoro-4- methylsulfonyl-phenyl)formamide (206 mg, 0.95 mmol) in DMF (3 mL). The reaction was stirred at 25 C for 20 minutes, methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2- carboxylate (186 mg, 0.85 mmol) was added as a solution in DMF (4 mL). The reaction was stirred at 25 C for 16 hours. The reaction was then stirred at 60 C for 2 hours. The reaction was allowed to cool to room temperature, then quenched with water (50 mL). The resulting suspension was filtered to afford a 3:1 mixture of methyl 6-chloro-3-(2-fluoro-4- methylsulfonyl-anilino)-5-(methylamino)pyrazine-2-carboxylat e and methyl 6-chloro-3-(2- fluoro-N-formyl-4-methylsulfonyl-anilino)-5-(methylamino)pyr azine-2-carboxylate (0.192 g, 54%) as a pale yellow solid. This mixture was carried forward directly to the next step.

Major product: 1H NMR (500MHz, DMSO-d6, 27°C) 2.99 (3H, d), 3.84 (3H, s), 7.72 - 7.97

(2H, m), 8.14 (1H, br q), 8.84 (1H, t), 10.90 (1H, d). m/z\ (ES+), [M+H]+ = 389.0

Minor product: 1H NMR (500MHz, DMSO-d6, 27°C) 3.24 (3H, d), 3.97 (3H, s), 7.72 - 7.97

(2H, m), 8.48 (1H, t), 8.88 (1H, br d), 10.62 (1H, d). m/z\ (ES+), [M+H]+ = 417.0(c) Methyl

3^(2r _. flupro _: 4-methylsulfonyl _: anilino)-5 _: (meth _j )amino) _: 6-(3-methylimidazo[4 _: 5-c)pyridin _: 7- yl)pyrazine-2 _: carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (0.159 g, 0.750 mmol), bis(pinacolato)diboron (0.476 g, 1.88 mmol), cataCXium A Pd G3 (0.055 g, 0.080 mmol), cataCXium A (0.027 g, 0.080 mmol), and potassium acetate (0.221 g, 2.25 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (3.5 mL) was added and the resulting mixture was stirred at 80 C for 24 hours. The reaction was then allowed to cool to room temperature at set aside.

Methyl 6-chloro-3-(2-fluoro-4-methylsulfonyl-anilino)-5-(methylamin o)pyrazine-2- carboxylate (0.192 g, 0.460 mmol), Pd(dppf)C12*dichloromethane adduct (0.038 g, 0.050 mmol), and cesium fluoride (0.210 g, 1.38 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation reaction mixture was added via syringe. The resulting mixture was stirred at 100 C for 2 hours. The reaction was then diluted with DCM (25 mL) and loaded onto Celite, then purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford methyl 3-(2-fluoro-4-methylsulfonyl-anilino)-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.108 g, 48%) as a pale yellow solid; 1H NMR (500MHz, DMSO-d6, 27°C) 2.96 (3H, d), 3.24 (3H, s), 3.85 (3H, s), 4.01 (3H, s), 7.81 (1H, dd), 7.87 (1H, dd), 8.04 (1H, br q), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, t), 9.07 (1H, s), 11.08 (1H, d). m/r. (ES+), [M+H]+ = 486.0

(dJ.Jrf^-Fluoro-^-methylsuJipnyl^anilinojA-fmethyJ.ami^nq j^^-ij-methyli^midazq))^- c]pyridin _: 7 _: yl)pyrazine-2 _: carbpxamide

Lithium hydroxide monohydrate (93 mg, 2.22 mmol) was added to a suspension of methyl 3- (2-fluoro-4-methylsulfonyl-anilino)-5-(methylamino)-6-(3-met hylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (108 mg, 0.22 mmol) in MeOH (1 mL), THF (1 mL), and water (1 mL). The resulting suspension was stirred at 50 C for 1 hour. The reaction was allowed to cool to room temperature, then treated with 2 M aqueous HC1 (1.3 mL, 2.6 mmol). The reaction was then concentrated. The resulting residue was dissolved in DMF (2 mL). HATU (0.100 g, 0.26 mmol), ammonium chloride (0.118 g, 2.20 mmol), and DIPEA (0.1 mL, 0.57 mmol) were sequentially added to the reaction mixture. The resulting orange solution was stirred at 25 C for 24 hours. Additional HATU (0.167 g, 0.44 mmol) and DIPEA (0.15 mL, 0.86 mmol) were added and the reaction was stirred at 25 C for 60 hours. The reaction was diluted with water (50 mL), then extracted three times with 3:1 chloroform-isopropanol. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated onto Celite. This material was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent and 0-1% ammonia as modifier, to afford a yellow solid. This material was then suspensed in MeOH (5 mL), filtered, and rinsed with MeOH (5 mL), to afford 3-(2-fluoro-4- methylsulfonyl-anilino)-5-(methylamino)-6-(3-methylimidazo[4 ,5-c]pyridin-7-yl)pyrazine-2- carboxamide (19 mg, 18%) as a yellow solid; 1H NMR (500MHz, DMSO-d6, 27°C) 2.99 (3H, br d), 3.23 (3H, s), 4.01 (3H, s), 7.52 (1H, br s), 7.72 - 7.84 (2H, m), 7.87 (1H, br s), 8.08 (1H, br q), 8.52 (1H, s), 8.73 (1H, s), 8.94 - 9.11 (2H, m), 12.25 (1H, br d). m/z\ (ES+), [M+H]+ = 471.1 Example 194

(R)-3-r4-(Ethylsulfonimidovnanilinol-5-(methylamino)-6-(3 -methylimidazor4.5-clpyridin-7-

_(a) tert-Buty! _. (R):N _r X(4-brpmpphenylJ-ethjJ _: oxO:?if-sulfanylidene] _. carbamate DIPEA (1.69 mL, 9.67 mmol) was added to a solution of DMAP (79 mg, 0.64 mmol), άϊ-tert- butyl dicarbonate (1.50 mL, 6.45 mmol), and (R)-(4-bromophenyl)-ethyl-imino-oxo-/7- sulfane in THF (2 mL). The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% EtOAc-petroleum ether as eluent, to afford tert-butyl (R)-N-[(4-bromophenyl)-ethyl- oxo-λ ⁶ -sulfanylidene]carbamate (300 mg, 26.7 %) as a white solid; 1H NMR (300 MHz, DMSO-d6) d 1.09 (3H, t), 1.25 (9H, s), 3.45 - 3.61 (2H, m), 7.76 - 7.86 (2H, m), 7.87 - 7.97 (2H, m). Did not ionize on LCMS.

_. (bJ _. Methy! _. (.RJ: _. 3 _.2 [4r(ethylsu!fonimidpyJ)ani^lino]-5-(iriethxlarriino)-6 -(3 _ri riethy _. lirnidazo{4,5- c]pyridm-7 _: yljpyrazine-2 _: carbpxylate

BrettPhos Pd G3 (29 mg, 0.030 mmol) was added to a suspension of cesium carbonate (312 mg, 0.960 mmol), tert-butyl (R)-N-[(4-bromophenyl)-ethyl-oxo-/7-sulfanylidene]carbamate (333 mg, 0.960 mmol), and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.320 mmol) in 1,4-dioxane (15mL). The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting was residue was taken up in MeOH (10 mL). Thionyl chloride (2.00 mL, 27.4 mmol) was added and the resulting mixture was stirred at 60°C for 2 hours. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM, to afford methyl (R)-3-[4-(ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-m ethylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (60 mg, 39%) as a yellow solid; lH NMR (300 MHz, DMSO-d6) d 1.24 (3H, t), 2.94 (3H, d), 3.86 (3H, s), 3.95 (3H, q), 4.15 (3H, s), 7.69 - 7.77 (1H, m), 8.04 (2H, d), 8.26 (2H, d), 8.73 (1H, s), 9.01 (1H, s), 9.65 (1H, s), 10.97 (1H, s); m/z\ (ES+), [M+H]+ = 481.2

£cJdR)-3:b4:_(Et_hyJ_suJfonimj_dpjJJan_i_Hno]_-5 _: _(methyj_am_i_npJ-6-(_3_-methyj_i_mi_dazc ₎ [4,_5_- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to a suspension of methyl (R)-3-[4- (ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (60 mg, 0.12 mmol) in MeOH (10 mL). The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a lOOA, 5 pm, 19 mm X 250 mm SunFire C18 OBD Prep Column, using 10-19% MeCN-H?0 as eluent and 0.1% formic acid as modifier, to afford (R)-3-[4-(ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-m ethylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (28 mg, 48%) as a yellow solid; lH NMR (300 MHz, DMSO-d6) d 1.09 (3H, t), 2.99 (3H, d), 3.11 (2H, q), 4.03 (4H, s), 7.52 (1H, s), 7.84 (3H, m), 7.96 - 8.11 (3H, m), 8.54 (1H, s), 8.74 (1H, s), 9.05 (1H, s), 11.96 (1H, s). (ES+) [M+H]+ = 466.1 Example 195

(S)-3-r4-(EthylsulfonimidovDanilino1-5-(methylamino)-6-(3 -methylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide .(aj4ert-Butyl (S)-N-b(4 _: brompphenyJ) _: ebhyJ-oxp-/7 _r sulfanyJidene]carbarnate

DMAP (79 mg, 0.64 mmol) was added to a solution of di-/er/-butyl carbonate (1.50 mL, 6.45 mmol), (S)-(4-bromophenyl)-ethyl-imino-oxo-λ ⁶ -sulfane (800 mg, 3.22 mmol), and DIPEA (1.69 mL, 9.67 mmol) in THF (2 mL). The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-petroleum ether, to afford tert-butyl (S)-N-[(4- bromophenyl)-ethyl-oxo-/7-sulfanylidene]carbamate (350 mg, 31%) as a white solid; 1H NMR (300 MHz, DMSO-d6) d 1.09 (3H, t), 1.25 (9H, s), 3.54 (2H, qd), 7.78 - 7.84 (2H, m), 7.90 - 7.95 (2H, m); Did not ionize on LCMS.

_. (bJ _. Melhy! _. (SjA:L4-(Hhylsulfonimjdoyl)anjJj _. nQl:5r(methylarnino)-6-(3-rnethyJimidazo[4 _J 5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

BrettPhos G3 Pd (29 mg, 0.030 mmol) was added to a suspesion of cesium carbonate (310 mg, 0.96 mmol), tert-butyl (S)-N-[(4-bromophenyl)-ethyl-oxo-/7-sulfanyli dene] carbarn ate (330 mg, 0.96 mmol), and methyl 3-amino-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol) in 1,4-dioxane (10 mL). The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was taken up in MeOH (8 mL) and thionyl chloride (2.00 mL, 27.4 mmol) was added. The resulting mixture was stirred at 60°C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM, to afford methyl (R)-3-[4-(ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (70 mg, 46%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.22 - 1.26 (3H, m), 2.94 (3H, d), 3.86 (3H, s), 3.95 (2H, t), 10.98 (1H, s); imidoyl NH signal buried under broad residual water peak; m/z\ (ES+), [M+H]+ 481.2

_. (cJ _. (Sj:3-[4-(EthylsuJipnimidpyJjanilinoj ₇ 5-(rnethxlamino)-6 _r (3 _: methylirriidazp[4 ₁ 5 _: c]pyridin _: 7 _: ylJpyrazine-2 _: carboxamide 7 N Methanolic ammonia (2.0 mL, 14 mmol) was added to methyl (S)-3-[4-

(ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methyli midazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (65 mg, 0.14 mmol). The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a lOOA, 5 pm, 30 mm X 150 mm SunFire C18 Prep Column, using 5-15% MeCN-FhO as eluent and 0.1% formic acid as modifier, to afford (S)-3-[4- (ethylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (17 mg, 27%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.09 (3H, t), 2.99 (3H, d), 3.11 (2H, m), 3.99 - 4.20 (4H, m), 7.52 (1H, s), 7.84 (3H, m), 7.96 - 8.11 (3H, m), 8.54 (1H, s), 8.74 (1H, s), 9.05 (1H, s), 11.96 (1H, s); m/z\ (ES+) [M+H]+ 466.1

Examples 196 and 197 rel-(R)-3-r4-(Isopropylsulfonimidoyl )anilinol-5-(methylamino)-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide and rel-(S)-3-r4-(isopropylsulfonimidovOanilinol-5- (methyl ami no )-6-(3-methyli mi dazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(^XA-BrompphenylJrimjnp-isppropyl-pxo-kf-sulfane

Ammonium carbamate (0.844 g, 10.8 mmol) was added to a solution of l-bromo-4- isopropylsulfanyl-benzene (1.00 g, 4.33 mmol) and and [acetoxy (phenyl )-l3 -i odany 1 ] acetate (4.18 g, 13.0 mmol) in MeOH (10 mL). The resulting solution was stirred at 25 °C for 3 hours. The resulting residue was purified by C18 reverse phase chromatography, using 5-90% MeCN-H ₂ 0 as eluent, to afford (4-bromophenyl)-imino-isopropyl-oxo-/7-sulfane (0.900 g, 79%) as a yellow oil. 1HNMR (400 MHz, DMSO-d6) d 1.01 - 1.18 (6H, m), 3.16 - 3.28 (1H, m), 4.26 (1H, s), 7.77 (2H, d), 7.82 (2H, d); m/z\ (ES+), [M+H]+ = 262.0 {¾4ert _: Butyl _. N-[ _. (4-bromophenyl)-isoprppyl:pxp-?i ^® -sulfany _. lidene]carbamate DMAP (0.350 g, 2.86 mmol) was added to a solution of (4-bromophenyl)-imino-isopropyl- oxo-/7-sulfane (1.50 g, 5.72 mmol), di-tert-butyl dicarbonate (2.66 mL, 11.4 mmol), and DIPEA (3.00 mL, 17.16 mmol) in DCM (15 mL). The resulting solution was stirred at 25 °C for 18 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-petroleum ether as eluent, to afford tert-butyl N-[(4- bromophenyl)-isopropyl-oxo-/7-sulfanyli dene] carbamate (0.875 g, 42%) as a white solid; 1H NMR (400 MHz, DMSO-d6) d 1.09 (3H, d), 1.22 (9H, s), 1.27 (3H, d), 3.60 - 3.70 (1H, m), 7.74 (2H, d), 7.92 (2H, d). m/z: (ES+), [M+H]+ = 362.2

{c)MethyIJ _. :I4:{N:teit-butpxycarbonyl-S:isgpropyl-sulfpnimidoyl)a nilinp]-5-(methylaminp): 6-(3 -methy limi dazp[4 _: 5 -c]py ri din _: 7-y.l)py ^razine-2-carbpxyl ate

Brettphos Pd G3 (87 mg, 0.10 mmol) was added to a suspension of methyl 3-amino-6-(3- methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5-(methylamino)pyrazin e-2-carboxylate (150 mg,

0.48 mmol), tert-butyl N-[(4-bromophenyl)-isopropyl-oxo-/7-sulfanylidene]carbamate (347 mg, 0.96 mmol), and cesium carbonate (468 mg, 1.44 mmol) in 1,4-dioxane (8 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% MeOH-DCM as eluent, to afford methyl 3-[4-(N-tert-butoxycarbonyl-S-isopropyl- sulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (0.153 g, 54%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.14 (3H, d), 1.25 (9H, s), 1.28 (3H, d), 2.95 (3H, d), 3.64 (1H, heptet), 3.86 (3H, s), 4.02 (3H, s), 7.77 (2H, d), 8.01 (1H, br q), 8.14 (2H, d), 8.51 (1H, s), 8.54 (1H, s), 9.07 (1H, s), 10.80 (1H, s). m/z\ (ES+), [M+H]+ = 595.6

(dJ.Methyj j-tfl-iisppjppyJsulfpnimidpylJanjHnpj-^bmethylamjnpJ-b-bj-rn ethyljmidazp^^S- c]pyridin-7 _: yl_)pyrazine-2 _: carbpxylate

4 M HC1 in 1,4-dioxane (3.0 mL, 12 mmol) was added to a suspension of methyl 3-[4-(N-tert- butoxycarbonyl-S-isopropyl-sulfonimidoyl)anilino]-5-(methyla mino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (140 mg, 0.24 mmol) in MeOH (3 mL). The resulting mixture was stirred at 25 °C for 2 hours. The reaction was then concentrated to afford methyl 3-[4-(isopropylsulfonimidoyl)anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.112 g, 96%) as a yellow solid. 1HNMR (300 MHz, DMSO-d6) d 1.30 (3H, d), 1.39 (3H, d), 2.95 (3H, d), 3.86 (4H, s), 4.15 (3H, s), 4.18 - 4.26 (1H, m), 7.73 (1H, br q), 8.02 (2H, d), 8.28 (2H, d), 8.74 (1H, s), 9.03 (1H, s), 9.68 (1H, s), 10.99 (1H, s); m/z\ (ES+), [M+H]+ = 495.2

(eJieL-iEJr.J _T L^QsopropyJsujfonimidoyJJaniJj.noj-S-fmethylaminoj^^-i j-methylimidazoXd _; ^- c]pyridin-7 _: yljpyrazine-2 _: carbpxamide andxel _r XS) _: 3-[4-(isoprppylsulfonimidqyl)anilino]-5 _: {rnethylaminp)-6-(3-methylimidazo[4 _3. 5-c]pyridin-7-yl)pyrazine: _. 2-carboxamide 7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to methyl 3-[4- (isopropylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methyl imidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (92 mg, 0.19 mmol). The resulting mixture was stirred at 80 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 50 mm x 150 mm XSelect CSH Prep Cl 8 OBD column, decreasingly polar mixtures of MeCNMhO as eluent, and 0.1% formic acid as modifier, to afford a yellow solid. This material was further purified by preparative chiral HPLC, using a Chiralpak IH3 column, isocratic 1:1 MeOH-IPA as eluent, and ammonia as modifier, to afford rel-(R)-3-[4-(isopropylsulfonimidoyl)anilino]-5-(methylamino )-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (7.5 mg, 8.2%) and rel-(S)-3-[4- (isopropylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methyl imidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (18 mg, 20%), each as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 1.11 - 1.19 (6H, m), 2.99 (3H, d), 3.12 - 3.23 (1H, m), 3.94 (1H, s), 4.02 (3H, s), 7.49 (1H, s), 7.74 - 7.82 (2H, m), 7.84 (1H, s), 7.98 - 8.07 (3H, m), 8.53 (1H, s), 8.74 (1H, s), 9.04 (1H, s), 11.95 (1H, s); m/z\ (ES+), [M+H]+ = 480.1

Example 198

3-r4-(tert-Butylsulfonimidovnanilinol-5-(methylamino)-6-( 3-methylimidazor4.5-clpyridin-7- vDpyrazine-2-carboxamide

{^MethyJ.J.riflrtertrbutylsulfanylanilinpJ-S^^ethylaminpj ^-iS-methylimidazptfl _^ S- c]pyridin-7 _: yljpyrazine-2 _: carbpxylate BrettPhos Pd G3 (130 mg, 0.15 mmol) was added to a mixture of cesium carbonate (312 mg, 0.960 mmol), l-bromo-4-tert-butylsulfanyl-benzene (352 mg, 1.44 mmol) and methyl 3- amino-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl) pyrazine-2-carboxylate (300 mg, 0.96 mmol) in 1,4-dioxane (40 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-(4-tert- butylsulfanylanilino)-5-(methylamino)-6-(3-methylimidazo[4,5 -c]pyridin-7-yl)pyrazine-2- carboxylate (0.250 g, 55%) as a yellow solid; 1H NMR (300 MHz, DMSO-d6) d 1.26 (9H, s), 2.95 (3H, d), 3.85 (3H, s), 4.02 (3H, s), 7.44 - 7.54 (2H, m), 7.83 - 7.93 (2H, m), 7.99 (1H, br q), 8.51 (1H, s), 8.55 (1H, s), 9.06 (1H, s), 10.57 (1H, s); m/r. (ES+), [M+H]+ = 478.2 {¾ _. Methyl _. 3-[4-(tert-butylsulfonimidpy)Janilino]-5 _: (methylamino):6-(3-methylimidazo[4,5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

Ammonium carbamate (82.0 mg, 1.05 mmol) was added to a suspension of [acetoxy(phenyl)- /J-iodanyl] acetate (405 mg, 1.26 mmol), methyl 3-(4-tert-butylsulfanylanilino)-5- (methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine -2-carboxylate (200 mg, 0.42 mmol) in MeOH (20mL). The resulting mixture was stirred at 25 °C for 3 hours. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[4-(tert-butylsulfonimidoyl)anilino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (0.070 g, 33%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.25 (9H, s), 2.95 (3H, d), 3.86 (3H, s), 3.91 - 4.00 (1H, m), 4.02 (3H, s), 7.79 - 7.83 (2H, m), 7.99 - 8.03 (1H, m), 8.04 - 8.12 (2H, m), 8.51 (1H, s), 8.55 (1H, s), 9.07 (1H, s), 10.77 (1H, s); m/z\ (ES+), [M+2H] ²⁺ = 255.2 {c).3:^4:(tert-ButyHulfgnimidoyl)anilinq]. _: 5-(methylamino)-6-(3-methylimidazo[4 _J 5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxamide

7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[4-(tert- butylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (60 mg, 0.12 mmol) in MeOH (10 mL). The resulting suspension was stirred at 80 °C for 10 hours. The reaction was then concentrated. The resulting residue was purified by preparative SFC, using a 5 micron, 20 mm x 250 mm, Triart Diol-NP column, isocratic 35% MeOH-sC0 ₂ as eluent, and 8 mM ammonia as modifier, to afford 3-[4-(tert- butylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (12 mg, 21%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.25 (9H, s), 3.00 (3H, d), 3.90 (1H, s), 4.03 (3H, s), 7.51 (1H, d), 7.76 - 7.82 (2H, d), 7.86 (1H, s), 7.96 - 8.15 (3H, m), 8.54 (1H, s), 8.74 (1H, s), 9.05 (1H, s), 11.97 (1H, s); m/z\ (ES+), [M+H]+ = 494.3 Example 199

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vO-3-r 4-(T- methylsulfonylcvclopropyDanilinolpyrazine-2-carboxamide

{aX5 _:i (Methyl^jnp)-6 _: X3 _: methyHmid^p£4 ₁ 5 _: c]pyridin-7 _r yl)-3-[4-Cl- methydsulfpnylcyclppropyl)anilinp] _. pyrazine-2-carbpxylic acid

A mixture of methyl 3-amino-6-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-5- (methylamino)pyrazine-2-carboxylate (75 mg, 0.24 mmol), l-bromo-4-(l- methylsulfonylcyclopropyl)benzene (79 mg, 0.29 mmol), BrettPhos Pd G3 (22 mg, 0.020 mmol) and sodium tert-butoxide (69 mg, 0.72 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (2 mL) was added, and the mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was acidified with IN HC1, then washed with ethyl acetate. The aqueous layer was concentrated. The resulting residue was used in the next step without further purification, assuming 100% yield. {¾ _. 5_-(Methylambnp) _: _6-(_3_-methyhmidazp _. [4 _: 5_-cJpyridin _: _7_-yl)_-3 _: b4-Q- methy) _. sulfpnylcyclpprppyl)anilinpJpyrazine-2-carbpxMnide DIPEA (0.25 mL, 1.4 mmol) was added to a suspension of 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l-methylsulfonylcycl opropyl)anilino]pyrazine-2- carboxylic acid (118 mg, 0.240 mmol), ammonium chloride (51.2 mg, 0.96 mmol), and HATU (180 mg, 0.48 mmol) in DMF (2 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-8% MeOH-DCM, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l-methylsulfonylcycl opropyl)anilino]pyrazine-2- carboxamide (32 mg, 27%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d ppm 1.23 - 1.36 (2H, m), 1.56 - 1.68 (2H, m), 2.87 (3H, s), 2.98 (3H, d), 4.03 (3H, s), 7.42 (1H, br s), 7.53 (2H, d), 7.79 (1H, br s), 7.85 (2H, d), 8.03 (1H, br q), 8.53 (1H, s), 8.74 (1H, s), 9.04 (1H, s), 11.70 (1H, s; m/z\ (ES+), [M+H]+ 493.3

Example 200

5-Methoxy-6-(3-methylimidazor4.5-clpyridin-7-vO-3-r4-(T- methylsulfonylcvclopropyDanilinolpyrazine-2-carboxamide

_. (4) _. Methy _. l _. 3:amino _: 5-methgxy-6:(3-methylimidazo[4 _i 5-c]pyridin-7:yl)pyrazine-2- carboxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (200 mg, 0.94 mmol), bis(pinacolato)diboron (359 mg, 1.41 mmol), potassium acetate (278 mg, 2.83 mmol), cataCXium A Pd G3 (69 mg, 0.090 mmol), and cataCXium A (34 mg, 0.090 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. DMF (5 mL) was added and the reaction was heated to 80 °C for 20 hours. The mixture was allowed to cool to room temperature and set aside.

A mixture of methyl 3-amino-6-chloro-5-methoxy-pyrazine-2-carboxylate (410 mg, 1.88 mmol), PdCb(dppf)-DCM adduct (77 mg, 0.090 mmol) and cesium fluoride (286 mg, 1.88 mmol) was evacuated and backfilled three times with nitrogen. The borylation reaction mixture was added to the vial via syringe. The vial was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-amino-5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (158 mg, 53%) as a light brown solid; 1H NMR (500 MHz, METHANOL-d4) d ppm 3.88 - 3.92 (3H, m), 3.93 (3H, s), 4.07 (3H, s), 8.37 (1H, s), 8.44 (1H, s), 8.98 (1H, s). The NH2 peak exchanged out; m/r. (ES+), [M+H]+ 315.2 _. (bJ _. 5rMethpxy-6-(3 ₇ methylimidazo{4,5 _r c}pyridin-7-yl)-3-[4-(l- methyHulfpnylcyclppropyl)anilinp] _. pyrazine:2 _: carbpxylic acid

A mixture of methyl 3-amino-5-methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyra zine-2- carboxylate (60 mg, 0.19 mmol), l-bromo-4-(l-methylsulfonylcyclopropyl)benzene (63 mg, 0.23 mmol), BrettPhos Pd G3 (17 mg, 0.020 mmol) and sodium tert-butoxide (55.0 mg, 0.57 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (2 mL) was added, and the mixture was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was acidified with IN aqueous HC1, then washed with ethyl acetate. The aqueous layer was then concentrated. The resulting residue was used directly in the next step without further purification, assuming 100% yield. (cJ.NMethpxy-b^bj^methyhrnidazpbd _^ ii^cJpyridin-J.ryJJrJ.-Id.-fj.:. methylsulfpnylcyclpprppyl)anilinp] _. pyrazine:2 _: carbpxamide DIPEA (0.199 mL, 1.14 mmol) was added to a suspension of 5-methoxy-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[4-(l-methylsulfonylcycl opropyl)anilino]pyrazine-2- carboxylic acid (94 mg, 0.19 mmol), ammonium chloride (41 mg, 0.76 mmol), and HATU (145 mg, 0.380 mmol) in DMF (2 mL). The resulting mixture was stirred at 25 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-8% MeOH-DCM, to afford 5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[4-(l-methylsulfonylcyclopropyl)anilino]py razine-2-carboxamide (4 mg, 4.3%) as a light yellow solid; 1H NMR (500 MHz, DMSO-d6) d ppm 1.24 - 1.32 (2H, m), 1.57 - 1.64 (2H, m), 2.86 (3H, s), 3.97 (3H, s), 3.99 (3H, s), 7.55 (2H, d), 7.74 - 7.83 (3H, m), 8.03 (1H, br s), 8.40 (1H, s), 8.62 (1H, s), 8.99 (1H, s), 11.61 (1H, s). m/z\ (ES+), [M+H]+ 494.4

Example 201

5-Methoxy-6-(3-methylimidazor4.5-clpyridin-7-vD-3-r(T-met hylpyrazol-4- vDaminolpyrazine-2-carboxamide

{a)M?thyJ..6 _: chlprg-5-methpxy-3 _: ^(l-methylpyrazol _: 4-ylJaminoJpyrazine-2 _: carboxylate

1-Methylpyrazol-4-amine (106 mg, 1.09 mmol) was added to a solution of methyl 6-chloro-3- fluoro-5-methoxy-pyrazine-2-carboxylate (200 mg, 0.91 mmol) and DIPEA (0.475 mL, 2.72 mmol) in DMF (15 mL). The resulting mixture was stirred at 100 °C for 2 hours.

The reaction was then concentrated to afford methyl 6-chloro-5-methoxy-3-[(l- methylpyrazol-4-yl)amino]pyrazine-2-carboxylate (250 mg, 93%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 3.82 (3H, s), 3.84 (3H, s), 4.07 (3H, s), 7.67 - 7.75 (1H, m), 7.99 (1H, d), 9.92 (1H, s). m/r. (ES+), [M+H]+ 298.1 £b)_Methyl 5_-methg_xy-6 _: (_3-met_hyJ_im_i_d_azo[_4,5_-c]pyridin_-7:y]).:3-[(.l- rnethyJpyrazol_ _: _4- y _. U¾rninp] _. pyrazine-2-carbgxylate

PdCh(dppf) (49.2 mg, 0.07 mmol) was addedto a suspension of (3-methylimidazo[4,5- c]pyridin-7-yl)boronic acid (143 mg, 0.81 mmol) cesium fluoride (204 mg, 1.34 mmol) and methyl 6-chloro-5-methoxy-3-[(l-methylpyrazol-4-yl)amino]pyrazine-2 -carboxylate (200 mg, 0.67 mmol) in DMF (5 mL). The resulting mixture was stirred at 100 °Cfor 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-methoxy-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(l-methylpyrazol-4-yl)a mino]pyrazine-2-carboxylate (150 mg, 57%) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 3.85 (3H, s), 3.86 (3H, s), 3.96 (3H, s), 3.98 (3H, s), 7.79 (1H, s), 8.11 (1H, s), 8.38 (2H, s), 9.01 (1H, s), 10.08 (1H, s). m/r. (ES+), [M+H]+ = 395.2

{cj _. S-Methgxy-b^Q^methylimidazgbT.S^cJpyridin-J _. ry _. OrS-fi.l-methylpyrazgl-d- yU¾rning}pyrazine-2-carbgxamide

7 N Methanolic ammonia (0.714 mL, 5.00 mmol) was added to a suspension of methyl 5- methoxy-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(l-methylp yrazol-4-yl)amino]pyrazine-

2-carboxylate (110 mg, 0.28 mmol) in MeOH (lOmL). The resulting mixture was stirred at 70 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm C18 column, 5 to 20% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5-methoxy-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[(l-methylpyrazol-4-yl)amino]pyrazine-2-ca rboxamide (45 mg, 41% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 3.86 (3H, s), 3.99 (3H, s), 4.00 (3H, s),

11.00 (1H, s) m/z: (ES+), [M+H]+ = 380.2

Example 202

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-yl )-3-GP -tetrahvdropyran-4-ylpyrazol- 4-vDaminolpyrazine-2-carboxamide

{a)MethyL6-chlprg-5-(methylarninp) _. :3-[(l-tetrahydropyran-4 _: ylpyrazol-4- ylJa.ininoJ.pyrazine-^-carbgxylate

DIPEA (0.24 mL, 1.4 mmol) was added to a mixture of methyl 6-chloro-3-fluoro-5- (methylamino)pyrazine-2-carboxylate (60 mg, 0.27 mmol) and l-tetrahydropyran-4- ylpyrazol-4-amine (55 mg, 0.33 mmol) in acetonitrile (2 mL). The resulting mixture was stirred at 120 °C for 3 hours in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-100% EtOAc-hexanes as eluent, to afford methyl 6-chloro-5-(methylamino)-3-[(l-tetrahydropyran- 4-ylpyrazol-4-yl)amino]pyrazine-2-carboxylate (83 mg, 83%) as a yellow solid, m/z: (ES+), [M+H]+ = 367.2

{b).Methyl.5_-Xmethylammg)-6 _: 0 _: methyhmidazg£4 ₁ 5 _: c]pyridin-7_ _: ylJ _: 3-_[(l-tetrahydrgpyran-4_- ylpyra?oj _. :4-yl)aminp]pyrazine-2-carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (60 mg, 0.28 mmol), bis(pinacolato)diboron (79 mg, 0.31 mmol), potassium acetate (83 mg, 0.85 mmol), cataCXium A Pd G3 (21 mg, 0.030 mmol), and cataCXium A (10 mg, 0.030 mmol) were combined in a microwave vial, which was then evacuated and backfilled three times with nitrogen. DMF (2 mL) was added and the resulting mixture was stirred at 80 C for 20 hours. The mixture was allowed to cool to room temperature and set aside.

Methyl 6-chloro-5-(methylamino)-3-[(l-tetrahydropyran-4-ylpyrazol-4 -yl)amino]pyrazine-2- carboxylate (103 mg, 0.280 mmol), PdCh(dppf)-DCM adduct (23 mg, 0.030 mmol) and cesium fluoride (86 mg, 0.56 mmol) were combined in a microwave vial, which was evacuated and backfilled three times with nitrogen. The borylation reaction mixture was added to the vial via syringe. The vial was evacuated and backfilled twice with nitrogen. The resulting mixture was stirred at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(l - tetrahydropyran-4-ylpyrazol-4-yl)amino]pyrazine-2-carboxylat e (37 mg, 28%) as a light brown solid. m/z\ (ES+), [M+H]+ = 464.4

(cJ.5-(MethyJ ami np)-6-(3 -methyl imj_dazo£4 ₁ 5-cdpyri_di_n-_7_-yJJ-3-l((l_ _: _te_trahy_dropyran _: _4_- y]pyrazpJ. _: 4-jJ)amino]pyrazine-2-carbpxamide

7 N Methanolic ammonia (2 mL, 14 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(l-tetrahydropyran-4-yl pyrazol-4-yl)amino]pyrazine-2- carboxylate (37 mg, 0.080 mmol). The resulting mixture was stirred at 120 °C for 3 hours, then at 140 °C for 1 hour. The reaction was concentrated. The resulting residue was suspended in 2M aqueous KOH (0.50 mL, 1.0 mmol), MeOH (1 mL), and THF (1 mL). The resulting mixture was stirred at 25 °C for 16 hours. The reaction was then quenched with 1M aqueous HC1 (1.2 mL, 1.2 mmol). The resulting mixture was concentrated, then taken up in DMF (1 mL). Ammonium chloride (17 mg, 0.32 mmol), HATU (61 mg, 0.16 mmol), and DIPEA (0.084 mL, 0.48 mmol) were sequentially added. The resulting mixture was stirred at 25 °C for 1 hour. The reaction was concentrated. The resulting residue was purified by silica gel chromatography, using 0-8% MeOH-DCM, to afford 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(l-tetrahydropyran-4-yl pyrazol-4-yl)amino]pyrazine-2- carboxamide (22 mg, 61%) as a yellow solid; 1H NMR (500 MHz, DMSO-d6) d ppm 1.88 - 2.07 (4H, m), 3.00 (3H, d), 3.49 (2H, td), 3.93 - 4.00 (2H, m), 4.02 (3H, s), 4.32 - 4.43 (1H, m), 7.29 (1H, br s), 7.67 (1H, br s), 7.77 (1H, s), 8.01 (1H, br q), 8.18 (1H, s), 8.52 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.01 (1H, s); m/z\ (ES+), [M+H]+ = 449.3

Example 203 3-r(l-Isopropylpyrazol-4-vDamino1-5-(methylamino)-6-(3-methy limidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

£4j.M.ethyl_ J_-flupro-_5-(m_et_hyJami_no)-6 _: _(_3-m_et_hyJ_i_mi_d_azo[_4,_5-c]pyridi_n-7:y]J.p.y.ra zi_n_e-2- carbpxylate

CataCXium A Pd G2 (2.52 g, 3.77 mmol) was added to a mixture of 7-bromo-3-methyl- imidazo[4,5-c]pyridine (4.00 g, 18.9 mmol), potassium acetate (5.55 g, 56.6 mmol), bis(pinacolato)diboron (9.58 g, 37.7 mmol), and bis(l-adamantyl)-butyl-phosphonium tetrafluorob orate (1.68 g, 3.77 mmol) in 1,4-dioxane (1 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then allowed to cool to room temperature. Methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2-carboxylate (4.14 g, 18.9 mmol), and cesium fluoride (8.60 g, 56.6 mmol) were added to the reaction mixture under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-15% MeOH-DCM as eluent, to afford methyl 3-fluoro-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (1.90 g, 32%) as an orange solid; ¾ NMR (300 MHz, DMSO-d6) d 2.83 (3H, d), 3.81 (3H, s), 4.02 (3H, s), 7.89 (1H, br q), 8.48 (1H, s), 8.50 (1H, s), 9.12 (1H, s); m/z\ (ES+), [M+H]+ = 317.0 iM _. Methy! _. 3-[Q-isppxopylpjx^ol-4-yl)aming] _. -5-(methylMnino)-6-(3-methylimidazp[4 _J 5- c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

Methyl 3-fluoro-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2- carboxylate (100 mg, 0.32 mmol) was added to a solution of 1-isopropylpyrazol -4-amine (79 mg, 0.63 mmol) and DIPEA (170 μL, 0.95 mmol) in DMSO (10 mL). The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[(l-isopropylpyrazol-4-yl)amino]-5-(methylamino)-6-(3-meth ylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (0.090 g, 68%) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 1.44 (6H, d), 2.97 (3H, d), 3.82 (3H, s), 4.02 (3H, s), 4.42-4.54 (1H, m), 7.78 (1H, s), 7.92 (1H, br q), 8.19 (1H, s), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.07 (1H, s); m/z: (ES+), [M+H]+ = 422.2

{c) _. 3:l(lrIsppxQpylpyrazol-4-yl)ammo]-5 _: {methylaminq)-6-(3_-methylimidazo[4 ₃ 5_-c]pyndin-

7ryi)pyr¾?ine:2-carbpxamide 7 N Methanolic ammonia (1.0 mL, 7.0 mmol) was added to methyl 3-[(l-isopropylpyrazol-4- yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxylate (70 mg, 0.17 mmol). The resulting mixture was stirred at 80 °C for 4 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 30 mm x 150 mm Xselect CSH OBD column, 2-25% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-[(l-isopropylpyrazol-4-yl)amino]-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (27 mg, 40%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 1.43 (6H, d), 2.98 (3H, d), 4.00 (3H, s), 4.40-4.52 (1H, m), 7.27 (1H, s), 7.65 (1H, s), 7.72 (1H, s), 7.98 (1H, br q), 8.14 (1H, s), 8.51 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 10.97 (1H, s); m/z: (ES+), [M+H]+ = 407.2

Example 204

3-rri-(El-Dioxothian-4-vnpyrazol-4-yllaminol-5-(methylami no)-6-(3-methylimidazor4.5- clpyridin-7-vDpyrazine-2-carboxamide iaXMetihyI _. 3-bromp-6 _r chlpro-5-(methylagmino)pyrazine:2-carbpxylate tert-Butyl nitrite (143 mg, 1.38 mmol) was added to a mixture of bromotrimethylsilane (120 μL, 0.92 mmol) and methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (100 mg, 0.46 mmol) in dibromomethane (10 mL) under nitrogen. The resulting mixture was stirred at 60 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-20% EtOAc-petroleum ether, to afford methyl 3-bromo-6-chloro-5-(methylamino)pyrazine-2-carboxylate (0.060 g, 47% yield) as a yellow solid; 1HNMR (300 MHz, DMSO-d6) d 2.91 (3H, d), 3.80 (3H, s), 8.20 (1H, q); m/z (ES+), [M+2+H]+ = 281.9

{bJ _. Methyl _. 6-cMpro-3 _: [[ 1 -( 1 , 1 -dioxothian-4:yl)pyrazol-4:yl Jaming] _. :5 : {rnethylaminoJpyrazine-2 _: carbpxylate

Cesium carbonate (232 mg, 0.710 mmol) was added to a suspension of methyl 3-bromo-6- chloro-5-(methylamino)pyrazine-2-carboxylate (100 mg, 0.36 mmol), l-(l,l-dioxothian-4- yl)pyrazol-4-amine (115 mg, 0.530 mmol) and XantPhos Pd G3 (68 mg, 0.070 mmol) in 1,4- dioxane (10 mL). The resulting mixture was stirred at 80 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 6-chloro-3-[[l-(l,l-dioxothian-4-yl)pyrazol-4- yl]amino]-5-(methylamino)pyrazine-2-carboxylate (0.080 g, 54%) as a brown solid; 1H NMR (300 MHz, DMSO-d6) d 2.20 - 2.49 (4H, m), 2.83 - 3.04 (4H, m), 3.18 (3H, br d), 3.78 (3H, s), 4.56 (1H, dt), 7.80 (1H, s), 7.83 - 7.94 (1H, m), 8.09 (1H, s), 9.93 (1H, s); m/z: (ES+), [M+H]+ = 415.0

(?) Methyl _. 3 _: £ [1 -(1,1 - d i o x pthian- 4 _: y 1 ) p y razoJ-4 _: yl] amino_]-5-(methylamino)-6 _: (3 _: methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

7-Bromo-3-methyl-imidazo[4,5-c]pyridine (41 mg, 0.19 mmol) was added to a mixture of bic(pinacolato)diboron (122 mg, 0.480 mmol), cataCXium A tetrafluorob orate (13 mg, 0.020 mmol), CataCXium A Pd G2 (8.6 mg, 0.020 mmol), and potassium acetate (57 mg, 0.58 mmol) in DMF (10 mL) under nitrogen. The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature. To this reaction mixture, Pd(dppf)Ch DCM adduct (14 mg, 0.020 mmol), cesium fluoride (88 mg, 0.58 mmol), and methyl 6-chloro-3-[[l-(l,l-dioxothian-4-yl)pyrazol-4-yl]amino]-5-(m ethylamino)pyrazine-2- carboxylate (80 mg, 0.19 mmol) were added. The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, to afford methyl 3-[[l-(l,l-dioxothian- 4-yl)py ^razo l-4-yl] ^ar ni ⁿ °]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine- 2-carboxylate (0.060 g, 61%) as a yellow solid; 1HNMR (400 MHz, DMSO-d6) d 2.24 - 2.46 (4H, m), 2.91 (3H, d), 3.14 - 3.19 (2H, m), 3.21 - 3.43 (2H, m), 3.74 (3H, s), 4.00 (3H, s), 4.55 - 4.67 (1H, m), 7.88 (1H, s), 8.20 (1H, s), 8.52 (1H, s), 8.98 (1H, s), 9.05 (1H, s). The two NH protons were broadened to baseline. {¾.3rILlrXLl"PiQxpAian-4 _: yl)pyrazol-4:yl]aminc)]-5-(methylaymino)-6 _: {3 _: methyHmidazp^S^cJpyridi^T _j ylJpyrazine-l^carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[[l-(l,l-dioxothian-4- yl)pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimidazo[4, 5-c]pyridin-7-yl)pyrazine-2- carboxylate (55 mg, 0.11 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC using a 5 micron, 19 mm x 250 mm XSelect CSH Prep Cl 8 OBD column, 2-24% MeCN-ThO as eluent, and 0.1% formic acid as modifier, to afford 3-[[l-(l,l-dioxothian-4-yl)pyrazol-4- yl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxamide (1.2 mg, 2.1%) as a yellow solid; 1H NMR (400 MHz, DMSO-d6) d 2.29-2.43 (4H, m), 2.98 (3H, d), 3.19-3.51 (4H, m), 4.01 (3H, s), 4.54 - 4.64 (1H, m), 7.29 (1H, s), 7.67 (1H, s), 7.82 (1H, s), 8.01 (1H, br q), 8.18 (1H, s), 8.52 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.02 (1H, s); m/z: (ES+), [M+H]+ = 497.2

Example 205

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vD-3-n T-(T -methyl-4- piperidvDpyrazol-4-yllaminolpyrazine-2-carboxamide

(a) _. Methyl _. 5:(methylaminpJ-6:(3-methyJirnidazp[4,5-c]pyridin-7 _T y!) _T 3-[[l-( l-methyl-4 _T plp _. endyl)pyrazp!-4-yllaminp]pyrazine _: 2-carboxylate

DIPEA (221 pL, 1.26 mmol) was added to a solution of l-(l-methyl-4-piperidyl)pyrazol-4- amine (91 mg, 0.51 mmol) and methyl 3-fluoro-5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (80 mg, 0.25 mmol) in DMSO (8 mL). The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then diluted with DCM and washed sequentially with water and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(3-methylimidazo[4,5- c]pyridin-7-yl)-3-[[l-(l-methyl-4-piperidyl)pyrazol-4-yl]ami no]pyrazine-2-carboxylate (0.075 g, 62% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-i/6) d 2.24 (7H, d), 2.49

(4H, s), 2.96 (3H, d). 3.27 (1H, s), 3.81 (3H, s), 4.01 (3H, s), 6.97 (1H, dd), 7.91 (1H, br q),

8.18 (1H, s), 8.50 (2H, d), 9.03 (1H, s), 10.08 (1H, s). m/z: (ES+), [M+H]+ = 477.3 .(b) _. 5 - (Methyl amino) _: 6-(3 _. -methy limi dazo [4, 5 -cjp _. y ri din _: 7-yl)-3 _: [[ 1 -( 1 - methy ;] -4- pip.9.ri.dyl).p.yrazol-4-yliamino]pyrazine _: 2_-carboxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[l-(l-methyl-4-piperidy l)pyrazol-4-yl]amino]pyrazine- 2-carboxylate (75 mg, 0.16 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 x 250 mm, YMC-Actus Triart C18 as column, 20-35% MeCN- water as eluent, and 10 mM ammonium carbonate and 0.1% ammonium hydroxide as modifier, to afford 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[l -(l-methyl- 4-piperidyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide (0.016 g, 22% yield) as a yellow solid. 1H NMR (DMSO-d6, 400 MHz) d 1.92 (2H, qd), 2.04 (4H, td), 2.20 (3H, s), 2.84 (2H, br q), 8.15 (1H, s), 8.52 (1H, s), 8.71 (1H, s), 9.00 (1H, s), 10.99 (1H, s). m/z: (ES+), [M+H]+ = 462.3

Example 206

5-(Methylamino)-6-(T -methylbenzimidazol-4-vD-3-rr3-methyl-l-(T -methyl -4- piperidvDpyrazol-4-vnamino1pyrazine-2-carboxamide formate salt

_. (a) tert-Butyl _. 4-X3 _r methyl-4-nitro:pyrazql:l _. -yl)piperidine-l-carbgxylate 3-Methyl-4-nitro-lH-pyrazole (2.00 g, 15.7 mmol) was added to a solution of tert-butyl 4- hydroxypiperidine-l-carboxylate (2.00 g, 9.94 mmol), triphenylphosphine (3.91 g, 14.9 mmol), and DTBAD (3.43 g, 14.9 mmol) in THF (40 mL). The resulting mixture was stirred at 25°C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 50% EtOAc-petroleum ether, to afford a 1 : 1 mixture of tert-butyl 4-(3-methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate and tert-butyl 4-(5- methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate (1.50 g, 24% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.42 (9H, s), 1.75 - 1.89 (4H, m), 2.43 (3H, s), 2.82 - 2.90 (2H, m), 3.97 - 4.06 (2H, m), 4.29 - 4.44 (1H, m), 8.86 (1H, s). m/z\ (ES+), [M-tBu+H]+ = 255.1

{bj4ert _: Butyl _. 4-(4_-aming-3-methyl-pyrazpl-l:ylJpipendine:l-carboxyl ate A mixture of 1 : 1 tert-butyl 4-(3-methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate and tert-butyl 4-(5-methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate (2.00 g, 3.22 mmol) and 10 wt% palladium on carbon (0.171 g, 0.161 mmol) in MeOH (15 mL) was stirred under a hydrogen atmosphere at 25 °C for 2 hours. The reaction was then filtered through celite. The resulting residue was purified by silica gel chromatography to afford a 1 : 1 mixture of tert- butyl 4-(4-amino-3-methyl-pyrazol-l-yl)piperidine-l-carboxylate and tert-butyl 4-(4-amino- 5-methyl-pyrazol-l-yl)piperidine-l-carboxylate (1.500 g, 83 %) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.41 (9H, s), 1.69 - 1.89 (4H, m), 1.99 (3H, s), 2.85 (2H, br s), 3.92 - 4.15 (5H, m), 7.01 (1H, s). m/z\ (ES+), [M+H]+ = 281.2

£cJ.Methyl__3 :£[_[_-( j -tert_-bufgxy_carb_onyJ-4_-p_i_p_eri_dyJJ _: _3_-methy]_-p_yrazgJ_-4 _: y]Jamin_o].-6-chJ_oro- .5 ₂ (ni.9thyJamm.o)pyrazi_ne _: _2-carbgxyJate

A 1 : 1 mixture of tert-butyl 4-(4-amino-3-methyl-pyrazol-l-yl)piperidine-l-carboxylate and tert-butyl 4-(4-amino-5-methyl-pyrazol-l-yl)piperidine-l-carboxylate (1.50 g, 2.68 mmol) was added to a solution of methyl 6-chloro-3-fluoro-5-(methylamino)pyrazine-2-carboxylate (0.705 g, 3.21 mmol) and DIPEA (1.40 mL, 8.03 mmol) in DMSO (20 mL). The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 50% EtOAc-petroleum ether as eluent, to afford a mixture of regioisomers. This material was further purified by reverse phase HPLC, using a 5 micron, 2 cm x 25 cm DAICEL DCpak P4VP column, isocratic 28% IPA in SCO2 as eluent, and 0.5% 2M methanolic ammonia as modifier, to afford methyl 3-[[l- (l-tert-butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4-yl]am ino]-6-chloro-5- (methylamino)pyrazine-2-carboxylate (0.300 g, 23% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 1.41 (9H, s), 1.64-1.79 (2H, m), 1.94 - 2.04 (2H, m), 2.15 (3H, s), 2.82 - 2.92 (2H, m), 2.94 (3H, d), 3.79 (3H, s), 3.96 - 4.09 (2H, m), 4.19-4.29 (1H, m), 7.85 (1H, br q), 8.04 (1H, s), 9.84 (1H, s). m/r. (ES+), [M+H]+ = 480.2 {¾.Methyl.3-[[.l-Q-tert-butpxycarbpny.l _: 4-j)j.peridy.lJ-3-methyl _: pyrazpj[-4 _: yriamino] _: 5- {¾ethylaminoJ-6-(l-methylbenzimidazol _: 4-yl)pyrazine-2 _: carbpxylate PdCb(dppf) (23 mg, 0.030 mmol) was added to a suspension of methyl 3-[[l-(l-tert- butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4-yl]amino]-6-c hloro-5- (methylamino)pyrazine-2-carboxylate (150 mg, 0.31 mmol), (l-methylbenzimidazol-4- yl)boronic acid (110 mg, 0.63 mmol), and cesium fluoride (142 mg, 0.94 mmol) in 1,4- dioxane (10 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford methyl 3-[[l-(l-tert- butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4-yl]amino]-5-( methylamino)-6-(l- methylbenzimidazol-4-yl)pyrazine-2-carboxylate (0.120 g, 67% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.42 (9H, s), 1.66-1.78 (2H, m), 1.95-2.05 (2H, m), 2.23 (3H, s), 2.82 - 2.90 (2H, m), 2.95 (3H, d), 3.82 (3H, s), 3.92 (3H, s), 3.98-4.07 (2H, m), 4.22 - 4.35 (1H, m), 7.40 - 7.49 (2H, m), 7.64 - 7.72 (1H, m), 8.03 (1H, br q), 8.21 (1H, s), 8.35 (1H, s), 10.00 (1H, s). m/r. (ES+), [M+H]+ = 576.4

{e)MethyL5:Xmethylamino)-6 _: Q-methylbenzimidazol-4-yl)-3 _: ^[3 -methyl- 1 -(4- piP.9Xidy!).p.yrazol-4-yJ2ami_no]pyrazi_ne _: _2-cnAoxyJ_at_e_tri_fl_uproacetate Methyl 3-[[l-(l-tert-butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4 -yl]amino]-5- (methylamino)-6-(l-methylbenzimidazol-4-yl)pyrazine-2-carbox ylate (120 mg, 0.21 mmol) was added to a solution of TFA (2.0 mL, 26 mmol) in DCM (10 mL). The resulting mixture was stirred at 25 °C for 3 hours. The reaction was then concentrated. The resulting solid was collected by filtration, washed with petroleum ether (100 mL), and dried under vacuum to afford methyl 5-(methylamino)-6-(l-methylbenzimidazol-4-yl)-3-[[3-methyl-l -(4- piperidyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate trifluoroacetate (0.090 g, 73% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.02 - 2.13 (2H, m), 2.15 - 2.21 (2H, m), 2.25 (3H, s), 2.93 (3H, d), 3.12 (2H, q), 3.38 (2H, d), 3.81 (3H, s), 4.04 (3H, s), 4.39-4.46 (1H, m), 7.53 (1H, s), 7.58-7.65 (2H, m), 7.91 (1H, br q), 8.20 (1H, s), 8.42 - 8.50 (1H, m), 8.58 - 8.67 (1H, m), 10.07 (1H, s). The piperidine NH signal was broadened to baseline, m/r (ES+), [M+H]+ = 476.3 if) _. Methyl _. 5-(methy/lamino):6-(l-methylbenzimidazpl-4 _: ylJ-3-[[3 _: methyl-l-(l -methyl-4- plperidyl)pyrazo!-4-yl}amino]pyrazine _: 2-carbpxylate 37% Aqueous formaldehyde (23 μL, 0.31 mmol) was added to a mixture of sodium triacetoxyborohydride (194 mg, 0.920 mmol) and methyl 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(4-piperidyl)pyrazol -4-yl]amino]pyrazine-2- carboxylate trifluoroacetate (90 mg, 0.15 mmol) in DCM (10 mL). The resulting mixture was stirred at 25 °C for 3 hours. The reaction was then diluted with DCM (50 mL) and washed twice with saturated aqueous sodium bicarbonate (50 mL each). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford methyl 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(l-methyl-4-piperidy l)pyrazol-4- yl]amino]pyrazine-2-carboxylate (0.080 g, quantitative) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 1.85 - 1.93 (2H, m), 1.98 - 2.07 (4H, m), 2.19 (3H, s), 2.22 (3H, s), 2.79- 2.87 (2H, m), 2.96 (3H, d), 3.81 (3H, s), 3.91 (3H, s), 3.98 - 4.07 (1H, m), 7.37 - 7.48 (2H, m), 7.64-7.70 (1H, m), 8.08 (1H, br q), 8.21 (1H, s), 8.31 (1H, s), 9.99 (1H, s). m/z\ (ES+), [M+H]+ = 490.3

.(g).5.-(M9.thy!amino) _: 6-( 1.rmethylbenzimidazql-4 _: yl)-3 -[[3 _ _: methyl- 1 -( 1 -methyl -4- plpe _. ndyl)pyrazo!-4 _: yl}amino]pyrazine _: 2-caAoxarnide fprmate _. salt 7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(l-methyl-4-piperidy l)pyrazol-4- yl]amino]pyrazine-2-carboxylate (100 mg, 0.20 mmoL). The resulting mixture was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 mm x 150 mm Sunfire prep C18 column, 2-15% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(l-methyl-4-piperidy l)pyrazol-4- yl]amino]pyrazine-2-carboxamide formate salt (0.034 g, 31% yield) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) d 1.83-2.05 (4H, m), 2.10-2.17 (2H, m), 2.21 (3H, s), 2.26 (3H, s), 2.55-2.95 (2H, m), 2.99 (3H, d), 3.92 (3H, s), 4.00-4.11 (1H, m), 7.29 (1H, s), 7.41 (1H, t), 7.60 (1H, s), 7.60-7.68 (2H, m), 8.19-8.24 (2H, m), 8.26 (1H, s), 8.35 (1H, s), 10.97 (1H, s). m/z: (ES+), [M+H]+ = 475.2

Example 207

3-r(L3-Dimethylpyrazol-4-vnamino1-5-(methylamino)-6-(3-me thylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

£aj Methyl J.rlQ.j-dime^Jpyrazol.-^-yjjamAnol-S-CmethylarninpJ-^-fl-met hy.limidazpI^.S- c]pyridm-7 _: yljpyrazine-2 _: carbpxylate

DIPEA (248 mE, 1.42 mmol) was added to a solution of 3-fluoro-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (150 mg, 0.47 mmol) and 1,3- dimethylpyrazol-4-amine (105 mg, 0.95 mmol) in DMSO (10 mL). The resulting mixture was stirred at 120 °C for 16 hours. The reaction was then allowed to cool to room temperature, diluted with ice water, and filtered. The filter cake was collected to afford methyl 3-[(l,3- dimethylpyrazol-4-yl)amino]-5-(methylamino)-6-(3-methylimida zo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (0.160 g, 83% yield) as brown soild. 1H NMR (400 MHz, DMSO- d6) d 2.22 (3H, s), 2.95 (3H, d), 3.79 (3H, s), 3.83 (3H, s), 4.02 (3H, s), 7.92 (1H, br q), 8.09 (1H, s), 8.49 (1H, s), 8.53 (1H, s), 9.03 (1H, s), 10.02 (1H, s). m/r. (ES+), [M+H]+ = 408.2 .(bJ _. 3rIk!.,3-pirnethylpyrazol-4 _T yl)amino]^-5 ₇ (methylamino)-6-(3-rnethylimidazo[4 _J 5-c]pyridinr _. 7_-_yl)pyrazine _: 2-carbpxamide

7 N Methanolic ammonia (12 mL, 84 mmol) was added to methyl 3-[(l,3-dimethylpyrazol-4- yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxylate (160 mg, 0.39 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by preparative HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, decreasingly polar mixtures of MeCN- H2O as eluent, and 0.1% formic acid as modifier, to afford 3-[(l,3-dimethylpyrazol-4- yl)amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxamide (0.039 g, 25% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.19 (3H, s), 2.97 (3H, d), 3.78 (3H, s), 4.01 (3H, s), 7.28 (1H, br s), 7.68 (1H, br s), 8.00 (1H, br q), 8.08 (1H, s), 8.52 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.04 (1H, s). m/r. (ES+), [M+H]+ = 393.3

Example 208

5-(Methylamino)-6-(3-methylimidazor4.5-clpyridin-7-vO-3-r r3-methyl-l -(2.2.2- trifluoroethvnpyrazol-4-yllaminolpyrazine-2-carboxamide

{a)MethyIJ _. :bromo-6 _: chloro:5-(methylamino)pyrazine:2-carboxylate tert- Butyl nitrite (1.428 g, 13.85 mmol) was added portionwise to a solution of methyl 3- amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate (1.00 g, 4.62 mmol) in dibromomethane (10 mL) at 0°C. Bromo(trimethyl)silane (1.20 mL, 9.23 mmol) was added. The resulting mixture was stirred at 60 °C for 2 hours under nitrogen. The resulting precipitate was dried under vacuum. The resulting material was purified by silica gel chromatography, using 0 to 50% EtOAc-petroleum ether as eluent, to afford methyl 3-bromo- 6-chloro-5-(methylamino)pyrazine-2-carboxylate (1.200 g, 93% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.90 (3H, d), 3.79 (3H, s), 8.18 (1H, br q). m/z: (ES+), [M+2+H]+ = 282.1

£bJ.Methyj_6_-cbJojp_-5:(myfhyj_aminoJ _: _3_-[£3 _: m_ethyJ_ _: j_-(2 ₁ 2,_2-trifl_uoroethyJ_)pyrazoJ_ _: 4_- y.Ua.illinpJ.pyrazine-^-carbgxylate

Methyl 3-bromo-6-chloro-5-(methylamino)pyrazine-2-carboxylate (400 mg, 1.43 mmol) was added to a suspension of cesium carbonate (1.39 g, 4.28 mmol), 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazol -4-amine (255 mg, 1.43 mmol), and Pd(dppf)C12 (156 mg, 0.210 mmol) in 1,4-dioxane (40 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 100% EtOAc-petroleum ether as eluent, to afford methyl 6- chloro-5-(methylamino)-3-[[3-methyl-l-(2,2,2-trifluoroethyl) pyrazol-4-yl]amino]pyrazine-2- carboxylate (0.240 g, 44% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) d 2.20 (3H, s), 2.96 (3H, d), 3.81 (3H, s), 5.07 (2H, q), 7.93 (1H, br q), 8.17 (1H, s), 9.92 (1H, s). m/z: (ES+), [M+H]+ = 379.1

(cJ.MethyJJi^methylaminpJ-b^fj-methyHmidazolA^-cJpyridin- Y. _T ylj. _TJ -Cl _j -rnethyl-lri?^^- trifluorgethyl)pyrazgl-4 _: ylJaming}pyrazine-2-carbgxylate

Methyl 6-chloro-5-(methylamino)-3-[[3-methyl-l-(2,2,2-trifluoroethy l)pyrazol-4- yl]amino]pyrazine-2-carboxylate (240 mg, 0.63 mmol) was added to a suspension of cesium fluoride (289 mg, 1.90 mmol), 2-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l, 3,6,2- dioxazaborocane (155 mg, 0.630 mmol), and Pd(dppf)C12 (70 mg, 0.10 mmol) in 1,4-dioxane (30 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, to afford methyl 5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-t rifluoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (130 mg, 42% yield) as a yellow solid. 1H NMR (DMSO- d6, 400 MHz) d 2.26 (3H, s), 2.94 (3H, d), 3.83 (3H, s), 4.01 (3H, s), 5.09 (2H, q), 7.92 (1H, br q), 8.29 (1H, s), 8.49 (1H, s), 8.52 (1H, s), 9.05 (1H, s), 10.07 (1H, s). m/r. (ES+), [M+H]+ = 476.3

.(d).5.-(Me.thy! amino) _: 6-(3 -methylimidazo[4 _a 5 -cJpyridin _: 7_-_yl)_-3 _: £[3 -methy.l -1.-(2,2., 2- trifluoroethyl)pyrazol-4 _: ylJaming}pyrazine-2-carbgxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (130 mg, 0.27 mmol). The resulting mixture was stirred at 80 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 mm x 150 mm, Xselect CSH OBD column, 13 to 24% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5-(methylamino)-6- (3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-t rifluoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxamide (0.099 g, 77% yield) as a yellow solid. 1HNMR (400 MHz, DMSO-d6) d 2.23 (3H, s), 2.98 (3H, s), 4.01 (3H, s), 4.98 (2H, q), 7.25 (1H, br), 7.99 (1H, br s), 8.23 (1H, s), 8.47 (1H, s), 8.74 (1H, s), 9.00 (1H, s), 10.94 (1H, s). The carboxamide NH2 protons were exchanged to baseline, the methylamino NH was a broad singlet, and the methylamino CH3 was a singlet. 19F NMR (376 MHz, DMSO) d -70.40. m/z: (ES+), [M+H]+ = 461.3

Example 209

3-rri-(2.2-Difluoroethvn-3-methyl-pyrazol-4-yllaminol-5-( methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

.(a).. I:!?.,?- Djfl uoroethy 1 ethyl. _: 4-n i tro-pyrazoje. an d J -(¾ 2-di fl uoroethy 1 )- 5 -m ethyl -4- nitrp.-pyrazole

3 -Methyl -4-nitro-lH-pyrazole (3.00 g, 23.6 mmol) was added to a solution of 2,2- difluoroethan-l-ol (2.90 g, 35.4 mmol), DTBAD (6.52 g, 28.3 mmol), and triphenylphosphine (7.43 g, 28.3 mmol) in THF (50 mL) under nitrogen. The resulting mixture was stirred at 25 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 30% EtOAc-petroleum ether as eluent, to afford a 2: 1 mixture of l-(2,2-difluoroethyl)-3-methyl-4-nitro-pyrazole and l-(2,2-difluoroethyl)-5- methyl-4-nitro-pyrazole (2.00 g, 22% yield) as a white solid. This material was further purified by chiral HPLC, using a 3 micron, 3 x 100 mm, CHIRALPAK IC-3 column, using isocratic 5% MeOH-sCCh as eluent, and 0.1% diethylamine as modifier, to afford l-(2,2- difluoroethyl)-3-methyl-4-nitro-pyrazole (0.400 g, 60% yield) as a yellow oil and l-(2,2- difluoroethyl)-5-methyl-4-nitro-lH-pyrazole (0.200 g, 60% yield) as a yellow oil. l-(2,2-difluoroethyl)-3-methyl-4-nitro-pyrazole. 1HNMR (400 MHz, DMSO-d6) d 2.44 (3H, s), 4.66 (2H, td), 6.43 (1H, tt), 8.86 (1H, s). m/z\ (ES+), [M+H]+ = 192.0 l-(2,2-difluoroethyl)-5-methyl-4-nitro-lH-pyrazole. 1H NMR (400 MHz,DMSO-d6) d 2.63 (3H, s), 4.76 (2H, td), 6.42 (1H, tt), 8.31 (1H, s). m/z\ (ES+), [M+H]+ = 192.0 {b).lrX2 _: 2-Difluoroethyl) _: 3-methyl.-pyrazol-4-amine

A mixture of l-(2,2-difluoroethyl)-3-methyl-4-nitro-lH-pyrazole (400 mg, 2.09 mmol) and 10 wt% palladium on carbon (4.22 mg, 2.09 mmol) in MeOH (10 mL) was stirred under a hydrogen atmosphere at 25 °C for 24 hours. The reaction was then filtered through Celite and concentrated to afford l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-amine (0.320 g, 95% yield) as a brown oil. 1H NMR (400 MHz, DMSO) d 2.00 (3H, s), 3.81 (2H, br s), 4.31 (2H, td),

6.20 (1H, tt), 7.00 (1H, s). m/z\ (ES+), [M+H]+ = 162. 1 (c) MethylJ. _: I[I-f2,2-difluprpethy]) _: 3- methyEpyrazol:4 _r ylJaminoJ-5-(methylarninp)-6-(3-methyhmidazo^4 ₁ 5-c] _. pyridiri-7- y _. Upyra?ine-2 _: carbpxylate DIPEA (488 mE, 2.79 mmol) was added to a solution of l-(2,2-difluoroethyl)-3-methyl- pyrazol-4-amine (150 mg, 0.93 mmol) and methyl 3-fluoro-5-(methylamino)-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate (294 mg, 0.93 mmol) in DMSO (10 mL). The resulting mixture was stirred at 100 °C for 24 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, to afford methyl 3-[[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4- yl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxylate (0.150 g, 35% yield) as a yellow solid. 1HNMR (400 MHz, DMSO) d 2.25 (3H, s), 2.94 (3H,

(1H, s), 8.53 (1H, s), 9.05 (1H, s), 10.05 (1H, s). m/z: (ES+), [M+H]+ = 458.2

{dJ _. 3-[y-X2 _J 2-DifluproethylJ-3-methyl-pyrazol-4:ylJaming] _. :5-(methylamino)-6-(3- methyhmMazg[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 3-[[l-(2,2-difluoroethyl)- 3-methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (140 mg, 0.31 mmol). The resulting mixture was stirred at 80 °C for 3 hours. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 x 150 mm, Xselect CSH OBD column, 6 to 25% MeCN- water as eluent, and 0.1% formic acid as modifier, to afford 3-[[l-(2,2-difluoroethyl)-3- methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimidaz o[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (0.059 g, 42% yield) as a yellow solid. 1H NMR (400 MHz,

DMSO) d 2.22 (3H, s), 2.97 (3H, d), 4.01 (3H, s), 4.56 (2H, td), 6.33 (1H, tt), 7.31 (1H, s), 7.70 (1H, s), 8.02 (1H, br q), 8.23 (1H, s), 8.52 (1H, s), 8.72 (1H, s), 9.01 (1H, s), 11.09 (1H, s). 19F NMR (376 MHz, DMSO) d -122.49. m/z\ (ES+), [M+H]+ = 443.2

Example 210

3-rri-(2.2-Difluoroethvn-5-methyl-pyrazol-4-yllaminol-5-( methylamino)-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(aJ.Iri^^-DjfluoroethylJ-ii-methyJ^pyrazoEfl-amine A mixture of l-(2,2-difluoroethyl)-5-methyl-4-nitro-lH-pyrazole (200 mg, 1.05 mmol) and 10 wt% palladium on carbon (22.3 mg, 0.210 mmol) in MeOH (10 mL) was stirred under a hydrogen atmosphere at 25 °C for 24 hours. The reaction was then filtered through Celite and concentrated to afford l-(2,2-difluoroethyl)-5-methyl-pyrazol-4-amine (0.120 g, 71% yield) as a yellow oil. 1H NMR (400 MHz, DMSO-d6) d 2.09 (3H, s), 3.89 (2H, br s), 4.39 (2H, td), 6.22 (1H, tt), 6.97 (1H, s). m/r (ES+), [M+H]+ = 162.1

{b) _. Methyl _. 3 _.-. [Ll-:(-? _J 2-difluoroethyl)-5-inethyl-pyrazpl-4 _: ylJarninp} _: 5-(inethylamino)-6:(3- methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carboxylate l-(2,2-Difluoroethyl)-5-methyl-pyrazol-4-amine (102 mg, 0.63 mmol) was added to a solution of methyl 3-fluoro-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (100 mg, 0.32 mmol) and DIPEA (55 μL, 0.32 mmol) in DMSO (10 mL). The resulting mixture was stirred at 100 °C for 24 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, to afford methyl 3-[[l-(2,2-difluoroethyl)-5-methyl-pyrazol-4- yl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxylate (0.080 g, 55% yield) as a yellow solid. 1HNMR (400 MHz, DMSO) d 2.30 (3H, s), 2.85 (3H, d), 3.82 (3H, s), 4.01 (3H, s), 4.59 (2H, td), 6.35 (1H, tt), 7.78 (1H, br q), 8.01 (1H, s), 8.50 (1H, s), 8.51 (1H, s), 9.05 (1H, s), 9.81 (1H, s). m/r (ES+), [M+H]+ = 458.2 {c).3:^[l-(2,2-Difluproethyl) _: 5-methyl-pyrazpJ. _: 4- _j llamino]-5 _: (methylaminc)) _: 6-(3- methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxamide

7 N Methanolic ammonia (10 mL, 70 mmol) was added to methyl 3-[[l-(2,2-difluoroethyl)-5- methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimidaz o[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate (80 mg, 0.17 mmol). The resulting mixture was stirred at 80 °C for 2 days. The reaction was then concentrated. The resulting residue was purified by reverse phase HPLC, using a 5 micron, 30 x 150 mm, Xselect CSH OBD column, using 8 to 20% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 3-[[l-(2,2-difluoroethyl)- 5-methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimid azo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (0.020 g, 25% yield) as a yellow solid. 1H NMR (DMSO, 400 MHz) d 2.29 (3H, s), 2.89 (3H, d), 4.01 (3H, s), 4.58 (2H, td), 6.35 (1H, tt), 7.29 (1H, br s), 7.68 (1H, br s), 7.89 (1H, br q), 8.06 (1H, s), 8.51 (1H, s), 8.70 (1H, s), 9.01 (1H, s), 10.87 (1H, s). 19F NMR (376 MHz, DMSO) d -122.10. m/r (ES+), [M+H]+ = 443.2 Example 211

3-rri-n-Cvano-l-methyl-ethvn-3-methyl-pyrazol-4-yl1amino1 -5-(methylamino)-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide {4)MethyI _. 6-chlprg-3-[[l _: (l _: cyano-l _. -inethyl-ethyl)-3-methyl:pyrazol:4-yl]amino]-5- {methylaminpjpyrazine-2 _: carbpxylate

DIPEA (1.53 mL, 8.88 mmol) was added to a solution of 2-(4-amino-3-methyl-pyrazol-l-yl)- 2-methyl-propanenitrile (1.35 g, 8.20 mmol) and methyl 6-chloro-3-fluoro-5- (methylamino)pyrazine-2-carboxylate (1.50 g, 6.83 mmol) in DMF (32.6 mL). The resulting mixture was stirred at 100 °C for 18 hours. The reaction was then allowed to cool to room temperature and diluted with DCM and water (40 mL each). The layers were separated and the aqueous layer was extracted three times with DCM (40 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated to afford methyl 6-chloro-3- [[ 1 -( 1 -cyano- 1 -methyl-ethyl)-3 -methyl-pyrazol-4-yl]amino]-5-(methylamino)pyrazine-2- carboxylate as a brown solid, which was carried forward assuming 100% yield. m/z\ (ES+), [M+H]+ = 363.8

{¾ _. Methyl _. 3-[Ll-(l-cyano:l-methyl-ethy)J-3:methyl:pyrazol-4-yl]a mino]:5-(methylaming)-6-

{3:methylimidazg[4 _^ 5 _: c]pyridin-7 _: yl)pyrazine-2-carbgxylate

A suspension of cesium fluoride (2.088 g, 13.74 mmol), PdCh(dppf) (0.561 g, 0.69 mmol), 2- (3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaboro cane (2.02 g, 8.25 mmol), and methyl 6-chloro-3-[[l-(l-cyano-l-methyl-ethyl)-3-methyl-pyrazol-4-y l]amino]-5- (methylamino)pyrazine-2-carboxylate (2.50 g, 6.87 mmol) in water (3.12 mL) and 1,4- dioxane (31.2 mL) was sparged with nitrogen for 10 minutes. The resulting mixture was then stirred at 100 °C for 2 hours. The reaction was then allowd to cool to room temperature and dry-loaded onto celite. The resulting material was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford methyl 3-[[l-(l-cyano-l-methyl-ethyl)-3- methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimidaz o[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate as a brown solid, which was carried forward assuming 100% yield. m/r. (ES+), [M+H]+ = 460.7

{c) _. 3 :HL-( I -Cyano- 1 _: methyl _: ethylJ-3 -methyl-pyrazgl-4:yljaming] _. :5 -(methylamino)-6-(3 - JI ¹ ethyj _.i midazgbd^^cjpyri din- 7 ryjjpy razi ne-2 _: carbgxatTiide 7 N Methanolic ammonia (8.0 mL, 56 mmol) was added to methyl 3-[[l-(l-cyano-l-methyl- ethyl)-3-methyl-pyrazol-4-yl]amino]-5-(methylamino)-6-(3-met hylimidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (450 mg, 0.98 mmol). The resulting mixture was stirred at 80 °C for 24 hours. The reaction was then allowed to cool to room temperature. The resulting solid was filtered, rinsed with methanol (10 mL), and air-dried. Separately, 7 N methanolic ammonia (40 mL, 280 mmol) was added to methyl 3-[[l-(l-cyano-l-methyl-ethyl)-3-methyl- pyrazol-4-yl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c ]pyridin-7-yl)pyrazine-2- carboxylate (3.10 g, 6.73 mmol). The resulting mixture was stirred at 80 °C for 48 hours. The reaction was then allowed to cool to room temperature. The resulting solid was filtered, rinsed with methanol (80 mL), and air-dried. These two solids were combined and dry-loaded onto celite. The resulting material was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford 3-[[l-(l-cyano-l-methyl-ethyl)-3-methyl-pyrazol-4- yl]amino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7 -yl)pyrazine-2-carboxamide (0.354 g, 10% yield over three steps) as a yellow solid. 1HNMR (500MHz, DMSO-d6) 1.97 q), 8.48 (1H, s), 8.54 (1H, s), 8.74 (1H, s), 9.03 (1H, s), 11.14 (1H, s). m/z: (ES+), [M+H]+ =

446.3

Example 212

5-Cvclopropyl-3-r(T.3-dimethylpyrazol-4-vDamino1-6-(3-met hylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

(a) Methyl 6 _: chJprg-5 _: cyploprgpyl:l-I(;iJ. _: dimethylpyrazgJ-4 _: yJ)aming]p.y.razine:2- carbpxylate DIPEA (3.91 mL, 22.4 mmol) was added to a mixture of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (1.035 g, 4.490 mmol) and 1, 3 -dimethylpyrazol -4-amine dihydrochloride (0.991 g, 5.39 mmol) in DMF (14 mL). The resulting mixture was allowed to stir at 100 °C for 2 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0 to 0.2% methanolic ammonia as modifier, to afford methyl 6-chloro-5-cyclopropyl-3-[(l,3-dimethyl- lH-pyrazol-4-yl)amino]pyrazine-2-carboxylate (1.247 g, 86% yield) as an orange solid. 'H NMR (500 MHz, Chloroform-d): d 1.15 - 1.36 (4H, m), 2.29 (3H, s), 2.49 - 2.63 (1H, m),

3.85 (3H, s), 3.99 (3H, s), 7.69 (1H, s), 9.73 (1H, s). m/r. (ES+), [M+H]+ = 322.1

.(b 1 M ethyl .5.-cy cl_op_ropyJ -3 -_[(_[ , 3_-di m ethyjpyrazo j -4-y j )a_m i_no]_-6 _: _(3 _: m_e_thyj_i_m j dazp^S _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate

A mixture of methyl 6-chloro-5-cyclopropyl-3-[(l,3-dimethyl-lH-pyrazol-4- yl)amino]pyrazine-2-carboxylate (1.24 g, 3.85 mmol), 2-(3-methyl-3H-imidazo[4,5-c]pyridin- 7-yl)-l,3,6,2-dioxazaborocane (1.04 g, 4.24 mmol), Pd(dppf)Ch dichloromethane adduct (0.315 g, 0.390 mmol), and cesium fluoride (1.76 g, 11.6 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (17.5 mL) and water (1.75 mL) were added. The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, and 0 to 0.4% methanolic ammonia as modifier. The resulting dark orange solid was stirred in MeOH at 40 °C for 16 hours. The resulting slurry was then allowed to cool to room temperature, filtered, rinsed with diethyl ether, and dried under air to afford methyl 5-cyclopropyl-3-[(l,3-dimethylpyrazol-4- yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-c arboxylate (0.970 g, 60% yield) as a yellow solid. ¾ NMR (500 MHz, DMSO-d6): d 0.88 - 0.97 (2H, m), 1.09 (2H, dt), 1.80 - 1.89 (1H, m), 2.18 (3H, s), 3.79 (3H, s), 3.87 (3H, s), 3.99 (3H, s), 7.85 (1H, s), 8.39 (1H, s), 8.42 (1H, s), 9.05 (1H, s), 9.67 (1H, s). m/z\ (ES+), [M+H]+ = 419.2 (c) 5-Cyclopropyl-3-[(l,3-dimethylpyrazol-4-yl)amino]-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide.

7 N Methanolic ammonia (13 mL, 91 mmol) was added to methyl 5-cyclopropyl-3-[(l,3- dimethyl-pyrazol-4-yl)amino]-6-(3-methylimidazo[4,5-c]pyridi n-7-yl)pyrazine-2-carboxylate (960 mg, 2.29 mmol). The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then allowed to cool to room temperature and left standing for 16 hours. The resulting yellow precipitate was collected by filtration, rinsed with diethyl ether, and dried under vacuum to afford 5-cyclopropyl-3-[(l,3-dimethylpyrazol-4- yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-c arboxamide (911 mg, 98% yield). ¾ NMR (500 MHz, DMSO-d6): d 0.86 - 0.97 (2H, m), 1.06 - 1.15 (2H, m), 1.82 - 1.95 (1H, m), 2.17 (3H, s), 3.78 (3H, s), 3.99 (3H, s), 7.76 (1H, br s), 7.85 (1H, s), 8.02 (1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.03 (1H, s), 10.81 (1H, s). m/r. (ES+), [M+H]+ = 404.2

Examples 213 and 214

5-Cvclopropyl-6-(3-methylimidazor4.5-clpyridin-7-vD-3-IT3 -methyl-l -(2.2.2- trifluoroethvDpyrazol-4-vnaminolpyrazine-2-carboxamide and 5-cvclopropyl-6-(3- methylimidazor4.5-clpyridin-7-vD-3-IT5-methyl-l-(2.2.2-trifl uoroethvDpyrazol-4- yllaminolpyrazine-2-carboxamide

{aX^rMethyMrnitro _j J-Q^^trifluproethyl^jx^ole.and S-methyl-d-nitro-l-Q^?- trifluoroethyljpyrazole

Potassium carbonate (2.18 g, 15.7 mmol) was added to a solution of l,l,l-trifluoro-2-iodo- ethane (1.15 mL, 11.8 mmol) and 3-methyl-4-nitro-lH-pyrazole (1.00 g, 7.87 mmol) in DMF (18.5 mL). The resulting mixture was stirred at 100 °C for 4 hours. The reaction was then allowed to cool to room temperature and diluted with EtOAc and water (50 mL each). The layers were separated and the aqueous layer was extracted three times with EtOAc (50 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 40% EtOAc-hexanes as eluent, to afford a 3:1 mixture of 3-methyl-4-nitro-l-(2,2,2- trifluoroethyl)pyrazole and 5-methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole (1.03 g, 63% yield) as a brown oil.

3-methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole: 1HNMR (500MHz, DMSO-d6) 2.44 (3H, s), 5.17 (2H, q), 8.92 (1H, s) m/z\ (ES+), [M+H]+ = 209.8. 5-methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole: 1H NMR (500MHz, DMSO-d6) 2.65 (3H, s), 5.30 (2H, q), 8.35 (1H, s) m/z\ (ES+), [M+H]+ = 209.8. {¾ _. 3 _r Methyl _: l _r X2 ₅ 2 ₃ 2-trifluoroetih[yl)pyrazpl:4-amine _. ^d _. S-methy _. l-l-Q, _. ?^?- trifluorgethyl)pyrazgl-4 _: amine

Iron powder (1.10 g, 19.7 mmol) was added to a suspension of ammonium chloride (1.05 g, 19.7 mmol) and a 3:1 mixture of 3-methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole and 5- methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole (1.03 g, 4.93 mmol) in water (12.3 mL) and ethanol (12.3 mL). The resulting mixture was stirred at 60 °C for 1 hour. The reaction was then allowed to cool to room temperature and diluted with DCM (5 mL). The aqueous layer was extracted twice with DCM (5 mL). The combined organics layers were dried over sodium sulfate, filtered, and concentrated to afford a 3: 1 mixture of 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazol -4-amine and 5-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-amine as a brown oil, which was carried forward assuming 100% yield. m/z\ (ES+), [M+H]+ = 179.9 £cj. Methyl. (i-chJgrg-S-cyclgprgpyLj-fp-methyJ-l ^^^^-triflugrpethyJJpyrazgl-fl- ylJ¾rning}pyrazine-2-carbgxylate and methyl _. 6-chlprg-5-cyclgprppy _. l _: 3 _. -[[5-methyl-l-(2,2,2- trifluorgethyl)pyrazgl-4 _: ylJaming}pyrazine-2-carbgxylate

DIPEA (888 μL, 5.15 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (792 mg, 3.44 mmol), and a 3: 1 mixture of 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazol -4-amine and 5-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-amine (800 mg, 4.47 mmol) in 1,4-dioxane (21.4 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then allowed to cool to room temperature and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford a 3:1 mixture of methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate and methyl 6-chloro-5-cyclopropyl- 3-[[5-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyra zine-2-carboxylate (1.20 g, 90% yield) as a brown solid, m/z: (ES+), [M+H]+ = 390.1.

£d).Methyl 5_-cydgp.rgpyJ-6-(3 _: methyJ_im_i_dazgb4 ₁ 5 _: _c]pyridi.n-7 _: yJJ-3_-[b3 _: nie.thyJ_ _: _l_-(2 _J 2,_2- trifluorgethy l)py razgl -4 _: y ljaminojpy ;razine-2-carb gxy 1 ate and methyl _. 5 : _. cy clgprgpy 1 _-6 _: £3 _: methylimidazgb4 ₁ 5 _: c]pyridin-7 _: ylJ-3-[b5 _: methyl _: l.-£2 _: 2,2-triflugrpethyl)pyrazpl _: 4- ylJ¾rning}pyrazine-2-carbgxylate

A suspension of a 3:1 mixture of methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate and methyl 6-chloro-5-cyclopropyl- 3-[[5-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyra zine-2-carboxylate (1.20 g, 3.08 mmol), cesium fluoride (935 mg, 6.16 mmol), PdCb(dppf) (250 mg, 0.31 mmol), and 2-(3- methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaborocan e (905 mg, 3.69 mmol) in 1,4- dioxane (28 mL) and water (2.8 mL) was sparged with nitrogen for 10 minutes. The resulting mixture was stirred at 90 °C for 1 hour. The reaction was then allowed to room temperature and diluted with DCM and water (40 mL each). The layers were separated and the aqueous layer was extracted three times with DCM (40 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, to afford methyl 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-met hyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (250 mg, 17% yield) as a brown solid, m z: (ES-), [M-H]- = 485.2

(eJ _. iirCyclopropyl-ri _T fj-iriethyJirnidazofd^-cJpyridin-y _.T ylj _TJ -tp-rnethyl-l:^?^- trifluorgethyl)pyrazgl-4 _: ylJaminp}pyrazine-2-carbgxamide and 5-cycloprp _. pyl: _. 6-(3- methyhmidazgP_P_ _: c]pyridin _: 7 _: ylJ _: 3-[b5 _: methyl _: l _r X2 _: 2,2-triflugrpethy_l)pyrazpl _: 4- y]j4 _. illing2pyrazine-2-carbgxamide

7 N Methanolic ammonia (5.0 mL, 35 mmol) was added to a 3:1 mixture of methyl 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-met hyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (250 mg, 0.534 mmol). The resulting mixture was stirred at 60 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent. The resulting material was further purified by preparative SFC, using a 5 micron, 21 mm x 250 mm Chiralpak ID column, isocratic 30% MeOH-sC0 ₂ as eluent, and 0.2% ammonium hydroxide as modifier, to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide (140 mg, 56% yield) as a yellow solid and 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-m ethyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide (44.8 mg, 18% yield) as a yellow solid. 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide: 1H NMR (500 MHz, DMSO-d6) d 0.86-0.97 (2H, m), 1.04-1.16 (2H, m), 1.85-1.95 (1H, m), 2.22 (3H, s), 3.99 (3H, s), 5.08 (2H, q), 7.80 (1H, br s), 7.98-8.11 (2H, m), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.90 (1H, s). m/r. (ES-), [M-H]- = 470.2

5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 5-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide: 1H NMR (500MHz, DMSO-d6) d 0.76-0.90 (2H, m), 0.92-1.04 (2H, m), 1.79-1.93 (1H, m), 2.27 (3H, s), 3.98 (3H, s), 5.09 (2H, q), 7.76 (1H, br s), 7.84 (1H, s), 8.02 (1H, br s), 8.42 (1H, s), 8.50 (1H, s), 9.02 (1H, s), 10.56 (1H, s). m/z\ (ES-), [M-H]- = 470.2

Example 213, alternative preparation

5-Cvclopropyl-6-(3-methylimidazor4.5-clpyri din-7-vD-3-rr3-methyl- 1 -(2.2.2- trifluoroethvDpyrazol-4-yllaminolpyrazine-2-carboxamide

_. (aJ _.J rMethy _. l-d _T nitro- l-^^ _T trifluoroethylJpyrazole and S-iTiethyl-d^nitro-l -i?,?,?- trifluproethyljpyrazole l,l,l-Trifluoro-2-iodo-ethane (24.0 mL, 244 mmol) was added to a mixture of 3-methyl-4- nitro-lH-pyrazole (23.7 g, 186 mmol) and cesium carbonate (72.9 g, 224 mmol) in DMF (200 mL). The resulting mixture was stirred at 80 °C for 2.5 hours, then at 100 °C for 2.5 hours. Additional l,l,l-trifluoro-2-iodoethane (7.0 mL, 71 mmol) was added and the resulting mixture was stirred at 110 °C for 90 minutes, then at room temperature for 84 hours. The reaction was then filtered through a silica pad, rinsing copiously with EtOAc. The resulting filtrate was concentrated to a volume of ~80 mL and then diluted with saturated aqueous ammonium chloride (300 mL) and EtOAc (100 mL). The layers were separated and the aqueous layer was extracted three times with EtOAc (50 mL each). The combined organics were washed twice with 5% aqueous LiCl (100 mL each), then dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel chromatography, using 0-40% EtOAc-hexanes as eluent, to afford a yellow solid. This material was further purified by SFC, using a 30 mm x 250 mm, 5 micron, IG column, isocratic 10% MeOH/sC0 ₂ as eluent, and 0.2% ammonium hydroxide as modifier, to afford 3-methyl-4-nitro-l-(2,2,2- trifluoroethyl)pyrazole (13.93 g, 36% yield) and 55-methyl-4-nitro-l-(2,2,2- trifluoroethyl)pyrazole (5.77 g, 15% yield), each as a beige solid.

3-Methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole: 1H NMR (500 MHz, DMSO-d6) d 2.44 (3H, s), 5.17 (2H, q), 8.92 (1H, s). m/z\ (ES+), [M+H] ⁺ = 210.1

5-Methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole: 1H NMR (500 MHz, DMSO-d6) d 2.65 (3H, s), 5.31 (2H, q), 8.36 (1H, s). m/z\ (ES+), [M+H] ⁺ = 210.1 (bi.SrMethyl-l^^^^trifluorpethylJpyrazpEfl-amine

A mixture of 3-methyl-4-nitro-l-(2,2,2-trifluoroethyl)pyrazole (13.9 g, 66.5 mmol) and 10 wt% palladium on carbon (2.55 g, 2.40 mmol) in MeOH (133 mL) was stirred at room temperature for 3 hours under a hydrogen atmosphere. Acetic acid (1.0 mL, 18 mmol) and additional 10 wt% palladium on carbon (1.0 g, 0.94 mmol) were added and the hydrogen atmosphere was refreshed. The resulting mixture was stirred at room temperature for 21 hours. The reaction was then filtered through Celite, rinsing copiously with DCM. The filtrate was concentrated to afford 3 -methyl- 1 -(2, 2, 2-trifluoroethyl)pyrazol -4-amine (12.6 g, quantitative) as a dark purple oil. 1H NMR (500 MHz, CHLOROFORM-d) d 2.19 (3H, s), 3.30 (2H, br s), 4.52 (2H, q), 7.04 (1H, s). 19F NMR (471 MHz, CHLOROFORM-d) -72.00. m/z: (ES+), [M+H] ⁺ = 180.0

{c)MethyL6:chlprg-5-cjpjpprppyF3_-[[3-methyl-l-(2,2,2-tri fluoroethyl)pyrazol-4- ylJa _. ininoJ _. pyrazine-^-carbgxylate

DIPEA (27.2 mL, 156 mmol) was added to a solution of 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazol -4-amine (11.9 g, 66.6 mmol) and methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (12.0 g, 52.0 mmol) in DMF (200 mL). The resulting mixture was stirred at 100 °C for 3 hours under nitrogen. The reaction was then allowed to cool to room temperature and concentrated. The resulting residue was taken up in MeOH (100 mL) and stirred at 50 °C for 2 hours. The resulting slurry was allowed to cool to room temperature, then filtered. The filter cake was rinsed with minimal MeOH and set aside. The filtrate was concentrated, and the slurrying/filtration procedure was carried out twice more. The filter cakes from these three operations were combined to afford methyl 6-chloro-5-cyclopropyl-3- [[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazi ne-2-carboxylate (8.72 g, 43% yield) as a yellow-orange solid. 1H NMR (500 MHz, CHLOROFORM-d) d 1.18 - 1.23 (2H, m), 1.23 - 1.30 (2H, m), 2.34 (3H, s), 2.53 - 2.63 (1H, m), 4.01 (3H, s), 4.65 (2H, q), 7.92 (1H, s), 9.83 (1H, s). 19F NMR (471 MHz, CHLOROFORM-d) -71.86. m/z\ (ES+), [M+H] ⁺

= 390.1

£dJ.Methyl 5_-cy_dop_rqpyJ-6-(3 _: _methyJ).midazoI4 ₁ 5 _: _c]pyri_d_i_n-7 _: yJJ-3_-[£3 _: m_ethyL_l_-(2 _J _2,_2- trifluorgethyl)pyrazgl-4 _: ylJaminp].pyrazine-2-carbgxylate Methyl 6-chloro-5-cyclopropyl-3-[[3 -methyl- 1 -(2,2, 2-trifluoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (8.60 g, 22.1 mmol), 2-(3-methylimidazo[4,5-c]pyridin-7- yl)-l,3,6,2-dioxazaborocane (8.14 g, 33.1 mmol), Pd(dppf)C12 dichloromethane adduct (1.80 g, 2.21 mmol), and cesium fluoride (10.1 g, 66.2 mol) were combined. 1,4-Dioxane (100 mL) and water (10 mL) were added and the resulting mixture was stirred as the reaction vessel was evacuated and backfilled with nitrogen five times. The resulting mixture was then stirred at 80 °C for 3 hours. The reaction was then allowed to cool to room temperature and concentrated. The resulting residue was taken up in 4: 1 MeOH/water and stirred at 50 °C for 2 hours. The resulting slurry was allowed to cool to room temperature and filtered, rinsing sequentially with water, MeOH, and diethyl ether. The filter cake was set aside. The filtrate was concentrated. The resulting residue was taken up in 5: 1 DCM/MeOH and filtered through Celite, rinsing copiously with DCM. The Celite-containing filter cake was discarded. The resulting filtrate was concentrated, and the resulting residue was purified by silica gel chromatography, using 0-10% MeOH-DCM as eluent, and 0-0.2% methanolic ammonia as modifier, to afford a dark yellow foam. This material was taken up in 5: 1 MeOH/di ethyl ether and stirred at 50 °C for 1 hour. The resulting suspension was allowed to cool to room temperature and filtered, rinsing sparingly with diethyl ether. The filter cake was set aside. This slurrying/filtration/concentration process was repeated four additional times. The six filter cakes were combined to afford methyl 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin- 7-yl)-3-[[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]amin o]pyrazine-2-carboxylate (9.26 g, 86% yield) as a yellow solid. 1H NMR (500 MHz, CHLOROFORM-d) d 1.02 (2H, br dd), 1.25 - 1.30 (2H, m), 1.97 - 2.05 (1H, m), 2.39 (3H, s), 4.00 (3H, s), 4.01 (3H, s), 4.66 (2H, q), 8.01 (1H, s), 8.06 (1H, s), 8.68 (1H, s), 8.92 (1H, s), 9.98 (1H, s). 19F NMR (471 MHz, CHLOROFORM-d) -71.86. m z: (ES+), [M+H] ⁺ = 487.2

_. (e) _.. 5:Cycloprgpyl-6 _T (3-methyJirnidazg[4,5-c]pyridin-7:y]):3-[[3-rriethyJ-l _r (2,2,2- triflugrgethyl)pyrazgl-4 _: ylJaming].pyrazine-2-carbgxamide 7 N Methanolic ammonia (106 mL, 740 mmol) was added to methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate (9.00 g, 18.5 mmol). The resulting suspension was stirred at 100 °C for 2 hours in a sealed pressure flask. The reaction was then allowed to cool to room temperature, then cooled to 0 °C. The resulting precipitate was collected by filtration, rinsing with cold MeOH and copious diethyl ether. The filter cake was set aside. The filtrate was concentrated. The resulting residue was taken up in 4: 1 MeOH/di ethyl ether and stirred at 0 °C for 30 minutes. The resulting precipitate was collected by filtration, rinsing copiously with diethyl ether. The filter cake was set aside. This slurrying/filtration/concentration procedure was carried out twice more. The four filter cakes were then taken up together in 3 : 1 MeOH/di ethyl ether and stirred at 50 °C for 16 hours. The resulting slurry was allowed to cool to room temperature, then cooled to 0 °C, then filtered, rinsing with cold MeOH and diethyl ether. The resulting filter cake was dried under vacuum to afford 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-l-(2,2,2-trif luoroethyl)pyrazol-4- yl]amino]pyrazine-2-carboxamide (7.66 g, 88% yield) as a bright yellow solid. 1H NMR (500 MHz, DMSO-d6) d 0.91 (2H, br dd), 1.11 (2H, br s), 1.85 - 1.93 (1H, m), 2.22 (3H, s), 3.99 (3H, s), 5.09 (2H, q), 7.82 (1H, br s), 8.05 (1H, s), 8.08 (1H, br s), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.92 (1H, s). 19F NMR (471 MHz, DMSO-d6) -70.46 (IF, s). m/r. (ES+), [M+H] ⁺ = 472.2

The solid residue was found to be crystalline by XRPD (form A) and a typical diffractogram is displayed in Figure 11. Characteristic peak positions are listed below in Tables 11 and 12.

Table 11. Five peaks characteristic for Example 213, form A

Table 12. Peaks characteristic for Example 213, form A

Form A was further analyzed by thermal techniques. DSC analysis shows several thermal events from 200 °C to 300 °C. Form A has an exothermic event with an onset at 222 °C and a peak at 226 °C, and then an endothermic with an onset at 254 °C and a peak at 258 °C, followed by an exothermic event with an onset at 259 °C and a peak at 260 °C. The final material has a melting/decomposition temperature with an onset at 281 °C and a peak at 283 °C. TGA indicated that Form A exhibits a mass loss of about 1.3 % upon heating from about 25 °C to about 150 °C. A representative DSC/TGA thermogram of Form A is shown in Figure 12.

5-6 mg of Example 213, Form A was suspended in 0.5 ml of EtOH (or ACN), and the yellow slurry was stirred at the room temperature for 1 day. 4-5 mg of yellow solid of Form B was obtained after filtration and air-dried.

The solid residue was found to be crystalline by XRPD (form B) and a typical diffractogram is displayed in Figure 13. Characteristic peak positions are listed below in Tables 13 and 14.

Table 13. Five peaks characteristic for Example 213, form B

Table 14. Peaks characteristic for Example 213, form B

Form A was further analyzed by thermal techniques. DSC analysis indicated that Form B has a melting/decomposition temperature with an onset at 282 °C and a peak at 283 °C. TGA indicated that Form B exhibits a mass loss of about 0.1 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form B is shown in Figure 14.

20 mg of Example 213, Form B was suspended in 1.0 ml of H20 and 0.4 ml of EtOH. The yellow slurry was stirred at the room temperature for 3 days. 17 mg of yellow solid of Form C was obtained after filtration and air-dried. The solid residue was found to be crystalline by XRPD (form C) and a typical diffractogram is displayed in Figure 15. Characteristic peak positions are listed below in Tables 15 and 16.

Table 15. Five peaks characteristic for Example 213, form C

Table 16. Peaks characteristic for Example 213, form C

Form C was further analyzed by thermal techniques. DSC analysis indicated that Form C starts to de-solvate with an onset at 66 °C and a peak at 93 °C, the de-hydrated form then has an endothermic with an onset at 258 °C and a peak at 260 °C, followed by an exothermic event with a peak at 263 °C. The final material has a melting/decomposition temperature with an onset at 281 °C and a peak at 283 °C. TGA indicated that Form C exhibits a mass loss of about 4.0 % upon heating from about 25 °C to about 100 °C. A representative DSC/TGA thermogram of Form C is shown in Figure 16. 2-5 mg of Example 213, Form C was placed to a DSC pan and heated to 150°C at a rate of

10/min, then cooled down to the room temperature. The solid residue was found to be crystalline by XRPD (form D) and a typical diffractogram is displayed in Figure 17. Characteristic peak positions are listed below in Tables 17 and 18. Table 17. Five peaks characteristic for Example 213, form D

Table 18. Peaks characteristic for Example 213, form D

24 mg of Example 213 was suspended in 1.0 ml of MeOH. 55 mΐ of IN HC1 aqueous solution was added to the suspension, the solid was partially dissolved. After 20 minutes, extra 55 mΐ of IN HC1 aqueous solution was added, yellow solid started to precipitate and formed a wet cake. 1.0 ml of EtOH was added and the slurry was stirred at the room temperature for 5 days. The yellow suspension was filtrated and air-dried. 25 mg of yellow solid of HC1 salt of Form A was obtained. The solid residue was found to be crystalline by XRPD (Form A, HC1 salt) and a typical diffractogram is displayed in Figure 18. Characteristic peak positions are listed below in Tables 19 and 20. Table 19. Five peaks characteristic for Example 213, Form A, HC1 salt

Table 20. Peaks characteristic for Example 213, Form A, HC1 salt

Form A, HC1 salt was further analyzed by thermal techniques. DSC analysis indicated that Form A, HC1 salt starts to de-solvate with an onset at 96 °C and a peak at 125 °C. The de hydrated solid starts to decompose at about 200 °C. TGA indicated that Form A, HC1 salt exhibits a mass loss of about 5.7 % upon heating from about 25 °C to about 150 °C. A representative DSC/TGA thermogram of Form A, HC1 salt is shown in Figure 19.

196 mg of Example 213 was suspended in 6.0 ml of EtOH. 0.44 ml of 1NHC1 aqueous solution was added to the suspension. The slurry was stirred at the room temperature for 1 day and then heated to 75°C and stirred at 75°C for 1 hour. The yellow suspension was cooled down and filtered. The yellow solid was dried at 50°C in vacuum for 1 hour. 186 mg of yellow solid of HC1 salt of Form B was obtained. The solid residue was found to be crystalline by XRPD (Form B, HC1 salt) and a typical diffractogram is displayed in Figure 20. Characteristic peak positions are listed below in Tables 21 and 22. Table 21. Five peaks characteristic for Example 213, Form B, HC1 salt

Table 22. Peaks characteristic for Example 213, Form B, HC1 salt

Form B, HC1 salt was further analyzed by thermal techniques. DSC analysis indicated that Form B, HC1 salt starts to de-solvate with an onset at 84 °C and a peak at 117 °C. The de hydrated solid starts to decompose at about 200 °C. TGA indicated that Form B, HC1 salt exhibits a mass loss of about 3.7 % upon heating from about 25 °C to about 120 °C. A representative DSC/TGA thermogram of Form B, HC1 salt is shown in Figure 21.

191 mg of Example 213 was suspended in 4.0 ml of EtOH. 0.44 ml of IN methane sulfonic acid aqueous solution was added to the suspension, a wet cake was formed in about 15 minutes 2.0 ml of EtOH was added and the resulting slurry was stirred at the room temperature for 1 day. The solid was isolated and dried in air. 208 mg of yellow solid of Form A, methane sulfonic acid was obtained. The solid residue was found to be crystalline by XRPD (Form A, methane sulfonic acid salt) and a typical diffractogram is displayed in Figure 22. Characteristic peak positions are listed below in Tables 23 and 24.

Table 23. Five peaks characteristic for Example 213, Form A, methane sulfonic acid salt

Table 24. Peaks characteristic for Example 213, Form A, methane sulfonic acid salt

Form A, methane sulfonic acid salt was further analyzed by thermal techniques. DSC analysis indicated that a broad endothermic de-solvent from about 25 °C to about 120 °C. the de hydrated solid has an endothermic with an onset at 244 °C and a peak at 245 °C, followed by an exothermic event with an onset at 246 °C and a peak at 247 °C. The final material has a melting/decomposition temperature with an onset at 285 °C and a peak at 286 °C. TGA indicated that Form A, methane sulfonic acid salt exhibits a mass loss of about 3.0 % upon heating from about 25 °C to about 120 °C. A representative DSC/TGA thermogram of Form A, methane sulfonic acid salt is shown in Figure 23.

2-5 mg of Form A, methane sulfonic acid salt was placed to a DSC pan and heated to 275°C at a rate of 10/min, then cooled down to the room temperature. A yellow solid was obtained. The solid residue was found to be crystalline by XRPD (Form B, methane sulfonic acid salt) and a typical diffractogram is displayed in Figure 24. Characteristic peak positions are listed below in Tables 25 and 26.

Table 25. Five peaks characteristic for Example 213, Form B, methane sulfonic acid salt

Table 26. Peaks characteristic for Example 213, Form B, methane sulfonic acid salt

197 mg of Example 213 was suspended in 6.0 ml of EtOH. 0.44 ml of IN methane sulfonic acid aqueous solution was added to the suspension. The slurry was stirred at the room temperature for 1 day. The slurry was heated to 75°C and stirred at 75°C for 1 hour. The resulting suspension was cooled down to the room temperature and filtered. The resulting solid is dried at 50°C in vacuum for 1 hour. 203 mg was obtained. The solid residue was found to be crystalline by XRPD (Form C, methane sulfonic acid salt) and a typical diffractogram is displayed in Figure 25. Characteristic peak positions are listed below in Tables 27 and 28. Table 27. Five peaks characteristic for Example 213, Form C, methane sulfonic acid salt

Table 28. Peaks characteristic for Example 213, Form C, methane sulfonic acid salt

Form C, methane sulfonic acid salt was further analyzed by thermal techniques. DSC analysis indicated that Form C, methane sulfonic acid salt starts to de-solvate with an onset at 82 °C and a peak at 121 °C. The de-solvated form has a melting/decomposition temperature with an onset at 288 °C and a peak at 290 °C. TGA indicated that Form C, methane sulfonic acid salt exhibits a mass loss of about 4.2 % upon heating from about 25 °C to about 120 °C. A representative DSC/TGA thermogram of Form C, methane sulfonic acid salt is shown in

Figure 26.

Alternative preparation of methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate

_. 4) _. Ethyl N-(2, 2 2-trifluqroethyl amino)carb am ate

Pyridine (116.5 g, 1473 mmol) was added to a mixture of 70 wt% aqueous 2,2,2- trifluoroethylhydrazine (80 g, 490 mmol) in 2-methyltetrahydrofuran (880 mL) at 0 °C. DMAP (4.30 g, 24.5 mmol) was added. Ethyl chloroformate (58.6 g, 540 mmol) was added dropwise and the ice bath was removed. The resulting mixture was stirred at room temperature for 20 h. The reaction was then poured into water (200 mL) and stirred at room temperature for 30 min. The layers were separated and the aqueous layer was extracted twice with EtOAc (400 mL each). The combined organics were washed twice with brine (400 mL each), dried over sodium sulfate, filtered, and concentrated. The resulting solid was triturated in ice-cold pentane (450 mL), then filtered, rinsing with ice-cold pentane (50 mL). The resulting filter cake was dried under vacuum at 40 °C, to afford ethyl N-( 2,2,2- trifluoroethylamino)carbamate (74.9 g, 402 mmol, 82% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) 5 1.16 (3H, t), 3.39 (2H, qd), 4.02 (2H, q), 5.33 (1H, q), 8.74 (1H, s). l?) _. 3 _. :Methyl_-ri_ _: (2 _^ 22 _: trifluprgethyl)pyrazgle-4-carbpxylic acid

Ethyl 2-(ethoxymethylene)-3-oxo-butanoate (77.7 g, 417 mmol) was added to a solution of ethyl /V-(2,2,2-trifluoroethylamino)carbamate (74.0 g, 398 mmol) and AcOH (2.40 g, 39.8 mmol) in EtOH (296 mL). The resulting mixture was stirred at 80 °C for 18 h. 2M aqueous NaOH (596 mL, 1190 mmol) was added dropwise at 80 °C. The resulting mixture was stirred at 80 °C for 4 h. The reaction was then cooled to room temperature, diluted with water (1 L), and washed three times with MTBE (500 mL each). The aqueous layer was acidified to pH 3 with 2 M aqueous HC1, then extracted three times with EtOAc (500 mL each). This second batch of combined organics was washed with brine (500 mL), dried over sodium sulfate, filtered, and concentrated. The resulting solid was suspended in heptane (500 mL) and the resulting suspension was stirred at 50 °C for 1 h. This mixture was then stirred at room temperature for 16 h, then filtered. The resulting filter cake was washed with heptane, then dried under vacuum at 40 °C, to afford 3-methyl-l-(2,2,2-trifluoroethyl)pyrazole-4-carboxylic acid (68.6 g, 330 mmol, 83% yield) as a beige solid. ¾ NMR (400 MHz, DMSO-d6) d 2.34 (3H, s), 5.10 (2H, q), 8.27 (1H, s), 12.41 (1H, s). m/z (ES+), [M+H] ⁺ = 209.0 c ) Benzyl 7V-I5 -methyl- 1 -(z,z,z-tntluoroethyl Jp r_azoi-4- l^carba ate DPPA (111.6 g, 405.4 mmol) was added to a solution of 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazole-4-carboxylic acid and triethylamine (44.0 g, 435 mmol) in toluene (686 mL). The resulting mixture was stirred at room temperature for 3 h. Benzyl alcohol (130.8 g, 1210 mmol) was added and the resulting mixture was stirred at 100 °C for 3 h. The reaction was then allowed to cool to room temperature and quenched with saturated aqueous sodium bicarbonate (1 L). The layers were separated, and the organic layer was washed three times with saturated aqueous sodium bicarbonate (500 mL each). The organic layer was then dried over sodium sulfate, filtered, and concentrated. The resulting solid was stirred in petroleum ether (1 L) for 1 h. The resulting suspension was filtered. The filter cake was washed with petroleum ether (100 mL), then dried under vacuum at 40 °C, to afford benzyl N- [3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]carbamate (85.6 g, 273 mmol, 83% yield) as a white solid. 1H (400 MHz, DMSO-d6) d 2.09 (3H, s), 4.96 (2H, q), 5.12 (2H, s), 7.30-7.43 (5H, m), 7.83 (1H, s), 9.15 (1H, s). m/z (ES+), [M+H] ⁺ = 314.1 d) 3 -Methyl - 1 -(2,2,2-trifl uoroethyJ)pyrazol_-4 _: _am_i_ne

A mixture of benzyl A ^f -[3 -methyl -1 -(2,2,2-trifluoroethyl)pyrazol-4-yl]carbamate (85.6 g, 273 mmol) and 20 wt% palladium on carbon (14.5 g, 137 mmol) in MeOH (770 mL) was stirred under a hydrogen atmosphere at room temperature for 16 h. The reaction was then filtered through Celite. The filtrate was concentrated to afford 3-methyl-l -(2,2,2- trifluoroethyl)pyrazol -4-amine (48.4 g, 270 mmol, 99% yield) as a light tan solid. 1H (400 MHz, DMSO-d6) d 2.01 (3H, s), 3.78 (2H, s), 4.79 (2H, q), 7.03 (1H, s). m/z (ES+), [M+H] ⁺ = 180.2 e) Methyl 5-cmoro-6-cyclopropyl-2-oxo-lH-p_yrazme _: 3-carboxylate Sodium nitrite (78.2 g, 1130 mmol) in water (1.3 L) was added dropwise into a solution of methyl 3-amino-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate (129 g, 567 mmol) and 80% aqueous sulfuric acid (1.29 L) in MeCN (1.3 L). The resulting mixture was stirred at room temperature for 1 h. The reaction was then poured into ice water (1.3 L). The resulting slurry was filtered and rinsed three times with water (650 mL each). The resulting filter cake was dried under vacuum at 40 °C to afford methyl 5-chloro-6-cyclopropyl-2-oxo-lH-pyrazine-3- carboxylate (117 g, 512 mmol, 90% yield) as a light yellow solid. 1H (400 MHz, DMSO-d6) d 1.08 (2H, dt), 1.19 (2H, dt), 2.42 (1H, tt), 3.84 (3H, s). m/r (ES+), [M+H] ⁺ = 229.0 i) _. MethyJ _. 6-cMpro-5:cyclgpropyl-3-(trifluprgmethylsulfgnyloxy _. )pyrazine-2:carboxylate Triflic anhydride (131.7 g, 466.7 mmol) was added dropwise to a solution of methyl 5-chloro- 6-cyclopropyl-2-oxo-lH-pyrazine-3-carboxylate (97.0 g, 424 mmol) and DIPEA (109.7 g, 848.5 mmol) at 0 °C in DCM (1.4 L). The resulting mixture was stirred at 0 °C for 30 min. The reaction was then poured into heptane (1.45 L) and stirred at room temperature for 30 min. The resulting slurry was filtered and washed with heptane (500 mL). The filtrate was washed three times with water (700 mL each) and once with brine (700 mL). The organic phase was then dried over sodium sulfate, filtered, and concentrated to afford methyl 6- chloro-5-cyclopropyl-3-(trifluoromethylsulfonyloxy)pyrazine- 2-carboxylate (142 g, 88 wt%, 82% yield) as a yellow solid. 1H (400 MHz, DMSO-d6) d 1.10-1.03 (2H, m), 1.39 (2H, dq), 2.61 (1H, tt), 3.49 (3H, s). m/r (ES+), [M+H] ⁺ = 360.9 g) _. Methxl _. 6rchlgrg _r 5-cyclpprgpyJ _T 3-[[3-rnethyl-l _: (2 ₁ 2,2 _r tritlugrgethyJ)pyrazgJ-4- ylJ¾tning}pyrazine-2-carbgxylate

DIPEA (93.3 g, 722 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- (trifluoromethylsulfonyloxy)pyrazine-2-carboxylate (86.8 g, 212 mmol (88wt%)) and 3- methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-amine (47.0 g, 262 mmol) in DMF (1.2 L). The resulting mixture was stirred at 100 °C for 5 h. The reaction was then cooled to room temperature, then poured into water (2.4 L) and stirred for 30 min. The resulting slurry was filtered, and the filter cake was rinsed three times with water (500 mL each). The filter cake was dried under vacuum at 40 °C to afford methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxyl ate (90.1 g, 88 wt%, 203 mmol, 96% yield as a light yellow solid. 1H (400 MHz, DMSO-d6) d 1.23-1.16 (2H, m), 1.25 (2H, dt), 2.33 (3H, s), 2.58 (1H, tt), 4.01 (3H, s), 4.64 (2H, q), 7.91 (1H, s), 9.82 (1H, s). m/r (ES+), [M+H] ⁺ = 390.1

Alternative preparation of methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate a) _. tert _: Butyl N:[3-methyl _: l _: 0_,2,2 _r triflugrgethyl)pyrazgl-4_-yl]carbamate Triethylamine (93.0 mL, 664 mmol) was added to a solution of 3 -methyl- 1 -(2,2,2- trifluoroethyl)pyrazole-4-carboxylic acid (39.5 g, 190 mmol) in toluene (400 mL) and tert- butanol (72.6 mL, 759 mmol). The resulting mixture was stirred at 90 °C for 45 min. A solution of DPP A (42.8 mL, 199 mmol) in toluene (100 mL) was added at 1 mL/min to the reaction mixture at 90 °C. Following the addition, the resulting mixture was stirred at 90 °C for 50 min, then at 25 °C for 30 min. The reaction was then quenched with saturated aqueous sodium bicarbonate (400 mL). The layers were then separated and the organic layer was washed once with aqueous sodium bicarbonate (200 mL), once with a mixture of saturated aqueous potassium bi sulfate (200 mL) and water (400 mL), and once with 30% brine (20 mL). The organic layer was then dried over sodium sulfate, filtered through Celite, and concentrated to remove 70% of the toluene. The resulting mixture was heated to 60 °C, seeded with 10 mg of tert-butyl N-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]carbamate, and heptane (360 mL) was added dropwise. The resulting suspension was cooled to 20 °C over 1 h, then filtered, rinsing with 3:1 heptane/toluene (160 mL). The resulting filter cake was dried under air for 5 min and then dried under vacuum for 3 d, to afford tert-butyl N-[3- methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]carbamate (31.7 g, 60% yield) as a tan solid. 1H (400 MHz, DMSO-d6) d 1.45 (9H, s), 2.08 (3H, s), 4.94 (2H, q), 7.79 (1H, s), 8.72 (1H, s). m/z: (ES+), [M+H] ⁺ = 280.1 b) 3 _. :MethyL- _. L _T i2 _.,. 2 ₁ 2:tritluoroethyJ)pyrazol-4 _: amine tosyJate

4-methylbenzenesulfonic acid hydrate (25.3 g, 133 mmol) was added to a solution of tert- butyl N-[3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4-yl]carbamate (31.0 g, 111 mmol) in EtOAc (300 mL). The resulting mixture was stirred at 60 °C for 3 h. Stirring was ceased and the reaction mixture was seeded with 10 mg of 3-methyl-l-(2,2,2-trifluoroethyl)pyrazol-4- amine tosylate and cooled to 20°C over 5 h, then left to stand at 20 °C for 22 h. The resulting mixture was filtered, rinsing twice with EtOAc (60 mL each). The resulting filter cake was collected, dried under air for 5 min, and dried under vacuum for 18 h, to afford 3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-amine tosylate (33 g, 85% yield) as a white, crystalline solid. 1H (500 MHz, DMSO-d6) d 2.19 (3H, s), 2.30 (3H, s), 5.10 (2H, q), 7.14 (2H, d), 7.45 - 7.58 (2H, m), 7.98 (1H, s), 9.86 (3H, s). c) _. MethyJ _. 6 _T ch!qro _T 5 _. -cycloprqpyJ-3 _r j;[3-methy!-! -(2, 2,2 _: tritIuoroethyl)p _. y _. razoL-4 _T ylJa _. ininqJ _. p _. yrazine-^-carbgxylate DIPEA (19.9 mL, 114 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- (trifluoromethylsulfonyloxy)pyrazine-2-carboxylate (14.75 g, 38.04 mmol) and 3-methyl-l- (2,2,2-trifluoroethyl)pyrazol-4-amine tosylate (15.0 g, 41.8 mmol) in IPA (120 mL). The resulting mixture was stirred at 60 °C for 16 h. The reaction was then stirred at 10 °C for 1 h. The resulting suspension was filtered, rinsing twice with IPA (20 mL each), twice with water (40 mL each), and once again with IPA (20 mL). The resulting filter cake was dried under vacuum at 50 °C for 16 h, to afford methyl 6-chloro-5-cyclopropyl-3-[[3-methyl-l-(2,2,2- trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxylate (11.0 g, 74% yield) as a bright yellow solid. 1H (400 MHz, DMSO-d6) d 1.23-1.16 (2H, m), 1.25 (2H, dt), 2.33 (3H, s), 2.58 (1H, tt), 4.01 (3H, s), 4.64 (2H, q), 7.91 (1H, s), 9.82 (1H, s). m/r. (ES+), [M+H] ⁺ = 390.1

Example 215

5-Cvclopropyl-3-rri-(2.2-difluoroethvn-3-methyl-pyrazol-4 -yl1aminol-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(aJ _. Iri^^-DjfluoroethylJ-j-methyJ _.y Anitro-pyrazoJe

A mixture of 3-methyl-4-nitro-lH-pyrazole (5.00 g, 39.3 mmol) and cesium carbonate (15.38 g, 47.21 mmol) was suspended in DMF (39.3 mL). l,l-difluoro-2-iodoethane (9.82 g, 51.1 mmol). The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then allowed to cool to room temperature and diluted with water. The aqueous layer was extracted three times with EtOAc. The combined organic layers were washed three times with 5% aqueous LiCl and once with brine, then dried over sodium sulfate, filtered, and concentrated. The resulting residue was purified by preparative SFC, using a 5 micron, 21 mm x 250 mm, ChiralPak IG column, 5% MeOH-sCCh as eluent, and 0.2% ammonium hydroxide as modifier, to afford l-(2,2-difluoroethyl)-3-methyl-4-nitro-lH-pyrazole (4.17 g, 55% yield) as a pale yellow oil. ¾ NMR (400 MHz, Chloroform-d): d 2.55 (3H, s), 4.43 (2H, td), 6.13 (1H, tt), 8.22 (1H, s). ¹⁹ F NMR (377 MHz, Chloroform-d): d -122.89. m/r. (ES+), [M+H]+ = 192.0 {b).lrX2 _: 2-Difluproethyl) _: 3-methyl-p_yrazol-4-amine

A mixture of l-(2,2-difluoroethyl)-3-methyl-4-nitro-lH-pyrazole (4.165 g, 21.79 mmol), 10 wt% palladium on carbon (0.835 g, 0.784 mmol) in MeOH (43.6 mL) was stirred under a hydrogen atmosphere at room temperature for 16 h. The reaction was then filtered through Celite and rinsed with DCM. The resulting filtrate was concentrated to afford l-(2,2- difluoroethyl)-3-methyl-lH-pyrazol-4-amine (3.40 g, 97% yield) as a dark orange oily solid. ¾NMR (500 MHz, Chloroform-d): d 2.16 (3H, s), 2.74 (2H, br s), 4.25 (2H, td), 5.97 (1H, tt), 6.99 (1H, s). ¹⁹ F NMR (471 MHz, CDCh): d -122.16. m/r. (ES+), [M+H]+ = 162.1.

£cj. Methyl.6-c_hJprp-5-cyclopropyJ_ _: _3_-[[l-(_2,_2-di_fluorpe_thyJJ-3-m_et_hyJ-pyraz_oJ_-4 _: ylJa.illinoJ.p.yrazine-^-carbgxylate

DIPEA (5.66 mL, 32.5 mmol) was added to a solution of l-(2,2-difluoroethyl)-3-methyl-lH- pyrazol-4-amine (2.62 g, 16.3 mmol) and methyl 6-chloro-5-cyclopropyl-3-fluoro-pyrazine-2- carboxylate (2.50 g, 10.8 mmol) in DMF (48.5 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 5% MeOH-DCM as eluent, and 0 to 0.1% methanolic ammonia as modifier, to afford methyl 6-chloro-5-cyclopropyl-3-[[l-(2,2-difluoroethyl)-3- methyl-pyrazol-4-yl]amino]pyrazine-2-carboxylate (3.67 g, 91% yield) as a yellow-orange solid. ¾ NMR (500 MHz, Chloroform-d): d 1.17 - 1.32 (4H, m), 2.32 (3H, s), 2.45 - 2.61 (1H, m), 4.01 (3H, s), 4.41 (2H, td), 6.06 (1H, tt), 7.87 (1H, s), 9.78 (1H, s). ¹⁹ F NMR (471 MHz, CDCh): d -122.19. m/z\ (ES+), [M+H]+ = 372.3

{¾ _. MethyL5_-cyclpprppyl-3 _: X[l_-(2,2_-difluproethyl) _: 3_-methyl_-pyrazol-4-yhaming] _. -6-(3 _: methyhmidazg£4 ₁ 5 _: c]pyridin-7 _: ylJpyrazine-2 _: carboxylate

1,4-Dioxane (73.4 mL) and water (7.34 mL) were added to a mixture of methyl 6-chloro-5- cyclopropyl-3-[[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl] amino]pyrazine-2-carboxylate (3.00 g, 8.07 mmol), 2-(3-methylimidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaboroca ne (2.48 g, 10.1 mmol), Pd(dppf)Ch dichloromethane adduct (0.659 g, 0.810 mmol), and cesium fluoride (3.68 g, 24.2 mmol). The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 1 hour. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, and 0 to 0.4% methanolic ammonia as modifier. The resulting dark yellow solid was slurried in 5:1 methanol/di ethyl ether and stirred at 40 °C for 1 hour. The resulting suspension was then allowed to cool to room temperature, and the solid was collected by filtration and rinsed with diethyl ether. The filtrate was concentrated, and the slurrying/filtration process was repeated twice more. The combined solids were dried under vacuum to afford methyl 5- cyclopropyl-3-[[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl] amino]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (2.64 g, 70% yield) as a bright yellow solid. ¾ NMR (500 MHz, DMSO-d6): d 0.89 - 0.97 (2H, m), 1.07 - 1.13 (2H, m), 1.79 - 1.88 (1H, m), 2.22

(1H, s), 9.05 (1H, s), 9.71 (1H, s). ¹⁹ F NMR (471 MHz, DMSO-d6): d -122.68. m/z: (ES+), [M+H]+ = 469.2.

(eJ _. ^rCycLopropyj-j^IXl^^^-diriuoroethyJJ-j^methyJ _.y pyrazoffl _. -yJJamjnoJ-ri-lj- .hl.9XhyJ_im_i_daz_o£4 ₁ 5:_c]pyri_d_in_-7 _: yJJpyraz_ine_-2 _: _carbpxami_de

7 N Methanolic ammonia (40 mL, 280 mmol) was added to methyl 5-cyclopropyl-3-[[l-(2,2- difluoroethyl)-3-methyl-pyrazol-4-yl]amino]-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxylate in a pressure flask. The resulting mixture was stirred at 80 °C for 1 hour. The reaction was then allowed to cool to room temperature. The resulting precipitate was collected by filtration and dried under vacuum to afford 5-cyclopropyl-3-[[l-(2,2- difluoroethyl)-3-methyl-pyrazol-4-yl]amino]-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (2.378 g, 94% yield) as a yellow solid. ¾ NMR (500 MHz, DMSO-d6): d 0.81 - 0.95 (2H, m), 1.04 - 1.15 (2H, m), 1.84 - 1.95 (1H, m), 2.21 (3H, s), 3.99 (3H, s), 4.56 (2H, td), 6.32 (1H, tt), 7.79 (1H, br s), 8.00 (1H, s), 8.05 (1H, br s), 8.42 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.87 (1H, s). ¹⁹ F NMR (471 MHz, DMSO-d): d -122.59. m/z:

(ES+), [M+H]+ = 454.2.

Example 216

3-rri-(T-Cvano-l-methyl-ethvD-3-methyl-pyrazol-4-vnamino1 -5-cvclopropyl-6-(3- methylimidazor4.5-clpyridin-7-yl )pyrazine-2-carboxamide

(a) Methyl 6 _r cMoro _r l-[[l _. :(l _.T cyano _r. !-methyJ-e4hy!)-3 _r meth _j J _.r pyrazpl:4-y _. l]amino]-5- cyclppropyl _r pyrazine _: 2-carboxylate DIPEA (3.00 mL, 17.3 mmol) was added to a solution of methyl 6-chloro-5 -cyclopropyl-3 - fluoro-pyrazine-2-carboxylate (2.00 g, 8.67 mmol), 2-(4-amino-3-methyl-pyrazol-l-yl)-2- methyl-propanenitrile (1.57 g, 9.54 mmol) in dioxane (30 mL). The resulting mixture was stirred at 100 °C for 48 hours. The reaction was then, allowed to cool to room temperature, diluted with EtOAc, and filtered. The filter cake was washed with water and dried under vacuum to afford methyl 6-chloro-3-[[l-(l-cyano-l-methyl-ethyl)-3-methyl-pyrazol-4- yl]amino]-5-cyclopropyl-pyrazine-2-carboxylate (2.78 g, 86% yield) as a yellow solid. 1H NMR (500MHz, DMSO-d6) 1.15 (2H, quin), 1.25 (2H, dq), 1.97 (6H, s), 2.22 (3H, s), 2.46 - 2.48 (1H, m), 3.92 (3H, s), 8.12 (1H, s), 9.61 (1H, s). m/z\ (ES+), [M+H]+ = 375.1 {b).Methyl.3_-[Ll-Q-_cyano _: l-methyl-ethyJJ-3 _: methyl _: pyrazpl-4 _r yl]aminpJ _: 5-_cycloprppyl-6-(3- methyhmMazp[4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

A mixture of methyl 6-chloro-3-[[l-(l-cyano-l-methyl-ethyl)-3-methyl-pyrazol-4-y l]amino]- 5-cyclopropyl-pyrazine-2-carboxylate (2.78 g, 7.42 mmol), 2-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (2.56 g, 10.4 mmol), and PdCh(dppf) dichloromethane adduct (0.606 g, 0.74 mmol) in 1,4-dioxane (30 mL) and water (3 mL) was evacuated and backfilled with nitrogen 3 times. The resulting mixture was stirred at 80 °C for 2 h. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 15% MeOH-DCM, to afford methyl 3-[[l-(l-cyano-l-methyl- ethyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopropyl-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (3.60 g, 98% yield) as a gray solid. 1HNMR (500MHz, DMSO- d6) 0.97 (2H, dd), 1.11 - 1.20 (2H, m), 1.80 - 1.93 (1H, m), 1.98 (6H, s), 2.28 (3H, s), 3.90 (3H, s), 4.01 (3H, s), 8.25 (1H, s), 8.41 (1H, s), 8.44 (1H, s), 9.08 (1H, s), 9.74 (1H, s). m/z\ (ES+), [M+H]+ = 470.2

_. (c) _. 3:b[l _. -(l-Cyano-l:methyl _: ethylJ-3-methyl_-pyrazgl-4 _: ylJaming] _.: 5-cyclppropyl-6 _: (3- methyhmbdazpb4 ₁ 5 _: c]pyridin-7 _: yl)pyrazine-2 _: carbgxamide

7 N Methanolic ammonia (20 mL, 140 mmol) was added to methyl 3-[[l-(l-cyano-l-methyl- ethyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopropyl-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (3.44 g, 7.30 mmol). The resulting mixture was stirred at room temperature for 20 hours, then 40 °C for 20 hours, then 60 °C for 5 hours. The reaction was then allowed to cool to room temperature and filtered to afford 3-[[l-(l-cyano-l-methyl- ethyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopropyl-6-(3-methy limidazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (2.88 g, 86% yield) as a yellow solid. 1H NMR (500 MHz, DMSO-d6) 0.90 - 1.01 (2H, m), 1.11 - 1.21 (2H, m), 1.89 - 1.94 (1H, m), 1.98 (6H, s), 2.27 (3H, s), 4.01 (3H, s), 7.83 (1H, br s), 8.09 (1H, br s), 8.26 (1H, s), 8.45 (1H, s), 8.54 (1H, s), 9.06 (1H, s), 10.93 (1H, s). m/z\ (ES+), [M+H]+ = 457.0 Example 217

3-rri-n-CvanocvclopropyD-3-methyl-pyrazol-4-yl1amino1-5-c vcloprc>pyl-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide

{4)M9thyJ..l:X3 _: methyJ_ _: 4-nitro-pyrazol-l _: ylJcyclopropanecarbpxylate Potassium carbonate (163 g, 1.18 mol) was added to a solution of 3-methyl-4-nitro-lH- pyrazole (50.0 g, 393 mmol) and methyl 2,4-dibromobutanoate (102 g, 393 mmol) in MeCN (500 mL). The resulting mixture was stirred at 60 °C for 16 hours. The reaction mixture was then filtered through celite. The resulting filtrate was concentrated to afford a 2.5:1 mixture of methyl l-(3-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarboxylate and methyl l-(5-methyl-4- nitro-pyrazol-l-yl)cyclopropanecarboxylate (100 g, 56% yield) as a brown oil

Methyl l-(3-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarboxylate: 1H NMR (400 MHz, DMSO-d6) d 1.73 (4H, s), 2.42 (3H, s), 3.64 (3H, s), 9.03 (1H, s). m/r. (ES+), [M+H]+ = 226.1

Methyl l-(5-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarboxylate: 1H NMR (400 MHz, DMSO-d6) d 1.77 - 1.89 (4H, m), 2.59 (3H, s), 3.67 (3H, s), 8.26 (1H, s). m/z\ (ES+),

[M+H]+ = 226.1

.(b)..1. -(3.-Met_hyJ-4-n it ro-p_y_razol -1 -y ! )cy cjpprppanecarbox amide

7 N Methanolic ammonia (500 mL, 3.50 mol) was added to a 2.5: 1 mixture of methyl l-(3- methyl-4-nitro-pyrazol-l-yl)cyclopropanecarboxylate and methyl l-(5-methyl-4-nitro- pyrazol-l-yl)cyclopropanecarboxylate (50.0 g, 111 mmol). The resulting mixture was stirred at room temperature for 16 hours. The resulting precipitate was filtered, washed with MeOH (50 mL), and dried under vacuum to afford l-(3-methyl-4-nitro-pyrazol-l- yl)cyclopropanecarboxamide (25 g, 53% yield) as a white solid. 1H NMR (400 MHz, DMSO- d6) d 1.43 — 1.50 (2H, m), 1.50 - 1.61 (2H, m), 2.42 (3H, s), 6.84 (1H, s), 7.40 (1H, s), 8.96 (1H, s). m/z\ (ES+), [M+H]+ = 211.1

{c) _. l:{3 _: Methyl_-4 _: nitro:pyrazol:l _. -yl)cyclppropanecarbonitrile

(Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt (2.26 g, 9.52 mmol) was added to a solution of l-(3-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarboxamide (1.00 g, 2.38 mmol) in THF (20 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated. The resulting residue was redissolved in DCM and washed sequentially with water and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford l-(3-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarbonitrile (700 mg, 77% yield) as a yellow oil. 1H NMR (400 MHz, DMSO-d6) d 1.92 (4H, s), 2.45 (3H, s), 9.15 (1H, s). m/r. (ES+), [M+H]+ = 193.1 {dJ _. L-(4rAmino-3-methyl-pyrazpl-l:yl)cyclpprppanecarbpnitr ile

Iron powder (1.627 g, 29.14 mmol) was added to a suspension of ammonium chloride (1.56 g, 29.1 mmol) and l-(3-methyl-4-nitro-pyrazol-l-yl)cyclopropanecarbonitrile (1.40 g, 7.28 mmol) in EtOH (10.00 mL) and water (10.0 mL . The resulting mixture was stirred at 60 °C for 16 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM. Pure fractions were evaporated to dryness to afford l-(4-amino-3-methyl-pyrazol-l-yl)cyclopropanecarbonitrile (1.00 g, 85% yield) as a purple solid. 1H NMR (400 MHz, DMSO-d6) d 1.61 - 1.67 (2H, m), 1.68 - 1.75 (2H, m),

2.01 (3H, s), 3.89 (2H, s), 7.07 (1H, s). m/r. (ES+), [M+H]+ = 163.3

_. (e) _. Methyl 6-chloro-3-[[l _: (l _T cyanocyclopropyl)-3 _: methyl _: pyrazoJ-4-yJ]aminp] _r 5- cyclpprppjl _r pyrazine _: 2-carboxylate

DIPEA (2.16 mL, 12.4 mmol) was added to a solution of methyl 6-chloro-5 -cyclopropyl-3 - fluoro-pyrazine-2-carboxylate (0.950 g, 4.12 mmol) and l-(4-amino-3-methyl-pyrazol-l- yl)cyclopropanecarbonitrile (0.724 g, 4.46 mmol) in DMF (25 mL). The resulting mixture was stirred at 100 °C for 5 hours. The reaction was then concentrated. The resulting residue was triturated in EtOAc and water, then filtered. The resulting solid was collected by filtration and dried under vacuum. The organic layer from the filtrate was dried over magnesium sulfate, filtered, and concentrated. The solids were combined to afford methyl 6-chloro-3-[[l- (l-cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopro pyl-pyrazine-2-carboxylate (1.472 g, 96% yield) as a yellow solid. 1H NMR (500 MHz, DMSO-d6) 1.13 (2H, quin), 1.22 - 1.27 (2H, m), 1.73 - 1.78 (2H, m), 1.86 - 1.91 (2H, m), 2.17 (3H, s), 2.44 - 2.47 (1H, m), 3.90 (3H, s), 7.98 (1H, s), 9.57 (1H, s). m/z: (ES+), [M+H]+ = 373.1(f) _. Methyl 3 _: H1 _: (1 _: cyanpcyclpprop _. yl)-3 _: methy _. l _: pyrazol _: 4-y _. l]amino]-5-cy _. clopropyl _:. 6-(3-methylimidazo[4 _: 5- c]pyridin-7 _: yl)pyrazine-2 _: carbpxylate

A mixture of methyl 6-chloro-3-[[l-(l-cyanocyclopropyl)-3-methyl-pyrazol-4-yl]am ino]-5- cyclopropyl-pyrazine-2-carboxylate (0.570 g, 1.53 mmol), 2-(3-methyl-3H-imidazo[4,5- c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (0.477 g, 1.95 mmol), PdCh(dppf) (0.129 g, 0.180 mmol), and cesium fluoride (0.697 g, 4.59 mmol) in 1,4-dioxane (8 mL) and water (0.800 mL) was degassed and purged with nitrogen three times. The resulting mixture was heated at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent and 0.2% NH40H as modifier, to afford methyl 3-[[l-(l-cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2 -carboxylate (0.684 g, 95% yield) as a yellow solid, m/z: (ES+), [M+H]+ = 470.0

_. (g) _. 3 _. -[Ll _.-. (l _. -Cyanocyclpprppyl) _: 3-methyl _. -p _. yrazpl-4 _: yl] _. aminpl-5 _: cyclpprppyl-6 _: (3- methyhmidazp[4 ₁ 5 _: c]py _. ridin-7 _: yl)pyrazine-2 _: carboxamide 7 N Methanolic ammonia (30 mL, 210 mmol) was added to methyl 3-[[l-(l- cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopropyl -6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxylate (1.85 g, 3.95 mmol). The resulting mixture was stirred at room temperature for 19 hours, then 40 °C for 6 hours, then at room temperature for 2 days. The reaction was then concentrated. The resulting residue was washed with 50% EtOAc in hexanes and dried under vacuum. The resulting material was purified by silica gel chromatography, using 0 to 6% MeOH-DCM as eluent, and 0.2% ammonium hydroxide as modifier, to afford 3-[[l-(l-cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5-cy clopropyl- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide (1.14 g, 63% yield) as a yellow solid. 1H NMR (500 MHz, DMSO-d6) 0.92 - 1.01 (2H, m), 1.11 - 1.20 (2H, m), 1.78 - 1.83 (2H, m), 1.87 - 1.96 (3H, m), 2.24 (3H, s), 4.01 (3H, s), 7.84 (1H, br s), 8.10 (1H, br s), 8.11 (1H, s), 8.45 (1H, s), 8.54 (1H, s), 9.06 (1H, s), 10.93 (1H, s). m/z: (ES+), [M+H]+ = 455.0

Example 218

5-Cvclopropyl-3-r(E5-dimethylpyrazol-4-vDamino1-6-(3-meth ylimidazor4.5-c1pyridin-7- vDpyrazine-2-carboxamide iaJ _. MMbyl _. ^-cMQro-S-c _j cJ _. opropyl^j-fi l^diiTiethylpyrazol-^^yJjarriinpJpyrazine-?- carbpxylate

DIPEA (0.379 mL, 2.17 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (0.10 g, 0.43 mmol), and l,5-dimethylpyrazol-4-amine dihydrochloride (0.160 g, 0.87 mmol) in DMF (3.0 mL). The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then diluted with DCM and water. The layers were separated and the aqueous layer was extracted with DCM. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford methyl 6-chloro-5- cyclopropyl-3-[(l,5-dimethylpyrazol-4-yl)amino]pyrazine-2-ca rboxylate as a yellow solid. 1H NMR (500MHz, DMSO-d6) d 0.93 - 1.01 (2H, m), 1.12 - 1.18 (2H, m), 2.16 (3H, s), 2.38 - 2.43 (1H, m), 3.72 (3H, s), 3.88 (3H, s), 7.52 (1H, s), 9.33 (1H, s). m/r. (ES-), [M-H]- = 320.1 {¾.6-Chlprp-5-cycloprppyl-3-[_(l_ ₁ 5 _: dimethylpyrazpl-4 _: ylJaminpJpyrazine-2-carbpxamide 7 N Methanolic ammonia (4.0 mL, 28 mmol) was added to methyl 6-chloro-5-cyclopropyl-3- [(l,5-dimethylpyrazol-4-yl)amino]pyrazine-2-carboxylate (0.138 g, 0.430 mmol). The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then concentrated to afford 6-chloro-5-cyclopropyl-3-[(l,5-dimethylpyrazol-4-yl)amino]py razine-2-carboxamide (0.132 g, quantitative) as a yellow solid. 1HNMR (500MHz, DMSO-d6) d 0.96 - 1.05 (2H, m), 1.09 - 1.19 (2H, m), 2.17 (3H, s), 2.37 - 2.43 (1H, m), 3.71 (3H, s), 7.58 (1H, s), 7.82 (1H, s), 8.07 (1H, s), 10.50 (1H, s). m/r. (ES+), [M+H]+ = 306.8

{cj.S^Cyclpprppyl-^^l _^ S-dimethylpyrazpEfl.-y.lJaminpJ-e-Q-methylimidazpt^S-c Jpyridin-Y- y _. Upyra?ine-2 _: carbpxaiPide

A mixture of 6-chloro-5-cyclopropyl-3-[(l,5-dimethylpyrazol-4-yl)amino]py razine-2- carboxamide (0.132 g, 0.430 mmol), 2-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l, 3,6,2- dioxazaborocane (0.158 g, 0.65 mmol), and PdCh(dppf) (0.063 g, 0.090 mmol) in 2 M aqueous potassium phosphate (0.645 mL, 1.29 mmol) and 1,4-dioxane (3.0 mL) was degassed and purged with nitrogen. The resulting mixture was stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was triturated in water, then dried under vacuum. The resulting solid was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent. The resulting material was further purified by reverse phase C18 chromatography, using 0 to 25% MeCN-water as eluent, and 0.1% formic acid as modifier, to afford 5- cyclopropyl-3-[(l, 5-dim ethylpyrazol-4-yl)amino]-6-(3-methylimidazo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (0.098 g, 57% yield) as a yellow solid. 1H NMR (500MHz,

DMSO-d6) d 0.82 - 0.92 (2H, m), 0.95 - 1.06 (2H, m), 1.83 - 1.90 (1H, m), 2.23 (3H, s), 3.74

9.02 (1H, s), 10.59 (1H, s). m/z: (ES+), [M+H]+ = 403.9 Example 219

5-Cvclopropyl-6-(3-methylimidazor4.5-c1pyridin-7-vD-3-r(3 -methyl-lEl-pyrazol-4- vDaminolpyrazine-2-carboxamide

(a) Methyl :I(1 rtert-butoxy carbonyl _: 3 _-methyl-pyrazol-4-yl)amino]-6 _: chlpro-5-cyclpprppyl: pyiazine-2-carbpxylate

DIPEA (3.40 mL, 19.5 mmol) was added to a solution of methyl 6-chloro-5 -cyclopropyl-3 - fluoro-pyrazine-2-carboxylate (1.50 g, 6.50 mmol) and tert- butyl 4-amino-3-methyl-pyrazole- 1-carboxylate (1.92 g, 9.76 mmol) in DMF (18.3 mL). The resulting mixture was stirred at 60 °C for 16 hours. The reaction mixture was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 5% MeOH-DCM as eluent, and 0 to 0.1% methanolic ammonia as modifier, to afford methyl 3 -[(1 -/cvV-butoxy carbonyl -3-methyl- pyrazol-4-yl)amino]-6-chloro-5-cyclopropyl-pyrazine-2-carbox ylate (2.207 g, 83% yield) as a dark orange foam. ¹ HNMR (500 MHz, Chloroform-d): d 1.26 - 1.33 (4H, m), 1.66 (9H, s),

2.40 (3H, s), 2.54 - 2.63 (1H, m), 4.00 (3H, s), 8.43 (1H, s), 9.92 (1H, s). m/z\ (ES+), [M+H]+ = 408.1

{b).Methyl.3_-[(_l-tert-butoxycarbonyl _: 3-methyl-pyrazpl-4 _: yl)aminp]. _: 5-cyclpprgpyl-6 _: _(3 _: methyhmidazp£4 ₁ 5 _: c]pyridin _: 7 _: yljpyrazine-2 _: carbpxylate A mixture of methyl 3-[(l-/er/-butoxycarbonyl-3-methyl-pyrazol-4-yl)amino]-6-chl oro-5- cyclopropyl-pyrazine-2-carboxylate (2.21 g, 5.41 mmol) was charged with 2-(3-methyl-3H- imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazaborocane (1.47 g, 5.95 mmol), Pd(dppf)C12 dichloromethane adduct (0.442 g, 0.540 mmol), and cesium fluoride (2.466 g, 16.23 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (19.7 mL) and water (2.0 mL) were added. The resulting mixture was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0 to 0.2% methanolic ammonia as modifier, to afford methyl 3-[(l-tert-butoxycarbonyl-3- methyl-pyrazol-4-yl)amino]-5-cyclopropyl-6-(3-methylimidazo[ 4,5-c]pyridin-7-yl)pyrazine-

2-carboxylate (1.513 g, 55% yield) as a dark yellow-orange foam. ¹ HNMR (500 MHz, Chloroform-d): d 1.02 - 1.09 (2H, m), 1.35 - 1.40 (2H, m), 1.67 (9H, s), 1.96 - 2.10 (1H, m), 2.45 (3H, s), 3.98 (3H, s), 4.01 (3H, s), 8.01 (1H, s), 8.59 (1H, s), 8.68 (1H, s), 8.92 (1H, s), 10.09 (1H, s). m/z\ (ES+), [M+H]+ = 505.3

_. (c) _. 5 ₇ Cyclopropyl-6 _T (3-methyJirnidazo[4,5-c]pyridiri-7 _T y]) _T 3-[0 _.-. rnethy] _.-. LH ₇ pyrazoJ _: 4- yD¾rninp] _. pyrazine ₇ 2-_carbgxamide

7 N Methanolic ammonia (13 mL, 91 mmol) was added to methyl 3-[(l-tert-butoxycarbonyl-

3-methyl-pyrazol-4-yl)amino]-5-cyclopropyl-6-(3-methylimi dazo[4,5-c]pyridin-7- yl)pyrazine-2-carboxylate (1.513 g, 3.000 mmol). The resulting mixture was stirred at 100 °C for 2 hours in a pressure flask. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 40% MeOH-DCM as eluent, and 0 to 0.4% methanolic ammonia as modifier. The resulting material was suspended in MeOH/diethyl ether and stirred at 40 °C for 4 hours. The resulting slurry was allowed to cool to room temperature, then filtered, rinsed with diethyl ether, and dried under vacuum to afford 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-met hyl-lH-pyrazol-4- yl)amino]pyrazine-2-carboxamide (0.647 g, 51% yield) as a yellow solid. The compound exists as a 2:1 mixture of pyrazole tautomers. ¾ NMR (500 MHz, DMSO-d6): d 0.80 - 0.97 (2H, m), 0.97 - 1.12 (2H, m), 1.80 - 1.94 (1H, m), 2.21 (3H, s), 3.98 (3H, s), 7.69 - 7.96 (2H, m), 8.02 (1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.02 (1H, s), 10.45 - 10.94 (1H, m), 12.17 - 12.54 (1H, m). m/r. (ES+), [M+H]+ = 390.1

Examples 220-223 5-Cvclopropvl-6-(3-methvlimidazor4,5-c1pvridin-7-vl)-3-rr3-m ethvl-l-lrel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide, 5-cyclopropyl-6-(3- methylimidazor4,5-c]pyridin-7-yl)-3-rr3-methyl-l-rrel-(2S)-2 ,3-difluoropropyl]pyrazol-4- yl]amino]pyrazine-2-carboxamide, 5-cyclopropyl-6-(3-methylimidazol4,5-c1pyridin-7-yl)-3- rr5-methyl-l-lrel-(2R)-2,3-difluoropropyl]pyrazol-4-yl]amino ]pyrazine-2-carboxamide, and 5-cyclopropyl-6-(3-methylimidazor4,5-c1pyridin-7-yl)-3-rr5-m ethyl-l-lrel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide

£a) 2,3 -Difluoroproyy 1 4 _: methylb enzenesulfpnate

4-Methylbenzenesulfonyl chloride (149 mg, 0.780 mmol) was added to a solution of 2,3- difluoropropan-l-ol (50 mg, 0.52 mmol), and triethylamine (107 pL, 0.780 mmol) in DCM (2.5 mL). The resulting mixture was stirred at room temperature for 3 hours. The reaction was then quenched with saturated aqueous ammonium chloride (3 mL). The layers were separated and the aqueous layer was extracted three times with DCM (3 mL each). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The resulting residue was carried forward assuming 100% yield. m/r. (ES+), [M+H]+ = 251.0 {b).5-Cyclppropyl-6 _: {3 _: methylimid^o£4^5 _: c]pyridin-7 _: yl)-^ > difluQrppropylJpyrazoM^ylJaminpJpyrazine-^-carboxamide^ S-cyclppropyl-d-Q- methyXim£dazo£4 ₁ 5 ₇ c]pyr£din-7 ₇ yl) ₇ 3-X£3 ₇ methyl ₇ l ₇ £rel ₇ X2S) ₇ 2 _J 3-difluoropropyllpyrazol-4- ylJaminpIpyrazine-2-parboxam£de _J .5-cyp)ppropyL6 ₇ X3-methyl£midayo£4 _I 5 ₇ c]pyr£din ₇ 7 ₇ yl)-3 ₇ £[57methyd ₇ d-£rel ₇ X2R) ₇ 2,3-dj.fluproprppyd]pyrazpL4 ₇ yd]aminpJpyrazine-2 ₇ carbpxamj.de,.and 57cycloprppyl ₇ 6 ₇ £3 ₇ methyhmidazp£4 ₁ 5 ₇ clpyr£din ₇ 7 ₇ yl) ₇ 3-[£5 ₇ methyl ₇ l ₇ £re£-X2S)-2 _J 3- difluQrppropylJpyrazo£-4 ₇ ylJam£np]pyrazine-2-carboxamide Cesium carbonate (335 mg, 1.03 mmol) was added to a mixture of 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-methyl-lH-pyrazol-4- yl)amino]pyrazine-2- carboxamide (100 mg, 0.26 mmol) and 2,3-difluoropropyl 4-methylbenzenesulfonate (129 mg, 0.510 mmol) in DMSO (0.856 mL). The resulting mixture was stirred at 100 °C for 1.5 hours. The reaction was then allowed to cool to room temperature and concentrated. The resulting residue was purified by reverse phase Cl 8 chromatography, using 0 to 40% MeCN- water as eluent, and 0.1% formic acid as modifier. The resulting material was further purified by preparative SFC, using a 5 micron, 4.6 mm x 100 mm, ChiralPak IG column, using isocratic 45% MeOH-sCC as eluent, and 0.2% ammonium hydroxide as modifier, to afford three portions of material: 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5- methyl-l-[rel-(2R)-2,3-difluoropropyl]pyrazol-4-yl]amino]pyr azine-2-carboxamide (14.3 mg, 12% yield) as a yellow solid, 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5- methyl-l-[rel-(2S)-2,3-difluoropropyl]pyrazol-4-yl]amino]pyr azine-2-carboxamide (14.6%, 12% yield) as a yellow solid, and a yellow solid. This latter material was further purified by preparative SFC, using a 3 micron, 4.6 mm x 100 mm, ChiralPak IA column, using isocratic 20% MeOH-sCCh as eluent, and 0.2% ammonium hydroxide as modifier, to afford 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-met hyl-l-[rel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide (16.1 mg, 13% yield) as a yellow solid and 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l-[rel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide (16.5 mg, 14% yield) as yellow solid.

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-[rel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide. 1H NMR (500MHz, DMSO-d6) 1H NMR (500 MHz, DMSO-d6) 0.80 - 0.97 (2H, m), 1.00 - 1.18 (2H, m), 1.77 - 1.95 (1H, m), 2.20 (3H, s), 3.99 (3H, s), 4.28 - 4.85 (4H, m), 4.93 - 5.23 (1H, m), 7.80 (1H, br s), 7.97 (1H, s), 8.06 (1H, br s), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.86 (1H, s). m/z (ES+), [M+H]+ = 468.0

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 3-methyl-l-[rel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide. 1H NMR (500 MHz, DMSO-d6) 0.80 - 0.97 (2H, m), 1.06 - 1.16 (2H, m), 1.82 - 1.93 (1H, m), 2.20 (3H, s), 3.98 (3H, s), 4.31 - 4.86 (4H, m), 4.93 - 5.25 (1H, m), 7.80 (1H, br s), 7.97 (1H, s), 8.06 (1H, br s), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.85 (1H, s). m/z: (ES+), [M+H]+ = 468.0 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-m ethyl-l-[rel-(2R)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide. 1H NMR (500 MHz, DMSO-d6) 0.79 - 0.93 (2H, m), 0.93 - 1.05 (2H, m), 1.80 - 1.92 (1H, m), 2.24 (3H, s), 3.98 (3H, s), 4.34 - 4.88 (4H, m), 4.99 - 5.24 (1H, m), 7.78 (1H, br s), 7.81 (1H, s), 8.04 (1H, br s), 8.43 (1H, s), 8.50 (1H, s), 9.03 (1H, s), 10.60 (1H, s). m/z\ (ES+), [M+H]+ = 468.0

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 5-methyl-l-[rel-(2S)-2,3- difluoropropyl]pyrazol-4-yl]amino]pyrazine-2-carboxamide. 1H NMR (500 MHz, DMSO-d6) 0.76 - 0.93 (2H, m), 0.93 - 1.06 (2H, m), 1.79 - 1.92 (1H, m), 2.24 (3H, s), 3.98 (3H, s), 4.32 - 4.87 (4H, m), 4.98 - 5.24 (1H, m), 7.78 (1H, br s), 7.81 (1H, s), 8.04 (1H, br s), 8.43 (1H, s), 8.50 (1H, s), 9.03 (1H, s), 10.60 (1H, s). m/z\ (ES+), [M+H]+ = 468.0

Example 224 and 225

5-Cvclopropyl-6-(3-methylimidazor4.5-clPyridin-7-vO-3-IT3 -methyl-l-(oxetan-3-vOpyrazol- 4-yllaminolpyrazine-2-carboxamide and 5-cvclopropyl-6-(3-methylimidazor4.5-clpyridin-7- viy3-rr5-methyl-l-(oxetan-3-vDpyrazol-4-yllaminolpyrazine-2- carboxamide

3-Iodooxetane (132 μL, 1.50 mmol) was added to a suspension of 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-methyl-lH-pyrazol-4- yl)amino]pyrazine-2- carboxamide (168 mg, 0.430 mmol) and cesium carbonate (421 mg, 1.30 mmol) in DMSO (2 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction mixture was directly purified by reverse phase C18 chromatography, using 0 to 100% MeCN/water as eluent, and 0.2% ammonium hydroxide as modifier, to afford a yellow film (128 mg). This material was further purified by preparative SFC, using a 5 micron, 21 mm x 250 mm, OJ-H column, isocratic 25% MeOH-sCCh as eluent, and 0.2% ammonium hydroxide as modifier, to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l-(oxetan-3-yl)pyrazol-

4-yl]amino]pyrazine-2-carboxamide (55 mg, 64% yield) as a yellow solid and 5-cyclopropyl- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-l-(oxeta n-3-yl)pyrazol-4- yl]amino]pyrazine-2-carboxamide (27 mg, 32% yield) as a yellow solid. 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-m ethyl-l-(oxetan-3-yl)pyrazol- 4-yl]amino]pyrazine-2-carboxamide: ¾NMR (500 MHz, DMSO-d6): d 0.86 - 0.96 (2H, m),

1.06 - 1.16 (2H, m), 1.86 - 1.94 (1H, m), 2.25 (3H, s), 3.99 (3H, s), 4.86 (2H, br t), 4.89 - 4.97 (2H, m), 5.40 - 5.56 (1H, m), 7.79 (1H, br s), 8.05 (1H, br s), 8.08 (1H, s), 8.42 (1H, s), 8.52 (1H, d), 9.03 (1H, d), 10.89 (1H, s). m/z (ES+), [M+H]+ = 446.2

5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[ 5-methyl-l-(oxetan-3-yl)pyrazol- 4-yl]amino]pyrazine-2-carboxamide: ¾ NMK (500 MHz, DMSO-d6): d 0.82 - 0.94 (2H, m), 1.03 (2H, dt), 1.81 - 1.94 (1H, m), 2.21 (3H, s), 3.98 (3H, s), 4.83 - 4.92 (2H, m), 4.92 - 4.99

(2H, m), 5.58 (1H, quin), 7.75 (1H, br s), 7.95 (1H, s), 8.02 (1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.03 (1H, s), 10.65 (1H, s). m/z: (ES+), [M+H]+ = 446.2

Example 226

5-Cvclopropyl-3-rri-(2.2-difluorc>ethvD-5-methyl-pyraz ol-4-yl1amino1-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide l,l-Difluoro-2-iodo-ethane (38 μL, 0.44 mmol) was added to a suspension of 5-cyclopropyl- 6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-methyl-lH-pyraz ol-4-yl)amino]pyrazine-2- carboxamide (85 mg, 0.22 mmol and cesium carbonate (213 mg, 0.650 mmol) in DMSO (1 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction mixture was purified directly by reverse phase Cl 8 chromatography, using 0 to 100% MeCN-water as eluent, and 0.2% ammonium hydroxide as modifier, to afford a yellow solid (88 mg). This material was further purified by preparative SFC, using a 5 micron, 21 mm x 250 mm, IB column, isocratic 35% MeOH-sCCh as eluent, and 0.2% NH ₄ OH as modifier, to afford 5- cyclopropyl-3-[[l-(2,2-difluoroethyl)-3-methyl-pyrazol-4-yl] amino]-6-(3-methylimidazo[4,5- c]pyridin-7-yl)pyrazine-2-carboxamide (48 mg, 49% yield) and 5-cyclopropyl-3-[[l-(2,2- difluoroethyl)-5-methyl-pyrazol-4-yl]amino]-6-(3-methylimida zo[4,5-c]pyri din-7- yl)pyrazine-2-carboxamide (23 mg, 23% yield) as yellow solids. 5-Cyclopropyl-3-[[l-(2,2-difluoroethyl)-5-methyl-pyrazol-4-y l]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide: ¾NMR (500 MHz, DMSO-d6): d 0.76 - 0.94 (2H, m), 0.94 - 1.12 (2H, m), 1.78 - 1.96 (1H, m), 2.26 (3H, s), 3.98 (3H, s), 4.57 (2H, td), 6.34 (1H, tt), 7.76 (1H, br s), 7.83 (1H, s), 8.02 (1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.03 (1H, s), 10.60 (1H, s). ¹⁹ F NMR (471 MHz, DMS0-d6): d -122.12. m/z\ (ES+), [M+H]+ = 454.2

Examples 227 and 228

5-Cvclopropyl-3-rri-(3.3-difluoroprc>pyD-3-methyl-pyra zol-4-yl1amino1-6-(3- methylimidazor4.5-c1pyridin-7-vDpyrazine-2-carboxamide and 5-cvclopropyl-3-ril-(3.3- difluoropropyD-5-methyl-pyrazol-4-yl1amino1-6-(3-methylimida zor4.5-c1pyridin-7- vDpyrazine-2-carboxamide

3,3-Difluoropropyl methanesulfonate (112 mg, 0.640 mmol) was added to a suspension of 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-met hyl-lH-pyrazol-4- yl)amino]pyrazine-2-carboxamide (100 mg, 0.26 mmol) and cesium carbonate (251 mg, 0.770 mmol) in DMSO (2.0 mL). The resulting mixture was stirred at 100 °C for 1 hour. The reaction was allowed to cool to room temperature and purified directly by reverse phase Cl 8 chromatography, using 0 to 80% MeCN-water as eluent, and 0.2% ammonium hydroxide as modifier, to afford 116 mg of a yellow solid. This material was purified by preparative SFC using a 5 micron, 21 mm x 250 mm ChiralPak IJ column, isocratic 20% MeOH-sCCh as eluent, and 0.2% ammonium as modifier, to afford 5-cyclopropyl-3-[[l-(3,3-difluoropropyl)- 3-methyl-pyrazol-4-yl]amino]-6-(3-methylimidazo[4,5-c]pyridi n-7-yl)pyrazine-2- carboxamide (44 mg, 37% yield) as a yellow solid and 5-cyclopropyl-3-[[l-(3,3- difluoropropyl)-5-methyl-pyrazol-4-yl]amino]-6-(3-methylimid azo[4,5-c]pyridin-7- yl)pyrazine-2-carboxamide (38 mg, 32% yield) as yellow solids. 5-Cyclopropyl-3-[[l-(3,3-difluoropropyl)-3-methyl-pyrazol-4- yl]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide. ¾ NMR (500 MHz, DMSO-d6): d 0.90 (2H, br dd), 1.10 (2H, br s), 1.85 - 1.92 (1H, m), 2.19 (3H, s), 2.27 - 2.48 (2H, m), 3.98 (3H, s), 4.21 (2H, t), 6.10 (1H, tt), 7.77 (1H, br s), 7.93 (1H, s), 8.03 (1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.03 (1H, s), 10.80 (1H, s). ¹⁹ F NMR (471 MHz, DMS0-d6): d -116.50. m/r (ES+), [M+H]+ = 468.2

5-Cyclopropyl-3-[[l-(3,3-difluoropropyl)-5-methyl-pyrazol -4-yl]amino]-6-(3- methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide. ¾ NMR (500 MHz, DMS0-d6): 0.86 (2H, br dd), 1.00 (2H, br s), 1.83 - 1.90 (1H, m), 2.25 (3H, s), 2.28 - 2.41 (2H, m), 3.98 (3H, s), 4.20 (2H, br t), 6.12 (1H, tt), 7.75 (1H, br s), 7.79 (1H, s), 8.01 (1H, br s), 8.42 (1H, s), 8.50 (1H, s), 9.02 (1H, s), 10.60 (1H, s). ¹⁹ F NMR (471 MHz, DMS0-d6): d -116.48. m/r (ES+), [M+H]+ = 468.2.

Example 229 and 230

5-Cvclopropyl-6-(3-methylimidazor4.5-clpyridin-7-yl )-3-IY3 -methyl - 1 -tetrahydropyran-4-yl- pyrazol-4-vDaminolpyrazine-2-carboxamide and 5-cycl opropyl-6-(3 -methyl i mi dazol4,5- clpyridin-7-vD-3-r(5-methyl-l-tetrahvdropyran-4-yl-pyrazol-4 -vDaminolpyrazine-2- carboxamide

{4).3:M.Qthyl-4:nitrg _r J -tetrahydrgpyran-4 _: yl _: pyrazole and 5-methyl-4-nitro- 1 _{: .} tetxahydropyran _: 4-yl _r pyrazgle

DMF (5 mL) was added to a mixture of 3-methyl-4-nitro-lH-pyrazole (0.508 g, 4.00 mmol), tetrahydro-2H-pyran-4-yl methanesulfonate (0.865 g, 4.80 mmol), and cesium carbonate (1.56 g, 4.80 mmol). The resulting suspension was stirred at 100 °C for 18 hours. The reaction was then diluted with water (15 mL). The resulting precipitate was collected by filtration, rinsed with water, and dried under air to afford a 2: 1 mixture of 3-methyl-4-nitro-l-tetrahydropyran- 4-yl-pyrazole and 5-methyl-4-nitro-l-tetrahydropyran-4-yl-pyrazole (0.423 g, 50% yield) as a white, fluffy solid. 3-methyl-4-nitro-l-tetrahydropyran-4-yl-pyrazole. 1HNMR (500 MHz, CHLOROFORM-d) 1.96 - 2.09 (2H, m), 2.10 - 2.17 (2H, m), 2.55 (3H, s), 3.48 - 3.60 (2H, m), 4.09 - 4.19 (2H, m), 4.29 (1H, tq), 8.16 (1H, s). m/z: (ES+), [M+H]+ = 212.0

5-methyl-4-nitro-l-tetrahydropyran-4-yl-pyrazole. 1HNMR (500 MHz, CHLOROFORM-d) 1.77 - 1.91 (2H, m), 2.34 (2H, qd), 2.70 (3H, s), 3.48 - 3.60 (2H, m), 4.09 - 4.19 (2H, m), 4.29 (1H, tq), 8.11 (1H, s). m/z: (ES+), [M+H]+ = 212.0

{¾ _. 3 _r Methyl _: l-tetrahydrp _. pyran-4-yl-pyrazol-4-amine _. and 5_-methyl_-l _: tetrahydrppyran _: 4_-yl _: pyrazpl _: 4-amine

A mixture of 10 wt% palladium on carbon (85 mg, 0.080 mmol) and 2: 1 mixture of 3-methyl- 4-nitro-l-tetrahydropyran-4-yl-pyrazole and 5-methyl-4-nitro-l-tetrahydropyran-4-yl- pyrazole (423 mg, 2.00 mmol) in MeOH (8 mL) was stirred under a hydrogen atmosphere at room temperature for 4 hours. The reaction was then filtered through Celite and rinsed with DCM. The resulting filtrate was concentrated to afford a 2:1 mixture of 3 -methyl- 1- tetrahydropyran-4-yl-pyrazol -4-amine and 5-methyl- 1 -tetrahydropyran-4-yl-pyrazol-4-amine (340 mg, 94% yield) as a dark purple oil. m/z: (ES+), [M+H]+ = 182.8.

{c)Methy) _.. 6-chlorg-5-cycloprppyl:3_-[(3-methyl-l-tetrahydrppyran -4-yl-pyrazpl-4- ylJa.ininpJ.pjrazine-^-parbgxylate and methyl.6-chlprg-5-cycloprppy.l _: 3-_[(5-methyl-l- .tetrahy_drgpyran _: _4_-y_l _: pyrazgl_ _: _4_-y_l)_arnj_ng]py_razi_ne-2-c_arbgxy_late

DIPEA (0.657 mL, 3.77 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (290 mg, 1.26 mmol) and a 2: 1 mixture of 3-methyl-l- tetrahydropyran-4-yl-pyrazol -4-amine and 5-methyl- 1 -tetrahydropyran-4-yl-pyrazol-4-amine (342 mg, 1.89 mmol) in DMF (5.6 mL). The resulting mixture was stirred at 100 °C for 45 minutes. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 5% MeOH-DCM as eluent, and 0 to 0.1% methanolic ammonia as modifier to afford a 2: 1 mixture of methyl 6-chloro-5-cyclopropyl-3-[(3-methyl-l- tetrahydropyran-4-yl-pyrazol-4-yl)amino]pyrazine-2-carboxyla te and methyl 6-chloro-5- cyclopropyl-3-[(5-methyl-l-tetrahydropyran-4-yl-pyrazol-4-yl )amino]pyrazine-2-carboxylate (0.420 g, 85 % yield) as an orange-brown solid. ¹ HNMR (500 MHz, Chloroform-d): d 1.14 - 1.17 (2H, m), 1.17 - 1.34 (2H, m), 1.83 - 2.18 (3H, m), 2.25 - 2.39 (4H, m), 2.47 - 2.62 (1H, m), 3.51 - 3.61 (2H, m), 3.96 - 4.03 (3H, m), 4.11 - 4.18 (2H, m), 4.19 - 4.33 (1H, m), 7.76 -

7.90 (1H, m), 9.44 - 9.84 (1H, m). m/z: (ES+), [M+H]+ = 391.5 £d).Methyl 5_-cy_dop_ropyJ-6-(3 _: _methylj.midaz_o£4 ₁ 5 _: _c]pyri_di_n-7 _: yJJ-3_-[_(3 _: _iri_ethxl_ _: _l - tetrahy_dropyran _: _4_-y_l _: pyrazoJ. ₇ 4-yJJamjn_o]py_razine-2-c_arboxy_late an_d.rnethyJ_ 5-cy_cl_opropyJ_ _: _6- i3-methylimidazgj4 _^ 5-c]pyridin-7 _.r ylj _r 3-[£5-methyl-l _r tetrahydrppyran _r 4-yl _. -pyrazol-4- y _. U¾rninp] _. pyrazine-2-carbgxylate

A mixture of 2-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-l,3,6,2-dioxazabo rocane (386 mg, 1.57 mmol) 2:1 methyl 6-chloro-5-cyclopropyl-3-[(3-methyl-l-tetrahydropyran-4-yl-p yrazol- 4-yl)amino]pyrazine-2-carboxylate and methyl 6-chloro-5-cyclopropyl-3-[(5-methyl-l- tetrahydropyran-4-yl-pyrazol-4-yl)amino]pyrazine-2-carboxyla te (410 mg, 1.05 mmol), Pd(dppf)Ch dichloromethane adduct (85 mg, 0.10 mmol), and cesium fluoride (477 mg, 3.14 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (9.5 mL) and water (0.95 mL) and the resulting slurry was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 20 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0 to 0.2% methanolic ammonia as modifier, to afford a 2: 1 mixture of methyl 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-met hyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(5-methyl-l-tetrahydrop yran-4-yl-pyrazol-4- yl)amino]pyrazine-2-carboxylate (0.157 g, 31% yield) as an orange film. m/r. (ES+), [M+H]+ = 489.2.

_. (e) _. 5 ₇ Cyclopropyl-6 _T (3-methyJjmidazo[4,5-c]pyridiri-7 _T y]) _T 3 _.-. [(3 _. -m _. ethyl-l _: tetrahydropyrari _: 4- yl-pyra? _.Q l _. -4 ₇ yl)aminp4pyrazine ₇ 2 ₇ carbgxamide and _. 5 ₇ cyclopropyl _7. 6-_(3-methylimidazg[4,5 _7. cIpyU!din-7 ₇ yJ)-3_ ₇ [_(5 ₇ _me_thyJ_ ₇ _l -tetrahy_drgpyjan-4 ₇ yJ_-_p_yrazgl-4 ₇ yJ)_ami_ng]pyrazi_ne ₇ _2-_ carboxamide

7 N Methanolic ammonia (4.6 mL, 32 mmol) was added to a 2: 1 mixture of methyl 5- cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-met hyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(3- methylimidazo[4,5-c]pyridin-7-yl)-3-[(5-methyl-l-tetrahydrop yran-4-yl-pyrazol-4- yl)amino]pyrazine-2-carboxylate (157 mg, 0.320 mmol). The resulting mixture was stirred at 100 °C for 30 minutes in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by reverse phase C18 chromatography, using 0 to 80% MeCN-water as eluent, and 0.2% ammonium hydroxide as modifier, to afford a yellow film. This material was further purified by preparative SFC, using a 5 micron, 21 mm x 250 mm ChiralPak IJ column, isocratic 20% MeOH-sCCh as eluent, and 0.2% ammonium as modifier, to afford 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(3-m ethyl-l- tetrahydropyran-4-yl-pyrazol-4-yl)amino]pyrazine-2-carboxami de (33 mg, 22% yield) as a yellow solid and 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(5-m ethyl-l- tetrahydropyran-4-yl-pyrazol-4-yl)amino]pyrazine-2-carboxami de (68 mg, 45% yield) as a yellow solid.

5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[( 3-methyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxamide: ¾ NMK (500 MHz, DMSO-d6): d 0.86 - 0.97 (2H, m), 1.06 - 1.15 (2H, m), 1.82 - 1.94 (3H, m), 2.00 (2H, br d), 2.20 (3H, s), 3.48 (2H, br t), 3.96 (2H, br d), 3.99 (3H, s), 4.25 - 4.37 (1H, m), 7.77 (1H, br s), 8.00 (1H, s), 8.03 (1H, br s), 8.43 (1H, s), 8.52 (1H, s), 9.03 (1H, s), 10.81 (1H, s). m/r. (ES+), [M+H]+ = 474.3

5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[( 5-methyl-l-tetrahydropyran-4-yl- pyrazol-4-yl)amino]pyrazine-2-carboxamide: ¾ NMK (500 MHz, DMSO-d6): d 0.87 (2H, br dd), 0.99 - 1.06 (2H, m), 1.80 (2H, br d), 1.83 - 1.91 (1H, m), 1.96 - 2.09 (2H, m), 2.28 (3H, s), 3.49 (2H, br t), 3.92 - 4.02 (5H, m), 4.33 - 4.45 (1H, m), 7.74 (1H, br s), 7.81 (1H, s), 8.01

(1H, br s), 8.42 (1H, s), 8.51 (1H, s), 9.02 (1H, s), 10.64 (1H, s). m/r. (ES+), [M+H]+ = 474.2

Example 231 and 232

5-Cvclopropyl-6-(T-methylbenzimidazol-4-vO-3-rr3-methyl-l -(T-methyl-4-piperidvOpyrazol- 4-yl1amino1pyrazine-2-carboxamide and 5-cvclopropyl-6-(l-methylbenzimidazol-4-vn-3-rr5-

{4)2?/7:Butyl.4^(3rmethyl_-4 _: nitro _: pyrazd _: X-ylJpiperidine-J. _: carbpxylate and./er/-Butyl.4-(5_- methyE4-mtrp-pyrazol-l:ylJpipendine:l-carboxylate DMF (9.8 mL) was added to a mixture of 3-methyl-4-nitro-lH-pyrazole (1.00 g, 7.87 mmol), tert-butyl 4-methylsulfonyloxypiperidine-l-carboxylate (2.86 g, 10.2 mmol), and cesium carbonate (3.08 g, 9.44 mmol). The resulting mixture was stirred at 100 °C for 3 hours. The reaction was then allowed to cool to room temperature, diluted with water, and extracted three times with EtOAc. The combined organic layers were washed three times with 5% aqueous LiCl and once with brine, then dried over sodium sulfate, filtered, and concentrated to afford a 2: 1 mixture of /er/-butyl 4-(3-methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate and tert- butyl 4-(5-methyl-4-nitro-pyrazol-l-yl)piperidine-l-carboxylate (2.79 g, quantitative) as a waxy white solid. ¾ NMR (500 MHz, Chloroform-d): d 1.32 - 1.62 (9H, m), 1.79 - 1.93 (2H, m), 2.09 - 2.19 (2H, m), 2.48 - 2.71 (3H, m), 2.76 - 2.95 (2H, m), 4.10 - 4.51 (3H, m), 8.04 - 8.17 (1H, m). m/z: (ES+), [M+H]+ = 311.1

{b)./erEjBu¾l 4 _: 0-aminq-3 _: methyl _: pyrazol _: 1 _r yljpiperidine- 1 -carboxylate and /er/-Butyl.4-(4 _: 4GP j.h P.:5 -methyj _-py razql - ] -y j )pj.peri dine- Ecarb ox_y 1 ate

Iron powder (2.007 g, 35.93 mmol) was added to a mixture of 2: 1 /er/-butyl 4-(3-methyl-4- nitro-pyrazol-l-yl)piperidine-l-carboxylate and /er/-butyl 4-(5-methyl-4-nitro-pyrazol-l- yl)piperidine-l-carboxylate (2.788 g, 8.98 mmol) and ammonium chloride (1.922 g, 35.93 mmol) in ethanol (22.5 mL) and water (22.5 mL). The resulting mixture was stirred at 60 °C for 1 hour. The reaction was then allowed to cool to room temperature and diluted with DCM (100 mL). The resulting suspension was filtered through Celite and rinsed with DCM and water. The resulting filtrate was transferred to a separatory funnel, and the layers were separated. The aqueous layer was extracted twice with DCM (50 mL), and the combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated to afford a 2:1 mixture of /er/-butyl 4-(4-amino-3-methyl-pyrazol-l-yl)piperidine-l- carboxylate and fe/V-butyl 4-(4-amino-5-methyl-pyrazol-l-yl)piperidine-l-carboxylate (2.55 g, quantitative) as a dark red -brown oil. m/r. (ES+), [M+H]+ = 281.5

£cJ.M_ethy_l__3 :£[_] -( j_-Cy;/-butq_xy_c_arbqnyJ_ _: _4-p_iperi_dyJ_)_-3 _: m_et_hyJ-pyrazqJ_-4 _: yJ_]ami_nqJ _: _6-chlqrq-

_. 5-cydoprqpyl-pyrarine-2 ₇ carbqxyJate and methyl 3-[[l _T ( l -/ _t y7 _T butoxycarbonyL-4:piperidyl)-

_. 5- _. rnethyl-pyrazo!-4 ₇ yl}amino]-6 _r chlqro _r 5-cycloprqpyl _T pyrazine-2 _: carboxylate DIPEA (850 μL, 4.88 mmol) was added to a solution of methyl 6-chloro-5-cyclopropyl-3- fluoro-pyrazine-2-carboxylate (375 mg, 1.63 mmol) and 2: 1 tert- butyl 4-(4-amino-3-methyl- pyrazol-l-yl)piperidine-l-carboxylate and /er/-butyl 4-(4-amino-5-methyl-pyrazol-l- yl)piperidine-l-carboxylate (912 mg, 3.25 mmol) in DMF (7.3 mL). The resulting mixture was allowed to stir at 100 °C for 2 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 5% MeOH-DCM as eluent, and 0 to 0.1% methanolic ammonia as modifier, to afford a 55:45 mixture of methyl 3-[[ 1 -( 1 -tert- butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4-yl]amino]-6-c hloro-5-cyclopropyl-pyrazine- 2-carboxylate and methyl 3-[[l-(l-/er/-butoxycarbonyl-4-piperidyl)-5-methyl-pyrazol-4 - yl]amino]-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate (0.804 g, quantitative) as brown solid. ¾ NMR (500 MHz, Chloroform-d): d 1.00 - 1.16 (2H, m), 1.16 - 1.27 (2H, m), 1.47 - 1.51 (11H, m), 1.82 - 1.93 (2H, m), 2.09 - 2.18 (2H, m), 2.23 - 2.34 (3H, m), 2.44 - 2.61 (1H, m), 3.94 - 4.01 (3H, m), 4.07 - 4.49 (3H, m), 7.71 - 7.85 (1H, m), 9.37 - 9.85 (1H, m). m/r (ES+), [M+H]+ = 491.2

{¾ _. Methyl _. 3_-[Ll-(l-7er/-butoxycarbonyl-4-piperidyl)-3-methyl _: pyrazql:4 _r yl]amino]-5- cyclppropyl-6-Q-methylbenziinidazol _: 4-yl)pyrazine _: 2-carboxylate.and.methyl 3 _: £[l-(l _: /er/- i?utpxy.carbonyl _:: 4 _: piperidyl) _: 5-inethyl.-pyrazol-4-yllamino]-5 _: cyclppropyl-6-(_l-_ methylbenzimidazgl-4:yl)pyrazine-2-carbpxylate

A mixture of l-methyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benz imidazole (841 mg, 3.26 mmol), 55:45 methyl 3-[[l-(l-/er/-butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4 - yl]amino]-6-chloro-5-cyclopropyl-pyrazine-2-carboxylate and methyl 3-[[l-(l -tert- butoxycarbonyl-4-piperidyl)-5-methyl-pyrazol-4-yl]amino]-6-c hloro-5-cyclopropyl-pyrazine- 2-carboxylate (800 mg, 1.63 mmol), Pd(dppf)Ch dichloromethane adduct (133 mg, 0.160 mmol), and cesium fluoride (743 mg, 4.89 mmol) was evacuated and backfilled three times with nitrogen. 1,4-Dioxane (14.8 mL) and water (1.5 mL) were added. The resulting slurry was evacuated and backfilled three times with nitrogen, then stirred at 80 °C for 21 hours. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 5% MeOH-DCM as eluent, and 0 to 0.1% methanolic ammonia as modifier, to afford a 60:40 mixture of methyl 3-[[l-(l-/er/-butoxycarbonyl-4-piperidyl)-3- methyl-pyrazol-4-yl]amino]-5-cyclopropyl-6-(l-methylbenzimid azol-4-yl)pyrazine-2- carboxylate and methyl 3-[[l-(l-/er/-butoxycarbonyl-4-piperidyl)-5-methyl-pyrazol-4 - yl]amino]-5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)pyrazin e-2-carboxylate (0.655 g,

69% yield) as an orange oil. ¾ NMK (500 MHz, Chloroform-d): d 0.77 - 1.00 (2H, m), 1.20

- 1.40 (2H, m), 1.47 (9H, br d), 1.80 - 2.04 (3H, m), 2.26 - 2.37 (3H, m), 2.89 (2H, br d), 3.81

- 3.89 (3H, m), 3.93 (3H, br dd), 4.06 - 4.46 (3H, m), 7.36 - 7.48 (3H, m), 7.87 (1H, br dd), 7.88 - 8.00 (1H, m), 9.50 - 9.91 (1H, m). 2 protons were buried under a pinacol impurity peak. m/r (ES+), [M+H]+ = 586.6

_. (e) Methyl _. 5:Cyclopropyl-6:(l _: methylbenzimidazol-4-yl)-3 _: X[3 -methyl- 1 _: (4- p(peridyJ)_p_y_razol-4-yJ)ami_no]pyrazi_ne _: _2-carboxyJ_ate and rne_thyl__5 _: _cy_cj_opropyj-6-(_[_- methylbenzimidazgl-4 _: yl) _: 3-[L5-methyl-l _: .(4 _: piperidyl).pyrazol-4-yllamino]pyrazine _: 2- carbpxylate

4 M HC1 in 1,4-dioxane (5.60 mL, 22.3 mmol) was added to a 60:40 mixture of methyl 3-[[l- (1 -/<2/7-butoxycarbonyl-4-piperidyl)-3-methyl-pyrazol-4-yl] amino]-5-cyclopropyl-6-( l - methylbenzimidazol-4-yl)pyrazine-2-carboxylate and methyl 3-[[ 1 -(1 -/<3/7-butoxy carbony 1-4- pi peri dyl)-5-methyl -pyrazol-4-yl ]amino]-5 -cyclopropyl -6-( l -methylbenzimidazol-4- yl)pyrazine-2-carboxylate (655 mg, 1.12 mmol). The resulting mixture was stirred at room temperature for 2 hours. The reaction was then concentrated to afford a 60:40 mixture of methyl 5-cyclopropyl-6-(l -methylbenzimidazol-4-yl)-3-[[3 -methyl- l-(4-piperidyl)pyrazol -4- yl]amino]pyrazine-2-carboxylate hydrochloride and methyl 5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)-3-[[5-methyl-l-(4-piperidyl)pyrazol -4-yl]amino]pyrazine-2- carboxylate hydrochloride (0.584 g, quantitative). m/z\ (ES+), [M+H]+ = 486.7 {0.M.Qthyl.5-c _j cJ.opropyJ.-6-(l-methylbenzimidazol _: 4-yl)-3-[^3 _: methyl _: l-(l -methyl-4- piperidyJ)_p_yrazol-4-yJ2ami_no]pyrazi_ne _: _2-cnAoxyJ_ate and_me_thyJ__5 _: _cy_cj_opropyj-6-(_l_- f0ethylbenzimidazol-4 _T yl) _: 3-[l(5-methyJ-l _: (l _: rriethyJ _: 4-piperidyJ)pyrazoJ-4- ylJaminp] _. pyrazine-2-carbgxylate

DIPEA (488 μL, 2.79 mmol) was added to a 60:40 mixture of methyl 5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(4-piperidyl)pyrazol -4-yl]amino]pyrazine-2- carboxylate hydrochloride and methyl 5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[5- methyl-l-(4-piperidyl)pyrazol-4-yl]amino]pyrazine-2-carboxyl ate hydrochloride (584 mg,

1.12 mmol) in DMF (4.60 mL). The resulting solution stirred at room temperature for 5 minutes. 37% aqueous formaldehyde (500 μL, 6.70 mmol) and a few drops of acetic acid were added sequentially. Sodium triacetoxyborohydride (710 mg, 3.35 mmol) was added portionwise as a solid. The resulting mixture was allowed to stir at room temperature for 15 min. The reaction was then diluted with water and concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 10% MeOH-DCM as eluent, and 0 to 0.2% methanolic ammonia,, to afford a 60:40 mixture of methyl 5-cyclopropyl-6-(l- methylbenzimidazol-4-yl)-3-[[3-methyl-l-(l-methyl-4-piperidy l)pyrazol-4- yl]amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3- [[5-methyl-l-(l-methyl-4-piperidyl)pyrazol-4-yl]amino]pyrazi ne-2-carboxylate (0.448 g, 80% yield) as a yellow solid. 'H NMR (500 MHz, Chloroform-d). m/z: (ES+), [M+H]+ = 501.4 ig).5rCydpprgpyl-6-(l _: methylbenzimidazol-4-yl) _: 3-[[3-methyl-l _: .(l _: methyl _: 4- pip.?ridyl).p.yrazol-4-yliamino]pyrazine _: 2_-carbpxamide and 5-cyclpprgpyl-6-(l- methylbenzimidazgl-4:yl) _: 3-[L5-methyl-l:(l _: methyl _: 4-piperidyl)pyrazol-4- ylJ¾rning] _. pyrazine-2-carbgxamide

7 N Methanolic ammonia (6.3 mL, 44 mmol) was added to a 60:40 mixture of methyl 5- cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[3-methyl-l-(l- methyl-4-piperidyl)pyrazol-4- yl]amino]pyrazine-2-carboxylate and methyl 5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3- [[5-methyl-l-(l-methyl-4-piperidyl)pyrazol-4-yl]amino]pyrazi ne-2-carboxylate (440 mg, 0.88 mmol). The resulting mixture was stirred at 100 °C for 1 hour in a Biotage microwave reactor. The reaction was then concentrated. The resulting residue was purified by silica gel chromatography, using 0 to 20% MeOH-DCM as eluent, and 0 to 0.4% methanolic ammonia as modifier, to afford a yellow film. This material was further purified by preparative SFC, using a 5 micron, 21 mm x 250 mm ChiralPak IJ column, isocratic 20% MeOH-sCCh as eluent, and 0.2% ammonium as modifier, to afford 5-cyclopropyl-6-(l-methylbenzimidazol-4- yl)-3-[[3-methyl-l-(l-methyl-4-piperidyl)pyrazol-4-yl]amino] pyrazine-2-carboxamide (115 mg, 27% yield) as a yellow solid and 5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[5- methyl-l-(l-methyl-4-piperidyl)pyrazol-4-yl]amino]pyrazine-2 -carboxamide (88 mg, 21% yield) as a yellow solid.

5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[3-methyl- l-(l-methyl-4-piperidyl)pyrazol-

4-yl]amino]pyrazine-2-carboxamide: ¹ H NMR (500 MHz, DMSO-d6): d 0.82 - 0.94 (2H, m), 1.01 - 1.12 (2H, m), 1.79 - 1.93 (3H, m), 1.96 - 2.09 (4H, m), 2.19 (6H, s), 2.83 (2H, br d), 3.87 (3H, s), 3.95 - 4.06 (1H, m), 7.31 - 7.44 (2H, m), 7.64 (1H, br d), 7.73 (1H, br s), 7.91 (1H, br s), 7.99 (1H, s), 8.20 (1H, s), 10.74 (1H, s). m/z\ (ES+), [M+H]+ = 486.4

5-cyclopropyl-6-(l-methylbenzimidazol-4-yl)-3-[[5-methyl- l-(l-methyl-4-piperidyl)pyrazol- 4-yl]amino]pyrazine-2-carboxamide: ¹ H NMR (500 MHz, DMSO-d6): d 0.78 - 0.88 (2H, m), 0.94 - 1.04 (2H, m), 1.79 (2H, br s), 1.83 - 1.91 (1H, m), 1.97 - 2.10 (4H, m), 2.20 (3H, s), 2.26 (3H, s), 2.86 (2H, br d), 3.87 (3H, s), 4.01 - 4.14 (1H, m), 7.31 - 7.43 (2H, m), 7.63 (1H, br d), 7.71 (1H, br s), 7.79 (1H, s), 7.89 (1H, br s), 8.19 (1H, s), 10.58 (1H, s). m/z\ (ES+), [M+H]+ = 486.4