Title:
SUPPRESSION OF XENOTRANSPLANT REJECTION
Document Type and Number:
WIPO Patent Application WO2000031126
Kind Code:
A3
Abstract:
The invention relates to the suppression of graft rejection, particularly to the suppression of xenograft rejection. In particular, the invention relates to biological tissues that contain endothelial cells that may be induced to generate a compound which down-regulates the expression of a cell adhesion molecule in these cells.
Inventors:
RAMRAKHA PUNIT SATYAVRAT (GB)
GEORGE ANDREW JOHN TIMOTHY (GB)
HASKARD DORIAN (GB)
LECHLER ROBERT IAN (GB)
GEORGE ANDREW JOHN TIMOTHY (GB)
HASKARD DORIAN (GB)
LECHLER ROBERT IAN (GB)
Application Number:
PCT/GB1999/003888
Publication Date:
August 24, 2000
Filing Date:
November 22, 1999
Export Citation:
Assignee:
IMP COLLEGE INNOVATIONS LTD (GB)
RAMRAKHA PUNIT SATYAVRAT (GB)
GEORGE ANDREW JOHN TIMOTHY (GB)
HASKARD DORIAN (GB)
LECHLER ROBERT IAN (GB)
RAMRAKHA PUNIT SATYAVRAT (GB)
GEORGE ANDREW JOHN TIMOTHY (GB)
HASKARD DORIAN (GB)
LECHLER ROBERT IAN (GB)
International Classes:
A61L27/00; C07K14/47; C07K16/28; A01K67/027; C07K19/00; C12N5/07; C12N5/078; C12N5/10; C12N15/09; C12N15/113; A61K35/12; A61K48/00; (IPC1-7): C12N5/10; C07K16/46; C12N15/62; A01K67/027; C12N15/00
Domestic Patent References:
| WO1996015780A1 | 1996-05-30 | |||
| WO1997011971A1 | 1997-04-03 |
Other References:
DORLING ANTHONY ET AL: "In vitro accommodation of immortalized porcine endothelial cells: Resistance to complement mediated lysis and down-regulation of VCAM expression induced by low concentrations of polyclonal human IgG antipig antibodies.", TRANSPLANTATION (BALTIMORE) 1996, vol. 62, no. 8, 1996, pages 1127 - 1136, XP000909707, ISSN: 0041-1337
GERRITSEN M E ET AL: "FLAVENOIDS INHIBIT CYTOKINE-INDUCED ENDOTHELIAL CELL ADHESION PROTEIN GENE EXPRESSION", AMERICAN JOURNAL OF PATHOLOGY,US,PHILADELPHIA, PA, vol. 147, no. 2, 1 August 1995 (1995-08-01), pages 278 - 292, XP000575649, ISSN: 0002-9440
ELICES M J ET AL: "VCAM-1 ON ACTIVATED ENDOTHELIUM INTERACTS WITH THE LEUKOCYTE INTEGRIN VLA-4 AT A SITE DISTINCT FROM THE VLA-4/FIBRONECTIN BINDING SITE", CELL,US,CELL PRESS, CAMBRIDGE, NA, vol. 60, 23 February 1990 (1990-02-23), pages 577 - 584, XP000606922, ISSN: 0092-8674
ROBINSON L A ET AL: "The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation.", JOURNAL OF IMMUNOLOGY, (1998 DEC 15) 161 (12) 6931-8., XP000887398
HAMMER C ET AL: "Organs from animals for man.", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY MAY, 1998, vol. 116, no. 1, May 1998 (1998-05-01), pages 5 - 21, XP000909785, ISSN: 1018-2438
ISOBE M ET AL: "SPECIFIC ACCEPTANCE OF CARDIAC ALLOGRAFT AFTER TREATMENT WITH ANTIBODIES TO ICAM-1 AND LFA1", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 255, 28 February 1992 (1992-02-28), pages 1125 - 1127, XP002056591, ISSN: 0036-8075
GERRITSEN M E ET AL: "FLAVENOIDS INHIBIT CYTOKINE-INDUCED ENDOTHELIAL CELL ADHESION PROTEIN GENE EXPRESSION", AMERICAN JOURNAL OF PATHOLOGY,US,PHILADELPHIA, PA, vol. 147, no. 2, 1 August 1995 (1995-08-01), pages 278 - 292, XP000575649, ISSN: 0002-9440
ELICES M J ET AL: "VCAM-1 ON ACTIVATED ENDOTHELIUM INTERACTS WITH THE LEUKOCYTE INTEGRIN VLA-4 AT A SITE DISTINCT FROM THE VLA-4/FIBRONECTIN BINDING SITE", CELL,US,CELL PRESS, CAMBRIDGE, NA, vol. 60, 23 February 1990 (1990-02-23), pages 577 - 584, XP000606922, ISSN: 0092-8674
ROBINSON L A ET AL: "The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation.", JOURNAL OF IMMUNOLOGY, (1998 DEC 15) 161 (12) 6931-8., XP000887398
HAMMER C ET AL: "Organs from animals for man.", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY MAY, 1998, vol. 116, no. 1, May 1998 (1998-05-01), pages 5 - 21, XP000909785, ISSN: 1018-2438
ISOBE M ET AL: "SPECIFIC ACCEPTANCE OF CARDIAC ALLOGRAFT AFTER TREATMENT WITH ANTIBODIES TO ICAM-1 AND LFA1", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 255, 28 February 1992 (1992-02-28), pages 1125 - 1127, XP002056591, ISSN: 0036-8075
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