Title:
SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO1999002502
Kind Code:
A3
Abstract:
The invention relates to novel compounds of formula (I) or a salt thereof having pharmacological activity (5-HT6 receptor antagonists), process for their preparation, to compositions containing them and to their use in the treatment of CNS disorders.
Inventors:
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERIK (GB)
MOSS STEPHEN FREDERIK (GB)
Application Number:
PCT/EP1998/004973
Publication Date:
June 03, 1999
Filing Date:
July 09, 1998
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERIK (GB)
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERIK (GB)
International Classes:
A61K31/426; A61K31/44; A61K31/495; C07D295/08; A61K31/496; A61P25/22; A61P25/24; C07D207/325; C07D209/02; C07D209/08; C07D209/44; C07D213/40; C07D213/61; C07D215/12; C07D215/38; C07D215/58; C07D217/08; C07D217/22; C07D263/32; C07D277/20; C07D277/46; C07D277/52; C07D295/096; C07D307/79; C07D307/82; C07D307/91; C07D317/66; C07D401/04; C07D487/04; C07D207/32; (IPC1-7): C07D295/135; C07D401/12; A61K31/495
Domestic Patent References:
| WO1998027081A1 | 1998-06-25 | |||
| WO1998027058A2 | 1998-06-25 | |||
| WO1997029097A1 | 1997-08-14 | |||
| WO1995004729A1 | 1995-02-16 | |||
| WO1995015954A1 | 1995-06-15 | |||
| WO1997014689A1 | 1997-04-24 | |||
| WO1997007120A1 | 1997-02-27 |
Foreign References:
| EP0815861A1 | 1998-01-07 | |||
| DE2442851A1 | 1976-03-18 |
Other References:
MONSMA,F.P. ET AL.: "Cloning and Expression of A Novel Serotonin Receptor with High Affinity for Tricyclic Psychotropic Drugs", MOL.PHARMACOL., vol. 43, no. 3, 1993, BALTIMORE, pages 320 - 327, XP002093842
HOYER,D. AND MARTIN,G.: "5-HT receptor classification and nomenclature: towards a harmonization with the human genome", NEUROPHARMACOLOGY, no. 36, April 1997 (1997-04-01), pages 419 - 428, XP002075372
SAUDOU F ET AL: "5-HT RECEPTOR SUBTYPES: MOLECULAR AND FUNCTIONAL DIVERSITY", MEDICINAL CHEMISTRY RESEARCH, vol. 4, no. 1, 1994, pages 16 - 84, XP000604196
BOND R A ET AL: "Romancing receptor research at Verona classification meeting", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 17, no. 3, March 1996 (1996-03-01), pages 85-89, XP004034526
EGLEN R M ET AL: "The 5-HT7 receptor: orphan found", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 18, no. 4, April 1997 (1997-04-01), pages 104-107, XP004058670
JORAND-LEBRUN C ET AL: "Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 24, 16 December 1997 (1997-12-16), pages 3183-3188, XP004136608
MARTIN G R ET AL: "The structure and signalling properties of 5-HT receptors: an endless diversity?", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 19, no. 1, 1 January 1998 (1998-01-01), pages 2-4, XP004107578
SLEIGHT,A.J. ET AL.: "The 5-hydroxytryptamine-6 receptor : localisation and function", EXP.OPIN.THER.PATENTS, vol. 8, no. 10, October 1998 (1998-10-01), LONDON, pages 1217 - 1224, XP002093843
HOYER,D. AND MARTIN,G.: "5-HT receptor classification and nomenclature: towards a harmonization with the human genome", NEUROPHARMACOLOGY, no. 36, April 1997 (1997-04-01), pages 419 - 428, XP002075372
SAUDOU F ET AL: "5-HT RECEPTOR SUBTYPES: MOLECULAR AND FUNCTIONAL DIVERSITY", MEDICINAL CHEMISTRY RESEARCH, vol. 4, no. 1, 1994, pages 16 - 84, XP000604196
BOND R A ET AL: "Romancing receptor research at Verona classification meeting", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 17, no. 3, March 1996 (1996-03-01), pages 85-89, XP004034526
EGLEN R M ET AL: "The 5-HT7 receptor: orphan found", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 18, no. 4, April 1997 (1997-04-01), pages 104-107, XP004058670
JORAND-LEBRUN C ET AL: "Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 24, 16 December 1997 (1997-12-16), pages 3183-3188, XP004136608
MARTIN G R ET AL: "The structure and signalling properties of 5-HT receptors: an endless diversity?", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 19, no. 1, 1 January 1998 (1998-01-01), pages 2-4, XP004107578
SLEIGHT,A.J. ET AL.: "The 5-hydroxytryptamine-6 receptor : localisation and function", EXP.OPIN.THER.PATENTS, vol. 8, no. 10, October 1998 (1998-10-01), LONDON, pages 1217 - 1224, XP002093843
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