SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS

WIPO Patent Application WO2001047878

A8

The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R<1>=H, a C 1-10-alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br-, C1 or OH radical bound by a C 1-6 alkylene group, R<2>=CH(R<4>)N(R<5>)(R<6>), R3, R3', R3'' identically or individually represent H, F, C1, Br, CF3, CN, NO2, SO2NH2, NHR<7>,SR<8>, OR<9>, CO(OR<10>), CH<2>CO(OR<11>), COR<15>, a C 1-10-alkyl-, aryl-, heteroaryl- aryl radical or a heteroalkyl radical bound by a C 1-6 alkylene group, R<4> = an unsubstituted phenyl radical or a phenyl radical substituted at least with C 1-4 alkyl, C 1-3-alkoxy-, halogen-, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migranes, narcolepsy, overweight, asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsia, anxiolysis, increasing vigilance and/or increasing libido.

GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)

PCT/EP2000/012976

October 04, 2001

December 20, 2000

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GRUENENTHAL GMBH (DE)
GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)

A61K31/401; A61K31/4453; A61K31/5377; A61P1/04; A61P1/12; A61P3/04; A61P9/00; A61P11/06; A61P13/02; A61P25/04; A61P25/06; A61P25/14; A61P25/20; A61P25/22; A61P25/24; A61P25/32; A61P27/06; A61P29/00; A61P37/08; C07D207/00; C07D207/335; C07D401/06; C07D405/04; C07D407/04; C07D207/32; (IPC1-7): C07D207/00

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