Title:
SULFAMYL-CONTAINING 1,2,5-OXADIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO/2016/155545
Kind Code:
A1
Abstract:
Disclosed are a sulfamyl-containing 1,2,5-oxadiazole derivative, a preparation method therefor, and a use thereof in pharmaceuticals. Specifically disclosed are a sulfamyl-containing 1,2,5-oxadiazole derivative of generic formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and use thereof as an IDO (Indoleamine-pyrrole-2,3-dioxygenase) inhibitor, and the sulfamyl-containing 1,2,5-oxadiazole derivative can be applied to treating diseases having IDO-mediated tryptophan metabolic pathway pathological features, including tumors, cancers, Alzheimer's Disease, autoimmune diseases, depression, anxiety disorder, cataract, psychological disorder and AIDS. Wherein various substituents in generic formula (I) have the same meanings as defined in the description.
Inventors:
LV HEJUN (CN)
GUI BIN (CN)
DONG QING (CN)
GUI BIN (CN)
DONG QING (CN)
Application Number:
PCT/CN2016/076975
Publication Date:
October 06, 2016
Filing Date:
March 22, 2016
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D271/08; A61K31/4245; A61P25/28; A61P35/00; A61P35/02; A61P37/00
Domestic Patent References:
| WO2008058178A1 | 2008-05-15 |
Foreign References:
| CN102164902A | 2011-08-24 | |||
| US20070185165A1 | 2007-08-09 |
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
北京戈程知识产权代理有限公司 (CN)
北京戈程知识产权代理有限公司 (CN)
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