Title:
SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO1999037623
Kind Code:
A3
Abstract:
The invention relates to novel compounds of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C). Compounds of formula (I) and their pharmaceutically acceptable salts have 5HT6 receptor antagonist activity and are believed to be of potential use in the treatment of certain CNS disorders such as anxiety, depression, epilespy, obsessive compulsive disorders, migraine, cognitive memory disorders e.g. Alzheimers disease, Parkinson' Disease, ADHD (Attention Deficit Disorder/Hyperactivity Syndrome), sleep disorders (including disturbances of Circadian rhythym), feeding disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia, and also disorders associated with spinal trauma and/or head injury such as hydrocephalus. Compounds of the invention are also expected to be of use in the treatment of certain GI (gastrointestinal) disorders such as IBS (Irritable Bowel Syndrome).
Inventors:
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERICK (GB)
MOSS STEPHEN FREDERICK (GB)
Application Number:
PCT/EP1999/000262
Publication Date:
October 21, 1999
Filing Date:
January 13, 1999
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERICK (GB)
BROMIDGE STEVEN MARK (GB)
MOSS STEPHEN FREDERICK (GB)
International Classes:
C07D295/08; A61K31/495; A61K31/496; A61P1/14; A61P3/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; C07D211/96; C07D215/58; C07D217/08; C07D295/096; C07D295/22; (IPC1-7): C07D295/096; A61K31/495; A61K31/50; C07D215/58; C07D217/08
Foreign References:
| EP0244115A2 | 1987-11-04 | |||
| DE3411993A1 | 1985-10-10 | |||
| EP0103464A2 | 1984-03-21 | |||
| US3635982A | 1972-01-18 | |||
| BE620236R | 1963-01-14 | |||
| EP0675118A2 | 1995-10-04 | |||
| EP0815861A1 | 1998-01-07 |
Other References:
G. RÉGNIER ET AL.: "Etude chimique et pharmacologique de nouveaux dérivés de la nor-adrenaline", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH., vol. 19, no. 10, - 1969, EDITIO CANTOR. AULENDORF., DE, pages 1698 - 1702, XP002112727, ISSN: 0004-4172
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