Title:
SUPERMERE NANOPARTICLES AND METHODS OF ISOLATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/060066
Kind Code:
A3
Abstract:
Disclosed herein is a newly identified secreted nanoparticle that is morphologically and molecularly distinct from the recently described nanoparticle termed an exomere. The disclosed nanoparticle is referred to herein as a supermere. Both exomeres and supermeres are amembranous in contrast to membrane-enclosed extracellular vesicles (EVs). Supermeres are smaller and morphologically distinct from exomeres. These supermeres contain cargo with diagnostic and therapeutic applications.
Inventors:
COFFEY ROBERT J (US)
FRANKLIN JEFFREY (US)
JEPPESEN DENNIS (US)
HIGGINBOTHAM JAMES N (US)
ZHANG QIN (US)
FRANKLIN JEFFREY (US)
JEPPESEN DENNIS (US)
HIGGINBOTHAM JAMES N (US)
ZHANG QIN (US)
Application Number:
PCT/US2022/077513
Publication Date:
October 19, 2023
Filing Date:
October 04, 2022
Export Citation:
Assignee:
UNIV VANDERBILT (US)
International Classes:
B01D21/26; A61K9/10; A61K39/215; G01N33/68; G01N33/50
Domestic Patent References:
| WO2023060066A2 | 2023-04-13 |
Foreign References:
| US20210285952A1 | 2021-09-16 | |||
| US20210260201A1 | 2021-08-26 |
Other References:
ZHANG HAIYING; FREITAS DANIELA; KIM HAN SANG; FABIJANIC KRISTINA; LI ZHONG; CHEN HAIYAN; MARK MILICA TESIC; MOLINA HENRIK; MARTIN : "Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation", NATURE CELL BIOLOGY, vol. 20, no. 3, 19 February 2018 (2018-02-19), London, pages 332 - 343, XP036709197, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0040-4
ZHANG QIN, HIGGINBOTHAM JAMES N., JEPPESEN DENNIS K., YANG YU-PING, LI WEI, MCKINLEY ELIOT T., GRAVES-DEAL RAMONA, PING JIE, BRITA: "Transfer of Functional Cargo in Exomeres", CELL REPORTS, vol. 27, no. 3, 1 April 2019 (2019-04-01), US , pages 940 - 954., XP093102711, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.01.009
ZHANG QIN; JEPPESEN DENNIS K.; HIGGINBOTHAM JAMES N.; GRAVES-DEAL RAMONA; TRINH VINCENT Q.; RAMIREZ MARISOL A.; SOHN YOOJIN; NEINI: "Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets", NATURE CELL BIOLOGY, vol. 23, no. 12, 1 December 2021 (2021-12-01), London, pages 1240 - 1254, XP037646087, ISSN: 1465-7392, DOI: 10.1038/s41556-021-00805-8
ZHANG QIN, HIGGINBOTHAM JAMES N., JEPPESEN DENNIS K., YANG YU-PING, LI WEI, MCKINLEY ELIOT T., GRAVES-DEAL RAMONA, PING JIE, BRITA: "Transfer of Functional Cargo in Exomeres", CELL REPORTS, vol. 27, no. 3, 1 April 2019 (2019-04-01), US , pages 940 - 954., XP093102711, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.01.009
ZHANG QIN; JEPPESEN DENNIS K.; HIGGINBOTHAM JAMES N.; GRAVES-DEAL RAMONA; TRINH VINCENT Q.; RAMIREZ MARISOL A.; SOHN YOOJIN; NEINI: "Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets", NATURE CELL BIOLOGY, vol. 23, no. 12, 1 December 2021 (2021-12-01), London, pages 1240 - 1254, XP037646087, ISSN: 1465-7392, DOI: 10.1038/s41556-021-00805-8
Attorney, Agent or Firm:
GILES, P. Brian (US)
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