Title:
SULFONAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALT
Document Type and Number:
WIPO Patent Application WO/2019/117148
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel low molecular-weight compound having orexin receptor agonist activity that is expected to be useful for the prevention or treatment of narcolepsy, etc. The present invention provides: a compound represented by formula (I) that has orexin receptor agonist activity (the symbols in the formula are the same as defined in the description) or a pharmaceutically acceptable acid-addition salt thereof; and an orexin receptor agonist comprising the compound or pharmaceutically acceptable acid-addition salt thereof.
Inventors:
NAGASE HIROSHI (JP)
SAITOH TSUYOSHI (JP)
YANAGISAWA MASASHI (JP)
IRUKAYAMA YOKO (JP)
SAITOH TSUYOSHI (JP)
YANAGISAWA MASASHI (JP)
IRUKAYAMA YOKO (JP)
Application Number:
PCT/JP2018/045523
Publication Date:
June 20, 2019
Filing Date:
December 11, 2018
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
UNIV TEXAS (US)
UNIV TEXAS (US)
International Classes:
C07D239/10; A61K31/513; A61P3/04; A61P3/10; A61P9/00; A61P21/00; A61P25/00; A61P25/08; A61P25/18; A61P25/24; A61P25/26; A61P43/00; C07D403/12
Domestic Patent References:
| WO2016199906A1 | 2016-12-15 | |||
| WO2015088000A1 | 2015-06-18 | |||
| WO2016133160A1 | 2016-08-25 | |||
| WO2015152367A1 | 2015-10-08 |
Foreign References:
| JP2002536447A | 2002-10-29 | |||
| JP2015521999A | 2015-08-03 | |||
| US8258163B2 | 2012-09-04 | |||
| JP2017238093A | 2017-12-12 |
Other References:
MORENO, ANTONIO ET AL.: "Synthesis and evaluation of new [(arylsulfonamido)methyl]cyclohexyl derivatives as human neuropeptide Y Y5 receptor antagonists for the treatment of obesity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 1, 2004, pages 49 - 58, XP055617715, DOI: 10.1016/j.ejmech.2003.10.001
PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 322 - 327
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
NEURON, vol. 38, 2003, pages 701 - 713
ARCH. NEUROL., vol. 59, 2002, pages 1553 - 1562
CELL METAB., vol. 9, 2009, pages 64 - 76
J. NEUROSCI., vol. 31, no. 31, 2011, pages 11376 - 11386
CRIT. CARE MED., vol. 41, 2013, pages 1 - 8
"Fieser and Fieser's Reagent for Organic Synthesis", WILEY&SONS
See also references of EP 3725780A4
PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 322 - 327
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
NEURON, vol. 38, 2003, pages 701 - 713
ARCH. NEUROL., vol. 59, 2002, pages 1553 - 1562
CELL METAB., vol. 9, 2009, pages 64 - 76
J. NEUROSCI., vol. 31, no. 31, 2011, pages 11376 - 11386
CRIT. CARE MED., vol. 41, 2013, pages 1 - 8
"Fieser and Fieser's Reagent for Organic Synthesis", WILEY&SONS
See also references of EP 3725780A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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