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Title:
SUPPRESSION OF CANCERS
Document Type and Number:
WIPO Patent Application WO/2009/150470
Kind Code:
A3
Abstract:
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/ or lung cancer. The therapy employs use of anon-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell.When so delivered, the protease is internalised and inhibits secretion/ transmission of growth hormonefromsaid cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

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Inventors:
MADEC FREDERIC (GB)
LECANE PHIL (GB)
MARKS PHILIP (GB)
FOSTER KEITH (GB)
Application Number:
PCT/GB2009/050666
Publication Date:
July 15, 2010
Filing Date:
June 11, 2009
Export Citation:
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Assignee:
SYNTAXIN LTD (GB)
MADEC FREDERIC (GB)
LECANE PHIL (GB)
MARKS PHILIP (GB)
FOSTER KEITH (GB)
International Classes:
A61K38/00; C12N9/00; A61P35/00
Domestic Patent References:
WO2006026780A12006-03-09
WO2006099590A22006-09-21
WO2004076634A22004-09-10
WO2006025976A12006-03-09
WO2005016953A22005-02-24
WO1997042223A11997-11-13
Foreign References:
US20050031648A12005-02-10
Other References:
JACOBSSON G, HÅKANSSON ML, HULTING AL, MEISTER B.: "Botulinum neurotoxin F, a VAMP-specific endopeptidase, inhibits Ca(2+)-stimulated GH secretion from rat pituitary cells", REGUL PEPT, vol. 71, no. 1, 23 July 1997 (1997-07-23), XP002581489
SCHALLY ANDREW V ET AL: "Antagonists of growth hormone-releasing hormone in oncology", CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD, NETHERLANDS, vol. 9, no. 3, 1 March 2006 (2006-03-01), pages 163 - 170, XP009120779, ISSN: 1568-0266
Attorney, Agent or Firm:
MACLEAN, Martin et al. (London, Greater London EC1N 2SQ, GB)
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