SULFONAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF

Title:

SULFONAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF

Document Type and Number:

WIPO Patent Application WO/1999/040075

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) or salts thereof and prodrugs of the same which have an inhibitory effect on activated blood coagulation factor X and thus are useful as anticoagulating agents. In formula (I), R?1¿ represents a hydrocarbyl or heterocyclic group each optionally substituted; the ring A represents a divalent nitrogen-containing heterocycle group optionally further substituted; X' represents optionally substituted alkylene; Y represents an optionally substituted divalent cyclic group; X represents a bond or optionally substituted alkylene; and Z represents (1) optionally substituted amino, (2) optionally substituted imidoyl, or (3) an optionally substituted nitrogen-containing heterocyclic group.

Inventors:

TAWADA HIROYUKI (JP)
ITOH FUMIO (JP)
BANNO HIROSHI (JP)
TERASHITA ZEN-ICHI (JP)

Application Number:

PCT/JP1999/000470

Publication Date:

August 12, 1999

Filing Date:

February 04, 1999

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
TAWADA HIROYUKI (JP)
ITOH FUMIO (JP)
BANNO HIROSHI (JP)
TERASHITA ZEN ICHI (JP)

International Classes:

C07D241/08; C07D243/08; C07D401/06; C07D401/12; C07D401/14; C07D403/08; C07D403/10; C07D403/12; C07D405/14; C07D409/06; C07D409/14; C07D413/12; C07D521/00; (IPC1-7): C07D241/08; A61K31/495; C07D401/12; C07D401/14; C07D403/12; C07D403/10; C07D405/12; C07D405/14; C07D409/10; C07D409/12

Domestic Patent References:

WO1999006395A1	1999-02-11
WO1998021188A1	1998-05-22
WO1996033982A1	1996-10-31
WO1996016947A1	1996-06-06

Foreign References:

JPS49110680A	1974-10-22
JPH0625285A	1994-02-01

Other References: