Title:
SUBSTRATE FOR MASS SPECTROMETRIC ANALYSIS, PROCESS FOR PRODUCING SAME, AND MASS SPECTROMETRY
Document Type and Number:
WIPO Patent Application WO/2011/004889
Kind Code:
A1
Abstract:
A substrate for mass spectrometric analysis is provided with which it is possible to further advance the performance of a matrix-free ionization method and to conduct analysis by laser desorption ionization-mass spectrometry without requiring the use of an ionizing agent which can be causative of noise or a decrease in detection sensitivity. Also provided is a process for producing the substrate. The substrate for mass spectrometric analysis comprises a base equipped thereon with a metal oxide to which an organic substance capable of supplying protons and/or cations is adherent. The process for producing the substrate for mass spectrometric analysis comprises: coating a base with a metal oxide dispersion obtained by dispersing a metal oxide with the aid of an organic substance capable of supplying protons and/or cations; and drying the coating.
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Inventors:
KAWASAKI HIDEYA (JP)
ARAKAWA RYUICHI (JP)
MIZOGUCHI DAIGOU (JP)
MUROUCHI MASATO (JP)
TAMURA YUSUKE (JP)
ARAKAWA RYUICHI (JP)
MIZOGUCHI DAIGOU (JP)
MUROUCHI MASATO (JP)
TAMURA YUSUKE (JP)
Application Number:
PCT/JP2010/061684
Publication Date:
January 13, 2011
Filing Date:
July 09, 2010
Export Citation:
Assignee:
DAINIPPON TORYO KK (JP)
KAWASAKI HIDEYA (JP)
ARAKAWA RYUICHI (JP)
MIZOGUCHI DAIGOU (JP)
MUROUCHI MASATO (JP)
TAMURA YUSUKE (JP)
KAWASAKI HIDEYA (JP)
ARAKAWA RYUICHI (JP)
MIZOGUCHI DAIGOU (JP)
MUROUCHI MASATO (JP)
TAMURA YUSUKE (JP)
International Classes:
G01N27/64; G01N27/62; H01J49/04; H01J49/14
Foreign References:
| JPS62284256A | 1987-12-10 | |||
| JP2008204654A | 2008-09-04 | |||
| JP2010151727A | 2010-07-08 |
Other References:
CHIU YU-CHIH ET AL.: "Carbocylate- Functionalized Iron Oxide Nanoparticles in Surface-Assisted Laser", ANAL LETT, vol. 41, no. 1/3, 1 January 2008 (2008-01-01), pages 260 - 267, XP008093611, DOI: doi:10.1080/00032710701792653
"The 55th Annual Conference on Mass Spectrometry (2007) Koen Yoshishu, 01 May 2007 (01.05.2007)", article LEE.C.CHEN ET AL.: "Visible Laser Desorption/ Ionization Mass Spectrometry Using Metallic Nanostructure", pages: 66 - 67
"Abstracts of the Meeting of the Physical Society of Japan, vol.62, no.2 (Dai 62 Kai Nenji Taikai) separate vol.3, 2007", article SHINJI MORITAKE ET AL.: "Development of Magnetic Nanoparticles with Ability of Assisting Ionization", pages: 473
WEI-YU CHEN ET AL.: "Affinitiy-based mass spectrometry using magnetic iron oxide particles as the matrix and concentrating probes for SALDI MS analysis of peptides and proteins", ANAL BIOANAL CHEM, vol. 386, no. 3, 2006, pages 699 - 704, XP019441075, DOI: doi:10.1007/s00216-006-0427-0
"The 61th Divisional Meeting on Colloid and Interface Chemistry Koen Yoshishu, page 267, 20 August 2008 (20.08.2008)", article HIDEYA KAWASAKI ET AL.: "Hyomen Shien Laser Datsuri Ion-ka Shitsuryo Bunsekiho (SALDI-MS) no Tame Kin Nano-Ryushi/Kobunshi Kogo Kyuchaku Silicon Kiban"
YONEZAWA TETSU ET AL.: "Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry", ANA SCI, vol. 25, no. 3, March 2009 (2009-03-01), pages 339 - 346
"The 55th Annual Conference on Mass Spectrometry (2007) Koen Yoshishu, 01 May 2007 (01.05.2007)", article LEE.C.CHEN ET AL.: "Visible Laser Desorption/ Ionization Mass Spectrometry Using Metallic Nanostructure", pages: 66 - 67
"Abstracts of the Meeting of the Physical Society of Japan, vol.62, no.2 (Dai 62 Kai Nenji Taikai) separate vol.3, 2007", article SHINJI MORITAKE ET AL.: "Development of Magnetic Nanoparticles with Ability of Assisting Ionization", pages: 473
WEI-YU CHEN ET AL.: "Affinitiy-based mass spectrometry using magnetic iron oxide particles as the matrix and concentrating probes for SALDI MS analysis of peptides and proteins", ANAL BIOANAL CHEM, vol. 386, no. 3, 2006, pages 699 - 704, XP019441075, DOI: doi:10.1007/s00216-006-0427-0
"The 61th Divisional Meeting on Colloid and Interface Chemistry Koen Yoshishu, page 267, 20 August 2008 (20.08.2008)", article HIDEYA KAWASAKI ET AL.: "Hyomen Shien Laser Datsuri Ion-ka Shitsuryo Bunsekiho (SALDI-MS) no Tame Kin Nano-Ryushi/Kobunshi Kogo Kyuchaku Silicon Kiban"
YONEZAWA TETSU ET AL.: "Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry", ANA SCI, vol. 25, no. 3, March 2009 (2009-03-01), pages 339 - 346
Attorney, Agent or Firm:
SASAKI Kazuya et al. (JP)
Kazuya Sasaki (JP)
Kazuya Sasaki (JP)
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