SULFATED CCR5 PEPTIDES FOR HIV-1 INFECTION

Title:

SULFATED CCR5 PEPTIDES FOR HIV-1 INFECTION

Document Type and Number:

WIPO Patent Application WO2001064710

Kind Code:

A8

Abstract:

This invention provides a compound comprising the structure: thetaalphaYDINYYTSEbetalambda wherein each T represents a threonine, each S represents a serine, each E represents a glutamic acid, each Y represents a tyrosine; each D represents an aspartic acid, each I represents an isoleucine; and each N represents an asparagine; wherein alpha represents from 0 to 9 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the I at position 9 and extending therefrom in the amino terminal direction; wherein beta represents from 0 to 13 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the P at position 19 and extending therefrom in the carboxy terminal direction; wherein theta represents an amino group or an acetylated amino group; wherein lambda represents a carboxyl group or an amidated carboxyl group; wherein all of alpha,Y,D,I,N,Y,Y,T,S,E and beta are joined together by peptide bonds; further provided that at least two tyrosines in the compound are sulfated.

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Inventors:

DRAGIC TATJANA (US)
OLSON WILLIAM C (US)

Application Number:

PCT/US2001/006699

Publication Date:

December 31, 2003

Filing Date:

February 28, 2001

Export Citation:

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Assignee:

PROGENICS PHARM INC (US)
AARON DIAMOND AIDS RES CT (US)
DRAGIC TATJANA (US)
OLSON WILLIAM C (US)

International Classes:

C07K14/715; C07K16/28; A61K38/00; (IPC1-7): A61K39/00; C07K7/00; C07K7/06; C07K7/08; G01N33/53; G01N33/566

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