Title:
SURFACE GRAFTED CROSS-LINKED ZWITTERIONIC POLYMER COATING, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/216874
Kind Code:
A1
Abstract:
Disclosed in the present invention are a surface grafted cross-linked zwitterionic polymer coating, a preparation method therefor, and the use thereof. The present invention particularly relates to surface modification of medical instruments, such as biomedical materials and pipelines, for example, surface modification of medical instruments such as extracorporeal blood circulation pipelines and surfaces, artificial blood vessels, urinary catheters and endoscopes, so as to provide good anticoagulant and anti-biological adhesion functions. By simulating the structure of a tunica intima, the zwitterionic polymer coating having a simple process and excellent properties is constructed in the present invention, and said coating has a tunica intima-like surface micro-nano structure, an extremely low friction coefficient, soft elasticity and super-hydrophilicity, achieves zero activation and zero adhesion of platelets and thus provides a blood circulation effect of "no interference with blood", thus helping to avoid the problems of multiple complications and the like caused by thrombi of in-vivo artificial blood vessels and clinical extracorporeal blood circulation, and exhibiting great clinical application value.
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Inventors:
LI SHUANGYANG (CN)
DONG ANJIE (CN)
ZHANG JIANHUA (CN)
ZHANG YIQUN (CN)
LIU LINGYUAN (CN)
DONG ANJIE (CN)
ZHANG JIANHUA (CN)
ZHANG YIQUN (CN)
LIU LINGYUAN (CN)
Application Number:
PCT/CN2023/090614
Publication Date:
November 16, 2023
Filing Date:
April 25, 2023
Export Citation:
Assignee:
UNIV TIANJIN (CN)
International Classes:
C08F259/04; A61L27/34; A61L27/50; A61L31/10; C08F220/36; C08F220/38; C08F222/38; C08F283/00; C08F283/02
Foreign References:
| CN116003692A | 2023-04-25 | |||
| CN113521396A | 2021-10-22 | |||
| CN113713183A | 2021-11-30 | |||
| CN106421906A | 2017-02-22 | |||
| CN1887367A | 2007-01-03 | |||
| US20030165613A1 | 2003-09-04 |
Attorney, Agent or Firm:
MUDA INTELLECTUAL PROPERTY FIRM (CN)
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