Title:
SUBSTITUTED TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016521
Kind Code:
A1
Abstract:
Disclosed are a substituted triazole derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof; specifically, provided are a compound represented by general formula (I), cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, or pharmaceutically acceptable salts or prodrugs thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as an α5-GABAA receptor inverse modulator.
Inventors:
LIU YANG (CN)
JIN YUN (CN)
YANG FEI (CN)
WANG FEI (CN)
JIN YUN (CN)
YANG FEI (CN)
WANG FEI (CN)
Application Number:
PCT/CN2022/111829
Publication Date:
February 16, 2023
Filing Date:
August 11, 2022
Export Citation:
Assignee:
SHANGHAI SIMR BIOTECHNOLOGY CO LTD (CN)
SHANGHAI SIMRD BIOTECHNOLOGY CO LTD (CN)
SHANGHAI SIMRD BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D403/14; A61K31/501; A61P25/00; C07D401/14; C07D413/14
Domestic Patent References:
| WO2014001279A1 | 2014-01-03 | |||
| WO2014001280A1 | 2014-01-03 | |||
| WO1992022652A1 | 1992-12-23 | |||
| WO1994013799A1 | 1994-06-23 |
Foreign References:
| CN112424197A | 2021-02-26 | |||
| CN104411699A | 2015-03-11 | |||
| CN111138417A | 2020-05-12 | |||
| CN107108595A | 2017-08-29 | |||
| CN202110927008A | 2021-08-12 | |||
| US20110224278A1 | 2011-09-15 | |||
| CN103239720A | 2013-08-14 |
Other References:
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WAFFORD, K. A.WHITING, P. J.KEMP, J. A., MOL. PHARMACOL., vol. 43, 1993, pages 240 - 244
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"Design of Prodrug", 1985, ELSEVIER
BONICA ET AL.: "The Management of Pain", vol. 1, 1990, LEAS & FEBOGER
FARRANT, M. ET AL., NAT REV NEUROSCI, vol. 6, 2005, pages 215 - 229
YEUNG JY ET AL., MOL PHARMACOL, vol. 63, 2003, pages 2 - 8
LEE, K. Y. ET AL., NEUROSCIENCE, vol. 208, 2012, pages 133 - 142
I. LECKERY YIND. S. WANGB. A. ORSER, BRITISH JOURNAL OF ANAESTHESIA, vol. 110, no. S1, 2013, pages 73 - 81
"GenBank", Database accession no. NM_000816.3
DRUG METABOLISM AND DISPOSITION, vol. 36, no. 2, 2008, pages 268 - 275
XIAO HS ET AL., PROC NATL ACAD SCI USA., vol. 99, no. 12, 2002, pages 8360 - 8365
GOEDERS, N. E.KUHAR, M. J., LIFE SCI., vol. 37, no. 4, 1985, pages 345 - 355
WAFFORD, K. A.WHITING, P. J.KEMP, J. A., MOL. PHARMACOL., vol. 43, 1993, pages 240 - 244
JONES ET AL., BIOORGMED CHEM LETT., vol. 16, no. 4, 2006, pages 872 - 875
BRICKLEY, S.G.MODY, I., NEURON., vol. 73, 2012, pages 23 - 34
HARRIS, D. ET AL., J. MED. CHEM., vol. 51, 2008, pages 3788 - 3803
SAVIC, M. M. ET AL., BRAIN RES., vol. 1208, 2008, pages 150 - 159
CLEMENT, Y ET AL., BEHAV. BRAIN RES., vol. 233, 2012, pages 474 - 482
HELDT, S. A.RESSLER, K. J., EUR. J. NEUROSCI., vol. 26, 2007, pages 3631 - 3644
TASAN, R.O. ET AL., NEUROSCIENCE, vol. 183, 2011, pages 71 - 80
"Design of Prodrug", 1985, ELSEVIER
BONICA ET AL.: "The Management of Pain", vol. 1, 1990, LEAS & FEBOGER
FARRANT, M. ET AL., NAT REV NEUROSCI, vol. 6, 2005, pages 215 - 229
YEUNG JY ET AL., MOL PHARMACOL, vol. 63, 2003, pages 2 - 8
LEE, K. Y. ET AL., NEUROSCIENCE, vol. 208, 2012, pages 133 - 142
I. LECKERY YIND. S. WANGB. A. ORSER, BRITISH JOURNAL OF ANAESTHESIA, vol. 110, no. S1, 2013, pages 73 - 81
"GenBank", Database accession no. NM_000816.3
DRUG METABOLISM AND DISPOSITION, vol. 36, no. 2, 2008, pages 268 - 275
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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