Title:
SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169226
Kind Code:
A1
Abstract:
Provided are substituted tricyclic compounds as PARP inhibitors and the use thereof. The compounds represented by Formula (I) as below, wherein, the ring Z, Z1, Z2, Z3, Z4, Z5, A1, A2, A3, L and Cy are defined herein. The compounds of Formula I are PARP inhibitors and thus are useful in the treatment of diseases, disorders and conditions, such as cancer, responsive to the inhibition of PARP activity.
Inventors:
CAI SUI XIONG (CN)
TIAN YE EDWARD (CN)
WANG XIAOZHU (CN)
ZHANG LETIAN (CN)
TIAN YE EDWARD (CN)
WANG XIAOZHU (CN)
ZHANG LETIAN (CN)
Application Number:
PCT/CN2023/077988
Publication Date:
September 14, 2023
Filing Date:
February 23, 2023
Export Citation:
Assignee:
IMPACT THERAPEUTICS SHANGHAI INC (CN)
International Classes:
C07D491/048; A61K31/496; A61P35/00; A61P35/02; C07D471/00; C07D491/147; C07D495/04
Domestic Patent References:
| WO2022225934A1 | 2022-10-27 |
Foreign References:
| CN102341394A | 2012-02-01 | |||
| US20120129868A1 | 2012-05-24 | |||
| US20050171101A1 | 2005-08-04 | |||
| CN101528704A | 2009-09-09 | |||
| CN107849040A | 2018-03-27 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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