Title:
SUBSTITUTED SPIROBENZAZEPINES
Document Type and Number:
WIPO Patent Application WO2005037795
Kind Code:
A3
Abstract:
The invention is directed to nonpeptide substituted benzazepines of Formula (I), which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension, among others disclosed. Pharmaceutical compositions comprising a compound of Formula (I) and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
Inventors:
PATEL MONA (US)
RYBCZYNSKI PHILIP J (US)
XIANG MIN AMY (US)
RYBCZYNSKI PHILIP J (US)
XIANG MIN AMY (US)
Application Number:
PCT/US2004/019460
Publication Date:
July 28, 2005
Filing Date:
June 16, 2004
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
PATEL MONA (US)
RYBCZYNSKI PHILIP J (US)
XIANG MIN AMY (US)
PATEL MONA (US)
RYBCZYNSKI PHILIP J (US)
XIANG MIN AMY (US)
International Classes:
C07C205/57; C07D223/32; (IPC1-7): C07D223/00; A61K31/55; A61P9/00
Domestic Patent References:
| WO2002002531A1 | 2002-01-10 |
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