Statement of Related Application The present application claims priority under 35 USC 119 from US Provisional Patent Application Serial No. 60/563,882, filed April 20, 2004, entitled "Substituted Heteroaryl Derivatives As Therapeutic Agents", the entirety of which is herein incorporated by reference. Field of the Invention This invention relates to substituted heteroaryl derivatives, compositions, and methods of treatment using the compounds and compositions which may be useful for the management, treatment, control, or adjunct treatment of diseases which may be responsive to the modulation of a melanocortin receptor. Background of the Invention The neuroendocrine regulation of homeostasis of body weight and energy expenditure is achieved by integrating peripheral hormonal signals such as leptin and insulin, and central signals generated from hypothalamic regions including the arcuate nucleus, mediobasal nucleus and paraventricular nucleus (Woods S.C., et al., 1998, "Signals that regulate food intake and energy homeostasis", Science, 280:1378 -1383; Flier J.S., et al., 1998, "Obesity and the hypothalamus: novel peptides for new pathways", Cell, 92:437- 440). Within the neuroendocrine regulatory pathway, the melanocortin system of the arcuate nucleus is of major importance. Melanocortin receptors (MC-R) have been identified in these hypothalamic regions. Proopiomelanocortin (POMC) containing neurons project to the arcuate nucleus to provide multiple neuropeptide neurotransmitters to stimulate these receptors. MC-Rs belong to the G-protein coupled receptor (GPCR) superfamily that contains a seven transmembrane structure. One unique characteristic that differentiates MC-Rs from other GPCRs is that endogenous antagonists/inverse agonists for these receptors have been discovered. Striking evidence of endogenous antagonists/inverse agonists for MC-Rs has emerged from studies of the agouti protein, which exerts its effects through interacting with MC-R with competitive antagonism of the natural ligand alpha-MSH (Bultman SJ, et al. 1992 "Molecular characterization of the mouse agouti locus", Cell, 71:1195-1204; Lu, D., et al., 1994, "Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor", Nature, 371:799 -802; Brash G., 1999 "From the agouti protein to POMC-100 years of fat blonde mice", Nat. Med., 5:984 -985). The discovery of Agouti-related peptide (AgRP), an agouti protein homologue, that interacts specifically with subtypes of MC-Rs (MC-3R and MC-4R) and antaqonizes MC-4R but not MC-1 R further suggests that the central MC-R are involved in body weight regulation. (Ollmann, M. M.,' et al., 1997, "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein", Science, 278:135-138). Five subtypes of MC-R (MC-1 R - MC-5R) have been identified. Multiple POMC peptides are agonists on these receptors with overlapping activity (Adan Rah, et al., 1994, "Differential effects of melanocortin peptides on neural melanocortin receptors", MoI Pharmacol., 46:1182-1190). MC-1 R is primarily located in the peripheral nervous system. ACTH is the endogenous agonist for MC-2R, but is without much activity on other MC-R subtypes (Schioth HB, et al., 1997, "The melanocortin 1 , 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of α-MSH", Endocrinology, 155:73-78). MC-3R and MC-4 and -5 are mainly located in the CNS, with high concentrations in the hypothalamic regions such as the arcuate nucleus and paraventricular nucleus (Mountjoy K.G., et al., 1994, "Localization of the melanocortin-4 receptor (MC-4R) in neuroendocrine and autonomic control circuits in the brain", MoI Endocrinol.. 8:1298 -1308). Multiple lines of evidence indicate that hypothalamic MC-4R and MC-3R play a key role in regulating food intake and energy balance. Ectopically expressing Agouti peptide Avy mouse causes a lethal syndrome characterized by pronounced obesity and the development of diabetes and neoplasms (Lu, D., et al., 1994, "Agouti protein is an antagonist of the melanocyte stimulating-hormone receptor", Nature, 371 :799 -802). Transgenic mice over-expressing AgRP are obese, suggesting that blocking MC-3R or MC-4R is the cause of obesity. Further determination that MC-4R knock out mice (Brash, G., 1999 "From the agouti protein to POMC-100 years of fat blonde mice", Nat Med.. 5:984 -985; Huszar, D., et al., 1997 "Targeted disruption of the melanocortin-4 receptor results in obesity in mice", CeJi, 88:131- 141 ) have a similar phenotype as that of AgRP over-expressing mice further confirms that MC-4R is a key component in the body weight regulation pathway whereas MC-3R seems to be more involved in energy regulation. Deficient synthesis of melanocortins causes obesity in human and mutant mice (Krude, H., et al., 1998, ""Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans", Nat Genet. 19:155-157; Yaswen L, et al., 1999, "Obesity in the mouse model of proopiomelanocortin deficiency responds to peripheral mela-nocortin", Nat. Med., 5:1066 -1070). Moreover, in animal models of obesity treatment with αMSH like agonist induced weight loss (Benoit S. C, et al., 2000, "A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences", J NeuroscL. 20:3442-3448). In humans, mutations of the MC-4R have been identified in obese patients and linked to impaired ligand binding and signaling (Hinney, A., et al., 1999, "Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans", J. Clin. Endocrinol. Metab., 84:1483-1486; Gu, W., et al., 1999, "Identification and functional analysis of novel human melanocortin-4 receptor variants", Diabetes. 48:635- 639; Krude, H., et al., 1998, "Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans", Nat Genet. 19:155-157). Aberrant regulation of body weight, such as that in obese patients, is associated with physiological and psychological disorders. Therefore, it is desirable to find drugs that can regulate central melanocortin system and therefore treat related medical disorders. Here, we report the finding of compounds that can modulate MC-R/AgRP/αMSH system. Summary of the Invention This invention provides substituted heteroaryl derivatives and compositions which modulate the functional interaction of AgRP (Agouti related protein) with a melanocortin receptor. In an embodiment, the present invention provides compounds of Formula (I) as depicted below. In another embodiment, the present invention provides methods of preparation of compounds of Formula (I). In another embodiment, the present invention provides pharmaceutical compositions comprising the compounds of Formula (I). In another embodiment, the present invention provides methods of treatment comprising: administering to a subject a compound of Formula (I). The compounds of the invention are useful as modulators of AgRP interaction with a melanocortin receptor and thus may be useful for the management, treatment, control and adjunct treatment of diseases or conditions that may be responsive to the modulation of one or more melanocortin receptors. Such diseases or conditions may comprise bulimia and obesity including associated dyslipidemia and other obesity- and overweight-related complications such as, for example, cholesterol gallstones, cancer (e.g., colon, rectum, prostate, breast, ovary, endometrium, cervix, gallbladder, and bile duct), menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea, as well as for a number of other pharmaceutical uses associated therewith, such as the regulation of appetite and food intake, dyslipidemia, hypertriglyceridemia, Syndrome X, type Il diabetes (non-insulin-dependent diabetes), atherosclerotic diseases such as heart failure, hyperlipidemia, hypercholesteremia, low HDL levels, hypertension, cardiovascular disease (including atherosclerosis, coronary heart disease, coronary artery disease, and hypertension), cerebrovascular disease and peripheral vessel disease. The compounds of the present invention may also be useful for treating physiological disorders related to, for example, regulation of insulin sensitivity, inflammatory response, plasma triglycerides, HDL, LDL, and cholesterol levels and the like. The compounds of the present invention may also be useful for treating female sexual disfunction, male sexual disfunction, and erectile disfunction. Detailed Description Embodiments of the present invention comprise substituted heteroaryl derivatives, compositions, and methods of use. The present invention may be embodied in a variety of ways. In an first aspect, the present invention provides substituted heteroaryl derivatives as inhibitors of AgRP interaction with a melanocortion receptor which may be useful for the management and treatment of diseases and conditions associated obesity and obesity- related disorders. In another aspect, the present invention provides compounds of Formula (I):

(I) wherein m is O, 1, or 2; A is selected from the group consisting of:

O N-SO2-R2 N — C-R3 N-SO2-R3

R4 ' R2 ' R2

LJ II) N — R2 C — R2 N — H -CH2-R3

R4 ■ *4 R3

O O O O C — N — R2 C — N — H N — C — R2 N — C — R3 R4 R3 ' R4 ' R2

_SO2_N_R2 -SO2-N-H N-SO2-R2 N-SO2-R3 R4 R3 ' R4 ' R2

O 0 0 N — C — R3 N-SO2-R3 C — C — R2 C-CH2-R3 I • I I and H 1 H ' R4 ; and III) -K;

R1 is selected from the group consisting of: a) -L-D1-G1; b) -L-D-i-alkyl; c) -L-D1 -aryl; d) -L-Di-heteroaryl; e) -L-Drcycloalkyl; f) -L-Drheterocyclyl; g) -L-Drarylene-alkyl; h) -L-Dralkylene-arylene-alkyl; i) -L-Dralkylene-aryl; j) -L-Dralkylene-G-i; k) -L-D-i-rieteroarylene-G-i; I) -L-Drcycloalkylene-G^ m) -L-Drheterocyclylene-G^ and

,

R2 is selected from the group consisting of: a) -L-D1-G1; b) -L-Dralkyl; c) -L-D1 -aryl; d) -L-Drheteroaryl; e) -L-D-pcycloalkyl; f) -L-D1-heterocyclyl; g) -L-DT-arylene-alkyl; h) -L-D^alkylene-arylene-alkyl; i) -L-Di-alkylene-aryl; j) -L-Dralkylene-Gi; k) -L-Drheteroarylene-G-i; I) -L-Di-cycloalkylene-G-,;

o) -L-Di-arylene-G!; p) -L-Drarylene-alkylene-Gi; q) -L-D^alkylene-arylene-alkylene-G^ and r) -L-Di-alkylene-arylene-G!;

R3 is selected from the group consisting of: a) -alkyl; b) -L-D1-H; c) -L-D1 -alkyl; d) -L-Draryl; e) -L-Drheteroaryl; f) -L-Dralkylene-heteroaryl; g) -L-Drcycloalkyl; h) -L-D-i-heterocyclyl; i) -L-D^arylene-alkyl; j) -L-Dralkylene-arylene-alkyl; k) -L-D^alkylene-aryl; and I) -L-Drarylene-aryl;

R4 is selected from the group consisting of: a) -hydrogen; b) -alkyl; c) -L-D1-H; d) -L-Di-alkyl;

f) -L-Di-heteroaryl; g) -L-Di-cycloalkyl; h) -L-D-i-heterocyclyl; i) -L-Di-arylene-alkyl; j) -L-Di-alkylene-arylene-alkyl; k) -L-Dralkylene-aryl; and I) -L-Di-arylene-aryl;

R5 is -cycloalkyl, -heteroaryl, or -alkylene-heteroaryl;

R6 and R7 are independently selected from the group consisting of: a) -hydrogen; b) -halo; c) -alkyl; d) -L-D1-H; e) -L-D-i-alkyl; f) -L-Draryl; g) -L-Drheteroaryl; h) -L-Drcycloalkyl; i) -L-D-i-heterocyclyl; j) -L-Drarylene-alkyl; k) -L-Dralkylene-arylene-alkyl; I) -L-Dralkylene-aryl; m) -L-Drarylene-aryl; n) -L-D2-(aryl)2; and o) -L-D2-(arylene-alkyl)2; wherein at least one of R6 and R7 is not hydrogen; or

R6 and R7 may be taken together to form part of a fused carbocyclic, fused aromatic, fused heteroaromatic, fused cycloalkylaryl, fused arylcycloalkyl, fused heterocyclylaryl, fused arylheterocyclyl, fused cycloalkylheteroaryl, fused heteroarylcycloalkyl, fused heterocyclylheteroaryl, or fused heteroarylheterocyclyl rings, wherein the ring is optionally substituted 1-8 times with the group a) -halo; b) -nitro; c) -L-D1-G1; d) -L-Di-alkyl: e) -L-Draryi; f) -L-Drheteroaryl; g) -L-Drcycloalkyl; h) -L-D^heterocyclyl; i) -L-Drarylene-alkyl; j) -L-D-i-alkylene-arylene-alkyl; k) -L-D^alkylene-aryl; I) -L-Dralkylene-G-,; m) -L-Drheteroarylene-Gi; n) -L-D^cycloalkylene-G!; o) -L-Drheterocyclylene-G^ and

wherein

a) -hydrogen; b) -halo; c) -alkyl; d) -L-D1-H; e) -L-D-i-alkyl;

g) -L-D^heteroaryl; h) -L-Drcycloalkyl; i) -L-Drheterocyclyl; j) -L-Drarylene-alkyl; k) -L-Di-alkylene-arylene-alkyl; I) -L-D-i-alkylene-aryl; m) -L-D-i-arylene-aryl; n) -L-D2-(aryl)2; or o) -L-D2-(arylene-alkyl)2;

K is cycloalkyl, heterocyclyl, aryl, heteroaryl, fused cycloalkylaryl, arylcycloalkyl, fused heterocyclylaryl, fused arylheterocyclyl, fused cycloalkylheteroaryl, fused heteroarylcycloalkyl, fused heterocyclyl heteroaryl, or fused heteroarylheterocyclyl, wherein K may be optionally substituted 1-3 times with a group selected from the group consisting of: halo, nitro, and R2;

G1 is selected from the group consisting of: -CN, -SO3H, -P(O)(OH)2, -P(O)(O-alkyl)(OH), CO2H, -CO2-alkyl, -C(O)NHS(O)2-alkyl, -C(O)NHS(O)2-aryl, -C(O)NHS(O)2- heteteroaryl, -C(O)N HS(O)2-alkylene-aryl, -C(O)NHS(O)2-alkylene-heteteroaryl, - C(O)NHS(O)2-arylene-alkyl, -S(O)2NHC(O)-alkyl, -S(O)2NHC(O)-aryl, - S(O)2NHC(O)-heteteroaryl, -S(O)2NHC(O)-alkylene-aryl, -S(O)2NHC(O)-alkylene- heteteroaryl, -NHC(O)NH-SO2-alkyl, an acid isostere,

;

G2 is selected from the group consisting of: a) -hydrogen; b) -alkylene; c) -L-D1-H; d) -L-Dralkyl; e) -L-D1 -aryl; f) -L-D1 -heteroaryl; g) -L-Drcycloalkyl; h) -L-D1 -heterocyclyl; i) -L-Drarylene-alkyl; j) -L-Dralkylene-arylene-alkyl; k) -L-Dt-alkylene-aryl; and I) -L-Drarylene-aryl;

L is a direct bond, alkylene, alkenylene, alkynylene, or arylene;

D1 is selected from the group consisting of: a direct bond, -CH2-, -O-, -N(R8)-, -C(O)-, - CON(R8)-, -CON(R9)SO2-, -N(R9)C(O)-, -N(R9)CON(R8)-, -N(R8)C(O)O-, -OC(O)N(R8)-, -N(R8)SO2-, -SO2N(R8)-, -C(O)-O-, -O-C(O)-, -S-, -S(O)-, -S(O2)-, or -N(R8)SO2N(R9)-, -N=N-, and -N(R8)-N(R9)- ;

D2 is N, alkylyne, or alkenylyne;

X1 and Y1 are independently selected from the group consisting of: a direct bond, alkylene, arylene, heteroarylene, cycloalkylene, heterocyclylene, arylene-alkylene, alkylene- arylene-alkylene, and alkylene-aryl;

R8 and R9 are independently selected from the group consisting of: -hydrogen, -alkyl, -aryl, - arylene-alkyl, -alkylene-aryl, and -alkyiene-arylene-alkyl;

R10 and R11 are independently selected from the group consisting of: hydrogen, -alkyl, -L-D1- alkyl, -L- Di-aryl, -C(O)-alkyl, -C(O>aryl, -SO2-alkyl, and -SO2-aryl, or R10 and R11 may be taken together to form a ring having the formula -(CH2)m-J-(CH2)n- bonded to the nitrogen atom to which R10 and R11 are attached, wherein m and n are 0, 1 , 2, or 3, and J is selected from the group consisting of -CH2-, -0-, -S-, -S(O2)-, - C(O)-, -CON(H)-, -NHC(O)-, -NHCON(H)-, -NHSO2-, -SO2N(H)-, -C(O)-O-, -O-C(O)-, -NHSO2NH-,

R12 and R13 are independently selected from the group consisting of hydrogen, aryl, alkyl, and alkylene-aryl;

and wherein the aryl, heteroaryl, heterocyclyl, cycloalkyl, and/or alkyl group(s) in R1 - R13 and R20, G1, G2, L, X1, Y1, may be optionally substituted 1-4 times with a substituent group selected from the group consisting of a) -hydrogen; b) halogen; c) hydroxyl; d) cyano; e) carbamoyl; f) -B-alkyl; g) -B-perhaloalkyl; h) -B-cycloalkyl; i) -B-heterocyclyl; j) -B-aryl; k) -B-heteroaryl; I) -B-alkylene-heteroaryl; m) -B-alkylene-aryl; n) -B-arylene-alkyl; o) -B-perhaloalkyl; p) -B-cycloalkylene-T-R14; q) -B-alkylene-N-R14R15; r) -B-cycloalkylene-alkyl; and s) -B-alkylene-cycloalkyl; wherein B and T are independently selected from the group consisting of: direct bond, alkylene, -CH2-, -O-, -N(H), -S-, SO2-, -CON(H)-, -NHC(O)-, -NHCON(H)-, - NHSO2-, -SO2N(H)-, -C(O)-O-, -NHSO2NH, -0-S(O)2-, and -O-C(O)-; wherein Ri4 and R15 are independently selected from the group consisting of: hydrogen, heteroaryl, cycloalkyl, heterocyclyl, aryl, alkyl, -alkylene- aryl, -alkylene-heteroaryl, and -alkylene-O-aryl; or R14 and Ri5 may be taken together to form a ring having the formula - (CH2)q-J-(CH2)r- bonded to the nitrogen atom to which R14 and R15 are attached wherein q and r are independently equal to 1 , 2, 3, or 4; J comprises a direct bond, -CH2-, -0-, -S-, -S(O2)-, -C(O)-, -CON(H)-, - NHC(O)-, -NHCON(H)-, -NHSO2-, -SO2N(H)-, -C(O)-O-, -O-C(O)-, - NHSO2NH-,

OγNHR17 0^N-R18 R17 — N — ' — N — ' or — N — ;

R17 and R18 are independently selected from the group consisting of: hydrogen, cycloalkyl, heterocyclyl, aryi, heteroaryl, alkyl, -alkyene- heteroaryl, or -alkylene-aryl;

or a pharmaceutically acceptable salt, prodrug, or solvate thereof.

In an embodiment of the compound of Formula (I), the compound of Formula (I) has the formula (Ia)

(Ia).

In another embodiment of the compound of Formula (I), the compound of Formula (I) has the formula (Ib)

(Ib).

In another embodiment of the compound of Formula (I), the compound of Formula (I) has the formula (Ic)

(Ic). In another embodiment of the compound of Formula (I), the compound of Formula (I) has the formula (Id)

(Id).

In another embodiment of the compound of Formula (I), A is selected from the group consisting of

O O

N—H -CH2-R3 U N K2 — C Il — N-

R3 R4 R3

O

N-SO2-R2 N—C—R3 N-SO2-R3

R4 R2 R2

O O O H -N — C — R3 N-SO2-R3 C — C — R2 and C-CH2-R3

H H ' R4 In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

In another embodiment of the compound of Formula (I), R6 is selected from the group consisting of: hydrogen, halo, alkyl, and phenyl. In another embodiment, R6 is selected from the group consisting of halo, alkyl, and phenyl.

In another embodiment of the compound of Formula (I), R7 is selected from the group consisting of: a) -L-D1 -alkyl; b) -L-D1 -aryl; c) -L-Drcycloalkyl; d) -L-Di-heterocyclyl; e) -L-Drarylene-alkyl; f) -L-Dralkylene-arylene-alkyl; g) -L-D^alkylene-aryl; h) -L-Drarylene-aryl; i) -L-D2-(aryl)2; and j) -L-D2-(arylene-alkyl)2; wherein L is a direct bond, CT6 alkylene, or phenylene; D1 is selected from the group consisting of: a direct bond, -CH2-, -O-, -C(O)-, -C(O)-O-, and -O-C(O)-.

In another embodiment of the compound of Formula (I), R7 is selected from the group consisting of: a) -L-Dralkyl; c) -L-Drcycloalkyl; d) -L-Drheterocyclyl; e) -L-Di-arylene-alkyl; f) -L-Dralkylene-arylene-alkyl; g) -L-Dralkylene-aryl; h) -L-Drarylene-aryl; i) -L-D2-(aryl)2; and j) -L-D2-(arylene-alkyl)2; wherein L is a direct bond, Cr6 alkylene, or phenylene; D1 is selected from the group consisting of: a direct bond, -CH2-, -O-, -C(O)-, -C(O)-O-, and -O-C(O)-. wherein the aryl, heterocyclyl, cycloalkyl, and/or alkyl group(s) in R7 and L may be optionally substituted 1 -4 times with a substituent group selected from the group consisting of a) -H; b) halogen; c) hydroxy I; d) cyano; e) -B-alkyl; f) -B-perhaloalkyl; g) -B-cycloalkyl; h) -B-heterocyclyl; i) -B-aryl; j) -B-heteroaryl; k) -B-alkylene-heteroaryl; I) -B-alkylene-aryl; m) -B-arylene-alkyl; n) -B-perhaloalkyl; o) -B-cycloalkylene-T-R14; p) -B-cycloalkylene-alkyl; and q) -B-alkylene-cycloalkyl; wherein B and T are independently selected from the group consisting of: direct bond, alkylene, -CH2-, and -O-; wherein R14 is selected from the group consisting of: hydrogen, heteroaryl, cycloalkyl, heterocyclyl, aryl, alkyl, -alkylene-aryl, -alkylene-heteroaryl, and -alkylene-O-aryl.

In another embodiment of the compound of Formula (I), R7 is selected from the group consisting of: a) -L-D1 -alkyl; b) -L-D1 -phenyl; c) -L-DrCs-βcycloalkyI; d) -L-Drtetrahydropyranyl; e) -L-Drphenylene-alkyl; f) -L-Dralkylene-phenylene-alkyl; g) -L-D-i-alkylene-phenyl; h) -L-Drphenylene-phenyl i) -L-D2-(phenyl)2; and j) -L-D2-(phenylene-alkyl)2; wherein L is a direct bond, d-6 alkylene, or phenylene; D1 is selected from the group consisting of: a direct bond, -CH2-, -O-, -C(O)-, -C(O)-O-, and -O-C(O)-. wherein the aryl, cycloalkyl, and/or alkyl group(s) in R7 and L may be optionally substituted 1-4 times with a substituent group selected from the group consisting of a) -H; b) halogen; c) hydroxyl; d) cyano; e) -B-alkyl; f) -B-perhaloalkyl; g) -B-cycloalkyl; h) -B-aryl; wherein B is selected from the group consisting of: direct bond, alkylene, -CH2-, and - O-.

In another embodiment of the compound of Formula (I), R6 is selected from the group consisting of: hydrogen, halo, alkyl, and phenyl; and R7 is selected from the group consisting of: phenyl, benzyloxy-phenyl, 4-biphenyl-3-yl, 4-biphenyl-4-yl, bromo-phenyl, chloro-methyl- phenyl, chloro-phenyl, cyano-phenyl, cyclohexylmethoxy-phenyl, cyclohexyloxy-phenyl, di-p- tolylmethyl, methoxy-phenyl, ethoxy-phenyl, isobutoxy-phenyl, trifluoromethoxy-phenyl, phenethyloxy-phenyl, phenoxy-phenyl, methylphenyl, isobutyl-phenyl, isopropyl-phenyl, tert- butyl-phenyl, trifluoromethyl-phenyl, dichloro-phenyl, difluoro-phenyl, dimethyl-phenyl, difluoro-phenyl, dihydroxy-phenyl, bis-trifluoromethyl-phenyl, di-tert-butyl-hydroxy-phenyl, benzoyl-phenyl, chloro-methyl-phenyl, (3-phenyl-propoxy)-phenyl, (methyl-cyclohexyloxy)- phenyl, (tert-butyl-cyclohexyloxy)-phenyl, and (tetrahydropyran-4-yloxy)-phenyl. In another embodiment of the compound of Formula (I), R6 is selected from the group consisting of: hydrogen, halo, alkyl, and phenyl; and R7 is selected from the group consisting of: (tert-butyl-phenyl)-phenyl-methyl, bis-(chloro-fluoro-phenyl)-methyl, bis-(fluoro-phenyl)- methyl, bis-(trifluoromethyl-phenyl)-methyl, naphthalen-1-yl, naphthalen-2-yl, 5,5,8,8- tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl, and 4-benzhydryl. In another embodiment of the compound of Formula (I), A is selected from the group consisting of: O O N — R1 N — R2 N-C-R1 Nl-C-R2

R4 R5 , R4 • . and Rs ' wherein R1 is selected from the group consisting of: a) -L-QrCrs-alkylene-Gi; and b) -L-D1-C3-B cycloalkylene-G^ R2 is selected from the group consisting of: a) -L-DrCrs-alkylene-G^ b) -L-D1-C3-S cycloalkylene-G!; c) -L-D1 -C1 -s-alkylene-phenylene-G! ; d) -L-DrC-ra-alkylene-phenylene-Crs-alkylene-Gi; and e) -L-Drphenylene-G!; R4 is selected from the group consisting of: a) hydrogen; b) -L-D1 -phenyl; c) -L-D1- d-4-alkylene-phenyl; d) -L-D1- C1 -4-alkylene-C3-8 cycloalkyl; e) -L-D1-C3-S cycloalkyl; f) -L-Drthienyl; and g) -L-DrCi-4-alkylene-thienyl; and R5 is selected from the group consisting of: a) -C3-β cycloalkyl; b) -thienyl; and c) -C1-4-alkylene-thienyl.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

wherein R1 is selected from the group consisting of: a) -(CHa)n-G1; and b) -Cs-r cycloalkylene-G-i; R2 is selected from the group consisting of: a) -phenyl-G^ and b) -(CH2)n-phenyl-Gi; n is 1, 2, 3, or 4; and G1 is selected from the group consisting of: -SO3H, -CO2H, -C(O)NHS(O)2-alkyl, - C(O)NHS(O)2-phenyl, -C(O)NHS(O)2-phenylene-alkyl, -C(O)NHS(O)2-pyridyl, - NHC(O)NH-SO2-alkyl, and an acid isostere.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

wherein R1 is selected from the group consisting of: a) -L-DrCrs-alkylene-G-i; and b) -L-D1-C3-S cycloalkylene-Gi; R2 is selected from the group consisting of: a) -L-DrCrs-alkylene-G^ b) -L-D1-C3-B cycloalkylene-GT; c) -L-DrCrs-alkylene-phenylene-d; d) -L-DrCrs-alkylene-phenylene-Crjj-alkylene-G!; and e) -L-Di-phenylene-Gi; R4 is selected from the group consisting of: hydrogen, isopropyl, 3-methyl-butyl, cyclopentyl, phenyl, tert-butyl-phenyl, cyano-phenyl, trifluoromethoxy-phenyl, methyl-phenyl, 4- biphenyl, 3-biphenyl, methoxyphenyl, hydroxyphenyl, chlorophenyl, dichlorophenyl, dimethoxy-phenyl, benzyl, methoxybenzyl, trifluoromethoxy-benzyl, thienyl, thien-2yl- methyl, 3-thien-2-yl-propyl, 2-thien-2-yl-ethyl, furan-2yl-m ethyl, cyclobutyl methyl, and cyclohexylmethyl; and R5 is selected from cyclopentyl, cyclohexyl, thienyl, thien-2yl-methyl, 3-thien-2-yl-propyl, and 2-thien-2-yl-ethyl.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

wherein R2 is selected from the group consisting of: a) -L-DrCi-5-alkylene-G!; b) -L-D1-C3-B cycloalkylene-Gi; c) -L-Di-Ci-3-alkylene-phenylene-G! ; d) -L-DrC-ra-alkylene-phenylene-Cra-alkylene-Gi; and e) -L-Drphenylene-G-,; R3 is selected from the group consisting of: a) -L-Drphenyl; b) -L-D1- Cr4-alkylene-phenyl; c) -L-D1- Ci-4-alkylene-C3-8 cycloalkyl; d) -L-D1 -C3-8 cycloalkyl; e) -L-D1 -thienyl; and f) -L-DrC^-alkylene-thienyl; and R4 is selected from the group consisting of: a) hydrogen; b) -L-Drphenyl; c) -L-Di- Cr4-alkylene-phenyl; d) -L-D1- Cr4-alkylene-C3-8 cycloalkyl; e) -L-D1-C3-B cycloalkyl; f) -L-D-i-thienyl; and g) -L-DrCr^alkylene-thienyl.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

wherein R2 is selected from the group consisting of: a) -(CH2Jn-G1; b) -Cs-r cycloalkylene-G^ c) -phenylene-Gi; and d) -(CH2)n-phenylene-G1; wherein n is 1 , 2, 3, or 4; R3 is selected from the group consisting of: a) -L-Drphenyl; b) -L-D1- C-ι-4-alkylene-phenyl; c) -L-D1- Cr4-alkylene-C3-8 cycloalkyl; d) -L-D1-C3-S cycloalkyl; e) -L-Di-thienyl; and f) -L-D1-C1-4-alkylene-thienyl; R4 is selected from the group consisting of: a) hydrogen; b) -L-Drphenyl; c) -L-D1- Cr4-alkylene-phenyl; d) -L-D1- C^-alkylene-C-rs cycloalkyl; e) -L-DrC3-8 cycloalkyl; f) -L-D^thienyl; and g) -L-DτCi-4-alkylene-thienyl; and G1 is selected from the group consisting of: -SO3H, -CO2H, -C(O)NHS(O)2-alkyl, - C(O)NHS(O)2-phenyl, -C(O)NHS(O)2-phenylene-alkyl, -C(O)NHS(O)2-pyridyl, - NHC(O)NH-SO2-alkyl, and an acid isostere.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of:

wherein R2 is selected from the group consisting of: a) -L-DrCrs-alkylene-G!; b) -L-D1-C3-S cycloalkylene-d; c) -L-D-i-Crs-alkylene-phenyl-Gi; d) -L-DrCrs-alkylene-phenylene-Crs-alkylene-G!; and e) -L-Drphenylene-Gi; R3 is selected from the group consisting of: isopropyl, 3-methyl-butyl, cyclopentyl, phenyl, tert-butyl-phenyl, cyano-phenyl, trifluoromethoxy-phenyl, methyl-phenyl, 4-biphenyl, 3-biphenyl, methoxyphenyl, hydroxyphenyl, chlorophenyl, dichlorophenyl, dimethoxy- phenyl, benzyl, methoxybenzyl, trifluoromethoxy-benzyl, thienyl, thien-2yl-methyl, 3- thien-2-yl-propyl, 2-thien-2-yl-ethyl, furan-2yl-methyl, cyclobutylmethyl, and cyclohexylmethyl; and R4 is selected from the group consisting of: hydrogen, isopropyl, 3-methyl-butyl, cyclopentyl, phenyl, tert-butyl-phenyl, cyano-phenyl, trifluoromethoxy-phenyl, methyl-phenyl, 4- biphenyl, 3-biphenyl, methoxyphenyl, hydroxyphenyl, chlorophenyl, dichlorophenyl, dimethoxy-phenyl, benzyl, methoxybenzyl, trifluoromethoxy-benzyl, thienyl, thien-2yl- methyl, 3-thien-2-yl-propyl, 2-thien-2-yl-ethyl, furan-2yl-methyl, cyclobutylmethyl, and cyclohexylmethyl.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of: O — C — R3

N-SO2-R2 N-SO2-R3 N-SO2-R3 R4 ' R2 ' and H wherein R2 is selected from the group consisting of: a) -L-DrCi-5-alkylene-Gi; b) -L-D1-C3-S cycloalkylene^ ; c) -L-D-I -Cπralkylene-phenyl-Gi; d) -L-D1 -C1 -s-alkylene-phenylene-Ci -3-alkylene-Gi ; and e) -L-Drphenylene-G^ R3 is selected from the group consisting of: a) -L-Drphenyl; b) -L-D1- C^-alkylene-phenyl; c) -L-D1- Cr.φ-alkylene-Cs-s cycloalkyl; d) -L-D1-C3-B cycloalkyl; e) -L-Drthienyl; and f) -L-DrC^-alkylene-thienyl; and R4 is selected from the group consisting of: a) hydrogen; b) -L-Drphenyl; c) -L-D1- d-4-alkylene-phenyl; d) -L-Dr Cr^alkylene-Cra cycloalkyl; e) -L-D1-C3-S cycloalkyl; f) -L-Drthienyl; and g) -L-DrCi-4-alkylene-thienyl.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of: O > O O • N-R2 . N — H N-C-R2 N-C-R3 N-C-R3 R4 , R3 , R4 , R2 H

N-SO2-R2 N-SO2-R3 N-SO2-R3 R4 ' R2 ■ and H wherein R2 is selected from the group consisting of: a) -(CHa)n-G1; b) -Cs-r cycloalkylene-G!; c) -phenylene-Gi;

wherein n is 1 , 2, 3, or 4; R3 is selected from the group consisting of: a) -L-D-rphenyl; b) -L-D1- Ci-4-alkylene-phenyl; c) -L-D1- C1-4-alkylene-C3-8 cycloalkyl; d) -L-D1-C3-8 cycloalkyl; e) -L-Drthienyl; and f) -L-D1-C1-4-alkylene-thienyl; R4 is selected from the group consisting of: a) hydrogen; b) -L-Drphenyl; c) -L-D1- C1-4-alkylene-phenyl; d) -L-D1- cycloalkyl; e) -L-D1-C3-S cycloalkyl; f) -L-Drthienyl; and g) -L-DrC^-alkylene-thienyl; and G1 is selected from the group consisting of: -SO3H, -CO2H, -C(O)NHS(O)2-alkyl, - C(O)NHS(O)2-phenyl, -C(O)NHS(O)2-phenylene-alkyl, -C(O)NHS(O)2-pyridyl, - NHC(O)NH-SO2-alkyl, and an acid isostere.

In another embodiment of the compound of Formula (I), A is selected from the group consisting of: 0 0 0 N-R2 N — H N-C-R2 N-C-R3 N-C-R3 R4 , R3 , R4 , R2 H

N-SO2-R2 N-SO2-R3 N-SO2-R3 R4 R2 - and H wherein R2 is selected from the group consisting of: a) -(CH2)H-G1; b) -Cs-r cycloalkylene-Gi; c) -phenylene-d; and d) -(CH2)n-phenylene-Gi; wherein n is 1, 2, 3, or 4; R3 is selected from the group consisting of: isopropyl, 3-methyl-butyl, cyclohexylmethyl, cyclopentyl, phenyl, tert-butyl-phenyl, cyano-phenyl, trifluoromethoxy-phenyl, methyl- phenyl, 4-biphenyl, 3-biphenyl, methoxyphenyl, hydroxyphenyl, chlorophenyl, dichlorophenyl, dimethoxy-phenyl, benzyl, methoxybenzyl, trifluoromethoxy-benzyl, thienyl, thien-2yl-methyl, 3-thien-2-yl-propyl, 2-thie n-2-yl-ethyl , furan-2yl-methyl, cyclobutylmethyl, and cyclohexylmethyl; R4 is selected from the group consisting of: hydrogen, isopropyl, 3-methyl-butyl, cyclohexylmethyl, cyclopentyl, phenyl, tert-butyl-phenyl, cyano-phenyl, trifluoromethoxy-phenyl, methyl-phenyl, 4-biphenyl, 3-biphenyl, methoxyphenyl, hydroxyphenyl, chlorophenyl, dichlorophenyl, dimethoxy-phenyl, benzyl, methoxybenzyl, trifluoromethoxy-benzyl, thienyl, thien-2yl-methyl, 3-thien-2-yl-propyl, 2-thien-2-yl-ethyl, furan-2yl-methyl, cyclobutylmethyl, and cyclohexylmethyl; and G1 is selected from the group consisting of: -SO3H, -CO2H, -C(O)NHS(O)2-alkyl, - C(O)NHS(O)2-phenyl, -C(O)NHS(O)2-phenylene-alkyl, -C(O)NHS(O)2-pyridyl, - NHC(O)NH-SO2-alkyl, and an acid isostere.

In another embodiment of the compound of Formula (I), A is selected from the group consisiting of

- flC-N-R2 f Ci— N— H N- flC-R2 N- fCi-R3 R4 R3 R4 R2

-SO9-N-R, -SO2-N-H N-SO2-R2 N-SO2-R3 R4 R3 ' R4 ' R2

O O O N — C Il — R3 N-SO2-R3 C Il — H C — R2 C Il-CH2-R3 I I I ar|d H ' H ' R4

R6 is selected from the group consisting of: hydrogen, halo, alkyl, or phenyl; and R7 is selected from the group consisting of: phenyl, benzyloxy-phenyl, 4-biphenyl~3- yl, 4-biphenyl-4-yl, bromo-phenyl, chloro-methyl-phenyl, chloro-phenyl, cyano-phenyl, cyclohexylmethoxy-phenyl, cyclohexyloxy-phenyl, di-p-tolylmethyl, methoxy-phenyl, ethoxy- phenyl, isobutoxy-phenyl, trifluoromethoxy-phenyl, phenethyloxy-phenyl, phenoxy-phenyl, methylphenyl, isobutyl-phenyl, isopropyl-phenyl, tert-butyl-phenyl, trifluoromethyl-phenyl, dichloro-phenyl, difluoro-phenyl, dimethyl-phenyl, difluoro-phenyl, dihydroxy-phenyl, bis- trifluoromethyl-phenyl, di-tert-butyl-hydroxy-phenyl, benzoyl-phenyl, chloro-methyl-phenyl, (3-phenyl-propoxy)-phenyl, (methyl-cyclohexyloxy)-phenyl, (tert-butyl-cyclohexyloxy)-phenyl, (tetrahydropyran-4-yloxy)-phenyl, (tert-butyl-phenyl)-phenyl-methyl, bis-(chloro-fluoro- phenyl)-methyl, bis-(fluoro-phenyl)-methyl, bis-(trifluoromethyl-phenyl)-methyl, naphthalen-1- yl, naphthalen-2-yl, 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl, and 4-benzhydryl. In an further embodiment, R7 is selected from the group consisting of: phenyl, bromo-phenyl, chloro-methyl-phenyl, chloro-phenyi, cyano-phenyl, di-p-tolylmethyl, methoxy-phenyl, ethoxy-phenyl, isobutoxy-phenyl, trifluoromethoxy-phenyl, methylphenyl, isobutyl-phenyl, isopropyl-phenyl, tert-butyl-phenyl, trifluoromethyl-phenyl, dichloro-phenyl, difluoro-phenyl, dimethyl-phenyl, difluoro-phenyl, dihydroxy-phenyl, bis-trifluoromethyl-phenyl, di-tert-butyl- hydroxy-phenyl, chloro-methyl-phenyl, (tert-butyl-phenyl)-phenyl-methyl, bis-(chloro-fluoro- phenyl)-methyl, bis-(fluoro-phenyl)-methyl, bis-(trifluoromethyl-phenyl)-methyl, naphthalen-1- yl, naphthalen-2-yl, and 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl. In the compounds of Formula (I), the various functional groups represented should be understood to have a point of attachment at the functional group having the hyphen. In other words, in the case Of -C1-6 alkylaryl, it should be understood that the point of attachment is the alkyl group; an example would be benzyl. In the case of a group such as - C(O)-NH-C1-6 alkylaryl, the point of attachment is the carbonyl carbon. When any variable occurs more than one time in any one constituent (e.g., R10 ), or multiple constituents (e.g. L, D1, etc.) its definition on each occurrence is independent at every other occurrence. Also, combinations of substituents and variables are permissible only if such combinations result in stable compounds. Lines. drawn into the ring systems from substituents indicate that the indicated bond may be attached to any of the substitutable ring carbon atoms. If the ring system is polycyclic, it is intended that the bond be attached to any of the suitable carbon atoms on the proximal ring only. Also included within the scope of the invention are the individual enantiomers of the compounds represented by Formula (I) above as well as any wholly or partially racemic mixtures thereof. The present invention also covers the individual enantiomers of the compounds represented by the Formula above as mixtures with diastereoisomers thereof in which one or more stereocenters are inverted. In another aspect, the present invention provides a pharmaceutically acceptable salt, prodrug, or solvate of compounds of Formula (I). In an embodiment, the prodrug comprises a biohydrolyzable ester or biohydrolyzable amide of a compound of Formula (I). Examples of compounds of Formula (I) or salts thereof having potentially useful biological activity are listed by name below in Table 1. The ability of compounds Formula (I) to inhibit AgRP interaction with MC-4R was established with representative compounds of Formula (I) listed in Table I using the assay described below. The compounds of Formula (I) in Table I showed an increase in cAMP production and a reduction in fluorescence polarization in the assay and posess an effective concentration for half maximal effect (EC50) in the assay of less than 15 μM. Compounds that inhibit AgRP functional interaction with a melanocortion receptor are potentially useful in treating diseases or conditions that may be responsive to the modulation of melanocortin receptors. The compounds of Formula (I) of the present invention may therefore be potentially useful in the treatment of obesity and obesity-related disorders. The compounds of this invention may also potentially be useful in prevention of weight gain.

Table 1

103 3-({4-[Bis-(3-chloro-4-fluoro-phenyl)- methyl]-thiazol-2-yl}-cyclopentyl-amino)- propionic acid Hydrochloride

104 3-({4-[Bis-(4-trifluoromethyl-phenyl)- methyl]-thiazol-2-yl}-cyclopentyl-amino)- propionic acid

105 3-[Cyclopentyl-(4-di-p-tolylmethyl-thiazol- 2-yl)-amino]-propionic acid Hydrochloride

106 Sodium 2-({cyclopentyl-[4-(4-isopropyl- phenyl)-thiazol-2-yl]-amino}-methyl)- benzoate

107 Sodium 2-({[4-(4-isopropyl-phenyl)- thiazol-2-yl]-thiophen-2-ylmethyl-amino}- methyl)-benzoate

108 Sodium 3-({[4-(4-isopropyl-phenyl)- thiazol-2-yl]-thiophen-2-ylmethyl-amino}- methyl)-benzoate

i no}-

Incomplete valences for heteroatoms such as oxygen and nitrogen in the chemical structures listed in Table 1 are assumed to be completed by hydrogen. In another aspect, the present invention comprises a pharmaceutical composition comprising the compound of Formula (I) and one or more pharmaceutically acceptable j carriers, excipients, or diluents. j As used herein, the term "lower" refers to a group having between one and six carbons. As used herein, the term "alkyl" refers to a straight or branched chain hydrocarbon having from one to ten carbon atoms. The term "alkylene" refers to a straight or branched chain divalent hydrocarbon radical having from one to ten carbon atoms. The term "alkyline" refers to a straight or branched chain trivalent hydrocarbon radical having from one to ten carbon atoms. Alkyl, alkylene, and alkyline groups may be optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an "alkyl", "alkylene", or "alkyline" group may containing one or more O, S, S(O), or S(O)2 atoms. Examples of "alkyl" as used herein include, but are not limited to, methyl, n-butyl, t-butyl, n-pentyl, isobutyl, and isopropyl, and the like. Examples of "alkylene" as used herein include, but are not limited to, methylene, ethylene, and the like. Examples of "alkyline" as used herein include, but are not limited to, methine, 1,1 ,2-ethyline, and the like. Examples of "alkyline" as used herein include, but are not limited to, methine, 1 ,1 ,2-ethyline, and the like. As used herein, the term "alkenyl" refers to a hydrocarbon radical having from two to ten carbons and at least one carbon - carbon double bond. The term "alkenylene" refers to a straight or branched chain divalent hydrocarbon radical having from two to ten carbon atoms and one or more carbon - carbon double bonds. The term "alkenyline" refers to a hydrocarbon triradical having from two to ten carbons and at least one carbon - carbon double bond. The alkenyl, alkenylene, and alkenyline groups may be optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an "alkenyl", "alkenylene", and "alkenyline" group may containing one or more O, S, S(O), or S(O)2 atoms. Examples of "alkenylene" as used herein include, but are not limited to, ethene-1 ,2- diyl, propene-1,3-diyl, and the like. Examples of "alkenyline" as used herein include, but are not limited to, 1 ,1 ,3-propene-1 ,1 ,2 -triyl, ethene 1 ,1 ,2-triyl, and the like. As used herein, the term "alkynyl" refers to a hydrocarbon radical having from two to ten carbons and at least one carbon - carbon triple bond. The term "alkynylene" refers to a straight or branched chain divalent hydrocarbon radical having from two to ten carbon atoms and one or more carbon - carbon triple bonds. The alkynyl and alkynylene groups may be optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such an "alkynyl" group may containing one or more O, S, S(O), or S(O)2 atoms. Examples of "alkynylene" as used herein include, but are not limited to, ethyne-1,2-diyl, propyne-1,3-diyl, and the like. As used herein, "cycloalkyl" refers to an alicyclic hydrocarbon group optionally possessing one or more degrees of unsaturation, having from three to twelve carbon atoms. The term "cycloalkylene" refers to an non-aromatic alicyclic divalent hydrocarbon radical having from three to twelve carbon atoms and optionally possessing one or more degrees of unsaturation. The cycloalkyl and cycloalkylene groups may be optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. "Cycloalkyl" includes by way of example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or cyclooctyl, and the like. Examples of "cycloalkylene" as used herein include, but are not limited to, cyclopropyl-1,1- diyl, cyclopropyl-1,2-diyl, cyclobutyl-1 ,2-diyl, cyclopentyl-1,3-diyl, cyclohexyl-1,4-diyl, cycloheptyl-1 ,4-diyl, or cyclooctyl-1,5-diyl, and the like. As used herein, the term "heterocyclic" or the term "heterocyclyl" refers to a three to twelve-membered heterocyclic ring. The term "heterocyclylene" refers to a three to twelve- membered heterocyclic ring diradical. The heterocyclic or heterocyclyl groups may optionally possess one or more degrees of unsaturation, and must contain one or more heteroatomic substitutions selected from S, SO, SO2, O, or N, optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Such heterocyclic or hetercyclylene may be optionally fused to one or more of another "heterocyclic" ring(s) or cycloalkyl ring(s). Examples of "heterocyclic" include, but are not limited to, tetrahydrofuran, 1 ,4-dioxane, 1 ,3- dioxane, piperidine, pyrrolidine, morpholine, piperazine, and the like. Examples of "heterocyclylene" include, but are not limited to, tetrahydrofuran-2,5-diyl, morpholine-2,3-diyl, pyran-2,4-diyl, 1 ,4-dioxane-2,3-diyl, 1,3-dioxane-2,4-diyl, piperidine-2,4-diyl, piperidine-1 ,4- diyl, pyrrolidine-1 ,3-diyl, morpholine-2,4-diyl, piperazine-1,4-diyl, and the like. As used herein, the term "aryl" refers to a benzene ring or to an optionally substituted benzene ring system fused to one or more optionally substituted benzene rings. The term "arylene" refers to a benzene ring diradical or to a benzene ring system diradical fused to one or more optionally substituted benzene rings. The aryl or arylene groups may be optionally substituted with substituents selected from the group consisting of lower alky!, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. Examples of aryl include, but are not limited to, phenyl, 2-naphthyl, 1-naphthyl, 1-anthracenyl, and the like. Examples of "arylene" include, but are not limited to, benzene-1 ,4-diyl, naphthalene-1 ,8-diyl, and the like. As used herein, the term "heteroaryl" refers to a five - to seven - membered aromatic ring, or to a polycyclic heterocyclic aromatic ring, containing one or more nitrogen, oxygen, or sulfur heteroatoms, where N-oxides and sulfur monoxides and sulfur dioxides are permissible heteroaromatic substitutions. The term "heteroarylene" refers to a five - to seven - membered aromatic ring diradical, or to a polycyclic heterocyclic aromatic ring diradical, containing one or more nitrogen, oxygen, or sulfur heteroatoms, where N-oxides and sulfur monoxides and sulfur dioxides are permissible heteroaromatic substitutions. The heteroaryl and heteroarylene groups may be optionally substituted with substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkylsulfenyl, lower alkylsulfonyl, oxo, hydroxy, mercapto, amino optionally substituted by alkyl, carboxy, tetrazolyl, carbamoyl optionally substituted by alkyl, aminosulfonyl optionally substituted by alkyl, acyl, aroyl, heteroaroyl, acyloxy, aroyloxy, heteroaroyloxy, alkoxycarbonyl, silyloxy optionally substituted by alkoxy, alkyl, or aryl, silyl optionally substituted by alkoxy, alkyl, or aryl, nitro, cyano, halogen, or lower perfluoroalkyl, multiple degrees of substitution being allowed. For polycyclic aromatic ring systems, one or more of the rings may contain one or more heteroatoms. Examples of "heteroaryl" used herein are furan, thiophene, pyrrole, imidazole, pyrazole, triazole, tetrazole, thiazole, oxazole, isoxazole, oxadiazole, thiadiazole, isothiazole, pyridine, pyridazine, pyrazine, pyrimidine, quinoline, isoquinoline, quinazoline, benzofuran, benzothiophene, indole, and indazole, and the like. Examples of "heteroarylene" used herein are furan-2,5-diyl, thiophene-2,4-diyl, 1 ,3,4-oxadiazole-2,5-diyl, 1 ,3,4-thiadiazole-2,5-diyl, 1 ,3-thiazole-2,4-diyl, 1 ,3-thiazole-2,5- diyl, pyridine-2,4-diyl, pyridine-2,3-diyl, pyridine-2,5-diyl, pyrimidine-2,4-diyl, quinoline-2,3- diyl, and the like. • As used herein, the term "fused cycloalkylaryl" refers to one or more cycloalkyl groups fused to an aryl group, the aryl and cycloalkyl groups having two atoms in common, and wherein the aryl group is the point of substitution. Examples of "fused cycloalkylaryl" used herein include 5-indanyl, 5,6,7,8-tetrahydro-2-naphthyl,

, and the like. As used herein, the term "fused cycloalkylarylene" refers to a fused cycloalkylaryl, wherein the aryl group is divalent. Examples include

, and the like. As used herein, the term "fused arylcycloalkyl" refers to one or more aryl groups fused to a cycloalkyl group, the cycloalkyl and aryl groups having two atoms in common, and wherein the cycloalkyl group is the point of substitution. Examples of "fused arylcycloalkyl" used herein include 1-indanyl, 2-indanyl, 9-fluorenyl, 1-(1,2,3,4-tetrahydronaphthyl),

, and the like. As used herein, the term "fused arylcycloalkylene" refers to a fused arylcycloalkyl, wherein the cycloalkyl group is divalent. Examples include 9,1-fluorenylene,

, and the like. As used herein, the term "fused heterocyclylaryl" refers to one or more heterocyclyl groups fused to an aryl group, the aryl and heterocyclyl groups having two atoms in common, and wherein the aryl group is the point of substitution. Examples of "fused heterocyclylaryl" used herein include 3,4-methylenedioxy-1 -phenyl,

As used herein, the term "fused heterocyclylarylene" refers to a fused heterocyclylaryl, wherein the aryl group is divalent. Examples include

, and the like. As used herein, the term "fused arylheterocyclyl" refers to one or more aryl groups fused to a heterocyclyl group, the heterocyclyl and aryl groups having two atoms in common, and wherein the heterocyclyl group is the point of substitution. Examples of "fused arylheterocyclyl" used herein include 2-(1 ,3-benzodioxolyl),

, and the like. As used herein, the term "fused arylheterocyclylene" refers to a fused arylheterocyclyl, wherein the heterocyclyl group is divalent. Examples include

, and the like. As used herein, the term "fused cycloalkylheteroaryl" refers to one or more cycloalkyl groups fused to a heteroaryl group, the heteroaryl and cycloalkyl groups having two atoms in common, and wherein the heteroaryl group is the point of substitution. Examples of "fused cycloalkylheteroaryl" used herein include 5-aza-6-indanyl,

, and the like. As used herein, the term "fused cycloalkylheteroarylene" refers to a fused cycloalkylheteroaryl, wherein the heteroaryl group is divalent. Examples include

, and the like. As used herein, the term "fused heteroarylcycloalkyl" refers to one or more heteroaryl groups fused to a cycloalkyl group, the cycloalkyl and heteroaryl groups having two atoms in common, and wherein the cycloalkyl group is the point of substitution. Examples of "fused heteroarylcycloalkyl" used herein include 5-aza-1-indanyl,

and the like. As used herein, the term "fused heteroarylcycloalkylene" refers to a fused heteroarylcycloalkyl, wherein the cycloalkyl group is divalent. Examples include

, and the like. As used herein, the term "fused heterocyclylheteroaryl" refers to one or more heterocyclyl groups fused to a heteroaryl group, the heteroaryl and heterocyclyl groups having two atoms in common, and wherein the heteroaryl group is the point of substitution. Examples of "fused heterocyclylheteroaryl" used herein include 1 ,2,3,4-tetrahydro-beta- carbolin-8-yl,

and the like. As used herein, the term "fused heterocyclylheteroarylene" refers to a fused heterocyclylheteroaryl, wherein the heteroaryl group is divalent. Examples include

, and the like. As used herein, the term "fused heteroarylheterocyclyl" refers to one or more heteroaryl groups fused to a heterocyclyl group, the heterocyclyl and heteroaryl groups having two atoms in common, and wherein the heterocyclyl group is the point of substitution. Examples of "fused heteroarylheterocyclyl" used herein include -5-aza-2,3- dihydrobenzofuran-2-yl,

, and the like. As used herein, the term "fused heteroarylheterocyclylene" refers to a fused heteroarylheterocyclyl, wherein the heterocyclyl group is divalent. Examples include

, and the like.

As used herein, the term "acid isostere" refers to a substituent group which will ionize at physiological pH to bear a net negative charge. Examples of such "acid isosteres" include, but are not limited to, 1 ) heteroaryl groups such as, but not limited to, isoxazol-3-ol- 5-yl, 1H-tetrazole-5-yl, or 2H-tetrazole-5-yl; 2) heterocyclyl groups such as, but not limited to, imidazolidine-2,4-dione-5-yl, imidazolidine-2,4-dione-1-yl, 1 ,3-thiazolidine-2,4-dione-5-yl, 5- hydroxy-4H-pyran-4-on-2-yl, 1 ,2,5-thiadiazolidin-3-one-1 ,1-dioxide-4-yl, 1 ,2-5- thiadiazolidin-3-one-1 ,1-dioxide-5-yl, 1,2,5-thiadiazolidin-3-one-1 ,1-dioxide-5-yl having substituents at the 2 and/or 4 position; and -N-acyl-alkylsulfonamides. As used herein, the term "direct bond", where part of a structural variable specification, refers to the direct joining of the substituents flanking (preceding and succeeding) the variable taken as a "direct bond". Where two or more consecutive variables are specified each as a "direct bond", those substituents flanking (preceding and succeeding) those two or more consecutive specified "direct bonds" are directly joined. As used herein, the term "alkoxy" refers to the group RaO-, where Ra is alkyl. As used herein, the term "alkenyloxy" refers to the group R3O-, where R3 is alkenyl. As used herein, the term "alkynyloxy" refers to the group RaO-, where R3 is alkynyl. As used herein, the term "alkylsulfanyl" refers to the group R3S-, where Ra is alkyl. As used herein, the term "alkenylsulfanyl" refers to the group R3S-, where Ra is alkenyl. As used herein, the term "alkynylsulfanyl" refers to the group RaS-, where R3 is alkynyl. As used herein, the term "alkylsulfenyl" refers to the group R3S(O)-, where R3 is alkyl. As used herein, the term "alkenylsulfenyl" refers to the group R3S(O)-, where Ra is alkenyl. As used herein, the term "alkynylsulfenyl" refers to the group R3S(O)-, where R3 is alkynyl. As used herein, the term "alkylsulfonyl" refers to the group RaS02-, where Ra is alkyl. As used herein, the term "alkenylsulfonyl" refers to the group R3SO2-, where R3 is alkenyl. As used herein, the term "alkynylsulfonyl" refers to the group R3SO2-, where R3 is alkynyl. As used herein, the term "acyl" refers to the group R3C(O)- , where R3 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or heterocyclyl. As used herein, the term "aroyl" refers to the group R3C(O)- , where R3 is aryl. As used herein, the term "heteroaroyl" refers to the group R3C(O)- , where R3 is heteroaryl. As used herein, the term "alkoxycarbonyl" refers to the group R3OC(O)-, where R3 is alkyl. As used herein, the term "acyloxy" refers to the group R3C(O)O- , where R3 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or heterocyclyl. As used herein, the term "aroyloxy" refers to the group R3C(O)O- , where R3 is aryl. As used herein, the term "heteroaroyloxy" refers to the group R3C(O)O- , where R3 is heteroaryl. As used herein, the term "optionally" means that the subsequently described event(s) may or may not occur, and includes both event(s) which occur and events that do not occur. As used herein, the term "substituted" refers to substitution with the named substituent or substituents, multiple degrees of substitution being allowed unless otherwise stated. As used herein, the terms "contain" or "containing" can refer to in-line substitutions at any position along the above defined alkyl, alkenyl, alkynyl or cycloalkyl substituents with one or more of any of O, S, SO, SO2, N, or N-alkyl, including, for example, -CH2-O-CH2-, -CH2-SO2-CH2-, -CH2-NH-CH3 and so forth. Whenever the terms "alkyl" or "aryl" or either of their prefix roots appear in a name of a substituent (e.g. arylalkoxyaryloxy) they shall be interpreted as including those limitations given above for "alkyl" and "aryl". Designated numbers of carbon atoms (e.g. C1-10) shall refer independently to the number of carbon atoms in an alkyl, alkenyl or alkynyl or cyclic alkyl moiety or to the alkyl portion of a larger substituent in which the term "alkyl" appears as its prefix root. As used herein, the term "oxo" shall refer to the substituent =0. As used herein, the term "halogen" or "halo" shall include iodine, bromine, chlorine and fluorine. As used herein, the term "mercapto" shall refer to the substituent -SH. As used herein, the term "carboxy" shall refer to the substituent -COOH. As used herein, the term "cyano" shall refer to the substituent -CN. As used herein, the term "aminosulfonyl" shall refer to the substituent -SO2NH2. As used herein, the term "carbamoyl" shall refer to the substituent -C(O)NH2. As used herein, the term "sulfanyl" shall refer to the substituent -S-. As used herein, the term "sulfenyl" shall refer to the substituent -S(O)-. As used herein, the term "sulfonyl" shall refer to the substituent -S(O)2-. -N-S(O)2- As used herein, the term "sulfamoyl" shall refer to the substituent As used herein, the term "solvate" is a complex of variable stoichiometry formed by a solute (in this invention, a compound of Formula (I)) and a solvent. Such solvents for the purpose of the invention may not interfere with the biological activity of the solute. Solvents may be, by way of example, water, ethanol, or acetic acid. As used herein, the term "biohydrolyzable ester" is an ester of a drug substance (in this invention, a compound of Formula (I) ) which either a) does not interfere with the biological activity of the parent substance but confers on that substance advantageous properties in vivo such as duration of action, onset of action, and the like, or b) is biologically inactive but is readily converted in vivo by the subject to the biologically active principle. The advantage is that, for example, the biohydrolyzable ester may be orally absorbed from the gut and transformed to (I) in plasma. Many examples of such are known in the art and include by way of example lower alkyl esters (e.g., Cr4), lower acyloxyalkyl esters, lower alkoxyacyloxyalkyl esters, alkoxyacyloxy esters, alkyl acylamino alkyl esters, and choline esters. As used herein, the term "biohydrolyzable amide" is an amide of a drug substance (in this invention, a compound of general Formula (I)) which either a) does not interfere with the biological activity of the parent substance but confers on that substance advantageous properties in vivo such as duration of action, onset of action, and the like, or b) is biologically inactive but is readily converted in vivo by the subject to the biologically active principle. The advantage is that, for example, the biohydrolyzable amide may be orally absorbed from the gut and transformed to (I) in plasma. Many examples of such are known in the art and include by way of example lower alkyl amides, α-amino acid amides, alkoxyacyl amides, and alkylaminoalkylcarbonyl amides. As used herein, the term "prodrug" includes biohydrolyzable amides and biohydrolyzable esters and also encompasses a) compounds in which the biohydrolyzable functionality in such a prodrug is encompassed in the compound of Formula (i): for example, the lactam formed by a carboxylic group in R1 and R2, and b) compounds which may be oxidized or reduced biologically at a given functional group to yield drug substances of Formula (I). Examples of these functional groups include, but are not limited to, 1 ,4- dihydropyridine, N-alkylcarbonyl-1 ,4-dihydropyridine, 1 ,4-cyclohexadiene, tert-butyl, and the like. The term "female sexual dysfunction" refers to a failure or dysfunction in female arousal, desire, reception, or orgasm which is related to disturbances or abnormality in the function of any or all of the female sexual organs. Such disturbances or abnormalities may occur spontaneously or be a by-product of disease or treatment of disease, such as cancer or surgery to treat cancers, in particular cancer of the breast or cervix. The term "male sexual dysfunction" refers to a failure or dysfunction in male sexual function, which may involve impotence, erectile dysfunction, or loss of sexual desire. The term "erectile dysfunction" refers to the failure of the male to achieve either erection and/or sexual function thereafter. "Erectile dysfunction" may be a by-product of factors such as but not limited to vascular disease, aging, surgery (particularly surgery involving organs of the male urogenital tract such as prostate), or diseases involving an imbalance of neurotransmitters or other biogenic amines or diseases involving the CNS such as depression. The present invention also provides a method for the synthesis of compounds useful as intermediates in the preparation of compounds of Formula (I) along with methods for the preparation of compounds of Formula (I). Unless otherwise indicated, variables refer to those for Formula (I). Scheme 1 illustrates a synthesis of compounds of formulae (3a) and (3b). Thiazole ring formation can be accomplished by combination of the alpha-bromoketone (1 ) and the thiourea derivative (2a) in a solvent, such as but not limited to MeOH, at a temperature of from 250C to 70 0C, to afford (3a). The intermediate (2a) may be synthesized by treatment of an amine R1R4NH with an isocyanate such as FMOC-N=C=S in a solvent such as DCM. The FMOC group may be removed by treatment of the FMOC thiourea intermediate with piperidine to afford (2a). Alternately, an intermediate K-H posessing a basic N-H group may be also reacted with a reagent FMOC-N=C=S to afford the isothiocyanate derivative, which may be analogously deprotected to afford the reagent (2b). Additionally, an intermediate K- C(O)-NH2 may be treated with a thionating reagent such as Lawessons reagent in a solvent such as toluene at a temperature of from 80 0C to 110 0C, to afford the intermediate (2b). Treatment of (2b) with (1) analogously to the above affords (3b). R6 and R7 may be taken together to constitute a heterocyclic or cycloalkyl ring system, in which case the related alpha-bromoketone serves as a suitable intermediate en route to the thiazofes (3a) and (3b).

Scheme 1

<1) (2a) (3a)

(1 ) (2b) (3b)

In one embodiment (Scheme 2), where R4 of compound (3a) is H, the nitrogen of the heteroarylamine (3c) can be sulfenylated with sulfonyl chlorides (4a) in the presence of NaH, in a suitable solvent such as THF or DMF, at a temperature of from - 30 0C to 50 0C, to afford the required compound (5a). Alternately, (3c) may be treated with (4a) in a suitable solvent such as DCM, at a temperature of from -200C to 400C, and a base such as pyridine or TEA with a catalytic amount of DMAP to afford the required sulfonamide (5a). Likewise, (3c) may be coupled with the compound (4b) where LG1 is OH, in the presence of a coupling agent such as EDC, in a solvent such as DMF, THF, or DCM, to afford the amide (5b). Where LG1 is Cl, (3c) may be treated with (4b) in the presence of NaH, in a suitable solvent such as THF or DMF, at a temperature of from - 3O0C to 50 0C, to afford the required compound (5b). Alternately, (3c) may be treated with (4b) in a suitable solvent such as DCM, at a temperature of from -200C to 400C, and a base such as pyridine or TEA with a catalytic amount of DMAP to afford the required compound (5b). In Scheme 2 R50 is a group such as but not limited to aryl, alkyl, or-alkylene-aryl, as defined for Formula I. R50 may also be another group wherein the combination -S(O)2-R5O or -C(O)-R50 meets the specification set forth for R4 in Formula (I). Scheme 2

(3c)

In another embodiment (Scheme 3), the amino group of the heteroarylamine (6) can be alkylated with a haloester (7), where (6) and (7) are treated with a base such as potassium carbonate, in a solvent such as DMF, at a temperature of from 25 0C to 130 0C, to afford the ester intermediate (7). The carboxylate protecting group can be removed under appropriate conditions; for example, if PG2 is a tert-butyl group, then treatment of (8) with an acid such as TFA or anhydrous HCI in dioxane at a temperature of from 0 0C to 30 0C furnishes the acid (9). Z1 in this instance is a group such as but not limited to an alkylene group or an alkylene-arylene group.

Scheme 3

(9) In Scheme 4, the heteroarylamine (3c) can be converted to the corresponding urea (11 ) by reaction with the sulfonyl isocyanate (10) in a solvent such as THF or DCM, at a temperature of from 0 0C to 100 0C. The reagent (9) may be prepared by treatment of soαium or potassium cyanate witn a reagent R50-SO2CI in a solvent such as THF. In this scheme R50 may be defined as in schemes 2 and 3.

Scheme 4

(3c) (10) (1 1 )

In another embodiment (Scheme 5) the secondary amine (14) can be prepared by treating (13) with the aldehyde (12) in the presence of a reducing agent such as NaCNBH3 or NaBH(OAc)3, in the presence or absence of an acid such as HCI or AcOH, in a solvent such as THF or DCM or acetic acid The resulting secondary amine (14) can be condensed with FMOC-NCS as described previously to provide the thiourea derivative (15) after the FMOC group is removed by treatment with Et2NH or piperidine. The synthesis of the aminothiazole (16) can be accomplished as in Scheme 1 , via thiourea condensation with the bromoketone and deprotection of the carboxyl protecting group PG2 to afford (16). In this scheme, R51 is a group such as substituted or unsubstituted alkyl, aryl, cycloalkyl, heteroaryl, alkylene-aryl, or alkylene-heteroaryl.

Scheme 5

In Scheme 6, a modified route can be used to synthesize N-alkyl derivatives (22). In the event, the heteroaryl amine (17) can be acylated with the carboxylic acid (18) in the presence of a coupling agent such as EDC or TFFH, in the presence or absence of a base such as NMM or DIEA, in a solvent such as DMF, THF, or DCM, to provide the amide (19). Reduction of the amide can be effected with BH3-THF to furnish the secondary amine (20). Lastly, N-alkylation of the heteroaryl amine (20) with (21) can be accomplished by treatment with NaH followed by reaction with a protected carboxyalkyl halide. Deprotection of the PG2 protecting group may be accomplished as previously described where PG2 is tert-butyl. Where PG2 is lower alkyl such as but not limited to methyl or ethyl, aqueous LiOH or NaOH treatment in the presence or absence of an organic solvent such as methanol and/or THF, followed by mild neutralization, affords the carboxylic acid (22). In this scheme R51 may have the meaning set forth previously.

Scheme 6

(20)

In Scheme 7, a heteroaromatic or aromatic ortho-mercaptoamine (23) may be treated with the reagent (24) in a solvent such as DMF or THF, at a temperature of from 0 0C to 100 0C, to afford the fused aminothiazole moiety (25). Reagent (24) may be synthesized by condensatiion of the amine R2-NH2 with CS2, in a solvent such as THF or dioxane, in the presence or absence of a base such as sodium hydride or triethylamine, at a temperature of from 00C to 60 0C, followed by quenching with methyl iodide. The aminothiazole (25) may be employed in chemistry illustrated in the Schemes above to obtain compounds of Formula (I); for example, the chemistry illustrated in Scheme 6 may be utilized to arrive at the compound (26). In Scheme 7, R52 and R53 represent optional substituents as described for aromatic rings of the present compounds of Formula (I). Ar represents an optionally substituted aryl or heteroaryl ring system such as phenyl, pyridyl, pyrimidinyl, and the like. Aminobenzothiazoles, such as compound (26) can also be prepared from the corresponding halobenzothiazoles and an appropriate amine. The reaction utilizes a metal catalyst such as, but not limited to, Pd2(dba)3 with an appropriate ligand such as, but not limited to, xantphos, BINAP or dppf. The present reaction also uses a base such as, but not limited to, Cs2CO3 at a temperature ranging from 25°C to 12O0C, in a solvent such as THF, dioxane or toluene. The resulting ester group can be hydrolyzed by using either acid using HCl in dioxane or basic conditions using NaOH to afford compound (26).

Scheme 7

(26)

In Scheme 8, the intermediate (27) where LG2 and LG3 are bromide, chloride, or iodide may be treated with the amine (28) in a solvent such as THF or DMF at a temperature of from - 20 0C to 1100C7 to obtain the possible products (29) and (30). (29) and (30) may be obtained as a mixture of products, or one product may dominate over the other, depending in the nature of the variables in (29), as well as the nature of R54 and R1. R54 may be defined as one of the variables R4, or R54 may be a protecting group PG3, preferably a protecting group that allows the nitrogen in (30) to be both nucleophilic and basic; for example, a benzyl or substituted benzyl group, such as 4-methoxybenzyl or 2,4- dimethoxybenzyl. The products (29) and (30) may be transformed to (31) and (32) via steps analogous to those performed in the above schemes. For example, the halogen groups LG2 and LG3 in (31 ) or (32) may be replaced with an aryl group by treatment of (29) or (30) with a boronic acid R55-B(OH)2 in a solvent such as THF, DME, or toluene containing aqueous base such as sodium carbonate, in the presence of a metal catalyst such as Pd(PPh3)4, thermally at a temperature of from 250C to 1100C or under microwave irradiation at a temperature of from 12O0C -170 0C. Alternately, the products (29) or (30) may be deprotected; where R54 is PG3 and PG3 is a substituted benzyl group such as 4- methoxybenzyl, treatment with a strong acid such as TFA affords the deprotected heteroaryl amine (31) where Ri is H. Compound (31) where R1 is H may be substituted according to previous Schemes to provide compounds where Ri is as in the specification for Formula (I).

Scheme 8

The synthesis of a compound of formula (36) is outlined in Scheme 9. Aldehyde (33), where W is S, may be synthesized by a multistep procedure starting with condensation of ethyl thiooxalate and a α-bromoketone in a solvent such as but not limited to MeOH. The ester group could be reduced to the aldehyde by a two-step protocol; however, compounds of this nature can also be arrived at by a one-step reduction procedure. The two-step method entails reduction with a reagent such as but not limited to LAH or LiBH4 to the alcohol, followed by oxidation employing a reagent such as but not limited to pyridinium dichromate or pyridinium chlorochromate in DCM, to the aldehyde (33). The ester group may also be converted to the aldehyde by treatment with a limiting molar amount of diisobutylaluminum hydride in a solvent such as ether, at a temperature of from -78 0C to 0 0C. Reductive amination of an amine by (33) can be accomplished as for similar operations in Scheme 5 by combining the aldehyde (33) with an amine such as but not limited to (34), in a solvent such as but not limited to DCM, to afford (35). Removal of the protecting group PG2, which in this case is a group such as tertiary butyl, may be accomplished by treatment of (35) with TFA or anhydrous HCI to afford (36).

Scheme 9

(36)

Acyl sulfonamides (Scheme 10) can be prepared from a carboxylic acid such as (37) via activation of the acid with a reagent such as but not limited to CDI or EDC in a solvent such as but not limited to THF or DMF. Treatment of the activated carboxylic acid intermediate with a sulfonamide (R56SO2NH2) in the presence of a base such as but not limited to DBU or DIEA affords the desired acyl sulfonamide (38). R56 may be a group such as but not limited to alkyl, aryl, or alkylene-aryl.

Scheme 10

N-sulfenyl ureas can be prepared (Scheme 11 ) from a carboxylic acid derivative such as (39) utilizing an acyl azide rearrangement performed by treatment of the acid (39) with a reagent such as but not limited to diphenylphosphoryl azide, in the presence of a weak base such as triethylamine, at a temperature of from - 20 0C to 250C, followed by heating at a temperature of from 250C to 1000C, followed by trapping with a sulfonamide (R56SO2NH2) to afford the N-sulfenylurea (40). R56 may be a group such as but not limited to alkyl, aryl, or alkylene-aryl. Scheme 11

Benzhydryl derivatives (Scheme 12) may be prepared by methods such as but not limited to thiazole ring synthesis (W = S) using either ethyl bromopyruvate or 3-bromo-1- phenyl-propane-1 ,2-dione and a thiourea or thioamide (as outlined in Scheme 1) in a solvent such as but not limited to MeOH. Where ethyl bromopyruvate is employed, R58 is -OC2H5, and treatment with at least 2 molar equivalents of an organometallic reagent such as an organomagnesium halide reagent R57MgX (X is Br, Cl, or I) in a solvent such as ether or THF, affords the benzhydrol intermediate. Reduction with a reagent such as triethylsilane in a solvent such as TFA or TFA/DCM mixture at a temperature of -20 0C to 25 0C affords (42). Alternately, (41) where R58 is aryl or heteroaryl may be treated with one molar equivalent of a reagent such as an organomagnesium halide reagent R57MgX (X is Br, Cl, or I) in a solvent such as ether or THF to afford the benzhydrol adduct (43). This intermediate may be reduced as described above to afford (44). In this scheme R57 may be a group such as but not limited to aryl or heteroaryl.

reduction

In the above schemes, "PGi" represents an amino protecting group. The term "amino protecting group" as used herein refers to substituents of the amino group commonly employed to block or protect the amino functionality while reacting other functional groups on the compound. Examples of such amino-protecting groups include the formyl group, the trityl group, the phthalimido group, the trichloroacetyl group, the chloroacetyl, bromoacetyl and iodoacetyl groups, urethane-type blocking groups (PG1 as used herein) such as benzyloxycarbonyl, 4-phenylbenzyloxycarbonyl, 2-methylbenzyloxycarbonyl, A- methoxybenzyloxycarbonyl, 4-fluorobenzyloxycarbonyl, 4-chlorobenzyloxycarbonyl, 3- chlorobenzyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 2,4-dichlorobenzyloxycarbonyl, A- bromobenzyloxycarbonyl, 3-bromobenzyloxycarbonyl, 4-nitrobenzyloxycarbonyl, A- cyanobenzyloxy-carbonyl, 2-(4-xenyl)iso-propoxycarbonyl, 1 ,1-diphenyleth-i-yloxycarbonyl, 1 ,1-diphenylprop-i-yloxycarbonyl, 2-phenylprop-2-yloxycarbonyl, 2-(p-toluyl)prop-2- yloxycarbonyl, cyclopentanyloxycarbonyl, 1 -methylcyclopentanyloxycarbonyl, cyclohexanyloxycarbonyl, 1-methylcyclohexanyloxycarbbnyl, 2- methylcyclohexanyloxycarbonyl, 2-(4-toluylsulfonyl)ethoxycarbonyl, 2(methylsulfonyl)ethoxycarbonyl, 2-(triphenylphosphino)ethoxycarbonyl, 9- fluorenylmethoxycarbonyl ("FMOC"), t-butoxycarbonyl ("BOC"), 2- (trimethylsilyl)ethoxycarbonyl, allyloxycarbonyl, 1 -(trimethylsilylmethyl)prop-i - enyloxycarbonyl, 5-benzisoxalylmethoxycarbonyl, 4-acetoxybenzyloxycarbonyl, 2,2,2- trichloroethoxycarbonyl, 2-ethynyl-2-propoxycarbonyl, cyclopropylmethoxycarbonyl, A- (decyloxy)benzyloxycarbonyl, isobornyioxycarbonyl, 1-piperidyloxycarbonyl and the like; the benzoylmethylsulfonyl group, the 2-(nitro)phenylsulfenyl group, the diphenylphosphine oxide group and like amino-protecting groups. The species of amino-protecting group employed is not critical so long as the derivatized amino group is stable to the condition of subsequent reaction(s) on other positions of the compound of Formula (I) and can be removed at the desired point without disrupting the remainder of the molecule. Preferred amino-protecting groups are the allyloxycarbonyl, the t-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, and the trityl groups. Similar amino-protecting groups used in the cephalosporin, penicillin and peptide art are also embraced by the above terms. Further examples of groups referred to by the above terms are described by J. W. Barton, "Protective Groups In Organic Chemistry", J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, Chapter 2, and T. W. Greene, "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, N.Y., 1981 , Chapter 7. The related term "protected amino" defines an amino group substituted with an amino-protecting group discussed above. In the above schemes, "PG2" represents carboxyl protecting group. The term "carboxyl protecting group" as used herein refers to substituents of the carboxyl group commonly employed to block or protect the -OH functionality while reacting other functional groups on the compound. Examples of such alcohol -protecting groups include the 2- tetrahydropyranyl group, 2-ethoxyethyl group, the trityl group, the methyl group, the ethyl group, the allyl group, the trimethylsilylethoxymethyl group, the 2,2,2-trichloroethyl group, the benzyl group, and the trialkylsilyl group, examples of such being trimethylsilyl, tert- butyldimethylsilyl, phenyldimethylsilyl, triiospropylsilyl and thexyldimethylsilyl. The choice of carboxyl protecting group employed is not critical so long as the derivatized alcohol group is stable to the condition of subsequent reaction(s) on other positions of the compound of the formulae and can be removed at the desired point without disrupting the remainder of the molecule. Further examples of groups referred to by the above terms are described by J. W. Barton, "Protective Groups In Organic Chemistry", J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, and T. W. Greene, "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, N.Y., 1981. The related term "protected carboxyl" defines a carboxyl group substituted with a carboxyl -protecting group as discussed above. The compounds of the present invention may be useful for the treatment of bulimia and obesity including associated dyslipidemia and other obesity- and overweight-related complications such as, for example, cholesterol gallstones, cancer (e.g., colon, rectum, prostate, breast, ovary, endometrium, cervix, gallbladder, and bile duct), menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea, as well as for a number of other pharmaceutical uses associated therewith, such as the regulation of appetite and food Intake, dyslipidemia, hypertriglyceridemia, Syndrome X, type Il diabetes (non-insulin-dependent diabetes), atherosclerotic diseases such as heart failure, hyperlipemia, hypercholesteremia, low HDL levels, hypertension, cardiovascular disease (including atherosclerosis, coronary heart disease, coronary artery disease, and hypertension), cerebrovascular disease and peripheral vessel disease. The compounds of the present invention may also be useful for treating physiological disorders related to, for example, regulation of insulin sensitivity, inflammatory response, plasma triglycerides, HDL, LDL, and cholesterol levels and the like. The compounds of the present invention may also be useful for treating female sexual disfunction, male sexual disfunction, and erectile disfunction. These conditions may be treated by modulating the functional interation of AgRP on a melanocortin receptor. Thus in another aspect, the present invention provides pharmaceutical compositions and methods of treatment. In an embodiment, the pharmaceutical compositions containing a compound of Formula (I) of the present invention may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous, or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs. Compositions intended for oral use may be prepared according to any known method, and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents, and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets may contain the active ingredient in admixture with non-toxic pharmaceutically-acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example corn starch or alginic acid; binding agents, for example, starch, gelatin or acacia; and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. They may also be coated by the techniques described in U.S. Patent Nos. 4,356,108; 4,166,452; and 4,265,874, incorporated herein by reference, to form osmotic therapeutic tablets for controlled release. In another embodiment, formulations for oral use may also be presented as hard gelatin capsules where the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or a soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil. In another embodiment, the composition may comprise an aqueous suspension. Aqueous suspensions may contain the active compounds in an admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide such as lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example, heptadecaethyl-eneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin. Also, oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as a liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alchol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid. Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active compound in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example, sweetening, flavoring, and coloring agents may also be present. The pharmaceutical compositions of the invention may also be in the form of oil-in- water emulsions. The oily phase may be a vegetable oil, for example, olive oil or arachis oil, or a mineral oil, for example a liquid paraffin, or a mixture thereof. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan monooleate, and condensation products of said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavoring agents. In another embodiment, the compositions of the present invention may comprise a syrup or elixir. Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents. The pharmaceutical compositions may be in the form of a sterile injectible aqueous or oleaginous suspension. This suspension may be formulated according to the known methods using suitable dispersing or wetting agents and suspending agents described above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example as a solution in 1 ,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conveniently employed as solvent or suspending medium. For this purpose, any bland fixed oil may be employed using synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. The compositions of the present invention may also be in the form of suppositories for rectal administration of the compounds of the invention. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will thus melt in the rectum to release the drug. Such materials include cocoa butter and polyethylene glycols, for example. In an embodiment, for topical use, creams, ointments, jellies, solutions of suspensions, etc., containing the compounds of the invention may be employed. For the purpose of this application, topical applications shall include mouth washes and gargles. In an embodiment, the compounds of the present invention may also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles, and multilamellar vesicles. Liposomes may be formed from a variety of phospholipids, such as cholesterol, stearylamine, or phosphatidylcholines. Also provided by the present invention are prodrugs of the invention. Pharmaceutically-acceptable salts of the compounds of the present invention, where a basic or acidic group is present in the structure, are also included within the scope of the invention. The term "pharmaceutically acceptable salts" refers to non-toxic salts of the compounds of this invention which are generally prepared by reacting the free base with a suitable organic or inorganic acid or by reacting the acid with a suitable organic or inorganic base. Representative salts include the following salts: Acetate, Benzenesulfonate, Benzoate, Bicarbonate, Bisulfate, Bitartrate, Borate, Bromide, Calcium Edetate, Camsylate, Carbonate, Chloride, Clavulanate, Citrate, Dihydrochloride, Edetate, Edisylate, Estolate, Esylate, Fumarate, Gluceptate, Gluconate, Glutamate, Glycollylarsanilate, Hexylresorcinate, Hydrabamine, Hydrobromide, Hydrocloride, Hydroxynaphthoate, Iodide, Isethionate, Lactate, Lactobionate, Laurate, Malate, Maleate, Mandelate, Mesylate, Methylbromide, Methylnitrate, Methylsulfate, Monopotassium Maleate, Mucate, Napsylate, Nitrate, N-methylglucamine, Oxalate, Pamoate (Embonate), Palmitate, Pantothenate, Phosphate/diphosphate, Polygalacturonate, Potassium, Salicylate, Sodium, Stearate, Subacetate, Succinate, Tannate, Tartrate, Teoclate, Tosylate, Triethiodide, Trimethylammonium and Valerate. When an acidic substituent is present, such as-COOH, there can be formed the ammonium, morpholinium, sodium, potassium, barium, calcium salt, and the like, for use as the dosage form. When a basic group is present, such as amino or a basic heteroaryl radical, such as pyridyl, an acidic salt, such as hydrochloride, hydrobromide, phosphate, sulfate, trifluoroacetate, trichloroacetate, acetate, oxlate, maleate, pyruvate, malonate, succinate, citrate, tartarate, fumarate, mandelate, benzoate, cinnamate, methanesulfonate, ethanesulfonate, picrate and the like, and include acids related to the pharmaceutically- acceptable salts listed in the Journal of Pharmaceutical Science, 66, 2 (1977) p. 1-19. In an embodiment, the present invention provides a pharmaceutical formulation comprising a hydrochloric acidic salt of a compound of Formula (I). In another embodiment, the present invention provides a pharmaceutical formulation comprising a sodium salt of a compound of Formula (I). Other salts which are not pharmaceutically acceptable may be useful in the preparation of compounds of the invention and these form a further aspect of the invention. In addition, some of the compounds of the present invention may form solvates with water or common organic solvents. Such solvates are also encompassed within the scope of the invention. Thus, in a further embodiment, there is provided a pharmaceutical composition comprising a compound of the present invention, or a pharmaceutically acceptable salt, solvate, or prodrug therof, and one or more pharmaceutically acceptable carriers, excipients, or diluents. In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, in combination with a pharmaceutically acceptable carrier and one or more hypoglycemic agents. Hypoglycemic agents may include, but are not limited to, insulin or insulin mimetics; biguanidines such as metformin or buformin; PTP-1B inhibitors; PPAR-gamma agonists; sulfonylureas such as acetohexamide, chloropropamide, tolazamide, tolbutamide, glyburide, glipizide, glyciazide; or any other insulin secretagogue such as, for example, repaglinide and nateglinide; or α-glycosidase inhibitors such as acarbose, voglibose, or miglitol; or β3-adrenoceptor agonists. In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, in combination with a pharmaceutically acceptable carrier and HMG Co-A reductase inhibitors (statins), bile acid sequestrants, fibrates such as fenofibrate, cholesterol lowering agents, inhibitors of cholesterol absorption such as ACAT inhibitors, bile acid transport inhibitors, CETP inhibitors, or other antihyperlipidemic agents to improve the lipid profile of a subject. In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, in combination with a pharmaceutically acceptable carrier and one or more agents selected from the group consisting of agents that modulate thermogenesis, lipolysis, gut motility, fat absorption, and satiety. In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, in combination with a pharmaceutically acceptable carrier and one or more agents selected from the group consisting of agents that regulate hypertension (e.g., inhibitors of angiotension converting enzyme (ACE), β-blockers, calcium channel blockers). In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, in combination with a pharmaceutically acceptable carrier and one or more agents such as; but not limited to, antiobesity agents such as fenfluramine, dexfenfluramine, sibutramine, orlistat, or β3 adrenoceptor agonists; feeding behavior modifying agents such as neuropeptide Y receptor antagonists, including those that antagonize the neuropeptide Y5 receptor; α-MSH, α -MSH mimetics, or α-MSH derived peptides; MC-4R agonists or partial agonists such as, but not limited to, those disclosed in US Patent No. 6,350,760; MC-3R agonists; glucokinase activators; PPAR-δ agonists; PPAR-α /PPAR-γ agonists; PPAR-α /PPAR-γ /PPAR-δ agonists; PPAR-γ /PPAR- δ agonists; and agents useful in treatment of male and/or female sexual disfunction, such as type V phosphodiesterase inhibitors such as sildenafil ortendamifil, dopamine agonists, or ct2-adrenoceptor antagonists. In another embodiment, the present invention provides a pharmaceutical composition comprising a compound of Formula (I), wherein the amount of the compound of Formula (I) is an amount sufficient to inhibit the function of AgRP at a melanocortin receptor. In an embodiment, the melanocortin receptor is MC-4R. In another embodiment, the melanocortin receptor is MC-3R. The term "treatment" or "treating" as used herein, refers to the full spectrum of treatments for a given disorder from which the patient is suffering, including alleviation of one, most of all symptoms resulting from that disorder, to an outright cure for the particular disorder or prevention of the onset of the disorder. For example, within the context of obesity, successful treatment may include an alleviation of symptoms or halting progression of the disease, as measured by reduction in body weight, or a reduction in amount of food or energy intake. Treatment of type I or type Il diabetes may include an alleviation of symptoms or halting progression of the disease, as measured by a decrease in serum glucose or insulin levels in, for example, hyperinsulinic or hyperglycemic subjects. The term "pharmacologically effective amount" shall mean that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, animal or human that is being sought by a researcher or clinician. A pharmaceutically effective amount includes those amounts of the compounds of Formula (I) that detectably inhibits the function of AgRP at a melanocortin receptor, for example, by the assay described below, or any other assay known or prepared by one skilled in the art. A pharmaceutically effective amount can be a therapeutically effective amount. The term "therapeutically effective amount" shall mean that amount of a drug or pharmaceutical agent that will elicit the therapeutic response of a subject that is being sought. For example, a therapeutically effective amount includes those amounts that may alleviate symptoms of a melanocortin receptor disorder, those amounts that may prevent weight gain in a subject, and those amounts that may induce weight lose in a subject. A melanocortin receptor disorder, or a melanocortin receptor mediated disease, which may be treated by the methods provided herein, include, but are not limited to, any biological disorder or disease in which a melanocortin receptor is implicated, or which inhibition of a melanocortin receptor potentiates a biochemical pathway that is defective in the disorder or disease state. Factors which may influence what constitutes a therapeutically effective amount may depend upon the size and weight of the subject, the biodegradability of the therapeutic agent, the activity of the therapeutic agent, as well as its bioavailability. As used herein, "a subject" includes mammalian subjects such as, but not limited to, humans In an embodiment, a subject is one who either suffers from one or more of the aforesaid diseases.disease states, or conditions, or are at risk for such. Accordingly, in the context of the therapeutic method of the invention, this method also is comprised of a method for treating a mammalian subject prophylactically, or prior to the onset of diagnosis such disease(s), disease state(s), or conditions. In another aspect, the present invention provides a method of treatment comprising administering to a subject a compound of Formula (I)

(D wherein m is equal to 0, 1 , or 2; A is selected from the group consisting of:

-R3

-SO2-N — R2 -SO2-N — H N-SO2-R2 N-SO2-R3 R4 R3 ■ R4 ' R2

-

; and III) -K;

R2 is selected from the group consisting of: a) -L-D1-G1; b) -L-Dralkyl; c) -L-D1 -aryl; d) -L-D-I -heteroaryl; e) -L-Drcycloalkyl; f) -L-D-rheterocyclyl; g) -L-Drarylene-alkyl; h) -L-Dralkylene-arylene-alkyl; i) -L-Dralkylene-aryl; j) -L-Dralkylene-G-,; k) -L-Drheteroarylene-Gi ; I) -L-Drcycloalkylene-G! ; m) -L-Drheterocyclylene-G! ;

o) -L-Drarylene-G!; P) -L-Drarylene-alkylene-G., ; q) -L-Dralkylene-arylene-alkylene-Gi; and r) -L-Dralkylene-arylene-Gi;

R3 is selected from the group consisting of: a) -alkyl; b) -L-D1-H; c) -L-Dralkyl; d) -L-D^aryl; e) -L-Drheteroaryl; f) -L-Dralkylene-heteroaryl; g) -L-Drcycloalkyl; h) -L-Drheterocyclyl; i) -L-Drarylene-alkyl; j) -L-Di-alkylene-arylene-alkyl; k) -L-Di-alkylene-aryl; and I) -L-Di-arylene-aryl;

R4 is selected from the group consisting of: a) -hydrogen; b) -alkyl; c) -L-D1-H; d) -L-Dralkyl; e) -L-D1 -aryl; f) -L-Drheteroaryl; g) -L-Dralkylene-heteroaryl; h) -L-Drcycloalkyl; i) -L-Drheterocyclyl; j) -L-Drarylene-alkyl; k) -L-Dralkylene-arylene-alkyl; I) -L-Dralkylene-aryl; and m) -L-Drarylene-aryl;

R6 and R7 are independently selected from the group consisting of: a) -hydrogen; b) -halo; c) -alkyl; d) -L-D1-H; e) -L-D-ralkyl; f) -L-Draryl; g) -L-Drheteroaryl; h) -L-Drcycloalkyl; i) -L-Drheterocyclyl; j) -L-Drarylene-alkyl; k) -L-Dralkylene-arylene-alkyl; I) -L-Dralkylene-aryl; m) -L-Drarylene-aryl; n) -L-D2-(aryl)2; and 0) -L-D2-(arylene-alkyl)2; wherein at least one of R6 and R7 is not hydrogen; or R6 and R7 may be taken together to form part of a fused carbocyclic, fused aromatic, fused heteroaromatic, fused cycloalkylaryl, fused aryicycloalkyl, fused heterocyclylaryl, fused arylheterocyclyl, fused cycloalkylheteroaryl, fused heteroarylcycloalkyl, fused heterocyclylheteroaryl, or fused heteroarylheterocyclyl rings, wherein the ring is optionally substituted 1-8 times with the group a) -halo; b) -nitro; c) -L-D1-G1 d) -L-Dralkyl: e) -L-Draryl; f) -L-Drheteroaryl; g) -L-Drcycloalkyl; h) -L-Drheterocyclyl; 1) -L-Drarylene-alkyl; j) -L-Dralkylene-arylene-alkyl; k) -L-Dralkylene-aryl; I) -L-Dralkylene-G^, m) -L-Drheteroarylene-G^ n) -L-Drcycloalkylene-G-i; o) -L-Drheterocyclylene-G^ and

,

wherein R20 is a) -hydrogen; b) -halo; c) -alkyl; d) -L-D1-H; e) -L-Dralkyl; f) -L-D1 -aryl; g) -L-Drheteroaryl; . h) -L-Di-cycloalkyl; i) -L-D i -heterocyclyl ; j) -L-Drarylene-alkyl; k) -L-D1 -alkylene-arylene-alkyl ; 1) -L-Dralkylene-aryl; m) -L-Drarylene-aryl; n) -L-D2-(aryl)2; or o) -L-D2-(arylene-alkyl)2;

K is cycloalkyl, heterocyclyl, aryl, heteroaryl, fused cycloalkylaryl, arylcycloalkyl, fused heterocyclylaryl, fused arylheterocyclyl, fused cycloalkylheteroaryl, fused heteroarylcycloalkyl, fused heterocyclylheteroaryl, or fused heteroarylheterocyclyl, wherein K may be optionally substituted 1-3 times with a group selected from the group consisting of: halo, nitro, and R2;

G1 is selected from the group consisting of: -CN, -SO3H, -P(O)(OH)2, -P(O)(O-alkyl)(OH), - CO2H, -CO2-alkyl, -C(O)NHS(O)2-alkyl, -C(O)NHS(O)2-aryl, -C(O)NHS(O)2- heteteroaryl, -C(O)N HS(O)2-alkylene-aryl, -C(O)NHS(O)2-alkylene-heteteroaryl, - S(O)2NHC(O)-alkyl, -S(O)2NHC(O)-aryl, -S(O)2NHC(O)-heteteroaryl, -S(O)2NHC(O)- alkylene-aryl, -S(O)2NHC(O)-alkylene-heteteroaryl, -NHC(O)NH-SO2-alkyl, an acid isostere,

G2 is selected from the group consisting of: a) -hydrogen; b) -alkylene; c) -L-D1-H; d) -L-Dralkyl; e) -L-D1 -aryl; f) -L-Drheteroaryl; g) -L-Drcycloalkyl; h) -L-Drheterocyclyl; i) -L-Drarylene-alkyl; j) -L-Dralkylene-arylene-alkyl; k) -L-D1 -alkylene-aryl; and I) -L-Drarylene-aryl;

L is a direct bond, alkylene, alkenylene, alkynylene, or arylene;

D1 is selected from the group consisting of: a direct bond, -CH2-, -O-, -N(R8)-, -C(O)-, - CON(R8)-, -CON(R9)SO2-, -N(R9)C(O)-, -N(R9)CON(R8)-, -N(R8)C(O)O-, -OC(O)N(R8)-, -N(R8)SO2-, -SO2N(R8)-, -C(O)-O-, -O-C(O)-, -S-, -S(O)-, -S(O2)-, or -N(R8)SO2N(R9)-, -N=N-, and -N(R8)-N(R9)- ;

D2"is N, alkylyne, or alkenylyne;

X1 and Y1 are independently selected from the group consisting of: a direct bond, alkylene, arylene, heteroarylene, cycloalkylene, heterocyclylene, arylene-alkylene, alkylene- arylene-alkylene, and alkylene-aryl;

R8 and R9 are independently selected from the group consisting of: -hydrogen, -alkyl, -aryl, - arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl; R10 and R11 are independently selected from the group consisting of: hydrogen, -alkyl, -L-D1- alkyl, -L- D^aryl, -C(O)-alkyl, -C(O)-aryl, -SO2-alkyl, and -SO2-aryl, or R10 and R11 may be taken together to form a ring having the formula -(CH2)m-J-(CH2)n- bonded to the nitrogen atom to which R10 and Ri1 are attached, wherein m and n are 0, 1, 2, or 3, and J is selected from the group consisting of -CH2-, -O-, -S-, -S(O2)-, - C(O)-, -CON(H)-, -NHC(O)-, -NHCON(H)-, -NHSO2-, -SO2N(H)-, -C(O)-O-, -OC(O)-, -NHSO2NH-,

R12 and Ri 3 are independently selected from the group consisting of hydrogen, aryl, alkyl, anc j alkylene-aryl; and wherein the aryl, heteroaryl, heterocyclyl, cycloalkyl, and/or alkyl group(s) in R2 - R13, and R20, Gi, G2... L, X1, Y1, may be optionally substituted 1-4 times with a substituent group selected from the group consisting of a) -hydrogen; b) halogen; c) hydroxyl; d) cyano; e) carbamoyl; f) -B-alkyl; g) -B-perhaloalkyl; h) -B-cycloalkyl; i) -B-heterocyclyl; j) -B-aryl; k) -B-heteroaryl; I) -B-alkylene-heteroaryl; m) -B-alkylene-aryl; n) -B-arylene-alkyl; o) -B-perhaloalkyl; P) -B-cycloalkylene-T-R14; q) -B-alkylene-N-R14R15; r) -B-cycloalkylene-alkyl; and s) -B-alkylene-cycloalkyl; wherein B and T are independently selected from the group consisting of: direct bond, alkylene, -CH2-, -O-, -N(H), -S-, SO2-, -CON(H)-, -NHC(O)-, -NHCON(H)-, - NHSO2-, -SO2N(H)-, -C(O)-O-, -NHSO2NH, -0-S(O)2-, and -O-C(O)-; wherein R14 and R15 are independently selected from the group consisting of: hydrogen, heteroaryl, cycloalkyl, heterocyclyl, aryl, alkyl, -alkylene- aryl, -alkylene-heteroaryl, and -alkylene-O-aryl; or R14 and R15 may be taken together to form a ring having the formula - (CH2)q-J-(CH2)r- bonded to the nitrogen atom to which R14 and R15 are attached wherein q and r are independently equal to 1 , 2, 3, or 4; J comprises a direct bond, -CH2-, -0-, -S-, -S(O2)-, -C(O)-, -CON(H)-, - NHC(O)-, -NHCON(H)-, -NHSO2-, -SO2N(H)-, -C(O)-O-, -O-C(O)-, - NHSO2NH-,

R17 OγNHR17 Oy-R18 R17 — N — ■ — N — • or — N — :

R17 and R18 are independently selected from the group consisting of: hydrogen, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl, -alkyene- ' heteroaryl, or -alkylene-aryl;

and wherein the compound of Formula (I) is as a single or polymorphic crystalline form or forms, an amorphous form, a single enantiomer, a racemic mixture, a single stereoisomer, a mixture of stereoisomers, a single diastereoisomer, a mixture of diastereoisomers, a solvate, a pharmaceutically acceptable salt, a solvate, a prodrug, a biohydrolyzable ester, or a biohydrolyzable amide thereof. In another embodiment, the present invention provides a method of treatment of an obesity-related disorder comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I). In another embodiment, the obesity-related disorder is selected from the group consisting of: dyslipidemia, hypertriglyceridemia, hypertension, diabetes, Syndrome X, atherosclerotic disease, cardiovascular disease, cerebrovascular disease, peripheral vessel disease, cholesterol gallstones, cancer, menstrual abnormalities, infertility, polycystic ovaries, osteoarthritis, and sleep apnea. In another embodiment, the present invention provides a method of treatment of a disorder comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I), wherein the disorder is selected from the group consisting of female sexual disfunction, male sexual disfunction, and erectile disfunction The compounds of Formula (I) may be used in combination with one or more therapeutic agents which are used in the treatment, prevention, amelioration, and/or supression of diseases for which the compounds of Formula (I) are useful; such other therapeutic agents may be administered by a like route or different route that the compound of Formula I. Where a compound of Formula (I) is utililized in combination with another therapeutic agent, the composition may contain the compound of Formula (I) in combination with the other therapeutic agent(s). Where separate dosage formulations are used, the compound of Formulae (I) and one or more additional therapeutic agents may be administered at essentially the same time (e.g., concurrently) or at separately staggered times (e.g., sequentially). In another embodiment, the present invention provides a method of treatment of an obesity-related disorder comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I) in combination with one or more hypoglycemic agents. In another embodiment, the present invention provides a method of treatment of an obesity-related disorder comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I) in combination with one or more agents that modulate digestion and/or metabolism. The agents that modulate digestion and/or metabolism may include, but are not limited to, agents that modulate thermogenesis, lipolysis, gut motility, fat absorption, and satiety. In another embodiment, the present invention provides a method of treating obesity and obesity-related disorders comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I) in combination with one or more agents selected from the group consisting of HMG CoA reductase inhibitor, bile acid binding agent, fibric acid derivative, and agent that regulates hypertension. In another embodiment, the present invention provides a method of treatment comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I) in combination with one or more agents such as, but not limited to, antiobesity agents such as fenfluramine, dexfenfluramine, sibutramine, orlistat, or β3 adrenoceptor agonists; feeding behavior modifying agents such as neuropeptide Y receptor antagonists, including those that antagonize the neuropeptide Y5 receptor; α-MSH, α -MSH mimetics, or α-MSH derived peptides; MC-4R agonists or partial agonists such as, but not limited to, those disclosed in US Patent No. 6,350,760; MC-3R agonists; glucokinase activators; PPAR-δ agonists; PPAR-α /PPAR-γ agonists; PPAR-α /PPAR-γ /PPAR-δ agonists; PPAR- Y /PPAR-δ agonists; and agents useful in treatment of male and/or female sexual disfunction, such as type V phosphodiesterase inhibitors such as sildenafil or tendamifil, dopamine agonists, or α2-adrenoceptor antagonists. In another embodiment, the present invention provides a method of treatment comprising: administering to a subject a therapeutically effective amount of at least one compound of Formula (I), wherein said therapeutically effective amount is sufficient to induce weight loss in the subject. In another embodiment, the present invention provides a method of prevention of weight gain comprising: administering to a subject a therapeutcially effective amount of a compound of Formula (I) which is sufficient to prevent weight gain. In another embodiment, the present invention provides a method of melanocortin receptor modulation comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I). In another embodiment, the present invention provides a method of melanocortin receptor modulation comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I), wherein said therapeutically effective amount is an amount that enhances the downstream effects of agonist binding to the melanocortin receptor in the subject. In another embodiment, the present invention provides a method of melanocortin receptor modulation comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I), wherein the compound of Formula (I) inhibits the function of AgRP on MC-4R. In another embodiment, the present invention provides a method of melanocortin receptor modulation comprising: administering to a subject a therapeutically effective amount of a compound of Formula (I), wherein the compound of Formula (I) inhibits the function of AgRP on MC-3R. Generally speaking, a compound of Formula (I) may be administered at a dosage level of from about 0.003 to 500 mg/kg of the body weight of the subject being treated. In an embodiment, a compound of Formula (I) may be administered at a dosage range between about 0.003 and 200 mg/kg of body weight per day. In an embodiment, a compound of Formula (I) may be administered at a dosage range between about 0.1 to 100mg/kg of body weight per day. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage may vary depending upon the host treated and the particular mode of administration. For example, a formulation intended for oral administration to humans may contain 1 mg to 2 grams of a compound of Formula (I) with an appropriate and convenient amount of carrier material which may vary from about 5 to 95 percent of the total composition. Dosage unit forms may generally contain between from about 5 mg to about 500mg of active ingredient. This dosage may be individualized by the clinician based on the specific clinical condition of the subject being treated. Thus, it will be understood that the specific dosage level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing therapy. Examples The general procedures used in the methods to prepare the compounds of the present invention are described below. General Experimental LC-MS data was obtained using gradient elution on a parallel MUX™ system, running four Waters 1525 binary HPLC pumps, equipped with a Mux-UV 2488 multichannel UV-Vis detector (recording at 215 and 254 nM) and a Leap Technologies HTS PAL Auto sampler using a Sepax GP-C184.6x50 mm column. A three minute gradient was run from 25% B (97.5%acetonitrile, 2.5% water, 0.05% TFA) and 75% A (97.5% water, 2.5% acetonitrile, 0.05% TFA) to 100% B. The system is interfaced with a Waters Micromass ZQ mass spectrometer using electrospray ionization. All MS data was obtained in the positive mode unless otherwise noted. 1 H NMR data was obtained on a Varian 400 MHz spectrometer.

Abbreviations used in the Examples are as follows: APCI = atmospheric pressure chemical ionization BOC = tert-butoxycarbonyl BOP= (1 -benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate CDI = 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide d = day DlAD = diisopropyl azodicarboxylate DBU = 1 ,8-diazabicyclo[5.4.0]undecene-7 DCC = dicyclohexylcarbodiimide DCE = dichloroethane DCM = dichloromethane DIC = diisopropylcarbodiimide DIEA = diisopropylethylamine DMA = N, N-dimethylacetamide DMAP = dimethylaminopyridine DME = 1 ,2 dimethoxyethane DMF = N, N-dimethylformamide DMPU = 1 ,3-dimethypropylene urea DMSO = dimethylsulfoxide Et = ethyl iPr = isopropyl Ph = phenyl Bn = benzyl Me = methyl tBu = tert-butyl Pr = propyl Bu = butyl iBu = isobutyl EDC =1 -ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride EDTA = ethylenediamine tetraacetic acid ELISA = enzyme - linked immunosorbent assay ESI = electrospray ionization ether = diethyl ether EtOAc = ethyl acetate FBS = fetal bovine serum g = gram h = hour HBTU = O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate HMPA= hexamethylphosphoric triamide HOBt =1 -hydroxybenzotriazole Hz = hertz i.v. = intravenous kD = kiloDalton L = liter LAH = lithium aluminum hydride LDA = lithium diisopropylamide LPS = lipopolysaccharide M = molar m/z = mass to charge ratio mbar = millibar MeOH = methanol mg = milligram min = minute mL = milliliter mM = millimolar mmol = millimole mol = mole mp = melting point MS = mass spectrometry N = normal NBS = N-bromosuccinimide NCS = N-chlorosuccinimide NMM = N-methylmorpholine, 4-methylmorpholine NMP = N-methyl pyrrolidone NMR = nuclear magnetic resonance spectroscopy p.o. = per oral PS-carbodiimide = N-cyclohexylcarbodiimide-N'-propyloxymethyl polystyrene PBS = phosphate buffered saline solution PMA = phorbol myristate acetate ppm = parts per million psi = pounds per square inch Rf = relative TLC mobility rt = room temperature s.c. = subcutaneous SPA = scintillation proximity assay TEA = triethylamine TFA = trifluoroacetic acid TFFH = f|uoro-N,N,N",N"-tetramethylformamidinium hexafluorophosphate THF = tetrahydrofuran THP = tetrahydropyranyl TLC = thin layer chromatography TMSBr= bromotrimethylsilane, trimethylsilylbromide Tn = retention time

General Procedure A To a methanol solution of ketone (such as 1-phenyl-ethanone, 1-phenyl-propanone, 1,2-diphenyl ethan'one, or 1-(4-isopropyl phenyl) ethanone) (1.0 eq) was added pyrrolidone hydrotribromide (PyHBr3) (1.1 eq) at O0C. The reaction was slowly warmed to room temperature and stirred at the same temperature for 2 h by monitoring with TLC. The reaction mass was concentrated and partitioned between cold aqueous sodium bicarbonate and ethyl acetate (1 :1 ). The organic phase was dried with Na2SO4, concentrated and filtered through a bed of silica gel to afford the alpha-bromo ketone. General Procedure B To an alpha-bromo ketone (Commercial or made from above procedure A, 1.0 eq) in methanol was added thiourea or 1 ,1-dialkylthiourea (1.1 eq) and the reaction was heated at 6O0C for 30 min. The reaction mass was concentrated and partitioned between aqueous sodium bicarbonate and ethyl acetate (1:1). Aqueous layer was washed with ethyl acetate (3 x 15 mL); combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The crude residue was purified by silica gel chromatography to afford the 2- aminothiazole derivative. Other variations of the above reaction conditions consist of performing the reaction in THF (at 6O0C, 1 h) or in NMP (at room temperature, 2-15 h). General procedure C Method C1 : A thiazol-2-ylamine (1.0 eq) and sulfonyl chloride (1.1 eq) were dissolved in THF, and NaH (1.5 eq, 60% suspension in mineral oil) was added at O0C. After the NaH addition, the reaction was warmed to room temperature and stirred at the same temperature for 4 h. The reaction was quenched with the addition of brine. The reaction mixture was extracted into ethyl acetate (3 x 15 mL), combined organic layers were dried over Na2SO4 and concentrated. The crude residue was purified by silica gel chromatography to obtain the desired sulfonamide. Method C2: A thiazol-2-yl amine (1.0 eq), suifonyl chloride (1.3 eq), and pyridine (3.0 eq) were combined in DCM. After stirring at room temperature for 16 h, the reaction mixture was loaded directly on silica gel column. Purification by flash chromatography (ethyl acetate/hexanes) gave the sulfonamide compound. Method C3: A thiazol-2-yl amine (1.0 eq), sulfonyl chloride (1.2 eq), triethylamine (2.0 eq), and DMAP (0.1 eq) were combined in DCM. After stirring at 0 0C for 4 h, saturated NaHCO3 (aq) solution was added. The mixture was extracted with ethyl acetate (1 x 10 mL). The ethyl acetate layer was dried over Na2SO4. Purification by flash chromatography (silica gel, ethyl acetate/hexanes) gave the sulfonamide. Method C4: A thiazol-2-yl amine (1.0 eq), sulfonyl chloride (1.2 eq), triethylamine (2.0 eq), and DMAP (0.1 eq) were combined in DCM. Resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 1000C for 30 min. After cooling to room temperature, saturated NaHCO3 (aq) solution was added. The mixture was extracted with DCM (2 x 4 mL). The combined organic layer was dried over Na2SO4 and concentrated. Purification was carried out by silica gel chromatography (silica gel, ethyl acetate/hexanes) to yield the desired sulfonamide. 5 013386

General procedure D A mixture of aldehyde/ketone (1.0 eq) and amine (1.0 eq) in DCM was stirred for 5 min. Sodium triacetoxyborohydride (1.2 eq) was added in portions and stirred until completion of the reaction. The reaction mixture was partitioned between DCM and saturated aqueous NaHCO3 solution. The aqueous layer was extracted again with DCM (1 x 15 ml_). The combined organic extracts were dried over K2CO3. After evaporating the solvents, the crude product was dissolved in THF (20 ml_) and Fmoc-isothiocyanate (0.9 eq) was added. The reaction was stirred at room temperature for 0.5 - 15 h. After TLC indicated the completion of the reaction, diethyl amine was added and stirred for 1-2 h at room temperature. The solvents were evaporated, and the crude residue was filtered on a bed of silica gel to afford the desired 1,1-alkylated thiourea. General procedure E A 1 M BBr3 solution (3.0 eq) was added to a solution of the methoxybenzene or benzyloxycarbonyl compound (1.0 eq) in DCM at -4O0C. The reaction mixture was stirred at temperature for 5 min. and was allowed to slowly warm up to room temperature. The reaction was quenched with small amount of MeOH. The product was purified by chromatography (silica gel). General procedure F A mixture of sulfonamide or aminoheterocycle (1.0 eq), bromide (2.0 eq), potassium carbonate (3.0 eq) and DMF (or in some cases THF) was heated in an oil bath at 6O0C until the reaction was complete as indicated by TLC or LCMS. The reaction mixture was partitioned between ethyl acetate and saturated NaHCO3 (aq) solution. The organic layer was dried over Na2SO4. The product was purified by chromatography (silica gel). General procedure G Method G1 : A 4 N HCI solution in dioxane was added to a solution of Boc-protected amine and/or tert-butyl ester. It was shaken or stirred until TLC or LCMS indicated that the reaction was complete. The volatiles were evaporated. The remaining solid was purified by trituration in hexanes or ether. Method G2: To a solution of compound in dichloromethane was added 4 N HCI in dioxane (ca. 5 equiv). The reaction mixture was stirred 1 h at ambient temperature. The mixture was evaporated to dryness. A small amount of dichloromethane was added and the mixture was concentrated in vacuo; this process was repeated twice. The remaining solid was purified by trituration with hexanes or ether. The solid was collected and dried in vacuo to afford the HCI salt. General procedure H A mixture of nitrile (1.0 eq), sodium azide (13.2 eq), ammonium chloride (13.2 eq) and DMF was heated in an oil bath at 12O0C for 1 h. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4. The product was purified by chromatography (silica gel). General procedure 1 A mixture of nitrile (1.0 eq), 1 N NaOH (aq) solution and ethanol was refluxed until the reaction was complete as indicated by TLC or LCMS. The reaction mixture was concentrated and partitioned between ether and water. The aqueous layer was acidified with 10% HCI (aq) solution and extracted with ether (1 x 30 mL). The organic layer was dried over Na2SO4. The solvents were evaporated. The remaining solid was purified by trituration in hexanes. General procedure J A 1 N NaOH (aq) solution (1.0 eq) was added to a solution of carboxylic acid (1.0 eq) in THF (1 mL) and MeOH (1 mL). The volatiles were evaporated and the residue dried under high vacuum. The remaining solid was purified by trituration in hexanes or ether. General Procedure K A thiazole carboxylic acid (1.0 eq) was stirred at RT with CDl (3.0 eq) in anhydrous THF. After 20 hours, a prepared solution of the corresponding sulfonamide (2.0 eq), and DBU (1.5 eq) in THF was added, and the mixture was stirred at RT. The formation of the product was monitored via LCMS. After the reaction completed, the volatiles were removed, and residue was partitioned between EtOAc and 10 % citric acid. The organic layer was washed with citric acid, brine. The solution was dried over MgSO4, filtered and concentrated. The crude product was purified by silica gel column chromatography. General Procedure L The alcohol (1.5 eq) was dissolved in DMF (0.5 M) and NaH (1.1 eq, 60% suspension in mineral oil) was added in portions. The resulting slurry was sonicated for 20- 40 min. until ail the NaH was consumed. The resulting purple solution was charged with 4'- fluoroacetophenone (1.0 eq) and the reaction was stirred at 6O0C for 2-3 h. The reaction was quenched by the addition of water and saturated citric acid. The aqueous layer was extracted with methyl tert-butyl ether (MTBE, 3x20mL) and the combined organic layer was washed with water (4x15 mL) and brine. The organic layer was dried over MgSO4, filtered, and concentrated. The crude residue was purified on a silica gel column (gradient, hexane - > 4% EtOAc-hexane) to obtain the desired ether derivative. In some cases NMP was used. In addition, sonication may not be necessary when primary alcohols are utilized. In these cases the deprotonation can be done at room temperature for 10-20 min. General procedure M The aminothiazole (1.0 eq.) was dissolved in MeCN (4 mL, 0.1 M) and N- chlorosuccinimide (NCS) (1.05 eq.) was added. The reaction was heated to 7O0C for 2 h until complete by TLC analysis. The reaction mixture was then cooled to room temperature. Saturated NaHCO3 and brine were added. The aqueous layer was extracted with EtOAc (3x15 ml_) and dried over MgSO4. The residue was then filtered through silica gel (5% EtOAc-hexane). General Procedure N The ester (1.0 eq) was dissolved in THF (3 ml_) and cooled to -780C. The aryl Grignard reagent (3.0 eq) was added dropwise and slowly warmed to O0C over 2-3 h. The reaction was quenched by the addition of saturated ammonium chloride and extracted with EtOAc (3x15 mL). The combined organic layer was dried over MgSO4, filtered and concentrated. The residue was purified by silica gel chromatography (gradient, hexane -> 3% EtOAc-hexane). General procedure O TFA (2 mL) was added to the alcohol (1.0 eq.). Upon cooling to O0C, Et3SiH (2.0 eq) was added and the mixture was warmed to room temperature and stirred for 2 h. The volatiles were removed and aqueous NaOH (1.0 eq) was added. The mixture was extracted with CH2CI2 (3x15 mL) and the combined organic layer was dried over MgSO4, filtered and concentrated. Purification of the residue was accomplished by silica gel chromatography (gradient, hexane -> 1/1 EtOAc-hexane). General Procedure P Method P1 : To a THF solution of 2,4-dichloropyrimidine was (1.0 eq) added benzylamine (1.1 eq) at O0C. The cooling bath was removed and the reaction was stirred for 3 h at room temperature before adding aq. sodium carbonate solution. The aqueous layer was then extracted into ethyl acetate (3 x 20 mL), and the combined ethyl acetate extracts were dried over sodium sulfate and concentrated. The crude solid was purified by silica gel chromatography to obtain two different regioisomers in -3:1 ratio. Method P2: To a DMF or THF solution of 2,4-dichloro-pyrimidine (1 eq) was added the amine (1.5 eq) and DIEA (3.0 eq). The reaction was stirred at room temperature until complete (by TLC or LCMS). A saturated NaHCO3 (aq) solution was added to the reaction. The aqueous layer was extracted with ethyl acetate (3 x 5 mL), and combined ethyl acetate extracts were dried over sodium sulfate and concentrated. The crude solid was purified by silica gel chromatography. General Procedure Q Method Q1 : The boronic acid (1.5 eq), the chloropyrimidine (1.0 eq) and tetrakis(triphenylphosphino)palladium (5 mol% relative to the boronic acid) were added sequentially to degassed dimethoxyethylene (2 mL) and to this mixture degassed sodium carbonate solution was added (2.0 eq). Resulting reaction mixture was stirred under nitrogen for 12 h at 8O0C. After cooling to room temperature, ethyl acetate (15 mL) was added. It washed with brine, dried over sodium sulfate and concentrated. The crude product was purified on a silica gel column to provide the cross-coupling compound. Method Q2: The boronic acid (1.5 eq), the chloropyrimidine (1.0 eq) and tetrakis(triphenylphosphino)palladium (5 mol% relative to the boronic acid) were added sequentially to degassed dimethoxyethylene (2 ml_) and to this mixture degassed sodium carbonate solution was added (2.0 eq). Resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 15O0C for 30 min. After cooling to room temperature, ethyl acetate (5 mL) was added. The reaction mixture washed with brine, dried over sodium sulfate and concentrated. The crude product was purified by silica gel chromatography to yield the coupling compound. General Procedure R To the 2,4-dimethoxybenzyl derivative (1.0 eq) was added 20% TFA in DCM (10 mL) and stirred at room temperature for 1 h. The reaction mass was concentrated, and the residue was partitioned between DCM and sodium bicarbonate solution. The turbid DCM layer was concentrated and loaded onto silica gel column and eluted with 20% ethyl acetate in DCM to provide the amino compound. General Procedure S Method S1: To the N-alkyl or N-sulfonyl aminopyrimidine (1.1 eq) and alkyl bromide (1.0 eq) added NaH (60 % suspension, 1.5 eq) at O0C. The cooling bath was removed, and the reaction stirred at room temperature until complete. After quenching the reaction by adding small amount of methanol, brine (10 mL) and ethyl acetate (10 mL) were added. The brine layer was extracted with ethyl acetate (2 x 10 mL), and the combined ethyl acetate extracts were dried over sodium sulfate and concentrated. The obtained residue was purified on silica gel column to provide the alkylated compound. Method S2: To the N-alkylamino compound (1.0 eq) and alkyl bromide (1.5 eq) was added NaH (60 % suspension, 2.0 eq) at room temperature. The reaction was stirred at room temperature until complete. After quenching the reaction by adding small amount of methanol, brine (10 mL) and ethyl acetate (10 mL) were added. The brine layer was extracted with ethyl acetate (2 x 10 mL), and the combined ethyl acetate extracts were dried over sodium sulfate and concentrated. The obtained residue was purified on silica gel column to provide the alkylated compound. General Procedure T To a THF solution of the ester (1.0 eq) was added either LiOH or NaOH (5.0 eq) dissolved in H2O-MeOH (1 :1). The reaction was stirred at room temperature until complete. The solvent was evaporated, and the residue was partitioned between DCM and water. The pH of the aqueous layer was adjusted to ~pH 7 with 10% HCI (aq) solution and then extracted with DCM (3 x 2 mL). The combined organic layers were dried over Na2SO4 and concentrated. Example 1 2-Bromo-1-(4-isopropyl-phenyl)-ethanone was prepared (0.95 g) following general procedure A using 1-(4-isopropyl-phenyl)-ethanone (0.66 mL, 3.92 mmol) and pyrrolidone hydrotribromide (2.1 g, 4.31 mmol). 4-(4-lsopropyl-phenyl)-thiazol-2-ylamine was prepared (0.41 g) following general procedure B using 2-bromo-1-(4-isopropyl-phenyl)-ethanone (0.5 g, 2.07 mmol), thiourea (173 mg, 2.28 mmol) and MeOH (10 mL). LCMS m/z: 219 (M+1)+. N-[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-2,5-dimethoxy-benzen esulfonamide was prepared (62 mg) following general procedure C (method 1 ) using 4-(4-isopropyl-phenyl)- thiazol-2-yl amine (50 mg, 0.23 mmol), 2,5-dimethoxybenzenesulfonyl chloride (59 mg, 0.25 mmol), NaH (14 mg, 60%, 0.34 mmol) and THF (1 mL). LCMS m/z: 419 (M+1)+; 1H NMR (CDCI3, 400 MHz): δ 1.27 (d, 6H); 2.95 (m, 1H), 3.75 (s, 3H), 3.81 (3, 3H), 6.52 (s, 1H), 6.9 (d, 1 H), 7.0 (dd, 1H), 7.31 (m, 2H)1 7.44 (m, 2H), 7^6 (d, 1H), 10.2 (brs, 1H). Example 2 To a solution of t-butanol (0.3 mL) in THF (3 mL) was added 2-chlorosulfonylacetyl chloride (0.1 mL, 1.0 mmol) at room temperature for 1h. The volatiles were removed to provide the chlorosulfonyl-acetic acid tert-butyl ester (230 mg). .The crude product was used without further purification. 4-(4-lsopropyl-phenyl)-thiazol-2-ylamine, chlorosulfonyl-acetic acid tert-butyl ester, DMAP (10 mol%) were combined using general procedure C (method 2) to afford [4-(4- lsopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester. LCMS m/z: 398 (M+1 )+; 1H NMR (CDCI3, 400 MHz): 51.27 (d, 6H); 1.44 (s, 9H); 2.95 (m, 1H); 4.06 (s, 2H); 6.48 (s, 1H); 7.32 (d, 2H); 7.39 (d, 2H); 10.5 (brs, 1H). Example 3 [4-(4-lsopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester was combined with 4M HCI in dioxane as in general procedure G1 to furnish [4-(4-lsopropyl- phenyl)-thiazol-2-ylsulfamoyl]-acetic acid. LCMS m/z: 342 (M+1)+; 1H NMR (DMSO-d6, 400MHz): δ 1.22 (d, 6H); 2.92 (m, 1H); 4.04 (s, 2H); 7.17 (s, 1H); 7.33 (d, 2H); 7.66 (d, 2H); 12.98 (S); 13.2 (s). Example 4 Thiophen-2-yl-methyl-thiourea was prepared (146 mg) following general procedure D, using 2-aminomethyl-thiophene ( 0.1 mL, 0.97 mmol)), Fmoc-isothiocyante ( 300 mg, 1.1 mmol) add diethylamine (0.5 mL). LC-MS m/z: 173 (M+1)+. [4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyi-am ine was prepared (85 mg) following general procedure B using 2-bromo-1-(4-isopropyl-phenyl)-ethanone ( 72 mg, 0.3 mmol), thiophen-2-yl-methyl-thiourea(57 mg, 0.33 mmol). LC-MS (m/z): 315 (M+1)+. [4-(4-lsoprepyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-am ine, chlorosulfonyl-acetic acid tert-butyl ester were combined according to general procedure C (method 2) to provide {[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-s ulfamoyl}-acetic acid tert-butyl ester. LCMS m/z: 494 (M+1)+. The above ester was treated with 4M HCI as outlined in general procedure G1 to provide {[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-s ulfamoyl}-acetic acid. LCMS m/z: 438 (M+1)+. By analogous methods to those used to prepare Examples 1-3 and those in the relevant above Schemes, the following compounds were synthesized. In addition to methods used to prepare Examples 1-3, the compound of Example 13 was prepared from Example 12 following general procedure E to demethylate the methyl ether.

Example 25 {(2,5-Dimethoxy-benzenesulfonyl)-[4-(4-isopropyl-phenyl)-thi azol-2-yl]-amino}-acetic acid tert-butyl ester was prepared following general procedure F using N-[4-(4-isopropyl- phenyl)-thiazol-2-yl]-2,5-dimethoxy-benzenesulfonamide (126 mg', 0.3 mmol), tert-butyl bromoacetate (90.4 μL, 98%, 0.6 mmol), potassium carbonate (124 mg, 0.9 mmol) and DMF (1 ml_). Purification (silica gel, ethyl acetate/hexanes 1:4) gave the product compound (111 mg, 0.208 mmol). LCMS m/z: 533 (M+1)+. {(2,5-Dimethoxy-benzenesulfonyl)-[4-(4-isopropyl-phenyl)-thi azol-2-yl]-amino}-acetic acid was prepared following general procedure G1 using a solution of {(2,5-dimethoxy- benzenesulfonyl)-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino }-ace|ic acid tert-butyl ester (96.8 mg, 0.182 mmol) in DCM (3 mL) and 4 N HCI solution in dioxane (2.5 ml_) followed by trituration in hexanes to give {(2,5-Dimethoxy-benzenesulfonyl)-[4-(4-isopropyl-phenyl)- thiazol-2-yl]-amino}-acetic acid. 1H-NMR (400 MHz, CDCI3): 7.64(d, 2H), 7.55(d, 1H), 7.09- 7.26(m, 3H), 6.87(d, 1H), 4.85(s, 2H), 3.82(s, 3H), 3.66(s, 3H), 2.92(sept, 1H), 1.25(d, 6H); LCMS m/z: All (M+1)+. By analogous methods to those used to prepare Example 25 and those in the relevant above Schemes, the following compounds were synthesized.

Example 35 3-[(Thiophen-2-ylmethyl)-amino]-propionitrile was prepared following general procedure D using thiophene-2-carboxaldehyde (477 μl_, 98%, 5 mnnol), 3-amino- propionitrile (373 μL, 99%, 5 mmol), 1 M acetic acid solution in DCE (6 mL), DCE (9 ml_) and sodium triacetoxyborohydride (1.31 g, 97%, 6 mmol). The crude product was used without further purification. LCMS m/z: 167 (M+1)+. 3-[(thiophen-2-ylmethyl)-amino]-propionitrile (from previous step) and Fmoc isothiocyanate (1.48 g, 5 mmol) were dissolved in THF (8 mL). The mixture was stirred for 35 min. and diethyl amine (2 mL) was added. The reaction was stirred for a further 2 h. The resulting thiourea, after treating with hexanes, was used without further purification. LCMS m/z: 226 (M+1)+. ' 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}-propionitrile was prepared following general procedure B using 2-bromo-1-(4-isopropyl-phenyl)-ethanone (5 mmol), 1-(2-cyano-ethyl)-1-thiophen-2-ylmethyl-thiourea (from previous step) and MeOH (15 mL). Purification by flash chromatography (ethyl acetate/hexanes 1 :7, 1 :4) gave the propionitrile (1.013 g, 2.76 mmol). LCMS m/z: 368 (M+1 )+. 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}-propionic acid was prepared following general procedure I using 3-{[4-(4-isopropyl-phenyl)-thiazol~2-yl]- thiophen-2-ylmethyl-amino}-propionitrile (368 mg, 1 mmol), 1 N NaOH (aq) solution (4 mL) and ethanol (2 mL). The mixture was refluxed for 15 h. Trituration in hexanes gave 3-{[4-(4- isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-p ropionic acid. LCMS m/z: 387 (M+1)+. The sodium salt was prepared following general procedure J using 3-{[4-(4- isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-p ropionic acid (93.8 mg, 0.243 mmol), 1 N NaOH (aq) solution (0.243 mL), THF (1 mL) and MeOH (1 mL). Trituration in hexanes gave sodium 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}- propionate. 1H-NMR (400 MHz, CD3OD): 7.78-7.81 (m, 2H), 7.22-7.28(m, 3H), 7.13-7.14(m, 1H), 6.94- 6.96(m, 1H), 6.83(s, 1H), 4.99(s, 2H), 3.70(dd, 2H), 2.91 (sept, 1H), 2.56-2.59(m, 2H), 1.26(d, 6H); LCMS m/z: 387 (M+1 )+. Example 36 3-(1-Thiophen-2-ylmethyl-thioureido)-propionic acid tert-butyl ester was prepared (750 mg) following general procedure D using thiophene-2-carbaldehyde (0.466 ml_, 5 mmol), beta-alanine tert-butyl ester hydrochloride (905 mg, 5 mmol), sodium triacetoxyborohydride (1.27 g, 6 mmol), Fmoc isothiocyanate (1 A g, 95.3%, 5 mmol), and diethyl amine (2 ml_). LCMS m/z: 301 (M+1)+. 3-{Thiophe'n-2-ylmethyl-[4-(4-p-tolyl)-thiazol-2-yl]-amino}- propionic acid tert-butyl ester was prepared (37 mg, 89%) following general procedure B using 2-bromo-1-(4-tolyl)- ethanone (21 mg, 0.1 mmol), 3-(1~thiophen-2-ylmethyl-thioureido)-propionic acid tert-butyl ester (30 mg, 0.1 mmol). LCMS m/z: 416 (M+1)+. 3-{Thiophen-2-ylmethyl-[4-(4-p-tolyl)-thiazol-2-yl]-amino}pr opionic acid hydrochloride was prepared (35 mg) following general procedure G1 using 3-{thiophen-2-ylmethyl-[4-(4- tolyl)-thiazol-2-yl]-amino}propionic acid tert-butyl ester (37 mg, 0.089 mmol) and 4 N HCI solution in dioxane (1.0 mL). LCMS m/z: 360 (M+1)+. 1H NMR (CDCI3, 400 MHz): δ 2.4 (s, 3H), 3.1 (t, 2H), 4.3 (t, 2H), 5.2 (s, 2H), 6-5-7.8 (Ar-H, 8H). Example 37 Trans-4-methyl-cyclohexanol (4.0 g, 35.03 mmol), 4'-fluoroacetophenone (166.1 mg, 1.202 mmol), DMF (60 mL) and NaH (1.33 g, 33.3 mmol, 60% suspension in mineral oil) were combined as outlined in general procedure L using sonication. After aqueous workup the residue was purified by silica gel chromatography (gradient, hexane ,-> 4% EtOAc- hexane) to obtain the desired ether (2.86 g). The above acetophenone derivative (2.30 g, 9.91 mmol), pyrrolidone hydrotribromide (5.2 g, 10.48 mmol) and MeOH (70 mL) were combined according to general procedure A. After aqueous workup, the resulting 2-bromoketone was used without further purification. The 2-bromo-1-[4-(trans-4-methyl-cyclohexyloxy)-phenyl]-ethanone (764 mg, 3.44 mmol), 3-(1-cyclopentyl-thioureido)-propionic acid tert-butyl ester (935 mg, 2.46 mmol), NMP (6 mL) were combined as indicated in general procedure B. The reaction was stirred at room temperature overnight. After an aqueous work up, the crude product was purified by silica gel chromatography (gradient, hexane -> 3% EtOAc-hexane) to afford 3-(cyclopentyl- {4-[4-(trans-4-methyl-cyclohexyloxy)-phenyl]-thiazol-2-yl}-a mino)-propionic acid tert-butyl ester (1.05 g). 86

The above ester (94.6 mg, 0.195 mmol) and 4M HCI in dioxane (3 mL) were combined utilizing general procedure G1 to afford the HCI salt of 3-(cyclopentyl-{4-[4-(trans 4-methyl-cyclohexyloxy)-phenyl]-thiazol-2-yl}-amino)-propion ic acid (77.5 mg), LCMS m/z: 430 (M+1)+. Example 38 3-(1-Cyclopentyl-thioureido)-propionic acid tert-butyl ester was preparaed using general procedure D with cyclopentanone, beta-alanine tert-butyl ester hydrochloride, sodium triacetoxyborohydride, Fmoc isothiocyanate, and diethyl amine. 3-{[5-Chloro-4-(2,4-dimethyl-phenyl)-thiazol-2-yl]-cyclopent yl-amino}-propionic acid tert-butyl ester was prepared from 2-bromo-1-(2,4-dimethyl-phenyl)-ethanone (216 mg, 0.952 mmol), 3-(1-cyclopentyl-thioureido)-propionic acid tert-butyl ester (520 mg, 1.911 mmol), and MeOH (6 mL) following general procedure B. After aqueous workup, the residue was purified by silica gel chromatography (gradient, hexane->5% EtOAc-hexane) to afford the thiazole ester (330 mg). The above ester (135.4 mg, 0.339 mmol), NCS (46.7 mg, 0.349 mmol) and MeCN (4 mL) were combined according to general procedure M. After aqueous workup, the chlorothiazole was purified by silica gel chromatography (gradient, hexane->5% EtOAc- hexane) to furnish 3-{[5-chloro-4-(2,4-dimethyl-phenyl)-thiazol-2-yl]-cyclopent yl-amino}- propionic acid tert-butyl ester (134.4 mg). The above ester (134 mg, 0.308 mmol) and 4M HCI in dioxane (2 mL) were combined utilizing general procedure G1 to afford the HCI salt of 3-{[5-chloro-4-(2,4- dimethyl-phenyl)-thiazol-2-yl]-cyclopentyl-amino}-propionic acid (113.5 mg, 89%), LCMS m/z: 380 (M+1)+. Example 39 3-[4-(4-lsopropyl-phenyl)-thiazol-2-ylamino]-propionic acid tert-butyl ester was prepared from 3-amino-propionic acid tert-butyl ester (570 mg, 3.13 mmol), Fmoc-NCS (968 mg), via general procedure D to yield the Fmoc protected 3-thioureido-propionic acid tert- butyl ester (1.3 g). The Fmoc group was removed with Et2NH (2 mL). Combination of the above thiourea, 2-Bromo-1-(4-isopropyl-phenyl)-ethanone by means of general procedure B furnished 3-[4-(4-lsopropyl-phenyl)-thiazol-2-ylamino]- propionic acid tert-butyl ester (850 mg). LCMS m/z: 348 (M+1 )+. 3-{[4-(4-lsdpropyl-phenyl)-thiazol-2-yl]-thiophen-3-yl-amino }-propionic acid tert-butyl ester was synthesized by combining the above prepared 2-aminothiazole ester (200 mg, 0.577 mmol), Cu(OAc)2 (208mg, 1.154 mmol), thiophene-3-boronic acid (110 mg, 0.866 mmol), and powdered 4 A molecular sieves (200 mg). The reaction mixture was diluted with dichloromethane (5 mL) and triethylamine (0.42 mL, 2.886 mmol). After stirring the heterogenous reaction mixture for 24h at room temperature under ambient atmosphere; the resulting slurry was filtered and the product was isolated from the organic filtrate by flash chromatography (eluant: 20% ethyl acetate in hexanes). Yield 16 mg. LCMS m/z: 430 (M+1)+. 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-3-yl-amino }-propionic acid was prepared from the above ester using general procedure Gl 1H NMR (DMSO-d6, 400 MHz): δ 1.22 (d, 6H); 2.70 (m, 2H), 2.90 (m, 1H); 3.81 (bra, 1H); 4.16 (m, 2H), 7.15 (s, 1H), 7.29 (m, 3H); 7.67 (m, 2H); 7.77 (m, 2H). By analogous methods to those used to prepare Examples 35-39 and those in the relevant above Schemes, the following compounds were synthesized. HCI salts were prepared using general procedure G1. Sodium salts were prepared using general procedure J. All other compounds in the table below were prepared as the neutral free carboxylic acid.

Example 100 To a solution of 1-phenyl-propane-1,2-dione (1,72 g, 0.0116 mol) in DCE (5 ml_) was added Br2 (1.87g, 0.0169 mol). The reaction mixture was stirred for 75 min. and the volatiles were removed to yield 3.21 g of 3-bromo-1-phenyl-propane-1 ,2-dione. The crude bromoketone (0.1046 mol) was combined at room temperature with 3-(1-cyclopentyl- thioureido)-propionic acid tert-butyl ester (7.00 g, 0.031 mol) in NMPi(50 ml_) following . general procedure B. The reaction was purified by silica gel chromatography (gradient,. hexane->8% EtOAc-hexane) to yield 3-[(4-Benzoyl-thiazol-2-yl)-cyclopentyl-amino]-propionic acid tert-butyl ester (4.0 g). The above tert-butyl ester (78.8 mg, 0.197 mmol) was combined with 4M HCI in dioxane (2 mL) following general procedure G1 to afford 3-[(4-benzoyl-thiazol-2-yl)- cyclopentyl-amino]-propionic acid (60.7 mg). The above ketoacid (40 mg, 0.105 mmol), 4-tert-butylphenylmagnesium bromide (0.384 mmol) and THF (3 mL) were combined as outlined in general procedure N. After aqueous workup the residue was purified by silica gel chromatography (gradient, CH2CI2 -> 2% MeOH-CH2CI2) to afford the desired 3-({4-[(4-tert-Butyl-phenyl)-hydroxy-phenyl-methyl]- thiazol-2-yl}-cyclopentyl-amino)-propionic acid (24 mg). The alcohol (24 mg, 0.0502 mmol), TFA (1.0 mL) and Et3SiH (0.10 mL) were combined according to general procedure O. After aqueous workup the residue was purified by silica gel chromatography (gradient, CH2CI2 -> 2% MeOH-CH2CI2). The sodium salt was prepared via general procedure J to afford sodium 3-({4-[(4-tert-butyl-phenyl)-phenyl- methyl]-thiazol-2-yl}-cyclopentyl-amino)-propionate (10.3 mg). LCMS m/r. 464 (M+1). Example 101 Ethyl bromopyruvate (0.13 mL, 0.932 mmol), 3-(1-Cyclopentyl-thioureido)-propionic acid tert-butyl ester (243 mg, 0.893 mmol) were combined in THF (3 mL) following general procedure B. The reaction was purified by silica gel chromatography (gradient, hexane- >10% EtOAc-hexane) to yield 2-[Cyclopentyl-(2-ethoxycarbonyl-ethyl)-amino]-thiazole-4- carboxylic acid tert-butyl ester (208 mg). 3-{Cyclopentyl-[4-(hydroxy-diphenyl-methyl)-thiazol-2-yl]-am ino}-propionic acid tert- butyl ester was prepared using general procedure N. The diester (185 mg, 0.503 mmol) in THF (3 ml) was combined with phenylmagnesium bromide (1.53 mmol) at -780C. After aqueous workup the residue was purified by silica gel chromatography (gradient, hexane -> 3% EtOAc-hexane) to afford the desired 3° alcohol (131 mg). The above alcohol (131 mg, 0.274 mmol), TFA (2.0 mL) and Et3SiH (0.23 mL) were combined according to general procedure O. After aqueous workup the residue was purified by silica gel chromatography (gradient, hexane -> 1/1 EtOAc-hexane). After concentration and trituration from hexane, 3-[(4-Benzhydryl-thiazol-2-yl)-cyclopentyl-amino]-propionic acid (45 mg, 40%) was obtained. LCMS m/z: 408 (M+1 ). The HCI salt was also prepared, using general procedure G2, by the addition of 4 M HCI in dioxane. By analogous methods to those used to prepare Example 100-101 and those in the relevant above Schemes, the following compounds were synthesized. HCI salts were prepared using general procedure G1. All other compounds in the table below were prepared as the neutral free carboxylic acid.

Example 106 2-bromomethyl-benzoic acid methyl ester (Dvornikovs, V.; Smithrud, D. B.; J. Org. Chem.; 2002, 67, 2160 - 2167) was prepared, via the cited literature preparation, from methyl 2-methylbenzoate by alpha-bromination (NBS, benzoyl peroxide, CCI4, 8O0C). Cyclopentyl-thiourea was prepared following procedure D using cyclopentyl amine (2.4 g, 28 mmol), and Fmoc-isothiocyanate (5.6 g, 20 mmol). Purification (Silica gel, ethyl acetate/hexaπe 1:1, 100%) provided the product (1.6 g) as white a solid. LCMS m/z: 145 (M+1)+. Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine was prepared following procedure B using cyclopentyl-thiourea (1.6g, 10.7 mmol) and 2-bromo-1-(4-isopropyl- phenyl)-ethanone (2.6g, 10.7 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the product (2.9 g). LCMS m/z: 287 (M+1)+. 2-({Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino} -methyl)-benzoic acid (19 mg) was prepared following general method S2 using cyclopentyl-[4-(4-isopropyl-phenyl)- thiazol-2-yl]-amine (80mg, 0.28 mmol), 2-bromomethyl-benzoic acid methyl ester (68 mg, 0.33 mmol) and NaH (34 mg, 60%, 0.84 mmoi). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following general procedure T. Sodium 2- ({cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}-m ethyl)-benzoate was prepared following procedure J. LCMS m/z: 422 (M+1)+. By analogous methods to those used to prepare Example 106 and those in the relevant above Schemes, the following compounds were synthesized. The starting 3- or 4- bromomethyl benzoic acid methyl esters used in Examples 108-110, 112, and 114-117 were obtained from commercial sources.

Example 118 4-[(1-Cyclopentyl-thioureido)-methyl]-benzoic acid methyl ester (550 mg) compound was prepared following general procedure D using cyclopentylamine (935mg, 11.0 mmol), 4- formylmethylbenzoate (1.64g, 10.0 mmol), and Fmoc-isothiocyanate (9mmol). Purification: (Silica gel, ethyl acetate/hexane 1:1). LCMS m/z: 293.0 (M+1 )+. cis-4-Methyl-cyclohexanol (3.28 g, 28.7 mmol), NaH (1.09 g, 27.3 mmol, 60% suspension in mineral oil) and DMF (50 ml_) were combined and sonicated as in general procedure L. The mixture was charged with 4'-fluoroacetophenone (2.18 ml_, 17.8 mmol) and heated. After aqueous workup, the crude residue was purified on a silica gel column (gradient, hexane -> 2% EtOAc-hexane) to obtain 1-[4-(cis-4-Methyl-cyclohexyloxy)-phenyl]- ethanone (976 mg). 2-Bromo-1-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-ethanonei( 650 mg) was prepared following procedure A using 1-[4-(4-Methyl-cyclohexyloxy)-phenyl]-ethanone (464 mg, 2.0 mmol) and pyrrolidone hydrotribromide (701 mg, 2.2 mmol). 4-[(Cyclopentyl-{4-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-t hiazol-2-yl}-amino)- methyl]-benzoic acid (90 mg) was prepared following procedure B using 4-[(1-cyclopentyl- thioureido)-methyl]-benzoic acid methyl ester (150 mg, 0.5 mmol) and 2-bromo-1-[4-(4- methyl-cyclohexyloxy)-phenyl]-ethanone (0.5 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following procedure T. Sodium 4-[(cyclopentyl-{4-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-t hiazol-2-yl}-amino)- methyl]-benzoate was made following procedure J. LCMS rn/z: 492 (M+1)+. By analogous methods to those used to prepare Example 118 and those in the relevant above Schemes, the following compounds were synthesized. The starting 2-bromomethyl benzoic acid methyl ester (Dvornikovs, V.; Smithrud, D. B.; J. Org. Chem.; 2002, 67, 2160 - 2167) used in Examples 122-124 was prepared via the cited literature preparation, from methyl 2-methylbenzoate by alpha-bromination (NBS, benzoyl peroxide, CCI4, 8O0C).

Example 128 3-Chlorocarbonyl-isonicotinic acid methyl ester was prepared by refluxing a mixture of pyridine-3,4-dicarboxylic acid 4-methyl ester (100 mg) and thionyl chloride (75 μl) in chloroform (5 ml) for 3h. After cooling to room temperature, volatiles were evaporated, and the residue was dried under high vacuum to give the product (100 mg). 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -carbamoyl}-isonicotinic acid (20 mg) was prepared by adding 3-chlorocarbonyl-isonicotic acid methyl ester added to (4-(-isopropyl-phenyl)-thiazol-2-yl)-thiophen-2-ylmethyl-ami ne (80 mg. 0.43 mmol), TEA (300 μl_), and DMAP (10 mg) in THF (3 ml_). After 7 h reaction was partitioned between EtOAc (30 ml_) and water (10 mL), the organic layer washed with brine (10ml), dried (MgSO4), filtered, and concentrated. The residual oil was purified by column chromatography eluting with (10-40-%) EtOAc in hexane to give the ester (30 mg), which was hydrolyzed according to general procedure T. : Sodium 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2- ylmethyl-carbamoyl}-isonicotinate was made following procedure J. LCMS m/z: 465 (M+1)+. Example 129 4,5-Dichloro-N-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-phthala mic acid (20 mg) was prepared by heating (4O0C) a mixture of (4-(-isopropyl-phenyl)-thiazol-2-yl)-thiophen-2- ylmethyl-amine (44 mg, 0.22 mmol), 4,5-dichloro-2,3-benzenedicarboxylic anhydride (44.0 mg, 0.2 mmol) in acetonitrile (3.0ml) for 2.0 h. The volatiles removed under high vacuum, and the residue was purified by column chromatography eluting with 5% methanol in DCM. LCMS m/z: 436 (M+1)+. By analogous methods to those used to prepare Examples 128 and 129 and those in the relevant above Schemes, the following compounds were synthesized.

Example 134 N-(3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmet hyl-amino}-propionyl)- benzenesulfonamide was prepared following procedure K using 3-{[4-(4-isopropyl-phenyl)- thiazol-2-yl]-thiophen-2-ylmethyl-amino}-propionic acid (Prepared in Example 35) (50 mg, 0.125 mmol), CDI (62mg, 0.39 mmol), DBU (30 μl, 0.2. mmol), and benzene sulfonamide (41 mg, 0.26 mmol). Purification (Silica gel, ethyl acetate/hexane 1 :4) provided the product (10 mg). LCMS m/z: 527 (M+1)+. By analogous methods to those used to prepare Example 134 and those in the relevant above Schemes, the following compounds were synthesized. Examples 143-144 in the table below were prepared as the HCI salt using general procedure G2. Example 144 was prepared as the dihydrochloride salt. Examples 135-142 were prepared as the neutral compound.

Example 145 t-Butylbromoacetate (1.45 ml_, 10 mmol) was added to 2-aminomethyl thiophene (1.13 g. 10.0 mmol) and DIEA (2.0 ml) in THF (20 mL). The mixture was warmed to room temperature (4h), diluted with ether (100 mL) and washed with water (20 mL), brine (20 mL), dried (MgSO4), filtered and evaporated in vacuum. The product was purified by column chromatography eluting with 10-25% EtOAc in hexane to give [(thiophen-2-ylmethyl)-amino]- acetic acid tert-butyi ester (1.2 g). LCMS m/z: 229 (M+ 1 )+. A mixture of ethylthiooxamate (2.1 g, 15.8 mmol) and 2-bromo-4'- isopropylacetophenone (3.8 g, 15.8 mmol) in ethanol (10 ml_) was heated at 60 0C for 15 h. After cooling to room temperature, ethanol was evaporated, and the residue was partitioned between saturated sodium bicarbonate solution and EtOAc, organic layer was washed with brine, dried (MgSO4), filtered, and concentrated in vacuum. The residue was purified by flash chromatography eluting with 5% EtOAc in hexane to give the ester (3.0 g). Lithium aluminum hydride (205 mg, 5.5 mmol) was added to a cooled (0°C) THF (15 mL) solution of the ester, after 3 h NaOH (1 .0 M, 1.0 ml) was added, and stirring continued for another 1.0 h to give a white precipitate, which was removed by filtration, the filtrate was diluted with Et2O (50 mL), dried (MgSO4) filtered, and concentrated in vacuum to give the corresponding alcohol. LCMS m/z: 235 (M+1)+. The crude alcohol was then taken in DCM (5 ml) and added to a suspension of PCC (1.8 g), and celite (3.6g) in DCM (20 mL), stirring continued for 3h. The reaction mixture was diluted with Et2O (100 mL) and filtered through a plug of silica gel, the filtrate was concentrated in vacuum to give 4-(4-lsopropyl-phenyl)-thiazole-2-carbaldehyde (650 mg), which was used without further purification. LCMS m/z: 232 (M+1)+. 4-(4-lsopropyl-phenyl)-thiazole-2-carbaldehyde (100 mg, 0.43 mmol) and ((thiophen- 2-ylmethyl)-amino) acetic acid t-butyl ester (196mg, 0.86 mmol) were combined according to general procedure D. Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester (100 mg), which was hydrolyzed to provide the HCI salt of {[4-(4-lsopropyl-phenyl)~thiazol-2- ylmethyl]-thiophen-2-ylmethyl-amino}-acetic acid following procedure G1. LCMS m/z: 389 (M+1)+ By analogous methods to those used to prepare Example 145 and those in the relevant above schemes, the following compounds were synthesized.

Example 149 The regioisomeric aminopyrimidines were obtained from 2,4-dichloropyrimidine (150 mg, 1 mmol) and thiophen-2-yl-methylamine (1.1 mmol) by following general procedure P (method 1). (2-chloro-pyrimidin-4-yl)-thiophen-2-ylmethyl-amine was obtained in 60 % yield (135 mg) LCMS (m/z): 227 (M+1)+. (4-Chloro-pyrimidin-2-yl)-thiophen-2-ylmethyl-amine was obtained in 15% yield (34 mg). LCMS (m/z): 227 (M+1)+. [2-(4-lsopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl- amine (142 mg) was obtained by following general procedure Q1 from (2-chloro-pyrimidin-4-yl)-thiophen-2- ylmethyl-amine (130 mg, 0.58 mmol) and 4-isopropylphenylboronic acid (140 mg, 0.86 mmol). LCMS m/z: 311 (M+1)+. [4-(4-lsopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl- amine was obtained by following general procedure Q1 from (4-Chloro-pyrimidin-2-yl)- thiophen-2-ylmethyl-amine and 4-isopropylphenylboronic acid. {[2-(4-lsopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl -amino}-acetic acid tert- butyl ester was prepared (149 mg) from [2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2- ylmethyl-amine (135 mg, 0.44 mmol) and bromoacetic acid tert-butyl ester in THF by following the general procedure F. LCMS m/z: 425 (M+1)+. {[2-(4-lsopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl -amino}-acetic acid was prepared (120 mg)from {[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl -amino}- acetic acid tert-butyl ester (130 mg, 0.35 mmol) by following the general procedure G1. LCMS m/z: 369 (M+1)+. By analogous methods to those used to prepare Example 149 and those in the relevant above Schemes, the following compounds were synthesized. Examples 150 and 152-158 were isolated as the HCI salt. Example 151 was prepared as a neutral compound.

The regioisomeric (2-chloro-pyrimidin-4-yl)-(2,4-dimethoxy-benzyl)-amine and (4- chloro-pyrimidin-2-yl)-(2,4-dimethoxy-benzyl)-amine were obtained from 2,4- dichloropyrimidine (300 mg, 2 mmol) and 2,4-dimethoxybenzylamine (0.33 mL, 2.2 mmol) by following general procedure P (method 1 ). (2-Chloro-pyrimidin-4-yl)-(2,4~dirnethoxy-benzyl)- amine was obtained (347 mg). LCMS m/z: 281 (M+1 )+. (4-Chloro-pyrimidin-2-yl)-(2,4- dimethoxy~benzyl)-amine was obtained (100 mg). LCMS m/z: 281 (M+1 )+. (2,4-Dimethoxy-benzyl)-[2-(4-isopropyl-phenyl)-pyrimidin-4-y l]-amine (323 mg) was obtained, via Suzuki cross-coupling, following general procedure Q1 from (2-chloro- pyrimidin-4-yl)-(2,4-dimethoxy-benzyl)-amine (340 mg, 1.22 mmol) and 4- isopropylphenylboronic acid (300 mg, 1.83 mmol). LCMS m/z: 365 (M+1)+. 2-(4-lsopropyl-phenyl)-pyrimidin-4-ylamine was obtained (155 mg) by following the general procedure R from (2,4-dimethoxy-benzyl)-[2-(4-isopropyl-phenyl)-pyrimidin-4-y l]- amine (310 mg, 0.85 mmol). LCMS m/z: 214 (M+1)+. Example 159 4-Chloro-N-[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-benzenesu lfonamide was obtained (240 mg) by following general procedure C2 from 2-(4-isopropyl-phenyl)-pyrimidin-4-ylamine (150 mg, 0.7 mmol) and 4-chlorobenzenesulfonyl chloride (163 mg, 0.78 mmol). LCMS m/z: 389 (M+1)+. Example 160 4-Chloro-N-[4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-benzenesu lfonamide was prepared (69 mg) by following general methods P, Q1, R and C-2 as explained above by using (4- chloro-pyrimidin-2-yl)-(2,4-dimethoxy-benzyl)-amine (100 mg, 0.36 mmol), 4-isoprpylboronic acid, and 4-chlorobenzenesulfonyl chloride. LCMS m/z: 389 (M+1)+. 1H NMR (CDCI3): δ 1.31 (d, 6H), 3.0 (m, 1H), 7.35 (m, 3H), 7.45 (d, 2H), 7.90 (d, 2H), 8.13 (d, 2H), 8.62 (d, 1H) 10.2 (s, 1H). Example 161 {(4-Chloro-benzenesulfonyl)-[2-(4-isopropyl-phenyl)-pyrimidi n-4-yl]-amino}-acetic acid tert-butyl ester was prepared (97 mg) from 4-chloro-N-[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]- benzenesulfonamide (100 mg, 0.26 mmol) (Prepared in Example 158) and bromoacetic acid tert-butyl ester by following the general procedure S (method 1 ). LCMS m/z: 503 (M+1 )+. {(4-Chloro-benzenesulfonyl)-[2-(4-isopropyl-phenyi)-pyrimidi n-4-yl]-amino}-acetic acid was prepared (80 mg) from {(4-chloro-benzenesulfonyl)-[2-(4-isopropyl-phenyl)-pyrimidi n-4- yl]-amino}-acetic acid tert-butyl ester (90 mg, 0.18 mmol) by following the general procedure G1. LCMS m/z: 447 (M+1)+. 1H NMR (CDCI3): δ 1.2 (d, 6H), 2.98 (m, 1H), 4.98 (s, 2H), 7.2- 8.6 (Ar-H, 10H). By analogous methods to those used to prepare Examples 159-161 and those in the relevant above Schemes, the following compounds were synthesized.

Example 171 4-Chloro-N-[4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-N~( 1 H-tetrazol-5-yl methyl)- benzenesulfonamide was prepared from 4-chloro-N-[4-(4-isopropyl-phenyl)-pyrimidin-2-yl]- benzenesulfonamide via N-alkylation with bromoacetonitrile using general procedure S (method 1) followed by tetrazole formation using general procedure H. LCMS m/z: 471 (M+1 )+. Example 172 (2-Chloro-pyrimidin-4yl)-cyclopentyl-amine and (4-chloro-pyrimidin-2yl)-cyclopentyl- amine were synthesized from 2,4 dichloropyrimidine (1.0 g, 6.7 mmol), cyclopentylamine (860 mg, 10.1 mmol) and DIEA (3.5 ml_, 20.2 mmol) following procedure P, method P2, using THF as solvent. The crude products were purified by silica gel chromatography eluting with DCM/ethyl acetate (9:1) to afford 2-Chloro-pyrimidin-4-yl)-cyclopentyl-amine (598 mg). LCMS m/z: 199 (M+1)+, and (4-chloro-pyrimidin-2-yl)-cyclopentyl-amine (285 mg). LCMS m/z: 199 (M+ 1)+. (4-chloro-pyrimidin-2-yl)-cyclopentyl-annine (100 mg, 0.51 mmol) was reacted with (4- benzyloxyphenyl)boronic acid (173 mg, 0.76 mmol), tetrakis(triphenylphosphino)palladium (44 mg, 0.04 mmol), and aq. 2 N sodium carbonate (1.01 mmol, 0.51 mL) as described in general procedure Q, method Q1, to give 108 mg (62%) of [4-(4-benzyioxy-phenyl)- pyrimidin-2-yl] cyclopentyl-amine. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate, 4:1 then 1 :1. LCMS m/z: 346 (M+1)+. [4-(4-benzyloxy-phenyl)-pyrimidin-2-yl] cyclopentyl-amine (108 mg, 0.313 mmol) was reacted with methyl-3-(bromomethyl) benzoate (107 mg, 0.47 mmol) and NaH (60 % suspension, 25 mg, 0.626 mmol) following general procedure S, method S2. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 to give 133 mg of 3-({[4-(4-benzyloxy-phenyl)-pyrimidin-2-yl] cyclopentyl-amine}-methyl)-benzoic acid methyl ester. LCMS m/z: 495 (M+1)+. To a MeOH-DCM solution (4:1 , 4 mL) of 3-({[4-(4-benzyloxy-phenyl)-pyrimidin-2-yl] cyc!opentyl-amine}-methyl)-benzoic acid methyl ester (127 mg, 0.26 mmol) was added 10% Pd/C (28 mg), and the reaction mixture was stirred at room temperature for 2 h under a hydrogen atmosphere (balloon). The mixture was filtered through a pad of Celite and then concentrated. The 3-({cyclopentyl-[4-(4-hydroxy-phenyl)-pyrimidin-2-yl]-amino} -methyl)- benzoic acid methyl ester obtained was used without further purification. LCMS m/z: 405 (M+1)+. To a THF (2 mL) solution of 3-({cyclopentyl-[4-(4-hydroxy-phenyl)-pyrimidin-2-yl]- amino}-methyl)-benzoic acid methyl ester (44 mg, 0.11 mmol) was added frans-4-methyl- cyclohexanol (12.5 mg, 0.11 mmol) and triphenylphosphine (27 mg, 0.11 mmol). After the mixture was cooled 5 min. in an ice bath, diisopropyl azodicarboxylate (DIAD, 21.5 μL, 0.11 mmol) was added. The solution was stirred at room temperature until complete. Water was added, and the mixture was extracted with ethyl acetate (3 x 2 mL). The ethyl acetate layer was dried over Na2SO4 and concentrated. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 9:1 then 4:1 to give 16 mg (30%) of 3- [(cyclopentyl-{4-[4-(c/s-4-methyl-cyclohexyloxy)-phenyl]-pyr imidin-2-yl}-amino)-methyl]- benzoic acid methyl ester. LCMS m/z: 501 (M+1)+. This product was hydrolyzed according to general procedure T. The 3-[(cyclopentyl- {4-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-pyrimidin-2-yl}-a mino)-methyl]-benzoic produced was then converted to its corresponding HCI salt following general procedure G2 to give 3- [(cyclopentyl-{4-[4-(c/s-4-methyl-cyclohexyloxy)-phenyl]-pyr imidin-2-yl}-amino)-methyl]- benzoic acid hydrochloride.^ 6 mg, 94%). LCMS (m/z): 487 (M+1)+. Example 173 (2-chloro-pyrimidin-4-yl)-cyclopentylamine (100mg, 0.51 mmol) was reacted with (4- benzyloxyphenyl)boronic acid (173 mg, 0.76 mmol); tetrakis(triphenylphosphino)palladium (44 mg, 0.04 mmol), and aq. 2 N sodium carbonate (1.01 mmol, 0.51 mL) as described in general procedure Q, method Q2, to give 164 mg of [2-(4-benzyloxy-phenyl)-pyrimidin-4-yl]- cyclopentyl-amine. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 then 1:1. LCMS m/z: 346 (M+1)+. [2-(4-benzyloxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amine (164 mg, 0.475 mmol) was reacted with methyl-3-(bromomethyl) benzoate (163 mg, 0.71 mmol) and NaH (60 % suspension, 38 mg, 0.95 mmol) following general procedure S, method S2. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 then 2:1 , and 116 mg of 3-({[2-(4-benzyloxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amin o}-methyl)-benzoic acid methyl ester was obtained. LCMS m/z: 495 (M+1)+. To a MeOH-DCM solution (4:1, 4 mL) of 3-({[2-(4-benzyloxy~phenyl)-pyrimidin~4-yl]~ cyclopentyl-amino}-methyl)-benzoic acid methyl ester (116 mg, 0.235 mmol) was added 10% Pd/C (25 mg), and- the reaction mixture was stirred at room temperature for 2 h under a hydrogen atmosphere (balloon). The mixture was filtered through a pad of Celite and then concentrated. The 3-({cyclopentyl-[2-(4-hydroxy-phenyl)-pyrimidin-4-yl]-amino} -methyl)- benzoic acid methyl ester obtained was used, without further purification. LCMS m/z: 405 (M+1)+. To an acetone (3 mL) solution of 3-({cyciopentyl-[2-(4-hydroxy-phenyl)-pyrimidin-4- yl]-amino}-methyl)-benzoic acid methyl ester (23 mg, 0.057 mmol) was added (bromomethyl)cyclohexane (11 mg, 0.063 mmol), K2CO3 (36 mg, 0.26 mmol) and tetrabutyammonium bromide (0.4 mg, 0.003 mmol). The resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 100 0C for 30 min. After cooling to room temperature the reaction mixture was filtered, and the residue was washed with acetone (4 mL). The solution was concentrated, and the crude solid was purified by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 then 2:1 to yield 22 mg of 3-({[2-(4- cyclohexylmethoxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amino} -methyl)-benzoic acid methyl ester. LCMS m/z: 501 (M+1)+. This product was hydrolyzed according to general procedure T. The 3-({[2-(4- cyclohexylmethoxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amino} -methyl)-benzoic acid produced was then converted to its corresponding HCI salt following general procedure G2 to give 3-({[2-(4-cyclohexylmethoxy-phenyl)-pyrimidin-4-yl]-cyclopen tyl-amino}-methyl)- benzoic acid hydrochloride (22 mg). LCMS m/z: 487 (M+1 )+. Example 174 [4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-thiophen-2-ylιnethy l-amine (50 mg, 0.16 mmol) (prepared in Example 149) was reacted with methyl-4-(bromomethyl) benzoate (55 mg, 0.24 mmol) and NaH (60% suspension, 13 mg, 0.32 mmol) following general procedure S, method S2. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 to give 42 mg of 4-({[4-(4-isopropyl-phenyl)-pyrimidin-2-yl]- thiophen-2-ylmethyl-amino}-methyl)-benzoic acid methyl ester. LCMS m/r. 459 (M+1)+. This ester was hydrolyzed according to general procedure T. The hydrolysis product was then converted to its corresponding HCI salt following general procedure G2. LCMS A77/z: 445 (M+1)+. By analogous methods to those used to prepare Example 174 and those in the relevant above schemes, the following compounds were synthesized. Examples 175-181 in the table below were prepared in the HCI salt form using general procedure G2.

Example 182 To a THF (2 mL) solution of 3-({cyclopentyI-[4-(4-hydroxy-phenyl)-pyrimidin-2-yl]- amino}-methyl)-benzoic acid methyl ester (39 mg, 0.10 mmol) (prepared in Example 172) was added c/s-4-methyl-cyclohexanol (11 mg, 0.10 mmol) and triphenylphosphine (25 mg, 0.10 mmol). After the mixture was cooled 5 min. in an ice bath, diisopropyl azodicarboxylate (DIAD, 19.1 μl_, 0.10 mmol) was added. The solution was stirred at room temperature until complete. Water was added, and the mixture was extracted with ethyl acetate (3 x 2 mL). The ethyl acetate layer was dried over Na2SO4 and concentrated. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 9:1 then 4:1 to give 16 mg of 3-[(cycloperityl-{4-[4-(fra/is-4-methyl-cyclohexyloxy)-pheny l]-pyrimidin-2-yl}-amino)- methyl]-benzoic acid methyl ester. LCMS m/z: 501 (M+1)+. This ester was hydrolyzed according to general procedure T. The hydrolysis product was then converted to its corresponding HCI salt following general procedure G2 (16 mg). LCMS m/z: 487 (M+1)+. Example 183 [2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl- amine (50 mg, 0.16 mmol) (prepared in Example 149) was reacted with methyl-4-(bromomethyl) benzoate (55 mg, 0.24 mmol) and NaH (60% suspension, 13 mg, 0.32 mmol) following general procedure S, method S2. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 4:1 to give 25 mg of 4-({[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]- thiophen-2-ylmethyl-amino}-methyl)-benzoic acid methyl ester. LCMS m/z: 459 (M+1 )+. By analogous methods to those used to prepare Example 183 and those in the relevant above schemes, the following compounds were synthesized. Examples 184-188 in the table below were prepared in the HCI salt form using general procedure G2. Examples 187 and 188 were prepared as the sodium salt via general procedure J.

Example 189 [4_(4-lsopropyl-phenyl)-thiazol-2-yl]-[2-(1H-tetrazol-5-yl)- ethyl]-thiophen-2-ylmethyl- amine was prepared following general procedure H using 3-{[4-(4-isopropyl-phenyl)-thiazol- 2-yl]-thiophen-2-ylmethyl-amino}-propionitrile (278 mg, 0.756 mmol), sodium azide (657 mg, 99%, 10 mmol), ammonium chloride (535 mg, 10 mmol) and DMF (3 ml_). Purification by flash chromatography (ethyl acetate/hexanes 1 :1 , with 0.5% v/v acetic acid) gave the product compound (110 g, 0.268 mmol). 1H-NMR (400 MHz, CDCI3): 7.75-7.77(m, 2H), 7.26-7.33(m, 3H), 6.98-7.06(m, 2H), 6.75(s, 1H), 4.74(s, 2H), 4.23(t, 2H), 3.40(t, 2H), 2.95(sept, 1H), 1 l28(d, 6H); LCMS m/z: 411 (M+1)+. Example 190 2-({[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethy l-amino}-methyl)- benzonitrile was prepared by stirring (4-(-isopropyl-pheny!)-thiazol-2-yl)-thiophen-2-ylmethyl- amine (100mg, 0.31 mmol), NaH (26 mg, 60%, 0.62 mmol), and 2-bromomethylbenzonitrile (72mg, 0.372 mmol) in THF (50 mL) at room temperature. After 3h, the reaction mixture was concentrated under high vacuum. The crude product used without purification. [4-(4-lsopropyl-phenyl)-thiazol-2-yl]-[2-(1H-tetrazol-5-yl)- benzyl]-thiophen-2-ylmethyl- amine (6.0 mg) was prepared following general procedure H from the corresponding nitrile (130 mg, 0.31 mmol), ammonium chloride (3.1 mmol) and sodium azide (3.1 mmol). Purification (Silica gel, methanol/DCM 3:97) provided the product. LCMS m/z: 474 (M+1)+ Example 191 N-[2-({[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylme thyl-amino}-methyl)- benzoyl] methanesulfonamide was prepared following procedure K using 2-({[4-(4-lsopropyl- phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-methyl)-ben zoic acid (200 mg, 0.44 mmol), CDI (215 mg, 0.133 mmol), DBU (102 μl, 0.66. mmol), and methane sulfonamide (90 mg, .0.888 mmol). Purification (Silica gel, methanol/DCM 3:97) provided the product (100 mg). LCMS m/z: 527 (M+1)+- Example 192 A mixture of 3-{cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}- propionic acid (100mg, 0.28 mmol), diphenyl phosphoryl azide (70 ul, 0.25 mmol) and DlEA (150 μl) was heated in CH3CN at 6O0C for 1 hour. After cooling to room temperature methane sulfonamide (50 mg, 0.52 mmol) was added and reaction mixture was stirred. After 16 h, the reaction mixture was concentrated in high vacuum. The crude residue was purified on a silica gel column (ethyl acetate/hexane 1:1) to afford 1-(2-{cyclopentyl-[4-(4-isopropyl- phenyl)-thiazol-2-yl]-amino}-ethyl)-3-methanesulfonyl-urea (25 mg). LCMS m/z: 452 (M+1)+. Example 193 A mixture of 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}- propionic acid (50mg, 0.14 mmol), diphenyl phosphoryl azide (50 uL, 0.18 mmol) and DlEA (100 μl_) was heated in CH3CN at 6O0C for 1 hour. After cooling to room temperature methane sulfonamide (30 mg, 0.32 mmol) was added and reaction mixture was stirred. After 16 h, the reaction mixture was concentrated in high vacuum. The crude residue was purified on silica gel column (ethyl acetate/hexane 1 : 1 ) to afford(2-{[4-(4-lsopropyl-phenyl)-thiazol-2- yl]-thiophen-2-ylmethyl-amino}-ethyl) 3-methanesulfonyl-urea (15 mg). LCMS m/z: 480 (M+1f Example 194 LDA (1.5 nil, 2.0 M solution in THF) added to THF solution of 3-(cyclopentyl-(4-(4- isopropyl-phenyl)-2-yl)-amino)-propionic acid methyl ester (373.0mg, 1.0 mmol) at -780C. After 30 min., methyl iodide (75 μl, 1.2 mmol) was added. After 90 min., the cooling bath was removed and reaction warmed to room temperature. The reaction was quenched with ammonium chloride solution and extracted with Et2O (1X50 ml). The organic layer was dried (MgSO4), filtered and concentrated. The residual oil purified on silica gel column to afford ester (150 mg). The ester was hydrolyzed to the title compound following general procedure T to give 3-{Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}- 2-methyl-propionic acid (150 mg). LCMS m/z: 374 (M+ 1)+- Example 195 LDA (1.0 ml, 2.0 M solution in THF) added to THF solution of 3-(cyclopentyl-(4-(4- isopropyl-phenyl)-2-yl)-amino)-propionic acid methyl ester (250. Omg, 0.67 mmol) at -780C. After 30 min., benzyl bromide (120 μL, 1.0 mmol) was added. After 90 min., the cooling bath removed and the reaction was warmed to room temperature, quenched with ammonium chloride solution, extracted with Et2O (1X50 ml), organic layer dried (MgSO4), and filtered and concentrated under high vacuum. The residual oil was purified on silica gel column to afford ester (50 mg). The ester was hydrolyzed to the title compound following general procedure T to give 2-Benzyl-3-{cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl ]-amino}- propionic acid (40 mg) LCMS m/z: 450 (M+1)+. Example 196 4-{Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}- butyric acid was prepared according to general procedure B using 4-(1-cyclopentyl-thioureido)-butyric acid methyl ester (70 mg, 0.3 mmol) and 2-bromo-4'-isopropylacetophenone (80.0 mg, 0.3 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following general procedure T. LCMS m/z: 374 (M+1)+. Example 197 To the THF solution of [4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl- amine (150.0 mg, 0.5 mmol) and methyl 5-bromopentaoate (215 μl_, 0.1.5 mmol) was added NaH (60 mg, 60%, 0.1.5 mmol) and the resulting mixture was heated at 6O0C for 5h, after cooling to room temperature methanol (2.0ml). NaOH (2.0 ml, 1.0 M) added and mix was stirred at room temperature for 15 h. HCI added dropwise to pH 7.0. The acid was extracted with EtOAc (2X20ml), combined organic extracts dried (Na2SO4), filtered, concentrated, and purified on silica gel column. The sodium salt was made following procedure J to afford the sodium 5-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}-pentanoate (110 mg). LCMS m/z: 416 (M+1)\ Example 198 A mixture of 6-methyl-pyridine-2-carboxylic acid ethyl ester (1.65g, 10 mmol), NBS (1.77g, 10 mmol), and benzoyl peroxide (100 mg) in carbon tetrachloride (20ml) was refluxed for 14 h. After cooling to room temperature, the reaction mixture was partitioned between diethyl ether and water (120ml, 4:1 ), organic layer was washed with water (2X20 ml), brine, dried (MgSO4), filtered and concentrated to give 6-bromomethyl-pyridine-2- carboxylic acid ethyl ester (2.4 g) which was used without further purification. LCMS m/z: 245 (M+1)+. 6-({[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethy l-amino}-methyl) pyridine- 2-carboxylic acid ethyl ester was prepared following general method S2 using (4-(-isopropyl- phenyl)-thiazol-2-yl)-thiophen-2-ylmethyl-amine (62mg, 0.20 mmol), 6-bromomethyl-pyridine- 2-carboxylic acid ethyl ester (60 mg, 0.24 mmol) and NaH (34 mg, 60%, 0.84 mmol). , Purification (Silica gel, ethyl acetate/hexane 1:4) provided the ester, which was hydrolyzed following general procedure T. Sodium 6-({[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2- ylmethyl-amino}-methyl) pyridine-2-carboxylate was made following procedure J. LCMS m/z: 451 (M+1)+. Example 199 To a THF solution of [4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-am ine (80 mg, 0.25 mmol) and tert-butyl bromoacetate (41 μL, 0.28 mmol) was added NaH (15 mg, 60%, 0.38 mmol) and the resulting mixture was stirred at room temperature for 30 min. The reaction was quenched with brine and extracted with ethyl acetate (3 X 5 ml_). Combined ethyl acetate extracts were dried over sodium sulfate, concentrated and purified on silica gel column to afford 2-{thiophen-2-ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl] -amino}acetic acid tert-butyl ester (75 mg). LCMS m/z: 430 (M+1)+. 2-{Thiophen-2-ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl] -amino}acetic acid hydrochloride was prepared (63 mg) following general procedure G1 using 2-{thiophen-2- ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}acetic acid tert-butyl ester (66 mg, 0.155 mmol) and 4 N HCI solution in dioxane (1.0 ml_). LCMS m/z: 474 (M+1)+. Example 200 3-{[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}-propane-1 - sulfonic acid was prepared following general method S2 using (4-(-isopropyl-phenyl)-thiazol- 2-yl)-thiophen-2-ylmethyl-amine (54mg, 0.17 mmol), [1 ,2]-oxathiolane 2,2-dioxide (26.0 mg, 0.2 mmol) and NaH (20 mg, 60%, 0.5 mmol). After 2 h, the volatiles were evaporated, and the residue was washed with hexane (2X5ml) and then partitioned between ethyl acetate and water. The aqueous layer was adjusted to pH 6, and extracted with ethyl acetate (2X10 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated to give the product (40 mg). LCMS m/z: 437 (M+1 )+. i Example 201 3-[(8H-lndeno[1 ,2-d]thiazol-2-yl)-thiophen-2-ylmethyl-amino]-propionic acid tert-butyl ester was prepared (35mg) following general procedure B using 2-bromo-indan-1-one (22 mg, 0.1 mmol), and 3-(1-thiophen-2-ylmethyl-thioureido)-propionic acid tert-butyl ester (30 mg, 0.1 mmol). LCMS m/z: 414 (M+1)+. S-^δH-lndenoti^-dlthiazol^-yO-thiophen^-ylmethyl-aminol-pro pionic acid hydrochloride was prepared (32 mg) following general procedure G1 using 3-[(8H- indeno[1 ,2-d]thiazol-2-yl)-thiophen-2-ylmethyl-amino]-propionic acid tert-butyl ester (35 mg, 0.085 mmol) and 4 N HCI solution in dioxane (1.0 mL). LCMS m/z: 358 (M+1)+. 1H NMR (CD3OD, 400 MHz): δ 2.8 (t, 3H), 3.80 (s, 2H) 3.9 (t, 2H), 5.0 (s, 2H), 7.08 (dd, 1H), 7.21 (dd, 1 H), 7.28 (t, 1 H), 7.38 (t, 1 H), 7.42 (dd, 1 H), 7.56 (dd, 1 H), 7.7 (dd, 1 H). Example 202 4-Phenylcyclohexanone (401 mg, 2.30 mmol) was dissolved in EtOAc (10 mL) and CuBr2 ( 509 mg, 2.29 mmol) was added. The reaction mixture was stirred at 4O0C for 3 h followed by room temperature overnight. Ethyl acetate (15 mL) and hexane (15 mL) were added and the organic layer was washed with water (4x20 mL) followed by brine (20 mL). The solution was dried over MgSO4, filtered, and concentrated. The crude product (mixture of cis and trans isomers) was used without further purification. The 2-bromo-4-phenylcyclohexanone (2.30 mmol) and 3-(1-Cyclopentyl-thioureido)- propionic acid tert-butyl ester (257 mg, 0.945 mmol) were combined as in general procedure 5 013386

B (13 imL THF, 40 °C, 15 h). After aqueous workup, the crude product was purified by silica gel chromatography (gradient, hexane -> 10% EtOAc-hexane) to afford 3~[cyclopentyl-(6- phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amino]-propioni c acid tert-butyl ester (398 mg). The ester was dissolved in CH2CI2 (2 mL) and TFA (2 mL) was added. The reaction mixture was stirred at room temperature, until the starting material, was consumed by TLC. The volatiles were removed and the residue was dissolved in MeOH. NaOH solution (0.90 mmol) was added followed by half-saturated NaCl (20 mL). The aqueous layer was extracted with CH2CI2 (3x15 mL) and dried over MgSO4 to provide 3-[Cyclopentylcyclopentyl- (6-phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amino]-propi onic acid. The sodium salt was prepared by general procedure J and triturated with hexane to yield 3-[ cyclopentyl-(6- phenyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-amino]-propioni c acid, sodium salt (336 mg) LCMS m/z: 372 (M+1)+. Example 203 To the mixture of fluoro-N,N,N",N"-tetramethylformamidinium hexafluorophosphate (TFFH) (290 mg, 1.1 mmol) and thiophen-2-acetic acid (156 mg, 1 mmol) at 0° C was added diisopropylethylamine (0.35 mL, 2 mmol) and stirred at same temperature for 20 min. before adding 2-aminothiazole (261 mg, 1.2 mmol). The reaction mixture was warmed to room temperature and stirred for 12 h. The mixture was concentrated and loaded onto silica gel column to provide N-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-2-thiophen-2-yl-acet amide (273 mg). LCMS m/z: 344 (M+1)+. To N-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-2-thiophen-2-yl-acet amide (270 mg, 0.79 mmol) was added diborane in THF (1.6 mL, 1 M solution, 1.58 mmol). The mixture was stirred at room temperature for 2 h. Saturated NaHCO3 solution was added, and the rnixture was extracted into ethyl acetate (3 X 5 mL). Combined ethyl acetate extracts were dried over Na2SO4, concentrated and purified on silica gel column to afford [4-(4-isopropyl- phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-ethyl)-amine (103 mg). LCMS m/z: 330 (M+1)+. To a THF solution of [4-(4-isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-ethyl )- amine (100 mg, 0.3 mmol) and ethyl bromopropionate (42 μL, 0.33 mmol) was added NaH (18 mg, 60%, 0.45 mmol). The mixture was stirred at room temperature for 30 min, and the excess NaH was quenched with brine and extracted into ethyl acetate (3 X 5 mL). The combined ethyl acetate extracts were dried over sodium sulfate, concentrated and purified on silica gel column to afford 3-[[4-(4-isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-et hyl)- amino]~propionic acid ethyl ester (98 mg). LCMS m/z: 430 (M+1 )+. To the 3-[[4-(4-isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-et hyl)-amino]-propionic acid ethyl ester (95 mg, 0.22 mmol) was added LiOH (3 mL; 2N LiOH-MeOH-THF = 1:1 :4) and the reaction was stirred at room temperature for 4h before acidifying with 1 N HCI. i Brine was added, and the mixture was extracted with DCM (3 X 10 ml). The combined extracts were dried over Na2SO4, concentrated and purified on silica gel column to provide 3-[[4-(4- isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-ethyl)-amin o]-propionic acid hydrochloride salt (58 mg). LCMS m/z: 402 (M+1)+. Example 204 3-[[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-(3-thiophen-2-yl-pr opyl)-amino]-propionic acid hydrochloride salt was prepared (50 mg) following the procedure described in Example 202 using 4-(4-lsopropyl-phenyl)-thiazol-2-yl-amine (261 g, 1.2 mmol), thiophen-2-propionic acid (165 mg, 1 mmol), TFFH (290 mg, 1.1 mmol), diisopropylethylamine (0.35 ml_, 2 mmol) diborane-THF (1.6 mL, 1M, 1.6 mmol), NaH (18 mg, 60%, 0.45 mmol), ethyl bromopropionate (42 μL, 0.33 mmol) and LiOH (3 mL, aq 2N LiOH-MeOH-THF 1: 1: 4). The HCI salt was formed as in the above experiment using 1N HCI in the workup procedure. LCMS m/z: 416 (M+1)+. Example 205 4-(4-lsopropyl-phenyl)-thiazol-2-yl amine (90 mg, 0.41 mmol) was acylated in CH2CI2 using cyclobutane carbonyl chloride (60 μL, 0.52 mmol, 1.25 eq.) in the presence of excess pyridine. The reaction was quenched with sat. NH4CI1 extracted with EtOAc and dried over MgSO4. Purification by silica gel chromatography (10% EtOAc in hexanes) afforded 95 mg (80%) of cyclobutanecarboxylic acid [4-(4-isopropyl-phenyl)-thiazol-2-yl]-amide. The thiazole-amide (95 mg, 0.32 mmol) was dissolved in THF (3 mL), cooled to 0 0C and treated with 1.0 mL of borane (1 M THF, 3 eq.). The reaction was stirred for 24 h at room temperature. After the excess borane was quenched with MeOH, the reaction mixture was concentrated, diluted with EtOAc, and washed with sat. NaHCO3. The organic layer was dried over MgSO4. Purification by silica gel chromatography (0 - 5% EtOAc in hexanes) yielded 28 mg cyclobutylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine . Alkylation of the above N-alkyl aminothiazole was accomplished with NaH (5 mgs, 1.8 eq.) and methyl 4-(bromomethyl)benzoate (27 mg, 1.8 eq) according to general procedure S2. Purification provided 3-({cyclobutylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2- yl]-amino}-methyl)-benzoic acid methyl ester 18.5 mg. Hydrolysis of the above benzoic ester as described in general procedure T afforded 12 mg of 3-({cyclobutylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-a mino}-methyl)-benzoic acid. LCMS m/z: 422 (M + I)+. Example 206 4-(4-lsopropyl-phenyl)-thiazol-2-yl amine (100 mg, 0.46 mmol) was acylated in CH2CI2 using cyclohexane carbonyl chloride (85 μL, 0.57 mmol, 1.25 eq.) in the presence of excess pyridine. The reaction was quenched with sat. NH4CI, extracted with EtOAc and dried over MgSO4: Purification by silica gel chromatography (10% EtOAc in hexanes) afforded 123 mgs cyclohexanecarboxylic acid [4-(4-isopropyl-phenyl)-thiazol-2-yl]-amide.

133 The thiazole-amide (95 mg, 0.37 mmol) was dissolved in THF (3 ml_), cooled to 00C and treated with 1.3 mL of borane (1 M THF, 3 eq.). The reaction was stirred for 24 h at room temperature. After the excess borane was quenched with MeOH, the reaction mixture was concentrated, diluted with EtOAc and washed with sat. NaHCO3. The organic layer was dried over MgSO4. Purification by silica gel chromatography (0 - 5% EtOAc in hexanes) yielded 40 mg cyclohexylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amine . Alkylation of the above N-alkyl aminothiazole was accomplished with NaH (7 mg, 1.8 eq.) and methyl 4-(bromomethyl)benzoate (34 mg, 1.8 eq.) according to general procedure S2. Purification provided 3-({cyclohexylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-a mino}- methyl)-benzoic acid methyl ester 39 mg. Hydrolysis of the above benzoic ester as described in general procedure T afforded 19 mg of 3-({cyclohexylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-a mino}-methyl)-benzoic acid. LCMS m/z: 450 (M + I)+. Example 207 To the methanol solution of 1 H-indazole-3-carboxylic acid (162 mg, 1 mmol) was added 4N HCI in dioxane (2 mL) and the mixture was stirred at the room temperature for 24 h. After evaporation of the volatiles, the mixture was partitioned between aqueous NaHCO3 solution and ethyl acetate. The aqueous phase was extracted with ethyl acetate (2 X 15 mL), and the combined organic layer was dried over sodium sulfate. The volatiles were removed, and the residue was filtered over silica gel to provide 1 H-lndazole-3-carboxylic acid methyl ester (123 mg). LCMS m/z: 177 (M+1)+. 1-Thiocarbamoyl-1 H-indazole-3-carboxylic acid methyl ester was prepared (113 mg) following general procedure D using 1 H-lndazole-3-carboxylic acid methyl ester (120 mg, 0.69 mmol), Fmoc isothiocyanate (213 mg, 0.76 mmol), and diethyl amine (0.5 rηL). LCMS m/z: 236 (M+1)+. 1-[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-1 H-indazole-3-carboxylic acid methyl ester was prepared (150 mg) following general procedure B using 2-bromo-1-(4-isopropyl)-ethanone (110 mg, 0.46 mmol), and 1-thiocarbamoyl-1 H-indazole-3-carboxylic acid methyl ester (110 mg, 0.46 mmol). LCMS m/z: 379 (M+1)+. To the 1 -[4-(4-isopropyl-phenyl)-thiazol-2-yl]-1 H-indazole-3-carboxylic acid methyl ester (150 mg, 0.22 mmol) was added LiOH (5 mL; 2N LiOH-MeOH-THF = 1:1:4) and stirred at room temperature for 4h before acidifying with 1 N HCI. Brine was added and the aqueous was extracted with DCM (3 X 15 ml). Combined extracts were dried over Na2SO4, concentrated and purified on silica gel column to provide 1-[4-(4-!sopropyl-phenyl)-thiazol-2- yl]-1 H-indazole-3-carboxylic acid hydrochloride salt (48 mg). LCMS m/z: 365 (M+1 )+. Example 208 To 4-(4-lsopropyl-phenyl)-thiazol-2-ylamine (50 mg, 0.23 mmol) in THF (1 mL) was added 4-chlorobenzenesulfonyl isocyanate (36 μl_, 0.25 mmol). Purification was accomplished by silica gel chromatography to yield N-(4-(4-isobutyl-phenyl)-thiazol-2-yl]-N'- (4-chloro-benzenesulfonyl) urea (85 mg). LCMS m/z: 437 (M+1 )+; 1H NMR (CDCI3, 400 MHz): δ 1.27 (d, 6H); 2.95 (m, 1H), 6.75 (s, 1H), 7.3 (m, 2H), 7.5 (m,2 H), 7.6 (m, 2H), 8.0 (m, 2H). Example 209 (2-Chloro-pyrimidin-4-yl)-thiophen-2-ylmethyl-amine and (4-chloro-pyrimidin-2-yl)- thiophen-2-ylmethyl-amine were obtained from 2,4-dichloropyrimidine (7.5 g, 50.34 mmol) and thiophen-2-yl-methylamine (6.25 g, 55.22 mmol) by following general procedure P, method P1. Purification was carried out by silica gel chromatography (DCM/ethyl acetate, 9:1 then 3:1) to afford (2-chloro-pyrimidin-4-yl)-thiophen-2-ylmethyl-amine (6.58 g). LCMS m/z: 227 (M+1)+; and (4-Chloro-pyrimidin-2-yl)-thiophen-2-ylmethyl-amine (1.55 g). LCMS m/z: 227 (M+1 )+. [4-(4-lsopropyl-phenyl)-pyrimidin-2-yl]-thiophen-2-ylmethyl- amine (1.02 g, 99% yield) was obtained by following general procedure Q, method Q1, using (4-chloro-pyrimidin-2-yl)- thiophen-2-ylmethyl-amine (750 mg, 3.32 mmol), 4-isopropylphenylboronic acid (817 mg, 4.98 mmol), tetrakis(triphenylphosphino)palladium (288 mg, 0.25 mmol), and'aq. 2 N sodium carbonate (6.64 mmol, 3.32 mL). Purification was carried out by silica gel chromatography eluting with DCM/ethyl acetate (9:1 then 4:1). LCMS m/z: 311 (M+1)+. To a solution of [4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-thiophen-2-ylmethyl- amine (50 mg, 0.16 mmol) in DCM (2 mL) was added triethylamine (33 μL, 0.24 mmol) and 4- (ethoxycarbonyl)phenyl isocyanate (34 mg, 0.18 mmol). The resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 1000C for 30 min. After cooling to room temperature the solvent was evaporated. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 9:1 to give 11 mg of 4-{3-[4-(4-lsopropyl- phenyl)-pyrimidin-2-yl}-3-thiophen-2-ylmethyl-ureido}-benzoi c acid ethyl ester. LCMS m/z: 502 (M+1 )+. This product was hydrolyzed according to general procedure T to provide 4-{3-[4-(4- isopropyl-phenyl)-pyrimidin-2-yl}-3-thiophen-2-ylmethyl-urei do}-benzoic acid. The acid was then converted to its corresponding HCI salt following general procedure G2 to give 4-{3-[4- (4-isopropyl-phenyl)-pyrimidin-2-yl}-3-thiophen-2-ylmethyl-u reido}-benzoic acid hydrochloride (10 mg). LCMS m/z: 474 (M+1 )+. Example 210 To a solution of [4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-thiophen-2-ylmethyl- amine (50 mg, 0.16 mmol) in DCM (2 mL) was added triethylamine (33μL, 0.24 mmol) and methyl 2- isocyanatobenzoate (32 mg, 0.18 mmol). The resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 1000C for 30 min. After cooling to room temperature the solvent was evaporated. Purification was carried out by silica gel chromatography eluting with hexanes/ethyl acetate 9:1 to give 2 mg of 2-{3-[4-(4-isopropyl-phenyl)-pyrimidin-2-yl}-3- thiophen-2-ylmethyl-ureido}-benzoic acid methyl ester. LCMS m/z: 488 (M+1)+. This product was hydrolyzed according to general procedure T to provide 2-{3-[4-(4- isopropyl-phenyl)-pyrimidin-2-yl}-3-thiophen-2-ylmethyl-urei do}-benzoic acid. The acid was then converted to its corresponding HCI salt following general procedure G2 to give 2-{3-[4- (4-isopropyl-phenyl)-pyrimidin-2-yl}-3-thiophen-2-ylmethyi-u reido}-benzoic acid hydrochloride (1.4 mg). LCMS m/z: 474 (M+1 )+. Example 211 [4-(4-lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-am ine (50 mg, 0.16 mmol), 4-(chlorosulfonyl)benzoic acid (53 mg, 0.24 mmol), triethylamine (45 μL, 0.32 mmol), and DMAP (2 mg, 0.016 mmol) were combined in DCM (2 mL). The resulting reaction mixture was heated in a CEM Exployer PLS™ microwave at 100 0C for 30 min. After cooling to room temperature; saturated NaHCO3 (aq) solution (5 mL) was added. The mixture was extracted with DCM (2 x 4 mL). The combined organic layer was dried over Na2SO4 and concentrated. Purification of the crude product was carried out using silica gel chromatography eluting with DCM/MeOH 9:1, yielding 4-{[4-(4-isopropyl~phenyl)thiazol-2-yl]- thiophen-2-ylmethyl-sulfamoyl}-benzoic acid. LCMS m/z: 500 (M+1)+. Example 212 , | 3-Amino-benzoic acid methyl ester (455 mg, 3.0 mmol), thiophene carboxaldehyde (290 μL, 3.15 mmol) and sodium triacetoxyborohydride (765 mg, 3.6 mmol) were combined according to general procedure D. 189 mg of the crude 3-[(thiophen-2~ylmethyl)-amino]- benzoic acid methyl ester (0.75 mmol) was treated with 1 eq. Fmoc-NCS to afford 206 mg 3- (1-thiophen-2-ylrnethyl-thioureido)-benzoic acid methyl ester after purification. Condensation of the 1-alkyl-1-aryl thiourea (100 mg, 0.32 mmol) with 2-bromo-1-(4- isopropyl-phenyl)-ethanone (80 mg, 0.32 mmol) according to general procedure B afforded 51 mg 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl -amino}-benzoic acid methyl ester after purification. The ester was hydrolyzed following general procedure T to provide 3-{[4-(4- lsopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-b enzoic acid (18 mg) after column chromatography (25% EtOAc in hexanes). won iy yσncιc.1 ^iuuouui c o, o. i my of 3-{[4-(4-isopropyl-phenyl)-thiazol-2-yl]- thiophen-2-ylmethyl-amino}-benzoic acid sodium salt was prepared from 3.0 mg of the corresponding acid. LCMS m/z: 436 (M+1 )+. Example 213 4-(4-lsopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) was prepared following general procedure T using the corresponding ethyl ester (170 mg, prepared in example 145). 4-(4-lsopropyl-phenyl)-thiazole-2-carbonyl chloride was prepared by refluxing a mixture of 4-(4-lsopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) and oxalyl chloride (300 μl) in chloroform (5 ml_). After 3 h, the volatiles were evaporated and the residue was dried under high vacuum to provide the acid chloride (50 mg). 4-(4-lsopropyl-phenyl)-thiazole-2-carbonyl chloride (50 mg), 3-Cyclopentylamino- propionic acid tert-butyl ester (60mg), TEA (200 ul), and DMAP (20 mg) in THF were combined at room temperature. After 4 h, the reaction mixture was partitioned between EtOAc and water (50 ml, 4:1 ), the EtOAc layer was washed with brine, dried (MgSO4), filtered, and concentrated. The residue was purified on silica gel column (EtOAc/hexane 5:95) to afford the ester (50 mg), which was hydrolyzed to the acid following procedure G1 to provide 3-{cyclopentyl-[4-(4-isopropyl-phenyl)-thiazole-2-carbonyl]- amino}-propionic acid. LCMS m/z: 388 (M+1 )+. Example 214 i-Thiocarbamoyl-piperdine-S-carboxylic acid ethyl ester (400 mg) was prepared following general procedure D using piperdine-3-carboxylic acid ethyl ester (315 mg, 2.0 mmol), and Fmoc-isothiocyanate (562 mg, 2.0 mmol). Purification: (Silica gel, ethyl acetate/hexane 1:1). LCMS m/z 217.0 (M+1)+ A mixture of the above i-thiocarbamoyl-piperdine-3-carboxylic acid ethyl ester (200 mg, 0.925 mmol) and 2-bromo-4'-isopropylacetophenone (220 mg, 0.925 mmol) in ethanol (5 ml) was heated at 6O0C for 2h. The reaction was concentrated and partitioned between Et2O and sodium bicarbonate (1:1). The organic phase was dried (MgSO4), filtered and concentrated under high vacuum. The crude residue was purified (Silica gel, ethyl acetate/hexane 5:95) afford ester (100 mg), which was hydrolyzed according to the general procedure T to give 1-[4-(4-lsopropyl-phenyl)-thiazol-2-yl]-piperidine-3-carboxy lic acid (90 mg). LCMS m/z: 332 (M+1)+. Example 215 4-Thioureido-cyclohexanecarboxylic acid methyl ester (150 mg) compound was prepared following general procedure D using 4-Amino-cyclohexanecarboxylic acid methyl ester (500 mg, 11.0 mmol), and Fmoc-isothiocyanate (730 mg). Purification: (Silica gel, ethyl acetate/hexane 1 :1). . LCMS m/z: 217.0 (M+1)+. /-MiiiΛiuic ui UiC αuuvc -r-u num σiuu-cyclohexanecarboxylic acid methyl ester (150 mg, 0.7 mmol) and 2-bromo-4'-isopropylacetophenone (100 mg, 0.4 mmol) in methanol (5 ml_) was heated at 6O0C for 2h. The reaction was concentrated and partitioned between Et2O and sodium bicarbonate (1:1). The organic phase was dried (MgSO4), filtered and concentrated under high vacuum. The crude residue was purified (Silica gel, ethyl acetate/hexane 5:95) to afford the ester (120 mg), which was hydrolyzed according to the general procedure T to give 4-[4-(4-lsopropyl-phenyl)-thiazol-2-ylamino]- cyclohexanecarboxylic acid (110 mg). LCMS m/z: 345 (M+1)+. Example 216 (S)-3-(3-Chloro-phenyl)-2-thioureido-propionic acid was prepared following general procedure D using (S)-2-amino-3-(3-chloro-phenyl)-propionic acid (399 mg, 2 mmol), Fmoc isothiocyanate (590 mg, 2 mmol) and DMF (6 ml_). The residue was combined with DCM (8 mL) and diethyl amine (2 mL). LCMS m/z: 259 (M+1)+. (S)-3-(3-Chloro-phenyl)-2-[4-(4-isopropyl-phenyl)-thiazol-2- ylamino]-propionic acid was prepared following general procedure B using 2-bromo-1-(4-isopropyl-phenyl)-ethanone (2 mmol), (S)-3-(3-chloro-phenyl)-2-thioureido-propionic acid and MeOH (10 mL). Purification by flash chromatography (ethyl acetate/hexanes 1:2, 1:1 , with 0:5% v/v acetic acid) gave the product (545 mg). LCMS m/z: 401 (M+1)+; 1H-NMR (400 MHz, CDCI3): 7.39- 7.45(m, 3H), 7.18-7.25(m, 5H), 6.37(s, 1H), 4.15(t, 1 H), 3.38(dd, 1H), 3.26(dd, 1H), 2.92(sept, 1 H), 1.27(d, 6H). Example 217 2,6-Dichloro-benzothiazole (160 mg, 0.784 mmoi), 3-cyclopentylamino-propionic acid tert-butyl ester (349 mg, 1.638 mmol), Pd2(dba)3 (55.0 mg, 0.06 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (71.1 mg, 0.123 mmol) and Cs2CO3 (670 mg, 2.055 mmol) were combined in dioxane (6 mL). The reaction mixture was heated to 850C (oil bath temperature) for 15 h. The reaction was cooled to room temperature and NH4CI (aq) was added. The product was extracted with EtOAc (4X15 mL), dried over MgSO4, filtered and concentrated. The residue was purified by silica gel chromatography (2% EtOAc-hexane) to furnish 66 mg of the product. The ester (66 mg) was charged with 4M HCI in dioxane (3 mL) and the reaction was stirred overnight at room temperature as indicated in general procedure G1 to afford the HCI salt of S-^δ-Chloro-benzothiazol^-yO-cyclopentyl-amino]- propionic acid (66 mg). LCMS m/z: 326. Example 218 5-{Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}- pentanoic acid (6.0 mg) was prepared following general method S2 using cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol- 2-yl]-amine (75mg, 0.27 mmol)(prepared in example 106), 5-bromopetanoic acid methyl ester (150 mg, 0.76 mmol) and NaH (40 mg, 60% in oil, 1.0 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following general procedure T. LCMS m/z: 387 Some of the compounds were prepared in multiple salt forms. For example, Examples 35, 41, 54, 62, 88, and 100 (all sodium salts) were also prepared as the corresponding HCI salt using general procedure G1 or G2. Example 37 appears as the HCI salt, however, the sodium salt was also prepared using general procedure J. Biological Assay The following methods are illustrative of the technique employed to measure the ability of the compounds of Formula (I) to functionally modulate the binding of AgRP to melanocortin receptors. The following example illustrates, in particular, the technique employed to measure the ability of compounds of Formula (I) to functionally modulate the binding of AgRP to MC-4R in the presence of a MC-4R agonist, such as alpha-MSH. Cell Culture and Maintenance HEK293 cells stably expressing human MC-4R receptors (See US Pat. No. 5,622,860 and related applications, herein incorporated by reference) were grown in high glucose Dulbecco's Modified Eagle Medium (DMEM) with 4500 mg glucose/L, L-glutamine, NaHCO3, pyrdoxin HCI, 10 mM HEPES (pH 7.4), 0.1 mM NEAA (non-essential amino acid mdeium) (GIBCO Cat#11140-050), 10% fetal bovine serum and 700 μg/mL G418. Cells were grown in T-225 flasks at 37°C with CO2 and humidity control. - Test Compound Treatment and cAMP Measurement On the day of assay, cells were washed twice with phosphate buffered saline without calcium and magnesium (PBS) and incubated with 10 ml_ PBS until the cells were detached from the flask. The detached cells were centrifuged at 240 g for 5 min. The cell pellet was re-suspended in assay buffer (Earle's balanced salt solution (Sigma E3024) supplemented with 10 mM HEPES1 pH 7.4, 1 mM MgCI2, 0.5 mM IBMX and protease inhibitor cocktail (Roche, 1 complete tablet/75 mL buffer)) containing anti-cAMP antibodies (Perkin Elmer FP cAMPfire kit FPA203002KT). Activity Assay The inhibitory or enhancement effect of compounds on AgRP activity was measured in a multi-component assay containing testing compounds, AgRP (human, Pheonix Pharma, cat no. 003-53), cells expressing MC-4R, and αMSH (Bachem, cat no. H-1075). Test; compounds, AgRP and αMSH were diluted with assay buffer. Test compounds and AgRP were mixed to 4 times of the final concentration and incubated at room. temperature for 30 min. Five μl_ of testing compound/AgRP solution followed with 10 μL of cells (20,000 cells/well) were added to each well of a 384-well reaction plate and pre-incubated for 15 min at 37°C before 5 μl_ ot αMbM was added. UeIIs were stimulated with αMSH for an additional 30 min at 37°C. Stimulation of cells was stopped and cells were lysed by adding 20 μl_ of detection buffer containing Alexa Fluor 594-cAMP (Perkin Elmer FP cAMPfire kit FPA203002KT) and incubation at room temperature for an hour. The intracellular cAMP concentration was measured using fluorescence polarization. Fluorescence polarization was measured using Envision (Perkin Elmer). Each data point was measured in triplicate and compiled as the mean of the three measurements ± the error of the mean of the three measurements. The data were fit with non-linear curve fitting algorithm using sigmoid curves in GraphPad Prism. Compounds of Formula (I) in Table 1 of the present invention inhibit the functional interaction of AgRP on MC-4R. The inhibition was shown by an increase in cAMP production and a reduction in fluorescence polarization in the assay. Such compounds posess an effective concentration for half maximal effect (EC50) in the assay of less than 15 μM. Control Assay 1 In a control experiment, the direct effect of the test compounds on cells (referred to as basal activity) was measured in the absence of AgRP and αMSH. Briefly, 10 μl of of testing compounds in assay buffer containing anti-cAMP antibodies and 10 μl of cells (20,000 cells/well) in the same buffer were added to each well of a 384-well reaction plate and incubated at 37°C for 30 min. The reaction was stopped by adding 20" μl detection buffer containing Alexa Fluor 594-cAMP. The fluorescence polarization reading was measured using Envision. Each data point was measured in triplicate and presented as the mean of the three measurements ± the error of the mean of the three measurements. The data were fit with non-linear curve fitting algorithm using sigmoid curves in GraphPad Prism. Compounds of the present invention showed minimal basal activity at MC-4R in this assay. Control Assay 2 The potentiating effect of test compounds on αMSH activity was also measured. Five μl_ of test article solution in assay buffer was mixed with 10 μL cells (20,000 cells/well) and incubated at 37°C for 15 min before 5 μL αMSH solution was added. Cells were stimulated with αMSH at 37°C for additional 30 min. The reaction was stopped by adding 20 μL detection buffer. The fluorescence polarization reading was measured using Envision. Each data point was measured in triplicate and presented as the mean of the three measurements ± the error of the mean of the three measurements. The data were fit with non-linear curve fitting algorithm using sigmoid curves in GraphPad Prism. Compounds of Formula (I) in Table 1 showed minimal effect on αMSH activity at the MC-4R in this assay. 13386

While the invention has been described and illustrated with reference to certain embodiments thereof, those skilled in the art will appreciate that various changes, modifications and substitutions can be made therein without departing from the spirit and scope of the invention. For example, effective dosages other than the dosages as set forth herein may be applicable as a consequence of variations in the responsiveness of the mammal being treated for melanocortin receptor - mediated disease(s). Likewise, the specific pharmacological responses observed may vary according to and depending on the particular active compound selected or whether there are present pharmaceutical carriers, as well as the type of formulation and mode of administration employed, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention.