Title:
SULFONAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/133160
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel low molecular weight compound that exhibits orexin receptor agonist activity and is expected to be useful as an excellent preventative or therapeutic agent for narcolepsy or the like. The present invention provides a sulfonamide derivative represented by general formula (I) that has excellent orexin receptor agonist activity (wherein each symbol has the same definition as that described in the specification) and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin receptor agonist comprising the derivative or the pharmaceutically acceptable acid addition salt thereof.
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Inventors:
YANAGISAWA MASASHI (JP)
NAGASE HIROSHI (JP)
SAITOH TSUYOSHI (JP)
IRUKAYAMA YOKO (JP)
NAGASE HIROSHI (JP)
SAITOH TSUYOSHI (JP)
IRUKAYAMA YOKO (JP)
Application Number:
PCT/JP2016/054700
Publication Date:
August 25, 2016
Filing Date:
February 18, 2016
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
UNIV TEXAS (US)
UNIV TEXAS (US)
International Classes:
C07C311/29; A61K31/18; A61K31/341; A61K31/36; A61K31/405; A61K31/426; A61K31/4406; A61K31/4439; A61K31/47; A61K31/472; A61K31/498; A61P3/04; A61P3/10; A61P25/24; A61P25/26; A61P31/04; A61P43/00; C07D209/20; C07D213/40; C07D215/48; C07D215/50; C07D217/26; C07D241/44; C07D277/56; C07D307/54; C07D317/56; C07D417/04
Domestic Patent References:
| WO2007019234A2 | 2007-02-15 | |||
| WO2004033418A2 | 2004-04-22 | |||
| WO2010014794A1 | 2010-02-04 | |||
| WO2007118852A1 | 2007-10-25 | |||
| WO2009092642A1 | 2009-07-30 | |||
| WO2010051237A1 | 2010-05-06 | |||
| WO2015088000A1 | 2015-06-18 |
Foreign References:
| US6153585A | 2000-11-28 | |||
| US20100150840A1 | 2010-06-17 |
Other References:
NAGAHARA,T. ET AL.: "Design and synthesis of non- peptide, selective orexin receptor 2 agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 2015, pages 7931 - 7937
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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