SUBSTITUTED PYRIDINONE DERIVATIVES AND METHODS FOR MANUFACTURING THE SAME

WIPO Patent Application WO/2012/011707

A3

Disclosed are a novel compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and the compound-containing pharmaceutical composition for treating a metabolic disorder. Specifically, the disclosed compound is represented by [Formula 1]. The compound activates GPR119, and thus can be used for treating metabolic disorders, that is, diabetes mellitus, diabetes mellitus-related diseases, diabetes mellitus-related microvessel complications, diabetes mellitus-related large vessel complications, cardiovascular disorders, metabolic syndrome and its constituent diseases, obesity, and other diseases. In Formula 1, P1, P2, P3, P4, L1, R4, n4, X, Y, Z1 and Z2 are the same as defined above.

PARK YONG KYU (KR)
BANG SUNG HUN (KR)
KIM JIN WOONG (KR)
LEE HAN KYU (KR)
KIM JAE HYUN (KR)
SON CHANG MO (KR)
LEE JUN HEE (KR)
SHIN CHANG YONG (KR)
LEE JONG CHAN (KR)
RHEE JAE KEOL (KR)

PCT/KR2011/005268

May 31, 2012

July 18, 2011

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HYUNDAI PHARM CO LTD (KR)
PARK YONG KYU (KR)
BANG SUNG HUN (KR)
KIM JIN WOONG (KR)
LEE HAN KYU (KR)
KIM JAE HYUN (KR)
SON CHANG MO (KR)
LEE JUN HEE (KR)
SHIN CHANG YONG (KR)
LEE JONG CHAN (KR)
RHEE JAE KEOL (KR)

C07D401/14; A61K31/444; A61P3/00; C07D401/12

US20090286812A1	2009-11-19
US20090018055A1	2009-01-15

HA OVERTON ET AL.: "GPR119, a novel G protein receptor target for the treatment of type 2 diabetes and obesity", BRITISH JOURNAL OF PHARMACOLOGY, vol. 153, 2008, pages S76 - S81, XP002544526, DOI: doi:10.1038/sj.bjp.0707529

KIM, Moon Jae (41-3 Seosomun-dong, Jung-gu, Seoul 100-813, KR)

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